OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11687663	Along with other phytoconstituents (B1-B7 and B11), Schaftoside (B7) violate the Lipinski’s rule of five whereas, Quercetin (B12) obey the rule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	In conclusion, our study shows that IL-27 upregulates MEG3 expression by inhibiting DNMT1-mediated lncRNA MEG3 promoter methylation, which in turn inhibits the ERK/p38 signaling pathway to induce autophagy to attenuate BLM-induced PF, that provides help to elucidate the potential mechanism by which IL-27 attenuates PF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	In normal circumstances, GSH accounts for 90–95% of the tGSH, with less than 70% resulting in significant oxidative stress-related damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6133382	To be a viable substrate for biopharmaceutical production, the growth and protein yield of the knockout line had to be comparable to the parental line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11252553	However, radiotherapy can negatively impact neighboring healthy tissues, leading to the necessitation of dose limitation to minimize harm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "radiotherapy...
PMC9436459	Seven type I MDAAs might be variations of some classic MDAAs, in which the phenyl moieties at C-8" or the benzoyl moieties at C-4" is missing, as exemplified by compounds 160 − 161 or 162 − 166 [123, 138–140], respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	The cells were cultured in the presence of the phage overnight and the next day the phage concentration was measured using the activity-independent plaque assay, similar to above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453346	M. Tsachaki: None.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "M.", "Tsachaki", ":", "None", "." ] } ]
PMC6627640	However, the relationship between TGCT epigenetics and curability and chemoresistance is largely uncharacterized and has been limited to a few studies related to gene specific DNA methylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	By constructing in vivo and in vitro models with RBM39 interference, we found that RBM39 is crucial for the proliferation and survival of T-ALL tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489275	Based on the first to 14th day after admission, the two adjacent days were combined into one group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "the", "first", ...
PMC7305184	30 generations of CTRL and EP group are shown at different electric fields.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "30", "generations", "of", "CTRL", "and", "EP", "group", "are", "shown...
PMC11700247	Moreover, the group that received T cells from the combination-treated donors showed increased infiltration by CD8 T cells (Figure 4D) and cytotoxic T cells within the tumor (Figure 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700340	Multiple studies indicate that the cytoprotection conferred by HSP is partially mediated by suppressing spontaneous and therapy-induced apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "studies", "indicate", "that", ...
PMC11803918	This discovery led us to formulate a more potent immunotherapy approach using γδ-T exosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "discovery", "led", "us", "to", "formulate", "a", "more",...
PMC11337594	This lays the foundation for TER as a potential anti-melanoma drug in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "lays", "the", "foundation", "for", "TER", "as", "a", ...
PMC10887351	I, Gα.q, and Gα.12) to which the receptor is coupled .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", ",", "Gα.q", ",", "and", "Gα.12", ")", "to", "which", "the"...
PMC6379402	These networks, represented by their adjacency matrices, Ai, are simultaneously decomposed as the product of three factors, G, Si, and G, as detailed in Methods (illustrated in the middle panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	Blow the cells repeatedly with a pipette and then move to a 1.5 ml Eppendorf tube.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blow", "the", "cells", "repeatedly", "with", "a", ...
PMC9429973	Median RFS was 27.8m, 15.4m, 7.3m, and 5.2m in the IA MRD(-), Lo + VEN MRD(-), IA MRD(+), and Lo + VEN MRD(+) groups, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11658074	These results suggest that AT has a protective effect on the skin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "AT", "has", "a", "protective", "effect", ...
PMC11772585	Mix the contents thoroughly, then incubate in a water bath at 37 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mix", "the", "contents", "thoroughly", ...
PMC11725127	A peptide with a calculated mass of 1321.70 Da, which is 628 Da larger than the Cys284-containing peptide NSILQCLSN with a calculated mass of 693.70 Da was identified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	PTK2B was also post-translationally stabilized in TKI resistant cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTK2B", "was", "also", "post-translationally", "stabilized", "in", "TKI", "resistant", "cells", "." ] ...
PMC11772585	Increased expression of HK2 has been identified in several cancer types, such as melanoma , glioma , and bladder cancer , impacting both glycolysis and mitochondrial function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9856122	Protoberberine alkaloids show prominent effects against HSV, HBV, SARS-CoV, SARS-CoV-2, and HCMV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protoberberine", "alkaloids", "show", "prominent", "effects"...
