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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Six cases (50%) were positive for PTEN mutation and 3 positive for FBXW7 mutation, other mutated genes including NOTCH1, TP53, CCND3, etc.
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PMC11599565
Nevertheless, in other ovarian carcinoma cell types, the kinetics of such markers oscillated.
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PMC9429973
Our results corroborate the idea that targeting lactate metabolism may represent a promising path to counteract inflammation, osteosclerosis and fibrosis in PMF patients.
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PMC9429973
HMX3 silencing in THP1 and MOLM13 cells caused pronounced cell cycle arrest and apoptosis evidenced by PI, Annexin and 7AAD staining in flow cytometry.
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PMC10808409
As shown in Table 3, the EE % and the particle size for the optimized formula were 91.00 ± 0.09% and 19.94 ± 0.07 nm, respectively.
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PMC7602170
The clinical use of the RTK inhibitor imatinib has significantly improved the management of GIST patients; however, imatinib resistance remains a challenge.
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PMC11754784
f Flow cytometry analysis of CEM cells treated with cage-Nb, cage-Nb-sgc4f, cage-Nb-sgc8c, and DNP2 in Cy5 channel, TAMRA channel and FAM channel.
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PMC3995603
However, concerns over systemic toxicity have limited their use .
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PMC11261875
Fig. 1A schematic illustration of the relationship between gastrointestinal stromal tumor (GIST) and glycolysis and oxidative phosphorylation (OXPHS).
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PMC11397654
Additionally, the analogues containing a phenylthiourea moiety (68b, 69b) were prepared to study the effect of the fluorescein unit on the cytotoxicity of the macrocycles.
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PMC9429973
Using the ratio between the observed frequency in cfDNA/BM and that observed in PPCs, we estimated an average tumour burden of 6% in cfDNA and a mean clonality of ~30% in BM.
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PMC9693627
After incubation for 40 min on ice, the insoluble material was removed by centrifugation at 18,000× g for 1 h at 4 °C.
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PMC9429973
However, the dual supporting abilities of BM EPCs to normal HSCs and malignant cells in patients with different stages of MDS remain unclear.
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PMC8316344
As knocking out TFRC and βTrCP plays contrary roles to control labile iron (Fig. 6), and tumor cells often show iron addiction to sustain cell proliferation ; we were curious to know whether TFRC and βTrCP are also essential for cell proliferation in liver cancer cells.
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PMC11122631
Initially, potential conformers were generated using Spartan20 software.
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PMC11244823
Surprisingly, antibodies against gD1_83 were restricted to horses with a history of vaccination against EHV-1.
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PMC9424261
A Immunoblotting analysis of the expression of HERPUD1 in liver cancer cells after Crispr–Cas9-mediated HERPUD1 depletion.
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PMC11389534
Consequently, the regulatory potential of UFMylation in immune responses remains largely undeveloped, awaiting further investigation to uncover its significant contributions to the field.
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PMC9429973
Three dose levels (DL) of InO given on Days 8 and 15 were studied in 28-day cycles: DL1, 0.3 and 0.3 mg/m; DL2, 0.6 and 0.3 mg/m; and DL3, 0.6 and 0.6 mg/m (respectively).
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PMC11394730
Flavonoids are naturally occurring polyphenolic compounds with several demonstrated benefits, such as anti-inflammatory, anti-diabetic, antimicrobial, anticancer, antioxidant, antiviral, and anti-allergic properties .
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PMC9693627
It turned out that steady-state levels of both proteins were reduced, but the decrease in COIII was much more pronounced (Figure 1E).
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PMC11413393
The detailed resources for each compound are listed in Supplementary Table 1 the additional file.
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PMC9429973
Aims: To assess HRQoL in patients with RRMM who received IBER + DEX in cohorts D and I of the CC-220-MM-001 trial.
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PMC11590005
The prejudice was con-servative and demonstrated the effect of ambiguity among Asian university students .
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PMC9429973
Methods: We performed an extensive in vitro characterization of the NK and MSC interactions by co-culture system.
