OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11506670	Moreover, comparing the GDP-binding affinities, NRAS G48C, Q43K, and E37K all have less negative ΔG values, indicating a weaker binding affinity compared to the wild-type version.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	After 24 hours, different concentrations of Sora (0/20 μM) were added and cultured for 48 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "hours", ",", ...
PMC11470999	Penfluridol (PF) inhibits melanoma cells growth and metastasis in a CIP2A‐dependent manner. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Penfluridol", "(", "PF", ")", "inhibits", "melanoma", "cell...
PMC9429973	Management involves both controlling hemostasis and eradication of the inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Management", "involves", "both", "controlling", "hemostasis", "and", "eradication", "of", "the", ...
PMC9429973	The safety of polatuzumab vedotin and platinum-based therapy combinations must be considered as both are associated with neuropathy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "safety", "of", "polatuzumab", "...
PMC11092382	Lupus nephritis is a complication of the autoimmune disease systemic lupus erythematosus (Anders et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lupus", "nephritis", "is", "a", ...
PMC9812014	In a separate work by these researchers, another alkaloid called Sophaline-F was identified and showed 53.8% inhibition of the HBsAg secretion at a concentration of 0.035 mM compared to an inhibitory rate of 35.7% for lamivudine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	This result has not been replicated in NSCLC cell lines where only MYEOV RNA expression was observed (Fang et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11594074	Furthermore, DNMT inhibitors promoted NK cell-mediated cytotoxicity in tumors, which should be considered an additional mechanism of action.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "DNMT", ...
PMC11627060	These values indicate the electrostatic stability and surface charge characteristics of the NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "values", "indicate", "the", "electrostatic", "stability", "and", "...
PMC11753435	By varying the amount of noise and the number of real peptides sampled, we generate an arbitrarily large set of biologically viable de novo peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Data were analyzed with GemStone using its unique highly automated approach to characterizing normal cells in bone marrow based on a template model designed specifically for data generated with this panel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	Moreover, it is known that DNA repair can occur already during mitosis, which can lead to subsequent genetic instability, cell death, or mutations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	HGAL-mediated engagement of BCR-activated PDZ-RhoGEF pathways to DLBCL and Burkitt lymphoma cell cytoskeletal remodeling, including direct HGAL–cytoskeletal interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HG...
PMC11377827	Immunoblot is representative of three biological replicates. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoblot", "is", "representative", "of", "three", "biological", "replicates", ".", "(" ] } ]
PMC9429973	Non-malignant diagnoses were heterogeneous and included granulomatous disease including sarcoid (19/311) and infection/reactive causes (30/311).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Non-malignant", "diagnoses", "were", ...
PMC11683240	Third and fourth, PT was preincubated on cells for 15 min at 37 °C and was either present in the medium while α1AT or solvent control were added or washed away before adding α1AT or water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	In (B) the CSI‐related signal, acquired at 3.7 ppm, is displayed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "(", "B", ")", "the", "CSI‐related", "signal", "...
PMC11143482	injection of HOS-143B cells into the NSG mice, lung metastases were detected in (C) and (D) bone lesion upon 3 × 10 of cancer cells inoculated into the mice (magnification 20×).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Although RFC also has a high expression in NSCLC and MPM cells and tissues (Giovannetti et al., 2008; 2017), it does not play a role in the antitumor activity of PMX, possibly because in the tumor microenvironment, the pH is relatively low and RFC will be inactive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: 146 pts were randomized: 72 to IVO+AZA; 74 to placebo+AZA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "146", "pts", "were", "randomized", ":", "72", ...
PMC9412887	Therefore, there is great interest in developing combined strategies to improve NK cell immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "great", "interest", "in", ...
PMC9429973	TET2 SNP I1762V influenced the concomitant or reciprocal mutations in AML patients; I1762V was closely associated with the prognosis of AML patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TET2", ...
PMC11555465	In extreme situations, toxoplasmic encephalitis may potentially result in death (11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "extreme", "situations", ",", "toxoplasmic", "encephalitis", "may...
PMC7519871	3D and (B) 2D poses of BA with Protein kinase B (AkT) PDB ID: 1GZK. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "and", "(", ...
