OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11594074	The structure was prepared by first removing solvent molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structure", "was", "prepared", "by", "first", "removing", "solvent", "molecules", "." ] } ]
PMC10213199	The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of 360 patients with primary insomnia in a randomized, double-blind, double-simulated experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Second, DLTR-1 and DLTR-2 are top-rated gRNAs from a quadruplex panel designed to cleave most known HIV-1 strains with minimal off-target human genome recognition .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11085211	Thus, no standard chemotherapy has been approved in GIST so far .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "no", "standard", "chemotherapy", "has", "been", "approved", "in", ...
PMC11727000	Our mechanistic studies suggest that the participation of USP44 in these various pathways may depend on its specific domains that differentially mediate interaction with binding partners and substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711871	Overall, the physiological parameters did not differ in both groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "the", "physiological", "parameters", "did", "not", "differ", "in", "b...
PMC3274243	Human hepatocyte carcinoma (HepG2) cells (ECACC, Porton Down, UK) were maintained in Eagles’ minimal essential medium (EMEM) supplemented with 10% FBS.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	If successful, we hope to use this diagnostic model to streamline the diagnostic pathway for patients presenting with a scan suggestive of lymphoma, improving the efficiency of the patient pathway and improving patient experience.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5874706	The protein kinase CK2 is an ubiquitous and pleiotropic serine/threonine kinase with hundreds of endogenous substrates that are implicated in a wide variety of cellular functions (e.g., growth, proliferation, differentiation, apoptosis) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10568263	The 1 mL trisodium citrate aqueous solution (1 wt%) and 140 mg PVP were added to the MnO2 aqueous solution and sonicated for 1 h. The obtained suspension was kept under continuous stirring at 100 °C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11248911	The acetyl pyrazoline, compound 1 and pyrazoline carbothioamides compounds 5, 6, 7 and 8 showed the most potent effect among all the synthesized series (IC50 = 6.2, 5.8, 6.4, 5.8 and 6.2 μM, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	Zeta potential measurement of P5W30-BW-SLNs.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "measurement", "of", "P5W30-BW-SLNs", "." ] } ]
PMC11618052	It has been found that blocking EGFR signaling is recognized as a potent therapeutic strategy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "found", "that", "blocking", "EGFR", ...
PMC11344246	For example, KRAS mutations are present in > 60% of mucinous ovarian carcinomas but are found in <1% of HGSOC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10958426	Then, 1 ml cold PBS containing 2% FBS was added into the tube to suspend the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "1", "ml", "col...
PMC9688728	The observed enrichment in metabolic pathways with significant roles in cancer cells is anticipated concerning the object and the method of analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obser...
PMC10440586	Since gliomas which highly expressed CD99 are adaptable to hypoxia, we speculated CD99 expression is associated with the response to anti-angiogenic therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since",...
PMC11591794	At the same time, Bax expression, another proapototic gene, was observed at the highest level in the DOX and DOX+GA groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11727907	To cross-link PKM2, a batch of cells was washed with PBS after treatments and incubated for 30 min at room temperature with 500 µM DSS (Disuccinimidyl suberate, 21655, Thermo Fisher Scientific, Waltham, MA, USA) for the detection of the tetramers, dimers, and monomers of PKM2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	If a home has an RES, its energy can be used for home loads, ESS charging, or selling to the community.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11679892	After the mixture was prepared, it was incubated at 25 °C for 10 minutes and then at 37 °C for 120 minutes for cDNA synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11407042	CRITICAL: Passage cells when confluence reaches 80%–90%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRITICAL", ":", "Passage", "cells", "when", "confluence", "reaches", "80%–90", "%", "." ] } ]
PMC11799620	Cd-induced apoptosis in HEK293 is caspase-dependent and is due to mitochondrial dysfunction (Mao et al., 2007).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cd-induced", "apoptosis", "in"...
PMC11656657	Co-culture assay with all conditioned medium of OS/PBMC culture was real-time monitored by Incucyte live cell system imaging for five days to assess the tumor clearance by CAR.GD2 T-cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	Compound identification was performed by comparing mass spectra and retention times with reference standards, published data, and various databases web server.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compoun...