PMC7039683	gkmSVM were performed to generate a scoring vector (parameter: K = 6, L = 10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "gkmSVM", "were", "performed", "to...
PMC10849234	18 hours later, transduced cells were centrifuged (100G; 10 minutes) and resuspended in selection media (supplemented RPMI-1640).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11406030	This work was partially funded by a grant from Temple Therapeutics (MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "was", "partially", "funded", "by", ...
PMC9429973	The sudden rise of transaminases and bilirubin levels was registered in 3 patients and led to treatment discontinuation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sudden", "rise", "of", "transam...
PMC10547921	PNU-159682 caused S-phase cell cycle arrest due to its DNA-damaging activity, while MMAF simultaneously inhibited tubulin polymerization and caused G2/M-phase cell cycle arrest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11507371	Mean intensities of proteins associated with Nrf2 and NF-κB signalling in A431 and HaCaT cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Mean", "intensities", "of", "proteins", "a...
PMC8662250	For these experiments, undifferentiated Caco‐2 cells were cultured onto coverslips until confluence and divided into four groups: 1) Vehicle, 2) 10 ng/ml SP, 3) 10 ng/ml SP plus 10 M CBD, and 4) 10 ng/ml SP with 10 M CBD plus 9 nM GW9662 antagonist PPAR‐γ.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	Overlap with certain connective tissue diseases is possible, as antinuclear antibodies have been detected in some cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overlap", "with", "certain", "connective", ...
PMC11496491	GO enrichment analysis results show the top 10 Term analysis charts that are most significant in terms of cell components. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "enrichment", ...
PMC11761919	Additionally, significantly increased mRNA levels of IL-2, IFN-γ were observed in the spleen tissues of chickens immunized with Micro-E/Fiber2-PINs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", ...
PMC11730311	Interestingly, the lower abundance of C-terminal fragments identified from hαCGRP8-37S19K-C20DA-γGlu compared to hαCGRP8-37N25K-C20DA-γGlu suggest that positioning the C20DA-γGlu conjugation within the LLSR motif offer greater protection against in vivo cleavage in this region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	VTE did not show any cytotoxicity and inhibited the migration of SW982 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "VTE", "did", "not", "show", "any", "cytotoxicity", "and", "inhibit...
PMC10957991	Bar 140 um. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "140", "um", ".", "(" ] } ]
PMC9429973	Crude numbers of HRU were determined by the number of inpatient admissions and outpatient visits in the first year after diagnosis or cohort entry and for the entire follow-up period for each season.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553	The absence of the deposition of complement C3 or C5b-9 complex in intracranial aneurysm lesions. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absence", "of", "the", "deposition", "of", ...
PMC9429973	The Top 10 list is predominantly about improving pharmacological treatments for multiple myeloma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Top", "10", "list", "is", "predominantly", "about", "improving", ...
PMC11342785	These outposts are thought to act as hubs that concentrate TPPP with interaction partners, including the condensate-forming Golgi matrix protein GM130 (29, 46, 47).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: These data represent complete analysis of all patients in the induction phase of MAGNIFY which continue to support that R is active with a tolerable safety profile in patients with R/R FL grade 1–3a and MZL, including rituximab-refractory, double-refractory, and early relapse patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	The WISC-IV, which is appropriate for children ages 6 years to 16 years and 11 months, encompasses a range of tests including Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed (which included subtests for symbol search and cancellation), along with providing a combined full-scale IQ score ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In 73% and 40% of pts in co2, POM dose was increased to 1 mg and 2 mg QD after cycle 3 and 6, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676674	MMC has been demonstrated to possess genotoxic effects in both in vitro (mammalian cells) and in vivo (animals) studies, and it has been clearly proven to be a carcinogenic substance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731161	Slides were incubated with primary antibody against USP7 (1:100, Santa Cruz) or Ki67 (1:200, Proteintech) overnight at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11786156	CD54 is involved in cell-to-cell adhesion and proliferation of cultured cells, such as Raji cells (a human Burkitt lymphoma cell line) and A20 cells (a mouse B-cell lymphoma cell line) by activating ERK and Lyn.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", ...
