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PMC7338939
Equation (2) shows that optimizing f(t) leads to minimizing the tumor size and the injection dose of DAPT, simultaneously.
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PMC11478724
The morphology of A549 cell lines was imaged after 72 h of exposure to PMX in comparison with the control group, using microscopy with 400X magnification (b) There has been a significant increase in LDH activity observed after PMX treatment.
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PMC9429973
Multiparameter flow cytometry of unseparated full blood was used to enumerate major immune cell subsets.
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PMC9429973
The leukemia-associated variant (SF3B1) was observed in the cfDNA sample (0,0003) at the first follow-up sample but was negative at the following TPs.
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PMC7602170
Thus, the high influence of eIFs on protein translation is of utmost interest in targeted cancer therapies.
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PMC11782780
Moreover, some investigations reported the role of glycolysis in cancer cell stemness and its molecular modulatory mechanisms.
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PMC10237474
Our study shows that Expi293F and Expi293F GnTI stable pools generated by the PB system are highly suitable for producing recombinant proteins, including protein complexes, for clipping remediation and structural biology, at a low cost and fast turnaround time.
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PMC10547921
The R3 region can tolerate a variety of substituents, and the ethyl substituent compound 108 is obtained by replacing a more rigid unsubstituted phenyl ring, which has a similar effect on A2780 and CORL23 cell lines to compound 107.
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PMC10571053
As the A673 cell line was reported to be sensitive to FINs and did not express P-gp or ABCG2, we transfected this cell line with either empty vector (A673 EV) or vectors containing the genes encoding human P-gp (A673 B1) or ABCG2 (A673 G2).
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PMC11790599
This could be due to methuosis is not cross-resistant to apoptosis, as many other non-apoptotic forms of cell death.
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PMC11502443
The Operational model of agonism was employed to consider the contribution of both potency and Emax to differences in signaling.
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PMC4816271
Codon-opimization used an in-house algorithm (written by MP, available on request): the algorithm strove to keep GC content at 70% and eliminate cryptic splicing, harpins, literal repeats and any possible cis-acting sequences.
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PMC6312945
UV spectrophotometer (Bio-Rad Laboratories, Inc., Hercules, CA, USA) was used to analyze the concentration and purity of RNA extracted, and 3% agarose gel electrophoresis was used to analyze RNA integrity.
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PMC11473750
We show that RNF121 is a transcriptional target for MYCN, which in turn binds the MYCN protein in a “protective” manner to increase MYCN stability, possibly in the Golgi.
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PMC9429973
Intervention Esomeprazole 40mg twice daily and placebo for 12 months in a cross-over design.
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PMC10317042
Antibody-bound DNA was purified using DNA purification buffers and spin columns (14209S; Cell Signaling Technology) and amplified for use as templates in CUT&RUN–qRT-PCR or to construct libraries in CUT&RUN-sequencing (CUT&RUN-seq).
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PMC8540611
Complexes of FAM-labeled siRNA and AuNP were added to the cells.
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PMC10713411
Although apoptosis has been recognized as a key biological process for tumor suppression and several drugs targeting apoptosis have gained some clinical and research momentum, other modes of PCD are as important as apoptosis for the study of potential targets for tumor therapy because of its distinct molecular mechanis...
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PMC8922418
We also successfully targeted CCR5 in primary CD4 T cells and CD45 HSCs with AAV6-sgRNA/SaCas9 and demonstrated that CCR5 CD45 HSCs differentiated normally and showed HIV-1 resistance in NSG mice (Wang et al., 2017).
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PMC8097906
Cell viability measurement via MTS-assay after treatment with VSM extract (1, 10, 25, 50 and 100 μg/ml) of the primary non-tumorigenic control cells: a human mesenchymal stem cells (hMSCs) and b human fibroblasts (NHDF), as well as of the RMA cell line: c HA-OH1.
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PMC9545714
The Qiagen RNeasy kit for RNA extraction was purchased from Qiagen (Germantown)S. A 0.1% (w/v) stock solution of dried tomato extract in THF was prepared for use in the gene expression experiment.
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PMC9429973
These results support a multidisciplinary and collaborative approach to SCD care in order to optimize pt outcomes, where each HCP speciality and care setting fulfills distinct but vital aspects of pts’ needs.
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PMC9386809
More such applications of the new Cl2Zr–BPC complex 2 and other main group metal complexes are currently under investigation and will be reported in due course.
