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PMC11607764
From incidence of tumor relapse and survival perspective, high PTBP1 expression was correlated with worse clinical outcome in non–muscle-invasive bladder cancer.
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PMC10154881
These results indicated that rMV‐cancer therapy induced a tumor antigen‐specific CD8 T‐cell response.
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PMC11665584
PITX1 keratinocytes had a moderate increase in Wnt gene expression.
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PMC9429973
H. Fernandez Leyva Haematology, NHS, Licoln, United Kingdom Background: There is universal concern about the inappropriate use of fresh frozen plasma (FFP).
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PMC11754432
Western analysis is relative to control siRNA and normalised to loading control (N = 3).
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PMC10317042
A, CCS cells were treated with 0, 0.3, 1.0, 3.0, or 10.0 μmol/L vorinostat for 24 hours.
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PMC9429973
The cumulative incidence of HCMV and refractory HCMV infection for patients in NK infusion cohort were significantly reduced compared with control cohort (figure 1c).
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PMC9587866
The screened compounds were further analyzed to record the effects on gene targets and A673 lines, using in silico prediction databases.
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PMC8956657
n = 3 biologically independent experiments.
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PMC9429973
The event free survival was 33.3 months for patients who have been seen regularly.
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PMC9479186
Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial respiratory chain.
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PMC11747467
These data suggested a feasible therapeutic strategy for RC48 against urothelial carcinoma.
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PMC11506827
Notably, TRAIL treatment alone noticeably increased the number of TUNEL-positive A498 cells, indicating sensitivity to TRAIL-induced apoptosis.
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PMC11513571
Briefly, peripheral blood mononuclear cells (PBMCs) were separated using Ficoll-Paque (Sigma-Aldrich), centrifuged at 400g for 25 min, and washed with cold PBS (containing 1% bovine serum albumin (BSA) for 10 min.
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PMC6461034
Centrifuge 30 s at 2,000 × g and 4°C, and remove supernatant, allowing some remaining liquid on the beads.
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PMC11604768
Serotonin treatment in cells expressing 5-HT2A induced transcription from many promoters, including those containing THRB-1 and SRE units.
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PMC11727907
These results agree with previous evidence showing that AKT mediates the effects of IGF-1 on PKM2 function .
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PMC10547921
Figure 6Design and SAR analysis of tubulysin analogs. (
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PMC6771295
One-way analysis of variance (ANOVA) and Tukey's multiple comparisons post-test were used for the analysis of data.
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PMC8839885
A2780CisR cells co-cultured with MS-5 and treated with RJY13 (5 μM) and combined with 10 μM of pharmaceutical inhibitors for 24 h. Cell lysates were used to monitor levels of cleaved PARP using PARP ELISA kit .
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PMC11126803
Although the estrogen receptor (ER) can promote initiation and progression of renal cell carcinoma (RCC), how the downstream biomolecules are involved, and the detailed mechanisms of how ER expression is elevated in RCC remain to be further elucidated.
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PMC8584319
We tested the role of ERK1/2 in AZD8055-mediated inhibition of protein synthesis and found no inhibitory effect on protein synthesis following single treatment with refametinib; however, co-treatment with AZD8055 and refametinib could significantly down-regulate the protein synthesis pathway after 8 h (Figure 4a,c), a ...
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PMC11451940
In the meantime, the commercial precursor Cu(NO3)2·3H2O (or Zn(NO3)2·6H2O) and the corresponding N–N ligand were dissolved in a MeOH/H2O mixture volume (1 : 1 v/v) in a 1 : 1 molar ratio and stirred at room temperature for 20 minutes, giving a light blue solution.
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PMC9712534
Representative images of FRAP analysis of EGFP-TOP2B H58Y in the presence of ICRF-187.
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PMC11190238
The epithelial cells are connected to the underlying basement membrane via hemidesmosomes, which contains integrin that facilitates binding to the basement membrane and is also linked to cytokeratins within the cell.
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PMC10854447
For more information, see Appendix A. Compounds 7j, 7k, and 7l, the most potent derivatives in all in vitro studies, were tested for their capacity to initiate the apoptosis cascade and reveal their proapoptotic potential.
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PMC6468656
However, ghrelin’s activity in promoting cell invasion remains obscure.