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PMC9596868
of drug/ compound (µM)Combination index (CI) reportedCell lineRef.1Quercetin and Cisplatin7.5100.34Hela (cervical cancer)150.55300.6412.5120.59Siha (cervical cancer)250.72500.75Quercetin and Cisplatin5801.11C13* (ovarian cancer)101.28151.21201.16301.15400.97600.96800.97Quercetin and Cisplatin9.08–145.220.26–4.090.94A27...
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PMC9503685
After washing with PBS, cells were lysed with 0.5% Triton-X solution in DMEM, and the number of intracellular viable bacteria released was determined.
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PMC10873328
The survival probability of prognosis model based on the risk score in training cohort. (
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PMC11413393
In addition, there is a general trend towards accumulation of pre-spliced transcripts in the nucleus that first decreases but then increases over time, as illustrated by increasing pre-spliced to post-spliced ratios in the nuclear fraction on days 5 and 7 (Supplementary Fig. 9d).
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PMC11679326
Because OXYL is able to recognize LacNAc type 2, it can also be positioned to target (poly)LacNAc-containing N-glycans, which appear to be a marker of glioma stem cells.
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PMC4355729
Other cells were maintained in RPMI 1640 medium (Gibco).
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PMC11750696
In systemic lupus erythematosus (SLE), while the disease is often manifested by the production of autoantibodies against nuclear antigens and self-proteins, it is the dysfunction of T cell activity and the imbalance of T cell subsets that significantly contribute to the condition (63).
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PMC11297139
GFP-tagged proteins in cell lysates were enriched using GFP-Trap magnetic bead (Chromotek).
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PMC11286266
On the left, a protein–protein interaction network (Metascape) for the 100 top hits identified in the CRISPR/Cas9 screen for potential repressors of ATF6α signalling is shown. (
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PMC9841531
As MCT1 inhibitors are barely known with only roughly 100 representatives in the literature, no standardized assay procedures have been developed compared to methodologically better-explored protein (super)families, as, for example, ABC transporters.
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PMC11806818
Due to the excellent peroxisase-like activity of the (MnCo)Fe2O4 nanozymes, in the presence of H2O2, the (MnCo)Fe2O4 nanozyme catalyzes the oxidation of 4-chloro-1-naphthol (4-CN) in situ, forming an insoluble precipitate on the photoanode, resulting in sharp attenuation of the PEC signal.
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PMC11588085
Low levels of XIST in ovarian tumors indicate more M-CSCs, which are more invasive, and are more likely to cause tumors to become aggressive and metastatic, leading to a lower survival rate for patients with low XIST expression.
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PMC11306019
Our findings underscored the pivotal role of aromaticity and conjugation properties in the antagonistic effects exhibited by flavonoids.
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PMC11476837
Firstly, we performed experiments that confirmed differences between HL-60 and HL-60/DR cells in response to doxorubicin, including cell viability, apoptosis, and intracellular ROS level (Figure 2).
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PMC11283030
To the best of our knowledge, this is the first study to elucidate the prognostic role of ACLY (including p-ACLY) protein in ccRCC tissues.
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PMC11127909
Mitochondrial energy metabolism in dorsal root ganglion neurons .
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PMC10813895
Horvath’s pan-tissue clock, which estimates biological age using 353 CpG sites across various tissues, has been linked to age-related diseases .
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PMC9545714
This is the glucosylated precursor of the linoleate‐containing acylceramide.
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PMC11307990
These results showed that chitosan shields encapsulated 6HB-DONs from nuclease degradation, indicating that DNA nanotapes were able to maintain structural stability under cell culture.
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PMC11438317
To further demonstrate this point, we mutated to Phe the 6 Tyr, and tested its interaction with LP-DACS.
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PMC6742971
The strength of the interaction between T cells and antigen-bearing cells depends on the TCR affinity to peptide-MHC, and on multiple co-receptors that together determine the overall binding kinetic and consequent signaling into T cells.
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PMC11774747
For example mice treated with HER2.CAR-VST had a significantly longer survival, in a brain tumor model (85).
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PMC10976516
It became evident that systemic application of cell carriers loaded with OVs holds a promise for significantly improved OV therapy against primary lung cancer as shown in numerous (pre)clinical settings (Tables 2 and 3).
