OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11588008	This study found that the repair effects of HUC-MSCs may be related to the ERK–Nrf2–HO-1 pathway to increase GSH production and enhance the antioxidant capacity of granulosa cells, thereby improving the function of granulosa cells and providing a theoretical basis for HUC-MSCs to treat POI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Moreover, as already shown in Fig. 4, the gene expression of neuronal markers strongly correlated with the protein synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC9960565	= 974.82, m/z found = 974.65 [M+H] C238H562Cl29N116O92Pt29.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "=", "974.82", ",", "m/z", "found", "=", "974.65", "[", "M+H", "]", "C238H562Cl2...
PMC11547972	To evaluate clinical feasibility, the in vitro protocol must be applied to an in vivo model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "evaluate", "clinical", "feasibility", ",", ...
PMC10605143	CTNNB1 and SNAI1 had a distinct expression in all cell lines tested (Figure 5b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CTNNB1", "and", "SNAI1", "had", "a", "distinct", ...
PMC11659734	As an alternative, immortalised cell lines like HepG2, derived from human liver cancer, are frequently used (Khetani & Elsayed, 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190062	MM is a complex and heterogeneous disease, and expression levels of TLRs as well as downstream signaling components are likely to differ between patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9960565	Anionic half-generation PAMAM dendrimers G0.5 (19.19 w/w % in methanol), G1.5 (20.03 w/w % in methanol), G2.5 (9.98% w/w in methanol) or G2.5 (3.43 w/w % in water), and G3.5 (10.04 w/w % in methanol) with an ethylenediamine core were acquired from Dendritech Inc. Cis-diamminedichloroplatinum (II) (cisplatin 99.99%) was...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Additionally, fewer adverse events of febrile neutropenia (28.2% vs 34.2%) and infections (28.2% vs 49.3%) were reported in the IVO+AZA arm compared to the placebo+AZA arm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	infusion with enadenotucirev to assess delivery in patients with NSCLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "infusion", "with", "enadenotucirev", "to", "assess", "delivery", "in", "patients", "with", "NSCL...
PMC11607638	24 h after injection, a blood meal weighing experiment was conducted. ****	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "24", "h", "after", "injection", ",", "a", "blood...
PMC7823217	Moreover, immune cells within the stroma also play important roles in modifying the tumor microenvironment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "immune", "cells", "within", "the", ...
PMC9429973	IL-10 blockade has been shown to enhance T-cell immunity, and may be a potential therapeutic target.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IL-10", "blockade", "has", "been", "shown", ...
PMC11638288	Yotam et al. demonstrated that the recognition and activation abilities of NKp46 and NCR1 were lost when the virus was incubated with SLL (a soluble sugar containing sialic acid).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	Doses of 6 mg/kg and 12 mg/kg were deemed close to the expected therapeutic dose, while a dose of 1.2 mg/kg was considered below the required therapeutic level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	5 out of the 11 (45%) pts performed Ly-apheresis before ASCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5", "out", "of", "the", "11", "(", "45", "%", ")", "...
PMC10823017	A P value of less than or equal to 0.05 indicated statistical significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "P", "value", "of", "less", "than", "or", "equal", "to", "0...
PMC10605143	Analyzing cell growth in Matrigel, we found that two cell lines with the highest HSF1 levels (BT-549 and HCC1395), although they differed greatly in their ability to migrate, both exhibited a stellate (invasive) phenotype (Figure 5f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11721295	Nonsmokers have poorer prognosis with worse outcomes to immunotherapies than smokers (3), possibly due to lower mutation burden — and thus, lower neoantigen prevalence and fewer changes in the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	Proteins were isolated from cellular samples using RIPA buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "isolated", "from", "cellular", "samples", "using", "RIPA", "buffer", "." ] } ]
PMC11687167	Evolocumab (AMG 145) and alirocumab (SAR236553/REGN727) are fully human immunoglobulin G2 and G1 mAb, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Evolocumab", "(", "AMG", ...
PMC11040965	B Representative western blot of PI3K/AKT pathway components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Representative", "western", "blot", "of", "PI3K/AKT", "pathway", "components", "." ] } ]
PMC11201245	Influencing immune cells or fibroblasts are likely to differ in their diploid character from the OC cells, whose chromoanagenesis can be detected by the OC-FISH test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11347429	Blood samples were collected at admission or from patients in the ICU at the time of consent (the first sample taken was assigned as day 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791264	Cells were rinsed with ice-cold phosphate-buffered saline (PBS) and lysed with the radioimmunoprecipitation assay (RIPA, sc-24948, Santa Cruz Biotechnology) buffer supplemented with protease inhibitors, including aprotinin and leupeptin (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	Figure 6Internalization of the aptamer into cells(A) Aptamer (ATOP and SCR) internalization into RH4 and A673 was evaluated by qRT-PCR and normalized to an internal RNA reference control for PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	None of the cell lines demonstrated a two-fold increase in expression of LATS1 or LATS2 with treatment with 5-azacytidine (Figure 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "None", ...
