OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11300085	Clinical studies show that omentum, a large fat pad, is the main site for subclinical metastasis of OC and nearly 80% of patients with ovarian carcinoma appear to have omental metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	While non-toxic to VERO cells (IC50 > 400 µg/mL), azurin from P. aeruginosa 2453 significantly inhibited the growth of both T-47D and ZR-75-1 breast cancer cell lines (IC50 = 72.0 ± 3.0 µg/mL).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC11509224	Coincidentally, compound 60 possesses strong activity against Plasmodium falciparum K1, with an IC50 value of 0.98 µM. The total number of diterpenes reported from the Cymbastela sponges is five.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	All structures were drawn in Marvin JS version 21.14.0 (ChemAxon Int.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "structures", "were", "drawn", "in", "Marvin", "JS", "version", ...
PMC11730000	After incubating the primary antibody, the membrane was washed three times with TBS-T for 10 min each time, incubated for 1 h at room temperature with the anti-mouse immunoglobulin G secondary antibody (1:2000 dilution, Cell Signaling), and finally rinsed with TBS-T. mTOR protein expression was detected using a chemilu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	As anticipated, because Torin 2 also inhibits mTOR in complex 1, the phosphorylation of the mTORC1 target, S6 (on S235/236), was significantly reduced in cells treated with Torin 2 (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	In this context, the fluoroquinolone antibiotic Enoxacin has been demonstrated as a potent modulator of miRNA processing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "context", ",", "the", ...
PMC10213199	Owing to significant differences in the low conc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Owing", "to", "significant", "differences", "in", "the", "low", "conc", "." ] } ]
PMC11684297	02.07.2024).	[ { "tags": [ "O", "O", "O" ], "tokens": [ "02.07.2024", ")", "." ] } ]
PMC11469524	Model development statistics (TOP) goodness of fit as reduced chi-square and (BOTTOM) unseen data consistency check as percentage of error reduction compared to unperturbed control as null model for each modeling step from the literature-derived starting model (black and grey arrows in Fig 1D) to the final model (grey–...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8806312	The independent prognostic factors were identified by multivariate Cox proportional hazards regression (MCR) analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "independent", "prognostic", "factors", "were", ...
PMC11670407	k Comparison of differences in GPX4 expression in paraneoplastic and tumor tissues from sarcoma patients in the TCGA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "k", "Comparison", "of", "differen...
PMC9545714	Tomatoes are the major dietary source of the potent antioxidant lycopene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tomatoes", "are", "the", "major", "dietary", "source", "of", "the", "potent", "antiox...
PMC11750696	The UPR is a corrective mechanism aimed at mitigating the stress by reducing overall protein synthesis, boosting the ER’s folding capabilities, and degrading improperly folded proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723210	It is based on the principle of in-line holography, where the incident coherent beam passes through the sample, the scattered beam interferes with the unscattered beam, and the hologram formed by the coherent superposition of the two beams is recorded by the sensor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Probiotics have emerged as a promising adjunctive treatment in HS due to their ability to restore microbial homeostasis, particularly by increasing beneficial skin bacteria such as Cutibacterium spp.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11397654	The complex with calixarenes should allow for the reduction of their cytotoxicity against healthy cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complex", "with", "calixarenes", "should", "allow", ...
PMC11286266	After 24 hr, media was replaced with fresh media containing 50 μM biotin dissolved in DMSO and cells were harvested and lysed the following day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10772747	Through our analysis, we successfully constructed a pharmacological network consisting of 55 nodes and 65 edges connecting “compound-active component-target gene” (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	The presence of the nanosystem was more pronounced in the regions affected by the surgery, a known effect observed in previous studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC3675084	We also investigated the time course of BPR0L075 induced cell cycle arrest when treated with 10 nM BPR0L075.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "investigated", "the", "t...
PMC6114978	A 1.5-fold or greater accumulation of protein was considered indicative of proteosomal degradation. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "1.5-fold", "or", "greater", "accumulation", "of", "protein", ...
PMC10507284	In addition, another study revealed that TROAP could mediate the cell cycle and facilitate the growth of glioma cells by regulating the Wnt/β–catenin pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	The pentose phosphate pathway (PPP) provides these essential commodities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pentose", "phosphate", "pathway", "(", "PPP", ")", "provides", "these", "essen...
PMC10253973	Compound 65 (Figure 25) was effective in reducing cell survival against Staphylococcus aureus and Escherichia coli.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "65", "(", "Figure", "25", ...