PMC11637284	The exact stoichiometry of the TAC subunits within the structure remains unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exact", "stoichiometry", "of", "the", "TAC", "subunits", "within", "the",...
PMC8996378	All the compounds displayed a significant effect on inhibiting ABCB1 efflux-pump activity compared with that of the positive control verapamil (FAR = 21.28 at 20 μM) (Ferreira et al., 2005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	Briefly, transduced TZM-bl cells were seeded in a 35-mm glass dish with a 14-mm bottom well (Cellvis) at 8,000 cells per well and incubated for 2 days at 37°C in 5% CO2.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	Taken together, these data suggest that transgene expression is a dominant determinant of qP in most clonal cell lines in this study, with higher gene copy number giving rise to higher mRNA levels and higher protein abundance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665584	Krt6b itself had no proximal PITX1 peaks but was mildly enriched for H3K4me3, suggesting that PITX1 may function distally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Krt6b", "itself", "had", ...
PMC11754784	Channels from left to right: Cy5 channel, TAMRA channel, FAM channel, bright-field overlay channel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Channels", "from", "left", "to", "righ...
PMC11684269	In the process of exerting immune function, T cell subsets undergo flexible metabolic reprogramming to meet bioenergetic demands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "process", "of", ...
PMC3019555	However, the contribution of different P-body components in this process is not well understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "contribution", "of", "different", "P...
PMC11740573	As it turned out, calcitriol treatment pre- or post-bacterial stimulation of vaginal epithelial cells significantly decreased the levels of IL-6 and IL-1β compared to cells stimulated only with bacteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	Table 3 summarizes the state-of-the art animal models used in CHIKV studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "3", "summarizes", "the", "state-of-the", "art", "animal", "models", "us...
PMC11746948	Recombinant lentiviral particles were produced by transfecting the plasmids into 293T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "Recombinant", "lentiviral", "particles", "were", "produced", "by", ...
PMC9429973	Results: So far, 40 clinical specimens have been subjected to Lymph3Cx testing in the MDAZL Laboratory with the following results: PMBL: 19 (47.5%); DLBCL: 15 (37.5%); Unclear: 5 (12.5%); Failed QC: 1 (2.5%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	The resulting long-range amplicon sequencing data are analysed with our ExCas-Analyzer and the frequencies of small mutations and large deletions are calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resul...
PMC11206502	Increased expression of BCL-2 is present in various types of tumors, including bladder cancer, supporting its tumorigenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "expression", "of", "...
PMC11243198	Cells were incubated with the Hoechst dye for 45 min at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated", "with", "the", "Hoechst", "dye", "f...
PMC11496728	The above data were from three independent experiments, when P < 0.05, the difference is statistically significant, compared with CHO-WT, P < 0.05, P < 0.01, P < 0.001, **P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Fig. 3Alx3-deficient mice show altered energy expenditure and food intake, but not body weight A-E) Indirect calorimetry measurements showing O2 consumption, CO2 production, RER, energy expenditure and locomotor activity values corresponding to a complete 24-hour cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Peptides were prepared in MST buffer containing 0.05% (v/v) Tween-20 (Sigma, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptides", "were", "prepared", "in", "MST", ...
PMC10297204	In vitro, measurement of cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cell Proliferation/Viability Assay Kit (R&D Systems) according to the manufacturer’s specifications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8806312	Using the ‘ggpubr’ and ‘pheatmap’ packages generated boxplots and heatmaps, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "‘", "ggpubr", "’", "and", "‘", ...
PMC9429973	However, patients are still found to develop VTE while on anticoagulation and the prevalence of VTE in COVID-19 patients on ECMO is still unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11774251	These are crucial mechanisms for mitigating aberrant keratinocyte proliferation in psoriasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "are", "crucial", "mechanisms", "for", "mitigating", "aberrant", "keratinocyte", "p...
PMC10858941	β-actin was used as a loading control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-actin", "was", "used", "as", "a", "loading", "control", "." ] } ]
PMC11472569	Furthermore, designing effective therapies to block EV-mediated MDR presents technical difficulties due to the need for precise molecular targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "designin...
