PMCID
string | Sentences
string | ner
list |
|---|---|---|
PMC6450504
|
siRNA targeting MDR1 (siMDR1): 5′- GGAAAAGAAACCAACUGUCdTdT-3′ (sense) and siRNA nontargeting (siSCR) duplex: 5′-AGUACUGCUUACGAUACGGdTdT-3′ (sense) were purchased from Dharmacon (CO, USA).
|
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PMC10999934
|
Gene set enrichment analysis (GSEA) was conducted with GSEA software, utilizing hallmark pathways gene sets obtained from the Molecular Signatures Database (http://www.gsea-msigdb.org/gsea/msigdb/index.jsp).
|
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PMC11547917
|
Caco-2 cells were cultivated (1 × 10 cells/well) in six-well plates, where compounds were tested in two groups: -Group 1: cells were exposed to Trolox (2 mM) and ethanolic extract (AcE) (150 µM) for 24 h;-Group 2: cells were exposed to ethanol for 24 h; also, Caco-2 cells without compounds were used as absolute control.
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PMC9250505
|
F IF analysis: representative images of fluorescent DNA damage markers γH2AX and RAD51 in CAOV2 cells were treated with NPB (N), Olaparib (O), or a combination (N + O) for 16 h are taken by confocal microscope.
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PMC11806818
|
Reprinted with permission from . (
|
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PMC10125312
|
On the other hand, Hek293 had an IC50 of almost 15 nM, showing high resistance to AuNR-PEG.
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] |
PMC11683130
|
Schematic representation of the regulatory mechanism of Serpin protein in psoriasis.
|
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] |
PMC10891340
|
Samples were reverse transcribed using the Hifair III 1st Strand cDNA Synthesis SuperMix for qPCR (YEASEN, Shanghai, China).
|
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PMC11696659
|
Discreet TAV that analyse the differences between the 1st and the 99th percentiles of the telomere lengths of a sample (P1-99), or the interquartile of the telomere lengths of a sample (p25-75) also showed significant differences in the cancer versus control cohorts (p < 0.0001 in both cases) (Fig. 3A and B).
|
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PMC8348645
|
It is cultivated at a high altitude of 1500 m. It is usually grown in the frequently drought-stricken central and southern states of India .
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] |
PMC11468365
|
As observed from Table 9, the MTDL model outperforms single-task learning.
|
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PMC11791478
|
Tissue factor (TF) is overexpressed in various cancers and is typically associated with poor clinical outcomes.
|
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"O",
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] |
PMC11496491
|
GO enrichment analysis results show the top 20 terms that are most significant in terms of molecular function.
|
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"O",
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}
] |
PMC9960565
|
Then, absorbance was measured at 550 nm using a Victor 1420 PerkinElmer microplate reader.
|
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"O",
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PMC11638288
|
Previous studies have indicated that NKp46 primarily promotes NK cell-mediated killing of tumor cells by interacting with its ligands such as ecto-CRT and heparan sulfate .
|
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"O",
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"and",
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}
] |
PMC10538569
|
To determine the phenotype of iDCs, monocyte-derived iDCs were incubated with PE-conjugated anti-CD83, CD86, DC-SIGN, or HLA-DR, and FITC-conjugated anti-CD14 and APC-conjugated anti-CD3, CD11c antibodies (BD BioSciences) for 45 min on ice.
|
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] |
PMC11725127
|
After centrifugation at 12,000 × g for 30 min, the supernatant was collected.
|
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PMC9429973
|
M. Mahbub, N. Chauhan Haematologiy, Royal Free Hospital, London, United Kingdom Background: Bone marrow aspirate and trephine biopsy (bone marrow biopsy) are an establised test to diagnose haematological disease.
|
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"test",
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"disease",
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}
] |
PMC9388315
|
Glucose intake for 5637 cells from media after 24 h treatment was significantly decreased in all used concentrations (P < 0.01) (Figure 6(a)).
|
[
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"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
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"<",
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"6(a",
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}
] |
PMC9621239
|
Three dimensional structures of wild-type HBx, mutant HBx and MYC are displayed respectively at the top of the panel.
|
[
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"tags": [
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"panel",
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]
}
] |
PMC9884169
|
The morphological changes of cells with knockdown of MCT4 were determined by TEM.
|
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"O",
"O",
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"with",
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"TEM",
"."