PMC11629143	For selection, media was supplemented 48‐h post‐transfection with 250 µg/mL Zeocin (for dCas9), 400 µg/mL G418 (for dCas9‐p300) or 100 µg/mL Hygromycin (for dCas9‐HDAC1) every 2–3 days for 2 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	The percentage of synapses incorporating active terminals in these experiments was ~10% (control/NL2), 24% (α4β3δ-GABAAR/NL2), and 30% (α2β2γ2-GABAAR/NL2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This is a retrospective, descriptive study based on patients data diagnosed with COVID- 19 in Quito-Ecuador in Hospital Metropolitano who required general hospitalization and/or intensive care unit; each of them received convalescent plasma from patients with previous infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	c Overlap of splicing events (exon skipping and intron retention) with up- or downregulated proteins after 16 h of indisulam treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", ...
PMC9688728	However, the role of this metabolite is not fully understood, and there is evidence that cadaverine has a positive effect on the treatment of breast cancer through reduced metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	On the basis of these findings, we hypothesized that STXBP5 and progerin may interact.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "basis", "of", "these", "findings", ",", ...
PMC6600592	Pale yellow liquid, yield 70.8%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pale", "yellow", "liquid", ",", "yield", "70.8", "%", "." ] } ]
PMC9429973	EVcargo is an indirect and more affordable measure to infer EV protein load compared to mass-spectrometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EVcargo", "is", "an", "indirect", "and", "more", ...
PMC11750696	In recent studies, the UPR and ER stress are recognized as pivotal regulators that shape the maturation and functional dynamics of T helper lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7294030	These pathways are important in tumor progression and metastasis (Reddy et al., 2003).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "pathways", "are", "important", "in", "tumor",...
PMC11711347	The interaction of Oxygen with the Ni metal ions is indicated by its absorption peak at 387 cm (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inter...
PMC9164404	This work highlighted the use of multi-omics for the mechanism study of Abplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "highlighted", "the", "use", "of", "multi-omics", "for", ...
PMC11755467	Unlike nalidixic acid, Enoxacin contains 6-fluoro- and 7-piperazin-1-yl substituents that are capable of forming additional interactions with target molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unlike", "nalidixic", "acid"...
PMC10507284	Therefore, we analyzed the correlation between TROAP and preclinical and clinical drugs to discover potential treatments for STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "analyzed"...
PMC9429973	NOTCH3 and RELN mutations were only 3/20 (10%) in those who did not reach 12M-MMR group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NOTCH3", "and", "RELN", "mutation...
PMC9917080	In our experiments, all studied agents led to an increase in SELENON expression, but the SeSo nanocomplex turned out to be especially effective, which in the case of astrocytes can be regarded as a positive effect aimed at enhancing their viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	They are a fast-growing cell line, composed mostly of small spindle-shaped cells, with few larger multinucleated cells, likely due to events of aberrant mitosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	Traditional cancer treatment primarily relies on surgery, radiotherapy and/or chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Traditional", "cancer", "treatment", "primarily", "relies", "on", "surgery", ",", "radiothe...
PMC11676670	This subtype has been characterized by the following characteristics: frequent mutations in key genes, such as TP53, NF1, BRCA1, BRCA2, RB1, CDK12, FAT3, and CSMD3, coupled with chromosomal copy number variations and genomic duplications .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	While the cyclopropyl group of Filgotinib pointed towards an open space (solvent-exposed region) that could possibly accommodate a relatively large motif.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While",...
PMC11040965	P < .05, **P ≤ .01, Wilcoxon signed-rank test We previously found that low levels of proteasome subunits reduced the recognition of MM plasma cells by tumor plasma cell-specific cytotoxic CD8 T lymphocytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502327	Astragalus polysaccharide (APS), a natural antitumor agent isolated from Astragalus membranaceus, has been shown to target the tumor suppressor F-box and WD-40 domain protein 7 through the regulation of miRNA, mediating miR-27a/FBXW 7 axis, which plays an anti-OC cell growth role in vitro (44).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9577200	The effect of different concentrations of CS on the viability of the HeLa cell line was assessed by CCK-8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "d...
PMC8345486	Doxorubicin HCl (99%; DOX042) was purchased from BioSchop Canada Inc. (Burlington, ON, Canada).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Doxorubicin", "HCl", ...
PMC10154881	In 2015, a herpes simplex virus‐based oncolytic virus received its first approval for melanoma treatment in the USA and Europe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2015", ",",...
PMC11721295	To better understand KRAS-dependent changes occurring in the tumor and tumor microenvironment, we utilized scRNA-seq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "better", "understand", "KRAS-dependent", "changes", ...
