OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC6461034	Cut tumor tissue into small pieces, wash with PBS, and dissociate further using shear distress (pipetting).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cut", "tumor", "tissue", ...
PMC11568601	Fig. 4RNA-seq analysis of 143B cells treated with TGT for 24 h. A Volcano plot of DEGs with q-value < 0.05 and \|log2 FC\|>1 as threshold in the TGT 40 and 80 mg·mL group.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Finally, iron showed a profound impact on the stem cell pool in MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "iron", "showed", "a", "profound", "impact", "on"...
PMC11585587	These results suggest that RA can induce apoptosis in MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "RA", "can", "induce", "apoptosis", "in", "MM", "." ...
PMC10243817	Although the tissue remodeling patterns of CRS subtypes have been established (22, 25), the contribution and regulation of different TGF-β isoforms and their corresponding receptors in the tissue remodeling in CRS are still undetermined (22, 26, 27).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	In our gRNA co-transfection screen, the most broadly active CRISPR treatments included tat/rev/gp41-directed TatE. One implication that follows is that usage of TatE-directed CRISPR may help overcome low potency and viral escape otherwise associated with single gRNA treatment of HIV-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11641532	Data from GSE131685 provided transcriptomic profiles of 23,366 cells from three normal kidney samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "from", "GSE131685", "provided", "transcriptomic", "profiles", ...
PMC11740399	Lipo: liposome, Mem: tumor membranes, ML: cell membrane hybrid liposomes. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lipo", ":", "liposome", ",", "Mem", ":", "tumor"...
PMC10578720	However, it remains unknown if acetylation participates in HBV-induced macrophage M2-like polarization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "remains", "unknown", "if", "acetylation", "participat...
PMC11394730	By inducing the expression of the ATP-binding cassette transporter A1, LXRs improve the reverse transport of cholesterol from peripheral tissues (ABCA1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11228511	Percentage of nuclear blebs with an abnormal progerin meshwork in blebs with lamin B1 and blebs without lamin B1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentage", "of", "nuclear", "bl...
PMC9429973	Τhe incidence rate was 9.6% and 24.3% for vaccinated and unvaccinated patients, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Τhe", "incidence", "rate", "was", "9.6", "%", "a...
PMC9952933	ROS has a concentration-dependent influence on tumor cells and their environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROS", "has", "a", "concentration-dependent", "influence", "on", "tumor", "cells", "and", ...
PMC11775197	CRC has become the third leading cause of cancer deaths in people under 50 years of age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRC", "has", "become", "the", "third", "lea...
PMC11802929	We wrote a Snakemake workflow (https://github.com/racng/snakemake-merge-wgs) for processing GVCF files from WGS to generate a multi-sample VCF file of exon variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC9646302	Numerous pathways are involved in the progression of ccRCC, including MAPK, wingless/integrated, and PI3K/Akt pathways [28–30].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "pathways", ...
PMC7642379	Blue bars show number of DE genes in each pairwise comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blue", "bars", "show", "number", "of", "DE", "genes", "in", "each", "pairwise", ...
PMC11792090	A lower percentage of dual-fluorescent cells in the CD47 UCAR-T group indicated a reduced phagocytic rate of macrophages ( Figures 3F, G ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7519871	Gasteiger charges were added and were saved in pdbqt format.30 The ligands WDL and BA were sketched and energy minimized in Discovery Studio Visualizer and saved in PDB format.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	A change to another exogenous promoter, for example, the CAG promoter, might mitigate concerns related to detection sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "change", "to...
PMC8143558	For non-crop plant species, it is important that conservation should be borne in mind when the plants are used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "non-crop", "plant", ...
PMC11650848	Additionally, blood samples were analysed for serum folate, red blood cell (RBC) folate, serum B12 and plasma homocysteine in maternal and cord blood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10919056	Gap junction proteins (GJPs) are a class of channel proteins that are closely related to cell communication and tumor development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gap", "junct...
PMC11599565	Wells were incubated with primary antibodies (Table ST2) resuspended in 1% BSA in PBST at concentrations following the manufacturers’ recommendations at 4 °C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients were excluded if they had no detectable mutations at diagnosis, had a second alloHCT in the observed time or if MDS patients had <10% bone marrow blasts at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Cancer genome studies highlighted alterations within the nucleosome remodelling and deacetylation (NuRD) complex occur in over 20% of all cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer"...
PMC10812665	Notably, gene expression was hardly affected at non-cytotoxic concentrations; only MPP and Rot showed a small response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "gene", "expressio...