PMC9436459	0.5 μg/mL (5-FU)Guangsangon E (56)P-3882.75 μg/mL ; 2.5 μg/mL –Sorocein I (65)P-388n.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "0.5", "μg/mL", "(5-FU)Guangsangon", "E", "(56)P-3882.75", "μg/mL", ";", "2.5", "...
PMC9545714	In one study, an olfactory receptor (OR2AT4) that responds to a synthetic sandalwood odorant was identified in keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "one", "stud...
PMC11742290	Overexpression of LGR5 enhanced chemo-resistance in CRC cells whilst LGR5-KD cells were more sensitive to 5-FU chemotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "LGR5", "enhanced", "chemo...
PMC11271278	HAPI analysis of HiChIP data from 34 cancer cell lines identified enhancer hijacking events that activate both known and potentially novel oncogenes such as MYC, CCND1, ETV1, CRKL, and ID4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	A431 cells were seeded in 12-wells plates (10 cells/well) in growth medium.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A431", "cells", "were", "seeded", "in", "12-wells", "plates",...
PMC8469018	The qPCR was conducted using TaqMan Gene Expression Assays (USA, Life Technologies): DHODH- Hs00361406_mi, 18S-Hs99999901_s1, and ACTB-Hs03023943_g1, according to manufacturer’s instructions in a 7500 Fast Real-Time PCR System (ThermoFisher, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	Scale bar = 100 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "=", "100", "μm", ".", "(" ] } ]
PMC11544122	SNX9 belongs to the sorting nexin (SNX) family of proteins comprising 33 members that are involved in endosomal sorting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SNX9", "belongs", ...
PMC11640247	These GTPases are crucial regulators of actin cytoskeleton dynamics and intracellular signaling, influencing cell morphology, migration, adhesion, and the cell cycle in various cellular contexts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Wild-type (WT) effectors are compared to their mutants (E/A or C/S).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wild-type", "(", "WT", ")", "effectors", "are", "compared",...
PMC10808409	TEM revealed that the TPGS mixed micelles had a smooth surface and a spherical shape which was reported to have better cellular uptake than other shapes such as the rod-shaped micelles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	Data are means ± SEM (n = 3 in each group) p < 0.05; *p < 0.01 Concomitantly, the impact of the aforementioned interventions on GIST cell growth inhibition by IM was assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	To apply the TCR scoring functions to data outside of the training set, we extracted the same 1250 TCR sequence features, multiplied each TCR feature value by its respective weight learned in from Dataset 1 and 2, and took the sum of these 1250 products.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	The cells were cultured in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum (Bio-Whittaker, Verviers, Belgium) and 40 mg/ml gentamicin (Lek, Ljubljana, Slovenia) in a humidified atmosphere with 5% CO2 at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	Immunofluorescence analysis of the β-catenin levels in the nucleus of MRTX1133-resistant cells and its parental cells treated with 1 µM MRTX1133 for 48 h. Scale bar: 10 μm. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087766	PhiPA3 PicA (Fig. 2I) and Goslar PicA (gp174) (Fig. 2J) also localized in a single punctum at the nuclear periphery during infection of their respective hosts, P. aeruginosa and E. coli.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	Appassakij et al. (2020) reported that individuals infected with CHIKV can also be potential disease spreaders through blood transfusions or transplants, especially during an outbreak period.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given the fact that it was administered to heavily pretreated patients, caution to opportunistic pathogens should be paid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "the", "fact", "that", ...
PMC10772747	Previous studies have shown that the compounds in EBE have significant anticancer activity, including the inhibition of breast cancer cell proliferation (Mutiah et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10545062	This observation suggests that our simplified approach to assessing the need for fluid administration requires more data than simply analyzing the MAP response to a fluid challenge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	Of the 15 A-673 cells tested, 10 cells exhibited a reduction in outward currents after drug application (Fig. 2D).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", ...
PMC11610461	PSENEN was found to be highly expressed in KIRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PSENEN", "was", "found", "to", "be", "highly", "expressed", "in", "KIRC", "." ] } ]
PMC10758402	Images and corresponding viral titers ( Figure 2B ) show a clear enhancement of HSV.n212 following pretreatment with DMF in CT26.wt cores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "an...
