OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11767582	C NMR (75 MHz, CDCl3) δ 153.7, 138.9, 136.7, 135.7, 133.5, 132.0, 129.9, 129.4, 125.4, 103.0, 61.2, 56.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711127	In this review we aim to define these boarders by providing new perspectives to long-standing theories of tolerance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "review", "we", "aim", ...
PMC3734024	p<0.01.	[ { "tags": [ "O", "O" ], "tokens": [ "p<0.01", "." ] } ]
PMC10589262	One-way ANOVA with a post-hoc test was performed to compare multiple means (p < 0.05, p < 0.01, **p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	Parent mouse 1929, that did not develop a tumour, is shown as a comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parent", "mouse", "1929", ",", "that", "did", "n...
PMC11746948	After that, the gel was incubated with destaining buffer (50% CH3OH, 40% water, and 10% acetic acid) by shaking for 2–8 h and then incubated in water to help lower the background.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	The cells were then rinsed three times with the medium and incubated for 30 min, after which they were placed on the stage of an inverted microscope (BX51W1; Olympus, Tokyo, Japan) and continuously superfused at a flow speed of 1 mL/min with a bath solution containing 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 2 mM MgCl2, 10 m...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	These results demonstrate that the DNP1 can accurately identify target cells through a three-layer two-input Boolean operation, in which both aptamer and Nb-based molecular recognitions are involved into the molecular computation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9910796	A DNA library was generated using 500 ng of purified viral DNA with the DNA Prep Tagmentation (Illumina) kit and the Illumina DNA/RNA UD Indexes Set A(IDT) adapters, following the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11332076	Takayuki Harada: Writing – review & editing, Writing – original draft, Project administration, Funding acquisition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Takayuki", "Harada", ":", "Writin...
PMC11413393	All ‘epiprobe’ compounds were purchased from Cayman Chemical, Millipore-Sigma or MedChemExpress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "‘", "epiprobe", "’", "compounds", "were", "purchased", "f...
PMC11209164	While our study included only a limited number of patient specimens, the observation of substantial activity of TPF with oncolytic VSVΔ51 in human pancreatic and ovarian cancer tumor explants (Figure 3E) offers choice areas for further pre-clinical exploration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	The function of YTHDF2 in ccRCC remains uncertain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "function", "of", "YTHDF2", "in", "ccRCC", "remains", "uncertain", "." ] } ]
PMC11472569	These EVs can alter the transcriptional environment of recipient cells, thereby reflecting the donor MDR phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "EVs", "can", "alter", "the", "tran...
PMC10568263	The MnO2 nanoflowers were synthesized by dissolving 0.53 g MnSO4 and 1.33 g KMnO4 in 40 mL of DI water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MnO2", "nanoflowers",...
PMC5941560	Long deletions and duplications from Jurkat were also found in ClinVar, but the annotations do not contain gene information and are generally less informative (Additional files 2 and 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11461874	A heterodimer of CLOCK and BMAL1 binds to E-box DNA sequences (CACGTG and its related sequences) to activate transcription of thousands of genes including Per and Cry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Cotreatment with ML385 markedly abrogated macropinosomes formation (Figure 5B) and the cell death induced by TSL (Figure 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cotreatment", ...
PMC11678130	A well-known phytocompound with a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antihypertensive, vasodilatory, antiatherosclerotic, antiangiogenic, and antineoplastic properties, is quercetin (QUE), a flavonoid that is widely distributed in apples, berries, grapes, onions, tomatoes...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	These patients were not selected for HR mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "patients", "were", "not", "selected", "for", "HR", "mutations", "." ] } ]
PMC11634027	Wing hair polarity angles were plotted as a Rose plot using MATLAB (MathWorks).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wing", "hair", "polarity", "angles", "were", "plotted", "as...
PMC11024707	Mi-RNA-28-3p was shown to target various cancer-related genes and is a mi-RNA potentially involved in cell proliferation and migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mi-RNA-28", "-", ...
PMC10538569	Every 3 days, 1.2 ml culture supernatants were collected and replaced with fresh complete RPMI 1640 medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "3", "days", ",", "1.2", ...
PMC11609529	VPF (T3112) and CA3 (T4309) were purchased from TargetMol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VPF", "(", "T3112", ")", "and", "CA3", "(", "T4309", ")", "were...
PMC10291556	Condition of analyses: RP HPLC: gradient 0–100% B in 15 min (A = 0.1% TFA, B = ACN).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11529598	Our results demonstrated that miR-3154 was significantly up-regulated in glioblastoma tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "demonstrated", "that", "miR-3154", "was", "significantly", "up-regulated", ...