PMC11361748	PKCα regulates cell–cell adhesion in epidermal keratinocytes by phosphorylating desmoplakin, leading to detachment of keratin IFs and destabilization of desmosomes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PKCα", ...
PMC11190538	All data was expressed as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "was", "expressed", "as", "mean", "±", "SD", "." ] } ]
PMC10958426	Wilcoxon signed rank test were performed to examine whether the number of detected genes were significantly different between normal tissue and tumor tissue for endothelial cells and stromal cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	All authors have committed to upholding the principles of research ethics and inclusion as advocated by the Nature Portfolio journals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "authors", "have", ...
PMC11394730	FAs are esterified to phospholipids (PLs) in cancer cells to facilitate membrane lipid production and encourage cell division .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FAs", "are", "esterified", ...
PMC11397654	Cells treated with only the anticancer drugs, as well as complexes of the drugs and 35 or 40, did not cause surface CRT exposure, while cells treated with the complexes of 36 and the anticancer drugs showed significant CRT exposure on the cells, meaning that while the drugs themselves are not ICD-inducers, the complexe...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11724582	In breast cancer, CAFs require YAP to promote increased matrix rigidity, cancer cell invasion, and angiogenesis, which are related to the regulation of the expression of multiple cytoskeletal regulatory factors by YAP .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	In conclusion, the present work provided some hints on various biological mechanisms underlying the activity of TB and provided evidence that TB is a candidate for novel strategies in the fight against MPM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	On the other hand, the CTHRC1FAP subpopulation had decreased activity of the TGFβ and TNFa pathways, resembling the activity of the ADH1B CAFs (Fig. 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	Furthermore, CCK-8 assay, Annexin V-FITC/PI assay, Transwell chamber assay, Cell scratch assay assays were performed to explore the impact of circ_SMA4 on cell proliferation and apoptosis in GISTs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	The RT-PCR analysis used the following amplification program from table III.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RT-PCR", "analysis", "used", "the", "following", "amplification", "program", "from",...
PMC10849234	MPO is an enzyme that diversifies reactive oxygen species production and is contained only within the primary granule subtype .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MPO", "is", "an", "enzyme", ...
PMC9727330	Several studies also indicated the crosslink between elevated ASNS expression and asparaginase efficacy in treating certain solid tumors (Zhang et al., 2014; Lomelino et al., 2017; Jiang et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11725127	The cellular stability of KRAS is controlled by a balance between ubiquitination and deubiquitination19, 20, 21, 22.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cellular", "stability...
PMC10674574	We summarized the main aspects affecting the validation process of the Caco-2 cell line, including the culture conditions, cytotoxicity, cell differentiation process, and monolayer transport conditions, and the main conclusions may be useful in developing individual methods for preparing the cell line for validation pu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518994	b Dot plot of a PAX5 wild-type healthy donor compared with a PAX5 mutated carrier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Dot", "plot", "of", "a", "PAX5", "wild-type", "h...
PMC8409415	ADCs constitute a novel technology for targeting rapidly proliferating cells by combining monoclonal antibodies that are highly specific for tumor antigens with effective cytotoxic agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11470999	The tumor cells will grow and expand in the dish and they are collected as B16Br‐luc cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "tumor", "cells", "will", "grow", ...
PMC11806818	MCF-7 CTCsSYL3CMOF@Pt@MOFTMB/H2O2SWVColorimetryAu/rGO/ITO−5 − 5 × 10 cells/mL5 cells/mL100.0 − 109.0%(0.6 − 2.3%)− MCF-7 exosomesCD63EpCAMTMB-GQDzymesTMB/H2O2ColorimetryPhotothermal analysis−0 − 4 × 10 particles/µL2 × 10−4 × 10 particles/µL1027 particles/µL2170 particles/µL−− CD63MoS2- Au@PtTMB/H2O2ChronoamperometryCol...	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11665584	Cutaneous wound healing is a slow process that often terminates with permanent scarring while oral wounds, in contrast, regenerate after damage faster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11742231	The IC50 values of each drug–cell pair were normalized to a range between 0 and 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "values", "of", "each", ...
PMC11768281	This process underscores the importance of both positive and negative regulatory signals in shaping the immune response against malaria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "underscores", ...
