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PMC11656048
Collectively, our findings indicated that shikonin induced OS cells ferroptosis through Nrf2/xCT/GPX4 regulatory axis, which might shed light on exploiting shikonin as a promising candidate for the future OS therapy.
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PMC11746942
The quantification of S1PR3 protein levels is shown below each blot.
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PMC9429973
At a median follow-up of 25.1 months, D-Vd prolonged PFS versus Vd alone (median: 14.8 vs 6.3 months; hazard ratio [HR], 0.35; 95% confidence interval [CI], 0.24-0.51; P <0.00001).
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PMC10761571
Therefore, triggering the extrinsic apoptosis leads to the initiation of the intrinsic pathway as well .
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PMC9545714
Also, the subject's hair was off their face, jewelry removed, and a black drape used to standardize clothing.
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PMC3164356
WT, wild type; Mut, mutant; Bov, bovine. (
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PMC10093184
After 21 days of cultivation, distinct colonies of different sizes and cell densities were formed by COS3600B, COS4288, and D-17 cells (Figure 2) .
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PMC9429973
It is imperative that heparin be avoided in these patients.
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PMC11453018
Upon broadening our panel of senescence-related markers, we noted a considerable decrease in LMNB1 expression in all ES cell lines or xenograft tumors treated with iP300w (Figs. 2I and 5B).
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PMC11319300
First, we confirmed that the active enhancer chromatin state that was observed in B cells (Mikulasova et al., 2022) using BLUEPRINT data (Carrillo-de-Santa-Pau et al., 2017) could be validated with other datasets.
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PMC11742231
Extensive experiments and case studies validate its effectiveness in discovering novel miRNA-disease associations.
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PMC11644761
Growing evidence supports the involvement of aberrant DNA methylation in the disruption of key processes such as the development, proliferation, differentiation, and maintenance of oligodendrocyte cells, which are often impaired in neurodegenerative diseases .
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PMC11746942
To identify the specific G protein subtype involved in S1PR3-mediated STAT3 activation, we used inhibitors for Gαi/PKA (H89), Gαq/PLC (U73122), and Gα12/13/RhoA (Rhosin hydrochloride) (Fig. 6D).
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PMC8557138
These tumor PDOs when cultured adjacent to the vascular network showed profound angiogenic response for as long as 22 days.
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PMC11300639
g–i 786-O cells were transfected with the indicated plasmids or siRNAs for 48 h, or treated with Palbociclib (5 μM) for 24 h. Cells were treated with CHX, and cells were collected for western blotting analysis at different time points.
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PMC6024716
The results show that the OAZ1 gene was functionally knocked out in both the 775–1 and 775–3 cell lines.
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PMC6024716
This observation is different from the initial results obtained from the siRNA silencing of the OAZ1 gene, in which there was no increase in luciferase mRNA .
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PMC9429973
The most common grade 3+ AEs and those of special interest were neutropenia (KRd 47%; R 59%), thrombocytopenia (KRd 13%; R 7%), infections (KRd 15%; R 6%), cardiovascular toxicities (KRd 4%, R 5%), and secondary malignancies (KRd 2, R 2).
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PMC5035325
The approach was the combination of the tumor-cell oncosis and antibody dependent cell-mediated cytotoxicity by 14F7 mAb with the inhibition of proliferation, pro-apoptosis effect and the involvement of T cells in the antitumor activity of 7A7 mAb .
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PMC11723947
Naive CD4 T cells isolated from these mice exhibited almost complete deletion of HP1γ, with no compensation by overexpression of the two other HP1 isoforms, the methyltransferases targeting H3K9 or the transcriptional co-repressor TRIM28 (Figure.
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PMC7185206
Cell survival was measured by trypan blue staining.
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PMC9429973
Total cellular RNA was isolated from peripheral blood granulocytes of 141 primary and secondary MF patients and 28 HDs, and we performed Gene expression profiling (GEPs) by microarray platform.
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PMC10033453
A p value of <0.05 was considered statistically significant.
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PMC11064533
We have taken advantage of the unique ability of this strain and characterized it using omics technologies.
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PMC11394386
Finally, PTEN promoter (Supplementary Table S1) was amplified by RT-PCR by standard conditions and then analyzed by electrophoresis on 1.5% agarose gel.
