OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	An age and ELN-risk matched comparison between patients treated with gilteritinib and intensive salvage revealed similar response rates (50% in both groups); median OS was 9.6 months (CI 95% 2.3-16,8) vs. 7 months (CI 95% 5.1-8.9) in gilteritinib and matched controls, respectively (p = 0.869, figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among them the most frequent bleeding events were G2 (4/7) and G4 (2/7), two of them died during the first course of chemotherapy due to gastrointestinal bleeding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	Several studies have demonstrated that 2ME2 exposure promoted ERK1/2 activation in prostate cancer cells and in well-differentiated HK-1 cells, respectively .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Several", "stu...
PMC7022782	Obtained results showed an effective stabilization of ICG; furthermore, color inclusions inside the cells treated with ICG-loaded NPs demonstrated the internalization of NPs with associated ICG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11515150	Nanobody (VHH) is derived from the variable domain of heavy-chain antibodies of.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanobody", "(", "VHH", ")", "is", "derived", "from", "the", ...
PMC11740573	Gram-negative strains were less sensitive to the combination of antibiotics (amoxicillin/clavulanic acid or kanamycin) with calcitriol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gram-negative", "strains", "were", "less", ...
PMC4485786	huCD34 cells (1 × 10 cells in 100 µl prewarmed PBS) were injected in the tail vein of sublethally irradiated (250 cGy) NSG mice.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	OC cells were subjected to ascites fluids at concentrations of 10 %, 20 %, 25 %, 30 %, and 40 %, after which their sensitivity to platinum (RJY13) compounds was examined (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9926039	Opioids seem to interact with the innate immune receptors, such as toll-like receptors (TLRs) and in particular TLR 4 (TLR4) and affect their signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	In biological activity, lncRNAs act as signaling mediators involved in gene activity regulation, protein modification and post-transcriptional regulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "biological", "activity...
PMC8557138	A single cell, tissue, or many connected models are arranged in a microfluidic flow device (Haddrick and Simpson 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC9429973	Results: Sixteen ITP patients were assigned to the group with sublytic C5b-9 assembly on MSC membranes (MSC-ITP-C+ group), while the remaining 14 patients were assigned to the group without complement activation (MSC-ITP-C- group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	Cell suspensions were filtered using a cell strainer (70 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "suspensions", "were", "filtered", "using", "a", "cell", "strainer", "(",...
PMC8193813	Calculation of NOx emissions uses the appropriate F factor, a value that relates the required combustion gas volume to fuel energy input, as described in US EPA Method 19 (2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	Here, cisplatin was conjugated to half-generation anionic PAMAM dendrimers in mono- and bidentate forms, and their biological effects were assessed in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Twelve patients (19.7%) discontinued PVD treatment, mainly due to toxicity and patients’ intention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twelve", "patients", "(", "19.7", "%",...
PMC9884169	All data were statistically analyzed using GraphPad Prism 7.0 (GraphPad 8.0, Inc., San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data"...
PMC11612508	Drug loading efficiency (A) Swelling characteristics (B) and Drug release of magnetic microspheres at various magnetic frequencies (C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10823017	The treatment group of BYL combined with ICA-1 exhibited greater caspase cleavage and PARP cleavage, indicating that this treatment group resulted in the highest level of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	After that he was admitted to the hospital with SARS COV2 –associated pneumoniae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", "he", "was", "admitted", "to", "the", "hospital", "wi...
PMC10587429	We showed evidence that the CD47 blockade alone had statistically significant but limited efficacy in controlling ES development ( Figure 4 ) which is consistent with previous clinical trial results that CD47 blockade alone is not sufficient to control disease development in solid tumors (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10723784	For example, CBD alone at 30 μM induced approximately 90% cytotoxicity in cells after 24 h contact time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", ...
PMC11648299	Standardized incidence ratio for keratinocyte cancers was 2.9 (95% CI, 2.4–3.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Standardized", "incidence", "ratio", "for", "keratinocyte", "cancers", ...
PMC11357960	The risk score of patient was defined as 2, if the percentage change in mRNA level of SUMO machinery components in PBMC was greater than 100 times or less than -50~-100 times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	We focused on the tibialis anterior (TA) muscle in these experiments because its weakness in certain diseases impairs ankle dorsiflexion and thereby restricts patient mobility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10907726	B–C) Wound healing and transwell were used to assess the potential of DATS and 3-MA on migrative and invasive abilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ...