PMC11754784	g Flow cytometry analysis-based fluorescence intensity statistics of five different cancer cells treated with cage-Nb, cage-Nb-sgc4f, cage-Nb-sgc8c, and DNP2 in Cy5 channel, TAMRA channel and FAM channel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We aimed to characterize a cellular model of homozygous and heterozygous CXCR4 in the endogenous locus, to better understand the pathogenic impact of harboring mutations in one or both alleles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	Gu et al. reported a co-delivery system of DOX and short hairpin RNA (shRNA) targeting MMP-9 enzyme comprised of graphene oxide (GO) functionalized with G3 PAMAM to ally the high drug loading capacity of GO with the efficient transfection ability of the polymer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Statistical significance is p <0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "is", "p", "<", "0.05", "." ] } ]
PMC11790971	Highly correlated features were identified prior to the PIMP measurement to avoid underestimating PIMP scores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Highly", "correlated", "features", "were", "identified", "prior",...
PMC7723249	Bars represent mean ±SD based on three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "represent", "mean", "±SD", "based", "on", "three", "independent", "experiments", "." ] } ]
PMC8992508	Homoverrucosanoid derivatives SAR studies revealed that specific structure, configuration and general lipophilicity of the homoverrucosane scaffold are important factors for effective molecular recognition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10831439	To generate monocyte-derived DCs (mo-DCs), plastic-adherent monocytes isolated from PBMCs were cultured for 6 days in RPMI 1640 GlutaMAX Medium (ThermoFisher Scientific), 10% FBS (Sigma-Aldrich), 100 I.U./mL penicillin-streptomycin (Lonza), 11.4 µM 2-mercaptoethanol (Roth, Karlsruhe, Germany), 0.1 mM non-essential amin...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584666	IL-1β levels in the samples were measured using the cytometric bead array-enhanced flex bead set by flow cytometry (FACSCanto II, BD Biosciences).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Overall response rate (ORR) was based on patients whose response ≥MR and clinical beneficial rate (CBR) was calculated in patients completed at least 3 cycles and reached ≥SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	To induce corneal epithelial transdifferentiation, we recapitulated the microenvironment of the corneal limbus in vitro by utilizing conditioned media from LNCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "induce...
PMC11676674	Table 1 shows in better detail the main characteristics of each numbered peak (retention time, putative annotation, experimental m/z, molecular formula, main adduct in negative and positive acquisition modes, mass error in negative mode, and the fragments observed in ms/ms).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11486946	The Kullback–Leibler divergence (KLD) was used to quantify the similarity of the histogram profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Kullback", "–", "Leibler", "div...
PMC11026382	d Comparison of the relative growth rate effects for DHFR single mutants in the WT and TYMS R166Q backgrounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Comparison", "of", "the", ...
PMC11700523	In vitro experiments involved transfecting COS-7 cells with MR expression plasmids and MR response element-luciferase reporter plasmids.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", "experiments", "involved", ...
PMC9429973	After a 43-month median follow-up, none of the patients died, and 15 patients experienced reactivation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "43-month", "median", "follow-up", ...
PMC11678130	Moreover, for the combinatorial treatment, QUE at the concentration of 10 μM was associated with 5-FU, considering that it is a high, but physiologically achievable, concentration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	Nevertheless, because of BiP’s pervasive effects on ER proteostasis and its role in direct repression of the IRE1 branch, its role in regulating ATF6 might have been missed by this screen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	Cell lines were maintained in the logarithmic phase at 37 °C in a 5 % carbon dioxide atmosphere using the following culture media containing 10 % fetal calf serum (EuroClone, Milan, Italy), antibiotics (50 units/mL penicillin and 50 μg/mL streptomycin) and 2 mM l‐glutamine: (i) RPMI‐1640 medium (EuroClone) for A431, A4...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11484188	miR-1343-3p is downregulated in cancer tissue, including pancreatic, prostate and colon cancer (7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "miR-1343", "-", "3p", "is", ...
PMC11707577	Finally, switching from in vitro biosystems to in vivo whole animal system, M13EGFR(TNP) was tested in a tissue‐like organism, Hydra vulgaris, recognized as unique model to test biosafety and bioactivity of a multitude of nanostructured devices.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	Effective overexpression of circZDHHC11 was confirmed by RT-qPCR with a fold induction of about 500 in ST486 and 45 in DG75, respectively (Fig. 3A,D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	39 patients were reviewed at a mean of 12.7±3.6 months following recovery from SARS-CoV-2 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "39", "patients", "were", "reviewed", "at", "a", "mean", ...
PMC11531735	Negative Control; 7.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Negative", "Control", ";", "7", "." ] } ]
PMC9504875	TRIM25 was also targeted by several viral proteins including NS1 of IAV , E6 oncoprotein of human papillomavirus , NSs of Dabie bandavirus , and the small T antigen (tAg) of polyomaviruses, such as JC virus and BK virus .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mean age was 71,2 years(61-87).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "age", "was", "71,2", "years(61", "-", "87", ")", "." ] } ]
PMC11055510	Equal amounts of denatured proteins (30 µg) were subjected to 10 % sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "amounts", "of", "denatur...