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PMC11335267
Since the effect of D-Trp8-γMSH on food intake is transient and does not last for more than a few hours , and the data in Fig. 8E represent cumulative food intake from the time of agonist administration, the differences observed at 12 h reflect the constitutive decrease in food intake of Alx3-deficient mice as compared...
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PMC6617630
Val cells (THL) showed robust MYC mRNA suppression by I-BET, JQ1, and OTX as compared to that observed in LY1 (DHL) (Fig. 4a, b).
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PMC11615101
The level of α-Taxilin was measured in RA (n = 106), OA (n = 96), HC (n = 30), and SLE (n = 8) patients using an enzyme-linked immunosorbent assay (ELISA) kit (Elabscience, USA), and the level of ACPA in plasma samples in patients with RA (n = 18) was measured using the ACPA ELISA kit (Fine test, USA).
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PMC9429973
Sensitivity to chemoresistance was measured by flow cytometry.
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PMC4355729
In summary, our study suggests that PIK3R1 is down-regulated in RCC, especially in advanced and metastatic RCC.
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PMC8633974
GFP LNP treatment to the cells showed readily detectable GFP expression in both U1 and JLat cell lines affirmed by the shift of population intensities for GFP recorded cells. (
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PMC11531735
Furthermore, we conducted an in vivo assay employing JIMT-1 cells, which originated from a pleural metastasis in a breast cancer patient clinically resistant to trastuzumab.
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PMC11607764
PTBP1 was overexpressed in renal cell carcinoma clinical tissues and significantly associated with tumor size, pathological metastasis status and 5-year overall and disease-specific survival.
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PMC7192625
Capture Hi-C is a variation of the Hi-C protocol that enables studying interactions involving a set of specific non-abundant regions of the genome, for example gene promoters (8).
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PMC9429973
At diagnosis: median PLAT = 26 G/L [0 to 134 G/L], 31% of p. with bleedings.
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PMC8777939
Conditioned media were collected and mixed with acetone at a 1:4 ratio and then stored at −80 ℃ for 1 h. The mixture was centrifuged at 12,000 rpm for 30 min, and the supernatant was removed and eluted with Pierce IP buffer (Thermo Fisher Scientific).
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PMC11544122
Data were analyzed by one-way ANOVA, followed by Dunnett’s multiple comparison test compared to Con.
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PMC11474209
Disadvantage - The operating procedure is intricate; the expense is considerable.
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PMC11741906
In contrast, survival data for hsa-miR-15b and hsa-miR-625 showed that high expression of these two miRNAs correlates with better overall survival of ovarian cancer patients (Fig. 7).
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PMC7185206
Tumor-derived sPD-L1 induces activated human CD8 + T cell death and competes with PD-(l)1 inhibitors for effect on CD8 + T cells.
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PMC9065483
However, upon addition of gefitinib, the concentration of nuclear phosphorylated STAT1 decreased markedly.
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PMC9621239
A total of 1 × 10 Huh 7 cells stably transfected with Lv-Vector, Lv-HBx-WT, Lv-HBx-SM, Lv-HBx-DM or Lv-TM in 100 μl phosphate buffer solution was independently injected subcutaneously into the right-back of eight nude mice. (
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PMC10759659
The plausibility of ARID1A as a biomarker was confirmed by Jiang et al. through pan-cancer analysis using an online database .
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PMC10728200
D–F Western blot analysis of the protein levels of Ki-67, KIT, STUB1, GPX4, and 4-HNE in GIST cell xenograft tumor tissues of mice from vehicle (DMSO), IM, RSL3, and combination treatment groups.
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PMC11802929
In Fig. 2c (left) we provide a sequence logo representation of the 9-mer SCTs that were or were not expressed, and those expressed as SCTs that did or did not capture cells (Fig. 2c right).
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PMC5311252
The overlap between the analyses was also not complete as illustrated by E2F1, which was not identified by mass spectrometry.
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PMC10154881
Each oncolytic virus has its own cell tropism that is dependent on its receptor and the characteristics of virus and cancer cells.
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PMC11786767
Regular immunostaining was performed as described previously (50).
