OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10898159	FGF2 binds to and activates its receptors FGFR, mediating the reactivation of KIT and MAPK pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGF2", "binds", "to", "and", "activates", "...
PMC11718809	Differential mRNA data were sourced from our group’s published papers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differential", "mRNA", "data", "were", "sourced", "from", "our", "group", "’s", "publ...
PMC9856122	In addition to tetrandrine two other alkaloids including fangchinoline, and CEP were investigated against human coronavirus OC43 (HCoV-OC43) using a Medical Research Council cell strain 5 (MRC-5) fibroblast lung cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Cells were selected and added to 96-well plates when they reached the logarithmic growth phase, with 100 µL cell suspension and 1,000 cells per well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8701144	After digestion, the samples were centrifuged at 14,000× g for 10 min, trypsin was inactivated by adding 100 µL 1% TFA, and the samples were again centrifuged at 14,000× g for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705901	p < 0.05 Luciferase reporter gene assay showing the effect of base substitution due to rs1042778 on miRNA binding in a SH-SY5Y and b H4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "...
PMC9429973	In the subgroup of AML patients who achieved CR/CRi, IPSS-R was predictive of RFS in univariate analysis (p=<0.001), and multivariate analysis (ref low/int) (p=0.001, HR=2.08 for very high risk).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	Decreased p-mTOR, but not mTOR, was also detected in A498 cells after ACLY knockdown or inhibition (P = 0.018, Fig. 6c; P = 0.027, Fig. S6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Ð. Pavlović, N. Tošić, B. Zukić, I. Marjanović, Z. Pravdić, N. Suvajdžić Vuković, S. Pavlović, V. Gašić Institute of Molecular Genetics and Genetic Engineering; Clinic of Hematology; Faculty of Medicine, Belgrade, Serbia Background: Acute myeloid leukemia (AML) is a heterogeneous malignant disease, that accounts for 80...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	n = 3 In order to evaluate whether the secretomes of other types of bovine stem/progenitor cells affect bacterial growth similarly, CM was collected from bovine mesenchymal stem/stomal cells (MSCs) isolated from adipose tissue (AD), bone marrow (BM) and peripheral blood (PB), and evaluated for antimicrobial effects aga...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Nonetheless, our data indicate that expression levels of polyGR are at least in the physiological range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "our", "data", "indicate", ...
PMC6901583	Scale bar: 25 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "25", "μm", "." ] } ]
PMC10850553	M; size marker. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "M", ";", "size", "marker", ".", "(" ] } ]
PMC11594806	Tyrosine kinase inhibitors (TKIs) have emerged as a targeted approach for this pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tyrosine", "kinase", "inhibitors", "(", "TKIs", ")", "have"...
PMC11499381	Emax values presented as a percentage of the matched WT curve included in each experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emax", "values", "presented", "as", "a", "percentage", "of"...
PMC11720808	Secondly, we investigated the molecular mechanism via which TLR4 influences NF-κB activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondly", ",", "we", "investigated", "the", "molecular", "mechanism", "via...
PMC11659921	Mutation frequency analysis of angiogenesis and stemness related genes in OV. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutation", "frequency", "analysis", "of", "angiogenesis", "and", "stemness", "related"...
PMC9429973	The median age was 13(4-69) years old.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "was", "13(4", "-", "69", ")", "years", "old", "." ] } ]
PMC9583612	Site-level measurements from SeekOps and Bridger are used to develop measurement-informed inventory (MII) estimates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Site-level", "measurements", "from", "SeekOps", "and", ...
PMC7519871	Cisplatin is being used extensively to treat cervical cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "is", "being", "used", "extensively", "to", "treat", "cervical", "cancer", "." ] } ]
PMC11585565	Further investigation into the mechanisms regulating CNNM4 expression and protein stability may reveal potential therapeutic avenues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "investigation", "into", "the", "mechanisms", ...
PMC11670954	Average relative immunofluorescence intensity of ROCK2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Average", "relative", "immunofluorescence", "intensity", "of", "ROCK2", ".", "(" ] } ]
PMC9429973	The median duration of follow-up and ORR ranged across cohorts (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "duration", "of", "follow-up", "and", "ORR", "ranged", ...
PMC11052306	Both the non-complexed and complexed dendrimers and the corresponding monomers were tested for their cytotoxicity activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "the", "non-complexed", "and", "complexed", "de...
PMC11422497	Inhibition of circ_SMA4 expression or interference with its interaction with miR-494-3p could potentially suppress GISTs cell proliferation and metastasis, providing a new avenue for therapeutic intervention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	However, the molecular mechanisms governing its signaling mechanism remains largely unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "molecular", "mechanisms", "governing", "its", "signaling", ...
