OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11697065	It is therefore not surprising that the dominant signature across all antibody-expressing clones, independent of secretion profiles, was time-point of cell collection especially given the fact that cell culture parameters such as feeding were implemented from day 3 of culture onward, further distinguishing D0 and D6 ti...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467964	Furthermore, GO enrichment was performed, and the results demonstrated that DEBM cluster‐related genes were enriched in various important biological processes, such as the muscular process, extracellular matrix organization, extracellular structure organization, and muscle contraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Statistical analysis was performed using ordinary one‐way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "using", "ordinary", "one‐way", "ANOVA", "." ] } ]
PMC9429973	Eleven patients (64.7%) received at least two doses of mRNA-based vaccines and six (35.3%) were fully vaccinated with vector-based vaccines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10891340	However, the antiviral effect of CCCP in DEFs has not been clarified yet.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "antiviral", "effect", "of", "CCCP", "in",...
PMC8978939	Immunoprecipitation of GFP Trap showed a specific band of 25 kD for GFP alone and 50 kD on cells expressing GFP-pVHL-Venus Tag ( Figure 2A ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Patients with post-sternum diagnosis of hypo-MDS showed a significantly difference in five-year survival compared with patients with post-sternum diagnosis of AA (98.6% vs 86.1%, p=0.005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	1 × 10 cells/well in 6-well plates were treated for 48 h, fixed with 66% ethanol/4C/2 h, and stored at 4C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11680049	The fungicidal activity of plant extracts was determined by the growth of fungal mycelium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fungicidal", "activity", "of", "plant", "extracts", "was", ...
PMC11786704	The micrographs of capsules were obtained with confocal laser scanning microscopy (CLSM, Nikon A1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "micrographs", "of", "capsules", "were", ...
PMC11298021	Two groups were transfected with each mimic using TurboFect for 48 hours at a concentration of 50 nM. To investigate the impact of rapamycin on the cells, one group was subjected to rapamycin treatment alone at its IC50 concentration, another two groups received the same treatment procedure while being transfected with...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Swaminathan et al. developed bioprinted construct using pre-formed spheroids of human breast epithelial cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Swaminathan", "et", "al.", "developed", "bioprinted", "construct"...
PMC10907726	Scale bar: 10 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "10", "μm", ".", "(" ] } ]
PMC10976516	The latter implies a further necessity to improve the use of cell-mediated OV therapy for optimal clinical applications against lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "latter", "...
PMC11188874	Cells were transfected with the indicated sgRNA, incubated for 72 hours and then treated with each HDAC6 inhibitor (1 µmol/L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC11574271	In contrast, liver metastases were observed in both the J82-NC and J82-RON cell-injected mice, with the extent of hepatic damage being significantly greater in the J82-RON group compared to the J82-NC group (Fig. 7E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11515150	The efficacy of adoptive transfer of CD5 CAR-NK cells warrants further efforts to clinical application for patients with T-cell hematologic malignancies in a clinical trial setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10818062	Second, PI levels increased upon PS inhibition via acceleration of the PI cycle by Nir2/3-mediated PI/PA exchange.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ",", "PI", "levels", "increas...
PMC7582629	The loading vectors can make an orthonormal coordinate system able to reproduce both the total variable variance with all components and to reproduce the correlations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11766350	Cells transfected with the anti-gfp shRNA plasmid showed significantly higher viability compared to the scrambled shRNA control (76.8% vs. 59.8% respectively, Figure 2a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	Slides were H&E stained and QuPath Bioimaging Analysis software performed for nucleus to cell ratio to identify polyploidy cells (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Slides", "we...
PMC11747467	To further assess the relationship between RC48 and molecular subtypes, we first conducted a differential expression analysis comparing MIBC tissue to adjacent normal tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11791264	Each bar represents the mean ± SD (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "bar", "represents", "the", "mean", "±", "SD", "(", "n", "=", ...
PMC8873393	D The average relative transcript levels within each cluster presented in Fig. 5B are shown, with the log2 expression values on the y axis and time on the x axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	The following publicly available dataset was used: Skin Cutaneous Melanoma (TCGA, PanCancer Atlas). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "publicly", "available", ...