PMC11536589	The efficiency of the expression was assessed by western blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "efficiency", "of", "the", "expression", "was", "assessed", "by", "western", "blot", ...
PMC11777207	We found decreased DC migration in both Pdl1 and Pdl1 mice (Fig. 3, A and B, and fig. S4C) by both number and frequency of cDC1s (Fig. 3, B to D) and cDC2s (Fig. 3, E to F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791432	In the CGGA_325 cohort, ANXA1 showed prognostic value in Glioma and LGG: Glioma (Fig. 2D n = 313, HR=1.436, P < 0.001), LGG (Fig. 2E n = 172, HR=1.424, P < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	This family caregiver peer to peer intervention has the potential to be a new model of support incorporated in the clinical setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "fami...
PMC11726848	Automated solutions were used to analyze the number of DNA plumes (tails) obtained as a result of the DNA comet procedure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Automat...
PMC11361748	n = 3 mice.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "mice", "." ] } ]
PMC11252553	treated with Taurine (100 µg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "treated", "with", "Taurine", "(", "100", "µg", "." ] } ]
PMC3730428	All experiments were carried out with an isotype control antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "carried", "out", "with", "an", "isotype", "control", "antibody", ...
PMC10040136	MSC are identified by their positive response to CD73 or CD90 fluorescent antibodies (as illustrated in Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MSC", "are", "identified", ...
PMC11721277	According to a proposed mechanism, the tested chlorin is internalized by the cell and undergoes cellular metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "a", "proposed", "me...
PMC7553912	To speculate the roles of OSM in the pathogenesis of kidney stone disease, we first elucidated the expressions of OSM and OSMRβ in the kidney of glyoxylate (GOx)-injected wild-type (WT) mice, a mouse model of renal crystal formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8097906	Mean ± SD, n = 6–8, * P < 0.001, P < 0.01, * P < 0.05, significantly different compared to vehicle control, unpaired t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Keratinocytes transfected with ALOX15B siRNA for 72 h alone (A–D) or followed by 30 min pre-treatment with 2 µM PD168393 or vehicle (DMSO), then combined with cocktail treatment of 50 ng/ml IL-17A, TNFα and 10 ng/ml IFNγ for 30 min (E, F) or IFNγ alone or 6 h (F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	The animal study was approved by Animal Care Committee, University of Ottawa.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animal", "study", "was", "approved", "by", "Animal", "Care", "...
PMC11727145	Collagen IV, also found in the skin basement membrane, contributes to the structure and stability of this membrane .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collagen", "IV", ",", ...
PMC9429973	An additive effect of dual therapy against monotherapy was not observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "additive", "effect", "of", "dual", "therapy", "against", "monotherapy", "was", ...
PMC9429973	Image: Summary/Conclusion: Platelet dysfunction disorders are emerging extraintestinal manifestations of IBD and are associated with worse hospitalization outcomes in this patient population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5854676	In the final investigation, superficial cell viability loss of approximately 14% was observed in the cell line labelled with 250 µg/ml MgO dispersed in dark conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461833	ns, p > 0.05; , p < 0.05; , p < 0.01; , p < 0.001; **, p < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	Construction of a long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) competing endogenous RNA (ceRNA) network. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Construction", "of", "a", ...
PMC11240571	These findings suggest that exosomes containing PD-L1 inhibited T cell activation (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "exosomes", "containing", ...
PMC11770130	If Ntsr2 AKO mice on pair feeding presented comparable or even lower body weight than the control mice, it suggested that the change in food intake was the main reason for the differences in body weight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10674574	pharmaceutics-15-02523-t003_Table 3Table 3List of commonly used Caco-2 cell lines in permeability studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pharmaceutics-15", "-", "02523-t003_Table", "3Table", "3List", "of"...
PMC11281366	Since the packaging of CD59 is not an exclusive property of HIV-1 as it has also been shown in other enveloped viruses , namely human T lymphotropic virus type-1 (HTLV-1), human cytomegalovirus (HCMV) and hepatitis virus type C (HCV), it would be interesting to assess whether these viruses promote CD59 packaging by dow...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756937	In this work, we compared the two commonly used non-integrating reprogramming methods—the episomal and SeV methods (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11770130	Various assays were performed during the treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "assays", "were", "performed", "during", "the", "treatment", "." ] } ]