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PMC11515150
ELISA data showing the release of IFN-γ by NT-T cells and CD5 CAR-T cells after co-incubation with target cells overnight (n = 3; n.s.,
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PMC9388315
Results were represented as mean ± standard division (SD).
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PMC11650848
Scaled scores were used to correct for any small differences in age.
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PMC9429973
Aims: The aim of the present study was to evaluate a new sensitive approach based on a drop-off dPCR assay for CXCR4 mutation detection in BM and peripheral blood (PB) samples from WM and IgM-MGUS patients, enrolled between 2018 and 2020 in the multicenter observational trial from the fondazione italiana linfomi (“BIO-...
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PMC10142392
These formulations can be activated by external or internal stimuli, such as pH changes, temperature, irradiation, magnetism, concentration gradients, or enzymatic activity.
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PMC11721587
HEK293T cells were cultured in DMEM containing 10% FBS (Thermo Fisher Scientific).
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PMC9429973
Fatal outcome had 17.8% of patients with the cause being the progression of underlying disease in 51% and comorbidities in 49% mostly cerebrovascular stroke (7 pts), heart disease (7 pts) and secondary malignancies (6 pts).nalyzed.
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PMC11502443
cAMP and IP1 accumulation along with phosphorylation of AKT, ERK and CREB are all key molecules involved in signaling events which promote insulin release and influence β-cell/adipocyte cell function and survival (Tengholm and Gylfe, 2017; Straub and Sharp, 1996; MacDonald et al., 2002; Song et al., 2007; Camaya et al....
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PMC11001582
WT (n = 4 mice), (GR)400 (n = 5 mice), (PR)400 (n = 5 mice); one-way ANOVA, Bonferroni’s multiple comparison.
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PMC11371747
Values are means ± SEM from three separate experiments.
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PMC11365983
Statistical analyses: Tukey HSD test post hoc one-way (A–F) or two-way ANOVA (G)].
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PMC11354225
All assays were performed using technical and biological triplicates.
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PMC10729469
Immunohistochemistry visually showed a remarkable increase in the number Iba1 positive (Iba1+) amoeboid cells in cortical and hippocampal tissues of untreated APP/PS1 mice compared to non-transgenic mice suggesting increased microglia activation in AD mice (Fig. 6A).
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PMC9599726
Images were displayed in the linear mode with manual contrast adjustment and exported as 16 bits uncompressed TIF files.
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PMC9919300
One microgram of RNA was retro-transcribed using the RT First Strand kit (Qiagen) according to the manufacturer’s recommendations.
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PMC6627640
Pluripotent ECs represent the stem cells of non-seminomas and differentiate into mature non-seminoma subtypes .
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PMC9429973
An index line of therapy (LoT) will be selected for all pts with more than one recorded LoT. Imbalance adjustment will be performed by re-weighting the TLNext cohort using weights determined from distributions of prognostic clinical factors observed in M SAT.
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PMC9119314
Cryptolepine (1) was isolated using a two-step Soxhlet extraction of C. sanguinolenta roots, followed by crystallization (yield 0.8% calculated as a base with respect to the dried roots).
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PMC6627640
A greater understanding of the hypersensitivity and curability of testicular germ cell tumors (TGCTs) has the potential to inform strategies to sensitize other solid tumors to conventional chemotherapies.
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PMC9429973
At each age of assessment, HJB score was strongly significantly lower in transplanted than in non-transplanted children (p<0.001), (Figure 3) and the score in transplanted children was significantly positively correlated with the age at transplant (r=0.335; p=0.002).
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PMC6160470
This correlates to their affinity for alkali cations (especially K) and better extraction capabilities (Supplementary Tables S1 and S2).Table 1In vitro growth inhibition of A2780 and A2780/Adr cell lines by crown-ethers.
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PMC11747467
After regular RC48 treatment, we found a higher treatment efficacy of drugs in the group of ERBB2 overexpressed group ( Supplementary Figure S8 ; Figure 3G ).
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PMC10197932
All density plots are representative of 3 independent experiments.
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PMC8041314
Molecular formula of the very potent ABCG2 inhibitor 27 (IC50 Pheophorbide A = 0.220 μM; IC50 Hoechst 33342 = 0.260 μM) as discovered in the herein presented virtual screening approach.