PMC11665584	Subpopulations of skin keratinocytes from PITX1 mice were shifted to a more oral-like transcriptomic state by expressing canonical activated keratinocyte and oral genes that were direct transcriptional targets of PITX1 as verified by CUT&Tag-Seq.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	The intracellular GSH level was assessed in parental PDAC cells and MRTX1133-resistant PDAC cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "intracellular", "GSH", "level", "was", "assessed", "...
PMC11694625	Although no nitrosating agents or nitrates are used in the synthesis process, the carcinogenic risks of NDEA and NDMA are extremely high.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Althoug...
PMC11469524	B cell receptor signaling represents a network for which the extend of feedback and crosstalk still remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "cell", "receptor", "signaling", "...
PMC8409415	E, In A2780 xenograft mice treated with PBS, the mice were euthanized on day 16 due to the excessive tumor size.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	NGS was performed on 200 ng genomic DNA extracted from peripheral blood at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NGS", "was", "performed", "on", "200", "ng", "genomic", "DNA", ...
PMC11798926	Mouse cultures were transfected with the indicated plasmids using the same protocol at DIV9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "cultures", "were", "transfected", "with", "the", "indicated",...
PMC11461874	To assess the role of TRAF7 on the clock oscillation, we performed its gain- and loss-of-function experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "role", "of", ...
PMC11635519	We then superimposed the PepA3 structure onto the Cryo_EM structure of GLP-1R bound to GLP-1 to build the 3D structure of GLP-1R in a complex with PepA3 (Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	For the intracranial tumor model, 6-week-old female athymic nude mice were stereotactically inoculated in the right hemisphere of the mouse brain (2.0 mm posterior to lambda, 1.5 mm lateral to midline, and 3.0 mm depth from skull) with BT-12 cells (0.25×10 cells/mouse).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	Together, these results suggest that co-treatment of LOS with PFD had the most pronounced effect on BLM-induced EMT in A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Together"...
PMC11129910	Ethnicity was classified into Caucasians, African Americans, and others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ethnicity", "was", "classified", "into", "Caucasians", ",", "African", "Americans", ",", ...
PMC10170482	Activation of the proapoptotic effectors Bcl-2-like protein 4 (BAX) and Bcl-2 homologous antagonist/killer (BAK) protein leads to the disruption of the mitochondrial membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411004	4The relative mRNA expression levels of antibody HC (a) and LC (b) were detected in CHO-ADM cells treated with DMSO or 2 μM I-4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11489351	These controls show that the increases in Notch1 reporter fluorescence observed at high pHi require active gamma-secretase and are thus Notch1-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "controls", ...
PMC11786767	Here, we have applied a super-resolution fluorescence imaging system, that is, TT-ExM (33, 36), to reveal the dynamic distribution of nuclear lipids during the cell cycle, showcasing the involvement of nuclear lipids in how Ki-67 acts in chromosome individualization and segregation during mitosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	Transient transgenic reporter assays for enhancer candidates near human PPL and zebrafish ppl. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transient", "transgenic", "reporter", "assays", "for", "enhancer", "ca...
PMC11762280	The scale bar in black is 100 μm for 10× magnification in D and E. The scale bar in yellow is 20 μm for 40× magnification in D. P < 0.05. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10142392	Increasing the hydrophobic polymer length could decrease the CMC, which can highly enhance drug solubilization and loading capacity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increasing", "the", "hydrophobic", ...
PMC11347429	For the DEGs of non-ICU patients compared to healthy controls, pathways for ‘Defense response to bacterium’, ‘Regulation of viral process’, ‘Response to virus’, ‘Response to biotic stimulus’, and ‘Nuclear division’ were up-regulated genes ( Figure 4A ), and no pathway associations were detected for the down-regulated g...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	Yield: 0.31 g (80%), white solid, m.p: 168–170 °C, Rf.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yield", ":", "0.31", "g", "...
PMC10813895	Because an acceleration of the ELF5 clock is a characteristic of some people at higher-than-average risk for BC, it could be used for early detection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11806613	The indicated triple-positive BC cell line (BT474) and TNBC cell lines [MDA-MB-231 (MB-231), MDA-MB-468 (MB-468), 4T1, and BT549] were treated with increasing doses of OST-01 for 24 h. From left to right: heatmap displaying colony formation, anoikis resistance, wound healing, and invasion levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", ...
PMC11454362	Presentation: 6/3/2024	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Presentation", ":", "6/3/2024" ] } ]
PMC9844987	The number of differentially expressed promoters, split by variability quartiles, after 6 h TNFα treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "differentially", "expresse...
PMC11726848	The cells were washed twice with cold PBS and centrifuged for 5 min at 200× g. Staining was performed using the BD Pharmingen™ Cell Cycle Kit (BD Biosciences, USA) 24, 48, and 72 h after the start of irradiation according to the manufacturer’s protocol, and the cells were analyzed using a CytoFLEX S flow cytometer (Bec...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10568263	The immunosensor in this study exhibits the widest linear detection range among the compared immunosensors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immunosensor", "in", "this", "study", "exhibits", "t...