PMC11291490	Two other groups of ducks were intramuscularly injected with either the vaccine pVAX-prM-E or pVAX-prM-E-dusCD40L at a dose of 200 μg in 0.5 mL of PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9841531	This led to rather diverse assay setups with a minor number of independent confirmatory studies to determine functional compound bioactivities, limiting the overall comparability of data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twelve (92%) patients had at least one other coexisting mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twelve", "(", "92", "%", ")", "patients", "had", "at", "least", ...
PMC11190538	The size of lipid vesicles was observed to be affected by the manner of production .Table 7Characteristics of C-PC-loaded nanophytosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "size", "of", "l...
PMC11718817	As for CTLs, tracking analysis demonstrated the high mobility of these infiltrating CD206 macrophages within the tumor spheroid (Figure 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC9275501	Additionally, natural active ingredients can also be coupled with chemotherapy drugs through disulfide bonds to form redox-sensitive carrier-free nano-system to achieve the controlled release of drugs in tumor-specific microenvironment, such as CPT and arabinoside (Ara-C) (He et al., 2017), CPT and GEM (Hou et al., 201...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	All pts experienced an improvement in their white blood cell count.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "pts", "experienced", "an", "improvement", "in", "their", "white", "blood", "ce...
PMC11643361	Continued research focusing on their structural diversity, metal coordination properties, and biological interactions could pave the way for the development of highly potent and selective anticancer agents, positioning scorpionate complexes as promising candidates in next-generation therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	The results showed that both co-expression groups resulted in increased LDH release from A375 cells and the release of LDH in both groups was effectively alleviated by the caspase inhibitor Z-VAD-fmk (Fig. 6E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Notably, CD19.28.40z CAR-T cells sustained greater proliferation after repetitive weekly stimulation without influencing T-cell fate and exhaustion (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",...
PMC11727000	To examine the functional implication of the interaction between USP44 and BRCA2, we made use of Usp44-null mouse embryonic fibroblasts (MEFs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11628309	Each of these models offers unique advantages and disadvantages, enabling the study of PD from diverse perspectives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "of", "these", "models", "offer...
PMC10988808	However, it may also have different regulatory mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "may", "also", "have", "different", "regulatory", "mechanisms", "." ] } ]
PMC9895440	Representative of n = 3 experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "of", "n", "=", "3", "experiments", "." ] } ]
PMC11367939	Recent studies have suggested the presynaptic localization of ATG9A in neurons [5–8].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "suggested", "the", "presynaptic", "locali...
PMC11527437	Treatment with T cells genetically engineered to express tumor-reactive T cell receptors (TCRs), known as TCR-gene therapy (TCR-T), is a promising immunotherapeutic approach for patients with cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11596967	The net charges of the peptides varied from −3.9 to +2, with Ddes-P4 exhibiting the highest positive charge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "net", "charges", ...
PMC11672881	An increase in reactive oxygen species (ROS) is typical in mitochondria-related apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "increase", "in", "reactive", "oxygen", "species", "(", "RO...
PMC10758402	Supernatants were pelleted at 25,000 RPM for 2 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supernatants", "were", "pelleted", "at", "25,000", "RPM", "for", "2", "hours", "." ] } ]
PMC11422497	Its mechanism of action is also being explored in depth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "mechanism", "of", "action", "is", "also", "being", "explored", "in", "depth", "." ...
PMC9429973	The adverse event rates for CRS and NE of any grade were 32.70% (p<0.01) and 47.70% (p<0.001) lower, respectively, in patients infused with tisa-cel compared to those infused with axi-cel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11549612	Group comparisons were carried out using independent sample t-tests, while Pearson correlation analysis was used to explore relationships between groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Group", "comparisons", ...
PMC11638288	The other putative ligand-binding site resembles the HLA-binding site on killer Ig-related receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "putative", "ligand-binding", "site", "resembles", "the", "H...
PMC7987994	This could also lead to discrepancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "could", "also", "lead", "to", "discrepancies", "." ] } ]
PMC5925824	Each data point is the average of two replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "data", "point", "is", "the", "average", "of", "two", "replicates", "." ] } ]
