Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC3931643
The detected proteins were then separated on a SDS PAGE gel and transferred to a nitrocellulose membrane and probed with Anti-Biotin, HRP-linked antibody (Cat# 7075, Cell Signaling).
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PMC11413393
RBP: RNA-binding protein; aDMA: asymmetric dimethylation; Me: methyl group.
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PMC10419319
The stained cells were acquired and analyzed using a BD LSRFortessa™ X-20 flow cytometer (BD Biosciences, San Jose, CA, USA) and FlowJo 10.8 (BD Biosciences).
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PMC11277157
Beyond the antiviral-like response, 114 genes were specific to the KD of DJ-1 with enrichment in RNA metabolism and mitochondrial functions.
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PMC10114490
D mRNA level of four differentially expressed genes based on results previously published .
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PMC10048572
The cultures were diluted on the third day by removing part of the cell suspension and adding fresh medium.
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PMC10988808
When the cells grow to 75% alignment, the cells are damaged with the tip of a sterile pipette and the cell debris is removed with PBS washing.
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PMC10198699
Importantly, a cell line is a new kind of object that is created from the tissue sample.
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PMC10798140
s, 8H).
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PMC10443665
It contains sugars such as L-arabinose, L-fucose, D-mannose, D-glucose, D-galactose, and D-xylose (1920).
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PMC9429973
Standard dose (45 or 60 mg/m2 daunorubicin) (SD); 2.
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PMC7192625
This separation between early and late RT regions is maintained when looking at the PP subnetwork (Figure 6C).
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PMC11700247
CD45/CD3/CD8 T-cell tumor infiltration. (
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PMC9429973
Within the last 12 months before SARS-CoV-2 infection, 40 patients (70%) had received treatment for their hematological disease, 17 (30%) were on anti-CD20 maintenance, 12 (21%) on treatment with immuno-chemotherapy (ICT), 6 (11%) on ibrutinib, 3 (5%) on checkpoint inhibitors and 3 (5%) were on chemotherapy only.
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PMC10507284
The KEGG pathway enrichment analysis result between the different TROAP expression cohorts (using c2.cp.kegg.v6.2.symbols.gmt). (
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PMC11657695
D ITGB2 and ITGB3 normalized gene expression in A-673 cell line (N = 4).
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PMC11803149
Additionally, mice transferred with aged TCR-T cells that were transduced with Epas1-expressing vectors showed weight changes comparable to those of the control group ( Supplementary Figure S6 ).
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PMC11779876
In addition, there were two cases in which the major malignant clone completely lacked TRBC expression which is illustrated by a case with a dominant blue clone in Fig. 1b.
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PMC11700247
Graphs show the mean ± SEM.
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PMC11768281
Research subjects included Plasmodium-infected or immunized human and murine models, with the majority assessing Plasmodium falciparum and Plasmodium vivax in humans and P. berghei, P. yoelii, and P. chabaudi in mice.
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PMC11337594
This result indicated that the DNA replication process is indeed altered in TER-treated A375 cells.
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PMC11194678
Right: Quantification of the number of cells with nuclear TFEB localization.
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PMC11680391
We informed the dairy farmer about the purpose and aim of the research project during the initial contact to ensure transparency and to ask for consent.
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PMC11297139
e ChIP assays performed on EWS/FLI1-bound enhancers in ARID1A + WT and ARID1A + ΔDD A673 cell lines using antibodies against IgG, FLI1, H3K27ac, and SMARCC1.
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PMC11794588
Finally, 100% acetic acid was used to elute the column.
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PMC9429973
Further in vivo studies will improve our understanding of MRC2, which could then inform us on novel therapeutic approaches.
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PMC11641532
After washing with TBST, membranes were incubated with a secondary antibody (1:5000, Proteintech, Rosemont, IL, USA) for 1.5 h at room temperature.
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PMC9504875
Construction of ubiquitin mutant (Ub K63) with myc tag at its N-terminus was carried out by a standard PCR mutagenesis method, and cDNA of myc-Ub K63 was inserted into pEF4/Myc-His vector.
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PMC10958426
Analysis of tumor subclones inferred by CNVs showed accumulation of mutations in each tumor subclone along lineage trajectories.
