OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11748335	Echoing findings from the Roadmap data, long LOCKs showed significant enrichment within common PMDs both in tumor and normal cell lines (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8916024	An analysis of the biomarker features between the sediment and the snail gut.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "analysis", "of", "the", "biomarker", "features", "between", "the", ...
PMC9429973	The mean hospital charges were $122,626 (SD $259,709).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "hospital", "charges", "were", "$", "122,626", "(", "SD", "$...
PMC11791264	The total number of cells in the images was determined by counting the stained nuclei.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "total", "number", "of", "cells", "in", "the", ...
PMC11653168	Stattic also induced a time-dependent upregulation of LC3B expression at 8, 16 and 24 h, suggesting enhanced autophagic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stattic", "also", ...
PMC9429973	Fifteen pts discontinued treatment before blina cons-1 due to refractory disease (n=8), toxicity (n=7) or death (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10047551	Induction with IFN-γ for a longer period could, in principle, be required for changes in DNA methylation to manifest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Induction", "with", ...
PMC10818573	We used B95-8 cellular DNA as the positive control, HeLa cell DNA as the negative control, and ddH2O as the blank control for amplification.	[ { "tags": [ "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11549062	The excessive expression of PTP1B effectively nullified the PDGF‐triggered tyrosyl phosphorylation of PDGFR‐β in insulin‐sensitive cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "excessive", "expression", "of", "PTP1B", "effec...
PMC7215832	Twenty-four hours (h) before the uptake experiment, the cells were treated with either RX-3117, DAC, or no drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-...
PMC9429973	Exploration of sabatolimab’s mechanism of action and identification of potential biomarkers predictive of response are planned.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exploration", "of", "sabatolimab", "’s", "mechani...
PMC7504302	For example, the loss of Merlin activity triggers cell proliferation through Hippo, PI3K/Akt/mTOR, and FAK pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "the", ...
PMC11344246	CDC20 gene expression was indeed higher in MCAS than JHOM1, with RMUG-S again having the lowest expression of the cell lines (Figure 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11706491	Despite its advantages, the use of bulky ATP analogs is not without drawbacks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "its", "advantages", ",", "the", "use", "of", "bulky",...
PMC5854676	The data shows the following dominant peaks in transmission mode.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "shows", "the", "following", "dominant", "peaks", "in", "transmission", "mode", ...
PMC11739484	Prognostic values of MMPs in skin cutaneous melanoma (SKCM) patients using GEPIA2 tool.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prognostic", "values", "of", "MMPs", "in", "skin", "cutaneo...
PMC9429973	Summary/Conclusion: Higher dose of CD34 cells promotes early recovery of NK cells after allo-HSCT with unmanipulated graft and NK30 represents a valuable prognostic marker of better outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	TPPP FL, EC50 = 0.54 μM, data was added as a point of comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TPPP", "FL", ",", "EC50", "=", "0.54", "μM", ...
PMC11767793	Petersen et al. listed three important characteristics of a positive control for in vitro assays—consistent performance, accessibility, and safety for the user and the environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the cytology of both cases, the population observed was more consistent with diffuse large B cell lymphoma (DLBCL) or possibly high-grade follicular lymphoma (FL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	Our data showed that when LPS-DOX was administered at a dose lower than 8 mg/kg, no abnormalities were observed in mouse behavior, no damage was shown in major organs, and there had been not a substantial variation within ALT, AST, CK, CK-MB, and LDH-L levels, therefore, 8 mg/kg was confirmed as the highest safe dose f...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	Nuclei were counterstained with DAPI (Invitrogen, USA), and the cells were examined using a confocal fluorescence microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", ...
PMC10840195	Determination of the migration ability of SR-A498 cells overexpressing Twist by cell scratch.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Determination", "of", "the", "migration", "ability", "of", "SR-A498", ...
PMC11568601	C TGT suppressed the invasion ability of osteosarcoma cells according to the transwell assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "TGT", "suppressed", "the", "invasion", "ability", "of", "os...
PMC11607638	The original calcium tracings presented were each from an individual cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "original", "calcium", "tracings", "presented", "were", "each", "from", "an", "...