PMC11695546	According to many reports, a number of factors affect the general efficacy of ozonated derivatives, including: (i) the kind and caliber of ozone producers; (ii) the ozonation circumstances, including reactor type and duration, substance kind and quantity, existence of water and/or catalysts; and (iii) the ozonizer's ef...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718031	A similar result was found in previous studies by Costa et.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "result", "was", "found", "in", "previous", "studies", "by", "Costa", ...
PMC11464982	Table 3 provides an overview of the derived exposure estimates across all surveys.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "3", "provides", "an", "overview", "of", "the", "derived", "e...
PMC11752740	Additionally, there was a marked decline in NF-κB p65 expression at 48 h across all treatment groups when compared to the 24 h results (noted with †).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	The cell viability was determined by MTS assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "viability", "was", "determined", "by", "MTS", "assay", ".", "(" ] } ]
PMC9429973	Currently, there are no head-to-head trials comparing the efficacy of tec versus physician’s choice of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "there", "are", "no",...
PMC11588008	The membranes were incubated with primary antibody against Nrf2, HO-1 (Sigma, America), ERK, p-ERK (CST, America), and β-actin (Affinity, America) overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9479186	It may indicate that autophagy was inhibited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "may", "indicate", "that", "autophagy", "was", "inhibited", "." ] } ]
PMC11564322	Interestingly, c-SRC kinase is upregulated in HL-60 and K562 cells during their differentiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "c-SRC", "kinase", "is", "upregulated...
PMC10317042	Gene expression was measured using a StepOnePlus Real Time PCR System (Applied Biosystems) and SYBR Green Realtime PCR Master Mix (Toyobo).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7987994	Collectively, it could make the different studies more comparable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "it", "could", "make", "the", "different", "studies", "more", "comparable", ...
PMC11720808	The sequencing library was analyzed on the NovaSeq 6000 platform (Illumina) by Beijing Qinglian Biotech Co., Ltd. To evaluate whether SCU could bind directly to TLR4, we performed molecular docking analysis of SCU with TLR4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	The DMSO control is a representation of a normal cell cycle showing regular mitotic division approximately every 22 to 24 hours (representative images shown in Fig. 3b and Sup Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11400680	Different thresholds of IoU, for example, 50, 75, and 95 can be applied during AP calculation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "thresholds", "o...
PMC11569208	Finally, to confirm the proposed mechanism of action of IFN-1 repression by our novel VSV∆51-shACP2, we analyzed 786-0 cell lysates infected for 24 h with VSV∆51-shACP2 for IFN-1 effectors, MX2 and IFITM1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O"...
PMC6835428	HA, a polymer of natural origin, is a linear polysaccharide formed by glucuronic acid and N-acetylglucosamine units linked via alternating –1,4 and –1,3 glycosidic bonds (Figure 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11093197	Loss of RB1 activates RAS via upregulation of isoprenylation‐related genes through the E2F pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Loss", "of", "RB1", "activates", "RAS", "via", "upregulation", "...
PMC9429973	Image: Summary/Conclusion: Second line treatment for MCL was very heterogenous in terms of treatment and outcomes and was likely impacted by 1L treatment and other clinical factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Key exclusionary criteria were receipt of any prior antileukemic therapy, stem cell transplant within 6 months of AZA initiation, active second malignancies, participation in a clinical trial during the study period, or off-label use of AZA regimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	Limited promoter methylation profiles of a number of tumor suppressor genes have been reported in intrahepatic and extrahepatic cholangiocarcinoma [16-18].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11519788	Next, we validated the expression levels of eight STAT3 target genes 23-25, including CCL2, IL6R and SOX2, which were induced in 5637 cells with SPOP depletion and suppressed in T24 cells overexpressing SPOP, compared to their controls (Figure S3B-C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	In pre-clinical models of prostate cancer, it has been found that the sympathetic nervous system effects were mediated principally by β2- and β3-ARs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10577955	Bax, CASP-8, CD95 (cluster of differentiation 95), Bcl-2, KRAS (Kirsten rat sarcoma viral oncogene), VEGF, Cyclin D1, and the housekeeping gene β-actin were among the target genes for which highly purified primers were created (Sigma, USA) (Supplementary Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Collectively, the data showed that like in myeloma, daratumumab may block binding of some diagnostic antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "the", "data", "sh...