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}
] |
PMC10882807
|
For example, circ_103809 targets miR-620 to suppress proliferation and invasion in HCC , and hsa_circ_104348 modulates the miR-187-3p/RTKN2 axis in hepatocellular carcinoma progression .
|
[
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"O",
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"in",
"hepatocellular",
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"progression",
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]
}
] |
PMC11451940
|
Complex 7 induced significant autophagy in A2780 cells; therefore, the most probable mechanism of its action relates to the induction of metabolic stress in A2780 cells.
|
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PMC9429973
|
Grade 3-4 mucositis and enteropathy was reported in 2 patients (4.6%) and 6 (14%), respectively.
|
[
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"O",
"O",
"O",
"O",
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"O",
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}
] |
PMC11391695
|
This value suggests that ACYP2, which was expressed at a low level, may possess diagnostic potential for hepatocellular carcinoma (Fig. 1E).
|
[
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"O",
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"O",
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"O",
"O",
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"O",
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]
}
] |
PMC9429973
|
S. Dong Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, China, Beijing, China Background: Immune thrombocytopenia (ITP) is an autoimmune mediated hemorrhagic disease characterized by thrombocytopenia.
|
[
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"disease",
"characterized",
"by",
"thrombocytopenia",
"."
]
}
] |
PMC11787355
|
To evaluate the extent of PTPRZ1 association with gliomas, we first examined its expression at transcript and protein levels in human glioblastoma tissues.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
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"O",
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"levels",
"in",
"human",
"glioblastoma",
"tissues",
"."
]
}
] |
PMC11209164
|
Nevertheless, the potential of TPF as a potentiator of oncolytic virus and viral vector-based gene delivery more generally warrants further pre-clinical exploration.
|
[
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"O",
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"O",
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"O",
"O",
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"O",
"O",
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"O",
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"more",
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"warrants",
"further",
"pre-clinical",
"exploration",
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]
}
] |
PMC9429973
|
The MPN SAF or MPN 10 (Myeloproliferative Neoplasm Symptom Assessment Form) questionnaire is a validated tool for assessing the symptoms presented by patients with MPN, and their evolution during treatment.
|
[
{
"tags": [
"O",
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"O",
"O",
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"O",
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"O",
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"O",
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"and",
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"evolution",
"during",
"treatment",
"."
]
}
] |
PMC11683130
|
Mutations in the SerpinB9 gene may contribute to the development of autoinflammatory diseases (121).
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"the",
"development",
"of",
"autoinflammatory",
"diseases",
"(",
"121",
")",
"."
]
}
] |
PMC11306331
|
Statistical test: Mann–Whitney U test.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"Statistical",
"test",
":",
"Mann",
"–",
"Whitney",
"U",
"test",
"."
]
}
] |
PMC9429973
|
Aims: Our aim was to identify factors that may predict a lymphoma diagnosis at the time of CT, prior to diagnostic biopsy.
|
[
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"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"time",
"of",
"CT",
",",
"prior",
"to",
"diagnostic",
"biopsy",
"."
]
}
] |
PMC11300085
|
Chemerin is a newly described adipokine with significant effects on obesity, metabolic disorders, and immune trafficking.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"a",
"newly",
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"adipokine",
"with",
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",",
"metabolic",
"disorders",
",",
"and",
"immune",
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"."
]
}
] |
PMC4395774
|
Within the synapse, there is exocytosis of specialized granules that mediate cell cytotoxicity.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"there",
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"exocytosis",
"of",
"specialized",
"granules",
"that",
"mediate",
"cell",
"cytotoxicity",
"."
]
}
] |
PMC11698348
|
To assess the effects of loss of Elf5 on keratinocyte differentiation, we performed siRNA control and siElf5 knockdown in PMEKs for 48hrs, as described above, followed by calcium induced keratinocyte differentiation, as stated above, for additional 48-hours post transfection before cells were collected for further analyses.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
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"for",
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"48-hours",
"post",
"transfection",
"before",
"cells",
"were",
"collected",
"for",
"further",
"analyses",
"."
]
}
] |
PMC8735881
|
Consistently, CMI02 and CMI06 also rendered the modified 293FTTarget cells fully resistant to the fusion mediated by a panel of HIV-1 Envs that were resistant to GPI-10E8 (Figure 7(G)).
|
[
{
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
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"to",
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"Figure",
"7(G",
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")",
"."
]
}
] |
PMC11727062
|
There is a clear need for further research into the potential of herbal monomers as both novel clinical therapies for melanoma and as components of combination treatments.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"monomers",
"as",
"both",
"novel",
"clinical",
"therapies",
"for",
"melanoma",
"and",
"as",
"components",
"of",
"combination",
"treatments",
"."
]
}
] |
PMC11449273
|
We performed invasion assays only since in vitro cell invasion is a representative of the final stage of in vivo metastasis, following cell migration.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
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"performed",
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"assays",
"only",
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"in",
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"the",
"final",
"stage",
"of",
"in",
"vivo",
"metastasis",
",",
"following",
"cell",
"migration",
"."
]
}
] |
PMC9429973
|
Results: We found the following frequencies of mutant alleles in Hodgkin’s Lymphoma patients: GSTP1313G – 31.17%, GSTP1 341T – 9.7%, MDR1 1236T – 50.00%, MDR1 2677T – 48.70%, MDR13435 ТОНН – 58.44%.
|
[
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
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"O",
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"MDR1",
"2677",
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"48.70",
"%",
",",
"MDR13435",
"ТОНН",
"–",
"58.44",
"%",
"."