PMC9370419	The RNA-seq results revealed that CUL4-DDB1-related downstream genes were reduced after being treated with estradiol benzoate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RNA-seq", "results", "revealed", "that", "CUL4-...
PMC11266100	After the EP treatment the cells were transferred into a flat-bottom 96-well plate, incubated for 10 min and growth media to the final 200 μL volume in each well was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	For simplicity, from here onwards, phenylethyl-D-rutinoside, 8-geranylapigenin, Morusin, Kaempferol and Sanggenol L can be known as A1, A2, A3, A4 and A5, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	The cell culture, plasmid transfection and imaged for fluorescence as mentioned in the section “BiFC Assay”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "culture", ",", ...
PMC9812014	HCV affects about 3% of the world's populace and is the leading cause of chronic liver disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCV", "affects", "about", "3", ...
PMC9429973	OS and PFS rate at 1 year after infusion in GI bleeding group were significantly lower than those in non-bleeding group (OS 27.3% vs 57% (P = 0.0198), PFS 27.3% vs 60.9% (P = 0.0293)).3 cases(3/26,11.5%) died of GI bleeding and 10 cases (10/26,38.4%) died of disease progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	K. L. Chai, C. Wellard, N. Aoki, E. M. Moore, B. Augustson, A. Bapat, H. A. Blacklock, W. J. Chng, R. Cooke, C. Forsyth, N. Hamad, S. J. Harrison, P. J. Ho, J. Hocking, I. H. Kerridge, J. S. Kim, K. Kim, T. King, G. J. McCaughan, P. Mollee, C. O. Morrissey, N. Murphy, H. Quach, X. N. Tan, A. Tso, K. Wong, A. Spencer, E...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	Similarly, the BNC tumors exhibited concurrent activation of MAPK and PI3K pathways and cell lines derived from these tumors were sensitive to PI3K inhibitor BEZ-235 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	RT-qPCR was performed using TB Green Fast qPCR Mix (RR430, Takara, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-qPCR", "was", "performed", "using", "TB", "Green", ...
PMC11711345	However, in the BOILED-Egg (Brain Or Intestinal EstimateD) model, all the compounds had high GI absorption and BBB permeability values (Figure S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median age was 63 (range 19–79) years, and most patients had an International Prognostic Index of 3–5 (61.9%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11225860	The reduction of polyploidy in the combination therapy was seen during both the three- and five-day time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reduction", "of", "polyploidy", ...
PMC11513011	In keeping with the literature, this study also focuses on caspase-3 as a pivotal factor in bladder cancer apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "keeping", "with", ...
PMC11190238	b Pie chart depicting the distribution of dynamic (gray) and stable (black) compartments across the cell lines at both epithelial and mesenchymal compartments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	DMF has also been reported to suppress cell proliferation in multiple breast cancer cell lines via inhibition of NFκB activity (22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DMF", ...
PMC11719944	In Figure 7, the scatter plots illustrate the relationship between serum PRL levels and diagnosis time of T1D.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Figure", "7", ",", "t...
PMC9611901	Testing strategies often are complex; they should be performed in some logical sequence, and usually start with the in vitro assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Testing...
PMC6803987	Semi-preparative HPLC was carried out on an Agilent 1260 liquid chromatography (LC) with a Zorbax SB-C18 column (5 μM, 9.4 mm × 250 mm) (Agilent, Santa Clara, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	We isolated NLF-2522 from normal lung tissue of control mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "isolated", "NLF-2522", "from", "normal", "lung", "tissue", "of", "control", "mice", ...
PMC11052306	Since the discovery of cisplatin in the 1960s and the success of its use to treat cancers , researchers in bioinorganic chemistry have first focused on platinum derivatives, which are of current use to treat testicular, ovarian, and lung cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	Silencing circ_SMA4 partially inhibited GISTs malignant progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Silencing", "circ_SMA4", "partially", "inhibited", "GISTs", "malignant", "progression", "." ] } ]
PMC8777939	To test whether etravirine can suppress angiogenesis in ovarian cancer, we observed HUVEC tube formation under media conditions with etravirine at the indicated concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8956657	The MERS-CoV ORF4b protein is a viral accessory protein that functions as an innate immune inhibitor (Fig. 1A) and strongly localizes to the nucleus, despite virus replication occurring exclusively within the cytoplasmic compartment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Endocytosis was calculated as a decrease in cell surface receptors in agonist-treated cells compared with vehicle-treated cells after background subtraction from cells not transfected with the receptor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: There were 26 patients included in this study, with a median age of 41 years and of which 58% (n=15) were female.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	Indeed, OVCAR-8 cells, which are genetically less representative of HGSOCs than KURAMOCHI cells , are more tumorigenic , migrate faster (and Figure 1D), are more proliferative (and Figure 1B), and display more advanced epithelial–mesenchymal transition (EMT) characteristics .	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11803149	These results suggest that Epas1 promotes anti-tumor activity of CD8 T cells in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "Epas1", "promotes", "anti-tumor...