PMC11701801	P < 0.05; , P < 0.01; *, P < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ";", "", "", ...
PMC9429973	Methods: This was a retrospective cohort study done at NIBD PECHS campus from 2020-2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", "was", "a", "retrosp...
PMC11730000	In the present study, 0.5 and 1 mM RA exerted protective effects against DOX-induced genotoxicity in CHO-K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "the", "present", "...
PMC11334037	We injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "injected", ...
PMC10671321	These differences are probably related to the location of the variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "differences", "are", "probably", "related", "to", "the", "location", "of", "...
PMC11705067	The mutation frequencies of FDX1 and DLAT in ccRCC patients were explored through the cBioPortal database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mutation", "frequencies", "of", "FDX1", "and", ...
PMC8270637	The flow cytometry results ( Figures 5G, H ) and qPCR results ( Figures 5I, J ) also showed that SB431542 and CsA inhibited PD-1 and CTLA-4 expression induced by TGF-β1 in T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	This phenomenon complicates the traditional understanding of angiogenesis, as it suggests that tumor cells themselves can participate in creating their vascular supply, further supporting their growth and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10571053	Cross-resistance profile of transfected A673 cells Results presented are mean GI50 values +/- SEM (µM).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cross-resistance", "profile", "of", ...
PMC10123657	Other proteins associated with the actin cytoskeleton and regulation of cell shape in Figure 3A, probably reflect transfer through the actin-rich tunneling nanotubes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10706275	This aligns more closely with good manufacturing practice standards in pharmaceutical production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "aligns", "more", "closely", "with", "good", "manufacturing", "practice", ...
PMC8481254	Fig. 4A, B RT-qPCR assay detected the mRNA expression levels of 25 different kinases in Bel-7402 and Bel-7404 cells and detailed information on one overlapping gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC10547921	But not until 1975, when the development of hybridoma technology started being used to produce monoclonal antibodies really began the era of developing ADC drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6034753	For further confirmation of the interaction, we also carried out the reverse experiment asking whether N-terminal GST-Meq (1–170 aa) fusion protein can pull down apoptin from the cell lysates of U2OS cell line that expressed N-terminal FLAG-tagged apoptin from a doxycycline-inducible construct.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	It is not clear why pl9 protein is produced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "not", "clear", "why", "pl9", "protein", "is", "produced", "." ] } ]
PMC10899471	Further mechanistic studies demonstrated that miR-939-3p promoted sarcoma cell proliferation via binding to the 3’ UTR of BATF2 ( Figure 7 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8389560	When cells were treated with Gap26 virtually no significant changes were observed in gene expression for most of the studied pro-apoptotic proteins, except for CHOP, GADD34, and BAX by 1.7, 1.8, and 1.5 times, respectively (Figure 7E, black columns).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	The results are consistent with the transwell assays and the in vivo data, demonstrating that the presence of ACKR3 is essential to promote migration in cis and in trans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: Describe the finding and management of an inhibitor against clotting FV in an CLL diagnosed patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Describe", "the", "findin...
PMC5925824	Hence, LY3300054 blocks the PD-1/PD-L1 interaction because its binding epitope overlaps the binding site of PD-1 on PD-L1.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "LY3300054", "blocks...
PMC8316344	Labile iron was measured by Iron Assay Kit before and after TRIB2 was knocked out in Bel-7404 cells with siRNA-mediated knockdown for indicated iron regulators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11678130	One of the basic drawbacks of 5-FU chemotherapy is the development of resistance related to the presence of cancer stem-like cells (CSCs) within the cancer cell niche .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727145	Early experiments using epidermis-free dermis for skin tissue regeneration date back to the last century .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "experiments", "using", "epidermis-free", "dermis", "for"...
PMC11413393	Once tumors were established in the renal capsule, tissue was harvested and finely minced using a scalpel, then incubated in 1× Collagenase/Hyaluronidase and 125 Units/mL DNase (Stem Cell Technologies) with frequent pipetting at 37 °C for 2 h. Red blood cells were lysed with ammonium-chloride/potassium (ACK) lysing buf...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	MSC can also be retrieved from neonatal tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MSC", "can", "also", "be", "retrieved", "from", "neonatal", "tissues", "." ] } ]
PMC9429973	Image: Summary/Conclusion: SB12 showed clinical equivalence to ECU measured by LDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "SB12", "showed", "clinical", "equi...