PMC7334607	Yet, because the control, not experimental, evolutionary replicates changed over time, it is less clear whether or not this negative log-ratio should be interpreted as a move toward sensitivity in the experimental replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10440586	Correlation between CD99 and cell state markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "between", "CD99", "and", "cell", "state", "markers", "." ] } ]
PMC11487720	Both actin and α-tubulin are housekeeping proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "actin", "and", "α-tubulin", "are", "housekeeping", "proteins", "." ] } ]
PMC9429973	M. S. Dal, B. Uncu Ulu, A. Uzay, O. M. Akay, S. Besisik, M. N. Yenerel, S. Celik, L. Kaynar, O. K. Yucel, B. Deveci, M. Sonmez, O. Mehtap, H. S. Bekoz, C. Sunu, O. Salim, T. Ulas, S. Karti, F. Altuntas, B. Ferhanoglu, T. Firatli Tuglular Hematology and Bone marrow transplantation, Ankara Oncology Training and Education...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11361748	For topical treatments involving CXCR2 and CXCR3 inhibitors, 100 μm of AZD5069 (CXCR2 inhibitor; Cayman Chemical Company #28297) and 100 μm of AMG487 (CXCR3 inhibitor; Tocris #4487) were mixed together in 20 μl of DMSO and applied to the dorsal side of mouse ear 30 min before the second TPA treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549062	Confined mode represents the status where particles rarely move, with a diffusive parameter less than 0.9, and their trajectories appear as dots, whereas the diffusive parameter of directed particles is > 1.2, showing the linear trajectories (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	Heavy phosphorylation of Ki-67 may facilitate the formation of a negatively charged barrier and strengthen the effect of Ki-67 in preventing nuclear lipid invasion into the intrachromosomal regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	Fig. 1siRNA-mediated knockdown of P300/CBP unveils a pivotal role in ES.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1siRNA-mediated", "knockdown", "of", "P300/CBP", "unveils", "a", "pivotal", "role",...
PMC11767582	5-(2-bromo-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (3k): Starting from 2h (0.11 g, 0.5 mmol) and following general procedure D, compound 3k was purified by chromatography, eluting with n-hexane-EtOAc (1:1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	The A673 cell line is often used to establish ES xenograft tumors in mouse models (15–17).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "A673", "cell", "line", ...
PMC8956657	F Crystal structure of MERS-CoV ORF4b NLS bound to IMPα3 at 2.5 Å resolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Crystal", "structure", "of", "MERS-CoV", "ORF4b", "NLS", "b...
PMC9429973	Aims: Utilizing an AdCAR-T cell approach to overcome well described obstacles in AML we evaluated several key parameters of our platform, including cytotoxicity, AM internalization and serial targeting capability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	HGAL’s phosphorylation by SYK has been demonstrated in vitro using recombinant TRX-HGAL and SYK, with SYK phosphorylating HGAL at pY86/107/128 sites, and pY80 (8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	The methanol extracts of F. benghalensis leaves exhibited larvicidal activity against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi mosquito larvae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "metha...
PMC11552389	Figure 1Bioinformatics analyses of FOXN3 expression. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1Bioinformatics", "analyses", "of", "FOXN3", "expression", ".", "(" ] } ]
PMC11806106	However, the analgetic effects of the opioid agonists are accompanied by severe side effects, like respiratory depression and addiction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "t...
PMC11026382	However the effect of most mutations on catalysis is unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", "the", "effect", "of", "most", "mutations", "on", "catalysis", "is", "unknown", ...
PMC11453018	Additionally, GSEA revealed a more pronounced impact on the cell cycle in iP300w-treated ES cell lines compared to other cancer cell lines (p = 2.18e-4; Reactome: cell cycle; Fig. 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6102174	Thus, TCMs maybe have advantages in treating HBV infection with multi-component and multi-target properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "TCMs", "maybe", "have", "advantages", "in", ...
PMC11461833	Hutchinson–Gilfor progeria syndrome (HGPS) is caused by a mutation in Lamin A resulting in the production of a protein called progerin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11409031	F, G) Evaluate the survival and receiver operating characteristic (ROC) curves for OV patients classified into high-risk and low-risk groups in the training and validation datasets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Primary endpoints were ORR (main) and safety (safety expansion).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "endpoints", "were", "ORR", "(", "main", ")", "and", "safet...
PMC11519788	Five-week-old male athymic nude mice (HFK Bioscience, China) were randomly categorized into two groups (n = 6 per group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11628309	Mammalian and non-mammalian models have been utilized to create animals that overexpress proteins linked to PD, such as α-Synuclein, Synphilin-1, Parkin, LRRK2, PINK1, etc., (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Due to novel technologies pathogenetic concepts of BPDCN underlie a dynamic process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "novel", "technologies", "pathogenetic", "concepts", "of", "BPDCN", ...