PMC11562028	Subsequently, 110 μL of the reagent was added to each well and the plates were incubated in a 37 °C incubator for 45 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10729469	Initially to evaluate this, we assessed the distribution of total Tregs (CD4+ CD25+ FoxP3+) by flow cytometry (Fig. 4A) in the spleen, lymph nodes, blood, and brain of WT mice, untreated APP/PS1 mice, or APP/PS1 mice recipients treated with TCRAβ-, polyclonal-, or EV-Treg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11539788	Further experiments indicated that RNF19A promoted cell proliferation and inhibited apoptosis in NCSCL by inducing the ubiquitination-mediated degradation of p53.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "experiments", "in...
PMC11746948	The beads and loading controls were mixed with SDS loading buffer and incubated at 95 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "beads", "and", ...
PMC11627133	We demonstrate the effectiveness of our approach in super‐resolution microscopy in secondary mammalian cell lines and primary neurons by RhoBAST‐PAINT, an SMLM protein imaging technique that leverages the transient binding of the fluorogenic rhodamine dye SpyRho to RhoBAST.In single‐molecule localization microscopy (SM...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the multivariable analysis that included age (>60 vs. <60), stage (localized vs. advanced), IPS (<2 vs. >2), extranodal areas, bulky disease and PET3 result, only age and PET3 result had significant impact in PFS (p=0.046 and p=0,001 respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	CXCL7 can be secreted by MSCs, thereby stimulating MM cells to produce a significant amount of MMP13, which constitutes a crucial means for activating the osteoclast signaling pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315	It is one of the first published reports about the inhibitory properties of Cinnamaldehyde in cancer cells in HL-60 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "It", "is", "one", ...
PMC11748363	The reason for the absence of antibacterial activity in the current series is unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reason", "for", "the", "absence", "of", "antibacterial", ...
PMC11269933	After 36 h, the cells were lysed using a lysis buffer supplemented with protease and phosphatase inhibitors (Beyotime Biotechnology, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11774112	Targeting these mutant genes through gene therapy is an effective method for treating MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeting", "these", "mutant", "genes", "through", "gene", "therapy", ...
PMC9046263	Integrated analyses from The Cancer Genome Atlas demonstrate that HML-6 envelope transcript, ERVK3-1, is a negative prognosticator in glioblastoma patients. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11343332	Apoptosis, also known as programmed cell death, is distinguished by DNA fragmentation, cell shrinkage, chromatin condensation, and the activation of certain enzymes known as caspases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	In addition, the decrease in NAD+ concentration may also result from excessive substrate consumption, e.g., during inadequate metabolic processes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC8984067	In vitro experiments showed that the platform has good biosafety, targeting, and PDT tumor treatment effects under the action of NIR light (980 nm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	However, it was not possible to achieve satisfactory yields of the target carboxylic acid in any case due to the occurrence of adverse reactions involving chlorin oxidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	The experimental data were expressed as means ± standard deviations ().	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "experimental", "data", "were", "expressed", "as", "means", "±", "standard...
PMC10955424	Multiplex ELISA kit (Thermo Fisher Scientific, Paisley, UK) designed to detect presence of enriched cytokines (IL-1α, IL-1β, IL-5, IL-6, IL-8, IL-10, IL-13, IL-22, G-CSF, INF-γ, TNFα, RANTES (CCL5), leptin and MCP-1 (CCL2) was used in 3 ascites groups, according to their ability to induce chemoresistance in A2780cisR c...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Lymphoma cell lines were injected subcutaneously, mAbs were administered i.p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lymphoma", "cell", "lines", "were", "injected", "subcutaneously", ",", "mAbs", "were", ...
PMC9847912	As with other culture-based methods, the IC50 values obtained in our experiments are dependent on the specific assay conditions and cell types used to measure inhibitor susceptibility, and may not precisely reflect the inhibitory potential of GSK232 in various physiological compartments in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Due to both a shortage of carmustine in the past decade and to reduce its pulmonary toxicity, this agent has been replaced in several centers by thiotepa (TEAM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	Here we present evidence that SD4 and GluA1 or GluA2 AMPARs bi-directionally increase the cluster size of each other in heterologous cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we",...
PMC11765988	It may be assumed that SLRs have a known association, and limited clinical sequelae and sarcoidosis, affecting pathologically and functionally several organs, present the more generalized form of this heterogeneous spectrum, while the exact antigen causing the granuloma formation remains largely unknown .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

