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OTAR3088
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BioData-CellLine_annotated

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PMC7192625
These differences in topology are reflected also by the network measures reported in Figure 5E (Supplementary Figure S11).
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PMC11538390
In the GWAS of CP, ten SNPs reached genome-wide significance on chromosome 1p36.1, including the lead SNP rs113965554 (P = 2.32 × 10, OR = 2.73) and the previously described etiologic missense variant p.Thr454Met (rs41268753, P = 1.39 × 10, OR = 2.66) in the GRHL3 gene (Table 1).
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PMC9429973
The QoL was assessed using the Pediatric Quality of Life Inventory (PedsQL4.0), which contained 23 items in 4 dimensions (physical, emotional, social, and school functioning).
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PMC11509309
In case of failure to reduce ER stress, the cell then becomes engaged in an apoptotic pathway .
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PMC11482552
Additionally, two complementary international initiatives, VALGENT (VALidation of HPV GENotyping Tests) and VALHUDES (VALidation of HUman papillomavirus assays and collection DEvices for HPV testing on Self-samples and urine samples), have been introduced to evaluate the clinical performance validation of HPV assays on...
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PMC10218459
In addition, individual chemotherapeutics in combination with CPP were applied to the ES cells and the effects on cell growth, cell viability, and apoptosis processes were examined.
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PMC9895440
In later experiments T2, Jurkats, Raji and NA8-Mel cells were cultured in the media described above but replacing the 10% FCS with 2% FCS and 10% of Panexin Basic FCS Replacement (PAN Biotech) which results in identical growth kinetics.
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PMC9429973
Additionally, the quantitative value of SUVmax parameter in the response assessment is almost not studied.
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PMC11463018
m.p.:
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PMC8753818
As well as caspase-3, caspase-7 is an executioner caspase involved in cleaving downstream substrates such as PARP .
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PMC7823217
Similarly, many combinations of synthetic and naturally derived hydrogels (E.g. Gelatin methacryloyl) are being used within bioinks to print robust tissue constructs .
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PMC11285179
Extensive research data indicates that anti-angiogenic tumor therapy exhibits the potential to augment the effectiveness of diverse therapeutic modalities, including chemotherapy, radiotherapy, tyrosine kinase inhibitors (TKIs), and immunotherapy.
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PMC8316344
B PI staining of liver cancer cells as indicated following treating with RSL3 (5 µM, 6 h) or erastin (10 µM, 6 h) with or without DFO (25 µM, 6 h).
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PMC9429973
With a median follow up of 15 months (mos), 5 pts are alive with a median RFS and OS of 6.2 and 7.1 mos respectively (Fig. 1B.
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PMC9479186
We collected a total of 104 paraffin-embedded HCC tissue samples and paired 68 adjacent non-cancerous tissue samples from patients who were admitted to the Zhejiang Cancer Hospital between December 2012 and July 2019.
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PMC11549062
Scar bar 10 μm. (
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PMC11703992
C Dotplots showing characterized metabolic pathways of DDIT4 ± and ARHGAP15 ± cell groups and other cell groups in T cells samples, both color and size indicate the effect size.
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PMC8382973
Sequencing was performed using the Illumina MiSeq system (Illumina MiSeq, USA).
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PMC9429973
Median time from diagnosis to initiation of CAR-T was 15 months.
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PMC5673955
Detection of fluorescence was assessed by plate photometer MultiscanGo (Thermo Scientific Inc.) in the spectra excitation and emission 490 nmol/L and 525 nmol/L respectively.
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PMC11748335
It reflects the loss of H3K9me3 in a tumor-gain LOCK region within an L-PMD While observing the expected changes in DNA methylation levels in the three groups of LOCKs in tumor cell lines, we also noticed that the tumor-gain LOCKs (i.e., non-LOCK regions in normal cell lines) exhibited low DNA methylation levels, even ...
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PMC11568601
Scale bar = 50 μm.
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PMC11575040
Metformin is an oral antihyperglycemic agent that increases glucose tolerance in patients with type 2 diabetes mellitus (DM) by reducing their basal and postprandial plasma glucose levels.
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PMC11738017
The TCE cytotoxicity assay with or without GSI.