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PMC11190538
Standard drugs, Aspirin and Diclofenac were used as the reference.
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PMC9143157
An amount of 0.1 µM cisplatin was added to A2780/cis cells, and 0.1 µM DOX hydrochloride were added to A2780/ADR cells, respectively.
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PMC10976516
CAFs can impose a major hindrance on the infiltration of OVs in the tumor microenvironment and this elegant combination of OV-directed oncolysis with FBiTE-mediated cytotoxicity against FAP-expressing CAFs might overcome this hindrance on OV function.
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PMC11411131
The Krab-Sec/Luc construct was investigated in neurons as a potential MeHg sensor for future application in sensor vectors in the brain.
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PMC8973085
The reaction mixture was allowed to cool after being refluxed for 3–5 h. Compounds 4a–4h were obtained by filtering off the produced precipitate, drying, and crystallizing it from the proper solvent.
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PMC8494202
GSEA 4.0.
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PMC9429973
In the recent two decades, older patients (>50 years of age) and patients with comorbidities have been able to receive HCT due to the introduction of non-myeloablative conditioning in Denmark in 2001.
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PMC11628904
Following injury, photoconverted nuclei are rapidly lost from burned tissue with only 15% ± 2.5% of cells remaining by 6 hpb (Figure 2C), indicating widespread keratinocyte death over time.
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PMC11359735
The salivary glands of ∼500 P. falciparum infected mosquitoes were lysed using 1% Triton X-100 to yield 4 × 10 sporozoites.
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PMC9479186
Complex I activity (U/mg port) = [δA × V ÷ (ϵ × D) × 10] ÷ (V × Cpr) ÷ T = 1608 × δA ÷ Cpr Abbreviation: V: Total volume of the reaction system; ϵ:NADH molar extinction coefficient = 6.22 × 103 L/mol/cm; D: Cuvette light diameter = 1cm; V: added sample volume, 0.05 ml; T: reaction time = 2 min; Cpr: sample protein conc...
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PMC11806818
As shown in Fig. 7A, to achieve specific detection, EpCAM aptamers for capturing MCF-7 cell exosomes were immobilized on the well plates, while CD63 aptamer sequences were modified in the DFs for DFs to be attached to the exosomes.
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PMC10944868
Likewise, the structures of the different ligands to be interacted with protein and the ligand initially present in the complex, colchicine, were prepared.
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PMC11657744
The x-axis represents the DNA content, and the y-axis represents the number of cells.
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PMC8097906
The VSM plant sample was extracted in MeOH and 50 mg of its dry sample was dissolved in 1 ml DMSO to a 50 mg/ml stock solution.
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PMC11650848
Meth.
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PMC9895440
Data were collected using the BD FACS Diva Software version 7 (for Fotessa), Beckmann Culture CytExpert, or SpectraFlow (for Aurora) and further analyzed with FlowJo v10.1.6 (Tree Star Inc.) and GraphPad Prism v8 (GraphPad Software Inc.).
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PMC7338939
Notch inhibition enhanced apoptosis in treated cells 48 h after treatment, but its rate was reduced 96 h after treatment. (
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PMC6163708
We have chosen two GANT61-sensitive tumors cell lines, SK-MEL-3 (see Figure 2) and SK-MEL-5 (see Figure S1).
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PMC9429973
Until such evidence becomes available, our results are highly important for informed decision making in everyday clinical practice H. C. Lee, K. Ramasamy, M. Macro, F. E. Davies, R. Abonour, F. van Rhee, V. T. Hungria, N. Puig, K. Ren, J. Silar, V. Enwemadu, D. Cherepanov, D. M. Stull, X. Leleu MD Anderson Cancer Cente...
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PMC5833712
Pellets were washed with PBS, fixed in ice-cold 75% ethanol at 4 °C, treated with 100 mg/ml RNAse A for 1 h at 37 °C, stained with 25 μg/ml propidium iodide and finally analyzed by using a flow cytometer FACS (Becton Dickinson, San Jose, CA, USA) and Modfit software (Verity Software House, Topsham, ME, USA).
