OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10454535	To assess the possibility of oxidative stress induced by PIN/BTZ, we sought to observe whether NAC treatment rescues the cells and whether BSO increases cytotoxic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	First-strand cDNA was synthesized from 1–2 µg of total RNA using MMLV reverse transcriptase according to the manufacturer’s instructions (Evrogene, Russia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11512230	Apart from that, another important aspect of adsorption is the specificity and selectivity of a delivery system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apart", "from", "that", ",", "another"...
PMC11607321	Regarding conditional features, although their average feature importance was modest, certain key features, such as TP53 mutation, growth rate, and tissue of hematopoietic and lymphoid origin emerged as highly significant, even when compared with other omic datasets (Fig. 4a, Supplementary Data 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	Previously we showed that crizotinib (HGF/c-Met-inhibitor) was shown to overcome platinum chemoresistance mediated by tumor activated HS-5 (TA HS-5) conditioned medium (CM) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC11786600	However, portable electrospinning is limited by the choice of materials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "portable", "electrospinning", "is", "limited", "by", "the", "choice", ...
PMC11604768	Orange and gray projection lines indicate the positive and negative directions of the treatment projection, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Orange", "and", "gray", "projection", "lines", ...
PMC9952933	Thus, the aim of this study is to treat osteosarcoma cells, Ewing’s sarcoma cells, and primary human osteoblasts with CAP and to compare the in vitro effects with respect to ROS accumulation, cell viability, and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To compare efficacy and safety of 10-day DEC followed by allografting to IC followed by allografting in older fit AML pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...
PMC11742670	such as the employment of an alternative SMILES notation for decalin could be C1CCCC2CCCCC12, whereby both ring-closing bonds involve the last carbon atom labeled as ‘1’ and ‘2’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	f Reaction pathways of DNP1-based computation in target cell microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "Reaction", "pathways", "of", "DNP1-based", "computation", "in", "target", "cell", "microenv...
PMC4395774	The correction seen was partial but nevertheless significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "correction", "seen", "was", "partial", "but", "nevertheless", "significant", "." ] } ]
PMC9429973	The most recent TKI was discontinued for resistance in 14 (32%) and intolerance in 30 (68%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most"...
PMC11766309	These results indicate that YKT6 may play a vital role in the tumor initiation stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate", "that", "YKT6", "may", "play...
PMC11794847	Furthermore, our data suggest that HVEM is pivotal in T cell metabolic reprogramming, transitioning from oxidative phosphorylation to aerobic glycolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ...
PMC11541241	In addition, these situations may suggest rewriting the pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "these", "situations", "may", "suggest", "rewriting", "the", "pathway", ...
PMC11742047	Data in the column bar represent the mean ± SD of three different experiments done in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "in", "the", "column", "bar", "repre...
PMC11687167	In the development of these autoimmune diseases, such as SLE, RA, and psoriasis, PCSK9 levels are strongly correlated with disease activity and severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11617590	Each experiment was performed at least three times independently. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "performed", "at", "least", "three", "times", "independently", ".", ...
PMC9429973	The activities of INHERENT are currently divided into five working groups, as follows: clinical, genotyping, data management and analysis, ethics, and knowledge translation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10606998	The dose 4 Gy was chosen on the basis that the cells should receive sufficient stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dose", "4", "Gy", "was", "chosen", "on", ...
PMC9429973	No relapses were observed in G3AFL group after 6 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "relapses", "were", "observed", "in", "G3AFL", "group", "after", "6", "years", "." ...
PMC11502327	In the early stages, even though the conventional treatment regimen is effective, the damage caused by the neurological and renal toxicity of chemotherapy drugs is difficult to estimate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median follow-up time of 37 patients after treatment was 890 days (104-1062).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "follow-up", "time", "of", ...
PMC9429973	Among unfit pts, those receiving IC had significantly longer overall survival compared with pts receiving a VEN-based regimen (median overall survival, 14 vs 6 months, respectively; HR, 0.51 [95% CI, 0.27–0.98]; P = 0.042; Figure).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	In further experiments, Fratoni et al. tested derivatives 16, 18, and 19 against 16 human cancer cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "further", "...