An age and ELN-risk matched comparison between patients treated with gilteritinib and intensive salvage revealed similar response rates (50% in both groups); median OS was 9.6 months (CI 95% 2.3-16,8) vs. 7 months (CI 95% 5.1-8.9) in gilteritinib and matched controls, respectively (p = 0.869, figure 1C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Among them the most frequent bleeding events were G2 (4/7) and G4 (2/7), two of them died during the first course of chemotherapy due to gastrointestinal bleeding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8839885

Several studies have demonstrated that 2ME2 exposure promoted ERK1/2 activation in prostate cancer cells and in well-differentiated HK-1 cells, respectively .

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PMC7022782

Obtained results showed an effective stabilization of ICG; furthermore, color inclusions inside the cells treated with ICG-loaded NPs demonstrated the internalization of NPs with associated ICG.

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PMC11515150

Nanobody (VHH) is derived from the variable domain of heavy-chain antibodies of.

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PMC11740573

Gram-negative strains were less sensitive to the combination of antibiotics (amoxicillin/clavulanic acid or kanamycin) with calcitriol.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gram-negative", "strains", "were", "less", ...

PMC4485786

huCD34 cells (1 × 10 cells in 100 µl prewarmed PBS) were injected in the tail vein of sublethally irradiated (250 cGy) NSG mice.

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PMC10955424

OC cells were subjected to ascites fluids at concentrations of 10 %, 20 %, 25 %, 30 %, and 40 %, after which their sensitivity to platinum (RJY13) compounds was examined (Fig. 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9926039

Opioids seem to interact with the innate immune receptors, such as toll-like receptors (TLRs) and in particular TLR 4 (TLR4) and affect their signaling pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11088135

In biological activity, lncRNAs act as signaling mediators involved in gene activity regulation, protein modification and post-transcriptional regulation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "biological", "activity...

PMC8557138

A single cell, tissue, or many connected models are arranged in a microfluidic flow device (Haddrick and Simpson 2019).

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PMC9429973

Results: Sixteen ITP patients were assigned to the group with sublytic C5b-9 assembly on MSC membranes (MSC-ITP-C+ group), while the remaining 14 patients were assigned to the group without complement activation (MSC-ITP-C- group).

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PMC9895440

Cell suspensions were filtered using a cell strainer (70 μm).

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PMC8193813

Calculation of NOx emissions uses the appropriate F factor, a value that relates the required combustion gas volume to fuel energy input, as described in US EPA Method 19 (2017).

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PMC9960565

Here, cisplatin was conjugated to half-generation anionic PAMAM dendrimers in mono- and bidentate forms, and their biological effects were assessed in vitro.

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PMC9429973

Twelve patients (19.7%) discontinued PVD treatment, mainly due to toxicity and patients’ intention.

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PMC9884169

All data were statistically analyzed using GraphPad Prism 7.0 (GraphPad 8.0, Inc., San Diego, CA, USA).

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PMC11612508

Drug loading efficiency (A) Swelling characteristics (B) and Drug release of magnetic microspheres at various magnetic frequencies (C).

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PMC10823017

The treatment group of BYL combined with ICA-1 exhibited greater caspase cleavage and PARP cleavage, indicating that this treatment group resulted in the highest level of apoptosis.

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PMC9429973

After that he was admitted to the hospital with SARS COV2 –associated pneumoniae.

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PMC10587429

We showed evidence that the CD47 blockade alone had statistically significant but limited efficacy in controlling ES development ( Figure 4 ) which is consistent with previous clinical trial results that CD47 blockade alone is not sufficient to control disease development in solid tumors (30).