PMC11389534	The EBV‐encoded BILF1 mediates MAVS UFMylation, targeting it for lysosomal degradation and potentially disrupting NLRP3 inflammasome activation and IRF3 responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EBV‐encoded", ...
PMC9429973	Statistical tests were two-sided; p-values <0.05 were considered significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "tests", "were", "two-sided", ";", "p-values", "<", "0.05", "were", "co...
PMC9429973	Interestingly the cases with higher SRC showed a trend of reduced overall survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", "the", "cases", "with", "higher", "SRC", "showed", "a", ...
PMC11321678	Furthermore, the significance of the TF‐NTR regulatory circuits is underscored as prospective biomarkers and viable therapeutic targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "significance", ...
PMC2614415	Fragmented DNA was measured as a sub G0/G1 peak and was analyzed as a measure of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fragmented", "DNA", "was", "measured", "as", ...
PMC9429973	Consistent differences in TGFß pathway gene expression were also detected in AML patients of the TCGA dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "differences", "in", "TGFß", "pathwa...
PMC10840195	Fig. 3Twist is the key protein in the EMT and Wnt signalling pathway interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "3Twist", "is", "the", "key", "protein", "in", "the", ...
PMC11344246	Dharmacon siGENOME™ SMARTpool™ siRNAs targeting each gene candidate were purchased from Horizon Discovery (Dharmacon).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dharmacon", "siGENOME", "™", "SMARTpool", ...
PMC9046263	RNA was purified using DNase and quantified using NanoDrop 2000 (ThermoFisher Scientific) for a 260/280 value ~ 2.0, and reverse transcribed using the SuperScript First-Strand Synthesis RT-PCR kit (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11747467	We first collected the mRNA expression profile from TCGA-MIBC dataset and then conducted a differential expression analysis between basal/squamous and three other luminal subtypes (including LumNS, LumP, and LumU) of bladder cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	Together, these data demonstrated that the typical pattern of the polonaise movements was induced and initially maintained in the short-term, while there was no or little indication of robust PS formation or extension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	The anti-tumor effect of the concurrent ERK5 and CDK5 inhibition was due to decreased proliferation as shown by the decrease in Ki-67, a cell proliferation marker and increased cell death as shown by the increased number of Tunel-positive cells, a marker of apoptosis (Fig. 3C,D).Figure 3Co-inhibition of ERK5/CDK5 suppr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	Additionally, it was observed that ACYP2 was distributed in both the cytoplasm and nucleus of HCC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "it", "was", "obse...
PMC11730000	However, the cytotoxic and genotoxic effects of DOX are not limited to cancer cells, as it also damages healthy cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11686380	Original blots/gels of (A) and (B) are presented in Supplementary Figure S2 (A) and (B). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10170482	The ImageJ software (NIH, Bethesda, MD, USA) was used for image processing and quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ImageJ", "software", "(", ...
PMC11629461	Leibovitz's L‐15 medium (#PM151010) was from Procell (Wuhan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Leibovitz", "'s", "L‐15", "medium", "(", "#", "P...
PMC11721277	The labeled samples (n = 2) were kept at room temperature in a light-protected place and after 2 h and 4 h incubation, the percentage of release radioactivity from the Tc-labeled chlorin complex was measured using radio-ITLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678448	To confirm the reliability of our RNA-seq analysis, we chose hub genes (CD86, CCL5, CD8A, CXCL8, CTLA4, TNF, CD274, IL-10, IL-6, CXCL10, IFNG, and IL-17A) for further examination (Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	The second-generation P-gp inhibitors often caused interference with anticancer drugs and affected their pharmacokinetics, resulting in adverse side effects .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second-generation", "...
PMC11323699	We aimed to describe changes in CD47 expression with platinum therapy and their relationship with immune features and prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "aimed", "to", "describe", ...
PMC11483468	Extending the cell treatment time to 6 weeks increased the death rate of cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extending", "the", "cell", "treatment", "time", "to", "6", "week...
