OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11412721	Asynchronous MEFs were exposed to 0–10 Gy γ-irradiation, then after 24 hr cells were labeled with BrdU for 1 hr and analyzed by FACS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11786767	The enlarged chromosome segment shows the enriched biotin-DHPE signals at the perichromosomal layers during anaphase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "enlarged", "chromosome", "segment", "shows", "the", ...
PMC9429973	Methods: ABCB1 gene expression was absolutely quantified in 28 primary AML samples collected prior to any treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "ABCB1", "gene", "expre...
PMC9429973	Methods: We applied a single-cell (sc) sequencing method that simultaneously measures gene expression and full-length transcripts to determine genotype on samples from patients with progressive CLL with long term follow-up on trials of continuous VEN therapy (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Most common Grade ≥3 hematologic AEs were neutropenia (44%), thrombocytopenia (41%), and anemia (37%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9964635	The versatile nature of 1,2,4-triazole has been reported to be of great importance in medicinal chemistry, such as for its anti-cancer , anti-fungal , anti-bacterial , anti-microbial, and anti-tumor properties , as well as pyrophosphatases and phosphodiesterase .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cytogenetic analysis revealed trisomy 19 as the sole abnormality in 10 (12.5%), additional abnormalities in a non-complex karyotype in 8 (8%) and a complex karyotype in 79 (81.5%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	Epidermal thickness and epidermal necrosis did not differ between Ac-DEVD-CHO-treated mice and PBS-treated mice according to H&E staining assay (Fig. 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epiderm...
PMC3765139	Limiting dilution analysis and clonogenic assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limiting", "dilution", "analysis", "and", "clonogenic", "assay", "." ] } ]
PMC7709199	There are five putative N-glycosylation sites in this fragment according to the NetNGlyc 1.0 server (Blom et al., 2004 ▸).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There",...
PMC9429973	Summary/Conclusion: The financial burden of individuals affected by SCD in GCC region is on rise with highest burden in Bahrain, followed by UAE then Oman.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	We applied ultrasound microbubble gene transfection technology and liposome gene transfection technology to transfect pEGFP-VHL into 786-0 cells, which we then measured the transfection rate by immunofluorescence .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O"...
PMC11089031	Fig. 2ZNF692 transcript level in clear cell renal cell carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2ZNF692", "transcript", "level", "in", "clear", "cell", "renal", "cell", "carcinoma", ...
PMC9429973	Neither overall survival (G: median 9.1 months, TC: median 8.3 months, p=0.61, HR:0.94 with 95% CI: [0.74-1.19]) nor leukemia-free survival (LFS) (G: median 5.7 months, TC: median 5.9 months; p=0.38) demonstrated a significant difference between the two groups and subgroup analyses did not suggest a difference between ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The molecular mechanism underlying RS remains to be explored further.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molecular", "mechanism", "underlying", "RS", "remains", "to", "be", "explored", "further"...
PMC9429973	Combination of Ola and ZnSO4 reduced 2.9-fold, 1.6-fold, and 7.5-fold the IC50 in HEL, NB-4, and K-562 cell lines, respectively, after 48h.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O"...
PMC9119314	It was also shown that the antiplasmodial mode of action of 1 involves a chloroquine-like mode of action (inhibition of hemozoin formation) that is independent of interactions with DNA (Wright et al., 2001), suggesting the possibility that it may be possible to prepare analogues of 1 that do not intercalate into DNA bu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4839679	Genes involved in cell adhesion featured prominently in our transcriptional dataset and overlapped with genes uniquely regulated by PBRM1 in clinical specimens of ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11394730	The results of a pilot investigation indicated that epicatechin, but not catechin, the two naturally occurring antioxidants in green tea, increased the anticancer activity of panaxadiol (PD), a purified ginseng component.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197	In HCT-116 cells, hypoxic stress induces transcriptional activation of PPARβ/δ.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "HCT-116", "cells", ",", "hypoxic", "stress", "induces", "transcriptional", "...
PMC9429973	The most common subsequent treatment regimens based on hierarchy were daratumumab (22.1% claims; 17.4% EHR), carfilzomib (10.6% claims; 18.4% EHR), and pomalidomide based (12.3% claims; 8.7% EHR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	In the early stages of primary cilia assembly, loss of Kat2b disrupts α-tubulin acetylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "early", "stages", "of", "primary", "cilia", ...
PMC9688728	Methyl esters of 20 fatty acids were used as internal standards.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methyl", "esters", "of", "20", "fatty", "acids", "were", "used", "as", "internal", ...