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PMC8708099
The pathogenesis of intestinal inflammation is a complex process involving alterations in intestinal barrier function and food intolerances, leading to activation of the innate immune system.
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PMC10094712
In this work, for the first time, studies of the molecular mechanisms of regulation of the cytotoxic effect of this protein on human glioblastoma cells were carried out.
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PMC11676169
When comparing the overlap of modulated transcripts between etoposide-treated control and BCAT1-depleted cells, we found 153 transcripts commonly upregulated in both groups, while 322 and 450 transcripts were uniquely upregulated in BCAT1-depleted and control cells, respectively (Figure 1C).
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PMC11052306
60 nm) with 9-G0-[Au5][AuCl4]5 in water, as shown both by DLS and TEM images.
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PMC9429973
221 pts were available for MRD analysis with a median number of 4 (0-13) and 5 (0-23) samples from BM and PB, respectively.
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PMC10094712
Differences were considered significant at p < 0.05. ***
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PMC11740508
PDX received the identical talazoparib dose, and ½ dose of decitabine.
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PMC11394730
Moreover, quercetin can trigger protective autophagy in breast and gastric cancer cells by inactivating the Akt-mTOR pathway and HIF-1α signaling .
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PMC11357960
Recently, many biomarkers, such as single-cell RNA sequencing or non-targeted metabolomics from tumor samples, and immune infiltration in the tumor microenvironment, had been shown to be potentially useful to predict therapeutic response in lung cancer patients treated with anti-PD-1 immunotherapy (57, 58).
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PMC11577421
Notably, NP_BSA+/PCX was significantly more potent, with an IC50 of 51 pM compared to 192 pM for NP_BSA/PCX.
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PMC11548041
Cholesterol modified versions of these aptamers retained their EpCAM recognition and binding abilities and were successfully incorporated into the membrane of MNVs.
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PMC10125312
To elucidate this pivotal aspect, we present a systematic study of diseased and nondiseased cells from different tissues to evaluate cytotoxicity, uptake of gold nanorods (AuNRs), and viability after PPTT.
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PMC11266100
The investigation revealed that the composition of the electroporation buffer significantly influences the efficacy of GET in CHO-K1 cell line.
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PMC11216402
For gkm-SVM training, peaks were called by MACS2 (Zhang et al. 2008).
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PMC11012012
All analyzed Burkitt lymphoma cell lines (Raji, Daudi, Ramos, and Namalwa) were SLAMF4/CD244-negative .
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PMC11534377
Across 10,013 genes, there was a significant shift in expression (average p-value = 0.0029), indicating a potent cellular response.
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PMC11514418
Consequently, many patients with pancreatic cancer miss the opportunity for surgery, leading to high recurrence and metastasis rates even after radical surgery.
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PMC11742047
The blue edge means fatty acids deleted, the orange edge means fatty acids modified, the green edge means head groups deleted, red edge means head groups modified.
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PMC11583010
We also anticipate from the observed HNSTD in NHP that the recommended therapeutic dose in humans will be sufficient to overcome the sink effect of normal nectin-4 expression while ensuring complete tumor penetration to maximize the cytotoxic effects of exatecan.
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PMC11388384
This design is conceptually equivalent to a three-dimensional simulation, where the third spatial dimension is small relative to the diffusion rate, as is likely true at the interface between two mesenchymal cells.
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PMC9429973
63% of patients were transplanted in 1 CR, 35% in ≥2 CR, and 2% after primary induction failure.
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PMC9920575
Cisplatin induced caspase-3 activation in both HeLa and HaCaT cells (12.7% and 16.6%, respectively) while exposure to the S. chinantlense extract induced the activation of caspase-3 in the HeLa cancer cell line but not in the HaCat cell line (30.3% and 6.3%, respectively) (Figure 6).
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PMC11429241
Cell cultures were observed and imaged every day using an OPTIKA ITALI IM-5 series microscope, while image analysis was performed by employing Fiji, an image processing package.
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PMC7338939
The sequencing results revealed that BRAF gene had a T to A transversion at nucleotide position (BRAF c.1799T>A) or amino acid position 600 just in A375, which resulted in an amino acid substitution from valine to glutamic acid at codon 600 (V600E) (Supplementary Figure 1A).
