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PMC3730428
In particular, we focused on the impact of TNFα on sensitivity to SMCs as we hypothesized that SMCs could convert this pro-inflammatory cytokine that is present in the mesothelioma microenvironment into a potent apoptosis inducing cytokine by downregulating cIAP1 and 2 and, thereby promoting breakdown of the pro-surviv...
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PMC11790599
These abnormal macropinosomes undergo homotypic fusion, generating large vacuoles that are unable to recycle like normal macropinosomes or fuse with lysosomes due to the downregulation of key molecular components required for fusion with recycling endosomes and lysosomes (ARF6 and SEPT6) by TSL.
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PMC9429973
Aims: To evaluate frequency, duration, efficacy and tolerability of iron chelation in patients with CHAs followed at our reference center.
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PMC5261804
For LUAD patients, 15 PPIs were met this criterion (S2 Table, Fig 5B).
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PMC9429973
Two patients achieved complete remission (CR) after 2 courses of induction therapy.
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PMC11218145
This effect could be ascribed to the inhibition of the activity of FPPS, a key enzyme in the mevalonate acid metabolic pathway and major molecular target of nitrogen-BPs .
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PMC6600592
Many compounds showed more effective in inhabiting secretion of HBsAg and HBeAg than that of lamivudine, and among them compound 4B-2 showed inhibition of HBsAg (IC50 = 63.85 μM, SI = 13.41) and HBeAg (IC50 = 49.39 μM, SI = 17.34), with low toxicity (CC50 = 856.2 μM), and compound 4B-3 in inhibiting secretion of HBsAg ...
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PMC10719213
Thus, cladribine could damage the mitochondrial genome by altering nucleotide metabolism.
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PMC9503669
Interaction with Nef, on the other hand, was reversible by SPR and did not result in stable adduct formation by mass spectrometry .
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PMC8903741
To produce H chain of antibody, a signal peptide gene (caccatgggatggagctgtatcatcctcttcttggtagcaacagctacaggtgtacactcc) followed by HC gene of anti-hMMP9 antibody was synthesized and digested with NotI and HindIII.
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PMC8956657
Source data are provided as a Source Data file.
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PMC10890055
The concentration of Zn, ranging between 72 and 102 µmol∙L, is shown for particular alloys on the labels above the columns of the graph.
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PMC11727062
Additionally, it is crucial to establish the safety, efficacy, and precise mechanisms of action of these herbal monomers in clinical setting.
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PMC11527437
Nine patients received two doses of the vaccine (prime and boost), which consisted of DCs exposed to (aka pulsed with) various long and/or short mKRAS peptides.
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PMC11012313
Furthermore, inhibitors of mTOR were less successful in clinical studies in the treatment of B cell lymphomas than expected based on pre-clinical experiments , suggesting the need for multi-target approaches that include inhibitors of mTOR in conjunction with HIF-1α.
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PMC7171147
Furthermore, we discovered that COL11A1 upregulates de novo fatty acid synthesis to derive fatty acids for oxidation in ovarian cancer cells.
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PMC11055443
According to the decrease in the TNF-α, IL-1β, and IL-8 as well as NO production, it appears that the AD-MSCs secretome inhibits the NF-κB signaling pathway (35).
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PMC7039683
Significantly, we found H3K27Ac cluster elements both near genes expressed at high levels in superficial palate epithelium (palate periderm) (e.g., Krt17, Figure 5E) and near those expressed in basal palate epithelium (e.g., Krt14, Figure 5—figure supplement 1D), showing that the isolated epithelium contained both of t...
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PMC11361748
Migration of human primary neutrophils towards CM from A431 keratinocyte cultures.
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PMC11638255
Significance was calculated using a two-tailed Mann–Whitney U test with p values displayed in figure.
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PMC6642070
It has been reported that patients carrying inherited β-enolase deficiency present with a mild myopathy similar to some forms of SAMS .
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PMC7823217
A. The important components within breast cancer microenvironment including interstitial matrix and the basement membrane proteins (left circle).
