OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC7057940	The Carl Zeiss fluorescence microscope (Axio-Scope A1) with image capture software was used for the evaluation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Carl", "Zeiss", "fluorescence", ...
PMC11659734	The metabolic activation was provided by rat liver homogenate (S9 fraction).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "metabolic", "activation", "was", "provided", "by", "rat", "liver", ...
PMC9429973	Treatment is continued until PD or unacceptable toxicity or for a maximum of 1.5 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "is", "continued", "until", "PD", "or", "unacce...
PMC9429973	Patients with PG-TCL generally exhibited poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "PG-TCL", "generally", "exhibited", "poor", "prognosis", "." ] } ]
PMC9917080	At the same time, in astrocytes of the cerebral cortex, sorafenib, selenium nanoparticles, and the selenium-sorafenib nanocomplex did not cause cell death either after 24 or after 48 h of incubation, which indicates the target orientation of the studied agents on cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792766	Additionally, various other solvents and food simulants have been used in literature for the preparation of samples, including 95% v/v ethanol, isooctane, methanol, n‐heptane, and ethane (Bradley et al., 2008, 2010; Groh & Muncke, 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	When analyzed by BOR, the median percentage change (decrease) from BL in CS dose was similar in RUX and BAT responders but was smaller in BAT vs RUX nonresponders (Figure).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Group 1 (n=195) had known adverse risk cytogenetics (Grimwade et al, Blood 2010,116, 354) and were randomised at diagnosis between 4 courses of CPX-351 and 2 courses of FLAG-Ida followed by MACE/MidAC consolidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10362265	The complex structure illustrates the mobile regions colored red. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complex", "structure", "illustrates", "the", "mobile", "regions", "colored", "red", ".", ...
PMC10713411	Gene expression and coefficients derived from LASSO Cox regression were used for the establishment of the formula for risk score computation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", ...
PMC5034105	The gradual onset of CPE in most of these cell lines at 3 d.p.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gradual", "onset", "of", "CPE", "in", "most", "of", ...
PMC9780037	For simplicity, some of the elements of these delivery systems were omitted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "simplicity", ",", "some", "of", "the", "elements", "of", "thes...
PMC10818573	In an additional assessment, the reaction time was fixed at 15 min for the initial reaction temperatures tested, including 25 °C, 35 °C, and 45 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679326	Despite limited data on their structure and properties, their ability to interact with mammalian immunoglobulins and recognize aberrant glycosylation on human cells suggests significant potential for these molecules to develop new biotechnological and biomedical technologies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10932641	The Wnt-β-catenin system is an evolutionarily conserved signaling pathway that plays a crucial role in regulating embryonic development, cell differentiation, proliferation, and adult stem cell homeostasis (34,35).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753949	384–473, partially overlapped with a 45 a.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "384–473", ",", "partially", "overlapped", "with", "a", "45", "a.a", "." ] } ]
PMC11095939	ChIP-seq and mRNA-seq data were submitted to the GEO repository under accession numbers GSE227727 and GSE227723.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChIP-seq", "and", "mRNA-seq", "data", "were", "submitt...
PMC11740508	E final tumor images for TM00091; #, animal died 2 days before tumor harvests, tumor was unrecoverable Talazoparib plus decitabine treatment significantly impair growth of BRCA mutant xenografts and PDX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	Post-exercise ADCCPlasma was 58% greater than post-exercise ADCCHI-FCS, with a trend towards a difference pre-exercise (p = 0.07), which may represent a synergy between ADCC and other mechanisms-of-action of daratumumab, such as complement-dependent cytotoxicity (CDC) (de Weers et al., 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	Despite these discoveries, the specific role of SMPDL3B in malignancies, particularly in the development of ovarian carcinoma, has remained largely unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Furthermore, we have previously reported that CLL induces a dramatic remodeling of tumor microenvironment, notably leading to the accumulation of highly immunosuppressive Tregs (Wierz et al., Blood, 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627060	At each stage, NPs were reconstituted in approximately 10 mL of deionized water and underwent 5 min of ultrasonication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "each", "stage", ...
PMC6024716	Plates were incubated overnight in a humidified incubator at 37 °C, 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "were", "incubated", "overnight", "in", "a", ...