PMC9429973	The incidence is about 6-20% in the relapsed MM patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incidence", "is", "about", "6", "-", "20", "%", "in", "t...
PMC11434983	All reagents and starting materials were purchased from commercial suppliers and used without further purification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "reagents", "and", "starting", "materials", "were", "...
PMC10212663	The prediction model was established via Lasso regression method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prediction", "model", "was", "established", "via", "Lasso", "regression", "method", "." ] } ]
PMC9776316	These data reveal that XRCC4 promotes cisplatin-resistant potential and that targeting XRCC4 sensitizes cisplatin-resistant ovarian cancer cells to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "reveal", "that",...
PMC11599565	These changes were primarily accompanied by the time-dependent accumulation of some TFs such as PAX6, PAX9 and Slug, however, are probably supported by EMT as indicated by the accumulation of Vimentin (Fig. 3, Panel C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	One notable example is Dimethyl fumarate (DMF), an FDA-approved drug for multiple sclerosis, which has shown significant potential in enhancing the activity of vesicular stomatitis virus (VSVΔ51) and various oncolytic HSV-1 strains in different cancer cell lines and mouse models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10605143	HSF1 is a well-known regulator of the cell response induced by proteotoxic stress (i.e., heat shock, exposure to heavy metals and others).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11082662	The SMPDL3B was initially identified as a glycosylphosphatidylinositol (GPI)-anchored factor (16,17), and subsequent discoveries have shed light on its crucial biological functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11770130	a Food intake of control and Ntsr2 AKO mice (n = 7–8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Food", "intake", "of", "control", "and", "Ntsr2", "AKO", ...
PMC11357960	These results suggested that the percentage change in mRNA level of 3 SUMO machinery components (SUMO1, SUMO3 and UBE2I), either alone or in combination, could to some extent predict clinical response to anti-PD-1 immunotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients were invited to participate via flyers that were handed out by accredited haematologists or had the possibility to fill out the survey on site on tablets provided in the hospitals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763533	We also visually compared the bioluminescent activity using images obtained from a photographic camera adapted to a handmade black Styrofoam box.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "vis...
PMC10667689	The mRNA expression of ATGL was increased in Gal-9 groups compared to the PMA and control group in THP-1 (C); however, the decrease and increase pattern of this enzyme in Gal-9 groups compared to the PMA and control groups in the HL-60 cell line seems to be impressed by PMA stimulation, as it decreased at 72 h (D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	The expected molecular weight of GFP-ATF6α_TM--LD before cleavage is 67 and 45 kDa post-FURIN cleavage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expected", "molecular", "weight", "of", ...
PMC11612508	Fig. 6Zeta potential (A) and DLS analysis (B) of magnetic microspheres.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Zeta", "potential", "(", "A", ")", "and", "D...
PMC4112127	Ten colonies from each cloning reaction were grown in LB medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "colonies", "from", "each", "cloning", "reaction", "were", "grown", "in", "LB",...
PMC9429973	The median duration of IRd treatment – 7.5 mos (IQR, 3.9-18.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "duration", "of", "IRd", "treatment", ...
PMC11768281	Collectively, these findings highlight the multifaceted roles of γδ T-cells in malaria immunity, spanning the liver and blood stages of the parasite’s life cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489275	Similar results were observed in another lymphocyte grouping method according to the tertile of the baseline lymphocytes (Supplementary Table S1), the specific group definition can be found in the methods part.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	Structural studies have shown that MHC-like molecule MR1 buries small metabolite antigens so that they do not contact TCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Structural", "studies", "have", "...
PMC11286266	Arrows indicate GFP-ATF6α_LD::Golgi co-localisation.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Arrows", "indicate", "GFP-ATF6α_LD::Golgi", "co-localisation", "." ] } ]
PMC11782780	Cell sphere-forming ability was assessed using sphere formation experiments, which revealed that the group with miR-301b-3p overexpression exhibited significantly higher cell sphere-forming ability than the control group, while further overexpression of EBF3 weakened the stimulatory effect of overexpression of miR-301b...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	Differences between groups were compared using an unpaired, two-tailed t test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "between", "groups", "were", "compared", "using", "an", "unpaired", ...
PMC11525028	The cells in the upper chambers were removed, and the cells in the lower chambers were observed under a microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "i...