PMC11279397	Furthermore, comparison of overlapping genes between Perilla frutescens and diseases associated with viral infections showed that 90% of the top 20 enriched terms aligned with the KEGG results obtained for total drug predicted targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	23 libraries (Supplementary file 1) underwent a second round of size selection (Invitrogen E-Gel) to remove excessive primer dimers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "23", ...
PMC10956161	Analysis of the diagnostic value of PRDX6 for lung adenocarcinoma demonstrated that it had poor diagnostic efficacy; and this was also the case for patients with different demographic characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In two patients, a membrane protein defect was suggested by SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "two", "patients", ",", "a", "membrane", "protein", "defect", "was", ...
PMC7192625	We find histone modifications to have similar assortativity patterns in haematopoietic human cells to the ones described in mESCs (25).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "find",...
PMC9587298	Cristina Barros: Formal analysis, Investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cristina", "Barros", ":", "Formal", "analysis", ",", "Investigation", "." ] } ]
PMC10135767	The membrane was blocked for 1 h with 5% skim milk before being incubated overnight at 4 °C with the primary antibodies against anti-Kindlin-3 (1:500; Solarbio, Beijing, China) or anti-β-actin (1:1000; CST, Danvers, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	Using a 10-fold cross-validation strategy, MOSA’s reconstructed hold-out folds for CRISPR-Cas9 and drug responses were robustly correlated with the original data (mean feature Pearson’s r of 0.35 and 0.65, respectively) (Fig. 2a, Supplementary Fig. 3, Supplementary Data 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730311	Datapoints represent technical replicates from a single independent experiment (n = 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Datapoints", "represent", "technical", "replicates", "from", "a", "sin...
PMC11746942	Treatment of HaCaT keratinocytes with increasing concentrations of IL-6 or IL-22, known activators of STAT3, led to a dose-dependent increase in S1PR3 expression (Fig. 6A).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	Nevertheless, there was a marked increase in signal in the striatum at 4 and then at 24 h p. i., with a slightly higher accumulation in the hemisphere associated with the inflammation (Figure 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	LTD, Hyderabad, India; Novartis Pharmaceuticals Corporation, East Hanover, United States of America; Novartis Farma SPA, Lombardy, Italy; Novartis Pharma AG, Basel, Switzerland; Fred Hutchinson Cancer Research Center, Seattle, United States of America; Department of Hematology, Hokkaido University Faculty of Medicine, ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637820	The increase in zone of inactivation was dose- dependent as seen at a maximum of 2 min exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", "in", "zone", "of", ...
PMC9368503	We therefore assessed the effect of doxorubicin on ICR-SS-1 compared to SYO-1 and HS-SY-II.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "We", "therefore", "assessed", "the", "effect", "of", ...
PMC10093184	A recent study has shown its applicability for differential diagnosis between osteosarcoma and other malignant bone tumors, with strong expression in various types of osteosarcomas .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	G. Ruan, J. Abeykoon, A. Hazim, A. Ravindran, K. Rech, J. Young, C. Cox, J. Ryu, M. Koster, O. Tobin, M. Shah, N. Bennani, R. Vassallo, G. Goyal, R. Go Hematology; Internal Medicine; Laboratory Medicine and Pathology; Radiology; Pulmonology; Rheumatology; Neurology, Mayo Clinic Rochester, Rochester; Hematology, Univers...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The ratio of patients who achieved CR and MRD-negative in the RAD group was lower than those in the PAD group (P=0.047 and 0.016, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10502403	The basal OCR/basal ECAR ratio was calculated using the equation: (pmol/min)/(mpH/min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "basal", "OCR/basal", "ECAR", "ratio", "was", "calculated", "using", ...
PMC11680578	JC-1 is a positively charged fluorescent dye that is utilized to pinpoint the physiological state of mitochondria within the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "JC-1", "is", "a", "pos...
PMC11281366	Acquired data were analyzed with FlowJo 10.9 software (BD Biosciences).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acquired", "data", "were", "analyzed", "with", "FlowJo", "10.9", "software", "("...
PMC9776316	While highly effective at the initial stage of treatment, platinum-based chemotherapy mostly encounters severe drug resistance in ovarian cancer patients at a later stage, which leads to tumor recurrence and patient death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222726	B. arida (synonyms: Elaphrium aridum Rose and Terebinthus arida Rose) is endemic in the states of Oaxaca and Puebla .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B.", "arida"...
PMC8777939	Moreover, Western blot analysis indicated that VEGF-A expression was also reduced after etravirine treatment (Figure 4c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "Western", "blot"...
PMC10976516	OVs expressing heat shock proteins (HSPs) are an alternative strategy to boost anti-tumoral immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OVs", "expressing", "heat", "shock", "proteins", ...