PMC11588008

This study found that the repair effects of HUC-MSCs may be related to the ERK–Nrf2–HO-1 pathway to increase GSH production and enhance the antioxidant capacity of granulosa cells, thereby improving the function of granulosa cells and providing a theoretical basis for HUC-MSCs to treat POI.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

Moreover, as already shown in Fig. 4, the gene expression of neuronal markers strongly correlated with the protein synthesis.

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PMC9960565

= 974.82, m/z found = 974.65 [M+H] C238H562Cl29N116O92Pt29.

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PMC11547972

To evaluate clinical feasibility, the in vitro protocol must be applied to an in vivo model.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "evaluate", "clinical", "feasibility", ",", ...

PMC10605143

CTNNB1 and SNAI1 had a distinct expression in all cell lines tested (Figure 5b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CTNNB1", "and", "SNAI1", "had", "a", "distinct", ...

PMC11659734

As an alternative, immortalised cell lines like HepG2, derived from human liver cancer, are frequently used (Khetani & Elsayed, 2013).

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PMC11190062

MM is a complex and heterogeneous disease, and expression levels of TLRs as well as downstream signaling components are likely to differ between patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9960565

Anionic half-generation PAMAM dendrimers G0.5 (19.19 w/w % in methanol), G1.5 (20.03 w/w % in methanol), G2.5 (9.98% w/w in methanol) or G2.5 (3.43 w/w % in water), and G3.5 (10.04 w/w % in methanol) with an ethylenediamine core were acquired from Dendritech Inc. Cis-diamminedichloroplatinum (II) (cisplatin 99.99%) was...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Additionally, fewer adverse events of febrile neutropenia (28.2% vs 34.2%) and infections (28.2% vs 49.3%) were reported in the IVO+AZA arm compared to the placebo+AZA arm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10976516

infusion with enadenotucirev to assess delivery in patients with NSCLC.

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PMC11607638

24 h after injection, a blood meal weighing experiment was conducted. ****

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PMC7823217

Moreover, immune cells within the stroma also play important roles in modifying the tumor microenvironment .

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PMC9429973

IL-10 blockade has been shown to enhance T-cell immunity, and may be a potential therapeutic target.

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PMC11638288

Yotam et al. demonstrated that the recognition and activation abilities of NKp46 and NCR1 were lost when the virus was incubated with SLL (a soluble sugar containing sialic acid).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721277

Doses of 6 mg/kg and 12 mg/kg were deemed close to the expected therapeutic dose, while a dose of 1.2 mg/kg was considered below the required therapeutic level.

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PMC9429973

5 out of the 11 (45%) pts performed Ly-apheresis before ASCT.

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PMC10823017

A P value of less than or equal to 0.05 indicated statistical significance.

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PMC10605143

Analyzing cell growth in Matrigel, we found that two cell lines with the highest HSF1 levels (BT-549 and HCC1395), although they differed greatly in their ability to migrate, both exhibited a stellate (invasive) phenotype (Figure 5f).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "...

PMC11721295

Nonsmokers have poorer prognosis with worse outcomes to immunotherapies than smokers (3), possibly due to lower mutation burden — and thus, lower neoantigen prevalence and fewer changes in the tumor microenvironment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11763126

Proteins were isolated from cellular samples using RIPA buffer.

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PMC11687167

Evolocumab (AMG 145) and alirocumab (SAR236553/REGN727) are fully human immunoglobulin G2 and G1 mAb, respectively.

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PMC11040965

B Representative western blot of PI3K/AKT pathway components.

