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PMC11724582
Additionally, the mechanism underlying CAF-induced drug resistance in NSCLC cells was potentially linked to the activation of the YAP/TAZ signaling pathway.
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PMC11012012
It is known that SLAMF2/CD48, when expressed by B cells, stimulates cytotoxic activity of NK cells and CD8+ T cells through an interaction with SLAMF4/CD244 .
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PMC10713411
Unfortunately, RCC is associated with poor outcomes, and its incidence has been steadily increasing .
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PMC8633974
Primer sequences for all reactions are provided in Table S2.
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PMC11001582
Having identified functional deficits in the brain, we next assessed motor function in our DPR knock-in mice.
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PMC8992508
Quinazoline and quinoline derivatives In 2016, Krapf et al. investigated several meta and para substituted 4-anilinoquinazolines for their inhibitory activity on BCRP using the Hoechst 33342 accumulation assay on the BCRP overexpressing MDCK II BCRP cell line [Figure 10].
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PMC11476837
HL-60 cells were cultured in flasks at 37 °C in 5% CO2 and sub-cultured every 2–3 days to maintain exponential growth.
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PMC9895440
No effect of SNX9 KO was observed on CD25 expression in unstimulated Teff (Supplementary Fig. 6b).
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PMC11506827
Notably, the distribution of apoptotic cell populations differed between the two cell lines: 786-O cells exhibited a higher proportion of early apoptotic cells and a lower proportion of late apoptotic cells than A498 cells, respectively.
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PMC10747160
Pseudoviruses with additional structural proteins were exclusively produced in 100 mm Petri dishes.
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PMC11725127
We measured the inhibitory effect of GA on cathepsin B and cathepsin D compared with those of their inhibitors, E64D, and pepstatin.
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PMC4443654
and area under the receiver operating characteristic curve (AUROC). (
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PMC11423992
Redirected T-cell cytotoxicity was assessed by detecting dead cells using 7-amino-actinomycin D (7-AAD) (cat. #
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PMC11495567
Similarly, after a 72-h exposure of cells to 0.1, 0.25, and 0.5 μM of NSL-YHJ-2-46 (Fig 7B), cellular migration decreased significantly by 43 ± 1.2, 61 ± 1.5 and 82 ± 2.4%, respectively.
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PMC11747885
Previous research has demonstrated that Rlig1-deficient cells exhibit increased sensitivity to ROS.
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PMC10761218
HepG2 and L929 cells were grown in Dulbecco's modified Eagle's medium (DMEM) (Himedia) containing streptomycin (100 μg/mL) and penicillin (100 μg/mL), supplemented with 10% (v/v) FBS.
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PMC11615101
The arthritic score was calculated based on the macroscopic observations of swelling, edema, and redness in all four paws of each rat.
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PMC11718109
Regions of interest were relocated based on the pre-recorded coordinates, sectioned and imaged.
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PMC11604830
The use of a relatively short TR (TR = 1 s) in the sequence was a relevant prerequisite for reducing the duration of the overall acquisition (17 min for the experiments reported in Figure 2).
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PMC11705862
All western blots show a representative of at least three independent repeats.
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PMC11696659
To do so, we prospectively identified high risk patients that were in the process of lung cancer diagnosis and analysed their telomeres by TAT.
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PMC7351993
The TM node consists of an ADC board (AD9259-50EBZ, Analog Devices) and an FPGA board (KC705, Xilinx) equipped with a 1-Gbps Ethernet port.
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PMC10957991
Specific antibody was utilized to visualize E-cadherin (red) at the cell–cell junctions.
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PMC9812014
The viral CPE of poliovirus on VERO cells was strongly suppressed at doses of 2.5 µg/mL .
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PMC11665584
In the skin, PITX1 expression drove the expansion of Anagen HF and Sebaceous keratinocytes while reducing the proportions of HF Stem Cell, Upper HF Basal, and IFE Suprabasal populations (Supplemental Figure 4B).
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PMC11572213
Metabolic rewiring is a characteristic of cancer cells.