PMC9429973	The proportion of patients receiving “holding” therapy, defined as lymphoma treatment between indication-to-CAR and apheresis, was comparable between EU and US centers (22% vs. 27%, p=0.32).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	To determine whether the effectors of the COL11A1 signaling, Src, Akt, and AMPK, also play a role in upregulating FASN in ovarian cancer cells, we blocked these signaling molecules using pharmacological inhibitors and measured the expression of FASN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11658074	Furthermore, AT-EVs increased NIH3T3 cell proliferation more rapidly than ADSC-EVs did at 24 h post-UVB irradiation, suggesting that AT-EVs may be absorbed by cells more quickly than ADSC-EVs are, thereby exerting their effects more efficiently (Fig. 3i).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222726	It inhibited the carrageenan-induced rat paw edema, in a dose- and time-dependent manner (three hours = 9.55%, five hours = 34.37%, and seven hours = 35.6%) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Two other SF3B1 mutated patients showing disease progression to AML harbored MECOM rearrangements when MDS was diagnosed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "other", "SF3B1", "mutated", "patients", ...
PMC10936243	It is not an urban area.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "not", "an", "urban", "area", "." ] } ]
PMC11805741	This association is clear from the observations that an adequate content of consumed CTDs may inhibit the process of initiation, progression, and metastasis of cancer (Starska-Kowarska 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	We then treated total cellular RNA with RNase R. We conducted qRT-PCR (Fig. 1E), which showed that USP10, the linear parent gene of circUSP10, had significantly decreased expression and circUSP10 expression remained unchanged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	For instance, Grandis et al used 3D multicellular DU-145 prostate cancer cell line based spheroids that could effectively simulate the prostate tumor microenvironment to evaluate the cytotoxic effects of ruthenium complexes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	MDAAs exhibit kinds of structurally unique frameworks and a variety of promising bioactivities, and so these natural products have attracted extensive attention from synthetic chemists.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10852540	RA: rosmarinic acid; DOX: doxorubicin; OVCAR3: ovarian adenocarcinoma cell line; HaCaT: human skin keratinocyte cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O" ], ...
PMC9429973	78% of patients already required transfusion at diagnosis and 55% of all patients received supportive care only.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "78", "%", "of", "patients", ...
PMC11766309	In adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), colon adenocarcinoma (COAD), kidney chromophobe (KICH), kidney clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), ovarian serous c...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	The normal mode analysis (NAM) and interaction entropy (IE) methods are considered to calculate the entropy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "normal", "mode", ...
PMC9429973	In addition, exquisite sensitivity of NOTCH1-mutant and SF3B1-mutant cell lines, contrary to their wild-type counterparts, was revealed towards the inhibitors of various hormone receptors or inhibitors of 20S proteasome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No SAEs assessed were deemed to be related to lilotomab and Betalutin®, by the investigators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "SAEs", "assessed", "were", "deemed", ...
PMC10024132	Unlike typical monoclonal antibodies (mAbs), it does not have an Fc domain and therefore is not protected by the neonatal Fc receptor-mediated recycling process from non-specific catabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11708541	Moreover, it was demonstrated that both dopamine depletion in the striatum and methyl-phenyl-tetrahydropyridine (MPTP) induced neuronal death in the sensory neurons were prevented by 4-AP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: 1) We established the in vitro model with locally distributed MET, and the MENK can efficiently eliminate the MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11521786	However, the contribution of the cellular response potentially induced by this vaccine to its antitumor effect cannot be ruled out, although it remains to be demonstrated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	H&E staining images of OS tissue from each mouse group Scale bars = 1 mm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H&E", "staining", "images", "of", "OS", "tissue", ...
PMC11736898	We observed a trend toward decreased proliferation with increasing levels of vitamin D (0–100 nM) after 24 h of treatment, although the differences in proliferation were not statistically significant (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	Breast cancer resistance protein (BCRP/ABCG2) has been described to be one of the main transporters at the blood–milk barrier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Breast"...
PMC9884169	Target cells were seeded in six-well plates and cultured in an incubator for 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Target", "cells", "were", "seeded", "in", "six-well", "plat...