PMC11078693	Count the total number of cells for step j.f.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Count", "the", "total", "number", "of", "cells", "for", "step", "j.f", "." ] } ]
PMC11591030	NO.	[ { "tags": [ "O", "O" ], "tokens": [ "NO", "." ] } ]
PMC9429973	Among pts with wAIHA (n=16), 14 pts (88%) completed 12 wk of treatment; 8 (50%) and 12 (75%) achieved CR and PR, respectively, at any visit from Wk 6–12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11698348	Images were taken using Leica THUNDER imager 3D cell culture (Leica, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "taken", "using", "Leica", "THUNDER", "ima...
PMC11533140	Structure–activity relationship (SAR) analysis showed that the morpholine group could form a key hydrogen bond and that the pyrimidine group was the basic framework to maintain the inhibitory activity (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170	eIFs may become promising therapeutic targets for many tumors under the PI3K/AKT/mTOR pathway control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "eIFs", "may", "become", "promising", "therapeutic", "targets", "for", ...
PMC11752767	An international, phase 2 clinical trial on ITIL-168 is currently underway in advanced melanoma [NCT05050006].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "international", ",", "phase", "2...
PMC10729469	In the current study, we show that in APP/PS1 mice, adoptively transferred TCRAβ-Tregs significantly infiltrate the brain, while transferred polyclonal Tregs predominantly remain in the peripheral circulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	The mean CI value was 0.35, showing that the interaction in A2780-ADR cells is synergistic ( Figure 2C ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "CI",...
PMC11564405	Among the intricacies of the tumor immune process, the travel of effector T cells to the tumor site requires just as much time and efforts for researchers to explore clearly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Given the more rapid decay of Mecp2 at the protein compared to the mRNA level during the quiescence-proliferation transition, we speculated that Mecp2 is targeted by post-translational regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among the groups the rise in the mean platelet count after transfusion was significant among stable patients (group B) compared to unstable patients (group A) (P < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	Within the viral factories, these structures could also be detected as parallel stacked arrays that occasionally bind to viral membranes through loose contacts (Fig 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	Major limitations of AuNPs to clinical trials are the lack of quantity, small sizes of particles and limited understanding of the long-term consequences of gold accumulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	This study is one of the first studies to confirm the apoptotic effect of P. sidoides on a neuroblastoma cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ "Th...
PMC11774747	The CD19 target was the most widely studied to treat B-cell malignancies (3, 91, 92).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CD19", "target", "was", ...
PMC11806818	Exploration of Nanozyme Properties: Investigate the multifunctional catalytic abilities of nanozymes and the synergistic effects of various nanozyme combinations to enhance signal transduction performance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10976516	With advances in biomolecular techniques and our improved understanding of cancer biology and virology, it became possible to create viruses with higher tumor selectivity and enhanced oncolytic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	A quantitative comparison between the results at different PFA concentrations is difficult due to increased fluorescence quenching effects at higher concentrations of PFA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11499381	These halves do not fluoresce on their own, but when in close proximity, they can refold to create a fully functional fluorescent protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9096373	The median survival (D) in the APA + RT group was longer by 22 and 11 days compared with the RT and DDPs + RT groups (P<0.05), respectively. *,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766309	Quantitative real-time PCR assays were performed to detect YKT6 expression in cervical cancer cell lines and normal HEK cells to confirm the success of the bioinformatic analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11781181	The data that support the findings of this study have been deposited in the CNSA (https://db.cngb.org/cnsa/) of CNGBdb with accession number CNP0000970.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4485786	Tumor homogenates of individuals in each cohort were subjected to RT-PCR–based fragment length analysis for the major triggering receptors NKG2C, -D, and -E, DNAM-1, and NK receptors NKp30, −44, and −46.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087301	However, some tumor types such as hepatocellular carcinoma and glioblastoma might hijack the existing blood vessels in alternative to new vessel formation which is called “vessel co-option” influencing disease fate by affecting therapy response and survival status .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	GLUT1: control vs. HIF1β ***P = 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GLUT1", ":", "control", "vs.", "HIF1β", "", "", "*", "P", "=", "0.001", ...