PMC11257988	Nichols et al. found through the treatment with another SHP2 inhibitor, RMC-4550 (a small molecule allosteric inhibitor), that it reduces oncogenic RAS-RAF-MEK-ERK signaling and cancer growth by disrupting SOS1-mediated RAS-GTP loading, highlighting SHP2 inhibition as a promising molecular therapeutic strategy for nucl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	1 required dose modification due to unrelated TEAE; none required dose modification for increased HGB or thrombocytosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "required", "dose", "modification", ...
PMC11696576	a Network tree showing linkages between related compounds (Pearson correlation coefficient >0.5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Network", "tree", "showing", "linkages", "between", "r...
PMC11680578	These findings suggest that the synergistic effect of PTX and RGZ can effectively hinder cell proliferation at much lower concentrations than those required for individual treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4485786	P ≤ 0.01, *** P ≤ 0.001. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.01", ",", "", "", "*", "P", "≤", "0.001", ".", "(" ] ...
PMC11377827	Control vs. USP43 sgRNA 1% O2 ***P = 0.0005, two-way ANOVA. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "vs.", "USP43", "sgRNA", "1", "%"...
PMC11706491	Samples were separated by SDS-PAGE and detected by immunoblotting with polyclonal anti-Atf1 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "were", "separated", "by", "SDS-PAGE", "and", "detected", "by", "immun...
PMC9910796	For immuno-EM quantification with anti-ASFV antibodies, the mean labeling density (gold particles/virus) was obtained from 5–10 different budding areas (collectively containing from 60 to 130 closed virus profiles) for each antibody and condition (vEP84Ri +/- IPTG).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11578343	mz‐visco‐NPS measures the viscoelastic response, i.e., elastic G′ and viscous G″, of each cell over a range of frequencies, while still achieving a moderate‐throughput rate of up to 600 cells per hour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10968586	With this premise, it sounds perfectly understandable that scientific evidence has corroborated the role of a healthy diet and dietary intervention as potentially beneficial approaches contributing to cancer prevention .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9119314	This study demonstrates that C. sanguinolenta may be utilized as a sustainable source of novel compounds that may lead to the development of novel agents for the treatment of malaria, African trypanosomiasis, and cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	Since long LOCKs in tumor and normal cell lines are predominantly located within common PMDs (Fig. 3A), with the proportions of the three groups of LOCKs in common PMDs being relatively comparable (Fig. 3B), we assessed the expression levels of the genes (Fig. 3F; Fig. S4A) and OGs (Fig. 3G; Fig. S4B) within these LOCK...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547917	This study contributes to the literature with new data on A. clematitis ethanolic extracts and their analysis on some new antioxidant assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "stud...
PMC11599565	Values represent the expression of such proteins relative to GAPDH after densitometric analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "represent", "the", "expression", "of", "such", "proteins", "relat...
PMC8956657	Significant reductions in nuclear import were observed for the R33A, R24A/R33A, RKR24/AAA24 (RKRA), and delta38 ORF4b constructs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", ...
PMC11474209	While many algae offer benefits, microalgae sometimes trigger the formation of algal blooms (ABs), particularly in aquatic environments, both saltwater favorable and freshwater, when they become densely packed or experience rapid growth due to promising conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Visceral fat mass relative to body weight calculated from axial MRI planes (n = 8 mice per genotype).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visceral", "fat", "mass", ...
PMC10823017	Our study shows that inhibiting PKC-ι can be a viable way to indirectly target c-Myc to interrupt the overactivated pathways that lead to high c-Myc expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Additional objectives include preliminary antitumor activity, and PK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "objectives", "include", "preliminary", "antitumor", "activity", ",", "and", "PK", "." ] ...
PMC11001582	Human C9orf72 ALS/FTD samples for polyGR MSD immunoassay were described previously and protein extracted as described in the biochemical analysis section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "C9orf72", ...
PMC11307990	The data was analyzed using the built-in multimodal size distribution software of the instrument and expressed as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "wa...
PMC11705862	Error bars indicate standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "indicate", "standard", "deviation", "(", "SD", ")", "." ] } ]
PMC10698968	MFS typically arises as a painless and slow-growing mass with infiltrative margins affecting the extremities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MFS", "typically", "arises", "as", "a", "painless", "and", ...
PMC10329237	The present results demonstrated that BLM significantly increased cellular migration, and combined LOS+PFD significantly inhibited the migration of the alveolar basal epithelial cells in comparison with single therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9080589	Then, we examined the effect of PCDH8 on the expression of EMT-related markers in PTC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "we", "examined", "the", "effec...