PMC7868205	SEM and TEM are electron microscopic techniques used to study the morphology of nanomaterials at various magnifications.45,46 The representative images are presented in Figure 3A–D.Figure 2XRD pattern of the synthesized nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7612475	Therefore, to assess this, we initially determined whether SF3B1 depletion would have a deleterious impact on cell survival following the induction of DNA double-strand breaks (DSB) using two independent siRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11547972	An old study conducted in 1982, involving 175 cancer patients, did not report a clinical benefit of amygdalin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "old", "study", "...
PMC11597291	The outmost of the effect on G2 phase and cellular apoptosis was observed at 15 h after light onset (HALO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "outmo...
PMC11082662	P<0.5; , P<0.01 , P<0.001; ***, P<0.0001; N.S., not significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P<0.5",...
PMC9429973	The study is open for enrollment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "is", "open", "for", "enrollment", "." ] } ]
PMC10993311	The uterus undergoes intense vascularization due to the need for greater blood perfusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "uterus", "undergoes", "intense", "vascularization", "due", "to", "th...
PMC11682172	The passage of MDA-MB-231-B2M2 cells was less than for MDA-MB-231 and SK-BR-7.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "The", "passage", "of", "MDA-MB-231-B2M2", "cells", "was", "less",...
PMC11544122	Serial dilution (1:1) was performed from tubes #2 to #16.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serial", "dilution", "(", "1:1", ")", "was", "performed", "from"...
PMC9429973	Detection of acquired BTK and PLCy2 mutations on therapy is feasible and may herald clinical disease progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "acquired", "BTK", "and", ...
PMC7802142	Here, ReN-NV were revealed to have the capacity to promote DPC proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "ReN-NV", "were", "revealed", "to", "have", "the", "capac...
PMC4485786	Quantification of I-labeled NHS-IL12 showed 4- to 6-fold radionuclide enrichment in the tumors compared with the contralateral muscle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "I-labeled", "NHS-IL1...
PMC11721295	Mouse and human peptidylprolyl isomerase A and β-actin were used as housekeeping controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "and", "human", "peptidylprolyl", "isomerase", "A", "and", "β-actin...
PMC9917080	It is known that Ca ions as a second messenger regulate almost all cellular functions, including proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "known", "that", "Ca", ...
PMC11711663	Head and Neck Squamous Cell Carcinoma (HNSCC), which arises from the epithelial layers of the oral cavity, pharynx, and larynx, accounts for 90% of HNC cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like Staphylococcus aureus without disrupting beneficial flora.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	These results confirmed that VTE effectively inhibited the proliferation and migration of IL-1β induced cells after 24 and 48 h of incubation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "res...
PMC11546117	The apparent permeability coefficient (Papp) was calculated using Equation (3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "apparent", "permeability", "coefficient", "(", "Papp", ")", ...
PMC11387401	Limited dilution and Zeocin selection produced stable monoclonal cell lines that (without doxycycline induction) constitutively express a single 2xStrepTagII-TEV-3xFLAG-tagged MA, NC, or Tat protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300639	TCGA-KIRC dataset analysis and RT‒qPCR analysis were used to examine the pathways affected by RNF26 silencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TCGA-KIRC", "dataset", "analysis", "and", "RT‒qPCR", "...
PMC11129910	We examined mammary spindle cell carcinomas to corroborate our in vitro findings as they best exemplify the claudin-low, mesenchymal phenotypical breast tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11748618	Chromatin states of PBMCs from individuals of African (ENCFF863IVL) and European ancestry (ENCFF235OWS), as well as LCLs from individuals of African (ENCFF747OPJ) and European ancestry (ENCFF070KWN), were obtained from ENCODE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	Reduced expression of SerpinA12 in keratinocyte has been reported to decreased expression of the desmosomal proteins, cornified envelope proteins, and keratins (55) which are proteins that maintain the integrity of the epidermal barrier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730311	hαCGRP8-37N25K-C20DA-γGlu was identified as the most potent of the tested lipidated hαCGRP8-37 analogues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "hαCGRP8", "-", "37N25K-C20DA-γGlu", "was", "ident...
PMC11488203	To estimate the amount of taxol in these MSC-derived EVs/exosomes, extensive LC–MS/MS analyses in a previous work have demonstrated approximately 123 ± 0.7 nM taxol in the EV/exosome preparations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	In bafilomycin A1-treated samples, the odds ratio of genome release was reduced approximately two-fold in cytoplasm (OR = 0.47, 95% CI 0.28–0.78, SE = 0.26, z = 2.90, P = 0.0037) and about 15-fold in vesicles (OR = 0.063, 95% CI 0.028–0.144, z = 6.57, P < 0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Cell-directed delivery of CRISPR-Cas9 is an essential element for HIV-1 elimination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell-directed", "delivery", "of", "CRISPR-Cas9", "is", "an", "essential", "element", "for",...