PMC11683240	The transport of PTS1 into the host cell cytosol relies on the assistance of host cell chaperones and enzymes that aid in the folding of proteins (25, 26, 27, 28).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994	Based on our results, we strongly recommend not to use only the usual statement “in vitro cytotoxicity was performed according to ISO 10,993 standard”, but to thoroughly describe all the aforementioned conditions used during the cytotoxicity testing including catalogue numbers of media.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627060	The average size of the synthesized BSA NPs is less than 200 nm, while TQ–BSA NPs had an average size of 187 ± 8 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6133382	However, they do not explain the inability of previous vaccines to elicit bNAbs to epitopes such as VRC01 that were present in most gp120 vaccines expressed in normal CHO cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496728	However, in stable expression, with the increase of the expression levels of SEAP and IL-3, the copy number of genes increases, which indicates that the stable expression levels of SEAP and IL-3 in CHO-KO cells are related to the copy number of genes compared with those of CHO-WT cells, and the increase of transient ex...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	A maximum z projection is shown; scale bar, 10 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "maximum", "z", "projection", "is", "shown", ";", "scale", "bar", ",",...
PMC2193049	Therefore, we envisage two possibilities: First, the remaining PGPH activity not only cleaves at the COOH terminus of glutamic acid but may be more permissive and also cleave after nonacidic amino acid residues, or, second, the catalytic subunits responsible for the BrAAP and SNAAP activities of the proteasome, in addi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Rapid cellular mitosis makes children more susceptible to CT and hence to OM than adults.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rapid", "cellular", "mitosis", "makes", "children", "more", ...
PMC11587541	and fusion at their ends.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "fusion", "at", "their", "ends", "." ] } ]
PMC9812014	Other than these alkaloids are actively being utilized for ages for treating malarial infections and are a broad source of medicinal compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "tha...
PMC11535726	All these species have been reported with their asexual morph, either exhibiting the dendryphiopsis-like or sporidesmium-like morphologies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "these", "species", "have", "bee...
PMC9429973	We tested the long-term HSC expansion potential in the rMSC-based co-culture system, phenotypically using FACS based proliferation analysis and functionally using limiting dilution and colony forming assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Elemental analysis (%) found: C, 48.1; H, 3.2; N, 3.2; S, 8.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elemental", ...
PMC11543935	The developed parts used in the setup, like the biopsy punch, have direct contact with cellular components, which makes the biocompatibility of the printing material necessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411004	CHO cell line instability can be affected by chromosomal rear-rangement, DNA methylation, and transcriptional/translational silencing, leading to the production instability (cell clonal heterogeneity) (Cordova et al. 2024).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11243198	Hh/GLI activation has been observed in various human tumor types .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hh/GLI", "activation", "has", "been", "observed", "in", "various", "human", "tumor", "types", ...
PMC11763126	B Volcano plot showing changes in mRNA expression in ccRCC cells following CBDP1 treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Volcano", "plot", "showing", "changes", "in", "mRNA", "expr...
PMC9261184	The loading and unloading manifolds were screened during use (before, during, and immediately after the loading and unloading operations).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10538569	1.5 µl Vybrant DiD-Cell Labeling Solution (ThermoFisher) was added for 10 minutes at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1.5", "µl", "Vybrant", "DiD-Cell", "La...
PMC6442998	αSMA mRNA level was significantly higher (fold change of 4) in GIST48 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "αSMA", "mRNA", "level", "was", "significantly", "higher"...
PMC11705862	Recent literature further suggests that the mechanisms for the association between T2D and high AD risk revolves around glucotoxicity, and its downstream consequences like insulin resistance, impaired insulin receptor signaling, advanced glycation end products, or inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sixteen (10%) pts discontinued before randomization (7 SD, 3 PD, 3 AE, 1 withdrawal, 2 poor compliance) and 141 (89%) were randomized to either RIT (71) or ASCT (70) (randomized population).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Retrospective cohort, in patients with cancer diagnosis who received transfusions in the last 6 months of life, a non-probabilistic sampling of consecutive cases was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017	Notably, among patients with available WGS data, all 7 patients who progressed without BCMA antigen escape after receiving anti-BCMA TCEs (MM-19, MM-14, MM-11, MM-07, MM-20, MM-18, and MM-13) (Figure 1A) were primary refractory or relapsed within 6 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Centrifuge cell suspension at approximately 450 × g for 5 min at 4°C .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centrifuge", "cell", "suspension", "at", "approximately", "450", ...