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PMC10820104
These two enzymes are involved in the prenylation and reverse prenylation cascades taking place at different positions of the indole DKP core structure of echinulin and neoechinulin congeners, resulting in the formation of mono-, di-, tri-, and tetraprenylated derivatives .
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PMC9429973
SIRT1-SIRT7 expression was evaluated by Droplet Digital PCR method while the miRNAs level was evaluated by Real Time PCR method.
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PMC9370419
The drug library consisted of a collection of 1403 Food and Drug Administration (FDA)-approved drugs and was purchased from the TOP SCIENCE company, Shanghai, China.
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PMC11082662
This can be achieved by gene knockout, overexpression, or inhibition of SMPDL3B expression to observe changes in ovarian cancer cell proliferation and validate its effectiveness as a drug target.
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PMC11740399
The in vitro and in vivo study demonstrated that GPR120 increases the expression of Acetyl-CoA carboxylase, sterol regulatory element-binding transcription factor 1, sterol regulatory element-binding transcription factor 2, and FASN and induces the chemical drugs resistance to breast cancer cells .
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PMC8345486
A parallel increase in late apoptosis cells was disturbed in “+2 cells”, indicating inhibition of this process in cells cultured with long-term treatment of compound 2 (Figure 9A).
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PMC3035438
We first confirmed that the chimeric CX13 cells expressed membrane-bound IgM, which were detectable at levels comparable to the parental wild-type (WT) cells by flow-cytometry using a fluorescein-conjugated anti-chicken IgM antibody (Figure 2A).
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PMC11297139
The trimmed paired-end sequences were mapped to the human reference genome hg38 using bowtie 2 with parameters “—very-sensitive –X 1000 –dovetail”.
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PMC11795610
In skin, TRPV4 highly expresses in keratinocytes and immune cells, its dysfunction is related to impaired epidermal barrier function, itching and inflammation.
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PMC11015054
It has been demonstrated that abnormal modifications to m6A are associated with HCC progression.
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PMC11155445
Alizada and Arslan synthesized a novel derivative of acyl thiourea 1-(4-chloro-benzoyl)-3-(2-trifluoromethyl-phenyl)thiourea (111) by reacting 4-chlorobenzoylchloride with KSCN followed by reaction with 2-(trifluoromethyl)aniline in dry acetone.
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PMC9429973
Clonogenic capacity was evaluated by clonogenic assays.
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PMC11301095
The constellation of the patient’s clinical presentation, including symptoms, physical findings, supportive diagnostic tests, epidemiological history, and pathogen identification, culminated in a definitive diagnosis of PAM in a pediatric patient.
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PMC7723249
Serial (1:10) dilution of the viruses in DMEM with 2%FBS, were used to infect Vero Cells.
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PMC11592008
The FACS analysis was performed using a BD Accuri C6 flow cytometer (BD Biosciences, Franklin Lakes, NJ, USA).
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PMC11612794
Similar to the human case, it is possible that the aa 1–21 of chicken CENP-C might also cause a steric clash with the basic motif of Dsn1.
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PMC11291697
However, unlike the clinical picture of the first reported individual , our proband shows microcephaly and symptomatic epileptic syndrome, broadening the phenotypic spectrum of the novel GTDC1-related condition.
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PMC9100622
This study was performed in accordance with the recommendations of the European Community (2010/63/UE) for the care and use of laboratory animals.
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PMC11306331
Significance was determined using the Mann–Whitney U test: n.s.:
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PMC9621239
Studies on the differences in the characteristics of HBV QS across PreS and core promoter regions between tumour and non-tumour tissues are not scarce.
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PMC11572213
Therefore, cancer cells adapt their metabolism to their environment for survival and proliferation.
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PMC10237474
Insect cell lines such as SF9 and Hi5 are popular expression hosts to generate glycosylated soluble or membrane proteins for structure determination in addition to HEK293S GnTI cell lines.
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PMC11657695
G Relative cell number in A-673 (N = 5) and SK-ES-1 (N = 4) cell lines, according to KCNA2 expression.
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PMC11727306
It is shown that abrin toxin induces signal activation that amplifies superantigen activity and boosts, in a dose-dependent manner, cytokine secretion in stimulated T-cells.
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PMC11495567
After 48 h exposure to 5 μM of the PCAIs, NSL-YHJ-2-46, the MAPK proteins BRAF, MEK1/2, ERK1/2, and p90RSK were activated through phosphorylation by 90, 190, 150 and 120%, respectively.