PMC10529414	Interestingly, we found that lncRNA TALAM1 was a target of RUNX2 and that RUNX2 exerted a negative regulatory effect on TALAM1 transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC10213179	Sequences of the M12-23 aptamer used for normalization as well as the SCR and ATOP are shown in Table S3.(2)Flow cytometry was used for selected sequences synthesized with a 5′-Cyan5 moiety (BioSpring, Frankfurt, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	Complex (2): 18 mg (76% yield); yellowish solid; H NMR (400 MHz, C6D6): δ 1.00 (s, 18 H, t-Bu), 1.33 (s, 18H, t-Bu), 2.96 (d, 4H, J = 13.8 Hz, −CH2), 3.45 (d, 4H, J = 13.8 Hz, −CH2), 5.80 (t, 2H, J = 2.4 Hz, Ar), 6.34 (d, 2H, J = 2.2 Hz, Ar), 6.74 (s, 4H, Ar), 7.00 (s, 4H, Ar) and 9.10 (d, 4H, J = 2.4 Hz, Ar); C NMR (1...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684821	TCR sequencing of the cancer-reactive T cell populations in these lines revealed recurrence of TRAJ42 use (Figure 3C), thereby generating unusually long CDR3-α (16 or 17 amino acids) incorporating a 10 amino conserved TCR-α chain motif (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11435360	CD4 T cells comprise several subsets of immune cells, including immunosuppressive regulatory T cells, which are abundant in BC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD4", "T", "cells...
PMC7039683	Three independent measurements were performed for each transfection group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "independent", "measurements", "were", "performed", "for", "each", "transfection", "group", "." ...
PMC11754432	The lipid bilayer can be separated into highly regulated liquid-ordered phases (Lo) comprising of saturated phospholipids with high cholesterol and sphingomyelin concentrations or liquid-disordered (Ld) phases with unsaturated phospholipids and reduced cholesterol composition .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10048572	As a measure of association for tables 2 × 2, the odds ratio (OR) is given with the corresponding 95% confidence interval (Ci).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	Heatmap was conducted using R 4.2.1 (https://www.r-project.org).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "was", "conducted", "using", "R", "4.2.1", "(", "https://www.r-project.org", ")", "." ] } ]
PMC10419319	Tumor volume was measured via caliper measurement and calculated using the following formula: length × width × 1/2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "volume", "was", "measure...
PMC9429973	Patients were examined by psychiatrist using the Brief Psychiatric Rating Scale, as well as some psychometric methods.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "examined", "by", "...
PMC8414691	Then, we used HeLa cells stably expressing EGFP::α-Tubulin and assessed whether SRCAP depletion influences microtubule regrowth after cold-induced disassembly.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "we", ...
PMC8409415	The intensity and density of positive staining were scored by three independent gynecological pathologists (SM, RN, and MS) who were blinded to clinico‐pathological information, as described in the Supporting Information Materials and Methods section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583690	The supernatant was then collected for further analysis, while the DTX-loaded nanoparticles were air-dried.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "then", "collected", "for", "fu...
PMC11752740	These proteins are found on the surfaces of various cells, including normal cells; however, their increased expression in certain cancers contributes to drug resistance by actively expelling anticancer agents from the cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8540611	Experiments were carried out on HeLa, human acute promyelocytic leukemia (HL-60), and T-cell acute lymphoblastic leukemia (CEM-SS).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], ...
PMC10788478	In NSCLC, CTNNB1 exon 3 mutations are associated with an unfavorable prognosis. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "NSCLC", ",", "CTNNB1", "exon", "3", "mutations", "are", ...
PMC10719213	The human leukemic Jurkat E6.1 cell line (pseudodiploid, modal No 46) and the CCRF-CEM (ECACC 85112105) cell line (2n = 46) were obtained from the European Collection of Authenticated Cell Cultures (ECACC) general cell collection and cultured according to the recommended instructions (Jurkat E6.1: RPMI 1640; 2 mM gluta...	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", ...
PMC11634794	These results suggest that reduced LAMP1 expression may be linked to advanced tumor progression in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "reduced", "LAMP...
PMC8864075	Glucose-6-phosphate isomerase edited by GPI catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glucose-6-phosphate", "isomerase", "edited", "by", "GPI", "catalyzes", "the", "convers...
PMC11473843	Future studies are warranted to understand which specific signals trigger ERK5 upregulation during the development of resistance to FAK inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "studies", "are", ...
PMC11726848	Due to the dependence of tetrazole stain-based tests on the metabolic status of cells which can lead to erroneously high levels of evaluated inhibitory effect, we have additionally stained attached cells with vital stain Hoechst 33342 and counted cells using fluorescence microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705862	GAPDH was used as a control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "was", "used", "as", "a", "control", "." ] } ]
PMC11441402	E-H) Zoomed in images of cells, demonstrating nuclear Hoechst-33342 staining of all cells (blue) and SYTOX green staining of dead cells (green).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	We note that fixation-induced changes of LLPS appearance may lead to potential misinterpretation of the functional relevance of LLPS in cellular processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "note",...