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PMC11486946
The average distributions over the cells are shown at the bottom.
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PMC4395774
In both PGK.PRF and PRF.PRF reconstituted mice, the reconstitution of NK cell cytotoxicity was 40% of that seen in WT cells (Figure 4a), whereas the recovery of CD8 T cell cytotoxicity (redirected killing of P815 cells conjugated with anti-CD3 antibody) was similar to that seen in WT cells (Figure 4b).
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PMC11696659
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Life Length SL reports financial support was provided by European Commission.
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PMC2193049
Construct I (Fig. 1) was obtained by PCR amplification of a fragment encoding the tumor antigen MAGE-3 (a gift from T. Boon, Ludwig Institute for Cancer Research, Brussels, Belgium).
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PMC11755624
Specifically, the molecule was found to be downregulated and upregulated in leukocytes and skin from psoriasis patients, respectively .
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PMC11680049
The test tubes were placed in a light room on shelves under white linear fluorescent lamps, with an intensity of 150 µmol/m·s, and cultivated at a temperature of 23 ± 1 °C with a 16 h photoperiod.
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PMC9429973
The majority of patients (67,0%) was more or less willing to participate in a clinical trial when offered (24% previously or actively participated in a clinical trial).
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PMC11585254
Receptor desensitization experiments using the pGlosensor were performed on HEK293 cells.
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PMC9429973
Results: Participants in our survey reached consensus on 3 of the 4 time-to-event endpoints definitions.
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PMC10999934
Firstly, tissue dissociation results in the loss of spatial information of cells, although the accuracy of identified biomarkers is enhanced by single-cell RNA sequencing; therefore, combining single-cell RNA sequencing with spatial transcriptomics may provide a more comprehensive approach.
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PMC11453378
P.J. Fuller: None.
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PMC9712534
Structure of human TOP2B. (
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PMC9429973
Across all analyses, results suggested FEDR consistently increased the odds/risk of a spleen response compared with NAV+RUX.
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PMC11012313
Each of these individual experiments described above was performed at least three times independently to demonstrate reproducibility.
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PMC9429973
Sabatolimab is a novel immuno-myeloid therapy that binds to TIM-3 on immune cells, facilitating immune activation and phagocytosis of leukemic cells.
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PMC11670407
c Apoptosis levels were assessed via flow cytometry (n = 3).
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PMC8041314
More strikingly, compounds 15, 18, 21, 22, and 26 belong to the structural classes of 1,2,4-oxadiazoles, 1,3,4-thiadiazoles, and thieno[3,2-c]pyridines.
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PMC11792888
In human lung cancer, Androctonus australis venom and its toxic fraction exerted a greater effect against NCI-H358 cancer cells than normal MRC-5 fibroblasts .
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PMC10523483
Together, these results indicated that H1.2 is a binding partner of NRF2 that facilitates nuclear NRF2 accumulation which binds to the GCLC promoter and initiates the consequent GCLC transcription.
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PMC9532503
IDT Codon Optimization Tool for codon usage optimization by manually reassigning codon usage based on the frequency of each codon’s usage in the Cricetulus griseus (Chinese hamster) codon usage table.
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PMC9895440
Source data and exact p-values are provided as a Source Data file.
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PMC9429973
After anthracycline-based chemotherapy, more than 70% of DLBCL patients can get complete response or partial response, but only 50% - 60% of patients can survive for a long time.
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PMC10969097
Unfortunately, due to funding this study never took place.
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PMC11754432
In addition, phosphorylation of ERK was increased following CDDO-Im treatment, along with rescuing the ALOX15B silencing mediated reduction in ERK (Fig. 6E).
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PMC9429973
Image: Summary/Conclusion: Among NDMM pts treated with novel-agent-based induction and undergoing HSC mobilization with CY/GCSF, “on-demand” PLX in case of low CD34 cell count or insufficient HSC yield was a safe and effective rescue strategy, reducing mobilization failure from 16% to 5%.
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PMC11742290
Several gastric cancer studies have indicated relationships between LGR5 expression and chemotherapy resistance.
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PMC7887261
Collectively, these findings suggesting POMC and MLNR, while both functions in multiple cellular processes, might also share their various effects on DNA damage.