PMC11705901	p < 0.05 Luciferase reporter gene assay showing the effect of different alleles of SNP rs1042778 in a SH-SY5Y (p = 0.006) and b H4 (p = 0.013). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	The pooled eluent was analyzed for step recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pooled", "eluent", "was", "analyzed", "for", "step", "recovery", "." ] } ]
PMC9621239	Differences in colony numbers among the Vector, WT, SM, DM and TM groups are presented on the right of the panel; Data are presented as mean ± SEM; Unpaired t test; n = 3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7917457	Purified CD8 T cells from cancer patients were presensitized with peptide-pulsed (10 μg/mL), irradiated, autologous PBMCs depleted of CD4 and CD8 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	After the incubation, the MTS reagent was added to the cells and incubated for 45 min at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "i...
PMC11381192	The intersection of two identified gene sets were further screened using the least absolute shrinkage and selection operator (LASSO) Cox regression algorithm in GSE24080.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6133382	After insertion of guide sequences, the vector contained all of the elements needed to induce a DSB in the MGAT1 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "ins...
PMC11122631	In the clinical drug development pipeline, the difficulties encountered by about 40–70% of molecules includes the poor aqueous solubility, absorption, and bioavailability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11767725	In addition to their direct effects on the microbiome, probiotics and postbiotics have systemic benefits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "their", "direct", "effects", ...
PMC10470467	To verify the accuracy of the analysis in this study, we performed RT-qPCR to compare the expression levels of 3 key genes between bone marrow stroma and ES cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	We first validated our fractionation by confirming robust chromatin enrichment of the two canonically chromatin-associated lncRNAs, NEAT1 and KCNQ1OT1 (Fig. S2A), and the cytoplasmic enrichment of the two mRNAs ACTB and GAPDH (Fig. S2B) under normal conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	The TORC1 complex is rapamycin‐sensitive, while the TORC2 complex is insensitive to rapamycin (Brunkard, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TORC1", "complex", "is", ...
PMC11377827	Functionally, USP43 depletion decreases the activation of HIF-1 target genes, without altering HIF-2 signalling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Functionally", ",", "USP43", "depletion", "decreases", ...
PMC9429973	Image: Summary/Conclusion: FMC63 quantification through dPCR was effective for CAR-T measurement, even improving MFC sensitivity, especially when CAR-T counting in PB is low in late monitoring days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	7 of these were < 18 years (age range 1-16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "7", "of", "these", "were", "<", "18", "years", "(", "age",...
PMC11297139	Immunocytochemistry data showed that the endogenous ARID1A formed condensate within WT and ARID1A + WT cells (LLPS positive), whereas ARID1A was diffusive in ARID1A + ΔDD cells (LLPS negative) (Fig. 3d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	The data are presented as the mean fluorescence intensity (MFI) ± standard deviation (SD) of gated events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "ar...
PMC9429973	Secondary objectives include the characterization of clinical management in both cohorts and, specifically for midostaurin cohort, the evaluation of the effectiveness according to IWG-MRT-ECNM criteria, the impact on the quality of life (QoL) and the safety of midostaurin in AdvSM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	Fig. 2Successful pharmacological targeting of ES using iP300w.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2Successful", "pharmacological", "targeting", "of", "ES", "using", "iP300w", "." ] } ]
PMC11575040	Either the lower side or the upper side of polycarbonate Transwell membranes (containing 8-μm pores) were coated with 50 μg/mL type I collagen or 80 μg/well Matrigel and used for migration or invasion assays, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	Additionally, it induced a notable expansion of human MDSC in in vitro models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "it", "induced", "a", "notable", "expansion", ...
PMC9429973	Among those who received subsequent therapy, the most common immediate next line of therapy included additional BCL2i-based therapy (venetoclax re-treatment with or without other agents, n=71/116; 61.2%) or anti-CD20 antibody-based therapy (with or without other agents, 73/116 (62.9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213199	Top 20 pathways in KEGG enrichment by Q-Value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top", "20", "pathways", "in", "KEGG", "enrichment", "by", "Q-Value", "." ] } ]
PMC9019892	It has been demonstrated that imatinib resistance in GISTs is caused by the feedback activation of FGF signalling, which results in a rebound in ERK phosphorylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	Despite recent advances in the diagnosis and treatment of HCC, it remains a highly lethal disease (2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "recent", "advance...
PMC9429973	Image: Summary/Conclusion: Seroconversion rates are lower in patients diagnosed with CLL or NHL, but normal for MM patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Sum...