PMC11190538	Pauwels et al. used equation (6) to compute the percentage of antiviral activity of the tested compound:(6)Antiviralactivity(%)=(meanopticaldensityofcontrolcells−meanopticaldensityoftreatedcells)meanopticaldensityofcontrolcells*100based on these findings, the 50 % CPE inhibitory dosage (ID50) was estimated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8701144	Total HEK293 cell lysates were prepared by lysing cells in ice-cold lysis buffer (50 mM Tris pH 7.5, 150 mM NaCl, 1.5 mM MgCl2, 0.5% Nonidet P-40), and complete protease inhibitor cocktail (Merck) for 20 min on ice.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	The dynamic behavior and stability of best-docked complex between TRMPRSS2 and proposed molecules were assessed through molecular dynamics (MD) simulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dynam...
PMC9429973	ePVS associations with baseline clinical parameters and its prognostic associations with overall survival (OS), time to thrombosis (TTT) and time to bleeding (TTB) were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672142	As such, iron chelator drugs are repurposed or specifically designed as anticancer agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "such", ",", "iron", "chelator", "drugs", "are", "repurpose...
PMC11591030	However, no significant differences were observed between the AOP + LPS and LPS + ML385 + AOP treatment groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "...
PMC11765988	Immunopathogenic pathways in both sarcoidosis and cancer involve immune dysregulation and chronic inflammation as the primary triggers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunopathogenic", "pathways", "in", "both", "sar...
PMC11767793	Ideally, a pair of such control materials would show the full dynamic range for the cell viability assay, from complete cell growth inhibition to full viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983	A431 cells (10 cells/well) were seeded in 6-well plates and incubated for 24 h. The cells were then treated with complex 2’ (37 kBq) in a culture medium for 1 h at 37 °C.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	Next, the effect of neratinib in combination with other targeted agents on growth of HBCCLs were investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "the", "effect", "of", ...
PMC11767793	The absorbance in the range 250 nm to 350 nm shown by the test suspension Au-PEI@NIST slightly decreased after the first centrifugal filtration, then it stabilized after the second through fifth cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Disease risk index was high or very high in 11 patients (24%), and intermediate in 34 patients (76%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7887261	The relative expression levels were calculated with the 2–ΔΔCt method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "expression", "levels", "were", "calculated", "with", "the", "2–ΔΔCt", "method...
PMC9351137	In addition, we observed a specific staining pattern at the mitotic apparatus (centrosomes, spindle, and midbody) during mitotic progression, with the exception of MRG15 that failed to show accumulation to the mitotic structures (Fig. 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	Beyond GC B cells, HGAL (at the transcript level) is also expressed in naive and switched B cells, naive and memory CD4 T cells, and effector CD8 T cells (https://proteinatlas.org; https://fantom.gsc.riken.jp/5/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	Interestingly, by comparing the cytotoxicity results in 3D and the octanol‐water partition coefficient (logP), predicted for [Se(NHC)] ligands by means of the Molinspiration calculator (www.molinspiration.com), no strong linear and/or direct correlations were found, thus suggesting that the hydro/lipophilic balance of ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	During these events, genetic alterations can cause malignant tumor transformation leading to GC-derived B cell lymphoma (33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "these", "events", ...
PMC9429973	Treatment-related adverse events of grade ≥ 3 included neutropenia in 9 pts (53%) and infection in 2 pts (12%); no treatment-related anemia or deaths were reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twenty-eight were fully vaccinated, 8 had incomplete vaccination and only one was unvaccinated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-eight", "were", "fully", "vaccinated", ",", "8", "had", "...
PMC11705547	Another preclinical study demonstrated that inhibition of SCD1 upregulated acetyl coenzyme A acetyltransferase 1 (ACAT1), resulting in increased infiltration and activation of CD8+ T cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	The Cis/Mn/NH@PGP shows a lower ROS level compared to Cis/Mn/@Lipo-IL11 and Cis/Mn/@Lipo-IL11+NH, which can be attributed to the consumption of ROS by the TK bonds within the PGP hydrogel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	The confocal microscope images, on the other hand, offer a more detailed examination of the cells, displaying actin filaments labeled in green, nuclei stained with DAPI in blue, and viable mitochondria stained in red.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10940855	D, Left, representative analysis of phospho-STAT5 in RPMI-8226 cells treated with sh-EFNB2 or sh-Control in presence of EPHB4-Fc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", ",", "Left", ...
PMC11803918	Four hours later, the uptake level of Ce6 was detected using the NovoCyte Quanteon (Agilent).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "hours", "later", ",", "the", ...