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PMC11638255
We noted copper concentration was marginally decreased in media isolated from untreated neuroblastoma cells relative to control media which indicates tumor cells sequester available copper to support their proliferation (Fig. 6g, gray bars).
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PMC11774747
Advanced trials, like ALLO-501A, report a 67% ORR without GvHD (ALPHA2 (NCT04416984), EXPAND (NCT05714345)) (46).
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PMC11471157
1 Preparation of dried fish powder (DFP) using Medaka (A) Macroscopic image of Medaka. (
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PMC9429973
Along with chronic hemolysis and vaso-occlusion that often accompanies SCD, low Hb levels may contribute to downstream end-organ damage (EOD).
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PMC11766174
Cell pellets from either cell lines or PBMCs were washed once with PBS and fixed with 4% paraformaldehyde (PFA) for 2 h at room temperature.
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PMC11243198
Z27610715 exhibited a moderate reduction in T98G cell viability (a 19.2% reduction at 50 μM).
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PMC11697189
Survival analysis in subgroups found that patients in the high-risk score group had a worse prognosis than those in the low-risk score group, except that there was no obvious difference in the M1 group (Fig. 4C and Supplementary Fig. S4E-4 J).
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PMC6643347
R5 viruses usually exhibit no cytopathic effect, but some isolates – particularly those detected at late stages of the disease – propagate in macrophages to high titers and may induce cytopathic effects .
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PMC11049294
Afterwards, in silico off-target analysis was performed.
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PMC7504302
Given these promising findings, further evaluation of combinatorial inhibition of MET signaling and DRP1 activity in MPM is warranted .
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PMC11033180
Representative images of enteric neurons labeled with FM1-43 at t0s and t4 min after 90 mM KCl stimulation. (
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PMC11599565
It is known that mesodermal-derived cells originate outside of the nervous system, migrate into the hypothalamus where they transdifferentiate into LHRH-producing neurons.
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PMC11335267
Increased expression of Alx3 induced by glucose promotes interactions with the transcription factor PAX6, thus preventing its binding to the glucagon gene promoter and resulting in downregulation of glucagon gene expression .
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PMC10823017
We investigated the dual inhibition of PI3K and PKC-ι with BYL and ICA-1 to determine its effectiveness against cell viability, apoptosis, invasion, and the migration of RCC by indirectly targeting c-Myc.
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PMC6799808
This was evidenced by observations that GLPT increased the phosphorylation of AMPKα (T172) and its substrates tuberous sclerosis complex 2 (TSC2, S1387) and regulatory-associated protein of mTOR (raptor, S792).
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PMC10745221
Therefore, these results strengthen our conclusion from the immunostaining experiments shown in Figs 2–4 that protein arginine methylation is unlikely to play a major role in the reversion of the 143B cells following methionine restriction with recombinant methioninase.
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PMC11615218
Importantly, recent developments in multi-omics profiling techniques, including genomics, transcriptomics, proteomics and beyond, have greatly facilitated the exploration of the remarkable diversity of T-cell phenotypes and expanded our collective knowledge in CAR-T cell therapy.
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PMC11629143
However, the dCas9‐TET1 did not restore mRNA levels to those observed at the start of culture, even though the elevated DNA methylation was fully reversed.
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PMC9250505
It has been reported that dephosphorylated BAD sequesters BCL-XL, BCL-2, and BCL-W, which results in BAK/BAX activation and apoptosis.
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PMC11366496
The data were reported as the Mean ± SD, derived from three autonomous experiments. *
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PMC10243817
Finally, DAPI was used to counterstain the nuclei.
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PMC8540611
For HeLa cells, no significant effects were observed.
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PMC7987994
Three replicates 1–3 were used.
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PMC11607638
Stimulation with SK2 at 30 nM had no effect on CHO‐K1 cells (Figure 5B).
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PMC9693627
We tried to detect any interactions of recombinant PTCD2 with mRNAs (COII, COIII, COI, CytB, and ND5) by several EMSA approaches, but in our experimental conditions such interactions were not found (Probably, PTCD2–mRNA interaction requires some additional factors, e.g., mitochondrial ribosome, CIV assembly factors, or other proteins.