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PMC11201245

Influencing immune cells or fibroblasts are likely to differ in their diploid character from the OC cells, whose chromoanagenesis can be detected by the OC-FISH test.

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PMC11347429

Blood samples were collected at admission or from patients in the ICU at the time of consent (the first sample taken was assigned as day 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11791264

Cells were rinsed with ice-cold phosphate-buffered saline (PBS) and lysed with the radioimmunoprecipitation assay (RIPA, sc-24948, Santa Cruz Biotechnology) buffer supplemented with protease inhibitors, including aprotinin and leupeptin (Sigma-Aldrich).

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PMC10213179

Figure 6Internalization of the aptamer into cells(A) Aptamer (ATOP and SCR) internalization into RH4 and A673 was evaluated by qRT-PCR and normalized to an internal RNA reference control for PCR.

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PMC6114978

None of the cell lines demonstrated a two-fold increase in expression of LATS1 or LATS2 with treatment with 5-azacytidine (Figure 5C).

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PMC9436459

0.5 μg/mL (5-FU)Guangsangon E (56)P-3882.75 μg/mL ; 2.5 μg/mL –Sorocein I (65)P-388n.a.

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PMC9545714

In one study, an olfactory receptor (OR2AT4) that responds to a synthetic sandalwood odorant was identified in keratinocytes.

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PMC11742290

Overexpression of LGR5 enhanced chemo-resistance in CRC cells whilst LGR5-KD cells were more sensitive to 5-FU chemotherapy .

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PMC11271278

HAPI analysis of HiChIP data from 34 cancer cell lines identified enhancer hijacking events that activate both known and potentially novel oncogenes such as MYC, CCND1, ETV1, CRKL, and ID4.

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PMC11740573

A431 cells were seeded in 12-wells plates (10 cells/well) in growth medium.

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PMC8469018

The qPCR was conducted using TaqMan Gene Expression Assays (USA, Life Technologies): DHODH- Hs00361406_mi, 18S-Hs99999901_s1, and ACTB-Hs03023943_g1, according to manufacturer’s instructions in a 7500 Fast Real-Time PCR System (ThermoFisher, USA).

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PMC11628904

Scale bar = 100 μm. (

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PMC11544122

SNX9 belongs to the sorting nexin (SNX) family of proteins comprising 33 members that are involved in endosomal sorting.

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PMC11640247

These GTPases are crucial regulators of actin cytoskeleton dynamics and intracellular signaling, influencing cell morphology, migration, adhesion, and the cell cycle in various cellular contexts .

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PMC11098378

Wild-type (WT) effectors are compared to their mutants (E/A or C/S).

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PMC10808409

TEM revealed that the TPGS mixed micelles had a smooth surface and a spherical shape which was reported to have better cellular uptake than other shapes such as the rod-shaped micelles.

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PMC10040136

Data are means ± SEM (n = 3 in each group) *p < 0.05; **p < 0.01 Concomitantly, the impact of the aforementioned interventions on GIST cell growth inhibition by IM was assessed.

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PMC11785489

To apply the TCR scoring functions to data outside of the training set, we extracted the same 1250 TCR sequence features, multiplied each TCR feature value by its respective weight learned in from Dataset 1 and 2, and took the sum of these 1250 products.

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PMC4485648

The cells were cultured in Dulbecco’s modified Eagle’s medium supplemented with 10% fetal calf serum (Bio-Whittaker, Verviers, Belgium) and 40 mg/ml gentamicin (Lek, Ljubljana, Slovenia) in a humidified atmosphere with 5% CO2 at 37°C.

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PMC11536589

Immunofluorescence analysis of the β-catenin levels in the nucleus of MRTX1133-resistant cells and its parental cells treated with 1 µM MRTX1133 for 48 h. Scale bar: 10 μm. (

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PMC11087766

PhiPA3 PicA (Fig. 2I) and Goslar PicA (gp174) (Fig. 2J) also localized in a single punctum at the nuclear periphery during infection of their respective hosts, P. aeruginosa and E. coli.

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PMC8524093

Appassakij et al. (2020) reported that individuals infected with CHIKV can also be potential disease spreaders through blood transfusions or transplants, especially during an outbreak period.

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PMC9429973

Given the fact that it was administered to heavily pretreated patients, caution to opportunistic pathogens should be paid.