PMC11506670

Moreover, comparing the GDP-binding affinities, NRAS G48C, Q43K, and E37K all have less negative ΔG values, indicating a weaker binding affinity compared to the wild-type version.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11772449

After 24 hours, different concentrations of Sora (0/20 μM) were added and cultured for 48 hours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "hours", ",", ...

PMC11470999

Penfluridol (PF) inhibits melanoma cells growth and metastasis in a CIP2A‐dependent manner. (

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PMC9429973

Management involves both controlling hemostasis and eradication of the inhibitor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Management", "involves", "both", "controlling", "hemostasis", "and", "eradication", "of", "the", ...

PMC9429973

The safety of polatuzumab vedotin and platinum-based therapy combinations must be considered as both are associated with neuropathy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "safety", "of", "polatuzumab", "...

PMC11092382

Lupus nephritis is a complication of the autoimmune disease systemic lupus erythematosus (Anders et al., 2020).

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PMC9812014

In a separate work by these researchers, another alkaloid called Sophaline-F was identified and showed 53.8% inhibition of the HBsAg secretion at a concentration of 0.035 mM compared to an inhibitory rate of 35.7% for lamivudine.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11319300

This result has not been replicated in NSCLC cell lines where only MYEOV RNA expression was observed (Fang et al., 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11594074

Furthermore, DNMT inhibitors promoted NK cell-mediated cytotoxicity in tumors, which should be considered an additional mechanism of action.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "DNMT", ...

PMC11627060

These values indicate the electrostatic stability and surface charge characteristics of the NPs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "values", "indicate", "the", "electrostatic", "stability", "and", "...

PMC11753435

By varying the amount of noise and the number of real peptides sampled, we generate an arbitrarily large set of biologically viable de novo peptides.

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PMC9429973

Data were analyzed with GemStone using its unique highly automated approach to characterizing normal cells in bone marrow based on a template model designed specifically for data generated with this panel.

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PMC11726848

Moreover, it is known that DNA repair can occur already during mitosis, which can lead to subsequent genetic instability, cell death, or mutations .

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PMC11518702

HGAL-mediated engagement of BCR-activated PDZ-RhoGEF pathways to DLBCL and Burkitt lymphoma cell cytoskeletal remodeling, including direct HGAL–cytoskeletal interactions.

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PMC11377827

Immunoblot is representative of three biological replicates. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoblot", "is", "representative", "of", "three", "biological", "replicates", ".", "(" ] } ]

PMC9429973

Non-malignant diagnoses were heterogeneous and included granulomatous disease including sarcoid (19/311) and infection/reactive causes (30/311).

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PMC11683240

Third and fourth, PT was preincubated on cells for 15 min at 37 °C and was either present in the medium while α1AT or solvent control were added or washed away before adding α1AT or water.

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PMC11604830

In (B) the CSI‐related signal, acquired at 3.7 ppm, is displayed.

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PMC11143482

injection of HOS-143B cells into the NSG mice, lung metastases were detected in (C) and (D) bone lesion upon 3 × 10 of cancer cells inoculated into the mice (magnification 20×).

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PMC11371747

Although RFC also has a high expression in NSCLC and MPM cells and tissues (Giovannetti et al., 2008; 2017), it does not play a role in the antitumor activity of PMX, possibly because in the tumor microenvironment, the pH is relatively low and RFC will be inactive.