PMC8750422	Collectively, our results indicate that eNOS is a key mediator for GPR87 in the regulation of metastatic properties through the AKT-NO signaling pathway in lung adenocarcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11589157	We assembled over 16 Mb of Y-sequence, the second longest among reported gibbon genome data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "assembled", "over", "16", "Mb", "of", "Y-s...
PMC11679033	SH-SY5Y cells were grown in Dulbecco’s Modified Eagle’s Medium F12 containing 15% (v/v) fetal bovine serum (FBS), 2 mM glutamine, 1% (v/v) penicillin/streptomycin (PenStrep solution), and 1% (v/v) non-essential amino acids (NEAA solution).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: In this study with intensively treated newly diagnosed AML, we noticed a similar incidence of thrombosis to that previously reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10968586	ROS-mediated damage at least in part accounts for chemotherapy-dependent toxicity detected at the tissue level on non-cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROS-mediated", "damage", "at", "least", ...
PMC11753949	Such greater thickness is most likely due to actin crosslinking by synaptopodin not in contact with the ER.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "greater", "thickness", "is", "...
PMC8711270	In second generation AdV vectors, additional genes required for viral replication have been inactivated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "second", "generation", "AdV", "vectors", ",", "additi...
PMC9429973	Multivariable analyses including IGLV3-21, disease stage, and IGHV gene SHM status or epigenetic subtypes confirmed the independent prognostic value of IGLV3-21 on TTFT (p<0.005).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	NTA showed that the size of ReN-NV was < 200 nm mainly with peaks at 129 and 170 nm (Fig. 1b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NTA", ...
PMC6364197	Flow cytometry analysis was performed to analyze whether the cell phenotype changes after cultivation in scaffold for one week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analysis", "...
PMC11640555	This finding reasserts the efficacy of CK2 inhibitor CX-4945 as an anti-cancer and inflammatory agent against GBM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "reasserts", "the", "efficacy",...
PMC11747467	P-value < 0.05; , P-value < 0.01; , P-value < 0.001; ***, P-value < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Thus, bioprinted tumor models developed using organoids from patient-derived tumor cells of pleural effusion fluid exhibit in-vivo-like anatomy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "bioprinted", "tumor"...
PMC11449273	In the cytoplasm, plakoglobin reduces β-catenin level and its translocation into the nucleus/oncogenic activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "cytoplasm", ",", "plakoglobin", "reduces", "β-...
PMC9100622	Altogether, the data show that statins, which are off-patent, well-tolerated, and inexpensive compounds, should be strongly considered in the therapeutic arsenal against this deadly childhood disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	Among them, immune checkpoint blockade therapy represented by PD-1/PD-L1 inhibitors (nivolumab) and CTLA-4 inhibitors (ipilimumab) has shown encouraging therapeutic effects in the treatment of various malignancies, such as non-small cell lung cancer (NSCLC) and melanoma, etc. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11279397	However, previous studies have primarily focused on modeling virus infection in vitro using cell lines, with only a limited number of recent studies validating these findings through in vivo experiments in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	The number of NeuN positive pyramidal cells in the CA1 area was measured as well as AT100 into NeuN(+) pyramidal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "numbe...
PMC11764090	Finding the upstream temperature signal sensor of the plant cold-signaling pathway is a fundamental problem in future research because these receptors are very likely to play a switching function for the whole cold-signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among vaccinated patients who suffered a severe/critical infection, 52% did not have vaccine seroconversion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "vaccinated", "patients", "who", "suffered", "...
PMC11352311	Fluorescence images were captured using a fluorescence microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "images", "were", "captured", "using", "a", "fluorescence", "microscope", "." ] } ]
PMC11544122	Loss of endogenous surface CXCR4 in HeLa cells was measured by flow cytometry as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Loss", "of", "endogenous", "surface", "CXCR4", ...
PMC11129910	In six patients (46.15%) who underwent axillary nodal dissection, lymph node metastases were present in two cases, and one of them had extracapsular extension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	C-phycocyanin consists of two subunits, α and β, which are found in equal quantities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C-phycocyanin", "consists", "of", "two", "subunits", "...
PMC5363531	Compared with untreated, dasatinib treatment abolished cell migration capability to heal the scrape after 24 hours in both REN and MPP89 cell lines (left and middle panels), and after 8 hours in MSTO (right panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "...
PMC11593084	We have reported CasMabs against PDPN (LpMab-2 and LpMab-23 ), which were obtained by immunization of LN229/PDPN with mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "rep...