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PMC10421378
TG/DTA analysis was used to compare the Tg values.
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PMC10812665
Thereby, the ratio of ROS formation and ETC inhibition may be slightly altered, and our study shows that this may be reflected in a large panel of secondary metabolic consequences, that themselves may again affect mitochondrial function or other cellular reactions.
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PMC9429973
Most patients were treated with plasmapheresis (85%, n=22) and/or corticotherapy (89%, n=23).
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PMC11730311
Antagonizing CGRP actions in migraine patients has proven clinically efficient.
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PMC9429973
Aims: A new comprehensive and integrated approach to wellness Proper diagnostic of disease complication Early detection of disease risk Prevention of disease complication Individualized treatment plans Methods: Retrospective Record Review for all thalassemia patients Treated at King Abdulaziz University Hospital from t...
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PMC9592219
TCGA data showed that these candidate miRNAs had low expression in tumor tissues and high expression in ANT (Figure S4A).
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PMC10631132
The right microenvironment therefore appears to be critical for successful hematopoietic differentiation [53, 55–57].
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PMC11696576
These were PLCL1, PLCL2, GPLD1, and LPL.
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PMC11678841
Altogether, these results suggest that GA may have the potential to modulate key protein kinases associated with the immune response of VECs to C. albicans infection, namely, the stress-activated p38 and pro-survival MAPK-ERK .
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PMC9412887
Positively charged nanomedicines are more likely to be filtered out of blood by spleen, liver and lungs.
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PMC11770199
The overrepresentation analysis was used to estimate the functions of the DEGs.
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PMC9429973
Cmin was found to be similar across various age groups with a median of 1.17 ng/ml, 1.42 ng/ml and 1.46 ng/ml for age group 20-39 years, 40-59 years and ≥ 60 years respectively (range – 0-22.5, p – 0.346).
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PMC11380329
E (da) + E (cb) E (db) Where; CI = combination index E (ca.)
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PMC10040136
Data are means ± SEM (n = 3 in each group) *p < 0.05; **p < 0.01 MSC and IM resistance in GIST cells in vitro.
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PMC11306331
Constructs utilized in this study were inserted in a pHR or pPB vector that included a SFFV or TetOn promoter and WPRE terminator.
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PMC11371627
Abbreviations: CD56 NK, CD56 natural killer cells; CD56 NK, CD56 natural killer cells; cMono, classical monocytes; CSF, cerebrospinal fluid; del, deletion; EDTA, Ethylenediaminetetraacetic acid; Gly, glycine; HLA-DR pos, activated cells; iMono, intermediate monocytes; ncMono, non-classical monocytes; NK, natural killer...
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PMC9429973
MajesTEC-3 opened in October 2021 and is currently enrolling pts.
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PMC9429973
71% of patients with PETEOT (+) presented POD24, in contrast to only 9% of patients with PETEOT (-), p < 0.001.
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PMC11723210
The accuracy of the BPR method was validated using off-axis digital holographic microscopy (DHM) , which serves as the gold standard for QPI.In the DHM experimental system, the wavelength of illumination used is 532 nm.
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PMC11676670
For comparison, we used data on both focal gains and losses as well as on gene copy number alterations (Supplementary Table S1) .
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PMC11609529
IP products were analyzed for TEAD and YM by western blotting.
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PMC10729469
Herein, we evaluated changes in the suppressive function of peripheral Tregs after adoptive transfer of TCRAβ-, polyclonal-, or EV-Tregs to APP/PS1 recipients.
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PMC9545474
H NMR (400 MHz, CDCl3): δ 5.54 (2H, d, J H‐H=6.1 Hz, H3), 5.42 (2H, d, J H‐H=6.2 Hz, H4), 4.46 (6H, m, H11), 4.03 (6H, s, H10), 2.72 (1H, sept, J H‐H=6.9 Hz, H6), 2.19 (3H, s, H1), 1.20 (6H, d, J H‐H=6.9 Hz, H7) ppm.
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PMC11679033
The concentration range was selected with a focus on physiologically relevant concentrations and according to previous experiments on CIT .
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