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PMC9895440
The data is deposited under GEO210535, the full analysis pipeline can be found on GitHub/Zenodo [10.5281/zenodo.7307407] and supplementary information is found in Supplementary Data 5.
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PMC6461034
The results of INKA highlight kinases that are in line with known cancer biology and show that INKA scoring clearly outperforms substrate‐centric analyses alone, and also holds a slight edge over phosphokinase ranking pioneered by Rikova et al (2007) and over KARP (Wilkes et al, 2017).
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PMC8777939
After washing three times with 1X assay buffer, these cells were analyzed by using Lion Heart FX automatic microscope (Biotek, Winooski, VT, USA) (scale bar = 100 µM).
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PMC11721064
The analysis entails three key steps: (1) identification of candidate target genes based on co-expression networks, (2) recognition of directly accessible genes through motif analysis to construct regulons (groups of co-regulated genes), and (3) scoring of all regulons.
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PMC9429973
In the multivariable analysis, patients with regular hospital visits had lower relapse rates and higher survival rates than did those with irregular hospital visits in terms of PFS and OS (hazard ratio (HR) = 1.95, p < 0.001; HR =2.80, p < 0.001, respectively).
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PMC11237030
Aquaporins (AQPs) are a family of water permeable channels expressed on the plasma membrane with AQP5 being the major channel expressed in several human tissues including salivary and lacrimal glands.
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PMC9429973
Subsequently, a total of 32,229 cells were identified and each of them was remotely classified and tagged by a panel of 3 different hematologists (randomly selected from the 6 who participated in the study) according to 6 different lineages: Myeloid, Erythroid, Monocytic, Lymphoid, Blasts and Plasma cells.
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PMC9429973
For cohort 1, AZA (75 mg/m) will be administered IV/subcutaneously on days 1-7 or 1-5, 8, and 9 of each cycle.
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PMC7136814
Rhabdomyosarcoma (RMS) and rhabdoid tumors (RT) are rare soft-tissue malignancies with the highest incidence in infants, children, and adolescents.
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PMC10968586
At higher concentrations, effects triggered by HT appear different and sometimes poorly reproducible.
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PMC11098378
Interestingly, the conserved catalytic cysteine, Cys-159 (C159), is nitrosylated in two of our three structural data sets, indicating that this cysteine is highly reactive and particularly susceptible to oxidation by agents such as nitric oxide.
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PMC11697065
Shared factors that were more abundant in high secretors include Foxo3, Fgfr1op2 and Spryd3 at D0, and Clcn4, Tmem104, Arhgap33 at D6 (Fig. 6A, left panels).
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PMC10502403
Thawed γδ-T cells were cultured in RPMI 1640 medium with 10% FCS for 4–6 h and then used in each experiment.
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PMC6835428
In an additional experiment, PTX at a dose of 15 mg/kg was IP administered alone or in combination with DFP-10825.
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PMC11787381
Statistical analysis was only performed for studies where each group size was at least n = 5.
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PMC10317042
Relative expression was calculated using the 2t method.
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PMC11461833
These findings were also validated by the qPCR results described above (Fig. 3F).
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PMC11222184
XL-888 has been shown to be effective in melanoma, liver, and advanced pancreatic/colorectal cancer .
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PMC11522251
p < 0.001, ** p < 0.01, * p < 0.05 and ns, cetuximab experimental group relative to control group Silencing HOXB8 inhibits the STAT3 pathway A The expression levels of HOXB8 mRNA were quantified through qRT-PCR 24 h following the introduction of three siRNAs into CACO2 and HCT116 cells. *
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PMC9429973
Aims: Here we report the initial efficacy and safety of this prospective, phase IIa, multicenter clinical trial with the chidamide based oral quadruplet regimen in patients with RRMM (ChiCTR2000035100).
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PMC11001582
We next investigated dysregulated pathways using quantitative proteomics.
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PMC10582049
The indolent group was composed of 9 patients and the aggressive group was composed of 7 patients (Fig. 1A).Figure 1Histological subtype and cellular composition of indolent and aggressive LUADs. (
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PMC7887261
Expression of the PI3K domain in ataxia-telangiectasia cells resulted in complemented radiosensitivity and reduced chromosomal breakage after irradiation, suggesting the PI3K domain contains many of the significant activity of ATM.