PMC11786156	Survival analysis did not show a significant difference in disease-specific survival between the double-positive cases and the non-double-positive cases (P = 0.514, log-rank test) (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A modified toxicity probability interval-2 design is used to evaluate the planned dose levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "modified", "toxicity", "probability", "interval-2", "design", "is...
PMC11218145	administration of TB will need careful studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "administration", "of", "TB", "will", "need", "careful", "studies", "." ] } ]
PMC10114490	GO analysis was performed in Gene Ontology AmiGO (https://amigo.geneontology.org/amigo) using the Bonferroni correction for multiple testing and a FDR < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", ...
PMC8984067	UV-Vis absorption spectra for this solution were determined using UV-Vis spectrophotometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UV-Vis", "absorption", "spectra", "for", "this", "solution", "were", "determined", "using",...
PMC9429973	In vivo BM homing properties and anti-AML efficacy were also analyzed in the AML mice model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "BM", "homing", "properties", "and", ...
PMC7090062	a Results of Luciferase reporter gene assays. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Results", "of", "Luciferase", "reporter", "gene", "assays", ".", "", "", "*" ] ...
PMC7039683	For comparison, ATAC-seq on GFP-positive and GFP-negative cells sorted from Tg(fli1:gfp) zebrafish embryos at 24 hpf (Quillien et al., 2017), or pro-sensory cells sorted from cochlear ducts in sox2-EGFP transgenic mice (Wilkerson et al., 2019), revealed about 9% and 15%, respectively, of all ATAC-seq elements to have g...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757230	The animal study protocol was approved by the Bioethics Committee of Nippon Veterinary and Life Science University (approval number 2021S-40; September 8, 2021 and 2024S-25; July 26, 2024).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11024707	It was shown that mi-RNA-146a is expressed in regions that are important for higher cognitive and social functions, such as the frontal cortex, amygdala, and hippocampus at the postnatal stage, and that overexpression of mi-RNA-146a stimulates neuronal differentiation and alters dendritic branching .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	A–D) Apoptosis of CLP36-silencing lymphoma cells BJAB (A, B) and RA 1 (C, D), as quantified based on the flow cytometry assay. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O"...
PMC11635087	Although the exchange of substances between incorporated chloroplasts and nuclei or mitochondria remains undetermined, certain pathways and processes may be active, including the retrograde signaling pathway, which sends small molecular signals from chloroplasts to the nucleus, or redox transport via malate from chloro...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519	When a peptide activates a receptor, cAMP levels increase intracellularly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "a", "peptide", "activates", "a", "receptor", ",", "cAMP", "levels", "increase...
PMC10812665	Cells in these were treated in the NeuriTox assay with the test compounds for 24 h. The control samples were treated with 0.1% dimethyl sulfoxide (DMSO, Merck, Darmstadt, Germany) for 24 h. To facilitate the interpretation of our findings, we provide detailed descriptions of the selected toxicants in Supplementary Figu...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732635	On September 7, 2022, he received an intravenous infusion of CAR T cells (4×10/kg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "September", "7", ...
PMC11047729	The ATRA’s influence on the DNA is displayed in Figure 6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ATRA", "’s", "influence", "on", "the", "DNA", "is", "displayed", "i...
PMC11755467	hsa-miR-150-5p TaqMan™ probe (ThermoFisher: # 4427975-000473) hsa-miR-223-3p TaqMan™ probe (ThermoFisher: # 4427975-002098) hsa-miR-29a-3p TaqMan™ probe (ThermoFisher: # 4427975-002112) hsa-miR-125b-5p TaqMan™ probe (ThermoFisher: # 442797-000449) hsa-miR-142-3p TaqMan™ probe (ThermoFisher: # 442797-000464) hsa-miR-23a...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10454535	Apoptosis induction in MM cells was assessed due to increased sensitivity of cancer cells to apoptosis-targeting treatments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "induction", "in", "MM", "cells", ...
PMC10040136	Several studies have suggested that primary TKI resistance, defined as progression within the first 6 months of therapy, may be attributed to PDGFRA p.D842V substitution or KIT exon 9 duplications .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	Cells were transfected with indicated siRNAs for 96 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "transfected", "with", "indicated", "siRNAs", "for", "96", "hours", "." ] } ]
PMC11637276	Cells were then washed thrice with PBS and incubated with the secondary antibody Alexa Fluor 488 Donkey Anti-mouse (1:1,000) for 45 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11122631	Most of the compounds were predicted to show cytotoxicity for two tumor cell lines (A2780cisR and PC-3) (Table 1), but compound 2 was predicted to only show cytotoxicity for A2780cisR, and compound 8 was predicted to show cytotoxicity for PC-3, HT-29, and A2780cisR. A2780cisR is the cisplatin-resistant human ovarian ca...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301242	The Hi-C matrix was aggregated and normalized using Cooler, after which the output mcool files were utilized for predicting structural variations (SVs) with EagleC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767582