PMC11767817	The concept of cancer hallmarks highlights the features/properties of cancer cells that account for the cellular and molecular mechanisms responsible for developing and acquiring abnormal phenotypic capabilities during the initiation and progression of cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661040	5 × 10 adherent cells were digested and collected, washed and centrifuged with PBS, and 1 mL of 75% ethanol was added to the cell precipitation and fixed at 4℃ for 1 h. After fixation, the cells were washed with PBS, and the working solution (containing RNaseA reagent and PI dye solution) was dyed according to the reag...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Klebsiella pneumoniae had the highest resistance rate (100%) to ampicillin, and the highest susceptibility rate (0) to tigecycline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11420784	Data are representative of 3 independent experiments and presented as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "representative", "of", "3", "independent", "experiments...
PMC9429973	Together, these data implicate TLR9 signalling as a tumour escape mechanism following BTKi therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", "data", "implicate", "TLR9", "sign...
PMC11513571	Epithelial cells are known to generate various inflammatory mediators, such as a wide spectrum of cytokines and chemokines, which induce T helper 1 (Th1) proinflammatory cells or T helper 2 (Th2) anti-inflammatory cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11021472	Membranes were blocked in 5% ELK in TBST, followed by incubation with antibodies diluted in 5% ELK in TBST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membranes", ...
PMC9429973	One pt in the PBO arm discontinued the study before being dosed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "pt", "in", "the", "PBO", "arm", "discontinued", "the", "study", "be...
PMC11001582	n = 5 mice per genotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", "mice", "per", "genotype", "." ] } ]
PMC8382973	When formulated into a gel, 2P23 was stably released, maintained, and blocked HIV infection in vitro, independent of temperature (25°C–60°C), pH (4.0–8.0), and H2O2 concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	10% FBS, 1 mM L-glutamine solution, streptomycin and penicillin, and 0.2% sodium bicarbonate were added to a DME-supplemented medium with a pH of 7.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8996378	The main skeleton types of diterpenoids include, among others, kaurenes, clerodanes, abietanes and labdanes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "skeleton", "types", "of...
PMC11766174	Currently, several approaches to quantify markers of the HIV reservoir exist, including those that measure the proviral DNA by PCR, the intact proviral DNA by digital PCR (IPDA), the HIV viral RNA by qPCR, the HIV capsid protein (CA) by digital single-molecule assay (Simoa), and the amount of replication-competent viru...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	In preliminary experiments we determined amplitude of voltage/electric field at which high membrane permeabilization and cell survival at the same time is achieved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC9429973	Plates were analysed using the IRIS reader providing both spot-forming unit (SFU) frequency and relative spot volume (RSV).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "we...
PMC10719213	Uniquely aligned reads (samtools view -q 1) were converted to bam format, sorted and indexed with samtools .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Uniquely", "aligned", "reads...
PMC9966931	H NMR (600 MHz, CDCl3) δ 8.24 (dd, J = 7.4, 1.3 Hz, 2H), 7.67–7.63 (m, 1H), 7.53 (dd, J = 8.3, 7.6 Hz, 2H), 7.23–7.17 (m, 1H), 7.10 (dd, J = 7.8, 1.8 Hz, 1H), 7.01 (d, J = 1.8 Hz, 1H), 2.92 (hept, J = 6.9 Hz, 1H), 2.22 (s, 3H), 1.26 (d, J = 6.9 Hz, 6H). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: In this contemporary population-based study, concurrent RS patients have superior OS, while survival among treated RS patients is very poor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11310713	The injectable artificial ovary for HRT introduces a novel, non-invasive method for cell-based HRT, with potential for adaptation across a variety of cell-based treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Firstly, we extracted the brain registering the MNI152 on the T1 image.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "we", "extracted", "the", "brain", "registering", "the", ...
PMC11521786	No visible adverse effects or signs of toxicity were observed in the behavior, weight, or histology of the analyzed organs, indicating the safety of the HER3-based vaccine candidate (see Supplementary Figure S4 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9268183	In addition, an original publication search was carried out using four major online databases for scientific bibliographic resources, namely PubMed, ScienceDirect, Scopus and Web of Science, using the following set of keywords: “scientific name” AND “cancer” AND “chemical compounds”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	The ζ-potential recorded was −7.5 mV. The particle concentration measured for Pt(Taxol)(OH) was 1 × 10 particles/mL. Determination of drug encapsulation was performed by HPLC using a calibration curve through gradient concentrations of the Pt(IV) compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	For example, cis-[PtCl2(5Braza)2] exhibited IC50 = 1.8, 2.0 and 0.6 μM against A2780, HOS osteosarcoma, and G-361 malignant melanoma, respectively (IC50 = 12.0, 34.2, and 3.4 μM, respectively, for CDDP) [28–29].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O"...