PMC11680578	An angiogenesis assay was conducted to assess the effectiveness of combined treatment in the CAM (chick chorioallantois membrane) in-vivo model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "angiog...
PMC11770746	Samples were dissolved in accordance with their solubility in 1:1 MeOH/phosphate buffer (100 mM, pH 7.0) or only MeOH in which pH was adjusted to pH 7.0 using sodium hydroxide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541409	The reversible nature of currently approved TKIs allows for the leaky activation of oncoproteins, contributing to GIST cell survival and resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rever...
PMC11612315	Electrophysiological analyses revealed that exendin 9–39 binds to the extracellular side of TRPV1, functioning as a noncompetitive inhibitor of CAP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrophysiological", ...
PMC10490530	The over-expression of p53 and doxorubicin treatment decreased NF-κB binding to the PIK3CA promoter, and a further decrease was seen with a combination treatment of TNFα and doxorubicin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	Incorporation of straight-chain ethers at the 5-position (21, 25) results in an increase in the mouse IV clearance (58 and 51 mL/min/kg, respectively) from the 4,5-dimethoxy ether (19, 20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	The figure was Created in BioRender.com.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "was", "Created", "in", "BioRender.com", "." ] } ]
PMC10506676	The qRT-PCR ABI QuantStudio3 instrument (Applied Biosystems, Grand Island, NY, USA) was employed for this purpose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "qRT-PCR", ...
PMC10443665	CCRF-CEM cells and CCRF-CEM/R were used as negative and positive controls, respectively.	[ { "tags": [ "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCRF-CEM", "cells", "and", "CCRF-CEM/R", "were", "used", "as", ...
PMC11746942	Notably, we found FTY720 treatment significantly decreased STAT3 activation and its downstream Survivin in vitro or in vivo. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "we", "...
PMC9429973	Image: Summary/Conclusion: These data indicate that activation of PKR with mitapivat improves markers of ineffective erythropoiesis and iron homeostasis in PK deficiency, thereby decreasing FeO in these pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Data were formatted by hand to facilitate further analysis and analysis (e.g. extraction of the main barriers) conducted through iterative Thematic Analysis until data saturation was reached.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694066	We first assessed R-loop levels in DSRCT cells using RNA:DNA hybrid dot blotting with the S9.6 antibody on genomic DNA extracted from JN1 or R cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Their evaluation was based on the assessment of nuclear and cytoplasmic staining percentages as well as intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "evaluation", "was", "based", "on", ...
PMC9429973	Results: Treatment with esomeprazole resulted in a statistically significant reduction in liver iron content that was 0.55mg Fe/g dw larger than after treatment with placebo (95% CI [0.05 to 1.06]; p=0.03).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11283030	NC: parental cells, VC: nonsense RNAi; Si: ACLY silencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NC", ":", "parental", "cells", ",", "VC", ":", "nonsense", ...
PMC11525028	Overall survival (left) and LMFS (right) of patients according to the expression levels of NAT10, by log-rank test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11740508	D PDX TM00089, n = 6 animals per group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "PDX", "TM00089", ",", "n", "=", "6", "animals", "per", "group", "." ] } ]
PMC6312945	Therefore, in this study, MHCC97-L and BEL-7404 cells were, respectively, used to replicate the HBV-associated liver cancer model and non-HBV replication liver cancer model, in order to explore the effect of miR-101 and miR-345 on HBV replication and hepatoma cell growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8922418	The potential targets for HIV-1/AIDS gene therapy can be divided into four categories: (1) HIV-1 co-receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potential", "targets", "fo...
PMC6024716	First strand cDNA was synthesized from total RNA using the Maxima First strand cDNA synthesis kit for real time quantitative PCR (RT-qPCR) (Thermo Scientific, # K1642, Vilnius Lithuania).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	Considering that the paracrine secretions of MSCs from different sources can be highly variable, which in turn results from the difference in the gene expression pattern of these cells , it seems that AD-MSC has more effective content in improving gene expression patterns of IL-1β-induced Caco-2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5415764	Previous studies have confirmed the synergistic anticancer activities of clinical anticancer drugs such as sorafenib9, cisplatin10, 5-fluorouracil11 in combination with TET.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previou...
PMC7519871	When used in combination with cisplatin or other 2nd and 3rd generation platinum drugs, phytochemicals can offer promising benefits in terms of compromising the toxicities or inducing the sensitization towards chemotherapeutics or reducing the drug dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	However, valproic acid (VPA), another HDAC inhibitor with global effects on cellular gene expression blocks EBV lytic gene expression in Burkitt lymphoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLin...