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PMC9429973

Results: 146 pts were randomized: 72 to IVO+AZA; 74 to placebo+AZA.

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PMC9412887

Therefore, there is great interest in developing combined strategies to improve NK cell immunity.

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PMC9429973

TET2 SNP I1762V influenced the concomitant or reciprocal mutations in AML patients; I1762V was closely associated with the prognosis of AML patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TET2", ...

PMC11555465

In extreme situations, toxoplasmic encephalitis may potentially result in death (11).

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PMC7519871

3D and (B) 2D poses of BA with Protein kinase B (AkT) PDB ID: 1GZK. (

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PMC11637284

The exact stoichiometry of the TAC subunits within the structure remains unknown.

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PMC8996378

All the compounds displayed a significant effect on inhibiting ABCB1 efflux-pump activity compared with that of the positive control verapamil (FAR = 21.28 at 20 μM) (Ferreira et al., 2005).

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PMC8735881

Briefly, transduced TZM-bl cells were seeded in a 35-mm glass dish with a 14-mm bottom well (Cellvis) at 8,000 cells per well and incubated for 2 days at 37°C in 5% CO2.

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PMC11697065

Taken together, these data suggest that transgene expression is a dominant determinant of qP in most clonal cell lines in this study, with higher gene copy number giving rise to higher mRNA levels and higher protein abundance.

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PMC11665584

Krt6b itself had no proximal PITX1 peaks but was mildly enriched for H3K4me3, suggesting that PITX1 may function distally.

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PMC11754784

Channels from left to right: Cy5 channel, TAMRA channel, FAM channel, bright-field overlay channel.

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PMC11684269

In the process of exerting immune function, T cell subsets undergo flexible metabolic reprogramming to meet bioenergetic demands.

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PMC3019555

However, the contribution of different P-body components in this process is not well understood.

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PMC11740573

As it turned out, calcitriol treatment pre- or post-bacterial stimulation of vaginal epithelial cells significantly decreased the levels of IL-6 and IL-1β compared to cells stimulated only with bacteria.

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PMC8524093

Table 3 summarizes the state-of-the art animal models used in CHIKV studies.

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PMC11746948

Recombinant lentiviral particles were produced by transfecting the plasmids into 293T cells.

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PMC9429973

Results: So far, 40 clinical specimens have been subjected to Lymph3Cx testing in the MDAZL Laboratory with the following results: PMBL: 19 (47.5%); DLBCL: 15 (37.5%); Unclear: 5 (12.5%); Failed QC: 1 (2.5%).

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PMC11754094

The resulting long-range amplicon sequencing data are analysed with our ExCas-Analyzer and the frequencies of small mutations and large deletions are calculated.

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PMC11206502

Increased expression of BCL-2 is present in various types of tumors, including bladder cancer, supporting its tumorigenesis.

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PMC11243198

Cells were incubated with the Hoechst dye for 45 min at 37 °C.

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PMC11496728

The above data were from three independent experiments, when P < 0.05, the difference is statistically significant, compared with CHO-WT, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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PMC11335267

Fig. 3Alx3-deficient mice show altered energy expenditure and food intake, but not body weight A-E) Indirect calorimetry measurements showing O2 consumption, CO2 production, RER, energy expenditure and locomotor activity values corresponding to a complete 24-hour cycle.

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PMC11544122

Peptides were prepared in MST buffer containing 0.05% (v/v) Tween-20 (Sigma, cat.

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PMC10297204

In vitro, measurement of cell viability was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cell Proliferation/Viability Assay Kit (R&D Systems) according to the manufacturer’s specifications.

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PMC8806312

Using the ‘ggpubr’ and ‘pheatmap’ packages generated boxplots and heatmaps, respectively.

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PMC9429973

However, patients are still found to develop VTE while on anticoagulation and the prevalence of VTE in COVID-19 patients on ECMO is still unclear.

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PMC11774251

These are crucial mechanisms for mitigating aberrant keratinocyte proliferation in psoriasis.

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PMC10858941

β-actin was used as a loading control.

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PMC11472569

Furthermore, designing effective therapies to block EV-mediated MDR presents technical difficulties due to the need for precise molecular targeting.