PMC6468656	Renal cell carcinoma (RCC), also called renal adenocarcinoma, comprises 90–95% of kidney-derived tumors, and is a form of kidney cancer that arises from the cells of the renal tubule .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	Rows are independently normalized and sorted based on extent of recovery to initial expression upon light stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rows", "are", "independently", "normalized", "and...
PMC3765139	Tumor growth was assessed once a week using a caliper and the actual tumor mass was estimated by calculating the volume according to the ellipsoid volume formula: 4/3 π (½ × lenght × width × height).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700340	Growth inhibition= (optical density of control wells-optical density of treated wells)/(optical density of control wells)*100% Molecular docking The chemical structures of linagliptin were illustrated using ChemDraw software (CambridgeSoft, USA) and subsequently optimized using the Chem3D version.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	Interestingly, the amplitude of the H3K27ac peak near the KCNN1 promoter decreases after seven days of treatment, that is, after silencing of EWS::FLI1 (Fig. 3B, lower panel), confirming the decreased expression of KCNN1 shown in Fig. 2A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	However, the EPR effect of liposomes is not sufficient to increase the amount of drug reaching the focal area to a satisfactory concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11535726	Their conidiogenous cells are mono- to polytretic, integrated, terminal or lateral, doliiform or lageniform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "conidiogenous", "cells", "are", "mono-",...
PMC9429973	RG6234 induced rapid depletion of MM cells, as demonstrated by a decrease of sBCMA in the plasma of responding pts already 8 days after the first administration (median 33.5% reduction from baseline in responding pts; n=15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	Combined treatment with MRX-2843 and BCL-2 inhibitors venetoclax or navitoclax provided enhanced therapeutic activity compared to single agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combined", "treatment", "with", "MRX-2843", ...
PMC11476837	Then, doxorubicin at concentrations 1, 10, and 100 nM was added for a subsequent 24 h. Finally, 10 μL of resazurin salt was added to each well, and the plates were incubated again for 2 h. The fluorescence was measured with HT microplate reader Synergy HT (BioTek Instruments, Winooski, VT, USA) using λex = 530/25 and λ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752740	Rich in bioactive compounds, pistachio hull extract enhances the action of CFZ on the proteasome, targeting key players such as MDR1, MRP1, NF-κB, and Caspase-3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973085	From the results of docking study, we noticed that the highest binding interactions were found between the pyridine derivatives 4d, 4f, 5c, 5d, and 7b with 4k9g of colon cancer (−9.4430 to −8.0733 kcal/mol) which is compatible with experimental results of the highest activity against colon cancer HCT-116 (Table 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Restrictions on employing more staff.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Restrictions", "on", "employing", "more", "staff", "." ] } ]
PMC10976516	For lung cancer, like most solid cancers, this means optimization of intrinsic features of CCs such as increased tropism for pro-inflammatory tissues in the case of MSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	LAMIN B1 was used to identify nuclear and TUBULIN cytoplasmic fractions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAMIN", "B1", "was", "used", "to", "identify", "nuclear", "and", "TUBULIN", "cytoplas...
PMC10955424	To identify metabolites that are prominent in malignant ascites, we used LC-MS/MS (Figs. 7, S1 and Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "identi...
PMC9429973	D+28 DC but not morphological remission in BM identifies pts at high risk for relapse after HSCT, allowing for additional post-HSCT strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D+28", ...
PMC10994876	The disruption of either cellular proliferation or apoptosis serves as a catalyst for the development and progression of cancer (Loftus et al. 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11786600	The suspension was stored in a 37 °C water bath for 6 h. 3.0 mL of solution was taken out from the dissolution medium, and the absorbance was detected by a UV-visible spectrophotometer (UV-1780, SHIMADZU).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	We hypothesize that because CCCP treatment of infected cells induces mitophagy and removes damaged cells resulting in a downregulation of ROS levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "hypoth...
PMC6684588	Inhibitory activity of ACE-083 was measured in dual-luciferase reporter assays conducted with A204 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Inhibitory", "activity", "of", "ACE-083", "was", "measured", ...
PMC11578343	Sylgard 184 PDMS (Dow Corning) was mixed at a 10:1 w/w ratio of elastomer to curing agent, degassed, poured onto the master, and subsequently cured on a hotplate at 80 °C for 2 h. A slab of PDMS with the embedded microfluidic channel was excised from the master, and inlet and outlet holes were created using a 1 mm biop...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	TNF-α was also induced by stimulation with OSM in the renal fibroblasts, while the expression of MCP-1 was not affected by OSM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TNF-α",...
PMC10092581	Error bars indicate SD.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "indicate", "SD", "." ] } ]
PMC9429973	All patients underwent iPET/iCT (iCT=52 (81.3%); iPET=12 (18.8%)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "underwent", "iPET/iCT", "(", ...