PMC10033453	Plates were sealed with Breathe-Easy membrane (Research Products International, Mt. Prospect, IL, USA) and placed into IncuCyte S3 (Sartorius).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11657695	In 85% of cases, ES is characterised by the formation of the fusion protein EWS::FLI1 , and in 10% of cases, by the chimeric protein EWS::ERG , both acting as an oncogene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	Highly selective PRMT inhibitors, including the PRMT7 inhibitor SGC8158, the PRMT5 inhibitor EPZ015666, and the Type I PRMT inhibitor MS023, were used to parse out the activity of individual classes of PRMTs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Transcription factors play an important role in the regulation of gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transcription", "factors", "play", "an", "important", "role", "in", "the", "regu...
PMC11437637	Table 2PBLs comparison between healthy individuals and EC patientsThe healthyEndometrial carcinomat/ZP valueBody immune function testN=180N=146 Total lymphocyte2031±399.681754.09±581.414.893<0.001 CD3+ lymphocyte1420(1210.75,1637.75)1229(1029.75,1565)-4.366<0.001 CD4+T cell761.5(667.25,895.75)778.5(593.25,964.25)-0.159...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10376064	Cells were cultured as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "as", "previously", "described", "." ] } ]
PMC11277157	Note that STAT1 acts as a hub for several transcription factors that belong to the ATF, EGR, and FOS families.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", "that...
PMC11635087	At 2 days after the co-cultivation, we detected an increase in the space between thylakoid membranes in some chloroplasts, which also had enlarged plastoglobules (i.e., plastoquinone-containing lipoprotein particles present in chloroplasts under biotic stress conditions) (Fig. 5F, G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9111184	This Spectral range provides information about nucleic acids, proteins, and lipids (Ali et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "Spectral", "range", ...
PMC11472639	Harrison D. Collier-Bain: Writing – review & editing, Writing – original draft, Project administration, Methodology, Investigation, Formal analysis, Data curation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8903741	After screening, positive subclones were grown to larger volumes, and antibodies obtained from each cell supernatant were purified according to our previous experimental method regarding antibody purification .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	AELN prognostic classification was more superior in sensitivity and accuracy than ELN-2010 in distinguishing different risk group categories with the AUC value of 0.724 vs. 0.631 respectively in the training cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7759933	Genes encoding hepatic markers, metabolic phase I/II enzymes, were time-dependently deregulated compared to monolayers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genes", "encoding", "hepatic", "markers", ",", "metabo...
PMC11224020	Using a homemade macro, the plane of the nucleus was used to quantify the florescence intensity by making a mask on both the nucleus (DAPI channel) and the cell (phalloidin channel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: A total of 164 patients diagnosed with PG-TCL from 1975 to 2016 extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10713411	Later, the PRPCDGs risk signature, consisting of ATP6V0A4, ATP6V1C2, DCN, MT1G, MYH14, NTRK2, PROM2, TRIB3 and UCHL1, was identified by the LASSO regression analysis according to PRPCDGs’ expression in TCGA-KIRC dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	Data are shown as (mean ± SEM, PKAsub-DDX4-PixDE/TPPP-FHA1, n = 3; PKAsub-DDX4-PixDE/TPPP, n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "sh...
PMC11023271	While statistically significant, the occurrence of mutated RIPK4 is relatively rare in SCC [12–14].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "statistically", "significant", ",", "the...
PMC10873328	The Pearson and Spearman correlation analysis of TGFBI and EPAS1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Pearson", "and", "Spearman", "correlation", "analysis", "of", "TGFBI", "and", ...
PMC11705067	All data shown are representative of at least three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "shown", "are", "representative", "of", "at", "least", "three", "indepe...
PMC9812014	EC50 values of 3.8 μM and 2.0 μM were established for the African and Asian CHIKV genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EC50", "values", "of", "3.8", "μM", "and", ...
PMC10079526	Next, we investigated the sensitivity of homologous recombination deficient cells (RPE-1 p53-/- BRCA1 -/-) (Fig. 3D) for 5-Aza-2’ and SUMO E1 inhibitor TAK981 treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	Treatment of XB002 with cathepsin B resulted in the release of the free payload ZD02044, as confirmed by RP-HPLC and LC/MS analysis (Supplementary Fig. S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Despite significant progress that has been made in the development of a number of new anti-cancer therapies using traditional cancer models, these systems have limited applicability in screening of personalized treatments as these are unable to reliably reproduce the heterogeneity of tumour tissue and the variation in ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Of the DHL patients in the early PD group (n=8), MYC/BCL2 rearrangement was present in 87.5%, MYC/BCL6 in 12.5%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11594074