PMC7334607	Right: Two waterfall plots representing the samples ranked by their responses to the two drugs, vorinostat (SAHA, top) and SP-2509 (SP, bottom).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670954	The metabolites produced by the microbiota are vital for maintaining health .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "metabolites", "produced", "by", "the", "microbiota", "are", "vital", "for", "m...
PMC10808409	Transmission electron microscopy revealed spherical shaped globules with smooth surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transmission", "electron", "microscopy", "revealed", "spherical", "shaped", "globules", "with", "smoot...
PMC9436459	On the basis of the position of dehydroprenyl unit, type D MDAAs are divided into two subgroups: type D-I (the diene moiety on ring A) and type D-II (the diene moiety on ring B), as illustrated by the structures of 92–104 and 105–113, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422150	Sensory examination of the bilateral hind paw region of SCI mice was done by examining the paw withdrawal reflex after the application of a series of forces using TACTILE TEST (AESTHESIO) Semmes–Weinstein von Frey anesthesiometer (Muromachi Co. Ltd, Japan) (Godfrey et al., 2018; Ranade et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991	It may also be that in the lungs, the ability of TRPV4 to sense mechanical changes in the cell microenvironment is essential for the morphogenesis of all the tissue compartments within the lungs, including epithelium, smooth muscle layer and the vascular compartment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	Raw files were searched using a local copy of PEAKS with the following parameters: Database: Swiss-Prot mouse oval-chick for murine immunopeptidome or Swiss-Prot human for the myeloma immunopeptidome; fixed modification: none; variable modifications: oxidation (M), acetyl (N-terminus), carbamidomethyl (C); mass values:...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Image showing the OVCAR5 and MRC-5 cells at 8 day of coculture. (	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "showing", "the", "OVCAR5", "and", "MRC-5", "cells", ...
PMC5600151	PLL dendrimers of low generations have fewer primary amines, which was not optimal for complexing large nucleic acid molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLL", "dendrimers", "of", ...
PMC9429973	Besides, 7 patients were diagnosed with double-hit lymphoma and 4 patients were relapsed after previous CD19 CAR-T cell therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "7", "p...
PMC10747160	While these values are not as potent as the inhibitory capabilities of Griffithsin against other viruses, these values are largely within the range of values expected for SARS-CoV-2 pseudoviral inhibition (Table S1) and are still considered to be potent enough for Griffithsin to be potentially used as a viable agent to...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11737091	GO terms and KEGG pathways of genes similar to DBF4. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "terms", "and", "KEGG", "pathways", "of", "genes", "similar", "to", "DBF4", ...
PMC9878562	While VAL-ko alone did not migrate to the axillary lymph node, in the presence of VAL-wt or DOHH2 the CFP VAL-ko could readily be detected ( Figure 3B ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	Researches showed that HLA-A2 with the immunodominant HBcAg18–27 epitope (HLA-A2.1- restricted CTL epitope) binding peptides of vaccine or of HBcAg initiated specific respond of T cell and resolved cute HBV infection .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Our study was the first one using scRNA-seq to disclose the tumor heterogeneity and immune microenvironment of RS and aCLL/SLL in single-cell dimension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	A supervised-machine-learning classifier, gapped k-mer support vector machine (gkmSVM) was used to generate a 10-fold larger set of random genomic 400 bp sequences in the danRer7 reference genome, based on matching of GC and repeat fraction of the positive training set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486	The surface expression of Face-1 in the cell line was achieved by supplementing either with mouse or human B2m. The second is the R1 cell line of a somatic cell variant of the C3H (H-2) thymoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11243198	These interacting residues are positioned near the GLI1-ZF DNA binding site (Figure 6D) and are also conserved between GLI1 and GLI2 proteins (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11011837	Moreover, within the context of T-ALL, cases labeled as ‘unclassified’ due to the absence of cytogenetic markers could benefit from multiomics approaches, such as metabolomics and lipidomics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8753818	After 28 h , cells were fixed in 70% ethanol , and DNA was stained using PI in the presence of DNase-free RNase A (40 mg/mL) for 30 min at 37 °C in the dark circumstance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	In contrast, SLAMF2/CD48 binds to SLAMF4/CD244 and vice versa.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "SLAMF2/CD48", "binds", "to", "SLAMF4/CD244", "and", "vice", "versa", ...
PMC11687167	In the future, more researches and refinements are needed before these new approaches could be translated into clinical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "future", ...