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PMC9429973
6 patients with Ph-positive ALL (75.0%) continued therapy with tyrosine kinase inhibitors (TKI).
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PMC11306331
NIH3T3 and HEK293T cells were obtained from the Lim lab (UCSF) and validated by STR profiling (ATCC).
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PMC11683130
IL-23 plays an significant role in the survival and proliferation of Th17 and Th22, and the Th17 pathway mediated by IL-23 is considered to be the main pathway in psoriasis (13).
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PMC11790971
For each passage, cells were placed in a 96-well plate for imaging (Fig. S3).
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PMC11718109
These vesicles were enriched in neurite varicosities but were much sparser than the other two populations described above.
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PMC11740207
Despite these challenges, recent advancements in sequencing technologies offer promising avenues to overcome the limitations associated with VSELSC isolation and analysis.
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PMC3730428
AT-IAP also induces apoptosis in the breast cancer cell lines EVSA-T and MDA-MB-231, which are sensitive to cIAP1 inhibition (Supplementary Figure 1B).
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PMC9822769
As already reported in the Introduction, molecules with reasonable lipophilicity are generally prone to cross the lipid bilayer membrane by simple energy-independent passive diffusion.
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PMC11720107
In the CACO-2 cell line, extracts from all studied cultivars (Harnaś, Ornak, Violeta, and Morado) similarly decreased both PPARγ and LC3A mRNA and protein expression.
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PMC9429973
Also, COVID-19 infections after vaccine availability were more frequent in unvaccinated pts (37.4 vs. 6.3%, p<0.001).
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PMC7887261
Future extremely large-scale multi-ancestry studies may also provide additional opportunities to assess ancestry-specific predisposing variants, and discover new genetic alterations with relatively large attributable risk for LC.
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PMC9429973
2-yr RFS was also superior in the LIT with VEN group (62%) as compared with the IC or LIT without VEN groups (54% and 42%, respectively).
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PMC11473843
FAK inhibition in genetically engineered KRAS-driven mouse cancer models led to the regression of lung adenocarcinomas (Konstantinidou et al, 2013).
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PMC11737091
Compared with that in adjacent tissues, DBF4 expression was upregulated in most ccRCC tumor tissues (Fig. 2A, B).
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PMC11754784
The samples were incubated at 37 °C for 3 h. After incubation, the samples were transferred into 1.5 ml tubes and centrifuged for 10 min at 5000 rpm.
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PMC10745221
The leftmost panel shows a Coomassie-stained SDS-PAGE gel.
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PMC10142392
Previous research on this copolymer has demonstrated its ability to generate vesicles, with a controlled drug release up to two weeks .
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PMC11394227
Then, 50 μL of the cleavage supernatant to be measured was added to 40 μL of detection buffer, and 10 μL of Ac-DEVD-ρNA at a concentration of 2 mM was added.
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PMC10055960
In addition, the cell culture media without cells were used as a blank, and wells filled with cell culture media and the serial dilutions of each compound were used as color control; three independent measurements were performed.
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PMC11590005
The campaigns were promoted in social media on relevant national and international dates for the struggle against racial discrimination.
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PMC10178190
HGF is a paracrine growth factor secreted by mesenchymal cells, and it targets primarily epithelial cells , and it exerts its function via its receptor, HGFR or c-MET .
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PMC11588008
After being treated with PD98059, the protein levels of p-ERK and HO-1 in PM + MSC groups tend to decrease (P < 0.05) (Figure 8).
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PMC6182045
While the VRC01 antibody does not directly contact a glycan, improved binding may be partially explained by better accessibility of protein epitopes in the context of smaller glycoforms.
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PMC9429973
In univariate analysis, presence of ASXL1 mutation was associated with favorable response (CR/CRi 83% vs 53%, p=0.01), secondary AML (CR/CRi 49% vs 65%, p=0.09), adverse karyotype (49% vs 67%, p=0.11), presence of TP53 (32% vs 67%, p=0.002) and FLT3-ITD mutations (30% vs 61%; p=0.06) predicted inferior response.
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PMC11525293
ACE2 is a p63 transcriptional target.
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PMC4443654
The scale of TAD organization (median length 880 kb) is below that of the multi-megabase chromatin domains delineating occupancy of A and B nuclear compartments .