PMC9512971	The primary efficacy endpoint was the time to the first two consecutive negative tests for SARS-CoV-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "efficacy", "endpoint", "was", "the",...
PMC9429973	Pts were grouped based on sequence of therapy and response to frontline treatment for additional subgroup analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "were", "grouped", "based", "on", "se...
PMC10545062	The left external jugular vein was cannulated with a triple lumen catheter for mIVF, vasoactive medication administration, and central venous pressure (CVP) measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486	LA45 antigens could not be detected on the surface and the cytoplasm of resting peripheral blood lymphocytes (PBLs) or bone marrow mononuclear and polymorphonuclear cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	There are several ways to overcome fratricide, including artificial reduction of surface target antigens (gene-editing and ER and/or Golgi-retaining) and natural selection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11732628	Micro RNA-490-3p (miR-490-3p) is associated with a variety of malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Micro", "RNA-490", "-", "3p", "(", "miR-490", "-...
PMC11680982	This implies a potential effect of HER2-low status on the response to CDK4/6 inhibitors in HR/HER2- breast cancer, possibly associated with resistance mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11525028	NAT10, ATF4, and ASNS protein levels in 143B (left) and HOS (right) cells treated with paliperidone or AG-401 (24 h) at the indicated concentrations. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9261184	To understand the GHG results in context, this study is compared to three recent desk-based studies, Roman-White et al., NETL, and thinkstep, as shown in Figure 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684269	Among these, T cell metabolic modulation is widely discussed, and these outstanding achievements may shed light on the treatment of kidney diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11754094	Determining the frequency of deletion events >100 bp is challenging using short-range high-throughput sequencing methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Determining", "the", "frequency", "of", "deletion", "e...
PMC9429973	The case selection process is summarized in Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "case", "selection", "process", "is", "summarized", "in", "Figure", "1", "." ] } ]
PMC11547972	The combined use of low-dosed amygdalin and SFN could, therefore, be beneficial as a complementary option to treat RCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", ...
PMC11345828	Anhydrous MeCN (80 mL) was added and the solution was stirred at 80 °C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anhydrous", "MeCN", "(", "80", "mL", ...
PMC9429973	DA treatment was started at 100mg once daily after molecular relapse was confirmed, and continued for at least 12 months after achieving ≥ MR4 until DISC for TFR2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3730428	FLIP is mainly expressed as two splice forms: a long form FLIP(L) and a short form FLIP(S).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FLIP", "is", "mainly", ...
PMC11248911	The CHARMM-GUI solution builder includes five steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CHARMM-GUI", "solution", "builder", "includes", "five", "steps", "." ] } ]
PMC6600253	Mutations in the RAS oncogene are common in many human cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "in", "the", "RAS", "oncogene", "are", "common", "in", "many", "human", ...
PMC9596868	Representative fluorescence microscopy images of A2780 cells treated with 2 μM MST-312 or 15 μM quercetin and their combination for 48 h. (F) Quantification of γ-H2AX foci positive cells in A2780 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Investigate the ability of the CD20-targeted T-cell-engaging bispecific antibody glofitamab (CD20-TCB) to overcome T cell exhaustion and tumor microenvironment (TME)-mediated immunosuppression in CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	H-NMR (400 MHz, D2O) [ppm]: δ= 2.63 (Hc + Hi, t, 23H), 2.66 (Ha, s, 4H), 2.97 (Hg, t, 8H), 3.26 (Hb, t, 10H), 3.34 (Hh, t, 12H), and 3.64 (Hf, t, 8H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700247	These consistent findings were also observed in vivo (Figure 5E-F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "consistent", "findings", "were", "also", "observed", "in", "vivo", "(",...
PMC11012012	Our results showed that SLAMF3/CD229 is significantly upregulated in CLL in comparison with normal B cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "showed", "that", "SLAMF3/CD229", "is...
PMC9621239	The ratios of cells in the S phase among the Vector, WT, SM, DM and TM groups are presented on the right at the top of the panel in (A) or (B); Each symbol represents an individual experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We found that the TUG and MNA-SF scores could stratify the risk of grade ≥ 3 AEs in the IMWG GA Int-fit group (P < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643491	To further translate the differences in uptake into biological effects in drug delivery, we adapted the heat-induced stretching method from PS to biodegradable, poly(lactic-co-glycolic acid) (PLGA) particles loaded with paclitaxel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	Results are averaged over 20 simulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "averaged", "over", "20", "simulations", "." ] } ]