PMC6461034

Cut tumor tissue into small pieces, wash with PBS, and dissociate further using shear distress (pipetting).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cut", "tumor", "tissue", ...

PMC11568601

Fig. 4RNA-seq analysis of 143B cells treated with TGT for 24 h. A Volcano plot of DEGs with q-value < 0.05 and |log2 FC|>1 as threshold in the TGT 40 and 80 mg·mL group.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Finally, iron showed a profound impact on the stem cell pool in MDS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "iron", "showed", "a", "profound", "impact", "on"...

PMC11585587

These results suggest that RA can induce apoptosis in MM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "RA", "can", "induce", "apoptosis", "in", "MM", "." ...

PMC10243817

Although the tissue remodeling patterns of CRS subtypes have been established (22, 25), the contribution and regulation of different TGF-β isoforms and their corresponding receptors in the tissue remodeling in CRS are still undetermined (22, 26, 27).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8633974

In our gRNA co-transfection screen, the most broadly active CRISPR treatments included tat/rev/gp41-directed TatE. One implication that follows is that usage of TatE-directed CRISPR may help overcome low potency and viral escape otherwise associated with single gRNA treatment of HIV-1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11641532

Data from GSE131685 provided transcriptomic profiles of 23,366 cells from three normal kidney samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "from", "GSE131685", "provided", "transcriptomic", "profiles", ...

PMC11740399

Lipo: liposome, Mem: tumor membranes, ML: cell membrane hybrid liposomes. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lipo", ":", "liposome", ",", "Mem", ":", "tumor"...

PMC10578720

However, it remains unknown if acetylation participates in HBV-induced macrophage M2-like polarization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "remains", "unknown", "if", "acetylation", "participat...

PMC11394730

By inducing the expression of the ATP-binding cassette transporter A1, LXRs improve the reverse transport of cholesterol from peripheral tissues (ABCA1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11228511

Percentage of nuclear blebs with an abnormal progerin meshwork in blebs with lamin B1 and blebs without lamin B1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentage", "of", "nuclear", "bl...

PMC9429973

Τhe incidence rate was 9.6% and 24.3% for vaccinated and unvaccinated patients, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Τhe", "incidence", "rate", "was", "9.6", "%", "a...

PMC9952933

ROS has a concentration-dependent influence on tumor cells and their environment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROS", "has", "a", "concentration-dependent", "influence", "on", "tumor", "cells", "and", ...

PMC11775197

CRC has become the third leading cause of cancer deaths in people under 50 years of age.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRC", "has", "become", "the", "third", "lea...

PMC11802929

We wrote a Snakemake workflow (https://github.com/racng/snakemake-merge-wgs) for processing GVCF files from WGS to generate a multi-sample VCF file of exon variants.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...

PMC9646302

Numerous pathways are involved in the progression of ccRCC, including MAPK, wingless/integrated, and PI3K/Akt pathways [28–30].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "pathways", ...

PMC7642379

Blue bars show number of DE genes in each pairwise comparison.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blue", "bars", "show", "number", "of", "DE", "genes", "in", "each", "pairwise", ...

PMC11792090

A lower percentage of dual-fluorescent cells in the CD47 UCAR-T group indicated a reduced phagocytic rate of macrophages ( Figures 3F, G ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC7519871

Gasteiger charges were added and were saved in pdbqt format.30 The ligands WDL and BA were sketched and energy minimized in Discovery Studio Visualizer and saved in PDB format.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11411131

A change to another exogenous promoter, for example, the CAG promoter, might mitigate concerns related to detection sensitivity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "change", "to...

PMC8143558

For non-crop plant species, it is important that conservation should be borne in mind when the plants are used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "non-crop", "plant", ...

PMC11650848

Additionally, blood samples were analysed for serum folate, red blood cell (RBC) folate, serum B12 and plasma homocysteine in maternal and cord blood.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10919056

Gap junction proteins (GJPs) are a class of channel proteins that are closely related to cell communication and tumor development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gap", "junct...

PMC11599565

Wells were incubated with primary antibodies (Table ST2) resuspended in 1% BSA in PBST at concentrations following the manufacturers’ recommendations at 4 °C overnight.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Patients were excluded if they had no detectable mutations at diagnosis, had a second alloHCT in the observed time or if MDS patients had <10% bone marrow blasts at diagnosis.