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PMC11506670
Cells were visualized using the IN Cell Analyzer 6000 (GE Healthcare) high-content imaging system, from multiple randomized perspectives.
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PMC11467800
When we compared the ability of leukaemic cells to migrate out of the bloodstream, we revealed that K562‐IR cells outperformed the others.
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PMC11001582
Primers for mouse C9orf72 are: 5′-TGAGCTTCTACCTCCCACTT-3′ and 5′-CTCTGTGCCTTCCAAGACAAT-3′. Primers to amplify the knock-in sequence are: 5′-GCGGCGAGTGGCTATTG-3′ (primer located within mouse C9orf72 gene at exon boundary 1-2) and 5′-GGGTAAGCGTAATCTGGAACATC-3′ (sequence within the HA-tag sequence).
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PMC11762280
The density of the interested protein band was calculated using ImageJ software and compared with β-actin (ACTB) as relative quantification.
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PMC11546117
MCF-10A cells were expanded according to the protocol from the BRUGGE lab, department of cell biology, Harvard medical school (https://brugge.med.harvard.edu/protocols.
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PMC11753949
In contrast, the two sheet-forming proteins that we investigated, namely GFP-Kinectin (Figure 6E) and GFP-Climp63 (Figure 6F), did not localize to the flat portion of SALs sheets, indicating that they do not play a role in their formation.
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PMC11665584
Interestingly, the only predicted factor originating from keratinocytes was Shh, the prototypical Hedgehog (Hh) signaling pathway ligand.
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PMC9429973
Standard chemotherapy using cytarabine and idarubicin/daunorubicin usually achieves remission, but this is commonly followed by chemoresistance and relapse.
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PMC6901583
Mice were treated with IgG or αCCL2 antibody.
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PMC9429973
Trial treatment was well tolerated.
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PMC11585587
The Bcl-2 protein family regulates apoptosis by controlling mitochondrial permeability.
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PMC11568601
Highly upregulated expression of ERN1 and HSPA5 was detected in the 80 mg·mL TGT group (Fig. 4A).
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PMC8414691
Fig. 3Depletion of SRCAP affects cell division in HeLa cells.
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PMC11782508
Fig. 8Effect of purified azurin on MCF7 breast cancer cells. (
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PMC5386478
Statistical evaluation of the differential analysis was performed by one-way ANOVA and Student's t-test.
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PMC11676169
Foci were counted using ImageJ software.
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PMC11555465
According to demographic forecasts, the annual incidence of new cancer cases globally will exceed 35 million by 2050 (1).
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PMC10936243
Restrictions which impede good management.
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PMC11604830
This accumulation was already visible by T2w MRI, but HCSI provided also quantitative analysis.
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PMC9503541
The m/z and rt values with the most negative values of covariance and correlation significantly contributed to the separation between the active and inactive components.
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PMC11354239
These cytotoxic lymphocytes, with their inherent ability to identify and eliminate stressed cells, including tumor cells and specific infected cells, offer a promising avenue in cancer treatment.
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PMC11753949
Both regions upstream (residues 1–384) or downstream (residues 474–690) retained their ability to localize to stress fibers (Figure 3E–F), confirming that synaptopodin can directly or indirectly interact with F-actin through multiple regions.
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PMC11617590
These results suggest that the inactivation of GSK‐3β by treatment with SFN accumulates the β‐catenin in KRAS mutant cells such as Mia PaCa 2 cells.
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PMC11243198
In the case of C3H10T1/2, they were optimized for high-throughput screening (HTS) using DMEM.
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PMC9429973
One patient with low PC had ruxolitinib interruption due to thrombocytopenia.
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PMC9509578
Han and co-workers showed that inhibition of GST through ethacrynic acid-conjugated polymeric nanoparticles (MPEG-PLA-SS-ECA) could overcome the tumor cell detoxification system and associated drug resistance.
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PMC10723784
In the cell division process, cell cycle arrest can occur as a result of DNA damage or errors which cannot be repaired.
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PMC9119314
Low-resolution mass spectrometry (LRMS) was carried out on a Quattro Ultima Triple Quad Mass Spectrometer (Micromass) in electrospray positive and negative modes.