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PMC11352311
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted using the Database for Annotation, Visualization, and Integrated Discovery (DAVID) (https://david.ncifcrf.gov/) (accessed on 11 August 2024).
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PMC9429973
The proportion of older patients receiving HCT, autologous and allogeneic, increased from 5.5% and 1.7% in 2009 to 17.7% and 10.5% in 2018, respectively.
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PMC11806818
In addition, two multifunctional Ti3C2@Au@Pt nanozymes were prepared based on Vascular endothelial growth factor 165 (VEGF165) aptamer and EpCAM aptamer.
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PMC8557138
Though considerable heterogeneity exists in ECs, the most frequently used ECs for in vitro assays only include HUVECs and (Jaffe et al. 1973) HDMECs isolated from human umbilical veins, and foreskin tissue, respectively (Goodwin 2007).
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PMC8633974
Culture supernatants were assayed for RT activity by surveying for H-thymidine incorporation (3H-TTP; Perkin Elmer #NET221A001MC).
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PMC11476837
We have observed that neither ML-385 nor doxorubicin treatment had an influence on NRF2 protein level in HL-60/DR cells.
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PMC8916024
The colonization of the gut flora of aquatic animals is a complex process affected by many factors such as the sediment, water environment, and bait (Romero & Navarrete, 2006).
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PMC9583612
This value was selected to isolate concentration spikes that were notably higher than background readings.
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PMC9429973
We can use NOTCH1 gene mutation as an additional factor in predicting the course of CLL.
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PMC11487720
When cells were treated with UV/cold shock, α-tubulin was downregulated and depolymerized during continuous culture at 4 °C.
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PMC7090062
This finding showed that beclin-1 was successfully silenced.
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PMC11679033
Typical appearances of binucleated cells with these features observed on microscope slides are displayed in Figure 6.
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PMC9429973
The study included 93 patients with acute leukemias, 51 patients with non-Hodgkin’s lymphoma, 30 patients with chronic lymphocytic leukemia and 18 patients with multiple myeloma.
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PMC11180402
Finally, our recent studies showed that ISO inhibits the stem cell-like properties and invasion of BC by attenuating CD44 expression .
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PMC10748106
These iridoids had a variable number of hydrogen bond donors and acceptors, ranging from 1 to 4, and 3 to 5, respectively.
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PMC4369959
6-Gingerol modulates NF-κB, STAT3, Rb, MAPK, PI3K, Akt, ERK, cIAP1, cyclin A, Cdk, cathepsin D, and caspase-3/7.
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PMC11703992
The commonly upregulated DEGs were identified using “FindMarkers”.
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PMC11611077
Patch pipettes had a resistance of 2–5 MΩ when filled with an internal solution composed of 140 mM KCl, 3.5 mM MgCl2, 5 M EGTA, 5 mM HEPES, and 0.1 mM CaCl2, adjusted to pH 7.2.
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PMC9429973
Additive/synergistic effects of combining STP938 with two different ATR inhibitors were assessed on cell line proliferation and enumerated by Bliss score (Synergyfinder 2.0).
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PMC11285179
In this study, we identified CCL28 as another crucial molecular target for vascular normalization in lung adenocarcinoma.
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PMC9429973
Additional studies are essential to elucidate the genotype-phenotype correlation.
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PMC9031474
The following part aims to give a comparative overview of accomplished results regarding the mode of action of drimane and coloratane sesquiterpenoids.
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PMC11228511
It is interesting that the nucleoplasmic portion of emerin (an inner NM protein related to LAP2β) forms filamentous structures in vitro (47), but thus far there have been no reports that LAP2β shares that property.
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PMC11615828
Whether variances were equal or not with the F‐test were first determined and then used the unpaired two‐tailed Student's t‐test to calculate P‐values via PRISM 10 software.
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PMC10747139
Schoeller et al. (2023) reported on the synthesis and cytotoxic activity evaluation of bipyridine Ru(II) complexes with halogen-substituted salicylates against breast cancer (MCF-7) and glioma (U-118MG) cell lines using an MTT assay.