PMC7823217	However, the most challenging aspects of creating heterogenous cancer constructs include: prompt isolation of sufficient number of cells, maintenance of these heterogeneous group of primary cells, subsequent bioprinting and rapid testing with drug candidates that will enable selection of the most appropriate chemothera...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597291	Then, the reaction mixture was dialyzed against excess D-H2O for 24 h in a dialysis membrane (MWCO 12 kDa) in order to remove the organic solvent and non-entrapped PCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	Molecular–structural characteristics, such as hydrogen-(H)-bond donors, H-bond acceptors, or rotatable bonds are important for the pharmacokinetics and pharmacodynamics of drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11612626	OT-1 mice contain a transgenic TCR that recognizes Ova residues 257 to 264 in the context of the H2K class-I molecule interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OT-1", ...
PMC11321678	Then, we examined the motifs that were enriched in marker peaks within each cluster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "we", "examined", "the", "motifs", "that", ...
PMC11626627	Further biochemical and molecular biology experiments are required to elucidate the precise mechanisms underlying the interaction between ERβ and TWIST1, including specific signaling pathways and protein modifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11798926	The following day, membranes were washed three times with TBST and incubated with the following secondary antibodies: Goat α-mouse Azure 700 (Azure Biosystems Cat# AC2129, RRID:AB_3331665, 1:1,000) and Goat α-Rat H + L Alexa 488 (Jackson ImmunoResearch Labs Cat# 112–545-167, RRID:AB_2338362; 1:500, for use on input sam...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11334037	The sections were observed with a microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sections", "were", "observed", "with", "a", "microscope", "." ] } ]
PMC11757230	However, a key finding of this study, which raises concerns about the safety of MSC-based therapy, is that cADSCs promoted Ema cell proliferation through secreted factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11247842	In recent years, key initiatives have been underway to improve annotation of the cattle genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "key", "initiatives", ...
PMC9429973	Summary/Conclusion: The results of the study suggests that TNF-α (-308) GA genotype, IFN-γ (+874) TT genotype, IL6 (-174) GG genotype, TGF-β1 (T10 / C10) TT genotype, TGF-β1 (C25 / G25) GC genotype, IL10 (-1082) GG genotype, IL10 (-819) CC genotype, IL10 (-592) CC genotype, TGF-β1 (T / C10, C / G25) gene “TCGC, CCGG, T...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835762	PGA-co-PDL and the PEGylated variation have shown good propensity to be formulated into nanoparticles (NPs) or microparticles (MPs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PGA-co-PDL", ...
PMC6222726	Their flowers are small, almost always unisexual, three- to six-merous.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Their", "flowers", "are", "small", ",", "almost", "always", "unisexual", ",", ...
PMC11306331	Our results also raise an open question: what is the mechanism by which MBP achieves its solubilizing effects?	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "also", "raise",...
PMC11472639	Anaerobic threshold was determined – independently by two researchers – using the V-slope method (Beaver et al., 1986) and confirmed through visual inspection of and .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	MB-CM group (treatment of IL-1β-induced Caco-2 cells with CM of menstrual blood–derived stem cells) 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MB-CM", "group", "(", "t...
PMC11779960	Similarly, WTS datasets, such as the one used in Iyer et al., suffer from low coverage, impacting data quality and reliability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11750712	While AUTO4 can concomitantly target nonmalignant TRBC1 T cells, T cells expressing TRBC2 may be spared, preserving functional cellular immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "AUT...
PMC11588085	To better understand the role of XIST in ovarian cancer cell stemness, we examined XIST expression in ovarian cancer cell lines through the CCLE (Cancer Cell Line Encyclopedia) database (40).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "...
PMC10874773	12Possible biosynthetic pathways of seco-prezizaane-type sesquiterpenes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "12Possible", "biosynthetic", "pathways", "of", "seco-prezizaane-type", "sesquiterpenes", "." ] } ]
PMC6268318	In studies evaluating its antibacterial activity, the extracts used were obtained with different solvents (ethanol, chloroform, methanol or water).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11098378	Briefly, at indicated times post infection/transfection, cells were washed in PBS, pelleted by brief centrifugation, and lysed in reporter lysis buffer (Promega; S4 Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Further studies are needed to clarify how the downregulation of proteins is related to the up- or downregulation of several signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "s...
PMC11411131	Additionally, although Krab-Sec 3 could inhibit activity, this reduction was not superior to that achieved by Krab-Sec.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "although", "...