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PMC11394386
In CC, while HOTAIR’s role is less established, it has been reported to regulate migration via miR-29b and PI3K/AKT activation .
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PMC6650823
These calculations disclosed the presence of reactive catalytic lysines (pKa < 7.8), suggesting that they may occur in a rarely populated conformational state.
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PMC11794847
Furthermore, HVEM-CAR T showed superior therapeutic efficacy in several mouse tumor models.
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PMC10976516
However, one has to reckon with the most common toxicities of CAR T cell therapy, which consist of release syndrome (CRS) often concurrent with or shortly followed by immune cell-associated neurotoxicity syndrome (ICANS).
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PMC4485648
Mouse monoclonal antibody against CD45 was used as a negative isotype control.
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PMC9429973
None of the patients developed immune effector cell-associated neurotoxicity syndrome (ICANS).
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PMC5673955
Telomerase is highly expressed in more than 85% of human tumors 35.
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PMC9031474
It was observed that the reduction of both aldehyde groups extinguishes cytotoxic activity .
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PMC10729469
After incubation, live/dead stained T cell-MHCII-Aβ tetramer complexes were stained with PE-anti-CD3e, APC-H7-anti-CD4, PE-Cyanine5.5-anti-CD8a, PE-, and Alexa Fluor 488 labeled anti-FOXP3 for flow cytometric analysis.
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PMC11462673
H&E staining and hCD45 flow cytometry analysis of the mouse liver, spleen, and bone marrow demonstrated a notable reduction in tumor cells in the LDB1 knockdown group in comparison to the control group (Fig. 3I and Fig. S3A-D).
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PMC4485786
Stimulating the immune system to attack cancer is a promising approach, even for the control of advanced cancers.
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PMC9429973
Methods: Enrolled patients had received three or more prior lines of anti-myeloma therapy, including a proteasome inhibitor and an immunomodulatory agent, and were required to be refractory to the last line of therapy.
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PMC11462673
E Co-localization of LDB1 with IRF1, ERG, and ETV6 on chromatin were observed.
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PMC10873328
Nevertheless, the detailed mechanism of hypoxia in OC remains unclear.
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PMC9429973
Since CCSS is influenced by the number of alterations, there were patients where OGM data, though clinically important, did not change the CCSS/R-IPSS category.
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PMC11244823
The mean value of the two runs was used to determine the serological state of each serum.
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PMC11545868
Glycosylation usually results in higher solubility than typical flavonoids due to increased structural stability, which in turn can lead to greater absorption .
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PMC11680562
This distinctive characteristic acts as a catalyst to improve their efficacy and adaptability, making them exceptionally well-suited for a broad spectrum of biological applications.
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PMC11267830
e The number of RNA reads for EZH2 post-indisulam treatment was counted.
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PMC11001582
We therefore used the endogenous mouse C9orf72 sense strand promoter.
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PMC9429973
Results: From the integrated analysis of scRNAseq data from 22 AL patient samples, we identified a total of 27 distinct clusters of cells belonging to 10 unique cell types.
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PMC8973725
In addition, hypermethylation was negatively correlated with mRNA expression, suggesting that ZNF677 expression is silenced by aberrant methylation.
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PMC9503541
It grows around 5–10 m tall and has a diameter of around 15–83 cm.
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PMC11472639
However, this heterogeneity in the number of clonal plasma cells herein is consistent with typical SMM populations, with previous research reporting ranges of circulating clonal plasma cells in SMM of 0.003–20,958 cells/μL (n = 109) (Termini et al., 2022) and 0.005–12.9 cells/μL (n = 25) (Sanoja-Flores et al., 2018).
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PMC6771295
Depending on the type of cancer SIRT5 has been reported to act as both oncogene (17) and tumor suppressor (18).
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PMC11406030
For the construction of Kaplan-Meier plots, the median value served as the cutoff point.
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PMC4695073
The potential mechanisms of platinum resistance include reduced intracellular accumulation and increased detoxification of cisplatin , increased capacity of DNA damage repair , inactivation of the apoptotic pathways and other epigenetic alterations at molecular and cellular levels .
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PMC11470381
A. Front/back (F/B) polarity of Piezo1 and actin of a single cell.
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