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}
] |
PMC11684269
|
ACC1 catalyzes the first rate-limiting step in the synthesis of palmitic acid.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"ACC1",
"catalyzes",
"the",
"first",
"rate-limiting",
"step",
"in",
"the",
"synthesis",
"of",
"palmitic",
"acid",
"."
]
}
] |
PMC11502327
|
Compared with traditional drug delivery methods, functionalized nanoparticles can strongly inhibit endogenous miR-21 expression through endocytosis.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Compared",
"with",
"traditional",
"drug",
"delivery",
"methods",
",",
"functionalized",
"nanoparticles",
"can",
"strongly",
"inhibit",
"endogenous",
"miR-21",
"expression",
"through",
"endocytosis",
"."
]
}
] |
PMC11798926
|
For analysis, the amount of eluted interacting protein (in most cases, a myc-tagged SynDIG construct) was normalized to both the amount of eluted interacting protein (in most cases, an HA-tagged μ2 subunit) and to the amount of input interacting protein (in most cases, a myc-tagged SynDIG construct).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"in",
"most",
"cases",
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"a",
"myc-tagged",
"SynDIG",
"construct",
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]
}
] |
PMC11040965
|
Mann–Whitney U test.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Mann",
"–",
"Whitney",
"U",
"test",
"."
]
}
] |
PMC11502066
|
A decrease in the migratory and invasive potential of these androgen-independent prostate cancer cells was achieved also using the flavanonol dihydromyricetin or ampelopsin (Figure 1) via downregulation of the CXCR4 protein expression.
|
[
{
"tags": [
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"Figure",
"1",
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"via",
"downregulation",
"of",
"the",
"CXCR4",
"protein",
"expression",
"."
]
}
] |
PMC9429973
|
Aims: The primary objective was to retrospectively examine the predictive accuracy of different survival models for estimating OS of CAR T cell therapies in LBCL using data cutoffs with different follow-up durations from the respective studies.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Aims",
":",
"The",
"primary",
"objective",
"was",
"to",
"retrospectively",
"examine",
"the",
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"accuracy",
"of",
"different",
"survival",
"models",
"for",
"estimating",
"OS",
"of",
"CAR",
"T",
"cell",
"therapies",
"in",
"LBCL",
"using",
"data",
"cutoffs",
"with",
"different",
"follow-up",
"durations",
"from",
"the",
"respective",
"studies",
"."
]
}
] |
PMC9424261
|
Collectively, our findings suggesting that CA is a candidate component for the development of treatments against liver cancer.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
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",",
"our",
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"suggesting",
"that",
"CA",
"is",
"a",
"candidate",
"component",
"for",
"the",
"development",
"of",
"treatments",
"against",
"liver",
"cancer",
"."
]
}
] |
PMC4659567
|
The reaction mixture was stirred at ambient temperature for 20 min (reactions with 5Braza and 5Faza), 2 h (reactions with aza, 3Iaza and 3Claza) or 3 h (reactions with 2Me4Claza, 3Cl5Braza and 3I5Braza), until the yellow (for 2, 4 and 5), or light (for 8) or dark (for 1, 3, 6 and 7) orange product was formed.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
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"reaction",
"mixture",
"was",
"stirred",
"at",
"ambient",
"temperature",
"for",
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"and",
"5Faza",
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",",
"2",
"h",
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"with",
"aza",
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"3Iaza",
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"or",
"3",
"h",
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"reactions",
"with",
"2Me4Claza",
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"3Cl5Braza",
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",",
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"the",
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"for",
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",",
"4",
"and",
"5",
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",",
"or",
"light",
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"for",
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"dark",
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"for",
"1",
",",
"3",
",",
"6",
"and",
"7",
")",
"orange",
"product",
"was",
"formed",
"."
]
}
] |
PMC4355729
|
The cells that migrated to the lower surface of each membrane were stained and counted under a light microscope in in five fields/well.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"cells",
"that",
"migrated",
"to",
"the",
"lower",
"surface",
"of",
"each",
"membrane",
"were",
"stained",
"and",
"counted",
"under",
"a",
"light",
"microscope",
"in",
"in",
"five",
"fields/well",
"."
]
}
] |
PMC9429973
|
In addition, BrdU incorporation and cell cycle analysis was evaluated to assess cell proliferation.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"addition",
",",
"BrdU",
"incorporation",
"and",
"cell",
"cycle",
"analysis",
"was",
"evaluated",
"to",
"assess",
"cell",
"proliferation",
"."
]
}
] |
PMC11694346
|
Traditional methods for biothiol detection often lack sensitivity, specificity, or compatibility with live-cell imaging.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Traditional",
"methods",
"for",
"biothiol",
"detection",
"often",
"lack",
"sensitivity",
",",
"specificity",
",",
"or",
"compatibility",
"with",
"live-cell",
"imaging",
"."