PMC11513011	In this study, we believe that the difference in drug sensitivity between T24 and 5637 is due to the presence or absence of Ras mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11765879	After 48 h, the angiogenesis bed of each embryo was examined using a Stemi 305 stereo microscope (Carl-Zeiss, Oberkochen, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11144382	Since there is no human ortholog for the mouse specific Eif2s3y gene, it was not considered for further analysis in relation to MSS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11648299	For the nationwide study, a cohort of patients with DD was generated using the NPR and the same ICD-code as above during the time period of January 1, 2001 to December 31, 2020.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9479186	In SK-HEP-1 cells, after 24 h of culture, the migration rate of cells in the Lv-shNDUFC1 infection group decreased by 71% (P < 0.001).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	In this step, clean data were obtained by removing reads containing adapter and trimming low-quality base with Trimmomatic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "step", ",", "...
PMC9119314	The residue was acidified with citric acid solution (10% /v in ethanol) and then refluxed with the addition of sufficient ethanol to just dissolve the residue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	Relationship of circUSP10 expression with clinicopathological features in liver cancer patients. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relationship", "of", "circUSP10", "expression", "with", "clinicopathological", "features", ...
PMC9895440	Fresh SNX9 KO and control CD8+ human T cells were generated by electroporation as described above but without TCR transduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fresh", "SNX9", "...
PMC6892818	This provides for the first time evidence for a tumour cell-specific pro-apoptotic effect in RCC, as well as adding support to previous observations that mCD40L is non-apoptotic in normal human uro-epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752740	CFZ (CFZ) was obtained from AdooQ BioScience (CA, USA) and prepared as an initial stock by dissolving 2.88 mg of the compound in 2 ml of dimethyl sulfoxide (DMSO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991	Primary antibodies were added to the cells diluted in 1% FCS in 0.3% Triton-X100-PBS: in 1:50 dilution for 1 h at RT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Methods: The study group comprised 17 individuals with LC-MBL and 14 with HC-MBL. “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "study", "group", "comprised", "17", ...
PMC9559528	The lesions of EM are usually triggered by HSV or M. pneumoniae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lesions", "of", "EM", "are", "usually", "triggered", "by", "HSV", "...
PMC11348300	While HS values consistently reach equilibrium, particularly after CO2 breathing, leading to saturation indicative of complete hypoxia, pO2 values from PdG4 exhibit a distinct pattern, never fully equilibrating.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306019	Combination index (CI) of 1,3,6-triGG and PGG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combination", "index", "(", "CI", ")", "of", "1,3,6-triGG", "and", "PGG", "." ] } ]
PMC11127909	It has both physiological and pathological meanings for cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "both", "physiological", "and", "pathological", "meanings", "for", "cells", "." ] } ]
PMC10588957	Autophagy is closely related to human health and disease (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autophagy", "is", "closely", "related", "to", "human", "health", "and", "disease...
PMC9119314	A group of two untreated control animals was included at each dose level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "group", "of", "two", "untreated", "control", "animals", "was", "...
PMC11587606	Protein samples were subjected to SDS-PAGE and transferred to PVDF membranes (Millipore, Bedford, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "samples", "were",...
PMC11740207	Telomerase levels are low in normal somatic cells, resulting in telomere shortening after a finite number of divisions, which triggers cellular aging or programmed cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The role of arginine in disordered erythropoiesis was evaluated in human HSPC with shRNA-mediated downregulation of RPS19 and RPL11, as well as in del(5q)-MDS progenitors and in murine haploinsufficient Rps14 progenitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	BLI and luminescence signal intensity of the orthotopic tumor model in the control and phenylalanine-deprivation groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BLI", "and", "luminescence", "signal", "intensity...
PMC11705067	Based on the above results, we validated the protein expression of FDX1 and DLAT in five matched normal and ccRCC clinical samples, and found that their protein expressions were poorly expressed in ccRCC tissues compared to adjacent tissues (Fig. 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11548041	These aptamers have high binding affinity to and demonstrate specificity for EpCAM expressed on CCA tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "aptamers", "have", "high", "binding", ...
PMC11519788	Methods: UBC cell lines (5637, T24 and SW780), along with a monocytic cell line (U937) capable of differentiating into macrophage, were used in a co-culture system for cell proliferation and stemness by MTT, sphere formation assays.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11696576	Oxidation of 12a–j to aldehydes with NaOCl in the presence of TEMPO and subsequent treatment with TBDMSCN and KCN led to cyanohydrins 13a–j. Thiazolines 14a–j were synthesized by reaction of the cyano group of 13a–j with either methyl or ethyl cysteinate, while aromatization to 15a–j was achieved by oxidation with BrCC...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638288	Furthermore, this study also identified three important fungal ligands for NK receptors, namely Candida albicans adhesins Epa1, Epa6, and Epa7, and demonstrated the essential role of the interaction between Epa1, Epa6, and Epa7 with NKp46/NCR1 in the clearance of Candida albicans in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	F, G Quantification of dissolution efficiency for FET family full-length proteins from microscopy data by calculating the change in the coefficient of variation and enrichment after 3 min blue light stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Finally, to better elucidate the role of DPRs in C9ALS/FTD, both viral and transgenic mouse models have been developed overexpressing codon-optimized constructs to synthesize only one specific DPR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10196713	OC is a carcinoma with a poor prognosis that is often detected at an advanced stage with peritoneal dissemination that becomes refractory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OC", "is", ...