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PMC11753435
The control plasmid is the vector expressing UltraID but not any IP. (
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PMC10788478
LGR5 is a well‐known Wnt target gene and is involved in the progression of several human cancers , , ; however, the oncogenic role of LGR6 and its relationship with the Wnt/β‐catenin pathway in lung cancer remains unclear.
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PMC10965315
The individual data points and significant p‐values are shown in each column, and the data are represented as mean ± SD.
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PMC11711063
Breast cells were treated on 96‐well optical plates at low density and fixed using 4% formaldehyde after 4 days.
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PMC6133382
The flasks were placed into 37 °C incubators with no agitation for 40 minutes.
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PMC11448304
Non-small cell lung cancer (NSCLC) is among the most prevalent malignant tumors worldwide , with lung adenocarcinoma being the most common histological subtype .
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PMC11352311
The advent of immune checkpoint inhibitors and receptor tyrosine kinase inhibitors has significantly improved the survival rate of patients with advanced RCC .
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PMC9220170
Previously, it was repeatedly shown that SELENOT is involved in the regulation of the ERAD system through physical interaction with the components of the OST complex, as well as participation in the processes of N-glycosylation of proteins with disulfide bridges, for example, glycoprotein hormones with disulfide bonds .
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PMC11474209
Understanding these mechanisms is crucial for developing strategies to mitigate MC-LR's toxic effects and protect cellular health.
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PMC3675084
We also monitored the MPM-2 protein, an established marker of mitotic cells that recognizes a group of phosphorylated forms of proteins that are phosphorylated only in mitosis , .
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PMC11731161
The data are expressed as mean ± SD. *
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PMC11687167
Moreover, different STAT molecules, such as STAT1, STAT3, and STAT4, are required for both CD8 + cytotoxic T cell developmental processes and transcriptional regulation .
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PMC11718031
For all experiments under evaluation, the final media consisted of a 0.5% anti-clumping agent and 25 µM Methionine sulfoximine (MSX).
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PMC11747949
The CCL2‐CCR2 axis is indispensable for cancer progression, as it is active in tumor hypoxia, neoangiogenesis, recruitment of immunosuppressing cells, and metastasis (Xu et al. 2021; Yoshimura 2018).
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PMC9429973
Thus, new therapies are needed to improve the prognosis of patients, and combined targeting of MYC and BCL2 appears to be a promising strategy.
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PMC11496728
Gao et al. inhibited Apaf1 in an animal model of neonatal hypoxic–ischemic brain injury by overexpressing the Apaf1-specific inhibitory protein, resulting in attenuated brain tissue loss.
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PMC11537649
RIP assay was performed to validate the direct binding of miR-152-3p and Lnc NEAT1 on Ago2. (
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PMC9429973
Primary involvement of the skin and the bone marrow was present in 28 (59.6%) and 15 (34.9%) cases, respectively.
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PMC11790599
Tanshinlactone selectively inhibits the growth of ER+ and HER2+/EGFR + breast cancer cells while showing limited cytotoxicity against other cancer types and normal cells.
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PMC11001582
n = 8 independent biological replicates, unpaired two-sample Student’s t-test.
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PMC9844987
Predicted transcription factor binding sites for 746 TFs with scores of 500 or greater (P<10) (hg38) were obtained from JASPAR (release 2020, hg38) (Fornes et al., 2020) and for each TF, presence/absence was obtained by overlapping predicted TF binding sites with promoters considered in the modeling.
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PMC11785489
We used TCR position numbers from IMGT to describe the location of each TCR amino acid.
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PMC11700340
Increased Hsp90 expression in initial breast cancer has shown a notable association with poorer survival .
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PMC10470467
The train cohort (GSE17679 dataset) and validation cohort (GSE63157 dataset) were obtained from the Gene Expression Omnibus (GEO, www.ncbi.nlm.nih.gov/geo/).
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PMC9429973
To confirm the presence of exosomes, electron microscopy images were obtained and to quantify their concentration nanoscale tracking analysis was applied (Malvern).