PMC7189327	Herein, if AUC values of the genes were greater than 0.9, these genes were considered to discriminate patients undergoing BCC from healthy controls with high specificity and sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6643347	Under incomplete suppression of virus replication, favorable conditions for the selective selection of resistant forms are established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "incomplete", "suppression", "of", ...
PMC5600151	Finally, these branches are attached to a central core when they reach the desired generation size .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "these", "branches", "are", ...
PMC11483468	Telomerase is an excellent target for cancer therapy, and candidate drugs targeting telomerase have market prospects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Telomerase", "is", "an", "excellent", "target", ...
PMC8584666	The culture medium (0.5 mL/well) was added on top of the agar layer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "culture", "medium", "(", "0.5", "mL/well", ")", ...
PMC6024716	The genomic region flanking the CRISPR target site for the OAZ1 gene was polymerase chain reaction (PCR) amplified, using the Phusion High-Fidelity PCR Master Mix with HF Buffer (NEB, cat# MO531S, Ipswitch, MA, USA), and the following primers: forward primer—cagcagcagtgagagttcca; reverse primer—gcttttggagagcaatggag.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763111	After 48 h of coculturing with the specified cells, CAR-T cells were sorted using flow cytometry (FACS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "48", "h", "of...
PMC11772449	Studies have confirmed that pirfenidone can maintain the stability of the tumor microenvironment and increase the route of chemotherapy drugs into the tumor by reducing the levels of hyaluronic acid and collagen in ECM (Polydorou et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Additionally, a significant correlation was observed in the function of the downstream ACYP2 MAPK pathway according to KEGG data (Fig. S4G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10606998	It is possible that ROS generation can be significantly increased by using other materials for the organic shell of nanoparticles, which would be partially or completely destroyed under the action of irradiation, exposing the surface of the nanoparticles; for example, it may be citrate or malate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750161	The pcDNA3 mammalian expression vector, CHO-S cells, FreeStyle MAX reagent, and FreeStyle CHO expression medium were purchased from Invitrogen (Carlsbad, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	This effect was far stronger than when promoter DNA was selectively demethylated using dCas9 fused to a 5‐methylcytosine dioxygenase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "was", "far", ...
PMC11767725	Lifestyle interventions, including weight loss, smoking cessation, and dietary adjustments, play a significant role in managing HS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lifestyle", "interventi...
PMC9429973	Secondary endpoints include investigator-assessed event-free survival, OS, safety, and tafasitamab serum concentration (trough and Cmax levels).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "endpoints"...
PMC11791203	The identification of the active molecule/s in the chloroform extract will serve as drug candidate for colorectal carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "identification", "of", "the", "...
PMC11469524	These pathways are often activated by ligands that bind to cognate cell surface receptors and activate a specific set of intracellular proteins, often by tyrosine or serine/threonine phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	Data are presented as the mean ± SEM of three replicates. ***,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", ...
PMC11741906	Interestingly, High expression of hsa-miR-133b, hsa-miR-512-are, hsa-miR-200b-3p, and hsa-miR-451a is related to poor overall survival in patients diagnosed with ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9964654	A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) ovarian tumor cells were purchased from Sigma-Aldrich.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A2780", "(", "cisplatin-sensitive", ")", "...
PMC11610461	Through continuous exploration by researchers, PSENEN has been confirmed as a direct target for metformin and acts as an anti-glycemic agent by activating the AMPK pathway (Ma et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10048572	However, lesions found in the onset of the disease are often belonged to a predominant tumor clone, and further observation makes it possible to assess the fate of this clone during therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476106	Specifically, cluster density of the A673 cell line (Figure 4A) was higher when cultured in HGs without added VN than with added VN (median = 0.0302 cluster/nm vs median = 0.0263 cluster/nm, respectively) at both short and long culture times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411004	We compared the effects of three inhibitors—SAHA (1.42-fold), sodium butyrate (1.47-fold), and valproic acid (1.82-fold)—with that of I-4 (2.36-fold) and found that I-4 had a great advantage in enhancing the production of ADM recombinant proteins (Fig. 2a, b).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10671321	After several washings, they were incubated in blocking buffer (Abcam, Cambridge, USA) for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC11429241	To optimize the pore size and the structure of the scaffolds themselves, we need to consider the physical parameters of the cells to create the best possible environment for cell growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	We thus further investigated the effect of PKF-118-310 on parental PDAC cells and MRTX1133-resistant PDAC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "We", "thus", "further", "investigat...