PMC11453018	Results are presented as fold differences compared to the control (untreated group at 24 hours) (n = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "a...
PMC6600592	m.p.	[ { "tags": [ "O", "O" ], "tokens": [ "m.p", "." ] } ]
PMC11775197	In addition, IFC-305, an adenosine derivative, inhibits methylation of the PPARγ promoter and up-regulates PPARγ expression, thereby reducing the risk of radiation-induced intestinal toxicity in colon cancer treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One patient received a maximum NK cell dose of 5x10 cells/kg, 2 patients 1x10 cells/kg and 3 5x10 cells/kg/BW.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "received",...
PMC9429973	Median age was 66 years (range, 39-78).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "age", "was", "66", "years", "(", "range", ",", "39", "-", ...
PMC9429973	of Emergency and Organ Transplantation, University of Bari, Bari; Candiolo Cancer Institute, FPO-IRCCS, Candiolo; U.O.C. Ematologia, P.O. “Andrea Tortora”, Pagani; Department of Medicine, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy Background: Optimal consolidation for young R/...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	During the follow-up period, no patient reported progression of existing comorbidities or the development of new ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "follow-up", "period", ...
PMC11676674	These metabolites have been reported to have a health benefit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "metabolites", "have", "been", "reported", "to", "have", "a", "health", "benefit", ...
PMC2614416	This appears to be a survival mechanism which confers powerful selective advantage to cancer cells in an effort to maximize their proliferative potentials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11216402	The list of all 1639 human TFs was retrieved from http://humantfs.ccbr.utoronto.ca/download.php (version 1.01) (Lambert et al. 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "list", "of...
PMC11486946	c Effects of compounds on EGFR mobility were evaluated using the MSDΔt ratio in which Δt provided optimal duration to obtain the best Z’-factor value in each well plate (Supplementary Fig. 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At the time of diagnosis, only 1 patient was classified as having single-system LCH, and 35 patients were classified as having multisystem (MS) LCH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	These steps will be crucial in harnessing the therapeutic potential of Ficus plants for safe and effective use in modern medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "steps", ...
PMC10174970	Fourthly, PAAD cell lines cannot mimic the real immune environment in primary pancreatic tumors because not only tumor cells but also stroma, fibroblast and various immune cells are present in tumors (24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11658074	f HE, Masson, Sirius Red, immunofluorescent and situ dihydroethidium red fluorescence staining to determine epidermal thickness, dermis thickness, collagen deposition, SA-β-gal expression and ROS levels in the four groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11204465	Mycotoxins are toxic secondary metabolites synthesised by specific fungi belonging to Aspergillus, Alternaria, Fusarium and Penicillium species.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mycotoxins", "are", "toxic", "sec...
PMC11476106	The PDX73 cell line, a short-term culture (established and frozen in 2015) with no more than 13 passages in 2D culture, may have better retained the characteristics of the original tumor with a less variability in VN release and cellular expression, and more homogeneous and diffuse staining in 2D and 3D cultures.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	One EBV latency protein, latency membrane protein 2A (LMP2A), is expressed in multiple latency phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "EBV", "latency", "protein"...
PMC11672142	These concentrations are well above the GI50/IC50 and TGI values of DefNEtTrp against all of the cancer cells examined in this work, indicative of the compound being highly selective for cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	2 days after stimulation, 10mio of the splenocytes and lymphocyte mixture was collected per condition, spun at 90 g for 10 min and then resuspended in 100ul P4 nucleofection buffer, the Cas9-RNPs and electroporated with the CM137 program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	Four visual fields were randomly selected under the microscope to count the cells passing through the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "visual", "fields", "were", "randomly", ...
PMC11785489	Instead, we used T cell state annotations provided by the authors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Instead", ",", "we", "used", "T", "cell", "state", "annotations", "provided", ...

