OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11577421	Next, we compared NP uptake between untreated and enzyme-treated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "compared", "NP", "uptake", "between", "untreated", "and", "enzyme-treated", "cells", "." ] } ]
PMC11640555	The amount of MTT reduced to formazan was quantified by measuring the optical density at 540 nm (OD540) with a microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amount", "of", "MTT", "reduced", "to", "formazan", "was", "quantified", "by", "measuring", "the", "optical", "density", "at", "540", "nm", "(", "OD540", ")", "with", "a", "microplate", "reader", "." ] } ]
PMC11756937	In general, for freezing, the cells were dissociated enzymatically, and the detached cell aggregates were centrifuged at 1100 rpm for 3 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "for", "freezing", ",", "the", "cells", "were", "dissociated", "enzymatically", ",", "and", "the", "detached", "cell", "aggregates", "were", "centrifuged", "at", "1100", "rpm", "for", "3", "min", "at", "room", "temperature", "." ] } ]
PMC6934009	Apoptosis, a complex process associated with the elimination of unwanted cells from the body, is controlled by several genes (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", ",", "a", "complex", "process", "associated", "with", "the", "elimination", "of", "unwanted", "cells", "from", "the", "body", ",", "is", "controlled", "by", "several", "genes", "(", "12", ")", "." ] } ]
PMC6133382	Underlaying data can be found in S2 Data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Underlaying", "data", "can", "be", "found", "in", "S2", "Data", "." ] } ]
PMC11200978	The American Cancer Society reports about 1 in 5 cancer-related deaths to be caused by LC, resulting in more deaths than colon, breast, and prostate cancer combined .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "American", "Cancer", "Society", "reports", "about", "1", "in", "5", "cancer-related", "deaths", "to", "be", "caused", "by", "LC", ",", "resulting", "in", "more", "deaths", "than", "colon", ",", "breast", ",", "and", "prostate", "cancer", "combined", "." ] } ]
PMC11755467	Raw sequencing reads were aligned with the target reference sequence -pre-miR-hsa-132-, and experimental conditions were defined-modified, untreated, and denatured samples for comparative analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Raw", "sequencing", "reads", "were", "aligned", "with", "the", "target", "reference", "sequence", "-pre-miR-hsa-132-", ",", "and", "experimental", "conditions", "were", "defined-modified", ",", "untreated", ",", "and", "denatured", "samples", "for", "comparative", "analysis", "." ] } ]
PMC5574817	Chemiluminescence signal was analyzed using ChemiDoc XRS Imaging System (BioRad Laboratories, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemiluminescence", "signal", "was", "analyzed", "using", "ChemiDoc", "XRS", "Imaging", "System", "(", "BioRad", "Laboratories", ",", "USA", ")", "." ] } ]
PMC9739791	Without the reducing agent in the dark, the degradation of the Pt(IV) prodrug 27 was negligible, while in the presence of 5 equivalents of ascorbic acid the complex showed a 50% reduction within 24 h of incubation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Without", "the", "reducing", "agent", "in", "the", "dark", ",", "the", "degradation", "of", "the", "Pt(IV", ")", "prodrug", "27", "was", "negligible", ",", "while", "in", "the", "presence", "of", "5", "equivalents", "of", "ascorbic", "acid", "the", "complex", "showed", "a", "50", "%", "reduction", "within", "24", "h", "of", "incubation", "." ] } ]
PMC9429973	Vascular comorbidities were seen in 22 (50%) patients, the most frequent being hypertension (n=12, 27%), peripheral vascular disease (n=6, 14%), AF (n=6, 14%) and ischaemic heart disease (n=6, 14%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vascular", "comorbidities", "were", "seen", "in", "22", "(", "50", "%", ")", "patients", ",", "the", "most", "frequent", "being", "hypertension", "(", "n=12", ",", "27", "%", ")", ",", "peripheral", "vascular", "disease", "(", "n=6", ",", "14", "%", ")", ",", "AF", "(", "n=6", ",", "14", "%", ")", "and", "ischaemic", "heart", "disease", "(", "n=6", ",", "14", "%", ")", "." ] } ]