PMC11697065

It is therefore not surprising that the dominant signature across all antibody-expressing clones, independent of secretion profiles, was time-point of cell collection especially given the fact that cell culture parameters such as feeding were implemented from day 3 of culture onward, further distinguishing D0 and D6 ti...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11467964

Furthermore, GO enrichment was performed, and the results demonstrated that DEBM cluster‐related genes were enriched in various important biological processes, such as the muscular process, extracellular matrix organization, extracellular structure organization, and muscle contraction.

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PMC6461034

Statistical analysis was performed using ordinary one‐way ANOVA.

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PMC9429973

Eleven patients (64.7%) received at least two doses of mRNA-based vaccines and six (35.3%) were fully vaccinated with vector-based vaccines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10891340

However, the antiviral effect of CCCP in DEFs has not been clarified yet.

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PMC8978939

Immunoprecipitation of GFP Trap showed a specific band of 25 kD for GFP alone and 50 kD on cells expressing GFP-pVHL-Venus Tag ( Figure 2A ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Patients with post-sternum diagnosis of hypo-MDS showed a significantly difference in five-year survival compared with patients with post-sternum diagnosis of AA (98.6% vs 86.1%, p=0.005).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740508

1 × 10 cells/well in 6-well plates were treated for 48 h, fixed with 66% ethanol/4C/2 h, and stored at 4C.

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PMC11680049

The fungicidal activity of plant extracts was determined by the growth of fungal mycelium.

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PMC11786704

The micrographs of capsules were obtained with confocal laser scanning microscopy (CLSM, Nikon A1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "micrographs", "of", "capsules", "were", ...

PMC11298021

Two groups were transfected with each mimic using TurboFect for 48 hours at a concentration of 50 nM. To investigate the impact of rapamycin on the cells, one group was subjected to rapamycin treatment alone at its IC50 concentration, another two groups received the same treatment procedure while being transfected with...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7823217

Swaminathan et al. developed bioprinted construct using pre-formed spheroids of human breast epithelial cell lines .

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PMC10907726

Scale bar: 10 μm. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "10", "μm", ".", "(" ] } ]

PMC10976516

The latter implies a further necessity to improve the use of cell-mediated OV therapy for optimal clinical applications against lung cancer.

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PMC11188874

Cells were transfected with the indicated sgRNA, incubated for 72 hours and then treated with each HDAC6 inhibitor (1 µmol/L).

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PMC11574271

In contrast, liver metastases were observed in both the J82-NC and J82-RON cell-injected mice, with the extent of hepatic damage being significantly greater in the J82-RON group compared to the J82-NC group (Fig. 7E).

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PMC11515150

The efficacy of adoptive transfer of CD5 CAR-NK cells warrants further efforts to clinical application for patients with T-cell hematologic malignancies in a clinical trial setting.

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PMC10818062

Second, PI levels increased upon PS inhibition via acceleration of the PI cycle by Nir2/3-mediated PI/PA exchange.

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PMC7582629

The loading vectors can make an orthonormal coordinate system able to reproduce both the total variable variance with all components and to reproduce the correlations.

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PMC11766350

Cells transfected with the anti-gfp shRNA plasmid showed significantly higher viability compared to the scrambled shRNA control (76.8% vs. 59.8% respectively, Figure 2a).

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PMC11225860

Slides were H&E stained and QuPath Bioimaging Analysis software performed for nucleus to cell ratio to identify polyploidy cells (B).

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PMC11747467

To further assess the relationship between RC48 and molecular subtypes, we first conducted a differential expression analysis comparing MIBC tissue to adjacent normal tissue.

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PMC11791264

Each bar represents the mean ± SD (n = 3).