PMC11792766	The concentration is expressed in % v/v total organic content (individual solvent concentration is half of the total organic content).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "conce...
PMC6892818	Equal loading for human epithelial cell lysate was confirmed by CK18 detection (see Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "loading", "for", "human", "epithelial", "cell...
PMC8097906	RMS can be histologically classified in several subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RMS", "can", "be", "histologically", "classified", "in", "several", "subtypes", "." ] } ]
PMC10858941	β-actin was used as a loading control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-actin", "was", "used", "as", "a", "loading", "control", "." ] } ]
PMC11401350	It was also believed that in PTCL PD-1 itself could be a tumor suppressor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "also", "believed", "that", "in", "PTCL", "PD-1", ...
PMC8996378	Lathyranes and jatrophanes are macrocyclic diterpenes characteristic of Euphorbia genus (Euphorbiaceae family), from which many compounds showed significant MDR reversing activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11790599	We analyzed the gene expression profile obtained from the Cancer Cell Line Encyclopedia (CCLE) database and confirmed that epidermal growth factor receptor 1 (HER1 or EGFR), which contributes to the development and progression of breast cancer similar to HER2 (Nuciforo et al., 2015; Witton et al., 2003), is highly expr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11678368	The structural formulas of these complexes are given in Figure 1g and h, respectively (they provide a clear illustration of the location of single and double bonds within the ligands).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11713609	These data indicate that PHLDA2 is critical for p53-mediated tumor suppression through ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "indicate", "that", "PHLDA2", "is", "critical", "for", ...
PMC3888431	The Isotig object represents a specific splice variant and, in contrast to the original GenDB-backend, the sequence information is derived by the concatenation of NGSContig objects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	b.), (c.), and (d.) Represents glutamate (GLU) in retention time of 8.15 min, 7.89 min, and 8.14 min for control, PMA, and PG72 groups, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	Quantification of C. albicans colonisation from D. N = 28 control and 29 isotonic treated larvae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "C.", "albicans", "colonisation", ...
PMC6892818	Results are presented as Cell death fold increase in background-corrected RLU readings relative to control and are representative of two independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "a...
PMC6102174	As a result, three new compounds, 4-pyridoneglucoside (18), 3S,8S-dihydroxydec-9-en-4,6-yne 1-O-(6′-O-caffeoyl)-β-d-glucopyranoside (19) and 3S,8S-dihydroxydec-9-en-4,6-yne 1-O-(2′-O-caffeoyl)-β-d-glucopyranoside (20) were obtained from the active part under the guidance of LCMS analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9583612	Advances in technologies such as continuous emission monitoring systems (CEMS) could provide the high-resolution data needed to characterize temporal variability in methane emissions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11655536	TFE3 is phosphorylated by mTOR and locates in the cytoplasm .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TFE3", "is", "phosphorylated", "by", "mTOR", "and", "locates", "in", "the", "cytoplasm", "...
PMC8973085	Hence, the IR spectra showed bands owing to the CN group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "IR", "spectra", "showed", "bands", "owing", "to", "th...
PMC11792888	After incubation at 37°C, 5% CO2 overnight, cells were treated with the corresponding ½IC50, IC50, and 2xIC50 doses for 48 h. The 48-h incubation period was chosen to minimize the confounding effects of primary cell death, especially at the highest venom doses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774747	They successfully enriched IFN-γ+ T cells from pre-enrichment levels of 0.8 ± 0.5% to post-selection levels of 76.3% ± 11.6% (92, 93).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	However, due to its non-human nature, it can produce non-human PTMs such as galactose-α1,3-galactose and N-glycolylneuraminic acid .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "due", "to", ...
PMC9429973	pneumoniae was detected in 35 cases (50%), and resistance to carbapenems was reported in 68.6% of strains of the Kl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Aims: To explore the safety and efficacy of VEN-AZA or VEN-LDAC regimens in combination with Quizartinib (QUI) (VEN-A-QUI trial; EUDRACT2020-000406-28).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	When the cells were preincubated with catalase, the fluorescence intensity of the probe did not increase (Figure 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "ce...