PMC7057940

The Carl Zeiss fluorescence microscope (Axio-Scope A1) with image capture software was used for the evaluation.

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PMC11659734

The metabolic activation was provided by rat liver homogenate (S9 fraction).

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PMC9429973

Treatment is continued until PD or unacceptable toxicity or for a maximum of 1.5 years.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "is", "continued", "until", "PD", "or", "unacce...

PMC9429973

Patients with PG-TCL generally exhibited poor prognosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "PG-TCL", "generally", "exhibited", "poor", "prognosis", "." ] } ]

PMC9917080

At the same time, in astrocytes of the cerebral cortex, sorafenib, selenium nanoparticles, and the selenium-sorafenib nanocomplex did not cause cell death either after 24 or after 48 h of incubation, which indicates the target orientation of the studied agents on cancer cells.

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PMC11792766

Additionally, various other solvents and food simulants have been used in literature for the preparation of samples, including 95% v/v ethanol, isooctane, methanol, n‐heptane, and ethane (Bradley et al., 2008, 2010; Groh & Muncke, 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

When analyzed by BOR, the median percentage change (decrease) from BL in CS dose was similar in RUX and BAT responders but was smaller in BAT vs RUX nonresponders (Figure).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Group 1 (n=195) had known adverse risk cytogenetics (Grimwade et al, Blood 2010,116, 354) and were randomised at diagnosis between 4 courses of CPX-351 and 2 courses of FLAG-Ida followed by MACE/MidAC consolidation.

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PMC10362265

The complex structure illustrates the mobile regions colored red. (

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PMC10713411

Gene expression and coefficients derived from LASSO Cox regression were used for the establishment of the formula for risk score computation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", ...

PMC5034105

The gradual onset of CPE in most of these cell lines at 3 d.p.i.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gradual", "onset", "of", "CPE", "in", "most", "of", ...

PMC9780037

For simplicity, some of the elements of these delivery systems were omitted.

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PMC10818573

In an additional assessment, the reaction time was fixed at 15 min for the initial reaction temperatures tested, including 25 °C, 35 °C, and 45 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11679326

Despite limited data on their structure and properties, their ability to interact with mammalian immunoglobulins and recognize aberrant glycosylation on human cells suggests significant potential for these molecules to develop new biotechnological and biomedical technologies .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10932641

The Wnt-β-catenin system is an evolutionarily conserved signaling pathway that plays a crucial role in regulating embryonic development, cell differentiation, proliferation, and adult stem cell homeostasis (34,35).

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PMC11753949

384–473, partially overlapped with a 45 a.a.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "384–473", ",", "partially", "overlapped", "with", "a", "45", "a.a", "." ] } ]

PMC11095939

ChIP-seq and mRNA-seq data were submitted to the GEO repository under accession numbers GSE227727 and GSE227723.

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PMC11740508

E final tumor images for TM00091; #, animal died 2 days before tumor harvests, tumor was unrecoverable Talazoparib plus decitabine treatment significantly impair growth of BRCA mutant xenografts and PDX.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11472639

Post-exercise ADCCPlasma was 58% greater than post-exercise ADCCHI-FCS, with a trend towards a difference pre-exercise (p = 0.07), which may represent a synergy between ADCC and other mechanisms-of-action of daratumumab, such as complement-dependent cytotoxicity (CDC) (de Weers et al., 2011).

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PMC11082662

Despite these discoveries, the specific role of SMPDL3B in malignancies, particularly in the development of ovarian carcinoma, has remained largely unknown.

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PMC9429973

Furthermore, we have previously reported that CLL induces a dramatic remodeling of tumor microenvironment, notably leading to the accumulation of highly immunosuppressive Tregs (Wierz et al., Blood, 2018).