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PMC9429973

The proportion of patients receiving “holding” therapy, defined as lymphoma treatment between indication-to-CAR and apheresis, was comparable between EU and US centers (22% vs. 27%, p=0.32).

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PMC7171147

To determine whether the effectors of the COL11A1 signaling, Src, Akt, and AMPK, also play a role in upregulating FASN in ovarian cancer cells, we blocked these signaling molecules using pharmacological inhibitors and measured the expression of FASN.

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PMC11658074

Furthermore, AT-EVs increased NIH3T3 cell proliferation more rapidly than ADSC-EVs did at 24 h post-UVB irradiation, suggesting that AT-EVs may be absorbed by cells more quickly than ADSC-EVs are, thereby exerting their effects more efficiently (Fig. 3i).

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PMC6222726

It inhibited the carrageenan-induced rat paw edema, in a dose- and time-dependent manner (three hours = 9.55%, five hours = 34.37%, and seven hours = 35.6%) .

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PMC9429973

Two other SF3B1 mutated patients showing disease progression to AML harbored MECOM rearrangements when MDS was diagnosed.

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PMC10936243

It is not an urban area.

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PMC11805741

This association is clear from the observations that an adequate content of consumed CTDs may inhibit the process of initiation, progression, and metastasis of cancer (Starska-Kowarska 2022).

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PMC10565698

We then treated total cellular RNA with RNase R. We conducted qRT-PCR (Fig. 1E), which showed that USP10, the linear parent gene of circUSP10, had significantly decreased expression and circUSP10 expression remained unchanged.

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PMC7823217

For instance, Grandis et al used 3D multicellular DU-145 prostate cancer cell line based spheroids that could effectively simulate the prostate tumor microenvironment to evaluate the cytotoxic effects of ruthenium complexes .

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PMC9436459

MDAAs exhibit kinds of structurally unique frameworks and a variety of promising bioactivities, and so these natural products have attracted extensive attention from synthetic chemists.

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PMC10852540

RA: rosmarinic acid; DOX: doxorubicin; OVCAR3: ovarian adenocarcinoma cell line; HaCaT: human skin keratinocyte cell line.

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PMC9429973

78% of patients already required transfusion at diagnosis and 55% of all patients received supportive care only.

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PMC11766309

In adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), colon adenocarcinoma (COAD), kidney chromophobe (KICH), kidney clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), ovarian serous c...

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PMC8009078

The normal mode analysis (NAM) and interaction entropy (IE) methods are considered to calculate the entropy.

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PMC9429973

In addition, exquisite sensitivity of NOTCH1-mutant and SF3B1-mutant cell lines, contrary to their wild-type counterparts, was revealed towards the inhibitors of various hormone receptors or inhibitors of 20S proteasome.

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PMC9429973

No SAEs assessed were deemed to be related to lilotomab and Betalutin®, by the investigators.

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PMC10024132

Unlike typical monoclonal antibodies (mAbs), it does not have an Fc domain and therefore is not protected by the neonatal Fc receptor-mediated recycling process from non-specific catabolism.

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PMC11708541

Moreover, it was demonstrated that both dopamine depletion in the striatum and methyl-phenyl-tetrahydropyridine (MPTP) induced neuronal death in the sensory neurons were prevented by 4-AP.

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PMC9429973

Results: 1) We established the in vitro model with locally distributed MET, and the MENK can efficiently eliminate the MM cells.

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PMC11521786

However, the contribution of the cellular response potentially induced by this vaccine to its antitumor effect cannot be ruled out, although it remains to be demonstrated.

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PMC11402217

H&E staining images of OS tissue from each mouse group Scale bars = 1 mm. (

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PMC11736898

We observed a trend toward decreased proliferation with increasing levels of vitamin D (0–100 nM) after 24 h of treatment, although the differences in proliferation were not statistically significant (Figure 1).

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PMC11546117

Breast cancer resistance protein (BCRP/ABCG2) has been described to be one of the main transporters at the blood–milk barrier.

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PMC9884169

Target cells were seeded in six-well plates and cultured in an incubator for 24 hours.