PMC10898159

FGF2 binds to and activates its receptors FGFR, mediating the reactivation of KIT and MAPK pathways .

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PMC11718809

Differential mRNA data were sourced from our group’s published papers .

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PMC9856122

In addition to tetrandrine two other alkaloids including fangchinoline, and CEP were investigated against human coronavirus OC43 (HCoV-OC43) using a Medical Research Council cell strain 5 (MRC-5) fibroblast lung cell line.

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PMC11588008

Cells were selected and added to 96-well plates when they reached the logarithmic growth phase, with 100 µL cell suspension and 1,000 cells per well.

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PMC8701144

After digestion, the samples were centrifuged at 14,000× g for 10 min, trypsin was inactivated by adding 100 µL 1% TFA, and the samples were again centrifuged at 14,000× g for 10 min.

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PMC11705901

p < 0.05 Luciferase reporter gene assay showing the effect of base substitution due to rs1042778 on miRNA binding in a SH-SY5Y and b H4.

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PMC9429973

In the subgroup of AML patients who achieved CR/CRi, IPSS-R was predictive of RFS in univariate analysis (p=<0.001), and multivariate analysis (ref low/int) (p=0.001, HR=2.08 for very high risk).

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PMC11283030

Decreased p-mTOR, but not mTOR, was also detected in A498 cells after ACLY knockdown or inhibition (P = 0.018, Fig. 6c; P = 0.027, Fig. S6).

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PMC9429973

Ð. Pavlović, N. Tošić, B. Zukić, I. Marjanović, Z. Pravdić, N. Suvajdžić Vuković, S. Pavlović, V. Gašić Institute of Molecular Genetics and Genetic Engineering; Clinic of Hematology; Faculty of Medicine, Belgrade, Serbia Background: Acute myeloid leukemia (AML) is a heterogeneous malignant disease, that accounts for 80...

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PMC11566417

n = 3 In order to evaluate whether the secretomes of other types of bovine stem/progenitor cells affect bacterial growth similarly, CM was collected from bovine mesenchymal stem/stomal cells (MSCs) isolated from adipose tissue (AD), bone marrow (BM) and peripheral blood (PB), and evaluated for antimicrobial effects aga...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11001582

Nonetheless, our data indicate that expression levels of polyGR are at least in the physiological range.

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PMC6901583

Scale bar: 25 μm.

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PMC10850553

M; size marker. (

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "M", ";", "size", "marker", ".", "(" ] } ]

PMC11594806

Tyrosine kinase inhibitors (TKIs) have emerged as a targeted approach for this pathway.

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PMC11499381

Emax values presented as a percentage of the matched WT curve included in each experiment.

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PMC11720808

Secondly, we investigated the molecular mechanism via which TLR4 influences NF-κB activation.

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PMC11659921

Mutation frequency analysis of angiogenesis and stemness related genes in OV. (

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PMC9429973

The median age was 13(4-69) years old.

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PMC9583612

Site-level measurements from SeekOps and Bridger are used to develop measurement-informed inventory (MII) estimates.

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PMC7519871

Cisplatin is being used extensively to treat cervical cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "is", "being", "used", "extensively", "to", "treat", "cervical", "cancer", "." ] } ]

PMC11585565

Further investigation into the mechanisms regulating CNNM4 expression and protein stability may reveal potential therapeutic avenues.