PMC11026382	It is possible that these mutations caused a growth rate defect through toxicity linked to DHFR mis-folding and aggregation, a mechanism not captured by our model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	TWIST1′s recognition as miR-204–3p's downstream target sheds light on ccRCC's molecular dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TWIST1′s", "recognition", "as", "miR-204–3p", "'s", "downstream", "tar...
PMC11641630	The MB49 cell line is extensively used to study the murine orthotopic model of the disease.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MB49", "cell", "line", "is", "extensiv...
PMC11750165	Although PEX1 morphants showed phenotypical similarity to Jagged2 morphants, the number of KA” neurons in PEX1 morphants was increased approximately 1.4±0.2-fold, and that in PEX1 deletion mutants was only increased approximately 1.2+0.01-fold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055323	h Venn plot shows the intersection of CTCF binding sites in BJ cells with the overexpression of SS18-SSX1 and SS18(YA)-SSX as control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "h", ...
PMC11451940	Subsequently, the cells were washed once with PBS (0.1 M, pH 7.4), and cell cycle analysis was conducted using the BD Cycletest™ Plus DNA kit (Becton Dickinson, USA) following the manufacturer's protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765678	The concentration of protein in the samples was determined using the PierceTM BCA Protein Assay (Thermo Fisher, 23225).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "concentration", ...
PMC11429241	Nevertheless, the deviations were minuscule and had a minimal impact on the mechanical stability of the structures or shape fidelity, as evident from the SEM analysis (Figure 4b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	At the same time, the selenium-sorafenib nanocomplex was more pronounced and selectively activated the Ca signaling system of A-172 glioblastoma cells, compared to “naked” SeNPs, causing higher amplitude Ca responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11731161	Using Co-IP assay, we confirmed that USP7 possesses an endogenous interaction with XPO1 in NCI-H929 and MM.1S cells (Fig. 3E, F), while SEL substantially disrupts this interaction (Fig. 3G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "...
PMC11680982	T47D cells were treated with 100 nM fulvestrant (MedChem Express, USA) and 150 nM palbociclib (MedChem Express, USA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11658074	AT-EVs increased Col1A1 levels while decreasing MMP9 and CDKN1A levels in NIH3T3 cells, as confirmed by both qRT‒PCR and WB (Fig. 3b‒d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11756514	The cell lines (200,000 cells) were incubated with 10 µg/mL biotin-conjugated neoglycoproteins (Fuc-BSA, Man-BSA, GlcNAc-BSA, GalNAc-BSA, Gal-BSA or BSA) in HBS+ for 30 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727907	The importance of the RPE in the retina is also related to its metabolic contribution to retinal function maintenance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "importance", "of", "the", ...
PMC11718031	Monoclonal antibodies (mAbs) contribute to a large fraction of therapeutics on the market today (Ecker et al. 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Monoclonal", ...
PMC11615828	Although the evidence is indirect, MTs undergo different post‐translational modifications and have preferential affinities to different types of motor proteins that may act as railways for distinct transport pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	While the entire differentiation process can be divided into three major steps of mesodermal, hematopoietic and OC differentiation, each step can be further subdivided into steps that are recapitulated in ontogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	B Sequence logo demonstrating conservation of positively charged amino acids (blue) within the NLS region of ORF4b from the merbecoviruses in panel A (see Supplementary Fig. 10 for the full multiple sequence alignment).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901	They were seeded in 25 cm flasks and maintained in a humidified atmosphere of 5% CO2 at 37 °C (Heraeus Hera Cell 240 incubator, Langenselbold, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10728535	COL4A6 is involved in ECM‐receptor interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COL4A6", "is", "involved", "in", "ECM‐receptor", "interaction", "." ] } ]
PMC8414691	P < 0.05; P < 0.005; and *P < 0.0005 compared with the mock group by Fisher’s exact test RNAi-mediated depletion of DOM-A affects mitosis and cytokinesis in Drosophila S2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5854676	θ is diffraction angle measured in radians.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "θ", "is", "diffraction", "angle", "measured", "in", "radians", "." ] } ]
PMC10877303	According to the crystal structure of 3CL, each monomer remains perpendicular in the homodimer consisting of a core chymotrypsin-like fold assembled by two domains, designated domains I and II, consisting of residues 1–187, a prolonged connecting loop consisting of residues 188–204, and domain III or C-terminal alpha-h...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657744	P < 0.05; , P < 0.01; *, P < 0.001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", "*", ...
PMC9429973	There is also no data comparing CPX-351 to FLAG-IDA which is used in our institution front line for high-risk AML Aims: The objective of our multi-centre study was to assess outcomes of CPX-351 and then compare these outcomes in patients who received FLAG-IDA and 3 + 7 for high risk AML(tAML and AML-MRC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	197 have undergone at least one treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "197", "have", "undergone", "at", "least", "one", "treatment", "." ] } ]