PMC10778532	Sunitinib treatment also conferred a more mesenchymal profile to VHL-C162F cells with significant downregulation of E-cadherin and upregulation of N-cadherin, Slug and AXL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sunitinib", "treatment", "also", "conferred", "a", "more", "mesenchymal", "profile", "to", "VHL-C162F", "cells", "with", "significant", "downregulation", "of", "E-cadherin", "and", "upregulation", "of", "N-cadherin", ",", "Slug", "and", "AXL", "." ] } ]
PMC11592837	Similar to the DII of MTCO3, the DII of Alu in the control PBMCs rose over time; however, mean values were considerably lower, starting with 0.32 and reaching a maximum of 0.82 after 8 h (Figure 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "to", "the", "DII", "of", "MTCO3", ",", "the", "DII", "of", "Alu", "in", "the", "control", "PBMCs", "rose", "over", "time", ";", "however", ",", "mean", "values", "were", "considerably", "lower", ",", "starting", "with", "0.32", "and", "reaching", "a", "maximum", "of", "0.82", "after", "8", "h", "(", "Figure", "7B", ")", "." ] } ]
PMC10093184	Bone is the only connective tissue producing ALPL in dogs and it can therefore be used to differentiate the canine osteosarcoma from other vimentin-positive tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bone", "is", "the", "only", "connective", "tissue", "producing", "ALPL", "in", "dogs", "and", "it", "can", "therefore", "be", "used", "to", "differentiate", "the", "canine", "osteosarcoma", "from", "other", "vimentin-positive", "tumors", "." ] } ]
PMC10197932	For Eryptosis assay, RBCs untreated and treated were resuspended in 200 μl of 1X Annexin Buffer plus 10 μl Annexin-V Alexa Fluor, then spun down at 800 x g 10 min washed with PBS + 0.1 % BSA and analyzed by Flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "Eryptosis", "assay", ",", "RBCs", "untreated", "and", "treated", "were", "resuspended", "in", "200", "μl", "of", "1X", "Annexin", "Buffer", "plus", "10", "μl", "Annexin-V", "Alexa", "Fluor", ",", "then", "spun", "down", "at", "800", "x", "g", "10", "min", "washed", "with", "PBS", "+", "0.1", "%", "BSA", "and", "analyzed", "by", "Flow", "cytometry", "." ] } ]
PMC11577421	Cytotoxicity in HeLa cells exposed to PCX-loaded NPs. (	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "in", "HeLa", "cells", "exposed", "to", "PCX-loaded", "NPs", ".", "(" ] } ]
PMC11754094	Identifying the repair pathways that produce large deletions following genome editing with Cas9 or nCas9 will not only provide key insight into the biology of this process but also enable the development of strategies to mitigate large-deletion events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identifying", "the", "repair", "pathways", "that", "produce", "large", "deletions", "following", "genome", "editing", "with", "Cas9", "or", "nCas9", "will", "not", "only", "provide", "key", "insight", "into", "the", "biology", "of", "this", "process", "but", "also", "enable", "the", "development", "of", "strategies", "to", "mitigate", "large-deletion", "events", "." ] } ]
PMC11721295	Fisher et al. showed that at 17–25 weeks, mice develop a measurable tumor burden, thus providing rationale for our analyses (8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fisher", "et", "al.", "showed", "that", "at", "17–25", "weeks", ",", "mice", "develop", "a", "measurable", "tumor", "burden", ",", "thus", "providing", "rationale", "for", "our", "analyses", "(", "8)", "." ] } ]
PMC9516447	The homogenized lysates were incubated on ice for 30 minutes followed by centrifugation at 13,000 RPM for 15 minutes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "homogenized", "lysates", "were", "incubated", "on", "ice", "for", "30", "minutes", "followed", "by", "centrifugation", "at", "13,000", "RPM", "for", "15", "minutes", "." ] } ]
PMC10849234	Following introduction of CRISPRi constructs and confirmation that Rab27a transcript levels were reduced (Fig 4A), we differentiated cells using DMSO and G-CSF, and then treated them with Cytochalasin B and fMLP to induce degranulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "introduction", "of", "CRISPRi", "constructs", "and", "confirmation", "that", "Rab27a", "transcript", "levels", "were", "reduced", "(", "Fig", "4A", ")", ",", "we", "differentiated", "cells", "using", "DMSO", "and", "G-CSF", ",", "and", "then", "treated", "them", "with", "Cytochalasin", "B", "and", "fMLP", "to", "induce", "degranulation", "." ] } ]