C NMR (75 MHz, CDCl3) δ 153.7, 138.9, 136.7, 135.7, 133.5, 132.0, 129.9, 129.4, 125.4, 103.0, 61.2, 56.4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11711127

In this review we aim to define these boarders by providing new perspectives to long-standing theories of tolerance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "review", "we", "aim", ...

PMC3734024

p<0.01.

[ { "tags": [ "O", "O" ], "tokens": [ "p<0.01", "." ] } ]

PMC10589262

One-way ANOVA with a post-hoc test was performed to compare multiple means (*p < 0.05, **p < 0.01, ***p < 0.001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11473750

Parent mouse 1929, that did not develop a tumour, is shown as a comparison.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parent", "mouse", "1929", ",", "that", "did", "n...

PMC11746948

After that, the gel was incubated with destaining buffer (50% CH3OH, 40% water, and 10% acetic acid) by shaking for 2–8 h and then incubated in water to help lower the background.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612315

The cells were then rinsed three times with the medium and incubated for 30 min, after which they were placed on the stage of an inverted microscope (BX51W1; Olympus, Tokyo, Japan) and continuously superfused at a flow speed of 1 mL/min with a bath solution containing 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 2 mM MgCl2, 10 m...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754784

These results demonstrate that the DNP1 can accurately identify target cells through a three-layer two-input Boolean operation, in which both aptamer and Nb-based molecular recognitions are involved into the molecular computation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9910796

A DNA library was generated using 500 ng of purified viral DNA with the DNA Prep Tagmentation (Illumina) kit and the Illumina DNA/RNA UD Indexes Set A(IDT) adapters, following the manufacturer’s instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11332076

Takayuki Harada: Writing – review & editing, Writing – original draft, Project administration, Funding acquisition.

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PMC11413393

All ‘epiprobe’ compounds were purchased from Cayman Chemical, Millipore-Sigma or MedChemExpress.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "‘", "epiprobe", "’", "compounds", "were", "purchased", "f...

PMC11209164

While our study included only a limited number of patient specimens, the observation of substantial activity of TPF with oncolytic VSVΔ51 in human pancreatic and ovarian cancer tumor explants (Figure 3E) offers choice areas for further pre-clinical exploration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11763126

The function of YTHDF2 in ccRCC remains uncertain.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "function", "of", "YTHDF2", "in", "ccRCC", "remains", "uncertain", "." ] } ]

PMC11472569

These EVs can alter the transcriptional environment of recipient cells, thereby reflecting the donor MDR phenotype.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "EVs", "can", "alter", "the", "tran...

PMC10568263

The MnO2 nanoflowers were synthesized by dissolving 0.53 g MnSO4 and 1.33 g KMnO4 in 40 mL of DI water.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MnO2", "nanoflowers",...

PMC5941560

Long deletions and duplications from Jurkat were also found in ClinVar, but the annotations do not contain gene information and are generally less informative (Additional files 2 and 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11461874

A heterodimer of CLOCK and BMAL1 binds to E-box DNA sequences (CACGTG and its related sequences) to activate transcription of thousands of genes including Per and Cry.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11790599

Cotreatment with ML385 markedly abrogated macropinosomes formation (Figure 5B) and the cell death induced by TSL (Figure 5C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cotreatment", ...

PMC11678130

A well-known phytocompound with a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antihypertensive, vasodilatory, antiatherosclerotic, antiangiogenic, and antineoplastic properties, is quercetin (QUE), a flavonoid that is widely distributed in apples, berries, grapes, onions, tomatoes...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740508

These patients were not selected for HR mutations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "patients", "were", "not", "selected", "for", "HR", "mutations", "." ] } ]

PMC11634027

Wing hair polarity angles were plotted as a Rose plot using MATLAB (MathWorks).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wing", "hair", "polarity", "angles", "were", "plotted", "as...

PMC11024707

Mi-RNA-28-3p was shown to target various cancer-related genes and is a mi-RNA potentially involved in cell proliferation and migration .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mi-RNA-28", "-", ...