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PMC11792090
IHC staining for CD45 in tumor tissues revealed that SAP UCAR-T cells exhibited a stronger infiltration ability into the tumor environment ( Figures 6E, F ).
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PMC11727306
It is known that the abrin B chain is a lectin with specific binding affinity to the galactose residues on the cell surface membrane and mediates entry of the A:B holotoxin complex into the cell cytosol in a galactose-specific process .
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PMC10391797
CAR, chimeric antigen receptor; HDACi, histone deacetylases inhibitor.
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PMC11224020
Yet, the physical constraints imposed by the environment are likely to vary in distinct tissues or pathological contexts, such as the tumor environment.
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PMC9100622
Peaks were called with MACS2 2.1.1 with the narrow option for EGR2 ChIP-seq and the broad option for histone marks.
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PMC9429973
In contrast to western studies, thrombosis was observed to be higher in CALR mutated group than others in our patient population.
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PMC11782508
The obtained sequence was then analyzed for similarity using the National Center for Biotechnology Information (NCBI) BLAST database (https://blast.ncbi.nlm.nih.gov/).
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PMC11543885
Using enough beads to capture the biotinylated proteins without excess can help minimize the background and reduce the cost of the experiment.
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PMC11462673
Fig. 5Cooperation between LDB1 and master transcription factors to regulate genes transcription.
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PMC8316344
C Deletion of TRIB2 elevated labile iron via TFRC in Bel-7404 cells.
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PMC6650823
In particular, this disease preponderates in women versus men.
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PMC10174970
Second, some cancer cell lines have been derived from primary lesions and others derived from metastatic lesions; how this difference will affect the results of the specific research is unknown.
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PMC9429973
We also demonstrated that ABT-737, a specific Bcl-xL inhibitor, has a synergistic effect in combination with Ruxolitinib in HEL cell lines and MPN patients’ cells, suggesting that Bcl-xL inhibition could increase the power of treatment (Petiti et al. J Cell Mol Med.
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PMC10957991
Ctrl cells were treated with scrambled siRNA and TRPV4 was depleted with specific siRNA against TRPV4 every fourth days.
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PMC10055960
The ligands (1, 2) and bimetallic dirhodium(II,II) complexes (3–6) used in this study (Figure 1), were synthesized following previously published methods .
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PMC11694625
The collected blood was left at room temperature for 40 min, then centrifuged at 3000 rpm for 10 min to collect the serum for detection.
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PMC11588085
There are several biological subtypes of ovarian cancer cells, with High-Grade Serous Carcinoma (HGSC) being the most prevalent subtype, accounting for approximately 70% of ovarian cancer cases.
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PMC11534035
Through treatment with an agonist (G1) and antagonist (G36) of G-coupled estrogen receptor 1 (GPER1), an upstream regulator of SERPINE1 expression, and a forward transfection knockdown protocol, the expression of SERPINE1/PAI1 in VC cells was altered.
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PMC11066331
Unsupervised hierarchical cluster analysis using Euclidean distance matrix with Ward's method further confirms results obtained by PCA (Fig. 6C).
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PMC9429973
The cEPCs population was determined by Flow cytometry based on CD34, CD45, CD133, VEGFR2 expression.
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PMC11678368
These bonds are slightly tilted with respect to the plane, as shown in Figure 1e,f. The calculated Cl–M–N7–C6 torsional angle ranges from 46.6° (for trans-[PdCl2(5ClL)2], Figure 1a) to 49.1° (for trans-[PtCl2(5ClL)2], Figure 1c).
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PMC9429973
PDCD1 (PD-1), CTLA4, LAG3, HAVCR2 (TIM3), TIGIT expression were significantly upregulated in exhaustion T cells of RS patients, suggesting potential treatment target of RS for immune checkpoint inhibitors (Fig. F).
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PMC9429973
All patients who received at least 1 cycle of Pan-Bor-Dex at each site between 01 Jan 2016 and 01 Jan 2018 were enrolled in the study.
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PMC11726848
To ensure adequate protection of the control cells from irradiation, the control cells were seeded to the farthest wells of the plate from the wells containing the cells that were to be irradiated.
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