PMC11687663

Along with other phytoconstituents (B1-B7 and B11), Schaftoside (B7) violate the Lipinski’s rule of five whereas, Quercetin (B12) obey the rule.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9985266

In conclusion, our study shows that IL-27 upregulates MEG3 expression by inhibiting DNMT1-mediated lncRNA MEG3 promoter methylation, which in turn inhibits the ERK/p38 signaling pathway to induce autophagy to attenuate BLM-induced PF, that provides help to elucidate the potential mechanism by which IL-27 attenuates PF.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11394227

In normal circumstances, GSH accounts for 90–95% of the tGSH, with less than 70% resulting in significant oxidative stress-related damage.

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PMC6133382

To be a viable substrate for biopharmaceutical production, the growth and protein yield of the knockout line had to be comparable to the parental line.

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PMC11252553

However, radiotherapy can negatively impact neighboring healthy tissues, leading to the necessitation of dose limitation to minimize harm.

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PMC9436459

Seven type I MDAAs might be variations of some classic MDAAs, in which the phenyl moieties at C-8" or the benzoyl moieties at C-4" is missing, as exemplified by compounds 160 − 161 or 162 − 166 [123, 138–140], respectively.

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PMC11317131

The cells were cultured in the presence of the phage overnight and the next day the phage concentration was measured using the activity-independent plaque assay, similar to above.

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PMC11453346

M. Tsachaki: None.

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "M.", "Tsachaki", ":", "None", "." ] } ]

PMC6627640

However, the relationship between TGCT epigenetics and curability and chemoresistance is largely uncharacterized and has been limited to a few studies related to gene specific DNA methylation .

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PMC11267830

By constructing in vivo and in vitro models with RBM39 interference, we found that RBM39 is crucial for the proliferation and survival of T-ALL tumor cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11489275

Based on the first to 14th day after admission, the two adjacent days were combined into one group.

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PMC7305184

30 generations of CTRL and EP group are shown at different electric fields.

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PMC11700247

Moreover, the group that received T cells from the combination-treated donors showed increased infiltration by CD8 T cells (Figure 4D) and cytotoxic T cells within the tumor (Figure 4E).

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PMC11700340

Multiple studies indicate that the cytoprotection conferred by HSP is partially mediated by suppressing spontaneous and therapy-induced apoptosis.

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PMC11803918

This discovery led us to formulate a more potent immunotherapy approach using γδ-T exosomes.

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PMC11337594

This lays the foundation for TER as a potential anti-melanoma drug in the future.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "lays", "the", "foundation", "for", "TER", "as", "a", ...

PMC10887351

I, Gα.q, and Gα.12) to which the receptor is coupled .

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PMC6379402

These networks, represented by their adjacency matrices, Ai, are simultaneously decomposed as the product of three factors, G, Si, and G, as detailed in Methods (illustrated in the middle panel).

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PMC8759873

Blow the cells repeatedly with a pipette and then move to a 1.5 ml Eppendorf tube.

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PMC9429973

Median RFS was 27.8m, 15.4m, 7.3m, and 5.2m in the IA MRD(-), Lo + VEN MRD(-), IA MRD(+), and Lo + VEN MRD(+) groups, respectively.

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PMC11658074

These results suggest that AT has a protective effect on the skin.

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PMC11772585

Mix the contents thoroughly, then incubate in a water bath at 37 °C for 10 min.

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PMC11725127

A peptide with a calculated mass of 1321.70 Da, which is 628 Da larger than the Cys284-containing peptide NSILQCLSN with a calculated mass of 693.70 Da was identified.