PMC11629192	When the response to the first-line therapy is inadequate or when the disease is severe or relapsing, escalation of immunotherapy to the second-line immunotherapy is needed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	This activity is linked to the generation of gIII such that successful integrases capable of acting on their att sites enable propagation of infectious phage harboring their coding sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10898159	GIST is inherently resistant to radiotherapy and cytotoxic drug , albeit some end-stage cases with GIST treated by radiotherapy can achieved palliative pain-relief [226–228].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10507284	In sum, these above results imply that the TROAP‐derived signature has a superior predictive capacity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "sum", ",", "these", "above", "results", "i...
PMC11674146	B, C) Relative CLP36 protein expression level in lymphoma cells calculated based on immunoblotting assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "C", ")", "Relative", "...
PMC11747467	Next, we established the hierarchical clustering dendrogram of the 1-TOM matrix to determine coexpression modules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "established", "the", "hierarchical"...
PMC10958426	The genes located in duplication regions express significantly higher than the genes in noCNV regions (P = 4.9 × 10) and deletion regions (P = 4.9 × 10), with genes in deletion regions have the lowest expression levels (Fig. 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	LOS and PFD increase the activation of SOD and CAT while decreasing MDA content in A549-treated BLM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "LOS", "and", "PFD", "increase", "the", ...
PMC8735881	Effects of CMI constructs on the surface expression of CD4, CCR5, and CXCR4 in transduced TZM-bl cells were detected by FACS analysis using a PE-conjugated anti-human CD4, CCR5, or CXCR4 antibody and judged by fluorescence intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10850553	The incubation mixture was then subjected to a western blot analysis using mouse monoclonal anti-human C5a/C5a des-Arg antibody (clone 2952, #HM2079, Hycult Biotech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	Two cycles with circular paths represent the ecDNA structure. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "cycles", "with", "circular", "paths", "represent", "the", "ecDNA", "structure", ".", ...
PMC11448304	Our analysis revealed 920 significantly differentially expressed genes and 699 proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "analysis", "revealed", "920", "significantly", "differentially", "expressed", "genes", ...
PMC8414691	Cit-K is the main abscission regulator capable of physically and functionally interacting with the actin-binding protein Anillin, a crucial component of the contractile ring and midbody .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Mixtures containing vehicle without compound served as a negative control, while mixtures containing no protein served as a positive control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mixtures", "containing"...
PMC10850553	The tag count of each known factor mediating the migration of neutrophils like C5ar1 from two-independent data sets is shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tag", "count", ...
PMC9786247	Thereafter, the cells were washed with PBS and subsequently lysed with RLT buffer (RNeasy Mini Kit; Qiagen, Hilden, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11792766	HepG2 and Caco‐2 cells were seeded in 96‐well plates at a density of 25,000 cells per well in culture medium.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HepG2", "and", ...
PMC11078693	Otherwise, cap the tube, then shake and rotate it to position the cover glass correctly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Otherwise", ",", "cap", "the", "tube", ",",...
PMC8009078	The ∆H is the term in which molecular mechanical energy (∆EMM) and solvation free energy (∆Esol) are involved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "∆H", ...
PMC11597291	The test was repeated thrice, and the percent of hemolysis was calculated from the following equation:(1)Hemolysis %=AnCGO−AnegativeApositive−Anegative×100 where AnCGO, Apositive, and Anegative are the absorbances of hemoglobin contained in the supernatant of the nCGO and nCGO-PEG particles, in the negative control and...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8358176	Relative mRNA levels of TNF family genes in the MWCNT- and SWCNT-exposed Jurkat cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Relative", "mRNA", "levels", "of", "TNF", "family", ...
PMC7868205	The IC50 value for the hydrosol against HEK-293 cells was 0.622 µL/mL (622 ppm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "value", "for", "the", "hydrosol", ...
PMC8382973	The datasets presented in this study can be found in online repositories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "datasets", "presented", "in", "this", "study", "can", "be", "found", ...
PMC11701801	A, Volume of tumor xenografts derived from SMARCA4/SMARCA2-deficient DMS114 cell lines and harvested from mice treated once daily with 30 mg/kg CP-C27.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11412721