]
}
] |
PMC4816271
|
Stability of muK666 vs huK666 CARs.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Stability",
"of",
"muK666",
"vs",
"huK666",
"CARs",
"."
]
}
] |
PMC11087766
|
Nuclear localization of the sfGFP-tagged protein was called if the highest intensity of GFP signal overlapped with the phage genome.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Nuclear",
"localization",
"of",
"the",
"sfGFP-tagged",
"protein",
"was",
"called",
"if",
"the",
"highest",
"intensity",
"of",
"GFP",
"signal",
"overlapped",
"with",
"the",
"phage",
"genome",
"."
]
}
] |
PMC9429973
|
B. Andemariam, A. Inati, R. Colombatti, C. Minniti, C. Brown, M. Hottmann, S. Gray, C. Hoppe, M. Davis, P. Yue New England Sickle Cell Institute, University of Connecticut Health, Farmington, United States of America; Lebanese American University, Byblos and Beirut, Nini Hospital, Tripoli, Lebanon; Clinic of Pediatric Hematology Oncology, Department of Woman’s and Child’s Health, Azienda Ospedale – Università di Padova, Padua, Italy; Albert Einstein College of Medicine, Bronx; Aflac Cancer and Blood Disorder Center of Children’s Healthcare of Atlanta and Department of Pediatrics, Emory School of Medicine, Atlanta; Global Blood Therapeutics, South San Francisco, United States of America Background: Sickle cell disease (SCD) is a group of autosomal recessive red blood cell (RBC) disorders caused by a single point mutation in the β-globin gene, resulting in the production of hemoglobin S. Hemoglobin S polymerization within deoxygenated RBCs contributes to hemolysis, vaso-occlusion, and end-organ damage.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"B.",
"Andemariam",
",",
"A.",
"Inati",
",",
"R.",
"Colombatti",
",",
"C.",
"Minniti",
",",
"C.",
"Brown",
",",
"M.",
"Hottmann",
",",
"S.",
"Gray",
",",
"C.",
"Hoppe",
",",
"M.",
"Davis",
",",
"P.",
"Yue",
"New",
"England",
"Sickle",
"Cell",
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"University",
"of",
"Connecticut",
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"Farmington",
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"Lebanese",
"American",
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"Byblos",
"and",
"Beirut",
",",
"Nini",
"Hospital",
",",
"Tripoli",
",",
"Lebanon",
";",
"Clinic",
"of",
"Pediatric",
"Hematology",
"Oncology",
",",
"Department",
"of",
"Woman",
"’s",
"and",
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"’s",
"Health",
",",
"Azienda",
"Ospedale",
"–",
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"di",
"Padova",
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"Padua",
",",
"Italy",
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"Albert",
"Einstein",
"College",
"of",
"Medicine",
",",
"Bronx",
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"Aflac",
"Cancer",
"and",
"Blood",
"Disorder",
"Center",
"of",
"Children",
"’s",
"Healthcare",
"of",
"Atlanta",
"and",
"Department",
"of",
"Pediatrics",
",",
"Emory",
"School",
"of",
"Medicine",
",",
"Atlanta",
";",
"Global",
"Blood",
"Therapeutics",
",",
"South",
"San",
"Francisco",
",",
"United",
"States",
"of",
"America",
"Background",
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"Sickle",
"cell",
"disease",
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"SCD",
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"is",
"a",
"group",
"of",
"autosomal",
"recessive",
"red",
"blood",
"cell",
"(",
"RBC",
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"disorders",
"caused",
"by",
"a",
"single",
"point",
"mutation",
"in",
"the",
"β-globin",
"gene",
",",
"resulting",
"in",
"the",
"production",
"of",
"hemoglobin",
"S.",
"Hemoglobin",
"S",
"polymerization",
"within",
"deoxygenated",
"RBCs",
"contributes",
"to",
"hemolysis",
",",
"vaso-occlusion",
",",
"and",
"end-organ",
"damage",
"."
]
}
] |
PMC11261875
|
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: none
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"authors",
"declare",
"the",
"following",
"financial",
"interests/personal",
"relationships",
"which",
"may",
"be",
"considered",
"as",
"potential",
"competing",
"interests",
":",
"none"
]
}
] |
PMC9429973
|
If the MFI had not decreased <2000U, two further cycles of single volume plasmapheresis and anti-CMV hyperimmune immunoglobulin 100mg/kg were given on D+1 and D+2.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"If",
"the",
"MFI",
"had",
"not",
"decreased",
"<",
"2000U",
",",
"two",
"further",
"cycles",
"of",
"single",
"volume",
"plasmapheresis",
"and",
"anti-CMV",
"hyperimmune",
"immunoglobulin",
"100mg/kg",
"were",
"given",
"on",
"D+1",
"and",
"D+2",
"."