PMC11750696	The signaling pathway mediated by IRE1α-XBP1 is associated with increased release of cytokines IL-4, IL-13, and IL-5 in Th2 cells, suggesting a role for this pathway in modulating the Th2 cell secretory profile (45, 46).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11023271	Flow cytometry analyses were performed on LSRII instrument, using FACSDiva software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analyses", "were", "performed", "on", "LSRII", "instrument", ...
PMC11721587	WB analysis of the phosphorylation of RNAi-insensitive (Ins) WT or kinase dead (K33R) Fu stably expressed in Cl8 cells treated with Fu dsRNA and Hh-conditioned or control medium. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11194678	To further verify the effect of STAU1 LLPS on autophagy dysfunction, we sought to test whether similar mechanisms were involved in other neurodegenerative disorders, such as ALS and PD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804	Consequently, at each step the new essentiality value may change dramatically because of the changes in the neighboring PPIs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "at", ...
PMC11575040	The LINC00094 sponge adsorbed miR-19a-3p, which exhibited higher expression in the plasma of patients with breast cancer or ER-positive breast cancer compared with healthy individuals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11585254	There is emerging evidence that certain GPCRs undergo internalization in a β-arrestin-independent manner, although they are still able to recruit β-arrestins following agonist activation (Moo et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	However, many gaps remain in our knowledge of BMS-induced fat reduction and health benefits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "many", "gaps", "remain", "in", "our", ...
PMC11806818	The amplified signal of the TMB/H2O2 system catalyzed by dual nanozymes was detected using DPV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amplified", "signal", "of", "the", "TMB/H2O2", "syst...
PMC8382973	Inflammatory cytokines in the rectum and vagina after 14 consecutive days of rectovaginal application of fusion inhibitor microbicides in male and female NZW rabbits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	There were no differences in frequency of risk factors besides higher frequency of diabetes mellitus in group 3 compared to group 1 (p=0,021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	R. Nedumannil, D. Ritchie, A. Bajel, A. P. Ng, S. J. Harrison, D. Westerman Department of Pathology, Peter MacCallum Cancer Centre, Melbourne; Department of Diagnostic Haematology, Royal Melbourne Hospital, Parkville; Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Me...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The rarity of BPDCN in the pediatric population makes collecting robust safety and efficacy data challenging and there is a paucity of data published for pediatric patients (pts).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635087	The cells were then cultured for more 4 days with daily washing and medium replacement without passaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "cultured", ...
PMC8633974	Thus, gene therapies designed to broadly target then eliminate HIV-1 must overcome strain diversity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "gene", "therapies", "designed", "to", "broadly...
PMC11768281	Fernandez-Ruiz et al. further confirmed the unique patrolling qualities of liver-resident TRM cells, which distinguish them from TEM cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fernandez-Ruiz", "et", "al."...
PMC11496728	The sequence of KO-3 was missing base C, and a base mutation occurred, from A to T, resulting in a change in the codon behind the base.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791432	The analysis of variance results in Supplementary Table 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "of", "variance", "results", "in", "Supplementary", "Table", "3", "." ] } ]
PMC11748335	Regarding potential functional implications, we examined genes covered by long LOCKs over half of their size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "potential", "functional", "implications", ...
PMC6487404	For further investigation, the effect of three different P-gp inhibitors (verapamil, valspodar and ketoconazole) on the REG transport across the everted gut sacs was examined; separately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	Data are shown as mean ± SEM. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "SEM", ".", "", "", "*" ] } ]
PMC10898159	Long non-coding RNAs (lncRNAs) are another important ncRNAs with more than 200nt transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long", "non-coding", "RNAs", "(", "lncRNAs", ")", "are", ...
PMC11200978	The results demonstrate that repeat freezing to −25 °C effectively destroys NSCLC A549 cells, whereas the combination of gemcitabine pre-treatment enhances A549 cell susceptibility to freezing, thereby yielding complete cell death following either a single freeze to −20 °C or a repeat freeze to −15 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O"...
PMC8740518	GC-TOF-MS raw data were processed by Chroma TOF 4.3X software (LECO Corporation, St. Joseph, MI, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GC-TOF-MS", ...
PMC11590870	When the concentration of free radicals exceeds the capacity of cellular antioxidant systems, homeostasis is affected, and biological molecules are damaged, promoting the appearance of chronic conditions such as inflammatory processes, cardiovascular diseases, neural degeneration, diabetes, and cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	To date, there have been no direct measurements of total methane and CO2 emissions from LNG shipping.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "there", "have", ...