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PMC9429973
Finally, 95% (N=77) reported the education will improve their performance and 89% that it would improve patient outcomes.
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PMC10048572
Similarly, 21 primary clones of the WIL2-S line were analyzed, one clone was selected for further cultivation and 350 of its subclones were analyzed by STR-PCR .
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PMC9429973
The total duration of the study treatment period is 5 years (Figure).
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PMC9429973
Blood, 2009; Platelets, 2021) However, large-scale clinical studies on mortality and associated risk factors are still lacking.
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PMC11763126
The mixture was ultrafiltered using a 10 kD cutoff filter, and the filtrate was collected.
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PMC11805741
The extract induced apoptosis, as evidenced by significantly increased BAX/BCL-2 gene expression ratios at 600 and 1200 µg (p < 0.05).
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PMC7039683
AP, active promoter; WP, weak promoter; PP, poised promoter; AE, active enhancer; WE, weak enhancer; TT, transcriptional transition; WT, weakly transcribed; Ins, insulator; PR, polycomb-repressed. (
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PMC11711871
The resting tension (RT) was determined as the lowest tension achieved by each vascular ring during the entire experiment after the stretch/equilibration/wash steps.
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PMC11599565
Bar graphs represent densitometric analyses of western blots performed to measure protein expression following drug exposure.
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PMC11352877
Migration efficiency was calculated using ImageJ. The total RNA was obtained from a cell suspension using a modified manufacturer’s protocol using an RNeasy mini kit (Qiagen; Hilden, Germany).
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PMC11585565
Human embryonic kidney 293 (HEK293) cells obtained from the American Type Culture Collection (ATCC, VA, USA) were used in this study.
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PMC8873393
Furthermore, inhibition of G2/M transition was also detected during the time course examined after DNA repair (profiles in red in Fig. 1G).
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PMC11486946
Auto Imaging System (ZIDO Corp., Japan), including an autofocus device and AI-aided cell searching applications, was equipped to automatically obtain in-focus images of the cells with a suitable density of fluorescent spots for single-molecule analysis.
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PMC11593713
However, in high-risk groups, they are associated with a range of respiratory complications, including bronchiolitis and pneumonia .
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PMC11721277
The increased hepatic uptake is an unexpected feature for an HYNIC-containing chlorin.
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PMC11633763
Additionally, USP22‐knockdown osteosarcoma cells were treated with cycloheximide.
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PMC11506670
No.4520; Corning, Merck KGaA, Darmstadt, Germany), at a density of 3000 cells per well in triplicate.
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PMC11731614
Workflow schematic depicting EV proteomic analysis.
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PMC9398137
Importantly, conditional gene knockout studies demonstrated that MCL1 is essential for survival of several normal, non-transformed cell types, including hematopoietic stem cells or cardiomyocytes, raising the question of tolerability when targeting MCL1 (29–31).
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PMC11001582
Fig. 5(GR)400 and (PR)400 knock-in mouse spinal cord has increased ECM protein levels.a, GO term enrichment analysis from significantly upregulated (blue) proteins in the lumbar spinal cord of 12-month-old (GR)400 (left panel) or (PR)400 (center panel) mice and C9orf72 patient iPS cell-derived motor neurons (right pane...
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PMC8524093
Similar to what is observed in non-pregnant animals, viremia level peaked at 2–3 dpi, and appearance of fever and changes in blood cell counts correlated with peak viremia.
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PMC7171147
Indeed, we observed an increased expression of FASN in ES2 cells co-cultured with COL11A1-expressing CAFs (Fig. 4A) or supplemented with recombinant COL11A1 (Fig. S1D) or cultured in COL11A1-coated plates (Fig. 4b–f), and in OVCAR3 and A2780 cells cultured in COL11A1-coated plates (Fig. S5C–F).
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PMC10198699
In the next two paragraphs, I address two common arguments against the conclusions reached above.
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PMC11742670
Table 5Vidarabine IC50 comparison between the DL model prediction and pharmacological studies.
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PMC10938336
To deepen the understanding of these effects, molecular docking and network pharmacology were employed.
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PMC7759933
The spheroids with an initial density of 3000 cells/spheroid (Figure S1A) grew time-dependently from the first day of seeding.