]
}
] |
PMC6892818
|
As positive controls for TRAF1 (a), TRAF2 (b) and TRAF3 (c) protein expression induction, in RCC cell immunoblotting experiments (top panels) lysates from HCT116 cells that were treated with control (‘C’) or treated with mCD40L (‘mL’) for 6 h were included, while for HRPT cell experiments (bottom panels) lysates from ACHN cells untreated or treated with mCD40L for 6 h were used.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"As",
"positive",
"controls",
"for",
"TRAF1",
"(",
"a",
")",
",",
"TRAF2",
"(",
"b",
")",
"and",
"TRAF3",
"(",
"c",
")",
"protein",
"expression",
"induction",
",",
"in",
"RCC",
"cell",
"immunoblotting",
"experiments",
"(",
"top",
"panels",
")",
"lysates",
"from",
"HCT116",
"cells",
"that",
"were",
"treated",
"with",
"control",
"(",
"‘",
"C",
"’",
")",
"or",
"treated",
"with",
"mCD40L",
"(",
"‘",
"mL",
"’",
")",
"for",
"6",
"h",
"were",
"included",
",",
"while",
"for",
"HRPT",
"cell",
"experiments",
"(",
"bottom",
"panels",
")",
"lysates",
"from",
"ACHN",
"cells",
"untreated",
"or",
"treated",
"with",
"mCD40L",
"for",
"6",
"h",
"were",
"used",
"."
]
}
] |
PMC11753949
|
To this aim, cultured DIV7 neurons were transduced with AAV2/9 viruses encoding EGFP-synaptopodin and cells showing high abundance of these fluorescent structures were selected for analysis by correlative light and electron microscopy (CLEM).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"To",
"this",
"aim",
",",
"cultured",
"DIV7",
"neurons",
"were",
"transduced",
"with",
"AAV2/9",
"viruses",
"encoding",
"EGFP-synaptopodin",
"and",
"cells",
"showing",
"high",
"abundance",
"of",
"these",
"fluorescent",
"structures",
"were",
"selected",
"for",
"analysis",
"by",
"correlative",
"light",
"and",
"electron",
"microscopy",
"(",
"CLEM",
")",
"."
]
}
] |
PMC9874064
|
Tumor growth inhibition curves of nude mice bearing PDX tumors treated with different drugs, ∗∗∗p < 0.001 (ordinary two-way ANOVA).
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Tumor",
"growth",
"inhibition",
"curves",
"of",
"nude",
"mice",
"bearing",
"PDX",
"tumors",
"treated",
"with",
"different",
"drugs",
",",
"∗∗∗p",
"",
"<",
"0.001",
"(",
"ordinary",
"two-way",
"ANOVA",
")",
"."
]
}
] |
PMC11596967
|
This dual nature of antioxidant and pro-oxidant activity becomes more pronounced under conditions of radiation exposure, disrupting the balance between protective and damaging effects.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"This",
"dual",
"nature",
"of",
"antioxidant",
"and",
"pro-oxidant",
"activity",
"becomes",
"more",
"pronounced",
"under",
"conditions",
"of",
"radiation",
"exposure",
",",
"disrupting",
"the",
"balance",
"between",
"protective",
"and",
"damaging",
"effects",
"."
]
}
] |
PMC11186948
|
Cellular pellets were washed two times in PBS and centrifuged 5 min 2,500-3,000 rpm at 4 °C, resuspended in cold S300 buffer (50 mM HEPES pH 7.6, 300 mM NaCl, 0.1% NP40, 2 mM MgCl2, 10% glycerol) supplemented with protease inhibitors cocktail (P8340, Sigma-Aldrich) and nuclease (SC-202,391, Santa-Cruz Biotechnology) and left on ice for 1 h. Samples were centrifuged at maximum speed (13,000 rpm) for 10 min at 4 °C and the supernatant was quantified with Bradford assay (Bio-Rad) following the manufacturer’s instructions.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Cellular",
"pellets",
"were",
"washed",
"two",
"times",
"in",
"PBS",
"and",
"centrifuged",
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"min",
"2,500",
"-",
"3,000",
"rpm",
"at",
"4",
"°",
"C",
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"resuspended",
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"cold",
"S300",
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"50",
"mM",
"HEPES",
"pH",
"7.6",
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"300",
"mM",
"NaCl",
",",
"0.1",
"%",
"NP40",
",",
"2",
"mM",
"MgCl2",
",",
"10",
"%",
"glycerol",
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"supplemented",
"with",
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"P8340",
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"Sigma-Aldrich",
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"and",
"nuclease",
"(",
"SC-202,391",
",",
"Santa-Cruz",
"Biotechnology",
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"and",
"left",
"on",
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"for",
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"h.",
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"centrifuged",
"at",
"maximum",
"speed",
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"13,000",
"rpm",
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"for",
"10",
"min",
"at",
"4",
"°",
"C",
"and",
"the",
"supernatant",
"was",
"quantified",
"with",
"Bradford",
"assay",
"(",
"Bio-Rad",
")",
"following",
"the",
"manufacturer",
"’s",
"instructions",
"."