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PMC10772747

Previous studies have shown that the compounds in EBE have significant anticancer activity, including the inhibition of breast cancer cell proliferation (Mutiah et al., 2019).

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PMC10545062

This observation suggests that our simplified approach to assessing the need for fluid administration requires more data than simply analyzing the MAP response to a fluid challenge.

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PMC11657695

Of the 15 A-673 cells tested, 10 cells exhibited a reduction in outward currents after drug application (Fig. 2D).

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PMC11610461

PSENEN was found to be highly expressed in KIRC.

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PMC10758402

Images and corresponding viral titers ( Figure 2B ) show a clear enhancement of HSV.n212 following pretreatment with DMF in CT26.wt cores.

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PMC11695546

According to many reports, a number of factors affect the general efficacy of ozonated derivatives, including: (i) the kind and caliber of ozone producers; (ii) the ozonation circumstances, including reactor type and duration, substance kind and quantity, existence of water and/or catalysts; and (iii) the ozonizer's ef...

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PMC11718031

A similar result was found in previous studies by Costa et.

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PMC11464982

Table 3 provides an overview of the derived exposure estimates across all surveys.

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PMC11752740

Additionally, there was a marked decline in NF-κB p65 expression at 48 h across all treatment groups when compared to the 24 h results (noted with †).

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PMC5308810

The cell viability was determined by MTS assay. (

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PMC9429973

Currently, there are no head-to-head trials comparing the efficacy of tec versus physician’s choice of therapy.

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PMC11588008

The membranes were incubated with primary antibody against Nrf2, HO-1 (Sigma, America), ERK, p-ERK (CST, America), and β-actin (Affinity, America) overnight.

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PMC9479186

It may indicate that autophagy was inhibited.

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PMC11564322

Interestingly, c-SRC kinase is upregulated in HL-60 and K562 cells during their differentiation .

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PMC10317042

Gene expression was measured using a StepOnePlus Real Time PCR System (Applied Biosystems) and SYBR Green Realtime PCR Master Mix (Toyobo).

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PMC7987994

Collectively, it could make the different studies more comparable.

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PMC11720808

The sequencing library was analyzed on the NovaSeq 6000 platform (Illumina) by Beijing Qinglian Biotech Co., Ltd. To evaluate whether SCU could bind directly to TLR4, we performed molecular docking analysis of SCU with TLR4.

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PMC11225860

The DMSO control is a representation of a normal cell cycle showing regular mitotic division approximately every 22 to 24 hours (representative images shown in Fig. 3b and Sup Fig. 3).

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PMC11400680

Different thresholds of IoU, for example, 50, 75, and 95 can be applied during AP calculation.

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PMC11569208

Finally, to confirm the proposed mechanism of action of IFN-1 repression by our novel VSV∆51-shACP2, we analyzed 786-0 cell lysates infected for 24 h with VSV∆51-shACP2 for IFN-1 effectors, MX2 and IFITM1.

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PMC6835428

HA, a polymer of natural origin, is a linear polysaccharide formed by glucuronic acid and N-acetylglucosamine units linked via alternating –1,4 and –1,3 glycosidic bonds (Figure 5F).

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PMC11093197

Loss of RB1 activates RAS via upregulation of isoprenylation‐related genes through the E2F pathway.

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PMC9429973

Image: Summary/Conclusion: Second line treatment for MCL was very heterogenous in terms of treatment and outcomes and was likely impacted by 1L treatment and other clinical factors.

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PMC9429973

Key exclusionary criteria were receipt of any prior antileukemic therapy, stem cell transplant within 6 months of AZA initiation, active second malignancies, participation in a clinical trial during the study period, or off-label use of AZA regimens.

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PMC4112127

Limited promoter methylation profiles of a number of tumor suppressor genes have been reported in intrahepatic and extrahepatic cholangiocarcinoma [16-18].

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PMC11519788

Next, we validated the expression levels of eight STAT3 target genes 23-25, including CCL2, IL6R and SOX2, which were induced in 5637 cells with SPOP depletion and suppressed in T24 cells overexpressing SPOP, compared to their controls (Figure S3B-C).

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PMC10887351

In pre-clinical models of prostate cancer, it has been found that the sympathetic nervous system effects were mediated principally by β2- and β3-ARs .

