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OTAR3088
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BioData-CellLine_annotated

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PMC9739791
Cytotoxicity of BODI-Pt 17 was studied on several cell lines, including MCF-7, MDA-MB-231, and A2780 (Table 6).
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PMC11740573
The obtained results are preliminary and do not constitute direct evidence of the therapeutic efficacy of calcitriol in clinical settings.
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PMC10587429
Importantly, we believe this model is an improved model compared to the non-humanized model in evaluating the safety and efficacy of immunotherapy regimens as evidenced by the results of our investigation with CD47 blockade ( Figure 4 ).
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PMC9429973
Aims: We aimed to explore the effect of G-CSF mobilization on the anti-GVHD or GVL effect of MAITs.
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PMC5941560
Jurkat variants loci that have matches in dbSNP (short variants) and DGV (long variants) as percentage of total Jurkat variant sites for each type of variant.
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PMC9429973
Since hyperferritinemia was not expected in polycythemia vera and the patient was diabetic, he was examined for HH.
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PMC10933092
et al., 2021; Zheng et al., 2021; Li et al., 2022; Mao et al., 2022).
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PMC11514418
Long-term survival: The long-term survival follow-up was conducted through outpatient visits, telephone calls, or online social media platforms.
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PMC9429973
Causes of death were PCNSL in 69% of the patients (both arms), complication of treatment (6% vs 5%), secondary malignancy (5% vs 2%) and other or unknown causes (20% vs 24%).
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PMC9429973
Methods: Patients from 1 to 14 years of age who were diagnosed with higher-risk MDS and underwent allo-HSCT consecutively between February 2019 and August 2020 in Pediatric Blood Diseases Center were enrolled.
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PMC9688728
Only the hits whose forward and reverse similarity exceeded 700 were considered.
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PMC11507371
These encode stress response proteins and metabolic enzymes such as antioxidant phase II proteins (haeme oxygenase-1 (HMOX-1), NAD(P)H quinone dehydrogenase (NQO1), and CAT) .
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PMC11551844
Thus, it can be deduced that the biological activity observed with contignasterol and ansellone A and their conjugated AuNPs were cell line specific.
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PMC11632064
This suggests that the sensitivity of A-375 cells to RSK/PLK inhibitors may not be fully explained by their mutated BRAF status.
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PMC7154001
MetaboliteMetabolic PathwayEfficacy/Toxicity of MetaboliteAM6−36 (3-amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione)In vitroHLM, human hepatocyte–HPLC-QTOF-MS, HPLC-QqQ-MS1 Metabolite for HLM (4);7 Metabolites for hepatocyte (4–10)Reduction (4);Monoacetylation (5);Conversion of amino acid group to ...
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PMC11746942
Fig. 5Src mediates S1PR3-induced biphasic STAT3 activation in keratinocytes via Gαi/PKA signaling.
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PMC11766350
The backbone of this plasmid was then modified by inserting a U6 promoter-driven shRNA expression cassette, containing an anti-gfp shRNA sequence (Figure 1).
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PMC11371627
There was no myalgia at rest, during or after exercise.
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PMC8777939
The slides were blocked and incubated with primary antibodies against AGR2 (1: 500, ab76473), CD31 (1: 200, ab76533), cleaved caspase-3 (1: 500, Asp175, 9664), and PCNA (1: 5000, D3H8P, 13110) overnight at 4 °C, followed by incubation with secondary antibodies, namely, goat anti-rabbit IgG-horseradish peroxidase (HRP 1...
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PMC11337594
To gain further insight into the molecular mechanisms underlying these metabolic alterations, we examined the expression of pivotal enzymes involved in the pathway.
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PMC10994876
Furthermore, CHO cells can conduct post-translational modifications (PTM) on proteins derived from human sources (Pieper et al. 2017).
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PMC11127909
However, the cell viability assay revealed that 143BR cells had a higher IC50 than 143B cells (Fig. S2E).
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PMC8584666
These results suggested that GPI-80 expression was not related to PC3 cell growth.
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PMC11737091
The p values and HRs of statistically significant factors are shown in the forest plot.
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PMC10936243
All data held locally in Edinburgh were securely destroyed at the completion of the PhD project.
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PMC10652261
H and C NMR spectra were recorded on an NMR spectrometer (Bruker, Billerica, MA, USA).