Asynchronous MEFs were exposed to 0–10 Gy γ-irradiation, then after 24 hr cells were labeled with BrdU for 1 hr and analyzed by FACS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11786767

The enlarged chromosome segment shows the enriched biotin-DHPE signals at the perichromosomal layers during anaphase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "enlarged", "chromosome", "segment", "shows", "the", ...

PMC9429973

Methods: ABCB1 gene expression was absolutely quantified in 28 primary AML samples collected prior to any treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "ABCB1", "gene", "expre...

PMC9429973

Methods: We applied a single-cell (sc) sequencing method that simultaneously measures gene expression and full-length transcripts to determine genotype on samples from patients with progressive CLL with long term follow-up on trials of continuous VEN therapy (Figure 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Most common Grade ≥3 hematologic AEs were neutropenia (44%), thrombocytopenia (41%), and anemia (37%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9964635

The versatile nature of 1,2,4-triazole has been reported to be of great importance in medicinal chemistry, such as for its anti-cancer , anti-fungal , anti-bacterial , anti-microbial, and anti-tumor properties , as well as pyrophosphatases and phosphodiesterase .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Cytogenetic analysis revealed trisomy 19 as the sole abnormality in 10 (12.5%), additional abnormalities in a non-complex karyotype in 8 (8%) and a complex karyotype in 79 (81.5%) patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11762280

Epidermal thickness and epidermal necrosis did not differ between Ac-DEVD-CHO-treated mice and PBS-treated mice according to H&E staining assay (Fig. 4D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Epiderm...

PMC3765139

Limiting dilution analysis and clonogenic assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limiting", "dilution", "analysis", "and", "clonogenic", "assay", "." ] } ]

PMC7709199

There are five putative N-glycosylation sites in this fragment according to the NetNGlyc 1.0 server (Blom et al., 2004 ▸).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There",...

PMC9429973

Summary/Conclusion: The financial burden of individuals affected by SCD in GCC region is on rise with highest burden in Bahrain, followed by UAE then Oman.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8759873

We applied ultrasound microbubble gene transfection technology and liposome gene transfection technology to transfect pEGFP-VHL into 786-0 cells, which we then measured the transfection rate by immunofluorescence .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O"...

PMC11089031

Fig. 2ZNF692 transcript level in clear cell renal cell carcinoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2ZNF692", "transcript", "level", "in", "clear", "cell", "renal", "cell", "carcinoma", ...

PMC9429973

Neither overall survival (G: median 9.1 months, TC: median 8.3 months, p=0.61, HR:0.94 with 95% CI: [0.74-1.19]) nor leukemia-free survival (LFS) (G: median 5.7 months, TC: median 5.9 months; p=0.38) demonstrated a significant difference between the two groups and subgroup analyses did not suggest a difference between ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The molecular mechanism underlying RS remains to be explored further.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molecular", "mechanism", "underlying", "RS", "remains", "to", "be", "explored", "further"...

PMC9429973

Combination of Ola and ZnSO4 reduced 2.9-fold, 1.6-fold, and 7.5-fold the IC50 in HEL, NB-4, and K-562 cell lines, respectively, after 48h.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O"...

PMC9119314

It was also shown that the antiplasmodial mode of action of 1 involves a chloroquine-like mode of action (inhibition of hemozoin formation) that is independent of interactions with DNA (Wright et al., 2001), suggesting the possibility that it may be possible to prepare analogues of 1 that do not intercalate into DNA bu...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4839679

Genes involved in cell adhesion featured prominently in our transcriptional dataset and overlapped with genes uniquely regulated by PBRM1 in clinical specimens of ccRCC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11394730

The results of a pilot investigation indicated that epicatechin, but not catechin, the two naturally occurring antioxidants in green tea, increased the anticancer activity of panaxadiol (PD), a purified ginseng component.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11775197

In HCT-116 cells, hypoxic stress induces transcriptional activation of PPARβ/δ.