PMC11300085

Clinical studies show that omentum, a large fat pad, is the main site for subclinical metastasis of OC and nearly 80% of patients with ovarian carcinoma appear to have omental metastasis .

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PMC11782508

While non-toxic to VERO cells (IC50 > 400 µg/mL), azurin from P. aeruginosa 2453 significantly inhibited the growth of both T-47D and ZR-75-1 breast cancer cell lines (IC50 = 72.0 ± 3.0 µg/mL).

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PMC11509224

Coincidentally, compound 60 possesses strong activity against Plasmodium falciparum K1, with an IC50 value of 0.98 µM. The total number of diterpenes reported from the Cymbastela sponges is five.

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PMC9847912

All structures were drawn in Marvin JS version 21.14.0 (ChemAxon Int.,

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PMC11730000

After incubating the primary antibody, the membrane was washed three times with TBS-T for 10 min each time, incubated for 1 h at room temperature with the anti-mouse immunoglobulin G secondary antibody (1:2000 dilution, Cell Signaling), and finally rinsed with TBS-T. mTOR protein expression was detected using a chemilu...

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PMC10253553

As anticipated, because Torin 2 also inhibits mTOR in complex 1, the phosphorylation of the mTORC1 target, S6 (on S235/236), was significantly reduced in cells treated with Torin 2 (Figure 3).

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PMC11755467

In this context, the fluoroquinolone antibiotic Enoxacin has been demonstrated as a potent modulator of miRNA processing.

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PMC10213199

Owing to significant differences in the low conc.

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PMC11684297

02.07.2024).

[ { "tags": [ "O", "O", "O" ], "tokens": [ "02.07.2024", ")", "." ] } ]

PMC11469524

Model development statistics (TOP) goodness of fit as reduced chi-square and (BOTTOM) unseen data consistency check as percentage of error reduction compared to unperturbed control as null model for each modeling step from the literature-derived starting model (black and grey arrows in Fig 1D) to the final model (grey–...

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PMC8806312

The independent prognostic factors were identified by multivariate Cox proportional hazards regression (MCR) analysis.

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PMC11670407

k Comparison of differences in GPX4 expression in paraneoplastic and tumor tissues from sarcoma patients in the TCGA database.

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PMC9545714

Tomatoes are the major dietary source of the potent antioxidant lycopene.

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PMC11750696

The UPR is a corrective mechanism aimed at mitigating the stress by reducing overall protein synthesis, boosting the ER’s folding capabilities, and degrading improperly folded proteins.

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PMC11723210

It is based on the principle of in-line holography, where the incident coherent beam passes through the sample, the scattered beam interferes with the unscattered beam, and the hologram formed by the coherent superposition of the two beams is recorded by the sensor.

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PMC11767725

Probiotics have emerged as a promising adjunctive treatment in HS due to their ability to restore microbial homeostasis, particularly by increasing beneficial skin bacteria such as Cutibacterium spp.,

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PMC11397654

The complex with calixarenes should allow for the reduction of their cytotoxicity against healthy cells.

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PMC11286266

After 24 hr, media was replaced with fresh media containing 50 μM biotin dissolved in DMSO and cells were harvested and lysed the following day.

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PMC10772747

Through our analysis, we successfully constructed a pharmacological network consisting of 55 nodes and 65 edges connecting “compound-active component-target gene” (Figure 2).

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PMC11604830

The presence of the nanosystem was more pronounced in the regions affected by the surgery, a known effect observed in previous studies.

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PMC3675084

We also investigated the time course of BPR0L075 induced cell cycle arrest when treated with 10 nM BPR0L075.