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PMC9429973
Patients with recurrent genetic abnormalities did not reach median survival whereas median survival of patients with AML-MRC, tAML, and NOS was 11, 12, and 14 month (p < 0.0005).
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PMC4485786
In the rapidly growing FcIL-7-control tumors 50% of the sarcoma cells stained positive for PCNA or Ki67, showing that most of the cells were proliferating (Fig. 5A, B).
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PMC9429973
Aims: We aim to identify DICER1 and DROSHA variants in hematological malignancies that lead to the protein function alteration based on bioinformatics analysis.
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PMC9918897
Measurements were carried out at λ = 734 nm with Trolox as calibrating substance (calibration range: 0–1250 μmol Trolox/liter).
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PMC10874773
simonsiiYin, Wang, Wang, & Kong, 201238Veranisatin DI.
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PMC10222971
In this case, the number of viable cells increased to 54.8% in comparison to the previous experiment with a 16.8% of viable cells at 100 µM. Therefore, the drastic conditions and high cell death decreased.
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PMC11679033
When we look at the results shown in Figure 7 and Table 3 together, the following can be concluded: treatment with single CIT caused a significant lowering of CBPI and RI compared to the negative/solvent controls, owing to increased proportions of M1 cells.
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PMC11279598
In these studies, Actin (dil 1:1000, cat# PA5-58528, Invitrogen/ThermoFisher Scientific, Carlsbad, CA, USA) and GAPDH (cat# 12004167, BIORAD, Hercules, CA, USA) were used as a loading control.
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PMC11742047
SIMCA 17 was used to perform a supervised OPLS-DA model, and excellent quality parameters were obtained for the explained variance (RX = 0.92; RY = 0.998; RX = 0.91; RY = 1) and predicted variance (Q = 0.992; Q = 0.993) of the LC–MS ESI (+) and LC–MS ESI (−) data (Figure Supporting information 2).
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PMC10154881
Because rMV‐SLAMblind infects human cancer cells through NECTIN4, we searched by western blotting for mouse cancer cell lines that expressed NECTIN4.
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PMC7812570
The disruptive effects of GPI-m36.4 on HIV-1 Env processing and viral infectivity were further characterized, verifying a multifaceted mode of antiviral action.
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PMC11055443
In this study, V. cholerae ATCC14035 was used.
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PMC10890307
Thus, acidosis induced an arrest in G0/G1 but, in combination with the hypoxia, the S-phase diminished, and cell death of A427 cells increased (Figure 5B).
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PMC11754094
d, Z-score comparison of the difference in large-deletion frequency between negative control (non-targeting) cells and those with the indicated repair pathway compromised.
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PMC11551844
Further biological activity of JDE, AuNPs-JDE, JDH, AuNPs-JDH and AuNPs-control were conducted using HepG2 (human hepatocellular carcinoma) and HeLa (human cervical adenocarcinoma).
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PMC4685407
The CRISPR-Cas9 system induces double-strand breaks (DSBs) via guide RNA and Cas9, which increases the efficiency of homologous recombination .
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PMC9596868
Secondary antibodies, anti-mouse IgG-HRP (Cat.
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PMC9532503
The percentage afucosylation was inversely correlated with osmolality, irrespective of the compounds used to adjust osmolality (ionic vs. non-ionic or substrate vs. non-substrate).
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PMC6934009
In the USA alone, more than 15 million patients with lung cancer were detected (1).
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PMC11746948
Statistical analysis: two-way ANOVA with Tukey’s test for (q); one-way ANOVA with Tukey’s test for (e, j, l, n).
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PMC9429973
The erythroid maturation is megaloblastoid and show binucleation in 10% to 15% of the erythroid cells.
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PMC9429973
T-cell responses were assessed six months after the first dose using an ELISA-based interferon-gamma release assay.
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PMC11767793
Although nanotoxicology is a mature field, it is not realistic to expect full epidemiological and ecosystem data for every MNM product given the multiple specific hazard factors, such as the particle size, shape, crystallographic structure, and surface charge.
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PMC11519567
F Representative image of EdU assay in synovial sarcoma cell line SW982 with the lentiviral expression of EGFP, wild-type and AR mutant SS18-SSX1.
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PMC9429973
Estimated cumulative incidence of relapse and non-relapse mortality 2y after pos MRD was 60% and 7% respectively (see figure).
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PMC11725127
These data collectively suggest that USP2 is a direct interacting protein of GA.
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