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PMC8873393

D The average relative transcript levels within each cluster presented in Fig. 5B are shown, with the log2 expression values on the y axis and time on the x axis.

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PMC11632064

The following publicly available dataset was used: Skin Cutaneous Melanoma (TCGA, PanCancer Atlas). (

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PMC9370419

The RNA-seq results revealed that CUL4-DDB1-related downstream genes were reduced after being treated with estradiol benzoate.

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PMC11266100

After the EP treatment the cells were transferred into a flat-bottom 96-well plate, incubated for 10 min and growth media to the final 200 μL volume in each well was added.

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PMC8009078

For simplicity, from here onwards, phenylethyl-D-rutinoside, 8-geranylapigenin, Morusin, Kaempferol and Sanggenol L can be known as A1, A2, A3, A4 and A5, respectively.

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PMC11269933

The cell culture, plasmid transfection and imaged for fluorescence as mentioned in the section “BiFC Assay”.

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PMC9812014

HCV affects about 3% of the world's populace and is the leading cause of chronic liver disease.

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PMC9429973

OS and PFS rate at 1 year after infusion in GI bleeding group were significantly lower than those in non-bleeding group (OS 27.3% vs 57% (P = 0.0198), PFS 27.3% vs 60.9% (P = 0.0293)).3 cases(3/26,11.5%) died of GI bleeding and 10 cases (10/26,38.4%) died of disease progression.

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PMC9429973

K. L. Chai, C. Wellard, N. Aoki, E. M. Moore, B. Augustson, A. Bapat, H. A. Blacklock, W. J. Chng, R. Cooke, C. Forsyth, N. Hamad, S. J. Harrison, P. J. Ho, J. Hocking, I. H. Kerridge, J. S. Kim, K. Kim, T. King, G. J. McCaughan, P. Mollee, C. O. Morrissey, N. Murphy, H. Quach, X. N. Tan, A. Tso, K. Wong, A. Spencer, E...

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PMC7504302

Similarly, the BNC tumors exhibited concurrent activation of MAPK and PI3K pathways and cell lines derived from these tumors were sensitive to PI3K inhibitor BEZ-235 .

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PMC9621239

RT-qPCR was performed using TB Green Fast qPCR Mix (RR430, Takara, Japan).

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PMC11711345

However, in the BOILED-Egg (Brain Or Intestinal EstimateD) model, all the compounds had high GI absorption and BBB permeability values (Figure S3).

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PMC9429973

Median age was 63 (range 19–79) years, and most patients had an International Prognostic Index of 3–5 (61.9%).

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PMC11225860

The reduction of polyploidy in the combination therapy was seen during both the three- and five-day time points.

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PMC11513011

In keeping with the literature, this study also focuses on caspase-3 as a pivotal factor in bladder cancer apoptosis.

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PMC11190238

b Pie chart depicting the distribution of dynamic (gray) and stable (black) compartments across the cell lines at both epithelial and mesenchymal compartments.

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PMC10758402

DMF has also been reported to suppress cell proliferation in multiple breast cancer cell lines via inhibition of NFκB activity (22).

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PMC11719944

In Figure 7, the scatter plots illustrate the relationship between serum PRL levels and diagnosis time of T1D.

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PMC9611901

Testing strategies often are complex; they should be performed in some logical sequence, and usually start with the in vitro assays.

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PMC6803987

Semi-preparative HPLC was carried out on an Agilent 1260 liquid chromatography (LC) with a Zorbax SB-C18 column (5 μM, 9.4 mm × 250 mm) (Agilent, Santa Clara, CA, USA).

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PMC11721295

We isolated NLF-2522 from normal lung tissue of control mice.

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PMC11052306

Since the discovery of cisplatin in the 1960s and the success of its use to treat cancers , researchers in bioinorganic chemistry have first focused on platinum derivatives, which are of current use to treat testicular, ovarian, and lung cancers .

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PMC11422497

Silencing circ_SMA4 partially inhibited GISTs malignant progression.

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PMC8777939

To test whether etravirine can suppress angiogenesis in ovarian cancer, we observed HUVEC tube formation under media conditions with etravirine at the indicated concentrations.