The structure was prepared by first removing solvent molecules.

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PMC10213199

The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality of 360 patients with primary insomnia in a randomized, double-blind, double-simulated experiment.

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PMC8633974

Second, DLTR-1 and DLTR-2 are top-rated gRNAs from a quadruplex panel designed to cleave most known HIV-1 strains with minimal off-target human genome recognition .

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PMC11085211

Thus, no standard chemotherapy has been approved in GIST so far .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "no", "standard", "chemotherapy", "has", "been", "approved", "in", ...

PMC11727000

Our mechanistic studies suggest that the participation of USP44 in these various pathways may depend on its specific domains that differentially mediate interaction with binding partners and substrates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11711871

Overall, the physiological parameters did not differ in both groups.

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PMC3274243

Human hepatocyte carcinoma (HepG2) cells (ECACC, Porton Down, UK) were maintained in Eagles’ minimal essential medium (EMEM) supplemented with 10% FBS.

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PMC9429973

If successful, we hope to use this diagnostic model to streamline the diagnostic pathway for patients presenting with a scan suggestive of lymphoma, improving the efficiency of the patient pathway and improving patient experience.

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PMC5874706

The protein kinase CK2 is an ubiquitous and pleiotropic serine/threonine kinase with hundreds of endogenous substrates that are implicated in a wide variety of cellular functions (e.g., growth, proliferation, differentiation, apoptosis) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10568263

The 1 mL trisodium citrate aqueous solution (1 wt%) and 140 mg PVP were added to the MnO2 aqueous solution and sonicated for 1 h. The obtained suspension was kept under continuous stirring at 100 °C for 30 min.

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PMC11248911

The acetyl pyrazoline, compound 1 and pyrazoline carbothioamides compounds 5, 6, 7 and 8 showed the most potent effect among all the synthesized series (IC50 = 6.2, 5.8, 6.4, 5.8 and 6.2 μM, respectively).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740907

Zeta potential measurement of P5W30-BW-SLNs.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "measurement", "of", "P5W30-BW-SLNs", "." ] } ]

PMC11618052

It has been found that blocking EGFR signaling is recognized as a potent therapeutic strategy.

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PMC11344246

For example, KRAS mutations are present in > 60% of mucinous ovarian carcinomas but are found in <1% of HGSOC.

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PMC10958426

Then, 1 ml cold PBS containing 2% FBS was added into the tube to suspend the cells.

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PMC9688728

The observed enrichment in metabolic pathways with significant roles in cancer cells is anticipated concerning the object and the method of analysis.

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PMC10440586

Since gliomas which highly expressed CD99 are adaptable to hypoxia, we speculated CD99 expression is associated with the response to anti-angiogenic therapy.

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PMC11591794

At the same time, Bax expression, another proapototic gene, was observed at the highest level in the DOX and DOX+GA groups.

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PMC11727907

To cross-link PKM2, a batch of cells was washed with PBS after treatments and incubated for 30 min at room temperature with 500 µM DSS (Disuccinimidyl suberate, 21655, Thermo Fisher Scientific, Waltham, MA, USA) for the detection of the tetramers, dimers, and monomers of PKM2.

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PMC9622879

If a home has an RES, its energy can be used for home loads, ESS charging, or selling to the community.

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PMC11679892

After the mixture was prepared, it was incubated at 25 °C for 10 minutes and then at 37 °C for 120 minutes for cDNA synthesis.

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PMC11407042

CRITICAL: Passage cells when confluence reaches 80%–90%.

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PMC11799620

Cd-induced apoptosis in HEK293 is caspase-dependent and is due to mitochondrial dysfunction (Mao et al., 2007).

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PMC11656657

Co-culture assay with all conditioned medium of OS/PBMC culture was real-time monitored by Incucyte live cell system imaging for five days to assess the tumor clearance by CAR.GD2 T-cells.

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PMC11687663

Compound identification was performed by comparing mass spectra and retention times with reference standards, published data, and various databases web server.