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PMC10723784

For example, CBD alone at 30 μM induced approximately 90% cytotoxicity in cells after 24 h contact time.

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PMC11648299

Standardized incidence ratio for keratinocyte cancers was 2.9 (95% CI, 2.4–3.3.

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PMC11357960

The risk score of patient was defined as 2, if the percentage change in mRNA level of SUMO machinery components in PBMC was greater than 100 times or less than -50~-100 times.

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PMC6684588

We focused on the tibialis anterior (TA) muscle in these experiments because its weakness in certain diseases impairs ankle dorsiflexion and thereby restricts patient mobility.

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PMC10907726

B–C) Wound healing and transwell were used to assess the potential of DATS and 3-MA on migrative and invasive abilities.

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PMC11536589

The efficiency of the expression was assessed by western blot.

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PMC11777207

We found decreased DC migration in both Pdl1 and Pdl1 mice (Fig. 3, A and B, and fig. S4C) by both number and frequency of cDC1s (Fig. 3, B to D) and cDC2s (Fig. 3, E to F).

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PMC11791432

In the CGGA_325 cohort, ANXA1 showed prognostic value in Glioma and LGG: Glioma (Fig. 2D n = 313, HR=1.436, P < 0.001), LGG (Fig. 2E n = 172, HR=1.424, P < 0.001).

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PMC9429973

This family caregiver peer to peer intervention has the potential to be a new model of support incorporated in the clinical setting.

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PMC11726848

Automated solutions were used to analyze the number of DNA plumes (tails) obtained as a result of the DNA comet procedure.

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PMC11361748

n = 3 mice.

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PMC11252553

treated with Taurine (100 µg.

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PMC3730428

All experiments were carried out with an isotype control antibody.

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PMC10040136

MSC are identified by their positive response to CD73 or CD90 fluorescent antibodies (as illustrated in Fig. 1A).

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PMC11721277

According to a proposed mechanism, the tested chlorin is internalized by the cell and undergoes cellular metabolism.

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PMC7553912

To speculate the roles of OSM in the pathogenesis of kidney stone disease, we first elucidated the expressions of OSM and OSMRβ in the kidney of glyoxylate (GOx)-injected wild-type (WT) mice, a mouse model of renal crystal formation.

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PMC8097906

Mean ± SD, n = 6–8, *** P < 0.001, ** P < 0.01, * P < 0.05, significantly different compared to vehicle control, unpaired t-test.

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PMC11754432

Keratinocytes transfected with ALOX15B siRNA for 72 h alone (A–D) or followed by 30 min pre-treatment with 2 µM PD168393 or vehicle (DMSO), then combined with cocktail treatment of 50 ng/ml IL-17A, TNFα and 10 ng/ml IFNγ for 30 min (E, F) or IFNγ alone or 6 h (F).

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PMC10758402

The animal study was approved by Animal Care Committee, University of Ottawa.

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PMC11727145

Collagen IV, also found in the skin basement membrane, contributes to the structure and stability of this membrane .

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PMC9429973

An additive effect of dual therapy against monotherapy was not observed.

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PMC9429973

Image: Summary/Conclusion: Platelet dysfunction disorders are emerging extraintestinal manifestations of IBD and are associated with worse hospitalization outcomes in this patient population.

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PMC5854676

In the final investigation, superficial cell viability loss of approximately 14% was observed in the cell line labelled with 250 µg/ml MgO dispersed in dark conditions.

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PMC11461833

ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

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PMC10933092

Construction of a long noncoding RNA (lncRNA)-microRNA (miRNA)-messenger RNA (mRNA) competing endogenous RNA (ceRNA) network. (

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PMC11240571

These findings suggest that exosomes containing PD-L1 inhibited T cell activation (Figure 2).

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PMC11770130

If Ntsr2 AKO mice on pair feeding presented comparable or even lower body weight than the control mice, it suggested that the change in food intake was the main reason for the differences in body weight.

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PMC10674574

pharmaceutics-15-02523-t003_Table 3Table 3List of commonly used Caco-2 cell lines in permeability studies.