PMC11748335

Echoing findings from the Roadmap data, long LOCKs showed significant enrichment within common PMDs both in tumor and normal cell lines (Fig. 3A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC8916024

An analysis of the biomarker features between the sediment and the snail gut.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "analysis", "of", "the", "biomarker", "features", "between", "the", ...

PMC9429973

The mean hospital charges were $122,626 (SD $259,709).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "hospital", "charges", "were", "$", "122,626", "(", "SD", "$...

PMC11791264

The total number of cells in the images was determined by counting the stained nuclei.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "total", "number", "of", "cells", "in", "the", ...

PMC11653168

Stattic also induced a time-dependent upregulation of LC3B expression at 8, 16 and 24 h, suggesting enhanced autophagic activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stattic", "also", ...

PMC9429973

Fifteen pts discontinued treatment before blina cons-1 due to refractory disease (n=8), toxicity (n=7) or death (n=2).

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PMC10047551

Induction with IFN-γ for a longer period could, in principle, be required for changes in DNA methylation to manifest.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Induction", "with", ...

PMC10818573

We used B95-8 cellular DNA as the positive control, HeLa cell DNA as the negative control, and ddH2O as the blank control for amplification.

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PMC11549062

The excessive expression of PTP1B effectively nullified the PDGF‐triggered tyrosyl phosphorylation of PDGFR‐β in insulin‐sensitive cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "excessive", "expression", "of", "PTP1B", "effec...

PMC7215832

Twenty-four hours (h) before the uptake experiment, the cells were treated with either RX-3117, DAC, or no drug.

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PMC9429973

Exploration of sabatolimab’s mechanism of action and identification of potential biomarkers predictive of response are planned.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exploration", "of", "sabatolimab", "’s", "mechani...

PMC7504302

For example, the loss of Merlin activity triggers cell proliferation through Hippo, PI3K/Akt/mTOR, and FAK pathways.

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PMC11344246

CDC20 gene expression was indeed higher in MCAS than JHOM1, with RMUG-S again having the lowest expression of the cell lines (Figure 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11706491

Despite its advantages, the use of bulky ATP analogs is not without drawbacks.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "its", "advantages", ",", "the", "use", "of", "bulky",...

PMC5854676

The data shows the following dominant peaks in transmission mode.

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PMC11739484

Prognostic values of MMPs in skin cutaneous melanoma (SKCM) patients using GEPIA2 tool.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prognostic", "values", "of", "MMPs", "in", "skin", "cutaneo...

PMC9429973

Summary/Conclusion: Higher dose of CD34 cells promotes early recovery of NK cells after allo-HSCT with unmanipulated graft and NK30 represents a valuable prognostic marker of better outcomes.

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PMC11342785

TPPP FL, EC50 = 0.54 μM, data was added as a point of comparison.

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PMC11767793

Petersen et al. listed three important characteristics of a positive control for in vitro assays—consistent performance, accessibility, and safety for the user and the environment.

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PMC9429973

In the cytology of both cases, the population observed was more consistent with diffuse large B cell lymphoma (DLBCL) or possibly high-grade follicular lymphoma (FL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11144200

Our data showed that when LPS-DOX was administered at a dose lower than 8 mg/kg, no abnormalities were observed in mouse behavior, no damage was shown in major organs, and there had been not a substantial variation within ALT, AST, CK, CK-MB, and LDH-L levels, therefore, 8 mg/kg was confirmed as the highest safe dose f...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11763126

Nuclei were counterstained with DAPI (Invitrogen, USA), and the cells were examined using a confocal fluorescence microscope.

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PMC10840195

Determination of the migration ability of SR-A498 cells overexpressing Twist by cell scratch.