]
}
] |
PMC11798926
|
Data are represented as mean ± SEM; n = 11–15 cell per group, each group from 2 to 3 independent experiments; ns not significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.
|
[
{
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
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";",
"*",
"*",
"*",
"*",
"p",
"<",
"0.0001",
"."
]
}
] |
PMC11588008
|
Gently disperse the cell suspension, transfer it to 10 mL centrifuge tubes using a pipette, centrifuge at 1,000 rpm for 5 min, and discard the supernatant.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
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"tokens": [
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"the",
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"centrifuge",
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"rpm",
"for",
"5",
"min",
",",
"and",
"discard",
"the",
"supernatant",
"."
]
}
] |
PMC8143558
|
They also observed that the saponin fraction exhibited more activity against these fungal strains than bacterial strains that they included in their study.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"They",
"also",
"observed",
"that",
"the",
"saponin",
"fraction",
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"more",
"activity",
"against",
"these",
"fungal",
"strains",
"than",
"bacterial",
"strains",
"that",
"they",
"included",
"in",
"their",
"study",
"."
]
}
] |
PMC11753949
|
For CLEM, light microscopy was performed with an Andor DragonFly microscope with either a PlanApo 63X/1.4 NA oil immersion objective or a 20X air objective and equipped with a Zyla cMOS camera.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"For",
"CLEM",
",",
"light",
"microscopy",
"was",
"performed",
"with",
"an",
"Andor",
"DragonFly",
"microscope",
"with",
"either",
"a",
"PlanApo",
"63X/1.4",
"NA",
"oil",
"immersion",
"objective",
"or",
"a",
"20X",
"air",
"objective",
"and",
"equipped",
"with",
"a",
"Zyla",
"cMOS",
"camera",
"."
]
}
] |
PMC11496728
|
The above data were from three independent experiments, when P < 0.05, the difference is statistically significant, compared with CHO-WT, *P < 0.05, **P < 0.01.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"above",
"data",
"were",
"from",
"three",
"independent",
"experiments",
",",
"when",
"P",
"<",
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",",
"the",
"difference",
"is",
"statistically",
"significant",
",",
"compared",
"with",
"CHO-WT",
",",
"*",
"P",
"<",
"0.05",
",",
"*",
"*",
"P",
"<",
"0.01",
"."
]
}
] |
PMC11098378
|
After 30 min at 25°C, the reaction was quenched by the addition of 1 mM PMSF and the molecular weight of the core was determined by intact mass spectroscopic analysis (UTSW Proteomic Core), revealing a highly abundant peptide (T55-R287) corresponding to residues Thr-55-Arg287 (Ceg10) in Ceg10.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"After",
"30",
"min",
"at",
"25",
"°",
"C",
",",
"the",
"reaction",
"was",
"quenched",
"by",
"the",
"addition",
"of",
"1",
"mM",
"PMSF",
"and",
"the",
"molecular",
"weight",
"of",
"the",
"core",
"was",
"determined",
"by",
"intact",
"mass",
"spectroscopic",
"analysis",
"(",
"UTSW",
"Proteomic",
"Core",
")",
",",
"revealing",
"a",
"highly",
"abundant",
"peptide",
"(",
"T55-R287",
")",
"corresponding",
"to",
"residues",
"Thr-55-Arg287",
"(",
"Ceg10",
")",
"in",
"Ceg10",
"."
]
}
] |
PMC11551844
|
AuNPs-JDE showed the highest uptake followed by AuNPs-JDH, AuNPs-ansellone, AuNPs-control, AuNPs-JC-2 and AuNPs-contignasterol.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"AuNPs-JDE",
"showed",
"the",
"highest",
"uptake",
"followed",
"by",
"AuNPs-JDH",
",",
"AuNPs-ansellone",
",",
"AuNPs-control",
",",
"AuNPs-JC-2",
"and",
"AuNPs-contignasterol",
"."
]
}
] |
PMC6948907
|
Acetylation of the histones is a posttranslational modification found in the all animal species.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Acetylation",
"of",
"the",
"histones",
"is",
"a",
"posttranslational",
"modification",
"found",
"in",
"the",
"all",
"animal",
"species",
"."
]
}
] |
PMC11665584
|
The eschar contained mostly dead or dying cells and was excluded from Xenium analysis.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"eschar",
"contained",
"mostly",
"dead",
"or",
"dying",
"cells",
"and",
"was",
"excluded",
"from",
"Xenium",
"analysis",
"."