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PMC6114978

A 1.5-fold or greater accumulation of protein was considered indicative of proteosomal degradation. (

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PMC10507284

In addition, another study revealed that TROAP could mediate the cell cycle and facilitate the growth of glioma cells by regulating the Wnt/β–catenin pathway.

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PMC11394730

The pentose phosphate pathway (PPP) provides these essential commodities.

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PMC10253973

Compound 65 (Figure 25) was effective in reducing cell survival against Staphylococcus aureus and Escherichia coli.

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PMC11257988

Nichols et al. found through the treatment with another SHP2 inhibitor, RMC-4550 (a small molecule allosteric inhibitor), that it reduces oncogenic RAS-RAF-MEK-ERK signaling and cancer growth by disrupting SOS1-mediated RAS-GTP loading, highlighting SHP2 inhibition as a promising molecular therapeutic strategy for nucl...

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PMC9429973

1 required dose modification due to unrelated TEAE; none required dose modification for increased HGB or thrombocytosis.

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PMC11696576

a Network tree showing linkages between related compounds (Pearson correlation coefficient >0.5).

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PMC11680578

These findings suggest that the synergistic effect of PTX and RGZ can effectively hinder cell proliferation at much lower concentrations than those required for individual treatments.

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PMC4485786

P ≤ 0.01, *** P ≤ 0.001. (

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PMC11377827

Control vs. USP43 sgRNA 1% O2 ***P = 0.0005, two-way ANOVA. (

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PMC11706491

Samples were separated by SDS-PAGE and detected by immunoblotting with polyclonal anti-Atf1 .

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PMC9910796

For immuno-EM quantification with anti-ASFV antibodies, the mean labeling density (gold particles/virus) was obtained from 5–10 different budding areas (collectively containing from 60 to 130 closed virus profiles) for each antibody and condition (vEP84Ri +/- IPTG).

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PMC11578343

mz‐visco‐NPS measures the viscoelastic response, i.e., elastic G′ and viscous G″, of each cell over a range of frequencies, while still achieving a moderate‐throughput rate of up to 600 cells per hour.

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PMC10968586

With this premise, it sounds perfectly understandable that scientific evidence has corroborated the role of a healthy diet and dietary intervention as potentially beneficial approaches contributing to cancer prevention .

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PMC9119314

This study demonstrates that C. sanguinolenta may be utilized as a sustainable source of novel compounds that may lead to the development of novel agents for the treatment of malaria, African trypanosomiasis, and cancer.

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PMC11748335

Since long LOCKs in tumor and normal cell lines are predominantly located within common PMDs (Fig. 3A), with the proportions of the three groups of LOCKs in common PMDs being relatively comparable (Fig. 3B), we assessed the expression levels of the genes (Fig. 3F; Fig. S4A) and OGs (Fig. 3G; Fig. S4B) within these LOCK...

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PMC11547917

This study contributes to the literature with new data on A. clematitis ethanolic extracts and their analysis on some new antioxidant assays.

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PMC11599565

Values represent the expression of such proteins relative to GAPDH after densitometric analysis.

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PMC8956657

Significant reductions in nuclear import were observed for the R33A, R24A/R33A, RKR24/AAA24 (RKRA), and delta38 ORF4b constructs.

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PMC11474209

While many algae offer benefits, microalgae sometimes trigger the formation of algal blooms (ABs), particularly in aquatic environments, both saltwater favorable and freshwater, when they become densely packed or experience rapid growth due to promising conditions.

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PMC11335267

Visceral fat mass relative to body weight calculated from axial MRI planes (n = 8 mice per genotype).

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PMC10823017

Our study shows that inhibiting PKC-ι can be a viable way to indirectly target c-Myc to interrupt the overactivated pathways that lead to high c-Myc expression.

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PMC9429973

Additional objectives include preliminary antitumor activity, and PK.

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PMC11001582

Human C9orf72 ALS/FTD samples for polyGR MSD immunoassay were described previously and protein extracted as described in the biochemical analysis section.

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PMC11307990

The data was analyzed using the built-in multimodal size distribution software of the instrument and expressed as the mean ± SD.

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PMC11705862

Error bars indicate standard deviation (SD).

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PMC10698968

MFS typically arises as a painless and slow-growing mass with infiltrative margins affecting the extremities .

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PMC10329237

The present results demonstrated that BLM significantly increased cellular migration, and combined LOS+PFD significantly inhibited the migration of the alveolar basal epithelial cells in comparison with single therapy.