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PMC11568601

C TGT suppressed the invasion ability of osteosarcoma cells according to the transwell assay.

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PMC11607638

The original calcium tracings presented were each from an individual cell.

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PMC11705901

p < 0.05 Luciferase reporter gene assay showing the effect of different alleles of SNP rs1042778 in a SH-SY5Y (p = 0.006) and b H4 (p = 0.013). *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...

PMC9532503

The pooled eluent was analyzed for step recovery.

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PMC9621239

Differences in colony numbers among the Vector, WT, SM, DM and TM groups are presented on the right of the panel; Data are presented as mean ± SEM; Unpaired t test; n = 3. (

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PMC7917457

Purified CD8 T cells from cancer patients were presensitized with peptide-pulsed (10 μg/mL), irradiated, autologous PBMCs depleted of CD4 and CD8 T cells.

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PMC11683240

After the incubation, the MTS reagent was added to the cells and incubated for 45 min at 37 °C.

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PMC11381192

The intersection of two identified gene sets were further screened using the least absolute shrinkage and selection operator (LASSO) Cox regression algorithm in GSE24080.

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PMC6133382

After insertion of guide sequences, the vector contained all of the elements needed to induce a DSB in the MGAT1 gene.

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PMC11122631

In the clinical drug development pipeline, the difficulties encountered by about 40–70% of molecules includes the poor aqueous solubility, absorption, and bioavailability .

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PMC11767725

In addition to their direct effects on the microbiome, probiotics and postbiotics have systemic benefits.

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PMC10470467

To verify the accuracy of the analysis in this study, we performed RT-qPCR to compare the expression levels of 3 key genes between bone marrow stroma and ES cells.

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PMC8873393

We first validated our fractionation by confirming robust chromatin enrichment of the two canonically chromatin-associated lncRNAs, NEAT1 and KCNQ1OT1 (Fig. S2A), and the cytoplasmic enrichment of the two mRNAs ACTB and GAPDH (Fig. S2B) under normal conditions.

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PMC11541241

The TORC1 complex is rapamycin‐sensitive, while the TORC2 complex is insensitive to rapamycin (Brunkard, 2020).

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PMC11377827

Functionally, USP43 depletion decreases the activation of HIF-1 target genes, without altering HIF-2 signalling.

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PMC9429973

Image: Summary/Conclusion: FMC63 quantification through dPCR was effective for CAR-T measurement, even improving MFC sensitivity, especially when CAR-T counting in PB is low in late monitoring days.

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PMC9429973

7 of these were < 18 years (age range 1-16).

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PMC11297139

Immunocytochemistry data showed that the endogenous ARID1A formed condensate within WT and ARID1A + WT cells (LLPS positive), whereas ARID1A was diffusive in ARID1A + ΔDD cells (LLPS negative) (Fig. 3d).

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PMC11092418

The data are presented as the mean fluorescence intensity (MFI) ± standard deviation (SD) of gated events.

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PMC9429973

Secondary objectives include the characterization of clinical management in both cohorts and, specifically for midostaurin cohort, the evaluation of the effectiveness according to IWG-MRT-ECNM criteria, the impact on the quality of life (QoL) and the safety of midostaurin in AdvSM.

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PMC11453018

Fig. 2Successful pharmacological targeting of ES using iP300w.

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PMC11575040

Either the lower side or the upper side of polycarbonate Transwell membranes (containing 8-μm pores) were coated with 50 μg/mL type I collagen or 80 μg/well Matrigel and used for migration or invasion assays, respectively.

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PMC11656657

Additionally, it induced a notable expansion of human MDSC in in vitro models.

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PMC9429973

Among those who received subsequent therapy, the most common immediate next line of therapy included additional BCL2i-based therapy (venetoclax re-treatment with or without other agents, n=71/116; 61.2%) or anti-CD20 antibody-based therapy (with or without other agents, 73/116 (62.9%).

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PMC10213199

Top 20 pathways in KEGG enrichment by Q-Value.

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PMC9019892

It has been demonstrated that imatinib resistance in GISTs is caused by the feedback activation of FGF signalling, which results in a rebound in ERK phosphorylation .

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PMC8270637

Despite recent advances in the diagnosis and treatment of HCC, it remains a highly lethal disease (2).