]
}
] |
PMC11588008
|
Levels of GSH and GSSG in ovarian cancer cells in different treatment groups, ****P < 0.0001, **P < 0.01 vs blank group, P < 0.0001, P < 0.05 vs PM group, ▫▫▫▫P < 0.0001, ▫P < 0.05 vs PM + MSC group. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Levels",
"of",
"GSH",
"and",
"GSSG",
"in",
"ovarian",
"cancer",
"cells",
"in",
"different",
"treatment",
"groups",
",",
"*",
"*",
"*",
"*",
"P",
"<",
"0.0001",
",",
"*",
"*",
"P",
"<",
"0.01",
"vs",
"blank",
"group",
",",
"P",
"<",
"0.0001",
",",
"P",
"<",
"0.05",
"vs",
"PM",
"group",
",",
"▫",
"▫",
"▫",
"▫",
"P",
"<",
"0.0001",
",",
"▫",
"P",
"<",
"0.05",
"vs",
"PM",
"+",
"MSC",
"group",
".",
"("
]
}
] |
PMC11745823
|
Luciferase vectors, either wild‐type or mutant, were constructed based on HIF‐1α's potential binding site on the RIT1 promoter. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Luciferase",
"vectors",
",",
"either",
"wild‐type",
"or",
"mutant",
",",
"were",
"constructed",
"based",
"on",
"HIF‐1α",
"'s",
"potential",
"binding",
"site",
"on",
"the",
"RIT1",
"promoter",
".",
"("
]
}
] |
PMC9622879
|
Based on the functionalities of the RES and ESS, general mathematical formulas of the DERs and load for each home and the entire community are constructed and successfully transformed into an MILP problem that can be solved in a short time.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Based",
"on",
"the",
"functionalities",
"of",
"the",
"RES",
"and",
"ESS",
",",
"general",
"mathematical",
"formulas",
"of",
"the",
"DERs",
"and",
"load",
"for",
"each",
"home",
"and",
"the",
"entire",
"community",
"are",
"constructed",
"and",
"successfully",
"transformed",
"into",
"an",
"MILP",
"problem",
"that",
"can",
"be",
"solved",
"in",
"a",
"short",
"time",
"."
]
}
] |
PMC7723249
|
In this study, we compared HAZV and CCHFV infection of human polarized epithelial cells to shed light on similarities and differences in virus-host cell interaction between these two viruses.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"this",
"study",
",",
"we",
"compared",
"HAZV",
"and",
"CCHFV",
"infection",
"of",
"human",
"polarized",
"epithelial",
"cells",
"to",
"shed",
"light",
"on",
"similarities",
"and",
"differences",
"in",
"virus-host",
"cell",
"interaction",
"between",
"these",
"two",
"viruses",
"."
]
}
] |
PMC11737091
|
DBF4 mRNA expression was upregulated in ccRCC tissues (n = 541) compared with normal tissues (n = 72). (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"DBF4",
"mRNA",
"expression",
"was",
"upregulated",
"in",
"ccRCC",
"tissues",
"(",
"n",
"=",
"541",
")",
"compared",
"with",
"normal",
"tissues",
"(",
"n",
"=",
"72",
")",
".",
"("
]
}
] |
PMC11380454
|
p <0.05 was considered statistically significant.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"p",
"<",
"0.05",
"was",
"considered",
"statistically",
"significant",
"."
]
}
] |
PMC11725127
|
GA treatment can reduce the cell viability of MM.1S and RPMI 8226 cell lines. (
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-CellLine",
"O",
"B-CellLine",
"I-CellLine",
"O",
"O",
"O",
"O"
],
"tokens": [
"GA",
"treatment",
"can",
"reduce",
"the",
"cell",
"viability",
"of",
"MM.1S",
"and",
"RPMI",
"8226",
"cell",
"lines",
".",
"("
]
}
] |
PMC7433824
|
Grade I‐III gliomas showed relatively high levels of PKM2 in RNA and protein levels, whereas GBMs were found to exert an almost 3‐ to 5‐fold increase in PKM2 levels.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Grade",
"I‐III",
"gliomas",
"showed",
"relatively",
"high",
"levels",
"of",
"PKM2",
"in",
"RNA",
"and",
"protein",
"levels",
",",
"whereas",
"GBMs",
"were",
"found",
"to",
"exert",
"an",
"almost",
"3‐",
"to",
"5‐fold",
"increase",
"in",
"PKM2",
"levels",
"."
]
}
] |
PMC10965680
|
Only 1.28% of all the SNPs were found in exons, including 113,185 nonsynonymous and 101,604 synonymous SNPs.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Only",
"1.28",
"%",
"of",
"all",
"the",
"SNPs",
"were",
"found",
"in",
"exons",
",",
"including",
"113,185",
"nonsynonymous",
"and",
"101,604",
"synonymous",
"SNPs",
"."
]
}
] |
PMC11489351
|
We selected MCF10A, an immortalized mammary epithelial cell line, for the initial RNA-seq experiments.
|
[
{
"tags": [
"O",
"O",
"B-CellLine",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"We",
"selected",
"MCF10A",
",",
"an",
"immortalized",
"mammary",
"epithelial",
"cell",
"line",
",",
"for",
"the",
"initial",
"RNA-seq",
"experiments",
"."