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PMC11627060

At each stage, NPs were reconstituted in approximately 10 mL of deionized water and underwent 5 min of ultrasonication.

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PMC6024716

Plates were incubated overnight in a humidified incubator at 37 °C, 5% CO2.

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PMC7823217

However, the most challenging aspects of creating heterogenous cancer constructs include: prompt isolation of sufficient number of cells, maintenance of these heterogeneous group of primary cells, subsequent bioprinting and rapid testing with drug candidates that will enable selection of the most appropriate chemothera...

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PMC11597291

Then, the reaction mixture was dialyzed against excess D-H2O for 24 h in a dialysis membrane (MWCO 12 kDa) in order to remove the organic solvent and non-entrapped PCT.

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PMC9841531

Molecular–structural characteristics, such as hydrogen-(H)-bond donors, H-bond acceptors, or rotatable bonds are important for the pharmacokinetics and pharmacodynamics of drugs.

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PMC11612626

OT-1 mice contain a transgenic TCR that recognizes Ova residues 257 to 264 in the context of the H2K class-I molecule interaction.

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PMC11321678

Then, we examined the motifs that were enriched in marker peaks within each cluster.

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PMC11626627

Further biochemical and molecular biology experiments are required to elucidate the precise mechanisms underlying the interaction between ERβ and TWIST1, including specific signaling pathways and protein modifications.

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PMC11798926

The following day, membranes were washed three times with TBST and incubated with the following secondary antibodies: Goat α-mouse Azure 700 (Azure Biosystems Cat# AC2129, RRID:AB_3331665, 1:1,000) and Goat α-Rat H + L Alexa 488 (Jackson ImmunoResearch Labs Cat# 112–545-167, RRID:AB_2338362; 1:500, for use on input sam...

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PMC11334037

The sections were observed with a microscope.

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PMC11757230

However, a key finding of this study, which raises concerns about the safety of MSC-based therapy, is that cADSCs promoted Ema cell proliferation through secreted factors.

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PMC11247842

In recent years, key initiatives have been underway to improve annotation of the cattle genome.

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PMC9429973

Summary/Conclusion: The results of the study suggests that TNF-α (-308) GA genotype, IFN-γ (+874) TT genotype, IL6 (-174) GG genotype, TGF-β1 (T10 / C10) TT genotype, TGF-β1 (C25 / G25) GC genotype, IL10 (-1082) GG genotype, IL10 (-819) CC genotype, IL10 (-592) CC genotype, TGF-β1 (T / C10, C / G25) gene “TCGC, CCGG, T...

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PMC6835762

PGA-co-PDL and the PEGylated variation have shown good propensity to be formulated into nanoparticles (NPs) or microparticles (MPs).

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PMC6222726

Their flowers are small, almost always unisexual, three- to six-merous.

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PMC11306331

Our results also raise an open question: what is the mechanism by which MBP achieves its solubilizing effects?

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PMC11472639

Anaerobic threshold was determined – independently by two researchers – using the V-slope method (Beaver et al., 1986) and confirmed through visual inspection of and .

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PMC11519077

MB-CM group (treatment of IL-1β-induced Caco-2 cells with CM of menstrual blood–derived stem cells) 1.

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PMC11779960

Similarly, WTS datasets, such as the one used in Iyer et al., suffer from low coverage, impacting data quality and reliability.

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PMC11750712

While AUTO4 can concomitantly target nonmalignant TRBC1 T cells, T cells expressing TRBC2 may be spared, preserving functional cellular immunity.

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PMC11588085

To better understand the role of XIST in ovarian cancer cell stemness, we examined XIST expression in ovarian cancer cell lines through the CCLE (Cancer Cell Line Encyclopedia) database (40).

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PMC10874773

12Possible biosynthetic pathways of seco-prezizaane-type sesquiterpenes.

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PMC6268318

In studies evaluating its antibacterial activity, the extracts used were obtained with different solvents (ethanol, chloroform, methanol or water).

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PMC11098378

Briefly, at indicated times post infection/transfection, cells were washed in PBS, pelleted by brief centrifugation, and lysed in reporter lysis buffer (Promega; S4 Table).

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PMC11767817

Further studies are needed to clarify how the downregulation of proteins is related to the up- or downregulation of several signaling pathways.

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PMC11411131

Additionally, although Krab-Sec 3 could inhibit activity, this reduction was not superior to that achieved by Krab-Sec.