PMC10538569

Every 3 days, 1.2 ml culture supernatants were collected and replaced with fresh complete RPMI 1640 medium.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "3", "days", ",", "1.2", ...

PMC11609529

VPF (T3112) and CA3 (T4309) were purchased from TargetMol.

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PMC10291556

Condition of analyses: RP HPLC: gradient 0–100% B in 15 min (A = 0.1% TFA, B = ACN).

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PMC11529598

Our results demonstrated that miR-3154 was significantly up-regulated in glioblastoma tissues.

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PMC11665584

Subpopulations of skin keratinocytes from PITX1 mice were shifted to a more oral-like transcriptomic state by expressing canonical activated keratinocyte and oral genes that were direct transcriptional targets of PITX1 as verified by CUT&Tag-Seq.

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PMC11536589

The intracellular GSH level was assessed in parental PDAC cells and MRTX1133-resistant PDAC cells. (

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PMC11694625

Although no nitrosating agents or nitrates are used in the synthesis process, the carcinogenic risks of NDEA and NDMA are extremely high.

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PMC11469524

B cell receptor signaling represents a network for which the extend of feedback and crosstalk still remains unclear.

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PMC8409415

E, In A2780 xenograft mice treated with PBS, the mice were euthanized on day 16 due to the excessive tumor size.

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PMC9429973

NGS was performed on 200 ng genomic DNA extracted from peripheral blood at diagnosis.

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PMC11798926

Mouse cultures were transfected with the indicated plasmids using the same protocol at DIV9.

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PMC11461874

To assess the role of TRAF7 on the clock oscillation, we performed its gain- and loss-of-function experiments.

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PMC11635519

We then superimposed the PepA3 structure onto the Cryo_EM structure of GLP-1R bound to GLP-1 to build the 3D structure of GLP-1R in a complex with PepA3 (Figure 5A).

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PMC11185260

For the intracranial tumor model, 6-week-old female athymic nude mice were stereotactically inoculated in the right hemisphere of the mouse brain (2.0 mm posterior to lambda, 1.5 mm lateral to midline, and 3.0 mm depth from skull) with BT-12 cells (0.25×10 cells/mouse).

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PMC10329237

Together, these results suggest that co-treatment of LOS with PFD had the most pronounced effect on BLM-induced EMT in A549 cells.

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PMC11129910

Ethnicity was classified into Caucasians, African Americans, and others.

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PMC10170482

Activation of the proapoptotic effectors Bcl-2-like protein 4 (BAX) and Bcl-2 homologous antagonist/killer (BAK) protein leads to the disruption of the mitochondrial membrane.

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PMC11411004

4The relative mRNA expression levels of antibody HC (a) and LC (b) were detected in CHO-ADM cells treated with DMSO or 2 μM I-4.

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PMC11489351

These controls show that the increases in Notch1 reporter fluorescence observed at high pHi require active gamma-secretase and are thus Notch1-dependent.

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PMC11786767

Here, we have applied a super-resolution fluorescence imaging system, that is, TT-ExM (33, 36), to reveal the dynamic distribution of nuclear lipids during the cell cycle, showcasing the involvement of nuclear lipids in how Ki-67 acts in chromosome individualization and segregation during mitosis.

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PMC7039683

Transient transgenic reporter assays for enhancer candidates near human PPL and zebrafish ppl. (

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PMC11762280

The scale bar in black is 100 μm for 10× magnification in D and E. The scale bar in yellow is 20 μm for 40× magnification in D. *P < 0.05. **

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PMC10142392

Increasing the hydrophobic polymer length could decrease the CMC, which can highly enhance drug solubilization and loading capacity .

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PMC11347429

For the DEGs of non-ICU patients compared to healthy controls, pathways for ‘Defense response to bacterium’, ‘Regulation of viral process’, ‘Response to virus’, ‘Response to biotic stimulus’, and ‘Nuclear division’ were up-regulated genes ( Figure 4A ), and no pathway associations were detected for the down-regulated g...

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PMC11618052

Yield: 0.31 g (80%), white solid, m.p: 168–170 °C, Rf.

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PMC10813895

Because an acceleration of the ELF5 clock is a characteristic of some people at higher-than-average risk for BC, it could be used for early detection.

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PMC11806613

The indicated triple-positive BC cell line (BT474) and TNBC cell lines [MDA-MB-231 (MB-231), MDA-MB-468 (MB-468), 4T1, and BT549] were treated with increasing doses of OST-01 for 24 h. From left to right: heatmap displaying colony formation, anoikis resistance, wound healing, and invasion levels.