PMC9429973	PD activity of IBER was not attenuated by prior refractoriness to immunomodulatory drugs (IMiD agents) or anti-CD38 therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PD", "activity", "of", ...
PMC9429973	The safety profile was manageable.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "safety", "profile", "was", "manageable", "." ] } ]
PMC11740573	It also reduces the need for excessive activation of pro-inflammatory defense mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "reduces", "the", "need", "for", "excessive", "activation", "of", ...
PMC11718809	PYCR1 promotes intracellular amino acid metabolism during lactation and is associated with L-proline synthesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PYCR1", "promotes", "intracellular", "amino", "acid", "metabolism", "d...
PMC10204952	This “inside-out signaling” activates and/or promotes vast biological functions such as cell proliferation and survival, angiogenesis and T-cell migration [6–9].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11604768	FBS was purchased from Omega Scientific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FBS", "was", "purchased", "from", "Omega", "Scientific", "." ] } ]
PMC11457557	These ncRNAs might be used as biomarkers to determine possible targets for DKD prevention and therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "ncRNAs", "might", "be", "used", "as", "...
PMC9429973	The improved OS emained significant (HR 0.043, 95% CI 0.003-0.63, p=0.021) in multivariate analysis when adjusted for sex, age, hypereosinophilia in the blood, PDGFRA/B fusion status, complex cytogenetics at diagnosis, the blastic-phase at diagnosis, and alloHSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	The EVs tested resulted in increased expression levels of α-SMA, FAP, and Galectin proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EVs", "tested", "resulted", "in", "increased", ...
PMC11711345	The compounds showed high GI absorption, except for p-cymene according to the SwissADME server, suggesting that it is difficult for this compound to be absorbed across the intestine after oral intake.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	Further studies on the temporal pattern of DBP phosphorylation at each site and those on the phospho-degron recognized by TRAF7 will unveil the mechanism underlying the time-of-the-day-dependent regulation of DBP protein level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	Nevertheless, it is apparent that additional efforts are required to enhance the effectiveness of this therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "it", "is", "apparent", ...
PMC11531735	These observations were further corroborated by analysis of brain tissue from the treatment group compared to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "observations", "were", "further", "corro...
PMC10040136	Additionally, MSC were observed to secrete TGF-β2, consequently activating the PI3K-AKT pathway and augmenting GIST resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "MSC", "were", "ob...
PMC10362265	Contrary to these two complexes, the heterodimers showed almost rigid backbones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Contrary", "to", "these", "two", "complexes", ",", "the", "heterodimers", "showe...
PMC11583010	The injection sites and skin were observed for local reactions and evidence of toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "injection", "sites", "and", "skin", "were", "observed", "...
PMC11087766	For protein expression, LB was supplemented with 15 μg/mL gentamicin and 0.1% arabinose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "protein", "expression", ",", "LB", "was", "supplemen...
PMC9429973	Pts randomized to KRd received carfilzomib 36 mg/m on days (D) 1,2,8,9,15,16 for 4 cycles (C) then D1,2,15,16 starting C5; R 25 mg D1-21, and dexamethasone 20 mg D1,8,15,22 in 28-day cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012012	Elotuzumab, a therapeutic anti-SLAMF7/CD319 antibody, induced dose-dependent ADCC activity toward BC2 target cells, using PBMCs as effector cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elotuzumab", "...
PMC9429973	All the patients had previously been treated with schedule containing bortezomib and IMIDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "patients", "had", "previously", "been", "treated", "with", ...
PMC11791478	Both ADCs use the microtubule polymerization inhibitor monomethyl auristatin E (MMAE) as the payload (18, 20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "ADCs", "u...
PMC11585994	In conclusion, G5-sgc8-siBCL11B nanoparticles effectively reduce T-ALL tumor burden and prolong survival in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "G5-sgc8-siBCL11B", "nanoparticles", "eff...
PMC11451940	Complexes 1 and 5 increased the number of cells arrested in the G2/M phase, while 7 arrested the majority of the A2780 cells in the G0/G1 phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9275501	NDCDS can change the original pharmacokinetic characteristics of drugs, so as to ensure that the combined drugs enter tumor cells with a constant proportion, which is conducive to the synergy between drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In particular, we observed an enrichment of specific CD8+ T cell subsets in the CR group, while certain CD4+ T cell subsets, such as regulatory T cells were enriched in REL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We recently identified Endomucin (EMCN) as a novel HSC marker, a transmembrane protein conserved in mouse and human throughout development, but not in lineage-committed haematopoietic progenitor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10454535