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PMC11629192
These effects of OFA in our anti-NMDAR encephalitis patients were similar to other studies about OFA treatment in adult AE.
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PMC10914904
Moreover, this domain has been shown to interact with p62, a protein involved in autophagy .
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PMC11612626
U266 cells were also probed using APC-conjugated anti–human HLA-A2 antibody (BioLegend, 343308) and PE-conjugated HLA-B7 mAb (BB7.1; Invitrogen, 12-5917-42).
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PMC10243817
The mRNA stability assay was performed on ALI-cultured HNECs as previously described with minor modifications (62).
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PMC8633974
Homoscedasticity of data was determined by the Cochran C, Hartley, and Bartlett test.
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PMC11537649
It is reported that evodiamine inhibits the malignant progression of ovarian cancer cells by regulating the Lnc RNA-NEAT1/miR-152-3p/CDK19 axis.
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PMC11240571
PD-L1 expression was evaluated using Western blotting.
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PMC6034753
Marek's disease (MD) is a neoplastic disease of poultry caused by Marek's disease virus (MDV), a highly contagious alphaherpesvirus.
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PMC11612626
RPMI-8226 cells were treated with compound A, and lysates prepared and immunoprecipitated with a W6/32 antibody.
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PMC11453018
Moreover, we demonstrate pharmacological targeting of the EWS::FLI1/P300/CBP axis holds promise as a therapeutic approach for ES.
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PMC9412887
More importantly, the performance of nanomedicines can be improved by a variety of modifications, such as antibodies, peptides and cell membranes, to improve drug bioavailability, change surface charge, improve pharmacokinetic parameters or promote active targeting .
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PMC11301242
Integrating ATAC-seq profiles with WGS data, we detected a significantly higher ATAC-seq signal in the circular amplicons of circular samples, confirming that the ecDNA chromatin landscape is more accessible than chrDNA.
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PMC10852540
Medicinal plants are important not only as therapeutic agents, but also for pharmacological research and drug development.
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PMC10936243
Theme 3: An emphasis on cleanliness and sterility in the cageVeterinarians’ perceptions.
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PMC11502962
(A) GIST882CM group; (B) GIST882CM+WZ811 group.
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PMC11790971
Lastly, the throughput of the lab-built multimodal optical imaging system is lower compared to established high-throughput techniques, such as flow cytometry, which can analyze large numbers of cells at a rapid rate.
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PMC11621565
In our chosen range of concentrations, we noticed a discrete change in neuronal viability and cytotoxicity at the highest concentration in both treatments (32 µg/ml).
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PMC10170482
We showed previously that continuous irradiation of cell with 649 nm HFLP with irradiance of <1 kW/cm leads to mitochondrial damages and subsequent cell death.
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PMC11594074
It has previously been postulated that tumors with high intra-tumoral heterogeneity may cause patients to have poorer clinical prognosis, as it poses favorable conditions for resistance development .
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PMC5600151
In a xenograft mouse model with BALB/c mice bearing OVCAR-3 cells, the mAbK1-PPI-PTX formulation promoted higher tumor growth inhibition, as well as survival rates, when compared to control, free PTX, and PPI-PTX only.
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PMC9429973
AML patients harboring the TP53 gene mutation represent a significant unmet medical need.
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PMC11656380
Relationship between structure and cytotoxicity in Tat-Ram13. (
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PMC11190062
The situation in vivo is however far more complex.
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PMC5941560
BreakDancer identified 6128 deletions, 18 insertions, 183 inversions, 1981 intra-chromosomal translocations, and 113 inter-chromosomal translocations.
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PMC9684669
The genes are considered significant changes when the p-value is < 0.05 and the fold change is > 2-fold. (
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PMC9429973
Aims: To analyze the role of miRNAs involved in HSC self-renewal and stemness pathways (NOTCH, WNT/beta-catenin, HOX, and FLT3) in a pediatric acute lymphoblastic leukemia (ALL) and myeloid acute leukemia (AML) cohort of patients.
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PMC8414691
Alternatively, abnormal numbers of centrosomes can be a consequence of cytokinesis failure that results in the formation of MC.
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