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PMC11281366

Since the packaging of CD59 is not an exclusive property of HIV-1 as it has also been shown in other enveloped viruses , namely human T lymphotropic virus type-1 (HTLV-1), human cytomegalovirus (HCMV) and hepatitis virus type C (HCV), it would be interesting to assess whether these viruses promote CD59 packaging by dow...

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PMC11756937

In this work, we compared the two commonly used non-integrating reprogramming methods—the episomal and SeV methods (Figure 2).

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PMC11770130

Various assays were performed during the treatment.

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PMC11291490

Two other groups of ducks were intramuscularly injected with either the vaccine pVAX-prM-E or pVAX-prM-E-dusCD40L at a dose of 200 μg in 0.5 mL of PBS.

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PMC9841531

This led to rather diverse assay setups with a minor number of independent confirmatory studies to determine functional compound bioactivities, limiting the overall comparability of data.

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PMC9429973

Twelve (92%) patients had at least one other coexisting mutation.

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PMC11190538

The size of lipid vesicles was observed to be affected by the manner of production .Table 7Characteristics of C-PC-loaded nanophytosomes.

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PMC11718817

As for CTLs, tracking analysis demonstrated the high mobility of these infiltrating CD206 macrophages within the tumor spheroid (Figure 1D).

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PMC9275501

Additionally, natural active ingredients can also be coupled with chemotherapy drugs through disulfide bonds to form redox-sensitive carrier-free nano-system to achieve the controlled release of drugs in tumor-specific microenvironment, such as CPT and arabinoside (Ara-C) (He et al., 2017), CPT and GEM (Hou et al., 201...

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PMC9429973

All pts experienced an improvement in their white blood cell count.

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PMC11643361

Continued research focusing on their structural diversity, metal coordination properties, and biological interactions could pave the way for the development of highly potent and selective anticancer agents, positioning scorpionate complexes as promising candidates in next-generation therapeutic strategies.

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PMC11337594

The results showed that both co-expression groups resulted in increased LDH release from A375 cells and the release of LDH in both groups was effectively alleviated by the caspase inhibitor Z-VAD-fmk (Fig. 6E).

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PMC9429973

Notably, CD19.28.40z CAR-T cells sustained greater proliferation after repetitive weekly stimulation without influencing T-cell fate and exhaustion (Figure 2).

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PMC11727000

To examine the functional implication of the interaction between USP44 and BRCA2, we made use of Usp44-null mouse embryonic fibroblasts (MEFs) .

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PMC11628309

Each of these models offers unique advantages and disadvantages, enabling the study of PD from diverse perspectives.

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PMC10988808

However, it may also have different regulatory mechanisms.

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PMC9895440

Representative of n = 3 experiments.

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PMC11367939

Recent studies have suggested the presynaptic localization of ATG9A in neurons [5–8].

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PMC11527437

Treatment with T cells genetically engineered to express tumor-reactive T cell receptors (TCRs), known as TCR-gene therapy (TCR-T), is a promising immunotherapeutic approach for patients with cancer.

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PMC11596967

The net charges of the peptides varied from −3.9 to +2, with Ddes-P4 exhibiting the highest positive charge.

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PMC11672881

An increase in reactive oxygen species (ROS) is typical in mitochondria-related apoptosis .

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PMC10758402

Supernatants were pelleted at 25,000 RPM for 2 hours.

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PMC11422497

Its mechanism of action is also being explored in depth.

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PMC9429973

The adverse event rates for CRS and NE of any grade were 32.70% (p<0.01) and 47.70% (p<0.001) lower, respectively, in patients infused with tisa-cel compared to those infused with axi-cel.

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PMC11549612

Group comparisons were carried out using independent sample t-tests, while Pearson correlation analysis was used to explore relationships between groups.

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PMC11638288

The other putative ligand-binding site resembles the HLA-binding site on killer Ig-related receptors.

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PMC7987994

This could also lead to discrepancies.

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PMC5925824

Each data point is the average of two replicates.

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PMC11562028

Subsequently, 110 μL of the reagent was added to each well and the plates were incubated in a 37 °C incubator for 45 min.