]
}
] |
PMC11637276
|
The role of α2 integrin in pancreatic cancer remains controversial.
|
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"cancer",
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PMC11680049
|
This localization of polyphenols and terpenoids, including in Sequoia, is generally determined by their physiological functions.
|
[
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"O",
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"O",
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PMC11472569
|
The human ABC transporter family includes 48 members, classified into seven subfamilies (A to G) based on sequence homology, domain organization, and phylogenetic analysis.
|
[
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] |
PMC11366496
|
To further elucidate this issue, we conducted a series of related experiments.
|
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PMC9429973
|
Prior cardiovascular (CV) risk factors were recorded: hypertension 8/56 14%, body mass index ≥25kg/m2 32/56 57%, hyperlipidemia (>220mg/dl) 13/56 23.2%, smokers 10/56 18% and diabetes mellitus 4/56 7%.
|
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PMC11720808
|
Similar results were observed in the colony-formation assay (Figure 1E), where SCU decreased the colony number.
|
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PMC8777939
|
For colony formation, A2780 and A2780-ADR cells were seeded into 6-well plates (1000 cells per well) and were incubated with various concentrations of etravirine (0–10 µM), paclitaxel (5 nM), and a combination of 10 µM etravirine and 5 nM paclitaxel.
|
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PMC11697703
|
Imaging acquisition and neuron reconstruction were performed blinded to the experimental conditions.
|
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"O",
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}
] |
PMC11286266
|
Considering possible regulatory roles of N-glycosylation and disulphide bonds in ATF6α activation (Hong et al., 2004; Oka et al., 2019), three different versions of ATF6α_LD were used: (1) fully glycosylated ATF6α_LD (WT), (2) non-glycosylated ATF6α_LD (∆Gly), and (3) ATF6α_LD lacking its cysteines (∆C) (Figure 4A).
|
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"Figure",
"4A",
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}
] |
PMC8170755
|
Our results also revealed an inhibitory effect for VPA on the expression of MMP-2 and MMP-9 genes in the A459 cell.
|
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"O",
"O",
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"O",
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}
] |
PMC9429973
|
Multivariate analysis for PFS the results were advanced stage (HR 4.72 95%CI: 1.43-23.9, P=0.015), elevated LDH (HR 4.85 95%CI: 1.73-13.60, P=0.014) and ECOG-PS≥2 (HR 5.25 95%CI: 1.68-16.4, P=0.024).
|
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"P=0.024",
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}
] |
PMC9429973
|
Aims: To correlate variant haemoglobin pattern with phenotypic presentation at diagnosis in SCD.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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}
] |
PMC10761571
|
In addition, it was found that gingerol could arrest the cell cycle and induce apoptosis through the activation of Caspase 3, 7, 8, and 9 .
|
[
{
"tags": [
"O",
"O",
"O",
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"O",
"O",
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}
] |
PMC10553757
|
Serum GH was measured at 36 weeks’ gestation and during postpartum days 1-4.
|
[
{
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"days",
"1",
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}
] |
PMC11747467
|
ERBB2 has been reported to be highly enriched in bladder cancer and associated with poor clinical outcomes (32, 33), suggesting that it might be a promising therapeutic target.
|
[
{
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"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
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"a",
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"target",
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}
] |
PMC10213179
|
Red arrow highlights the node from protein SELEX presenting most inter-connections with aptamers from cell-internalization SELEX.(C) Isolation of the protein SELEX aptamer nodes and all directly connected nodes from both the protein and cell-internalization SELEX.
|
[
{
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}
] |
PMC11521786
|
This could potentially explain how the direct recognition of the PAbs generated by vaccination, leading to receptor degradation, causes a cytotoxic effect on tumor cells.
|
[
{
"tags": [
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
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}
] |
PMC9429973
|
No on-study deaths occurred.
|
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"tags": [
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"O",
"O",
"O",
"O"
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"tokens": [
"No",
"on-study",
"deaths",
"occurred",
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}
] |
PMC11354225
|
Finally, chemoproteomic analyses identified numerous direct targets of EGCG within cellular compartments .
|
[
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"direct",
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"within",
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"compartments",
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}
] |
PMC10747160
|
We were keenly interested in how the M protein affected DC-SIGN-mediated trans-infectivity because, based on data from three other coronaviruses (SARS-CoV-1, Mouse Hepatitis virus, and Feline coronavirus), it is estimated that the SARS-CoV-2 particle expresses ~1100 M protein dimers on its surface .
|
[
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"surface",
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}
] |
PMC3681794
|
B, Graphs show 2 where CT is the cross-threshold and represents the change in Glut-1 mRNA expression with time in 791T, HOS and U2OS cells in hypoxia relative to normoxia, where 1 would be equivalent expression in normoxia and hypoxia and greater than 1 represents an increase in hypoxia relative to normoxia.
|
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"than",
"1",
"represents",
"an",
"increase",
"in",
"hypoxia",
"relative",
"to",
"normoxia",
"."
]
}
] |
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