[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "HCT-116", "cells", ",", "hypoxic", "stress", "induces", "transcriptional", "...

PMC9429973

The most common subsequent treatment regimens based on hierarchy were daratumumab (22.1% claims; 17.4% EHR), carfilzomib (10.6% claims; 18.4% EHR), and pomalidomide based (12.3% claims; 8.7% EHR).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11739504

In the early stages of primary cilia assembly, loss of Kat2b disrupts α-tubulin acetylation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "early", "stages", "of", "primary", "cilia", ...

PMC9688728

Methyl esters of 20 fatty acids were used as internal standards.

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PMC9512971

The primary efficacy endpoint was the time to the first two consecutive negative tests for SARS-CoV-2.

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PMC9429973

Pts were grouped based on sequence of therapy and response to frontline treatment for additional subgroup analysis.

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PMC10545062

The left external jugular vein was cannulated with a triple lumen catheter for mIVF, vasoactive medication administration, and central venous pressure (CVP) measurements.

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PMC10452486

LA45 antigens could not be detected on the surface and the cytoplasm of resting peripheral blood lymphocytes (PBLs) or bone marrow mononuclear and polymorphonuclear cells.

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PMC11604015

There are several ways to overcome fratricide, including artificial reduction of surface target antigens (gene-editing and ER and/or Golgi-retaining) and natural selection.

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PMC11732628

Micro RNA-490-3p (miR-490-3p) is associated with a variety of malignancies.

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PMC11680982

This implies a potential effect of HER2-low status on the response to CDK4/6 inhibitors in HR/HER2- breast cancer, possibly associated with resistance mechanisms.

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PMC11525028

NAT10, ATF4, and ASNS protein levels in 143B (left) and HOS (right) cells treated with paliperidone or AG-401 (24 h) at the indicated concentrations. (

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PMC9261184

To understand the GHG results in context, this study is compared to three recent desk-based studies, Roman-White et al., NETL, and thinkstep, as shown in Figure 4.

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PMC11684269

Among these, T cell metabolic modulation is widely discussed, and these outstanding achievements may shed light on the treatment of kidney diseases.

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PMC11754094

Determining the frequency of deletion events >100 bp is challenging using short-range high-throughput sequencing methods.

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PMC9429973

The case selection process is summarized in Figure 1.

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PMC11547972

The combined use of low-dosed amygdalin and SFN could, therefore, be beneficial as a complementary option to treat RCC.

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PMC11345828

Anhydrous MeCN (80 mL) was added and the solution was stirred at 80 °C overnight.

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PMC9429973

DA treatment was started at 100mg once daily after molecular relapse was confirmed, and continued for at least 12 months after achieving ≥ MR4 until DISC for TFR2.

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PMC3730428

FLIP is mainly expressed as two splice forms: a long form FLIP(L) and a short form FLIP(S).

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PMC11248911

The CHARMM-GUI solution builder includes five steps.

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PMC6600253

Mutations in the RAS oncogene are common in many human cancers.

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PMC9596868

Representative fluorescence microscopy images of A2780 cells treated with 2 μM MST-312 or 15 μM quercetin and their combination for 48 h. (F) Quantification of γ-H2AX foci positive cells in A2780 cells.

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PMC9429973

Aims: Investigate the ability of the CD20-targeted T-cell-engaging bispecific antibody glofitamab (CD20-TCB) to overcome T cell exhaustion and tumor microenvironment (TME)-mediated immunosuppression in CLL.

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PMC9960565

H-NMR (400 MHz, D2O) [ppm]: δ= 2.63 (Hc + Hi, t, 23H), 2.66 (Ha, s, 4H), 2.97 (Hg, t, 8H), 3.26 (Hb, t, 10H), 3.34 (Hh, t, 12H), and 3.64 (Hf, t, 8H).

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PMC11700247

These consistent findings were also observed in vivo (Figure 5E-F).

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PMC11012012

Our results showed that SLAMF3/CD229 is significantly upregulated in CLL in comparison with normal B cells .

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PMC9621239

The ratios of cells in the S phase among the Vector, WT, SM, DM and TM groups are presented on the right at the top of the panel in (A) or (B); Each symbol represents an individual experiment.