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PMC10729469

Initially to evaluate this, we assessed the distribution of total Tregs (CD4+ CD25+ FoxP3+) by flow cytometry (Fig. 4A) in the spleen, lymph nodes, blood, and brain of WT mice, untreated APP/PS1 mice, or APP/PS1 mice recipients treated with TCRAβ-, polyclonal-, or EV-Treg.

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PMC11539788

Further experiments indicated that RNF19A promoted cell proliferation and inhibited apoptosis in NCSCL by inducing the ubiquitination-mediated degradation of p53.

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PMC11746948

The beads and loading controls were mixed with SDS loading buffer and incubated at 95 °C for 10 min.

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PMC11627133

We demonstrate the effectiveness of our approach in super‐resolution microscopy in secondary mammalian cell lines and primary neurons by RhoBAST‐PAINT, an SMLM protein imaging technique that leverages the transient binding of the fluorogenic rhodamine dye SpyRho to RhoBAST.In single‐molecule localization microscopy (SM...

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PMC9429973

In the multivariable analysis that included age (>60 vs. <60), stage (localized vs. advanced), IPS (<2 vs. >2), extranodal areas, bulky disease and PET3 result, only age and PET3 result had significant impact in PFS (p=0.046 and p=0,001 respectively).

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PMC11802855

CXCL7 can be secreted by MSCs, thereby stimulating MM cells to produce a significant amount of MMP13, which constitutes a crucial means for activating the osteoclast signaling pathway .

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PMC9388315

It is one of the first published reports about the inhibitory properties of Cinnamaldehyde in cancer cells in HL-60 cells.

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PMC11748363

The reason for the absence of antibacterial activity in the current series is unknown.

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PMC11269933

After 36 h, the cells were lysed using a lysis buffer supplemented with protease and phosphatase inhibitors (Beyotime Biotechnology, China).

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PMC11774112

Targeting these mutant genes through gene therapy is an effective method for treating MM.

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PMC9046263

Integrated analyses from The Cancer Genome Atlas demonstrate that HML-6 envelope transcript, ERVK3-1, is a negative prognosticator in glioblastoma patients. (

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PMC11343332

Apoptosis, also known as programmed cell death, is distinguished by DNA fragmentation, cell shrinkage, chromatin condensation, and the activation of certain enzymes known as caspases .

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PMC11594588

In addition, the decrease in NAD+ concentration may also result from excessive substrate consumption, e.g., during inadequate metabolic processes .

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PMC8984067

In vitro experiments showed that the platform has good biosafety, targeting, and PDT tumor treatment effects under the action of NIR light (980 nm).

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PMC11721277

However, it was not possible to achieve satisfactory yields of the target carboxylic acid in any case due to the occurrence of adverse reactions involving chlorin oxidation.

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PMC7342409

The experimental data were expressed as means ± standard deviations ().

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PMC10955424

Multiplex ELISA kit (Thermo Fisher Scientific, Paisley, UK) designed to detect presence of enriched cytokines (IL-1α, IL-1β, IL-5, IL-6, IL-8, IL-10, IL-13, IL-22, G-CSF, INF-γ, TNFα, RANTES (CCL5), leptin and MCP-1 (CCL2) was used in 3 ascites groups, according to their ability to induce chemoresistance in A2780cisR c...

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PMC9429973

Lymphoma cell lines were injected subcutaneously, mAbs were administered i.p.

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PMC9847912

As with other culture-based methods, the IC50 values obtained in our experiments are dependent on the specific assay conditions and cell types used to measure inhibitor susceptibility, and may not precisely reflect the inhibitory potential of GSK232 in various physiological compartments in vivo.

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PMC9429973

Due to both a shortage of carmustine in the past decade and to reduce its pulmonary toxicity, this agent has been replaced in several centers by thiotepa (TEAM).

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PMC9024365

Here we present evidence that SD4 and GluA1 or GluA2 AMPARs bi-directionally increase the cluster size of each other in heterologous cells.

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PMC11765988

It may be assumed that SLRs have a known association, and limited clinical sequelae and sarcoidosis, affecting pathologically and functionally several organs, present the more generalized form of this heterogeneous spectrum, while the exact antigen causing the granuloma formation remains largely unknown .

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