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PMC11670954

Average relative immunofluorescence intensity of ROCK2. (

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PMC9429973

The median duration of follow-up and ORR ranged across cohorts (Table).

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PMC11052306

Both the non-complexed and complexed dendrimers and the corresponding monomers were tested for their cytotoxicity activity.

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PMC11422497

Inhibition of circ_SMA4 expression or interference with its interaction with miR-494-3p could potentially suppress GISTs cell proliferation and metastasis, providing a new avenue for therapeutic intervention.

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PMC8427838

However, the molecular mechanisms governing its signaling mechanism remains largely unknown.

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PMC7334607

Yet, because the control, not experimental, evolutionary replicates changed over time, it is less clear whether or not this negative log-ratio should be interpreted as a move toward sensitivity in the experimental replicates.

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PMC10440586

Correlation between CD99 and cell state markers.

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PMC11487720

Both actin and α-tubulin are housekeeping proteins.

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PMC9429973

M. S. Dal, B. Uncu Ulu, A. Uzay, O. M. Akay, S. Besisik, M. N. Yenerel, S. Celik, L. Kaynar, O. K. Yucel, B. Deveci, M. Sonmez, O. Mehtap, H. S. Bekoz, C. Sunu, O. Salim, T. Ulas, S. Karti, F. Altuntas, B. Ferhanoglu, T. Firatli Tuglular Hematology and Bone marrow transplantation, Ankara Oncology Training and Education...

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PMC11361748

For topical treatments involving CXCR2 and CXCR3 inhibitors, 100 μm of AZD5069 (CXCR2 inhibitor; Cayman Chemical Company #28297) and 100 μm of AMG487 (CXCR3 inhibitor; Tocris #4487) were mixed together in 20 μl of DMSO and applied to the dorsal side of mouse ear 30 min before the second TPA treatment.

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PMC11549062

Confined mode represents the status where particles rarely move, with a diffusive parameter less than 0.9, and their trajectories appear as dots, whereas the diffusive parameter of directed particles is > 1.2, showing the linear trajectories (Figure 2A).

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PMC11786767

Heavy phosphorylation of Ki-67 may facilitate the formation of a negatively charged barrier and strengthen the effect of Ki-67 in preventing nuclear lipid invasion into the intrachromosomal regions.

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PMC11453018

Fig. 1siRNA-mediated knockdown of P300/CBP unveils a pivotal role in ES.

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PMC11767582

5-(2-bromo-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (3k): Starting from 2h (0.11 g, 0.5 mmol) and following general procedure D, compound 3k was purified by chromatography, eluting with n-hexane-EtOAc (1:1).

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PMC10587429

The A673 cell line is often used to establish ES xenograft tumors in mouse models (15–17).

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PMC8956657

F Crystal structure of MERS-CoV ORF4b NLS bound to IMPα3 at 2.5 Å resolution.

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PMC9429973

Aims: Utilizing an AdCAR-T cell approach to overcome well described obstacles in AML we evaluated several key parameters of our platform, including cytotoxicity, AM internalization and serial targeting capability.

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PMC11518702

HGAL’s phosphorylation by SYK has been demonstrated in vitro using recombinant TRX-HGAL and SYK, with SYK phosphorylating HGAL at pY86/107/128 sites, and pY80 (8).

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PMC11653533

The methanol extracts of F. benghalensis leaves exhibited larvicidal activity against Culex quinquefasciatus, Aedes aegypti, and Anopheles stephensi mosquito larvae.

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PMC11552389

Figure 1Bioinformatics analyses of FOXN3 expression. (

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PMC11806106

However, the analgetic effects of the opioid agonists are accompanied by severe side effects, like respiratory depression and addiction.

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PMC11026382

However the effect of most mutations on catalysis is unknown.

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PMC11453018

Additionally, GSEA revealed a more pronounced impact on the cell cycle in iP300w-treated ES cell lines compared to other cancer cell lines (p = 2.18e-4; Reactome: cell cycle; Fig. 3H).

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PMC6102174

Thus, TCMs maybe have advantages in treating HBV infection with multi-component and multi-target properties.

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PMC11461833

Hutchinson–Gilfor progeria syndrome (HGPS) is caused by a mutation in Lamin A resulting in the production of a protein called progerin.

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PMC11409031

F, G) Evaluate the survival and receiver operating characteristic (ROC) curves for OV patients classified into high-risk and low-risk groups in the training and validation datasets.