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PMC8956657

The MERS-CoV ORF4b protein is a viral accessory protein that functions as an innate immune inhibitor (Fig. 1A) and strongly localizes to the nucleus, despite virus replication occurring exclusively within the cytoplasmic compartment.

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PMC11544122

Endocytosis was calculated as a decrease in cell surface receptors in agonist-treated cells compared with vehicle-treated cells after background subtraction from cells not transfected with the receptor.

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PMC9429973

Results: There were 26 patients included in this study, with a median age of 41 years and of which 58% (n=15) were female.

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PMC10607604

Indeed, OVCAR-8 cells, which are genetically less representative of HGSOCs than KURAMOCHI cells , are more tumorigenic , migrate faster (and Figure 1D), are more proliferative (and Figure 1B), and display more advanced epithelial–mesenchymal transition (EMT) characteristics .

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PMC11803149

These results suggest that Epas1 promotes anti-tumor activity of CD8 T cells in vivo.

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PMC11389534

The EBV‐encoded BILF1 mediates MAVS UFMylation, targeting it for lysosomal degradation and potentially disrupting NLRP3 inflammasome activation and IRF3 responses.

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PMC9429973

Statistical tests were two-sided; p-values <0.05 were considered significant.

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PMC9429973

Interestingly the cases with higher SRC showed a trend of reduced overall survival.

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PMC11321678

Furthermore, the significance of the TF‐NTR regulatory circuits is underscored as prospective biomarkers and viable therapeutic targets.

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PMC2614415

Fragmented DNA was measured as a sub G0/G1 peak and was analyzed as a measure of apoptosis.

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PMC9429973

Consistent differences in TGFß pathway gene expression were also detected in AML patients of the TCGA dataset.

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PMC10840195

Fig. 3Twist is the key protein in the EMT and Wnt signalling pathway interaction.

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PMC11344246

Dharmacon siGENOME™ SMARTpool™ siRNAs targeting each gene candidate were purchased from Horizon Discovery (Dharmacon).

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PMC9046263

RNA was purified using DNase and quantified using NanoDrop 2000 (ThermoFisher Scientific) for a 260/280 value ~ 2.0, and reverse transcribed using the SuperScript First-Strand Synthesis RT-PCR kit (Thermo Fisher Scientific).

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PMC11747467

We first collected the mRNA expression profile from TCGA-MIBC dataset and then conducted a differential expression analysis between basal/squamous and three other luminal subtypes (including LumNS, LumP, and LumU) of bladder cancer.

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PMC11087055

Together, these data demonstrated that the typical pattern of the polonaise movements was induced and initially maintained in the short-term, while there was no or little indication of robust PS formation or extension.

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PMC11473843

The anti-tumor effect of the concurrent ERK5 and CDK5 inhibition was due to decreased proliferation as shown by the decrease in Ki-67, a cell proliferation marker and increased cell death as shown by the increased number of Tunel-positive cells, a marker of apoptosis (Fig. 3C,D).Figure 3Co-inhibition of ERK5/CDK5 suppr...

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PMC11391695

Additionally, it was observed that ACYP2 was distributed in both the cytoplasm and nucleus of HCC cells.

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PMC11730000

However, the cytotoxic and genotoxic effects of DOX are not limited to cancer cells, as it also damages healthy cells.

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PMC11686380

Original blots/gels of (A) and (B) are presented in Supplementary Figure S2 (A) and (B). (

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PMC10170482

The ImageJ software (NIH, Bethesda, MD, USA) was used for image processing and quantification.

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PMC11629461

Leibovitz's L‐15 medium (#PM151010) was from Procell (Wuhan, China).

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PMC11721277

The labeled samples (n = 2) were kept at room temperature in a light-protected place and after 2 h and 4 h incubation, the percentage of release radioactivity from the Tc-labeled chlorin complex was measured using radio-ITLC.

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PMC11678448

To confirm the reliability of our RNA-seq analysis, we chose hub genes (CD86, CCL5, CD8A, CXCL8, CTLA4, TNF, CD274, IL-10, IL-6, CXCL10, IFNG, and IL-17A) for further examination (Figure 8).

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PMC9509578

The second-generation P-gp inhibitors often caused interference with anticancer drugs and affected their pharmacokinetics, resulting in adverse side effects .