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PMC9429973

Cancer genome studies highlighted alterations within the nucleosome remodelling and deacetylation (NuRD) complex occur in over 20% of all cancers.

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PMC10812665

Notably, gene expression was hardly affected at non-cytotoxic concentrations; only MPP and Rot showed a small response.

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PMC11361748

PKCα regulates cell–cell adhesion in epidermal keratinocytes by phosphorylating desmoplakin, leading to detachment of keratin IFs and destabilization of desmosomes .

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PMC11190538

All data was expressed as mean ± SD.

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PMC10958426

Wilcoxon signed rank test were performed to examine whether the number of detected genes were significantly different between normal tissue and tumor tissue for endothelial cells and stromal cells. (

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PMC11607321

All authors have committed to upholding the principles of research ethics and inclusion as advocated by the Nature Portfolio journals.

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PMC11394730

FAs are esterified to phospholipids (PLs) in cancer cells to facilitate membrane lipid production and encourage cell division .

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PMC11397654

Cells treated with only the anticancer drugs, as well as complexes of the drugs and 35 or 40, did not cause surface CRT exposure, while cells treated with the complexes of 36 and the anticancer drugs showed significant CRT exposure on the cells, meaning that while the drugs themselves are not ICD-inducers, the complexe...

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PMC11724582

In breast cancer, CAFs require YAP to promote increased matrix rigidity, cancer cell invasion, and angiogenesis, which are related to the regulation of the expression of multiple cytoskeletal regulatory factors by YAP .

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PMC11218145

In conclusion, the present work provided some hints on various biological mechanisms underlying the activity of TB and provided evidence that TB is a candidate for novel strategies in the fight against MPM.

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PMC10582049

On the other hand, the CTHRC1FAP subpopulation had decreased activity of the TGFβ and TNFa pathways, resembling the activity of the ADH1B CAFs (Fig. 3D).

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PMC11422497

Furthermore, CCK-8 assay, Annexin V-FITC/PI assay, Transwell chamber assay, Cell scratch assay assays were performed to explore the impact of circ_SMA4 on cell proliferation and apoptosis in GISTs.

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PMC11534377

The RT-PCR analysis used the following amplification program from table III.

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PMC10849234

MPO is an enzyme that diversifies reactive oxygen species production and is contained only within the primary granule subtype .

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PMC9727330

Several studies also indicated the crosslink between elevated ASNS expression and asparaginase efficacy in treating certain solid tumors (Zhang et al., 2014; Lomelino et al., 2017; Jiang et al., 2021).

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PMC11725127

The cellular stability of KRAS is controlled by a balance between ubiquitination and deubiquitination19, 20, 21, 22.

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PMC10674574

We summarized the main aspects affecting the validation process of the Caco-2 cell line, including the culture conditions, cytotoxicity, cell differentiation process, and monolayer transport conditions, and the main conclusions may be useful in developing individual methods for preparing the cell line for validation pu...

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PMC11518994

b Dot plot of a PAX5 wild-type healthy donor compared with a PAX5 mutated carrier.

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PMC8409415

ADCs constitute a novel technology for targeting rapidly proliferating cells by combining monoclonal antibodies that are highly specific for tumor antigens with effective cytotoxic agents.

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PMC11470999

The tumor cells will grow and expand in the dish and they are collected as B16Br‐luc cells.

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PMC11806818

MCF-7 CTCsSYL3CMOF@Pt@MOFTMB/H2O2SWVColorimetryAu/rGO/ITO−5 − 5 × 10 cells/mL5 cells/mL100.0 − 109.0%(0.6 − 2.3%)− MCF-7 exosomesCD63EpCAMTMB-GQDzymesTMB/H2O2ColorimetryPhotothermal analysis−0 − 4 × 10 particles/µL2 × 10−4 × 10 particles/µL1027 particles/µL2170 particles/µL−− CD63MoS2- Au@PtTMB/H2O2ChronoamperometryCol...

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PMC11665584

Cutaneous wound healing is a slow process that often terminates with permanent scarring while oral wounds, in contrast, regenerate after damage faster.

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PMC11742231

The IC50 values of each drug–cell pair were normalized to a range between 0 and 1.

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PMC11768281

This process underscores the importance of both positive and negative regulatory signals in shaping the immune response against malaria.

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PMC11754784

g Flow cytometry analysis-based fluorescence intensity statistics of five different cancer cells treated with cage-Nb, cage-Nb-sgc4f, cage-Nb-sgc8c, and DNP2 in Cy5 channel, TAMRA channel and FAM channel.

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PMC9429973

We aimed to characterize a cellular model of homozygous and heterozygous CXCR4 in the endogenous locus, to better understand the pathogenic impact of harboring mutations in one or both alleles.