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PMC11594641
The tetraspanin CD81 was down-regulated in RAB27A KO SkMel28 cells, while the remaining markers were at comparable levels in cell lysates.
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PMC10470467
Here, we first investigated the differences in immune cell infiltration patterns between the high- and low-risk groups.
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PMC9429973
To identify predictors of survival and clinical success, univariate and multivariate analysis was performed.
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PMC11783017
The Mn/NH@PGP group displayed a significant reduction in tumor volume, suggesting the inhibitory effect on tumor growth, which was probably due to the chemodynamic activity of Mn and the NHWD-870-mediated modulation of tumor-associated pathways.
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PMC6642070
At the meantime, we recognized the intricacy of the topic, with many studies showing little impact of statins on muscle symptoms , the lack of appropriate animal models , and studies showing no obvious elevation of lactate levels with statins treatment .
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PMC11772449
Statistical methods: single factor analysis, *P<0.05; **P<0.01; ***P<0.001 In conclusion, PFD is an inhibitor of p38γ, which may affect the Beclin pathway by inhibiting the function of p38γ, thereby inhibiting the level of autophagy, and ultimately achieving the effect of sensitizing Sora.
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PMC10940855
n = 6/group, AVOVA was used for light-chain analysis.
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PMC7334607
Original drug response data from the long-term evolution experiments may be accessed through Mendeley Data: https://doi.org/10.17632/vbc3gjjgyn.1.
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PMC11539788
Conversely, RNF19A knockdown led to increased protein levels of p-AKT, p-mTOR, and p-S6K1 (Fig. 4I-J).
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PMC11047729
Withaferin-A (Wi-A) is a steroidal lactone that can be found in Withania somnifera (Ashwagandha).
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PMC11352746
The remaining articles all used location-specific neurons from rodents for their studies .
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PMC9429973
Variants three, eight, ten and twelve are not previously described and its significance is unknown (Table 1).
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PMC11200978
A single freeze to −20 °C resulted in a significant decrease in 24 h viability to 10.6% (± 0.5) (p < 0.01).
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PMC11739670
CD8 extracellular domains (CD8α—Uniprot P01732, residues 22–182 or CD8β—Uniprot P10966, residues 22–170) were cloned into pFUSE‐hIgG1e3 (Invivogen), downstream of a mouse kappa light‐chain secretion signal and upstream of an engineered human IgG1 Fc (IgG1 constant heavy chain [IGHG1] CH2‐ and CH3‐domains that had been ...
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PMC10849234
The four classic neutrophil granule types are named in order of their appearance during granulopoiesis, with primary granules developed first, and secretory vesicles not appearing until neutrophils are terminally differentiated.
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PMC10854447
The antiproliferative effect of compounds 7a–o against four cancer cell lines was investigated using Erlotinib as the reference drug.
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PMC10421378
After inoculation, the growth parameters were set at 30 °C, with a stirrer speed of 150 RPM and pH set at 6.5 (the optimal value for the selected strains).
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PMC10631132
Cells differentiated according to the EB protocol showed large multinucleated polykaryons (solid arrows in A, E) which also demonstrated Cathepsin K expression (arrow tips in B, F).
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PMC9429973
Results: As of 17 Dec 2021, 58 pts received BGB-11417 (32 monotherapy; 26 combination).
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PMC9596868
PA-1 cells were treated with 1µM MST-312, 10 µM quercetin and their combination for 24 h. Control group was treated with DMSO as a vehicle.
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PMC11585587
Fig. 4The mitochondrial pathway effect of RA on MM cells.
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PMC11638255
Transforming growth factor-beta (TGF-β) levels were determined using an enzyme-linked immunosorbent assay kit (Invitrogen, USA; #BMS608-4) according to the manufacturer’s instructions.
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PMC11738017
Target MM cells were resuspended in fresh media at 1 × 10 cells per mL with or without GSI at time 0 and cultured alone for 48 hours to allow the accumulation of sBCMA in the media.