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PMC9429973

Image: Summary/Conclusion: Seroconversion rates are lower in patients diagnosed with CLL or NHL, but normal for MM patients.

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PMC7189327

Herein, if AUC values of the genes were greater than 0.9, these genes were considered to discriminate patients undergoing BCC from healthy controls with high specificity and sensitivity.

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PMC6643347

Under incomplete suppression of virus replication, favorable conditions for the selective selection of resistant forms are established.

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PMC5600151

Finally, these branches are attached to a central core when they reach the desired generation size .

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PMC11483468

Telomerase is an excellent target for cancer therapy, and candidate drugs targeting telomerase have market prospects.

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PMC8584666

The culture medium (0.5 mL/well) was added on top of the agar layer.

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PMC6024716

The genomic region flanking the CRISPR target site for the OAZ1 gene was polymerase chain reaction (PCR) amplified, using the Phusion High-Fidelity PCR Master Mix with HF Buffer (NEB, cat# MO531S, Ipswitch, MA, USA), and the following primers: forward primer—cagcagcagtgagagttcca; reverse primer—gcttttggagagcaatggag.

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PMC11763111

After 48 h of coculturing with the specified cells, CAR-T cells were sorted using flow cytometry (FACS).

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PMC11772449

Studies have confirmed that pirfenidone can maintain the stability of the tumor microenvironment and increase the route of chemotherapy drugs into the tumor by reducing the levels of hyaluronic acid and collagen in ECM (Polydorou et al., 2017).

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PMC11391695

Additionally, a significant correlation was observed in the function of the downstream ACYP2 MAPK pathway according to KEGG data (Fig. S4G).

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PMC10606998

It is possible that ROS generation can be significantly increased by using other materials for the organic shell of nanoparticles, which would be partially or completely destroyed under the action of irradiation, exposing the surface of the nanoparticles; for example, it may be citrate or malate .

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PMC11750161

The pcDNA3 mammalian expression vector, CHO-S cells, FreeStyle MAX reagent, and FreeStyle CHO expression medium were purchased from Invitrogen (Carlsbad, CA, USA).

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PMC11629143

This effect was far stronger than when promoter DNA was selectively demethylated using dCas9 fused to a 5‐methylcytosine dioxygenase.

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PMC11767725

Lifestyle interventions, including weight loss, smoking cessation, and dietary adjustments, play a significant role in managing HS.

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PMC9429973

Secondary endpoints include investigator-assessed event-free survival, OS, safety, and tafasitamab serum concentration (trough and Cmax levels).

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PMC11791203

The identification of the active molecule/s in the chloroform extract will serve as drug candidate for colorectal carcinoma.

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PMC11469524

These pathways are often activated by ligands that bind to cognate cell surface receptors and activate a specific set of intracellular proteins, often by tyrosine or serine/threonine phosphorylation.

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PMC11300639

Data are presented as the mean ± SEM of three replicates. ***,

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PMC11741906

Interestingly, High expression of hsa-miR-133b, hsa-miR-512-are, hsa-miR-200b-3p, and hsa-miR-451a is related to poor overall survival in patients diagnosed with ovarian cancer.

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PMC9964654

A2780 (cisplatin-sensitive) and A2780cisR (cisplatin-resistant) ovarian tumor cells were purchased from Sigma-Aldrich.

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PMC11610461

Through continuous exploration by researchers, PSENEN has been confirmed as a direct target for metformin and acts as an anti-glycemic agent by activating the AMPK pathway (Ma et al., 2022).

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PMC10048572

However, lesions found in the onset of the disease are often belonged to a predominant tumor clone, and further observation makes it possible to assess the fate of this clone during therapy.

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PMC11476106

Specifically, cluster density of the A673 cell line (Figure 4A) was higher when cultured in HGs without added VN than with added VN (median = 0.0302 cluster/nm vs median = 0.0263 cluster/nm, respectively) at both short and long culture times.

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PMC11411004

We compared the effects of three inhibitors—SAHA (1.42-fold), sodium butyrate (1.47-fold), and valproic acid (1.82-fold)—with that of I-4 (2.36-fold) and found that I-4 had a great advantage in enhancing the production of ADM recombinant proteins (Fig. 2a, b).Fig.