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PMC5600151

Gu et al. reported a co-delivery system of DOX and short hairpin RNA (shRNA) targeting MMP-9 enzyme comprised of graphene oxide (GO) functionalized with G3 PAMAM to ally the high drug loading capacity of GO with the efficient transfection ability of the polymer .

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PMC9429973

Statistical significance is p <0.05.

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PMC11790971

Highly correlated features were identified prior to the PIMP measurement to avoid underestimating PIMP scores.

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PMC7723249

Bars represent mean ±SD based on three independent experiments.

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PMC8992508

Homoverrucosanoid derivatives SAR studies revealed that specific structure, configuration and general lipophilicity of the homoverrucosane scaffold are important factors for effective molecular recognition.

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PMC10831439

To generate monocyte-derived DCs (mo-DCs), plastic-adherent monocytes isolated from PBMCs were cultured for 6 days in RPMI 1640 GlutaMAX Medium (ThermoFisher Scientific), 10% FBS (Sigma-Aldrich), 100 I.U./mL penicillin-streptomycin (Lonza), 11.4 µM 2-mercaptoethanol (Roth, Karlsruhe, Germany), 0.1 mM non-essential amin...

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PMC8584666

IL-1β levels in the samples were measured using the cytometric bead array-enhanced flex bead set by flow cytometry (FACSCanto II, BD Biosciences).

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PMC9429973

Overall response rate (ORR) was based on patients whose response ≥MR and clinical beneficial rate (CBR) was calculated in patients completed at least 3 cycles and reached ≥SD.

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PMC11721064

To induce corneal epithelial transdifferentiation, we recapitulated the microenvironment of the corneal limbus in vitro by utilizing conditioned media from LNCs.

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PMC11676674

Table 1 shows in better detail the main characteristics of each numbered peak (retention time, putative annotation, experimental m/z, molecular formula, main adduct in negative and positive acquisition modes, mass error in negative mode, and the fragments observed in ms/ms).

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PMC11486946

The Kullback–Leibler divergence (KLD) was used to quantify the similarity of the histogram profiles.

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PMC11026382

d Comparison of the relative growth rate effects for DHFR single mutants in the WT and TYMS R166Q backgrounds.

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PMC11700523

In vitro experiments involved transfecting COS-7 cells with MR expression plasmids and MR response element-luciferase reporter plasmids.

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PMC9429973

After a 43-month median follow-up, none of the patients died, and 15 patients experienced reactivation.

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PMC11678130

Moreover, for the combinatorial treatment, QUE at the concentration of 10 μM was associated with 5-FU, considering that it is a high, but physiologically achievable, concentration .

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PMC11286266

Nevertheless, because of BiP’s pervasive effects on ER proteostasis and its role in direct repression of the IRE1 branch, its role in regulating ATF6 might have been missed by this screen.

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PMC10092581

Cell lines were maintained in the logarithmic phase at 37 °C in a 5 % carbon dioxide atmosphere using the following culture media containing 10 % fetal calf serum (EuroClone, Milan, Italy), antibiotics (50 units/mL penicillin and 50 μg/mL streptomycin) and 2 mM l‐glutamine: (i) RPMI‐1640 medium (EuroClone) for A431, A4...

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PMC11484188

miR-1343-3p is downregulated in cancer tissue, including pancreatic, prostate and colon cancer (7).

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PMC11707577

Finally, switching from in vitro biosystems to in vivo whole animal system, M13EGFR(TNP) was tested in a tissue‐like organism, Hydra vulgaris, recognized as unique model to test biosafety and bioactivity of a multitude of nanostructured devices.

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PMC11021472

Effective overexpression of circZDHHC11 was confirmed by RT-qPCR with a fold induction of about 500 in ST486 and 45 in DG75, respectively (Fig. 3A,D).

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PMC9429973

39 patients were reviewed at a mean of 12.7±3.6 months following recovery from SARS-CoV-2 infection.

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PMC11531735

Negative Control; 7.

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PMC9504875

TRIM25 was also targeted by several viral proteins including NS1 of IAV , E6 oncoprotein of human papillomavirus , NSs of Dabie bandavirus , and the small T antigen (tAg) of polyomaviruses, such as JC virus and BK virus .

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PMC9429973

Mean age was 71,2 years(61-87).

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PMC11055510

Equal amounts of denatured proteins (30 µg) were subjected to 10 % sodium dodecyl sulfate-polyacrylamide gel electrophoresis.