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PMC11705862
We have recently shown that CD59 is present intracellularly in pancreatic β-cells .
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PMC11534035
Control cells formed colonies with a mean size of 24.49±0.4704 px.
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PMC11727145
This evokes evidence that the DED is particularly effective for tissue culture experiments, providing an ideal ex vivo environment to study keratinocyte adhesion and proliferation.
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PMC11680578
Carefully the aqueous phase was removed using a pipette and placed in another 1.5 ml Eppendorf tube.
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PMC11474209
Medicines and dietary supplements that target mitochondria and drive cell death may be beneficial for protection .
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PMC6450504
The nuclei stained by Hoechst allowed the quantification of total cellular DNA content and, based on nuclear area, single live cells were gated into G1, S, and G2 phases to categorize the cell cycle distribution.
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PMC11429241
We designed scaffolds with two different types of architectures to see which one mimicked the ECM better.
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PMC11519583
not significant, d, f, g: Dunnett’s test, e, h–j: Holm’s test).
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PMC11792888
According to gene expression analysis , MRC-5 and foreskin fibroblasts showed similar expression of most genes, with only a few being specific to each cell line .
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PMC10165258
The cells were cultured in a CO incubator (5% of CO , 37°C, C150, C150), on T-25, 25 cm cell-culture flask (Corning) in 5 mL of high glucose Dulbecco’s modified Eagle’s medium (DMEM + GlutaMAX, ThermoFisher), supplemented using 10% of Fetal Bovin Serum (FBS, ThermoFisher) and 1% of penicillin-streptomycin (ThermoFisher...
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PMC11611077
Briefly, SDS-PAGE was performed to CHO cells transfected with His-tagged prestin.
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PMC10421378
A 1 g sample was placed in each vial and sealed using airtight caps in one of three variants: with atmospheric air, with nitrogen, and under vacuum.
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PMC11451940
SI = the selectivity index expressed as IC50(MRC-5)/IC50(A2780).
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PMC11066331
Fig. 2Expression of TUSC3 was downregulated by shRNA transduced into the SKOV3 cells.
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PMC9429973
Novel treatments with durable responses and survival benefit are needed.
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PMC9341513
IGH-CCND1 is a common translocation observed in mantle cell lymphoma (MCL) and multiple myeloma (MM); when translocated together, the IGH super-enhancers drive CCND1 overexpression.
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PMC9429973
Two pts had IPI score 3, one had IPI score 2.
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PMC6160470
are representative of 2 independent experiments performed in duplicates.
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PMC11472639
Indeed, whilst daratumumab therapy combinations prior to a stem cell transplant achieves favourable overall response rates of 93% (Moreau et al., 2019), there is marked heterogeneity in responses.
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PMC11684269
To be precise, in antitumor immunity, canagliflozin could dramatically hinder PD-L1 expression, thus enhancing CD8 T cell-mediated cytotoxicity (121).
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PMC11055510
FISH analysis manifested that circMAN1A2 co-localized with miR-135a-3p in OC cells (Fig. 3G). (
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PMC8345486
Cell line authentication involving short tandem repeat profiling (STR) was performed by the European Collection of Authenticated Cell Cultures (ECACC) and Eurofins Genomics Services.
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PMC11767725
Lipid peroxidation products like malondialdehyde generated under oxidative stress further enhance inflammatory cascades.
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PMC9509578
These green synthesized nanomaterials are prepared by using different plant parts, natural compounds, and microorganisms.
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PMC11757131
Additionally, the concentrations of unsaturated fatty acids such as C16:1, C18:2, C20:3, and C20:4 in the cells were higher in the 3-HIB-supplemented group compared than in the control group (p < 0.05).
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PMC11297139
Nuclei were stained with DAPI.
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PMC10158546
Antibodies: rabbit-anti-NES (1:250, Abcam ab105389), mouse-anti-TUBB3 (1:300, Abcam ab78078), rabbit-anti-GFAP (1:1,000, DAKO Z0334), chicken-anti-PrP (1:300, Abcam ab178545), goat-anti-rabbit-Alexa488 (1:1,000, Abcam ab6150077), goat-anti-mouse-Alexa568 (1:250, ThermoFisher A11004), goat-anti-chicken-Alexa647 (1:250, ...