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PMC9429973

We found that the TUG and MNA-SF scores could stratify the risk of grade ≥ 3 AEs in the IMWG GA Int-fit group (P < 0.05).

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PMC11643491

To further translate the differences in uptake into biological effects in drug delivery, we adapted the heat-induced stretching method from PS to biodegradable, poly(lactic-co-glycolic acid) (PLGA) particles loaded with paclitaxel.

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PMC11532793

Results are averaged over 20 simulations.

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PMC11026382

It is possible that these mutations caused a growth rate defect through toxicity linked to DHFR mis-folding and aggregation, a mechanism not captured by our model.

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PMC11626627

TWIST1′s recognition as miR-204–3p's downstream target sheds light on ccRCC's molecular dynamics.

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PMC11641630

The MB49 cell line is extensively used to study the murine orthotopic model of the disease.

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PMC11750165

Although PEX1 morphants showed phenotypical similarity to Jagged2 morphants, the number of KA” neurons in PEX1 morphants was increased approximately 1.4±0.2-fold, and that in PEX1 deletion mutants was only increased approximately 1.2+0.01-fold.

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PMC11055323

h Venn plot shows the intersection of CTCF binding sites in BJ cells with the overexpression of SS18-SSX1 and SS18(YA)-SSX as control.

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PMC11451940

Subsequently, the cells were washed once with PBS (0.1 M, pH 7.4), and cell cycle analysis was conducted using the BD Cycletest™ Plus DNA kit (Becton Dickinson, USA) following the manufacturer's protocol.

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PMC11765678

The concentration of protein in the samples was determined using the PierceTM BCA Protein Assay (Thermo Fisher, 23225).

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PMC11429241

Nevertheless, the deviations were minuscule and had a minimal impact on the mechanical stability of the structures or shape fidelity, as evident from the SEM analysis (Figure 4b).

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PMC9917080

At the same time, the selenium-sorafenib nanocomplex was more pronounced and selectively activated the Ca signaling system of A-172 glioblastoma cells, compared to “naked” SeNPs, causing higher amplitude Ca responses.

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PMC11731161

Using Co-IP assay, we confirmed that USP7 possesses an endogenous interaction with XPO1 in NCI-H929 and MM.1S cells (Fig. 3E, F), while SEL substantially disrupts this interaction (Fig. 3G).

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PMC11680982

T47D cells were treated with 100 nM fulvestrant (MedChem Express, USA) and 150 nM palbociclib (MedChem Express, USA).

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PMC11658074

AT-EVs increased Col1A1 levels while decreasing MMP9 and CDKN1A levels in NIH3T3 cells, as confirmed by both qRT‒PCR and WB (Fig. 3b‒d).

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PMC11756514

The cell lines (200,000 cells) were incubated with 10 µg/mL biotin-conjugated neoglycoproteins (Fuc-BSA, Man-BSA, GlcNAc-BSA, GalNAc-BSA, Gal-BSA or BSA) in HBS+ for 30 min at room temperature.

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PMC11727907

The importance of the RPE in the retina is also related to its metabolic contribution to retinal function maintenance.

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PMC11718031

Monoclonal antibodies (mAbs) contribute to a large fraction of therapeutics on the market today (Ecker et al. 2015).

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PMC11615828

Although the evidence is indirect, MTs undergo different post‐translational modifications and have preferential affinities to different types of motor proteins that may act as railways for distinct transport pathways.

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PMC10631132

While the entire differentiation process can be divided into three major steps of mesodermal, hematopoietic and OC differentiation, each step can be further subdivided into steps that are recapitulated in ontogenesis.

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PMC8956657

B Sequence logo demonstrating conservation of positively charged amino acids (blue) within the NLS region of ORF4b from the merbecoviruses in panel A (see Supplementary Fig. 10 for the full multiple sequence alignment).

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PMC9611901

They were seeded in 25 cm flasks and maintained in a humidified atmosphere of 5% CO2 at 37 °C (Heraeus Hera Cell 240 incubator, Langenselbold, Germany).

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PMC10728535

COL4A6 is involved in ECM‐receptor interaction.

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PMC8414691

P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the mock group by Fisher’s exact test RNAi-mediated depletion of DOM-A affects mitosis and cytokinesis in Drosophila S2 cells.

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PMC5854676

θ is diffraction angle measured in radians.