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PMC9429973

Primary endpoints were ORR (main) and safety (safety expansion).

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PMC11519788

Five-week-old male athymic nude mice (HFK Bioscience, China) were randomly categorized into two groups (n = 6 per group).

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PMC11628309

Mammalian and non-mammalian models have been utilized to create animals that overexpress proteins linked to PD, such as α-Synuclein, Synphilin-1, Parkin, LRRK2, PINK1, etc., (

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PMC9429973

Due to novel technologies pathogenetic concepts of BPDCN underlie a dynamic process.

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PMC9429973

The incidence is about 6-20% in the relapsed MM patients.

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PMC11434983

All reagents and starting materials were purchased from commercial suppliers and used without further purification.

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PMC10212663

The prediction model was established via Lasso regression method.

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PMC9776316

These data reveal that XRCC4 promotes cisplatin-resistant potential and that targeting XRCC4 sensitizes cisplatin-resistant ovarian cancer cells to cisplatin.

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PMC11599565

These changes were primarily accompanied by the time-dependent accumulation of some TFs such as PAX6, PAX9 and Slug, however, are probably supported by EMT as indicated by the accumulation of Vimentin (Fig. 3, Panel C).

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PMC11209164

One notable example is Dimethyl fumarate (DMF), an FDA-approved drug for multiple sclerosis, which has shown significant potential in enhancing the activity of vesicular stomatitis virus (VSVΔ51) and various oncolytic HSV-1 strains in different cancer cell lines and mouse models .

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PMC10605143

HSF1 is a well-known regulator of the cell response induced by proteotoxic stress (i.e., heat shock, exposure to heavy metals and others).

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PMC11082662

The SMPDL3B was initially identified as a glycosylphosphatidylinositol (GPI)-anchored factor (16,17), and subsequent discoveries have shed light on its crucial biological functions.

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PMC11770130

a Food intake of control and Ntsr2 AKO mice (n = 7–8).

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PMC11357960

These results suggested that the percentage change in mRNA level of 3 SUMO machinery components (SUMO1, SUMO3 and UBE2I), either alone or in combination, could to some extent predict clinical response to anti-PD-1 immunotherapy.

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PMC9429973

Patients were invited to participate via flyers that were handed out by accredited haematologists or had the possibility to fill out the survey on site on tablets provided in the hospitals.

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PMC11763533

We also visually compared the bioluminescent activity using images obtained from a photographic camera adapted to a handmade black Styrofoam box.

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PMC10667689

The mRNA expression of ATGL was increased in Gal-9 groups compared to the PMA and control group in THP-1 (C); however, the decrease and increase pattern of this enzyme in Gal-9 groups compared to the PMA and control groups in the HL-60 cell line seems to be impressed by PMA stimulation, as it decreased at 72 h (D).

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PMC11286266

The expected molecular weight of GFP-ATF6α_TM--LD before cleavage is 67 and 45 kDa post-FURIN cleavage.

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PMC11612508

Fig. 6Zeta potential (A) and DLS analysis (B) of magnetic microspheres.

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PMC4112127

Ten colonies from each cloning reaction were grown in LB medium.

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PMC9429973

The median duration of IRd treatment – 7.5 mos (IQR, 3.9-18.0).

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PMC11768281

Collectively, these findings highlight the multifaceted roles of γδ T-cells in malaria immunity, spanning the liver and blood stages of the parasite’s life cycle.

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PMC11489275

Similar results were observed in another lymphocyte grouping method according to the tertile of the baseline lymphocytes (Supplementary Table S1), the specific group definition can be found in the methods part.

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PMC11785489

Structural studies have shown that MHC-like molecule MR1 buries small metabolite antigens so that they do not contact TCR.

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PMC11286266

Arrows indicate GFP-ATF6α_LD::Golgi co-localisation.

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PMC11782780

Cell sphere-forming ability was assessed using sphere formation experiments, which revealed that the group with miR-301b-3p overexpression exhibited significantly higher cell sphere-forming ability than the control group, while further overexpression of EBF3 weakened the stimulatory effect of overexpression of miR-301b...

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PMC4112127

Differences between groups were compared using an unpaired, two-tailed t test.

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PMC11525028

The cells in the upper chambers were removed, and the cells in the lower chambers were observed under a microscope.

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PMC6468656

Renal cell carcinoma (RCC), also called renal adenocarcinoma, comprises 90–95% of kidney-derived tumors, and is a form of kidney cancer that arises from the cells of the renal tubule .