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PMC11092382
Compound kushen injection, a traditional Chinese herbal formula, has received approval from the National Medical Products Administration (NMPA) for its efficacy in managing malignant tumor-related pain and bleeding, as well as alleviating chemotherapy-induced adverse reactions.
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PMC10932641
The animal experiments in this study were approved by Laboratory Animal Ethical and Welfare Committee of North China University of Science and Technology Affiliated Hospital (No. SQ20230206) with oversight of the facility in which the studies were conducted, in compliance with the national guidelines for the care and u...
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PMC7723249
Polarized Caco-2 cells were infected apically or basolaterally with HAZV or CCHFV in the presence of supernatant from infected moDC with corresponding virus.
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PMC11116779
The assay directly measures the hydrogen peroxide (H2O2) level in the culture medium.
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PMC9429973
Six patients (8.4%) received allogeneic stem cell transplantation after Pola-BR treatment.
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PMC11064533
The lowest concentration inhibiting growth, i.e., MIC, was defined as OD600, where no growth was observed, mirroring the optical density of the negative control.
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PMC7823217
Although large scale manufacturing of bioprinted constructs is still in its infancy, manufacturers including Cellink and their partners, Prellis Biologics, are in the process of developing bioprinting equipment that can potentially address the requirements of industry and the clinic.
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PMC7802142
Previous studies focus on the facilitation of hair regrowth using EVs or exosomes.
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PMC11046454
Collectively, the Apt-CAR design was expected to open up new opportunities in T cell-based immunotherapy.
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PMC11683240
α1AT reduces intoxication of cells with PT by directly interacting with PT, thereby impeding its binding to cells.
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PMC6835762
PGA acylation with fatty acids has been intensively investigated both in terms of physical properties, self-assembling in NPs and for delivery of lipophilic and hydrophilic drugs .
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PMC11453018
Loss of LMNB1 expression has been a well-documented trigger of senescence, a cellular state often characterized by the accumulation of P15 protein .
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PMC10114490
A Representative fluorescence images of cells immunostained with antibodies against human albumin and α1-antitrypsin.
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PMC9429973
At the time of HSCT, only 3 pts (3%) were in complete remission (CR).
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PMC9164404
To further deliver CisPt(IV), HSA was selected to encapsulate this prodrug to form nanoparticles, namely AbPlatin (Scheme 1A).
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PMC9429973
FLT3+ (31%) received Midostaurin (day 8 to 21), CBF+ patients (3%) received GO.
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PMC6642070
Currently, the definition, epidemiology, diagnosis and management of SAMS are conflicting, which could be improved by further understanding of the pathophysiology of the symptoms.
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PMC11529598
DMEM with 20% FBS was added to the lower chamber.
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PMC11785489
As in the MART-1 experiments, we saw that each incremental gain in TCR-mem induced a greater fold change in activation (Figures 4D and S6B).
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PMC9261184
Other CO2” includes CO2 emissions from the GCU and from the auxiliary boiler.
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PMC11742290
Moreover, two CRC studies found no association between LGR5 protein expression and distant metastasis .
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PMC11545868
One notable difference compared to other flavonoids is that isoflavone families, such as prunetin or prunetin glycoside, are heavily studied in relatively hormone-sensitive tumors such as breast, ovarian, and prostate cancers .
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PMC11098378
We showed that 786–0 cells became sensitive to VSV-M51R infection after either overexpression of IpaH4 or knockdown of IpaH4 substrates, PSMC1 and SHOC2 (Fig 6).
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PMC11548041
Nanovesicle delivery vectors isolated from natural sources such as fat-free milk (MNVs) are an excellent delivery vehicle for therapeutic RNA molecules due to their low immunogenicity and the ability to be economically produced at a large scale .
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PMC11402217
Examinations of the lungs postmortem revealed extensive tumor formation in the control group, signifying advanced pulmonary metastasis.
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PMC10470467
Next, we subjected these 9 genes to multivariate Cox analysis, and 6 genes (JAK1, DNM1L, PYGB, CHMP7, GSDMD, and RIPK1) were identified as key genes.
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PMC10198699
If the research institution isolates the individual cells from the tissue sample and creates a cell line from the tissue sample, the default position would be that the research institution is the owner of the cell line.