To assess the possibility of oxidative stress induced by PIN/BTZ, we sought to observe whether NAC treatment rescues the cells and whether BSO increases cytotoxic effects.

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PMC8389560

First-strand cDNA was synthesized from 1–2 µg of total RNA using MMLV reverse transcriptase according to the manufacturer’s instructions (Evrogene, Russia).

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PMC11512230

Apart from that, another important aspect of adsorption is the specificity and selectivity of a delivery system.

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PMC11607321

Regarding conditional features, although their average feature importance was modest, certain key features, such as TP53 mutation, growth rate, and tissue of hematopoietic and lymphoid origin emerged as highly significant, even when compared with other omic datasets (Fig. 4a, Supplementary Data 9).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10955424

Previously we showed that crizotinib (HGF/c-Met-inhibitor) was shown to overcome platinum chemoresistance mediated by tumor activated HS-5 (TA HS-5) conditioned medium (CM) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "...

PMC11786600

However, portable electrospinning is limited by the choice of materials.

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PMC11604768

Orange and gray projection lines indicate the positive and negative directions of the treatment projection, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Orange", "and", "gray", "projection", "lines", ...

PMC9952933

Thus, the aim of this study is to treat osteosarcoma cells, Ewing’s sarcoma cells, and primary human osteoblasts with CAP and to compare the in vitro effects with respect to ROS accumulation, cell viability, and apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Aims: To compare efficacy and safety of 10-day DEC followed by allografting to IC followed by allografting in older fit AML pts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...

PMC11742670

such as the employment of an alternative SMILES notation for decalin could be C1CCCC2CCCCC12, whereby both ring-closing bonds involve the last carbon atom labeled as ‘1’ and ‘2’.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754784

f Reaction pathways of DNP1-based computation in target cell microenvironment.

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PMC4395774

The correction seen was partial but nevertheless significant.

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PMC9429973

The most recent TKI was discontinued for resistance in 14 (32%) and intolerance in 30 (68%).

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PMC11766309

These results indicate that YKT6 may play a vital role in the tumor initiation stage.

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PMC11794847

Furthermore, our data suggest that HVEM is pivotal in T cell metabolic reprogramming, transitioning from oxidative phosphorylation to aerobic glycolysis.

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PMC11541241

In addition, these situations may suggest rewriting the pathway.

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PMC11742047

Data in the column bar represent the mean ± SD of three different experiments done in triplicate.

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PMC11687167

In the development of these autoimmune diseases, such as SLE, RA, and psoriasis, PCSK9 levels are strongly correlated with disease activity and severity.

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PMC11617590

Each experiment was performed at least three times independently. (

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PMC9429973

The activities of INHERENT are currently divided into five working groups, as follows: clinical, genotyping, data management and analysis, ethics, and knowledge translation.

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PMC10606998

The dose 4 Gy was chosen on the basis that the cells should receive sufficient stress.

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PMC9429973

No relapses were observed in G3AFL group after 6 years.

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PMC11502327

In the early stages, even though the conventional treatment regimen is effective, the damage caused by the neurological and renal toxicity of chemotherapy drugs is difficult to estimate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The median follow-up time of 37 patients after treatment was 890 days (104-1062).