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PMC10529414

Interestingly, we found that lncRNA TALAM1 was a target of RUNX2 and that RUNX2 exerted a negative regulatory effect on TALAM1 transcription.

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PMC10213179

Sequences of the M12-23 aptamer used for normalization as well as the SCR and ATOP are shown in Table S3.(2)Flow cytometry was used for selected sequences synthesized with a 5′-Cyan5 moiety (BioSpring, Frankfurt, Germany).

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PMC9386809

Complex (2): 18 mg (76% yield); yellowish solid; H NMR (400 MHz, C6D6): δ 1.00 (s, 18 H, t-Bu), 1.33 (s, 18H, t-Bu), 2.96 (d, 4H, J = 13.8 Hz, −CH2), 3.45 (d, 4H, J = 13.8 Hz, −CH2), 5.80 (t, 2H, J = 2.4 Hz, Ar), 6.34 (d, 2H, J = 2.2 Hz, Ar), 6.74 (s, 4H, Ar), 7.00 (s, 4H, Ar) and 9.10 (d, 4H, J = 2.4 Hz, Ar); C NMR (1...

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PMC11684821

TCR sequencing of the cancer-reactive T cell populations in these lines revealed recurrence of TRAJ42 use (Figure 3C), thereby generating unusually long CDR3-α (16 or 17 amino acids) incorporating a 10 amino conserved TCR-α chain motif (Figure 3D).

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PMC11435360

CD4 T cells comprise several subsets of immune cells, including immunosuppressive regulatory T cells, which are abundant in BC .

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PMC7039683

Three independent measurements were performed for each transfection group.

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PMC11754432

The lipid bilayer can be separated into highly regulated liquid-ordered phases (Lo) comprising of saturated phospholipids with high cholesterol and sphingomyelin concentrations or liquid-disordered (Ld) phases with unsaturated phospholipids and reduced cholesterol composition .

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PMC10048572

As a measure of association for tables 2 × 2, the odds ratio (OR) is given with the corresponding 95% confidence interval (Ci).

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PMC10582049

Heatmap was conducted using R 4.2.1 (https://www.r-project.org).

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PMC10419319

Tumor volume was measured via caliper measurement and calculated using the following formula: length × width × 1/2.

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PMC9429973

Patients were examined by psychiatrist using the Brief Psychiatric Rating Scale, as well as some psychometric methods.

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PMC8414691

Then, we used HeLa cells stably expressing EGFP::α-Tubulin and assessed whether SRCAP depletion influences microtubule regrowth after cold-induced disassembly.

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PMC8409415

The intensity and density of positive staining were scored by three independent gynecological pathologists (SM, RN, and MS) who were blinded to clinico‐pathological information, as described in the Supporting Information Materials and Methods section.

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PMC11583690

The supernatant was then collected for further analysis, while the DTX-loaded nanoparticles were air-dried.

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PMC11752740

These proteins are found on the surfaces of various cells, including normal cells; however, their increased expression in certain cancers contributes to drug resistance by actively expelling anticancer agents from the cells .

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PMC8540611

Experiments were carried out on HeLa, human acute promyelocytic leukemia (HL-60), and T-cell acute lymphoblastic leukemia (CEM-SS).

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PMC10788478

In NSCLC, CTNNB1 exon 3 mutations are associated with an unfavorable prognosis. ,

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PMC10719213

The human leukemic Jurkat E6.1 cell line (pseudodiploid, modal No 46) and the CCRF-CEM (ECACC 85112105) cell line (2n = 46) were obtained from the European Collection of Authenticated Cell Cultures (ECACC) general cell collection and cultured according to the recommended instructions (Jurkat E6.1: RPMI 1640; 2 mM gluta...

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PMC11634794

These results suggest that reduced LAMP1 expression may be linked to advanced tumor progression in ccRCC.

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PMC8864075

Glucose-6-phosphate isomerase edited by GPI catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate.

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PMC11473843

Future studies are warranted to understand which specific signals trigger ERK5 upregulation during the development of resistance to FAK inhibitors.

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PMC11726848

Due to the dependence of tetrazole stain-based tests on the metabolic status of cells which can lead to erroneously high levels of evaluated inhibitory effect, we have additionally stained attached cells with vital stain Hoechst 33342 and counted cells using fluorescence microscopy.

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PMC11705862

GAPDH was used as a control.

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PMC11441402

E-H) Zoomed in images of cells, demonstrating nuclear Hoechst-33342 staining of all cells (blue) and SYTOX green staining of dead cells (green).