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PMC11714165
The body weight of the mice was recorded every 3 days.
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PMC9429973
No significant differences were observed for rates of CR, 30- and 90-day mortality between patients receiving DR and non-DR IC.
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PMC10006224
We also generated A673 cells carrying a single complex and found that when only cohesin-STAG2 is present (STAG1 KO cells), NIPBL KD still reduced cohesin levels on chromatin (Fig. 3a).
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PMC11402217
Osteosarcoma (OS) is a malignant bone tumor predominantly affecting children and adolescents.
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PMC11473750
Homozygous TH-MYCN (TH-MYCN) breeder mice were treated for 2 weeks with cyclophosphamide to prevent tumour progression, then subjected to N-ethyl-N-nitrosourea (ENU) chemical mutagenesis of their germline at 6 weeks of age to induce random mutations in their sperm genome.
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PMC9429973
Twenty-seven patients (52.9%) were of standard cytogenetic risk and 11 patients (21.6%) of high cytogenetic risk according to IMWG criteria, data was missing for 13 patients (25.5%).
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PMC11786704
Serum liver and kidney function indicators: (A) Aspartate aminotransferase (AST), (B) Alanine aminotransferase (ALT), (C) Blood urea nitrogen (BUN) and (D) Creatinine (CRE). (
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PMC11583010
We next sought to confirm the selectivity of mAb 15A7.5 for tumors cells over keratinocytes with different methods.
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PMC11597167
Quercetin and oleuropein have been investigated for their potential to modulate MMP9 expression, which is involved in blood–brain barrier integrity and extracellular matrix remodeling.
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PMC11087055
As for axis-induction by other axis-inducing morphogens (Green, 2002), Vg1 may work dose-dependently for induction and patterning of the polonaise movements, and ectopic application may have over-ridden endogenous levels (Figure 3 and Figure 4).
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PMC9429973
Aims: We investigated addition of NEL and PEG into the hyperCVAD (HCVAD) regimen in adult pts with T-ALL/LBL.
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PMC11380329
Our study combined biochemical approaches and molecular biology techniques in order to elucidate the cellular and molecular effects of P against OVCAR4 cancer cells.
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PMC11389534
In pancreas, UFMylation components are overexpressed and protect pancreatic β cells from ER stress‐induced apoptosis.
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PMC9776316
Pathways that support cell survival and redox balance have also been shown to promote cisplatin resistance in multiple cancers .
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PMC10671321
For viral infection, MLCL ColQ −/− cells were infected 1 day after DM addition when myoblasts start fusing.
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PMC8633974
Tracking of the LNPs was achieved by including 80 μg of rhodamine DHPE (Invitrogen™ Lissamine™ Rhodamine B 1,2-Dihexadecanoyl-sn-Glycero-3 Phospho-ethanolamine, Triethylammonium Salt; DHPE) in the lipid film making process, followed by a LNP fluorescent tag.
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PMC11615101
Graph showing the Gene-Ontology enrichment process, function, and pathway based on the identified proteins. (
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PMC9429973
Aims: Authors compared thrombosis incidence, mortality and safety among cohorts of MPN patients with adequate on-treatment reactivity (AOTR) on ASA dosed once daily, twice daily and patients with HOTR.
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PMC11012313
BJAB or Ramos cell lines were plated at a concentration of 2 × 10 cells per well in the absence or presence of rapamycin (1 μM) using 6 well plates in complete RPMI at 37 °C, 5% CO2.
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PMC10919056
The results showed that risk score, age, and tumor stage were closely associated with survival time and clinical outcomes of ccRCC patients, and could serve as independent prognostic factors (Table 4).
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PMC10253553
Mitochondrial proteins (Mitochondrial Encoded Cytochrome C Oxidase, Succinate Dehydrogenase Complex Iron–Sulfur Subunit B, Cytochrome C Oxidase Subunit 4l1, and Succinate Dehydrogenase Complex Flavoprotein Subunit A) were significantly (p < 0.05) reduced, and proteins involved in glycolysis (Hexokinase 2, Pyruvate Kina...
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PMC9429973
The data supports the successful prophylactic treatment of elderly patients and the need to continue to collect data in this population of patients with this rare bleeding disorder.
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PMC11095939
n = 5 mice/group; n.s.,
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