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PMC11767817

The concept of cancer hallmarks highlights the features/properties of cancer cells that account for the cellular and molecular mechanisms responsible for developing and acquiring abnormal phenotypic capabilities during the initiation and progression of cancer .

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PMC11661040

5 × 10 adherent cells were digested and collected, washed and centrifuged with PBS, and 1 mL of 75% ethanol was added to the cell precipitation and fixed at 4℃ for 1 h. After fixation, the cells were washed with PBS, and the working solution (containing RNaseA reagent and PI dye solution) was dyed according to the reag...

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PMC9429973

Klebsiella pneumoniae had the highest resistance rate (100%) to ampicillin, and the highest susceptibility rate (0) to tigecycline.

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PMC11420784

Data are representative of 3 independent experiments and presented as the mean ± SD.

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PMC9429973

Together, these data implicate TLR9 signalling as a tumour escape mechanism following BTKi therapy.

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PMC11513571

Epithelial cells are known to generate various inflammatory mediators, such as a wide spectrum of cytokines and chemokines, which induce T helper 1 (Th1) proinflammatory cells or T helper 2 (Th2) anti-inflammatory cells.

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PMC11021472

Membranes were blocked in 5% ELK in TBST, followed by incubation with antibodies diluted in 5% ELK in TBST.

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PMC9429973

One pt in the PBO arm discontinued the study before being dosed.

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PMC11001582

n = 5 mice per genotype.

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PMC8382973

When formulated into a gel, 2P23 was stably released, maintained, and blocked HIV infection in vitro, independent of temperature (25°C–60°C), pH (4.0–8.0), and H2O2 concentration.

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PMC11680562

10% FBS, 1 mM L-glutamine solution, streptomycin and penicillin, and 0.2% sodium bicarbonate were added to a DME-supplemented medium with a pH of 7.4.

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PMC8996378

The main skeleton types of diterpenoids include, among others, kaurenes, clerodanes, abietanes and labdanes.

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PMC11766174

Currently, several approaches to quantify markers of the HIV reservoir exist, including those that measure the proviral DNA by PCR, the intact proviral DNA by digital PCR (IPDA), the HIV viral RNA by qPCR, the HIV capsid protein (CA) by digital single-molecule assay (Simoa), and the amount of replication-competent viru...

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PMC7305184

In preliminary experiments we determined amplitude of voltage/electric field at which high membrane permeabilization and cell survival at the same time is achieved.

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PMC9429973

Plates were analysed using the IRIS reader providing both spot-forming unit (SFU) frequency and relative spot volume (RSV).

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PMC10719213

Uniquely aligned reads (samtools view -q 1) were converted to bam format, sorted and indexed with samtools .

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PMC9966931

H NMR (600 MHz, CDCl3) δ 8.24 (dd, J = 7.4, 1.3 Hz, 2H), 7.67–7.63 (m, 1H), 7.53 (dd, J = 8.3, 7.6 Hz, 2H), 7.23–7.17 (m, 1H), 7.10 (dd, J = 7.8, 1.8 Hz, 1H), 7.01 (d, J = 1.8 Hz, 1H), 2.92 (hept, J = 6.9 Hz, 1H), 2.22 (s, 3H), 1.26 (d, J = 6.9 Hz, 6H). (

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PMC9429973

Image: Summary/Conclusion: In this contemporary population-based study, concurrent RS patients have superior OS, while survival among treated RS patients is very poor.

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PMC11310713

The injectable artificial ovary for HRT introduces a novel, non-invasive method for cell-based HRT, with potential for adaptation across a variety of cell-based treatments.

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PMC9429973

Firstly, we extracted the brain registering the MNI152 on the T1 image.

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PMC11521786

No visible adverse effects or signs of toxicity were observed in the behavior, weight, or histology of the analyzed organs, indicating the safety of the HER3-based vaccine candidate (see Supplementary Figure S4 ).

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PMC9268183

In addition, an original publication search was carried out using four major online databases for scientific bibliographic resources, namely PubMed, ScienceDirect, Scopus and Web of Science, using the following set of keywords: “scientific name” AND “cancer” AND “chemical compounds”.

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PMC11770746

The ζ-potential recorded was −7.5 mV. The particle concentration measured for Pt(Taxol)(OH) was 1 × 10 particles/mL. Determination of drug encapsulation was performed by HPLC using a calibration curve through gradient concentrations of the Pt(IV) compound.

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PMC4659567

For example, cis-[PtCl2(5Braza)2] exhibited IC50 = 1.8, 2.0 and 0.6 μM against A2780, HOS osteosarcoma, and G-361 malignant melanoma, respectively (IC50 = 12.0, 34.2, and 3.4 μM, respectively, for CDDP) [28–29].

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