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PMC11454362

Presentation: 6/3/2024

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PMC9844987

The number of differentially expressed promoters, split by variability quartiles, after 6 h TNFα treatment.

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PMC11726848

The cells were washed twice with cold PBS and centrifuged for 5 min at 200× g. Staining was performed using the BD Pharmingen™ Cell Cycle Kit (BD Biosciences, USA) 24, 48, and 72 h after the start of irradiation according to the manufacturer’s protocol, and the cells were analyzed using a CytoFLEX S flow cytometer (Bec...

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PMC10568263

The immunosensor in this study exhibits the widest linear detection range among the compared immunosensors.

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PMC11279397

Furthermore, comparison of overlapping genes between Perilla frutescens and diseases associated with viral infections showed that 90% of the top 20 enriched terms aligned with the KEGG results obtained for total drug predicted targets.

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PMC9844987

23 libraries (Supplementary file 1) underwent a second round of size selection (Invitrogen E-Gel) to remove excessive primer dimers.

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PMC10956161

Analysis of the diagnostic value of PRDX6 for lung adenocarcinoma demonstrated that it had poor diagnostic efficacy; and this was also the case for patients with different demographic characteristics.

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PMC9429973

In two patients, a membrane protein defect was suggested by SDS-PAGE.

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PMC7192625

We find histone modifications to have similar assortativity patterns in haematopoietic human cells to the ones described in mESCs (25).

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PMC9587298

Cristina Barros: Formal analysis, Investigation.

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PMC10135767

The membrane was blocked for 1 h with 5% skim milk before being incubated overnight at 4 °C with the primary antibodies against anti-Kindlin-3 (1:500; Solarbio, Beijing, China) or anti-β-actin (1:1000; CST, Danvers, MA, USA).

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PMC11607321

Using a 10-fold cross-validation strategy, MOSA’s reconstructed hold-out folds for CRISPR-Cas9 and drug responses were robustly correlated with the original data (mean feature Pearson’s r of 0.35 and 0.65, respectively) (Fig. 2a, Supplementary Fig. 3, Supplementary Data 5).

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PMC11730311

Datapoints represent technical replicates from a single independent experiment (n = 1).

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PMC11746942

Treatment of HaCaT keratinocytes with increasing concentrations of IL-6 or IL-22, known activators of STAT3, led to a dose-dependent increase in S1PR3 expression (Fig. 6A).

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PMC11604830

Nevertheless, there was a marked increase in signal in the striatum at 4 and then at 24 h p. i., with a slightly higher accumulation in the hemisphere associated with the inflammation (Figure 6D).

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PMC9429973

LTD, Hyderabad, India; Novartis Pharmaceuticals Corporation, East Hanover, United States of America; Novartis Farma SPA, Lombardy, Italy; Novartis Pharma AG, Basel, Switzerland; Fred Hutchinson Cancer Research Center, Seattle, United States of America; Department of Hematology, Hokkaido University Faculty of Medicine, ...

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PMC11637820

The increase in zone of inactivation was dose- dependent as seen at a maximum of 2 min exposure.

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PMC9368503

We therefore assessed the effect of doxorubicin on ICR-SS-1 compared to SYO-1 and HS-SY-II.

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PMC10093184

A recent study has shown its applicability for differential diagnosis between osteosarcoma and other malignant bone tumors, with strong expression in various types of osteosarcomas .

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PMC9429973

G. Ruan, J. Abeykoon, A. Hazim, A. Ravindran, K. Rech, J. Young, C. Cox, J. Ryu, M. Koster, O. Tobin, M. Shah, N. Bennani, R. Vassallo, G. Goyal, R. Go Hematology; Internal Medicine; Laboratory Medicine and Pathology; Radiology; Pulmonology; Rheumatology; Neurology, Mayo Clinic Rochester, Rochester; Hematology, Univers...

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PMC9429973

The ratio of patients who achieved CR and MRD-negative in the RAD group was lower than those in the PAD group (P=0.047 and 0.016, respectively).

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PMC10502403

The basal OCR/basal ECAR ratio was calculated using the equation: (pmol/min)/(mpH/min).

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PMC11680578

JC-1 is a positively charged fluorescent dye that is utilized to pinpoint the physiological state of mitochondria within the cells.

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PMC11281366

Acquired data were analyzed with FlowJo 10.9 software (BD Biosciences).

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PMC9776316

While highly effective at the initial stage of treatment, platinum-based chemotherapy mostly encounters severe drug resistance in ovarian cancer patients at a later stage, which leads to tumor recurrence and patient death .

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PMC6222726

B. arida (synonyms: Elaphrium aridum Rose and Terebinthus arida Rose) is endemic in the states of Oaxaca and Puebla .

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PMC8777939

Moreover, Western blot analysis indicated that VEGF-A expression was also reduced after etravirine treatment (Figure 4c).