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PMC9429973

PTK2B was also post-translationally stabilized in TKI resistant cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTK2B", "was", "also", "post-translationally", "stabilized", "in", "TKI", "resistant", "cells", "." ] ...

PMC11772585

Increased expression of HK2 has been identified in several cancer types, such as melanoma , glioma , and bladder cancer , impacting both glycolysis and mitochondrial function.

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PMC9856122

Protoberberine alkaloids show prominent effects against HSV, HBV, SARS-CoV, SARS-CoV-2, and HCMV.

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PMC7039683

gkmSVM were performed to generate a scoring vector (parameter: K = 6, L = 10).

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PMC10849234

18 hours later, transduced cells were centrifuged (100G; 10 minutes) and resuspended in selection media (supplemented RPMI-1640).

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PMC11406030

This work was partially funded by a grant from Temple Therapeutics (MA, USA).

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PMC9429973

The sudden rise of transaminases and bilirubin levels was registered in 3 patients and led to treatment discontinuation.

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PMC10547921

PNU-159682 caused S-phase cell cycle arrest due to its DNA-damaging activity, while MMAF simultaneously inhibited tubulin polymerization and caused G2/M-phase cell cycle arrest.

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PMC11507371

Mean intensities of proteins associated with Nrf2 and NF-κB signalling in A431 and HaCaT cells. (

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PMC8662250

For these experiments, undifferentiated Caco‐2 cells were cultured onto coverslips until confluence and divided into four groups: 1) Vehicle, 2) 10 ng/ml SP, 3) 10 ng/ml SP plus 10 M CBD, and 4) 10 ng/ml SP with 10 M CBD plus 9 nM GW9662 antagonist PPAR‐γ.

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PMC11765988

Overlap with certain connective tissue diseases is possible, as antinuclear antibodies have been detected in some cases .

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PMC11496491

GO enrichment analysis results show the top 10 Term analysis charts that are most significant in terms of cell components. (

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PMC11761919

Additionally, significantly increased mRNA levels of IL-2, IFN-γ were observed in the spleen tissues of chickens immunized with Micro-E/Fiber2-PINs.

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PMC11730311

Interestingly, the lower abundance of C-terminal fragments identified from hαCGRP8-37S19K-C20DA-γGlu compared to hαCGRP8-37N25K-C20DA-γGlu suggest that positioning the C20DA-γGlu conjugation within the LLSR motif offer greater protection against in vivo cleavage in this region.

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PMC11367146

VTE did not show any cytotoxicity and inhibited the migration of SW982 cells.

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PMC10957991

Bar 140 um. (

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PMC9429973

Crude numbers of HRU were determined by the number of inpatient admissions and outpatient visits in the first year after diagnosis or cohort entry and for the entire follow-up period for each season.

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PMC10850553

The absence of the deposition of complement C3 or C5b-9 complex in intracranial aneurysm lesions. (

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PMC9429973

The Top 10 list is predominantly about improving pharmacological treatments for multiple myeloma.

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PMC11342785

These outposts are thought to act as hubs that concentrate TPPP with interaction partners, including the condensate-forming Golgi matrix protein GM130 (29, 46, 47).

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PMC9429973

Image: Summary/Conclusion: These data represent complete analysis of all patients in the induction phase of MAGNIFY which continue to support that R is active with a tolerable safety profile in patients with R/R FL grade 1–3a and MZL, including rituximab-refractory, double-refractory, and early relapse patients.

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PMC11650848

The WISC-IV, which is appropriate for children ages 6 years to 16 years and 11 months, encompasses a range of tests including Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed (which included subtests for symbol search and cancellation), along with providing a combined full-scale IQ score ...

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PMC9429973

In 73% and 40% of pts in co2, POM dose was increased to 1 mg and 2 mg QD after cycle 3 and 6, respectively.

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PMC11676674

MMC has been demonstrated to possess genotoxic effects in both in vitro (mammalian cells) and in vivo (animals) studies, and it has been clearly proven to be a carcinogenic substance .

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PMC11731161

Slides were incubated with primary antibody against USP7 (1:100, Santa Cruz) or Ki67 (1:200, Proteintech) overnight at 4 °C.

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PMC11786156

CD54 is involved in cell-to-cell adhesion and proliferation of cultured cells, such as Raji cells (a human Burkitt lymphoma cell line) and A20 cells (a mouse B-cell lymphoma cell line) by activating ERK and Lyn.