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PMC9080589

Then, we examined the effect of PCDH8 on the expression of EMT-related markers in PTC cells.

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PMC11190538

Pauwels et al. used equation (6) to compute the percentage of antiviral activity of the tested compound:(6)Antiviralactivity(%)=(meanopticaldensityofcontrolcells−meanopticaldensityoftreatedcells)meanopticaldensityofcontrolcells*100based on these findings, the 50 % CPE inhibitory dosage (ID50) was estimated.

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PMC8701144

Total HEK293 cell lysates were prepared by lysing cells in ice-cold lysis buffer (50 mM Tris pH 7.5, 150 mM NaCl, 1.5 mM MgCl2, 0.5% Nonidet P-40), and complete protease inhibitor cocktail (Merck) for 20 min on ice.

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PMC8009078

The dynamic behavior and stability of best-docked complex between TRMPRSS2 and proposed molecules were assessed through molecular dynamics (MD) simulation.

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PMC9429973

ePVS associations with baseline clinical parameters and its prognostic associations with overall survival (OS), time to thrombosis (TTT) and time to bleeding (TTB) were analyzed.

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PMC11672142

As such, iron chelator drugs are repurposed or specifically designed as anticancer agents.

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PMC11591030

However, no significant differences were observed between the AOP + LPS and LPS + ML385 + AOP treatment groups.

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PMC11765988

Immunopathogenic pathways in both sarcoidosis and cancer involve immune dysregulation and chronic inflammation as the primary triggers .

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PMC11767793

Ideally, a pair of such control materials would show the full dynamic range for the cell viability assay, from complete cell growth inhibition to full viability.

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PMC11434983

A431 cells (10 cells/well) were seeded in 6-well plates and incubated for 24 h. The cells were then treated with complex 2’ (37 kBq) in a culture medium for 1 h at 37 °C.

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PMC11092418

Next, the effect of neratinib in combination with other targeted agents on growth of HBCCLs were investigated.

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PMC11767793

The absorbance in the range 250 nm to 350 nm shown by the test suspension Au-PEI@NIST slightly decreased after the first centrifugal filtration, then it stabilized after the second through fifth cycles.

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PMC9429973

Disease risk index was high or very high in 11 patients (24%), and intermediate in 34 patients (76%).

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PMC7887261

The relative expression levels were calculated with the 2–ΔΔCt method.

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PMC9351137

In addition, we observed a specific staining pattern at the mitotic apparatus (centrosomes, spindle, and midbody) during mitotic progression, with the exception of MRG15 that failed to show accumulation to the mitotic structures (Fig. 2).

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PMC11518702

Beyond GC B cells, HGAL (at the transcript level) is also expressed in naive and switched B cells, naive and memory CD4 T cells, and effector CD8 T cells (https://proteinatlas.org; https://fantom.gsc.riken.jp/5/).

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PMC10092581

Interestingly, by comparing the cytotoxicity results in 3D and the octanol‐water partition coefficient (logP), predicted for [Se(NHC)] ligands by means of the Molinspiration calculator (www.molinspiration.com), no strong linear and/or direct correlations were found, thus suggesting that the hydro/lipophilic balance of ...

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PMC9878562

During these events, genetic alterations can cause malignant tumor transformation leading to GC-derived B cell lymphoma (33).

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PMC9429973

Treatment-related adverse events of grade ≥ 3 included neutropenia in 9 pts (53%) and infection in 2 pts (12%); no treatment-related anemia or deaths were reported.

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PMC9429973

Twenty-eight were fully vaccinated, 8 had incomplete vaccination and only one was unvaccinated.

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PMC11705547

Another preclinical study demonstrated that inhibition of SCD1 upregulated acetyl coenzyme A acetyltransferase 1 (ACAT1), resulting in increased infiltration and activation of CD8+ T cells .

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PMC11783017

The Cis/Mn/NH@PGP shows a lower ROS level compared to Cis/Mn/@Lipo-IL11 and Cis/Mn/@Lipo-IL11+NH, which can be attributed to the consumption of ROS by the TK bonds within the PGP hydrogel.

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PMC11534377

The confocal microscope images, on the other hand, offer a more detailed examination of the cells, displaying actin filaments labeled in green, nuclei stained with DAPI in blue, and viable mitochondria stained in red.

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PMC10940855

D, Left, representative analysis of phospho-STAT5 in RPMI-8226 cells treated with sh-EFNB2 or sh-Control in presence of EPHB4-Fc.