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PMC9817179

We note that fixation-induced changes of LLPS appearance may lead to potential misinterpretation of the functional relevance of LLPS in cellular processes.

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PMC11680578

An angiogenesis assay was conducted to assess the effectiveness of combined treatment in the CAM (chick chorioallantois membrane) in-vivo model.

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PMC11770746

Samples were dissolved in accordance with their solubility in 1:1 MeOH/phosphate buffer (100 mM, pH 7.0) or only MeOH in which pH was adjusted to pH 7.0 using sodium hydroxide.

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PMC11541409

The reversible nature of currently approved TKIs allows for the leaky activation of oncoproteins, contributing to GIST cell survival and resistance.

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PMC11612315

Electrophysiological analyses revealed that exendin 9–39 binds to the extracellular side of TRPV1, functioning as a noncompetitive inhibitor of CAP.

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PMC10490530

The over-expression of p53 and doxorubicin treatment decreased NF-κB binding to the PIK3CA promoter, and a further decrease was seen with a combination treatment of TNFα and doxorubicin.

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PMC11345828

Incorporation of straight-chain ethers at the 5-position (21, 25) results in an increase in the mouse IV clearance (58 and 51 mL/min/kg, respectively) from the 4,5-dimethoxy ether (19, 20).

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PMC10809689

The figure was Created in BioRender.com.

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PMC10506676

The qRT-PCR ABI QuantStudio3 instrument (Applied Biosystems, Grand Island, NY, USA) was employed for this purpose.

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PMC10443665

CCRF-CEM cells and CCRF-CEM/R were used as negative and positive controls, respectively.

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PMC11746942

Notably, we found FTY720 treatment significantly decreased STAT3 activation and its downstream Survivin in vitro or in vivo. (

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PMC9429973

Image: Summary/Conclusion: These data indicate that activation of PKR with mitapivat improves markers of ineffective erythropoiesis and iron homeostasis in PK deficiency, thereby decreasing FeO in these pts.

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PMC10936243

Data were formatted by hand to facilitate further analysis and analysis (e.g. extraction of the main barriers) conducted through iterative Thematic Analysis until data saturation was reached.

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PMC11694066

We first assessed R-loop levels in DSRCT cells using RNA:DNA hybrid dot blotting with the S9.6 antibody on genomic DNA extracted from JN1 or R cells.

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PMC11406030

Their evaluation was based on the assessment of nuclear and cytoplasmic staining percentages as well as intensity.

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PMC9429973

Results: Treatment with esomeprazole resulted in a statistically significant reduction in liver iron content that was 0.55mg Fe/g dw larger than after treatment with placebo (95% CI [0.05 to 1.06]; p=0.03).

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PMC11283030

NC: parental cells, VC: nonsense RNAi; Si: ACLY silencing.

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PMC11525028

Overall survival (left) and LMFS (right) of patients according to the expression levels of NAT10, by log-rank test. (

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PMC11740508

D PDX TM00089, n = 6 animals per group.

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PMC6312945

Therefore, in this study, MHCC97-L and BEL-7404 cells were, respectively, used to replicate the HBV-associated liver cancer model and non-HBV replication liver cancer model, in order to explore the effect of miR-101 and miR-345 on HBV replication and hepatoma cell growth.

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PMC8922418

The potential targets for HIV-1/AIDS gene therapy can be divided into four categories: (1) HIV-1 co-receptors.

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PMC6024716

First strand cDNA was synthesized from total RNA using the Maxima First strand cDNA synthesis kit for real time quantitative PCR (RT-qPCR) (Thermo Scientific, # K1642, Vilnius Lithuania).

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PMC11519077

Considering that the paracrine secretions of MSCs from different sources can be highly variable, which in turn results from the difference in the gene expression pattern of these cells , it seems that AD-MSC has more effective content in improving gene expression patterns of IL-1β-induced Caco-2 cells.

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PMC5415764

Previous studies have confirmed the synergistic anticancer activities of clinical anticancer drugs such as sorafenib9, cisplatin10, 5-fluorouracil11 in combination with TET.

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PMC7519871

When used in combination with cisplatin or other 2nd and 3rd generation platinum drugs, phytochemicals can offer promising benefits in terms of compromising the toxicities or inducing the sensitization towards chemotherapeutics or reducing the drug dose.

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PMC11025866

However, valproic acid (VPA), another HDAC inhibitor with global effects on cellular gene expression blocks EBV lytic gene expression in Burkitt lymphoma cell lines.