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PMC11306331

Rows are independently normalized and sorted based on extent of recovery to initial expression upon light stimulation.

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PMC3765139

Tumor growth was assessed once a week using a caliper and the actual tumor mass was estimated by calculating the volume according to the ellipsoid volume formula: 4/3 π (½ × lenght × width × height).

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PMC11700340

Growth inhibition= (optical density of control wells-optical density of treated wells)/(optical density of control wells)*100% Molecular docking The chemical structures of linagliptin were illustrated using ChemDraw software (CambridgeSoft, USA) and subsequently optimized using the Chem3D version.

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PMC11706776

Interestingly, the amplitude of the H3K27ac peak near the KCNN1 promoter decreases after seven days of treatment, that is, after silencing of EWS::FLI1 (Fig. 3B, lower panel), confirming the decreased expression of KCNN1 shown in Fig. 2A.

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PMC11144200

However, the EPR effect of liposomes is not sufficient to increase the amount of drug reaching the focal area to a satisfactory concentration.

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PMC11535726

Their conidiogenous cells are mono- to polytretic, integrated, terminal or lateral, doliiform or lageniform.

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PMC9429973

RG6234 induced rapid depletion of MM cells, as demonstrated by a decrease of sBCMA in the plasma of responding pts already 8 days after the first administration (median 33.5% reduction from baseline in responding pts; n=15).

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PMC11352666

Combined treatment with MRX-2843 and BCL-2 inhibitors venetoclax or navitoclax provided enhanced therapeutic activity compared to single agents.

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PMC11476837

Then, doxorubicin at concentrations 1, 10, and 100 nM was added for a subsequent 24 h. Finally, 10 μL of resazurin salt was added to each well, and the plates were incubated again for 2 h. The fluorescence was measured with HT microplate reader Synergy HT (BioTek Instruments, Winooski, VT, USA) using λex = 530/25 and λ...

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PMC11752740

Rich in bioactive compounds, pistachio hull extract enhances the action of CFZ on the proteasome, targeting key players such as MDR1, MRP1, NF-κB, and Caspase-3.

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PMC8973085

From the results of docking study, we noticed that the highest binding interactions were found between the pyridine derivatives 4d, 4f, 5c, 5d, and 7b with 4k9g of colon cancer (−9.4430 to −8.0733 kcal/mol) which is compatible with experimental results of the highest activity against colon cancer HCT-116 (Table 4).

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PMC10936243

Restrictions on employing more staff.

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PMC10976516

For lung cancer, like most solid cancers, this means optimization of intrinsic features of CCs such as increased tropism for pro-inflammatory tissues in the case of MSCs.

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PMC10810426

LAMIN B1 was used to identify nuclear and TUBULIN cytoplasmic fractions.

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PMC10955424

To identify metabolites that are prominent in malignant ascites, we used LC-MS/MS (Figs. 7, S1 and Table S1).

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PMC9429973

D+28 DC but not morphological remission in BM identifies pts at high risk for relapse after HSCT, allowing for additional post-HSCT strategies.

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PMC10994876

The disruption of either cellular proliferation or apoptosis serves as a catalyst for the development and progression of cancer (Loftus et al. 2022).

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PMC11786600

The suspension was stored in a 37 °C water bath for 6 h. 3.0 mL of solution was taken out from the dissolution medium, and the absorbance was detected by a UV-visible spectrophotometer (UV-1780, SHIMADZU).

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PMC10891340

We hypothesize that because CCCP treatment of infected cells induces mitophagy and removes damaged cells resulting in a downregulation of ROS levels.

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PMC6684588

Inhibitory activity of ACE-083 was measured in dual-luciferase reporter assays conducted with A204 cells.

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PMC11578343

Sylgard 184 PDMS (Dow Corning) was mixed at a 10:1 w/w ratio of elastomer to curing agent, degassed, poured onto the master, and subsequently cured on a hotplate at 80 °C for 2 h. A slab of PDMS with the embedded microfluidic channel was excised from the master, and inlet and outlet holes were created using a 1 mm biop...

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PMC7553912

TNF-α was also induced by stimulation with OSM in the renal fibroblasts, while the expression of MCP-1 was not affected by OSM.

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PMC10092581

Error bars indicate SD.

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PMC9429973

All patients underwent iPET/iCT (iCT=52 (81.3%); iPET=12 (18.8%)).

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