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PMC9429973

Among unfit pts, those receiving IC had significantly longer overall survival compared with pts receiving a VEN-based regimen (median overall survival, 14 vs 6 months, respectively; HR, 0.51 [95% CI, 0.27–0.98]; P = 0.042; Figure).

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PMC9031474

In further experiments, Fratoni et al. tested derivatives 16, 18, and 19 against 16 human cancer cell lines .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "further", "...

PMC8750422

Collectively, our results indicate that eNOS is a key mediator for GPR87 in the regulation of metastatic properties through the AKT-NO signaling pathway in lung adenocarcinoma.

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PMC11589157

We assembled over 16 Mb of Y-sequence, the second longest among reported gibbon genome data.

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PMC11679033

SH-SY5Y cells were grown in Dulbecco’s Modified Eagle’s Medium F12 containing 15% (v/v) fetal bovine serum (FBS), 2 mM glutamine, 1% (v/v) penicillin/streptomycin (PenStrep solution), and 1% (v/v) non-essential amino acids (NEAA solution).

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PMC9429973

Image: Summary/Conclusion: In this study with intensively treated newly diagnosed AML, we noticed a similar incidence of thrombosis to that previously reported.

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PMC10968586

ROS-mediated damage at least in part accounts for chemotherapy-dependent toxicity detected at the tissue level on non-cancer cells .

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PMC11753949

Such greater thickness is most likely due to actin crosslinking by synaptopodin not in contact with the ER.

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PMC8711270

In second generation AdV vectors, additional genes required for viral replication have been inactivated.

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PMC9429973

Multivariable analyses including IGLV3-21, disease stage, and IGHV gene SHM status or epigenetic subtypes confirmed the independent prognostic value of IGLV3-21 on TTFT (p<0.005).

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PMC7802142

NTA showed that the size of ReN-NV was < 200 nm mainly with peaks at 129 and 170 nm (Fig. 1b).

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PMC6364197

Flow cytometry analysis was performed to analyze whether the cell phenotype changes after cultivation in scaffold for one week.

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PMC11640555

This finding reasserts the efficacy of CK2 inhibitor CX-4945 as an anti-cancer and inflammatory agent against GBM.

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PMC11747467

P-value < 0.05; **, P-value < 0.01; ***, P-value < 0.001; ****, P-value < 0.0001.

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PMC7823217

Thus, bioprinted tumor models developed using organoids from patient-derived tumor cells of pleural effusion fluid exhibit in-vivo-like anatomy.

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PMC11449273

In the cytoplasm, plakoglobin reduces β-catenin level and its translocation into the nucleus/oncogenic activation.

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PMC9100622

Altogether, the data show that statins, which are off-patent, well-tolerated, and inexpensive compounds, should be strongly considered in the therapeutic arsenal against this deadly childhood disease.

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PMC11257988

Among them, immune checkpoint blockade therapy represented by PD-1/PD-L1 inhibitors (nivolumab) and CTLA-4 inhibitors (ipilimumab) has shown encouraging therapeutic effects in the treatment of various malignancies, such as non-small cell lung cancer (NSCLC) and melanoma, etc. .

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PMC11279397

However, previous studies have primarily focused on modeling virus infection in vitro using cell lines, with only a limited number of recent studies validating these findings through in vivo experiments in mice.

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PMC11787381

The number of NeuN positive pyramidal cells in the CA1 area was measured as well as AT100 into NeuN(+) pyramidal cells.

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PMC11764090

Finding the upstream temperature signal sensor of the plant cold-signaling pathway is a fundamental problem in future research because these receptors are very likely to play a switching function for the whole cold-signaling pathway.

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PMC9429973

Among vaccinated patients who suffered a severe/critical infection, 52% did not have vaccine seroconversion.

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PMC11352311

Fluorescence images were captured using a fluorescence microscope.

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PMC11544122

Loss of endogenous surface CXCR4 in HeLa cells was measured by flow cytometry as previously described.

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PMC11129910

In six patients (46.15%) who underwent axillary nodal dissection, lymph node metastases were present in two cases, and one of them had extracapsular extension.

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PMC11190538

C-phycocyanin consists of two subunits, α and β, which are found in equal quantities.