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PMC10577955

Bax, CASP-8, CD95 (cluster of differentiation 95), Bcl-2, KRAS (Kirsten rat sarcoma viral oncogene), VEGF, Cyclin D1, and the housekeeping gene β-actin were among the target genes for which highly purified primers were created (Sigma, USA) (Supplementary Table S1).

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PMC9429973

Collectively, the data showed that like in myeloma, daratumumab may block binding of some diagnostic antibodies.

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PMC11701801

P < 0.05; **, P < 0.01; ***, P < 0.001.

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PMC9429973

Methods: This was a retrospective cohort study done at NIBD PECHS campus from 2020-2021.

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PMC11730000

In the present study, 0.5 and 1 mM RA exerted protective effects against DOX-induced genotoxicity in CHO-K1 cells.

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PMC11334037

We injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of GIST.

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PMC10671321

These differences are probably related to the location of the variants.

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PMC11705067

The mutation frequencies of FDX1 and DLAT in ccRCC patients were explored through the cBioPortal database.

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PMC8270637

The flow cytometry results ( Figures 5G, H ) and qPCR results ( Figures 5I, J ) also showed that SB431542 and CsA inhibited PD-1 and CTLA-4 expression induced by TGF-β1 in T cells.

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PMC11659921

This phenomenon complicates the traditional understanding of angiogenesis, as it suggests that tumor cells themselves can participate in creating their vascular supply, further supporting their growth and metastasis.

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PMC10571053

Cross-resistance profile of transfected A673 cells Results presented are mean GI50 values +/- SEM (µM).

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PMC10123657

Other proteins associated with the actin cytoskeleton and regulation of cell shape in Figure 3A, probably reflect transfer through the actin-rich tunneling nanotubes .

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PMC10706275

This aligns more closely with good manufacturing practice standards in pharmaceutical production.

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PMC8481254

Fig. 4A, B RT-qPCR assay detected the mRNA expression levels of 25 different kinases in Bel-7402 and Bel-7404 cells and detailed information on one overlapping gene.

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PMC10547921

But not until 1975, when the development of hybridoma technology started being used to produce monoclonal antibodies really began the era of developing ADC drugs.

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PMC6034753

For further confirmation of the interaction, we also carried out the reverse experiment asking whether N-terminal GST-Meq (1–170 aa) fusion protein can pull down apoptin from the cell lysates of U2OS cell line that expressed N-terminal FLAG-tagged apoptin from a doxycycline-inducible construct.

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PMC8759873

It is not clear why pl9 protein is produced.

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PMC10899471

Further mechanistic studies demonstrated that miR-939-3p promoted sarcoma cell proliferation via binding to the 3’ UTR of BATF2 ( Figure 7 ).

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PMC8389560

When cells were treated with Gap26 virtually no significant changes were observed in gene expression for most of the studied pro-apoptotic proteins, except for CHOP, GADD34, and BAX by 1.7, 1.8, and 1.5 times, respectively (Figure 7E, black columns).

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PMC9878562

The results are consistent with the transwell assays and the in vivo data, demonstrating that the presence of ACKR3 is essential to promote migration in cis and in trans.

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PMC9429973

Aims: Describe the finding and management of an inhibitor against clotting FV in an CLL diagnosed patient.

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PMC5925824

Hence, LY3300054 blocks the PD-1/PD-L1 interaction because its binding epitope overlaps the binding site of PD-1 on PD-L1.Fig.

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PMC8316344

Labile iron was measured by Iron Assay Kit before and after TRIB2 was knocked out in Bel-7404 cells with siRNA-mediated knockdown for indicated iron regulators.

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PMC11678130

One of the basic drawbacks of 5-FU chemotherapy is the development of resistance related to the presence of cancer stem-like cells (CSCs) within the cancer cell niche .

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PMC11727145

Early experiments using epidermis-free dermis for skin tissue regeneration date back to the last century .

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PMC11413393

Once tumors were established in the renal capsule, tissue was harvested and finely minced using a scalpel, then incubated in 1× Collagenase/Hyaluronidase and 125 Units/mL DNase (Stem Cell Technologies) with frequent pipetting at 37 °C for 2 h. Red blood cells were lysed with ammonium-chloride/potassium (ACK) lysing buf...

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PMC11488203

MSC can also be retrieved from neonatal tissues.

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PMC9429973

Image: Summary/Conclusion: SB12 showed clinical equivalence to ECU measured by LDH.

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