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PMC7868205

SEM and TEM are electron microscopic techniques used to study the morphology of nanomaterials at various magnifications.45,46 The representative images are presented in Figure 3A–D.Figure 2XRD pattern of the synthesized nanoparticles.

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PMC7612475

Therefore, to assess this, we initially determined whether SF3B1 depletion would have a deleterious impact on cell survival following the induction of DNA double-strand breaks (DSB) using two independent siRNAs.

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PMC11547972

An old study conducted in 1982, involving 175 cancer patients, did not report a clinical benefit of amygdalin .

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PMC11597291

The outmost of the effect on G2 phase and cellular apoptosis was observed at 15 h after light onset (HALO).

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PMC11082662

P<0.5; **, P<0.01 ***, P<0.001; ****, P<0.0001; N.S., not significant.

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PMC9429973

The study is open for enrollment.

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PMC10993311

The uterus undergoes intense vascularization due to the need for greater blood perfusion.

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PMC11682172

The passage of MDA-MB-231-B2M2 cells was less than for MDA-MB-231 and SK-BR-7.

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PMC11544122

Serial dilution (1:1) was performed from tubes #2 to #16.

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PMC9429973

Detection of acquired BTK and PLCy2 mutations on therapy is feasible and may herald clinical disease progression.

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PMC7802142

Here, ReN-NV were revealed to have the capacity to promote DPC proliferation.

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PMC4485786

Quantification of I-labeled NHS-IL12 showed 4- to 6-fold radionuclide enrichment in the tumors compared with the contralateral muscle.

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PMC11721295

Mouse and human peptidylprolyl isomerase A and β-actin were used as housekeeping controls.

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PMC9917080

It is known that Ca ions as a second messenger regulate almost all cellular functions, including proliferation.

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PMC11711663

Head and Neck Squamous Cell Carcinoma (HNSCC), which arises from the epithelial layers of the oral cavity, pharynx, and larynx, accounts for 90% of HNC cases.

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PMC11767725

Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like Staphylococcus aureus without disrupting beneficial flora.

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PMC11367146

These results confirmed that VTE effectively inhibited the proliferation and migration of IL-1β induced cells after 24 and 48 h of incubation.

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PMC11546117

The apparent permeability coefficient (Papp) was calculated using Equation (3).

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PMC11387401

Limited dilution and Zeocin selection produced stable monoclonal cell lines that (without doxycycline induction) constitutively express a single 2xStrepTagII-TEV-3xFLAG-tagged MA, NC, or Tat protein.

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PMC11300639

TCGA-KIRC dataset analysis and RT‒qPCR analysis were used to examine the pathways affected by RNF26 silencing.

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PMC11129910

We examined mammary spindle cell carcinomas to corroborate our in vitro findings as they best exemplify the claudin-low, mesenchymal phenotypical breast tumor.

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PMC11748618

Chromatin states of PBMCs from individuals of African (ENCFF863IVL) and European ancestry (ENCFF235OWS), as well as LCLs from individuals of African (ENCFF747OPJ) and European ancestry (ENCFF070KWN), were obtained from ENCODE.

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PMC11683130

Reduced expression of SerpinA12 in keratinocyte has been reported to decreased expression of the desmosomal proteins, cornified envelope proteins, and keratins (55) which are proteins that maintain the integrity of the epidermal barrier.

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PMC11730311

hαCGRP8-37N25K-C20DA-γGlu was identified as the most potent of the tested lipidated hαCGRP8-37 analogues.

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PMC11488203

To estimate the amount of taxol in these MSC-derived EVs/exosomes, extensive LC–MS/MS analyses in a previous work have demonstrated approximately 123 ± 0.7 nM taxol in the EV/exosome preparations .

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PMC11543853

In bafilomycin A1-treated samples, the odds ratio of genome release was reduced approximately two-fold in cytoplasm (OR = 0.47, 95% CI 0.28–0.78, SE = 0.26, z = 2.90, P = 0.0037) and about 15-fold in vesicles (OR = 0.063, 95% CI 0.028–0.144, z = 6.57, P < 0.0001).

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PMC8633974

Cell-directed delivery of CRISPR-Cas9 is an essential element for HIV-1 elimination.

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