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PMC10033453

Plates were sealed with Breathe-Easy membrane (Research Products International, Mt. Prospect, IL, USA) and placed into IncuCyte S3 (Sartorius).

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PMC11657695

In 85% of cases, ES is characterised by the formation of the fusion protein EWS::FLI1 , and in 10% of cases, by the chimeric protein EWS::ERG , both acting as an oncogene.

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PMC10745221

Highly selective PRMT inhibitors, including the PRMT7 inhibitor SGC8158, the PRMT5 inhibitor EPZ015666, and the Type I PRMT inhibitor MS023, were used to parse out the activity of individual classes of PRMTs.

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PMC8973725

Transcription factors play an important role in the regulation of gene expression.

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PMC11437637

Table 2PBLs comparison between healthy individuals and EC patientsThe healthyEndometrial carcinomat/ZP valueBody immune function testN=180N=146 Total lymphocyte2031±399.681754.09±581.414.893<0.001 CD3+ lymphocyte1420(1210.75,1637.75)1229(1029.75,1565)-4.366<0.001 CD4+T cell761.5(667.25,895.75)778.5(593.25,964.25)-0.159...

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PMC10376064

Cells were cultured as previously described .

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PMC11277157

Note that STAT1 acts as a hub for several transcription factors that belong to the ATF, EGR, and FOS families.

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PMC11635087

At 2 days after the co-cultivation, we detected an increase in the space between thylakoid membranes in some chloroplasts, which also had enlarged plastoglobules (i.e., plastoquinone-containing lipoprotein particles present in chloroplasts under biotic stress conditions) (Fig. 5F, G).

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PMC9111184

This Spectral range provides information about nucleic acids, proteins, and lipids (Ali et al., 2018).

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PMC11472639

Harrison D. Collier-Bain: Writing – review & editing, Writing – original draft, Project administration, Methodology, Investigation, Formal analysis, Data curation.

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PMC8903741

After screening, positive subclones were grown to larger volumes, and antibodies obtained from each cell supernatant were purified according to our previous experimental method regarding antibody purification .

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PMC9429973

AELN prognostic classification was more superior in sensitivity and accuracy than ELN-2010 in distinguishing different risk group categories with the AUC value of 0.724 vs. 0.631 respectively in the training cohort.

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PMC7759933

Genes encoding hepatic markers, metabolic phase I/II enzymes, were time-dependently deregulated compared to monolayers.

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PMC11224020

Using a homemade macro, the plane of the nucleus was used to quantify the florescence intensity by making a mask on both the nucleus (DAPI channel) and the cell (phalloidin channel).

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PMC9429973

Methods: A total of 164 patients diagnosed with PG-TCL from 1975 to 2016 extracted from the Surveillance, Epidemiology, and End Results Program (SEER) database were analyzed.

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PMC10713411

Later, the PRPCDGs risk signature, consisting of ATP6V0A4, ATP6V1C2, DCN, MT1G, MYH14, NTRK2, PROM2, TRIB3 and UCHL1, was identified by the LASSO regression analysis according to PRPCDGs’ expression in TCGA-KIRC dataset.

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PMC11342785

Data are shown as (mean ± SEM, PKAsub-DDX4-PixDE/TPPP-FHA1, n = 3; PKAsub-DDX4-PixDE/TPPP, n = 3).

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PMC11023271

While statistically significant, the occurrence of mutated RIPK4 is relatively rare in SCC [12–14].

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PMC10873328

The Pearson and Spearman correlation analysis of TGFBI and EPAS1. (

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PMC11705067

All data shown are representative of at least three independent experiments.

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PMC9812014

EC50 values of 3.8 μM and 2.0 μM were established for the African and Asian CHIKV genotypes.

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PMC10079526

Next, we investigated the sensitivity of homologous recombination deficient cells (RPE-1 p53-/- BRCA1 -/-) (Fig. 3D) for 5-Aza-2’ and SUMO E1 inhibitor TAK981 treatment.

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PMC11791478

Treatment of XB002 with cathepsin B resulted in the release of the free payload ZD02044, as confirmed by RP-HPLC and LC/MS analysis (Supplementary Fig. S4).

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PMC7823217

Despite significant progress that has been made in the development of a number of new anti-cancer therapies using traditional cancer models, these systems have limited applicability in screening of personalized treatments as these are unable to reliably reproduce the heterogeneity of tumour tissue and the variation in ...

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PMC9429973

Of the DHL patients in the early PD group (n=8), MYC/BCL2 rearrangement was present in 87.5%, MYC/BCL6 in 12.5%.

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