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PMC11791264
I, SETD7 OE promoted the proliferation of SKOV3 cells determined by cell counting assay.
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PMC10523483
H1.2 levels in indicated NSCLC cell lines and human lung fibroblast cell line MRC5. (
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PMC11746948
Statistical analyses: two-way ANOVA with Tukey’s multiple comparisons test for (c, e–g, i); one-way ANOVA with Tukey’s multiple comparisons test for (a, b, k, l, n).
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PMC11240052
Promotion of apoptosis in overexpressed Circ-0008285 ovarian cancer cells To evaluate the role of hsa_circ_0008285 in ovarian cancer cell behavior, SKOV3 and A2780 cell lines were transfected with siRNA targeting circ-0008285.
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PMC11541241
In conclusion, it appears that the FKBP12‐TOR pathway is conserved in all the investigated fungi.
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PMC9454178
Among the genes screened out by ChIP-seq of GIST tumour samples and cell lines, OSR1 was hypothesized to bind to the c-KIT locus by ATAC sequencing .
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PMC9429973
Seventeen CXCR4 variants were identified (several outside the C-terminus of CXCR4) that caused in vitro functional defects resembling those exhibited by known WHIM variants.
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PMC9920575
It has also been reported that cucurbitacins show anticancer activity , via induction of cytochrome-c release, activation of caspase-3 and caspase-9, and apoptosis through the intrinsic pathway , and there are no reports that show that they activate the death receptor of the extrinsic pathway.
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PMC11055510
This unexpected function of IL1RAP confers on Ewing sarcoma cells the ability to maintain and replenish cysteine and GSH pools, even in the presence of limited extracellular cystine uptake, IL1RAP is used as a cytoprotective mechanism during the metastatic cascade.
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PMC11541409
However, it provides preliminary result of targeting the hypermethylation process in SDH-deficient GIST.
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PMC11476666
For treatment, medium was supplemented with different concentration of stilbenes as described.
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PMC8358006
To understand the function of the putative GSD target genes, we analyzed the biological processes and pathways of the genes targeted by GSDs.
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PMC11629192
Pediatric patients (under 18 years old) who were diagnosed with anti-NMDAR encephalitis according to the criteria proposed by Graus et al. and were treated with OFA as a second-line immunotherapy in the Neurology Department of Guangzhou Women and Children's Medical Center, Guangzhou Medical University, were included.
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PMC9429973
Patients were unvaccinated between March 2020 and May 2021, and partially or completely vaccinated between May 2021 and January 2022.
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PMC11627133
In contrast, small organic fluorophores have been employed for protein visualization through the use of the genetically encodable HaloTag and SNAP‐tag.[ , ]
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PMC10588957
For example, DATS affects tumour development by regulating cell apoptosis (17).
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PMC5535901
The results showed that I3C and DIM pretreatment, at higher concentrations of 50 and 10 μM, respectively, significantly increased PMA/ionomycin-induced interleukin-2 (IL-2), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) production, measured by real time polymerase chain reaction (RT-PCR) and enzyme linked im...
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PMC11755519
In summary, the transfer of substances produced by tumor cells via EVs to the environment influences many stages of tumor progression such as activation of proliferative and angiogenic pathways or modulation of the immune response.
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PMC10728200
The synergistic effect of the combination treatment was measured using CompuSyn software (Paramus, NJ, USA).
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PMC11767817
From an oncological perspective, curcumin offers several therapeutic benefits, and its anticancer potential can be considered from different perspectives.
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PMC10994876
After 24, 48, and 72 h of transfection, a colorimetric cell viability assay was performed using the MTS proliferation assay kit (Promega, USA).
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PMC11764090
Phytohormones are signal molecules that comprehensively respond to plant abiotic stress, and their signal transduction mechanism is related to the plant’s response to cold stress.
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PMC11681005
Loci were K‐means clustered according to their epigenetic modification profiles into 10 clusters.
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PMC9454852
In fact, there is no efficient therapeutic treatment for malignant pleural mesothelioma (MPM).
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PMC10213199
Key upregulated genes in the low-conc.
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PMC10565698
Circular RNAs (circRNAs) contribute to the pathogenesis of different cancers, but their role in LC is not entirely understood.
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