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PMC10877303

According to the crystal structure of 3CL, each monomer remains perpendicular in the homodimer consisting of a core chymotrypsin-like fold assembled by two domains, designated domains I and II, consisting of residues 1–187, a prolonged connecting loop consisting of residues 188–204, and domain III or C-terminal alpha-h...

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PMC11657744

P < 0.05; **, P < 0.01; ***, P < 0.001. (

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PMC9429973

There is also no data comparing CPX-351 to FLAG-IDA which is used in our institution front line for high-risk AML Aims: The objective of our multi-centre study was to assess outcomes of CPX-351 and then compare these outcomes in patients who received FLAG-IDA and 3 + 7 for high risk AML(tAML and AML-MRC).

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PMC9429973

197 have undergone at least one treatment.

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PMC11629192

When the response to the first-line therapy is inadequate or when the disease is severe or relapsing, escalation of immunotherapy to the second-line immunotherapy is needed .

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PMC11317131

This activity is linked to the generation of gIII such that successful integrases capable of acting on their att sites enable propagation of infectious phage harboring their coding sequence.

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PMC10898159

GIST is inherently resistant to radiotherapy and cytotoxic drug , albeit some end-stage cases with GIST treated by radiotherapy can achieved palliative pain-relief [226–228].

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PMC10507284

In sum, these above results imply that the TROAP‐derived signature has a superior predictive capacity.

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PMC11674146

B, C) Relative CLP36 protein expression level in lymphoma cells calculated based on immunoblotting assay. (

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PMC11747467

Next, we established the hierarchical clustering dendrogram of the 1-TOM matrix to determine coexpression modules.

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PMC10958426

The genes located in duplication regions express significantly higher than the genes in noCNV regions (P = 4.9 × 10) and deletion regions (P = 4.9 × 10), with genes in deletion regions have the lowest expression levels (Fig. 2C).

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PMC10329237

LOS and PFD increase the activation of SOD and CAT while decreasing MDA content in A549-treated BLM.

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PMC8735881

Effects of CMI constructs on the surface expression of CD4, CCR5, and CXCR4 in transduced TZM-bl cells were detected by FACS analysis using a PE-conjugated anti-human CD4, CCR5, or CXCR4 antibody and judged by fluorescence intensity.

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PMC10850553

The incubation mixture was then subjected to a western blot analysis using mouse monoclonal anti-human C5a/C5a des-Arg antibody (clone 2952, #HM2079, Hycult Biotech).

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PMC11301242

Two cycles with circular paths represent the ecDNA structure. (

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PMC11448304

Our analysis revealed 920 significantly differentially expressed genes and 699 proteins.

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PMC8414691

Cit-K is the main abscission regulator capable of physically and functionally interacting with the actin-binding protein Anillin, a crucial component of the contractile ring and midbody .

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PMC11345828

Mixtures containing vehicle without compound served as a negative control, while mixtures containing no protein served as a positive control.

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PMC10850553

The tag count of each known factor mediating the migration of neutrophils like C5ar1 from two-independent data sets is shown.

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PMC9786247

Thereafter, the cells were washed with PBS and subsequently lysed with RLT buffer (RNeasy Mini Kit; Qiagen, Hilden, Germany).

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PMC11792766

HepG2 and Caco‐2 cells were seeded in 96‐well plates at a density of 25,000 cells per well in culture medium.

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PMC11078693

Otherwise, cap the tube, then shake and rotate it to position the cover glass correctly.

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PMC8009078

The ∆H is the term in which molecular mechanical energy (∆EMM) and solvation free energy (∆Esol) are involved.

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PMC11597291

The test was repeated thrice, and the percent of hemolysis was calculated from the following equation:(1)Hemolysis %=AnCGO−AnegativeApositive−Anegative×100 where AnCGO, Apositive, and Anegative are the absorbances of hemoglobin contained in the supernatant of the nCGO and nCGO-PEG particles, in the negative control and...

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PMC8358176

Relative mRNA levels of TNF family genes in the MWCNT- and SWCNT-exposed Jurkat cell line.

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PMC7868205

The IC50 value for the hydrosol against HEK-293 cells was 0.622 µL/mL (622 ppm).

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PMC8382973

The datasets presented in this study can be found in online repositories.

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PMC11701801

A, Volume of tumor xenografts derived from SMARCA4/SMARCA2-deficient DMS114 cell lines and harvested from mice treated once daily with 30 mg/kg CP-C27.

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