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PMC10671321

After several washings, they were incubated in blocking buffer (Abcam, Cambridge, USA) for 1 h at room temperature.

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PMC11429241

To optimize the pore size and the structure of the scaffolds themselves, we need to consider the physical parameters of the cells to create the best possible environment for cell growth.

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PMC11536589

We thus further investigated the effect of PKF-118-310 on parental PDAC cells and MRTX1133-resistant PDAC cells.

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PMC11792766

The concentration is expressed in % v/v total organic content (individual solvent concentration is half of the total organic content).

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PMC6892818

Equal loading for human epithelial cell lysate was confirmed by CK18 detection (see Methods).

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PMC8097906

RMS can be histologically classified in several subtypes.

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PMC10858941

β-actin was used as a loading control.

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PMC11401350

It was also believed that in PTCL PD-1 itself could be a tumor suppressor .

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PMC8996378

Lathyranes and jatrophanes are macrocyclic diterpenes characteristic of Euphorbia genus (Euphorbiaceae family), from which many compounds showed significant MDR reversing activity.

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PMC11790599

We analyzed the gene expression profile obtained from the Cancer Cell Line Encyclopedia (CCLE) database and confirmed that epidermal growth factor receptor 1 (HER1 or EGFR), which contributes to the development and progression of breast cancer similar to HER2 (Nuciforo et al., 2015; Witton et al., 2003), is highly expr...

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PMC11678368

The structural formulas of these complexes are given in Figure 1g and h, respectively (they provide a clear illustration of the location of single and double bonds within the ligands).

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PMC11713609

These data indicate that PHLDA2 is critical for p53-mediated tumor suppression through ferroptosis.

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PMC3888431

The Isotig object represents a specific splice variant and, in contrast to the original GenDB-backend, the sequence information is derived by the concatenation of NGSContig objects.

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PMC10809689

b.), (c.), and (d.) Represents glutamate (GLU) in retention time of 8.15 min, 7.89 min, and 8.14 min for control, PMA, and PG72 groups, respectively.

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PMC11628904

Quantification of C. albicans colonisation from D. N = 28 control and 29 isotonic treated larvae.

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PMC6892818

Results are presented as Cell death fold increase in background-corrected RLU readings relative to control and are representative of two independent experiments.

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PMC6102174

As a result, three new compounds, 4-pyridoneglucoside (18), 3S,8S-dihydroxydec-9-en-4,6-yne 1-O-(6′-O-caffeoyl)-β-d-glucopyranoside (19) and 3S,8S-dihydroxydec-9-en-4,6-yne 1-O-(2′-O-caffeoyl)-β-d-glucopyranoside (20) were obtained from the active part under the guidance of LCMS analyses.

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PMC9583612

Advances in technologies such as continuous emission monitoring systems (CEMS) could provide the high-resolution data needed to characterize temporal variability in methane emissions.

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PMC11655536

TFE3 is phosphorylated by mTOR and locates in the cytoplasm .

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PMC8973085

Hence, the IR spectra showed bands owing to the CN group.

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PMC11792888

After incubation at 37°C, 5% CO2 overnight, cells were treated with the corresponding ½IC50, IC50, and 2xIC50 doses for 48 h. The 48-h incubation period was chosen to minimize the confounding effects of primary cell death, especially at the highest venom doses.

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PMC11774747

They successfully enriched IFN-γ+ T cells from pre-enrichment levels of 0.8 ± 0.5% to post-selection levels of 76.3% ± 11.6% (92, 93).

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PMC10237474

However, due to its non-human nature, it can produce non-human PTMs such as galactose-α1,3-galactose and N-glycolylneuraminic acid .

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PMC9429973

pneumoniae was detected in 35 cases (50%), and resistance to carbapenems was reported in 68.6% of strains of the Kl.

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PMC9429973

Aims: To explore the safety and efficacy of VEN-AZA or VEN-LDAC regimens in combination with Quizartinib (QUI) (VEN-A-QUI trial; EUDRACT2020-000406-28).

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PMC11726848

When the cells were preincubated with catalase, the fluorescence intensity of the probe did not increase (Figure 6B).

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