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PMC10243817
However, TGF-β2 has a low affinity for binding to TGF-βR2.
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PMC9429973
Results: The SLR identified 2997 citations, from which 148 studies were selected for investigation.
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PMC11607764
Finally, the intersection of 100 bindings and 50 interacted genes was obtained using the Ugent web tool (https://bioinformatics.psb.ugent.be/webtools/Venn/).
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PMC9429973
Weighted Wald tests and 95% confidence intervals were computed for comparisons of categorical and continuous outcomes.
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PMC11678448
Our data further indicate that the JAK-STAT signaling pathway is particularly active in our observations, highlighting its importance in the immune response to P. multocida.
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PMC9429973
The accumulative incidence of III-IV aGVHD and severe cGVHD of patients in the MSCs group significantly decreased, which is 3.1% and 6.3%, while the control group is 25.6% and 18.8% (P=0.0089 and P=0.0260).
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PMC9164404
We continued to evaluate the killing effect of Abplatin.
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PMC8557138
Elevated expression of angiocrine molecules in the tumor niche is often coupled with the downregulation of anti-angiogenic molecules such as endostatin, matrix metalloproteinases (MMP) inhibitors, tissue inhibitors of metalloproteinases (TIMPs), thrombospondin-1 and interferon-alpha (IFN-α) (Ren et al. 2006; Wong et al...
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PMC11754094
Within the non-TC target, P = 0.0288 for ABE, P = 0.0685 for ABE-UGI and P = 0.0002 for AYBE compared to nCas9 (D10A).
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PMC7759933
Previously, in encapsulated 3D HepG2 aggregates, no necrotic core was observed up to three days of culturing, while with prolonged cultivation, the thickness of aggregates disabled the determination of necrotic cells in the centre of the 3D cell model .
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PMC11680982
The primary antibodies used in this study included rabbit antibody HER2 (1:6000; 18299-1-AP, Proteintech, China), rabbit antibody Cyclin D1 (1:1000; 2922 S, Cell Signaling Technology, USA), rabbit antibody CDK4 (1:1000; sc-23896, Santa Cruz, USA), mouse antibody EGFR (1:1000; 66455-1-PBS, Proteintech, China), and mouse...
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PMC9429973
Summary/Conclusion: Several barriers to and facilitators for implementation were identified, a clear overview was presented, and a unique comprehensive implementation guide was developed for lancing future digital care platforms in daily clinical practice.
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PMC11794588
Subramanian et al.found that cedryl acetate exhibited cytotoxic effects in brine shrimp assays, suggesting it may disrupt cellular integrity Cedryl acetate’s cytotoxic effects in brine shrimp may be related to its ability to induce apoptosis or cell membrane disruption.
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PMC9429973
There wasn’t transplantation related mortality.
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PMC11471176
To attain a 10-fold dilution of the designated test concentration, the solution was diluted using Assay Buffer XI/ACE2 Assay Buffer.
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PMC11473750
Cells were washed with cold PBS after treatment and harvested.
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PMC10568263
The other two peak values of 646.2 and 658.1 eV are attributed to Mn.
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PMC10470467
To further investigate the difference in response to immunotherapy between distinct risk groups, one immunotherapeutic cohort from the “IMvigor210” R package, which investigated the efficacy of anti-PD-L1 antibody in patients with advanced urothelial cancer, was also included in our study as an external validation data...
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PMC11406030
Notably, most tumors (67.5%) exhibited strong nuclear LMTK3 staining (Table 1).
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PMC9014716
The cell clone formation assay (Figure 1I–K) showed that the number of clones in the combined treatment group was significantly lower than in the OXA group, indicating greater inhibition of cell proliferation in the PS-T + OXA group than the OXA group.
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PMC9878278
We also compared the effect of MDA5 knockout on ZIKV replication in A549 cells.
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PMC11515150
T-lymphoblastic lymphoma encompasses biological properties akin to T-ALL.
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PMC10212663
The Kaplan–Meier method was applied to evaluate the relationship between different variables and survival if not specified, and differences between survival curves were judged by the log‐rank test.
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PMC11344246
The subgraphs that PCSF identifies aim to maximise the number of mutated genes covered while minimising the edge cost to promote sparsity.
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PMC8140214
GPx is another enzyme responsible for dissociation of H2O2 into H2O via GSH in both cytoplasm and extracellular fluid of allhuman tissues.