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PMC11513011

In this study, we believe that the difference in drug sensitivity between T24 and 5637 is due to the presence or absence of Ras mutations.

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PMC11765879

After 48 h, the angiogenesis bed of each embryo was examined using a Stemi 305 stereo microscope (Carl-Zeiss, Oberkochen, Germany).

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PMC11144382

Since there is no human ortholog for the mouse specific Eif2s3y gene, it was not considered for further analysis in relation to MSS.

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PMC11648299

For the nationwide study, a cohort of patients with DD was generated using the NPR and the same ICD-code as above during the time period of January 1, 2001 to December 31, 2020.

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PMC9479186

In SK-HEP-1 cells, after 24 h of culture, the migration rate of cells in the Lv-shNDUFC1 infection group decreased by 71% (P < 0.001).

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PMC11770130

In this step, clean data were obtained by removing reads containing adapter and trimming low-quality base with Trimmomatic.

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PMC9119314

The residue was acidified with citric acid solution (10% /v in ethanol) and then refluxed with the addition of sufficient ethanol to just dissolve the residue.

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PMC10565698

Relationship of circUSP10 expression with clinicopathological features in liver cancer patients. *

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PMC9895440

Fresh SNX9 KO and control CD8+ human T cells were generated by electroporation as described above but without TCR transduction.

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PMC6892818

This provides for the first time evidence for a tumour cell-specific pro-apoptotic effect in RCC, as well as adding support to previous observations that mCD40L is non-apoptotic in normal human uro-epithelial cells.

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PMC11752740

CFZ (CFZ) was obtained from AdooQ BioScience (CA, USA) and prepared as an initial stock by dissolving 2.88 mg of the compound in 2 ml of dimethyl sulfoxide (DMSO).

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PMC10957991

Primary antibodies were added to the cells diluted in 1% FCS in 0.3% Triton-X100-PBS: in 1:50 dilution for 1 h at RT.

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PMC9429973

Methods: The study group comprised 17 individuals with LC-MBL and 14 with HC-MBL. “

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PMC9559528

The lesions of EM are usually triggered by HSV or M. pneumoniae.

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PMC11348300

While HS values consistently reach equilibrium, particularly after CO2 breathing, leading to saturation indicative of complete hypoxia, pO2 values from PdG4 exhibit a distinct pattern, never fully equilibrating.

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PMC11306019

Combination index (CI) of 1,3,6-triGG and PGG.

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PMC11127909

It has both physiological and pathological meanings for cells.

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PMC10588957

Autophagy is closely related to human health and disease (12).

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PMC9119314

A group of two untreated control animals was included at each dose level.

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PMC11587606

Protein samples were subjected to SDS-PAGE and transferred to PVDF membranes (Millipore, Bedford, MA, USA).

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PMC11740207

Telomerase levels are low in normal somatic cells, resulting in telomere shortening after a finite number of divisions, which triggers cellular aging or programmed cell death.

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PMC9429973

The role of arginine in disordered erythropoiesis was evaluated in human HSPC with shRNA-mediated downregulation of RPS19 and RPL11, as well as in del(5q)-MDS progenitors and in murine haploinsufficient Rps14 progenitors.

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PMC11365427

BLI and luminescence signal intensity of the orthotopic tumor model in the control and phenylalanine-deprivation groups. (

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PMC11705067

Based on the above results, we validated the protein expression of FDX1 and DLAT in five matched normal and ccRCC clinical samples, and found that their protein expressions were poorly expressed in ccRCC tissues compared to adjacent tissues (Fig. 2D).

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PMC11548041

These aptamers have high binding affinity to and demonstrate specificity for EpCAM expressed on CCA tumor cells.

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PMC11519788

Methods: UBC cell lines (5637, T24 and SW780), along with a monocytic cell line (U937) capable of differentiating into macrophage, were used in a co-culture system for cell proliferation and stemness by MTT, sphere formation assays.

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PMC11696576

Oxidation of 12a–j to aldehydes with NaOCl in the presence of TEMPO and subsequent treatment with TBDMSCN and KCN led to cyanohydrins 13a–j. Thiazolines 14a–j were synthesized by reaction of the cyano group of 13a–j with either methyl or ethyl cysteinate, while aromatization to 15a–j was achieved by oxidation with BrCC...