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PMC5363531

Compared with untreated, dasatinib treatment abolished cell migration capability to heal the scrape after 24 hours in both REN and MPP89 cell lines (left and middle panels), and after 8 hours in MSTO (right panel).

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PMC11593084

We have reported CasMabs against PDPN (LpMab-2 and LpMab-23 ), which were obtained by immunization of LN229/PDPN with mice.

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PMC7334607

Right: Two waterfall plots representing the samples ranked by their responses to the two drugs, vorinostat (SAHA, top) and SP-2509 (SP, bottom).

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PMC11670954

The metabolites produced by the microbiota are vital for maintaining health .

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PMC10808409

Transmission electron microscopy revealed spherical shaped globules with smooth surface.

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PMC9436459

On the basis of the position of dehydroprenyl unit, type D MDAAs are divided into two subgroups: type D-I (the diene moiety on ring A) and type D-II (the diene moiety on ring B), as illustrated by the structures of 92–104 and 105–113, respectively.

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PMC11422150

Sensory examination of the bilateral hind paw region of SCI mice was done by examining the paw withdrawal reflex after the application of a series of forces using TACTILE TEST (AESTHESIO) Semmes–Weinstein von Frey anesthesiometer (Muromachi Co. Ltd, Japan) (Godfrey et al., 2018; Ranade et al., 2014).

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PMC10957991

It may also be that in the lungs, the ability of TRPV4 to sense mechanical changes in the cell microenvironment is essential for the morphogenesis of all the tissue compartments within the lungs, including epithelium, smooth muscle layer and the vascular compartment.

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PMC11612626

Raw files were searched using a local copy of PEAKS with the following parameters: Database: Swiss-Prot mouse oval-chick for murine immunopeptidome or Swiss-Prot human for the myeloma immunopeptidome; fixed modification: none; variable modifications: oxidation (M), acetyl (N-terminus), carbamidomethyl (C); mass values:...

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PMC7823217

Image showing the OVCAR5 and MRC-5 cells at 8 day of coculture. (

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PMC5600151

PLL dendrimers of low generations have fewer primary amines, which was not optimal for complexing large nucleic acid molecules.

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PMC9429973

Besides, 7 patients were diagnosed with double-hit lymphoma and 4 patients were relapsed after previous CD19 CAR-T cell therapy.

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PMC10747160

While these values are not as potent as the inhibitory capabilities of Griffithsin against other viruses, these values are largely within the range of values expected for SARS-CoV-2 pseudoviral inhibition (Table S1) and are still considered to be potent enough for Griffithsin to be potentially used as a viable agent to...

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PMC11737091

GO terms and KEGG pathways of genes similar to DBF4. (

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PMC9878562

While VAL-ko alone did not migrate to the axillary lymph node, in the presence of VAL-wt or DOHH2 the CFP VAL-ko could readily be detected ( Figure 3B ).

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PMC6600592

Researches showed that HLA-A2 with the immunodominant HBcAg18–27 epitope (HLA-A2.1- restricted CTL epitope) binding peptides of vaccine or of HBcAg initiated specific respond of T cell and resolved cute HBV infection .

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PMC9429973

Image: Summary/Conclusion: Our study was the first one using scRNA-seq to disclose the tumor heterogeneity and immune microenvironment of RS and aCLL/SLL in single-cell dimension.

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PMC7039683

A supervised-machine-learning classifier, gapped k-mer support vector machine (gkmSVM) was used to generate a 10-fold larger set of random genomic 400 bp sequences in the danRer7 reference genome, based on matching of GC and repeat fraction of the positive training set.

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PMC10452486

The surface expression of Face-1 in the cell line was achieved by supplementing either with mouse or human B2m. The second is the R1 cell line of a somatic cell variant of the C3H (H-2) thymoma .

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PMC11243198

These interacting residues are positioned near the GLI1-ZF DNA binding site (Figure 6D) and are also conserved between GLI1 and GLI2 proteins (Figure 6D).

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PMC11011837

Moreover, within the context of T-ALL, cases labeled as ‘unclassified’ due to the absence of cytogenetic markers could benefit from multiomics approaches, such as metabolomics and lipidomics.

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PMC8753818

After 28 h , cells were fixed in 70% ethanol , and DNA was stained using PI in the presence of DNase-free RNase A (40 mg/mL) for 30 min at 37 °C in the dark circumstance.