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PMC11803918

Four hours later, the uptake level of Ce6 was detected using the NovoCyte Quanteon (Agilent).

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PMC11750696

The signaling pathway mediated by IRE1α-XBP1 is associated with increased release of cytokines IL-4, IL-13, and IL-5 in Th2 cells, suggesting a role for this pathway in modulating the Th2 cell secretory profile (45, 46).

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PMC11023271

Flow cytometry analyses were performed on LSRII instrument, using FACSDiva software.

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PMC11721587

WB analysis of the phosphorylation of RNAi-insensitive (Ins) WT or kinase dead (K33R) Fu stably expressed in Cl8 cells treated with Fu dsRNA and Hh-conditioned or control medium. (

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PMC11194678

To further verify the effect of STAU1 LLPS on autophagy dysfunction, we sought to test whether similar mechanisms were involved in other neurodegenerative disorders, such as ALS and PD.

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PMC5261804

Consequently, at each step the new essentiality value may change dramatically because of the changes in the neighboring PPIs.

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PMC11575040

The LINC00094 sponge adsorbed miR-19a-3p, which exhibited higher expression in the plasma of patients with breast cancer or ER-positive breast cancer compared with healthy individuals.

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PMC11585254

There is emerging evidence that certain GPCRs undergo internalization in a β-arrestin-independent manner, although they are still able to recruit β-arrestins following agonist activation (Moo et al., 2021).

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PMC9352806

However, many gaps remain in our knowledge of BMS-induced fat reduction and health benefits.

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PMC11806818

The amplified signal of the TMB/H2O2 system catalyzed by dual nanozymes was detected using DPV.

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PMC8382973

Inflammatory cytokines in the rectum and vagina after 14 consecutive days of rectovaginal application of fusion inhibitor microbicides in male and female NZW rabbits.

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PMC9429973

There were no differences in frequency of risk factors besides higher frequency of diabetes mellitus in group 3 compared to group 1 (p=0,021).

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PMC9429973

R. Nedumannil, D. Ritchie, A. Bajel, A. P. Ng, S. J. Harrison, D. Westerman Department of Pathology, Peter MacCallum Cancer Centre, Melbourne; Department of Diagnostic Haematology, Royal Melbourne Hospital, Parkville; Department of Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Me...

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PMC9429973

The rarity of BPDCN in the pediatric population makes collecting robust safety and efficacy data challenging and there is a paucity of data published for pediatric patients (pts).

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PMC11635087

The cells were then cultured for more 4 days with daily washing and medium replacement without passaging.

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PMC8633974

Thus, gene therapies designed to broadly target then eliminate HIV-1 must overcome strain diversity.

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PMC11768281

Fernandez-Ruiz et al. further confirmed the unique patrolling qualities of liver-resident TRM cells, which distinguish them from TEM cells .

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PMC11496728

The sequence of KO-3 was missing base C, and a base mutation occurred, from A to T, resulting in a change in the codon behind the base.

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PMC11791432

The analysis of variance results in Supplementary Table 3.

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PMC11748335

Regarding potential functional implications, we examined genes covered by long LOCKs over half of their size.

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PMC6487404

For further investigation, the effect of three different P-gp inhibitors (verapamil, valspodar and ketoconazole) on the REG transport across the everted gut sacs was examined; separately.

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PMC11772585

Data are shown as mean ± SEM. ***

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PMC10898159

Long non-coding RNAs (lncRNAs) are another important ncRNAs with more than 200nt transcripts.

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PMC11200978

The results demonstrate that repeat freezing to −25 °C effectively destroys NSCLC A549 cells, whereas the combination of gemcitabine pre-treatment enhances A549 cell susceptibility to freezing, thereby yielding complete cell death following either a single freeze to −20 °C or a repeat freeze to −15 °C.

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PMC8740518

GC-TOF-MS raw data were processed by Chroma TOF 4.3X software (LECO Corporation, St. Joseph, MI, United States).

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PMC11590870

When the concentration of free radicals exceeds the capacity of cellular antioxidant systems, homeostasis is affected, and biological molecules are damaged, promoting the appearance of chronic conditions such as inflammatory processes, cardiovascular diseases, neural degeneration, diabetes, and cancer .

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PMC9261184

To date, there have been no direct measurements of total methane and CO2 emissions from LNG shipping.

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