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PMC11638288

Furthermore, this study also identified three important fungal ligands for NK receptors, namely Candida albicans adhesins Epa1, Epa6, and Epa7, and demonstrated the essential role of the interaction between Epa1, Epa6, and Epa7 with NKp46/NCR1 in the clearance of Candida albicans in vivo .

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PMC11306331

F, G Quantification of dissolution efficiency for FET family full-length proteins from microscopy data by calculating the change in the coefficient of variation and enrichment after 3 min blue light stimulation.

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PMC11001582

Finally, to better elucidate the role of DPRs in C9ALS/FTD, both viral and transgenic mouse models have been developed overexpressing codon-optimized constructs to synthesize only one specific DPR.

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PMC10196713

OC is a carcinoma with a poor prognosis that is often detected at an advanced stage with peritoneal dissemination that becomes refractory.

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PMC11453018

Results are presented as fold differences compared to the control (untreated group at 24 hours) (n = 6).

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PMC6600592

m.p.

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PMC11775197

In addition, IFC-305, an adenosine derivative, inhibits methylation of the PPARγ promoter and up-regulates PPARγ expression, thereby reducing the risk of radiation-induced intestinal toxicity in colon cancer treatment .

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PMC9429973

One patient received a maximum NK cell dose of 5x10 cells/kg, 2 patients 1x10 cells/kg and 3 5x10 cells/kg/BW.

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PMC9429973

Median age was 66 years (range, 39-78).

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PMC9429973

of Emergency and Organ Transplantation, University of Bari, Bari; Candiolo Cancer Institute, FPO-IRCCS, Candiolo; U.O.C. Ematologia, P.O. “Andrea Tortora”, Pagani; Department of Medicine, Division of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy Background: Optimal consolidation for young R/...

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PMC9429973

During the follow-up period, no patient reported progression of existing comorbidities or the development of new ones.

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PMC11676674

These metabolites have been reported to have a health benefit.

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PMC2614416

This appears to be a survival mechanism which confers powerful selective advantage to cancer cells in an effort to maximize their proliferative potentials.

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PMC11216402

The list of all 1639 human TFs was retrieved from http://humantfs.ccbr.utoronto.ca/download.php (version 1.01) (Lambert et al. 2018).

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PMC11486946

c Effects of compounds on EGFR mobility were evaluated using the MSDΔt ratio in which Δt provided optimal duration to obtain the best Z’-factor value in each well plate (Supplementary Fig. 3a).

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PMC9429973

At the time of diagnosis, only 1 patient was classified as having single-system LCH, and 35 patients were classified as having multisystem (MS) LCH.

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PMC11653533

These steps will be crucial in harnessing the therapeutic potential of Ficus plants for safe and effective use in modern medicine.

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PMC10174970

Fourthly, PAAD cell lines cannot mimic the real immune environment in primary pancreatic tumors because not only tumor cells but also stroma, fibroblast and various immune cells are present in tumors (24).

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PMC11658074

f HE, Masson, Sirius Red, immunofluorescent and situ dihydroethidium red fluorescence staining to determine epidermal thickness, dermis thickness, collagen deposition, SA-β-gal expression and ROS levels in the four groups.

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PMC11204465

Mycotoxins are toxic secondary metabolites synthesised by specific fungi belonging to Aspergillus, Alternaria, Fusarium and Penicillium species.

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PMC11476106

The PDX73 cell line, a short-term culture (established and frozen in 2015) with no more than 13 passages in 2D culture, may have better retained the characteristics of the original tumor with a less variability in VN release and cellular expression, and more homogeneous and diffuse staining in 2D and 3D cultures.

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PMC11012313

One EBV latency protein, latency membrane protein 2A (LMP2A), is expressed in multiple latency phenotypes.

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PMC11672142

These concentrations are well above the GI50/IC50 and TGI values of DefNEtTrp against all of the cancer cells examined in this work, indicative of the compound being highly selective for cancer cells.

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PMC9895440

2 days after stimulation, 10mio of the splenocytes and lymphocyte mixture was collected per condition, spun at 90 g for 10 min and then resuspended in 100ul P4 nucleofection buffer, the Cas9-RNPs and electroporated with the CM137 program.

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PMC11300639

Four visual fields were randomly selected under the microscope to count the cells passing through the membrane.

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PMC11785489

Instead, we used T cell state annotations provided by the authors.

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