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PMC11012012

In contrast, SLAMF2/CD48 binds to SLAMF4/CD244 and vice versa.

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PMC11687167

In the future, more researches and refinements are needed before these new approaches could be translated into clinical applications.

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PMC9429973

PD activity of IBER was not attenuated by prior refractoriness to immunomodulatory drugs (IMiD agents) or anti-CD38 therapy.

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PMC9429973

The safety profile was manageable.

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PMC11740573

It also reduces the need for excessive activation of pro-inflammatory defense mechanisms.

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PMC11718809

PYCR1 promotes intracellular amino acid metabolism during lactation and is associated with L-proline synthesis .

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PMC10204952

This “inside-out signaling” activates and/or promotes vast biological functions such as cell proliferation and survival, angiogenesis and T-cell migration [6–9].

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PMC11604768

FBS was purchased from Omega Scientific.

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PMC11457557

These ncRNAs might be used as biomarkers to determine possible targets for DKD prevention and therapy.

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PMC9429973

The improved OS emained significant (HR 0.043, 95% CI 0.003-0.63, p=0.021) in multivariate analysis when adjusted for sex, age, hypereosinophilia in the blood, PDGFRA/B fusion status, complex cytogenetics at diagnosis, the blastic-phase at diagnosis, and alloHSCT.

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PMC11755519

The EVs tested resulted in increased expression levels of α-SMA, FAP, and Galectin proteins.

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PMC11711345

The compounds showed high GI absorption, except for p-cymene according to the SwissADME server, suggesting that it is difficult for this compound to be absorbed across the intestine after oral intake.

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PMC11461874

Further studies on the temporal pattern of DBP phosphorylation at each site and those on the phospho-degron recognized by TRAF7 will unveil the mechanism underlying the time-of-the-day-dependent regulation of DBP protein level.

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PMC10758402

Nevertheless, it is apparent that additional efforts are required to enhance the effectiveness of this therapy.

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PMC11531735

These observations were further corroborated by analysis of brain tissue from the treatment group compared to controls.

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PMC10040136

Additionally, MSC were observed to secrete TGF-β2, consequently activating the PI3K-AKT pathway and augmenting GIST resistance.

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PMC10362265

Contrary to these two complexes, the heterodimers showed almost rigid backbones.

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PMC11583010

The injection sites and skin were observed for local reactions and evidence of toxicity.

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PMC11087766

For protein expression, LB was supplemented with 15 μg/mL gentamicin and 0.1% arabinose.

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PMC9429973

Pts randomized to KRd received carfilzomib 36 mg/m on days (D) 1,2,8,9,15,16 for 4 cycles (C) then D1,2,15,16 starting C5; R 25 mg D1-21, and dexamethasone 20 mg D1,8,15,22 in 28-day cycles.

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PMC11012012

Elotuzumab, a therapeutic anti-SLAMF7/CD319 antibody, induced dose-dependent ADCC activity toward BC2 target cells, using PBMCs as effector cells.

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PMC9429973

All the patients had previously been treated with schedule containing bortezomib and IMIDs.

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PMC11791478

Both ADCs use the microtubule polymerization inhibitor monomethyl auristatin E (MMAE) as the payload (18, 20).

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PMC11585994

In conclusion, G5-sgc8-siBCL11B nanoparticles effectively reduce T-ALL tumor burden and prolong survival in vivo.

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PMC11451940

Complexes 1 and 5 increased the number of cells arrested in the G2/M phase, while 7 arrested the majority of the A2780 cells in the G0/G1 phase.

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PMC9275501

NDCDS can change the original pharmacokinetic characteristics of drugs, so as to ensure that the combined drugs enter tumor cells with a constant proportion, which is conducive to the synergy between drugs.

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PMC9429973

In particular, we observed an enrichment of specific CD8+ T cell subsets in the CR group, while certain CD4+ T cell subsets, such as regulatory T cells were enriched in REL patients.

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PMC9429973

We recently identified Endomucin (EMCN) as a novel HSC marker, a transmembrane protein conserved in mouse and human throughout development, but not in lineage-committed haematopoietic progenitor cells.

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