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PMC10976516

OVs expressing heat shock proteins (HSPs) are an alternative strategy to boost anti-tumoral immune responses.

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PMC11786156

Survival analysis did not show a significant difference in disease-specific survival between the double-positive cases and the non-double-positive cases (P = 0.514, log-rank test) (Figure 2).

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PMC9429973

A modified toxicity probability interval-2 design is used to evaluate the planned dose levels.

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PMC11218145

administration of TB will need careful studies.

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PMC10114490

GO analysis was performed in Gene Ontology AmiGO (https://amigo.geneontology.org/amigo) using the Bonferroni correction for multiple testing and a FDR < 0.05.

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PMC8984067

UV-Vis absorption spectra for this solution were determined using UV-Vis spectrophotometry.

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PMC9429973

In vivo BM homing properties and anti-AML efficacy were also analyzed in the AML mice model.

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PMC7090062

a Results of Luciferase reporter gene assays. ***

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PMC7039683

For comparison, ATAC-seq on GFP-positive and GFP-negative cells sorted from Tg(fli1:gfp) zebrafish embryos at 24 hpf (Quillien et al., 2017), or pro-sensory cells sorted from cochlear ducts in sox2-EGFP transgenic mice (Wilkerson et al., 2019), revealed about 9% and 15%, respectively, of all ATAC-seq elements to have g...

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PMC11757230

The animal study protocol was approved by the Bioethics Committee of Nippon Veterinary and Life Science University (approval number 2021S-40; September 8, 2021 and 2024S-25; July 26, 2024).

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PMC11024707

It was shown that mi-RNA-146a is expressed in regions that are important for higher cognitive and social functions, such as the frontal cortex, amygdala, and hippocampus at the postnatal stage, and that overexpression of mi-RNA-146a stimulates neuronal differentiation and alters dendritic branching .

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PMC11674146

A–D) Apoptosis of CLP36-silencing lymphoma cells BJAB (A, B) and RA 1 (C, D), as quantified based on the flow cytometry assay. (

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PMC11635087

Although the exchange of substances between incorporated chloroplasts and nuclei or mitochondria remains undetermined, certain pathways and processes may be active, including the retrograde signaling pathway, which sends small molecular signals from chloroplasts to the nucleus, or redox transport via malate from chloro...

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PMC11635519

When a peptide activates a receptor, cAMP levels increase intracellularly.

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PMC10812665

Cells in these were treated in the NeuriTox assay with the test compounds for 24 h. The control samples were treated with 0.1% dimethyl sulfoxide (DMSO, Merck, Darmstadt, Germany) for 24 h. To facilitate the interpretation of our findings, we provide detailed descriptions of the selected toxicants in Supplementary Figu...

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PMC11732635

On September 7, 2022, he received an intravenous infusion of CAR T cells (4×10/kg).

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PMC11047729

The ATRA’s influence on the DNA is displayed in Figure 6.

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PMC11755467

hsa-miR-150-5p TaqMan™ probe (ThermoFisher: # 4427975-000473) hsa-miR-223-3p TaqMan™ probe (ThermoFisher: # 4427975-002098) hsa-miR-29a-3p TaqMan™ probe (ThermoFisher: # 4427975-002112) hsa-miR-125b-5p TaqMan™ probe (ThermoFisher: # 442797-000449) hsa-miR-142-3p TaqMan™ probe (ThermoFisher: # 442797-000464) hsa-miR-23a...

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PMC10454535

Apoptosis induction in MM cells was assessed due to increased sensitivity of cancer cells to apoptosis-targeting treatments .

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PMC10040136

Several studies have suggested that primary TKI resistance, defined as progression within the first 6 months of therapy, may be attributed to PDGFRA p.D842V substitution or KIT exon 9 duplications .

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PMC11701801

Cells were transfected with indicated siRNAs for 96 hours.

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PMC11637276

Cells were then washed thrice with PBS and incubated with the secondary antibody Alexa Fluor 488 Donkey Anti-mouse (1:1,000) for 45 min at room temperature.

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PMC11122631

Most of the compounds were predicted to show cytotoxicity for two tumor cell lines (A2780cisR and PC-3) (Table 1), but compound 2 was predicted to only show cytotoxicity for A2780cisR, and compound 8 was predicted to show cytotoxicity for PC-3, HT-29, and A2780cisR. A2780cisR is the cisplatin-resistant human ovarian ca...

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PMC11301242

The Hi-C matrix was aggregated and normalized using Cooler, after which the output mcool files were utilized for predicting structural variations (SVs) with EagleC .

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