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PMC11629143

For selection, media was supplemented 48‐h post‐transfection with 250 µg/mL Zeocin (for dCas9), 400 µg/mL G418 (for dCas9‐p300) or 100 µg/mL Hygromycin (for dCas9‐HDAC1) every 2–3 days for 2 weeks.

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PMC11295144

The percentage of synapses incorporating active terminals in these experiments was ~10% (control/NL2), 24% (α4β3δ-GABAAR/NL2), and 30% (α2β2γ2-GABAAR/NL2).

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PMC9429973

Methods: This is a retrospective, descriptive study based on patients data diagnosed with COVID- 19 in Quito-Ecuador in Hospital Metropolitano who required general hospitalization and/or intensive care unit; each of them received convalescent plasma from patients with previous infection.

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PMC11267830

c Overlap of splicing events (exon skipping and intron retention) with up- or downregulated proteins after 16 h of indisulam treatment.

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PMC9688728

However, the role of this metabolite is not fully understood, and there is evidence that cadaverine has a positive effect on the treatment of breast cancer through reduced metastasis .

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PMC11461833

On the basis of these findings, we hypothesized that STXBP5 and progerin may interact.

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PMC6600592

Pale yellow liquid, yield 70.8%.

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PMC9429973

EVcargo is an indirect and more affordable measure to infer EV protein load compared to mass-spectrometry.

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PMC11750696

In recent studies, the UPR and ER stress are recognized as pivotal regulators that shape the maturation and functional dynamics of T helper lymphocytes.

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PMC7294030

These pathways are important in tumor progression and metastasis (Reddy et al., 2003).

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PMC11711347

The interaction of Oxygen with the Ni metal ions is indicated by its absorption peak at 387 cm (Figure 4).

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PMC9164404

This work highlighted the use of multi-omics for the mechanism study of Abplatin.

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PMC11755467

Unlike nalidixic acid, Enoxacin contains 6-fluoro- and 7-piperazin-1-yl substituents that are capable of forming additional interactions with target molecules.

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PMC10507284

Therefore, we analyzed the correlation between TROAP and preclinical and clinical drugs to discover potential treatments for STS.

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PMC9429973

NOTCH3 and RELN mutations were only 3/20 (10%) in those who did not reach 12M-MMR group.

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PMC9917080

In our experiments, all studied agents led to an increase in SELENON expression, but the SeSo nanocomplex turned out to be especially effective, which in the case of astrocytes can be regarded as a positive effect aimed at enhancing their viability.

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PMC10698968

They are a fast-growing cell line, composed mostly of small spindle-shaped cells, with few larger multinucleated cells, likely due to events of aberrant mitosis.

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PMC10969097

Traditional cancer treatment primarily relies on surgery, radiotherapy and/or chemotherapy .

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PMC11676670

This subtype has been characterized by the following characteristics: frequent mutations in key genes, such as TP53, NF1, BRCA1, BRCA2, RB1, CDK12, FAT3, and CSMD3, coupled with chromosomal copy number variations and genomic duplications .

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PMC11463018

While the cyclopropyl group of Filgotinib pointed towards an open space (solvent-exposed region) that could possibly accommodate a relatively large motif.

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PMC11040965

P < .05, **P ≤ .01, Wilcoxon signed-rank test We previously found that low levels of proteasome subunits reduced the recognition of MM plasma cells by tumor plasma cell-specific cytotoxic CD8 T lymphocytes .

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PMC11502327

Astragalus polysaccharide (APS), a natural antitumor agent isolated from Astragalus membranaceus, has been shown to target the tumor suppressor F-box and WD-40 domain protein 7 through the regulation of miRNA, mediating miR-27a/FBXW 7 axis, which plays an anti-OC cell growth role in vitro (44).

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PMC9577200

The effect of different concentrations of CS on the viability of the HeLa cell line was assessed by CCK-8.

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PMC8345486

Doxorubicin HCl (99%; DOX042) was purchased from BioSchop Canada Inc. (Burlington, ON, Canada).

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PMC10154881

In 2015, a herpes simplex virus‐based oncolytic virus received its first approval for melanoma treatment in the USA and Europe.