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PMC11583010
At the indicated time (black arrowhead), three different ADCs were injected intravenously: isotype control (10 mg/kg) conjugated to maleimide–ß-glucuronide–exatecan–PSAR (open diamonds), ETx-22 (from chimeric 15A7.5) at 4 mg/kg (plain blue arrowhead), and EV at 4 mg/kg (plain brown arrowhead).
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PMC9268620
There were no healthy cells found in the treatment using 30 μg/mL of nordamnacanthal.
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PMC9429973
In the AML group PLT recovery (defined as a stable PLT count ≥20×10/L without the need for PLT transfusion) was observed in 18 (81%) patients with a median time to recovery of 22 days from the start of the chemotherapeutic regimen (range 18-41).
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PMC10538569
To specifically test the initial blocking of trans-infection by GPI-scFv X5, we performed single round infections with a panel of iDC- or mDC-captured HIV-luc pseudotyped with different Env proteins.
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PMC11789597
Bortezomib or/and 6‐MP, or daidzin, or simvastatin were administered by intraperitoneal injection at the indicated times.
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PMC11566417
A PMA-stimulated condition was added to determine whether MDEC CM affects stimulated as well as resting neutrophils, as neutrophils may be activated during infections .
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PMC11643361
A structure–activity approach revealed that the dipole moment displayed the most significant direct correlation with the IC50 value, as a decrease in the dipole moment increases the lipophilicity of these compounds, influencing their biological properties, partition, and anticancer activity.
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PMC9429973
Choices of treatment are also influenced by physical and emotional impact of hospitalization or frequent hospital visits, which reflects the patient’s ability to continue their treatment and quality of life.
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PMC8540692
Similar results were obtained after the treatment with Aza—the methylation level of RUNX3 dropped slightly, so the HRM curve reached the level of 75% in A-172 cell line, and was in the range of 25–50% in T98G cells.
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PMC7724160
Samples were analyzed with a Nexera UHPLC (Shimadzu Scientific Instruments, Columbia, MD) column connected to an ion trap mass spectrometer (Exactive Plus) using a heated electrospray ionization source (ThermoFisher Scientific, San Jose, CA).
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PMC7053076
HL-60/5FU cells exhibited a 6-fold enhanced resistance to 5-FU as compared with HL-60 cells.
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PMC11320834
The input data included cell response to the single drug and combination treatment as %viability.
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PMC10203589
However, whether FGFR1 is a direct target of FGF18 in MPM remains to be explored.
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PMC9429973
SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia and progressive organ failure.
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PMC7171147
A stringent 1% false-discovery rate (FDR) was set to filter peptide and protein identifications.
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PMC11626627
Our findings extend the understanding of TWIST1’s role in RCC, complementing functional studies of TWIST1.
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PMC11011837
The bar graph in Figure 7 shows that the most abundant chains are those composed of 16, 18, 20, and 22 carbon atoms.
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PMC10674574
The low-permeability group includes substances with a Papp below 0.74 [×10 cm/s].
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PMC4355729
A growing body of evidence indicates that the PI3K/AKT pathway is involved in the migratory process of cells, including metastatic cancer cells33.
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PMC11348300
In this study, we assume that extracellular oxygen is similar to intracellular oxygen at equilibrium.
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PMC11538390
Here we have shown an association between three independent SNPs and CP in Finland.
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PMC9219615
Only cell populations with ≥95% viability and at 60–75% confluence in the exponential growth phase were seeded into multiwell plates to minimize baseline cell death.
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PMC10297204
Photographs were taken at time points 0, 24, and 48 h at ×10 magnification using a Nikon ECLIPSE Ts2 microscope.
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PMC11297139
Molecules that undergo LLPS typically display condensates and form distinct droplets inside the cell.
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PMC11519583
However, the functional regulation of these tissue stem cells remains largely unclear .
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PMC8978939
Representative Western blot showing immunoprecipitation of GFP-trap for each cell line expressing GFP, VHL-WT, P138R, or L163R.
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PMC11802855
The expression level of CXCL7 in the CXCL7-KD and NC U266(D)/RPMI 8226 (E) cell lines was evaluated via qPCR.
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