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PMC11323699

We aimed to describe changes in CD47 expression with platinum therapy and their relationship with immune features and prognosis.

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PMC11483468

Extending the cell treatment time to 6 weeks increased the death rate of cells.

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PMC11078693

Count the total number of cells for step j.f.

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PMC11591030

NO.

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PMC9429973

Among pts with wAIHA (n=16), 14 pts (88%) completed 12 wk of treatment; 8 (50%) and 12 (75%) achieved CR and PR, respectively, at any visit from Wk 6–12.

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PMC11698348

Images were taken using Leica THUNDER imager 3D cell culture (Leica, Germany).

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PMC11533140

Structure–activity relationship (SAR) analysis showed that the morpholine group could form a key hydrogen bond and that the pyrimidine group was the basic framework to maintain the inhibitory activity (Figure 2).

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PMC7602170

eIFs may become promising therapeutic targets for many tumors under the PI3K/AKT/mTOR pathway control.

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PMC11752767

An international, phase 2 clinical trial on ITIL-168 is currently underway in advanced melanoma [NCT05050006].

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PMC10729469

In the current study, we show that in APP/PS1 mice, adoptively transferred TCRAβ-Tregs significantly infiltrate the brain, while transferred polyclonal Tregs predominantly remain in the peripheral circulation.

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PMC9684669

The mean CI value was 0.35, showing that the interaction in A2780-ADR cells is synergistic ( Figure 2C ).

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PMC11564405

Among the intricacies of the tumor immune process, the travel of effector T cells to the tumor site requires just as much time and efforts for researchers to explore clearly.

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PMC11095939

Given the more rapid decay of Mecp2 at the protein compared to the mRNA level during the quiescence-proliferation transition, we speculated that Mecp2 is targeted by post-translational regulation.

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PMC9429973

Among the groups the rise in the mean platelet count after transfusion was significant among stable patients (group B) compared to unstable patients (group A) (P < 0.001).

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PMC9910796

Within the viral factories, these structures could also be detected as parallel stacked arrays that occasionally bind to viral membranes through loose contacts (Fig 4C).

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PMC11551844

Major limitations of AuNPs to clinical trials are the lack of quantity, small sizes of particles and limited understanding of the long-term consequences of gold accumulation.

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PMC11679892

This study is one of the first studies to confirm the apoptotic effect of P. sidoides on a neuroblastoma cell line.

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PMC11774747

The CD19 target was the most widely studied to treat B-cell malignancies (3, 91, 92).

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PMC11806818

Exploration of Nanozyme Properties: Investigate the multifunctional catalytic abilities of nanozymes and the synergistic effects of various nanozyme combinations to enhance signal transduction performance.

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PMC10976516

With advances in biomolecular techniques and our improved understanding of cancer biology and virology, it became possible to create viruses with higher tumor selectivity and enhanced oncolytic activity.

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PMC9817179

A quantitative comparison between the results at different PFA concentrations is difficult due to increased fluorescence quenching effects at higher concentrations of PFA.

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PMC11499381

These halves do not fluoresce on their own, but when in close proximity, they can refold to create a fully functional fluorescent protein.

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PMC9096373

The median survival (D) in the APA + RT group was longer by 22 and 11 days compared with the RT and DDPs + RT groups (P<0.05), respectively. *,

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PMC11766309

Quantitative real-time PCR assays were performed to detect YKT6 expression in cervical cancer cell lines and normal HEK cells to confirm the success of the bioinformatic analysis.

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PMC11781181

The data that support the findings of this study have been deposited in the CNSA (https://db.cngb.org/cnsa/) of CNGBdb with accession number CNP0000970.

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PMC4485786

Tumor homogenates of individuals in each cohort were subjected to RT-PCR–based fragment length analysis for the major triggering receptors NKG2C, -D, and -E, DNAM-1, and NK receptors NKp30, −44, and −46.

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PMC11087301

However, some tumor types such as hepatocellular carcinoma and glioblastoma might hijack the existing blood vessels in alternative to new vessel formation which is called “vessel co-option” influencing disease fate by affecting therapy response and survival status .

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PMC11377827

GLUT1: control vs. HIF1β ***P = 0.001.

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