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PMC11721295

To better understand KRAS-dependent changes occurring in the tumor and tumor microenvironment, we utilized scRNA-seq.

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PMC11683240

The transport of PTS1 into the host cell cytosol relies on the assistance of host cell chaperones and enzymes that aid in the folding of proteins (25, 26, 27, 28).

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PMC7987994

Based on our results, we strongly recommend not to use only the usual statement “in vitro cytotoxicity was performed according to ISO 10,993 standard”, but to thoroughly describe all the aforementioned conditions used during the cytotoxicity testing including catalogue numbers of media.

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PMC11627060

The average size of the synthesized BSA NPs is less than 200 nm, while TQ–BSA NPs had an average size of 187 ± 8 nm.

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PMC6133382

However, they do not explain the inability of previous vaccines to elicit bNAbs to epitopes such as VRC01 that were present in most gp120 vaccines expressed in normal CHO cells.

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PMC11496728

However, in stable expression, with the increase of the expression levels of SEAP and IL-3, the copy number of genes increases, which indicates that the stable expression levels of SEAP and IL-3 in CHO-KO cells are related to the copy number of genes compared with those of CHO-WT cells, and the increase of transient ex...

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PMC11224020

A maximum z projection is shown; scale bar, 10 µm.

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PMC2193049

Therefore, we envisage two possibilities: First, the remaining PGPH activity not only cleaves at the COOH terminus of glutamic acid but may be more permissive and also cleave after nonacidic amino acid residues, or, second, the catalytic subunits responsible for the BrAAP and SNAAP activities of the proteasome, in addi...

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PMC9429973

Rapid cellular mitosis makes children more susceptible to CT and hence to OM than adults.

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PMC11587541

and fusion at their ends.

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PMC9812014

Other than these alkaloids are actively being utilized for ages for treating malarial infections and are a broad source of medicinal compounds.

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PMC11535726

All these species have been reported with their asexual morph, either exhibiting the dendryphiopsis-like or sporidesmium-like morphologies.

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PMC9429973

We tested the long-term HSC expansion potential in the rMSC-based co-culture system, phenotypically using FACS based proliferation analysis and functionally using limiting dilution and colony forming assays.

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PMC10988555

Elemental analysis (%) found: C, 48.1; H, 3.2; N, 3.2; S, 8.0.

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PMC11543935

The developed parts used in the setup, like the biopsy punch, have direct contact with cellular components, which makes the biocompatibility of the printing material necessary.

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PMC11411004

CHO cell line instability can be affected by chromosomal rear-rangement, DNA methylation, and transcriptional/translational silencing, leading to the production instability (cell clonal heterogeneity) (Cordova et al. 2024).

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PMC11243198

Hh/GLI activation has been observed in various human tumor types .

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PMC11763126

B Volcano plot showing changes in mRNA expression in ccRCC cells following CBDP1 treatment.

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PMC9261184

The loading and unloading manifolds were screened during use (before, during, and immediately after the loading and unloading operations).

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PMC10538569

1.5 µl Vybrant DiD-Cell Labeling Solution (ThermoFisher) was added for 10 minutes at 37°C.

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PMC6442998

αSMA mRNA level was significantly higher (fold change of 4) in GIST48 cells.

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PMC11705862

Recent literature further suggests that the mechanisms for the association between T2D and high AD risk revolves around glucotoxicity, and its downstream consequences like insulin resistance, impaired insulin receptor signaling, advanced glycation end products, or inflammation .

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PMC9429973

Sixteen (10%) pts discontinued before randomization (7 SD, 3 PD, 3 AE, 1 withdrawal, 2 poor compliance) and 141 (89%) were randomized to either RIT (71) or ASCT (70) (randomized population).

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PMC9429973

Methods: Retrospective cohort, in patients with cancer diagnosis who received transfusions in the last 6 months of life, a non-probabilistic sampling of consecutive cases was performed.

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PMC11738017

Notably, among patients with available WGS data, all 7 patients who progressed without BCMA antigen escape after receiving anti-BCMA TCEs (MM-19, MM-14, MM-11, MM-07, MM-20, MM-18, and MM-13) (Figure 1A) were primary refractory or relapsed within 6 months.

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PMC11758416

Centrifuge cell suspension at approximately 450 × g for 5 min at 4°C .

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