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PMC7762347
Three independent experiments were performed.
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PMC10747160
To do so, 1.7 μg of desired M, N, or E protein vector was added to the transfection mixture specified above: pcDNA3.1 SARS-CoV-2 M (Addgene Cat # 158078), pcDNA3.1 SARS-CoV-2 N (Addgene Cat # 158079), and pcDNA3.1 SARS-CoV-2 E (Addgene Cat # 158080), respectively.
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PMC4369959
It has also shown that ginger extract synergistically increases the apoptotic efficacy of Gelam honey .
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PMC9429973
Obesity, renal failure and a high risk (according to the Sanz score) represented an indication for a DS prophylaxis prescription, using whether prednisone (LPA99) or dexamethasone (LPA2005).
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PMC11705862
Values are expressed as a mean ± SD.
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PMC10547921
Michel O. Steinmetz's team found through the crystal structure that the binding site of eribulin to tubulin is shaped by the hydrophobic and polar residues of helices H1, H6, H7, loops H6–H7, S3–H3 (T3), and S5–H5 (T5) of β-tubulin (Fig. 5B).
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PMC11532793
We used the simulation framework from Baldoni et al. (13) to assess differences between bootstrap and Gibbs sampling in regard to DTE assessment.
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PMC9509578
Smart nanomaterials utilize the physiological characteristics of the tumor cells and respond according to the tumor microenvironment, thus offering more effective treatment than conventional chemotherapy.
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PMC11206251
This study analyzed the chemical constituents of the PEIM by LC-MS/MS and investigated the effect of the PEIM against HCC, showing that a total of 64 compounds were identified, including flavonoids, diterpenoids, triterpenoids, alkaloids, lignans, and sesquiterpenoids, which are believed to play a crucial role in treat...
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PMC11348300
Protoporphyrin IX (PpIX) is a molecular fluorophore that has been utilized effectively in skin lesion, bladder cancer, and glioma tissue resection guidance and is examined here as a tissue-oxygen contrast tool.
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PMC11763111
Heat maps were generated based on DEGs filtered by [Log2FC] > 1 and FDR p-value < 0.05, with DEG heat maps constructed using TBtools (RRID:SCR_023018).
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PMC11365427
RT-qPCR shows the mRNA expression levels of ATF3, DDIT3, and TNFRSF10B genes in NCI-H929 and RPMI-8226 cells after 48 h of phenylalanine deprivation with siATF3 transfection. (
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PMC9429973
These results were also mirrored in vivo on TPO Zebrafish (Danio rerio) model.
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PMC9031474
Because of their cytotoxic activity, these sesquiterpenoids have received increasing attention as a source for new anticancer drugs and pharmacophores.
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PMC4005030
PCA has been reported for its potential action such as antioxidant activity, antibacterial activity, anticancer activity, antiulcer activity, antidiabetic activity, antiageing activity, antifibrotic activity, antiviral activity, anti-inflammatory activity, analgesic activity, antiatherosclerotic activity, cardiac activ...
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PMC9429973
Summary/Conclusion: These first data demonstrate that treatment with HD-MTX and Glucarpidase is feasible in pts with CNSL and impaired renal function.
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PMC9429973
D. M. Akkurd, H. Haydaroglu Sahin, E. Yilmaz, V. Okan Haematology department, Gaziantep University Sahinbey Research And Practice Hospital, Gaziantep, Turkey Background: Multiparametric flow cytometry-based immunophenotyping is a useful tool for the diagnosis and monitoring of multiple myeloma.
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PMC9429973
Overall response rate was 96%, including 92 % ≥ very good partial response.
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PMC11515150
In the study, the average % CAR transduction was 64.2% from three healthy donors with K562 feeder system (data not shown), this high transduction facilitates the clinical application of nanobody-derived CAR-NK cell derived from PB.
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PMC6934009
Disturbance of equilibrium between anti-oxidants and ROS in the cells leads to oxidative stress (6).
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PMC11627133
To ensure minimal interference between aptamer‐ and antibody‐based methods, we utilized GFP‐binding AP3‐RhoBAST, while an anti‐synaptophysin antibody directly targeted synaptophysin.
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PMC11703992
The Uniform Manifold Approximation and Projection (UMAP) method was used for dimension reduction and cell clustering.
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