PMC11633763	Based on these studies, it can be concluded that tumour cells prefer glycolysis to oxidative phosphorylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "studies", ",", "it", "can", "be", "concluded", "that", "tumour", "cells", "prefer", "glycolysis", "to", "oxidative", "phosphorylation", "." ] } ]
PMC3765139	The authors declare that they have no competing interests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "declare", "that", "they", "have", "no", "competing", "interests", "." ] } ]
PMC10933092	The sh-TRMT61A oligonucleotide sequences were as follows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sh-TRMT61A", "oligonucleotide", "sequences", "were", "as", "follows", "." ] } ]
PMC10969097	MDR incorporates a variety of mechanisms that give cancer cells a survival advantage against cancer therapies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDR", "incorporates", "a", "variety", "of", "mechanisms", "that", "give", "cancer", "cells", "a", "survival", "advantage", "against", "cancer", "therapies", "." ] } ]
PMC11549062	Increased PTP1B levels disrupted the endo‐lysosomal interaction, resulting in the accumulation of PDGFR‐β and subsequent elevation in apoptosis, thereby fostering plaque vulnerability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increased", "PTP1B", "levels", "disrupted", "the", "endo‐lysosomal", "interaction", ",", "resulting", "in", "the", "accumulation", "of", "PDGFR‐β", "and", "subsequent", "elevation", "in", "apoptosis", ",", "thereby", "fostering", "plaque", "vulnerability", "." ] } ]
PMC11585254	We note that in our experiments, binding between receptor and β-arrestin was measured by BRET, which is dependent upon the close proximity of the donor and acceptor molecules but can also be influenced by their orientation (Hamdan et al., 2006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "note", "that", "in", "our", "experiments", ",", "binding", "between", "receptor", "and", "β-arrestin", "was", "measured", "by", "BRET", ",", "which", "is", "dependent", "upon", "the", "close", "proximity", "of", "the", "donor", "and", "acceptor", "molecules", "but", "can", "also", "be", "influenced", "by", "their", "orientation", "(", "Hamdan", "et", "al.", ",", "2006", ")", "." ] } ]
PMC11737091	Three constructed shRNA sequences targeting DBF4 were used to silence DBF4 expression in ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "constructed", "shRNA", "sequences", "targeting", "DBF4", "were", "used", "to", "silence", "DBF4", "expression", "in", "ccRCC", "." ] } ]
PMC7215722	The DSS-induced ER-stress resulted in impaired intracellular trafficking and polarized sorting of sucrase-isomaltase (SI) and dipeptidyl peptidase-4 (DPPIV), which are normally sorted to the apical membrane via association with lipid rafts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DSS-induced", "ER-stress", "resulted", "in", "impaired", "intracellular", "trafficking", "and", "polarized", "sorting", "of", "sucrase-isomaltase", "(", "SI", ")", "and", "dipeptidyl", "peptidase-4", "(", "DPPIV", ")", ",", "which", "are", "normally", "sorted", "to", "the", "apical", "membrane", "via", "association", "with", "lipid", "rafts", "." ] } ]
PMC11653168	In addition, a significant reduction in tumor weight was detected in the 15 and 30 mg/kg Stattic, and 1 mg/kg DEX treatment groups relative to the control (Fig. 7D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "a", "significant", "reduction", "in", "tumor", "weight", "was", "detected", "in", "the", "15", "and", "30", "mg/kg", "Stattic", ",", "and", "1", "mg/kg", "DEX", "treatment", "groups", "relative", "to", "the", "control", "(", "Fig.", "7D", ")", "." ] } ]
PMC11763111	K Percentage of IL-10 expression in CCRF-CEM pre-incubated CAR-T with DMSO and 20 µ mol JSH-23 (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K", "Percentage", "of", "IL-10", "expression", "in", "CCRF-CEM", "pre-incubated", "CAR-T", "with", "DMSO", "and", "20", "µ", "mol", "JSH-23", "(", "n", "=", "3", ")", "." ] } ]
PMC10571053	One of the first reported inducers of ferroptosis, erastin, was described before the concept of ferroptosis was completely understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "first", "reported", "inducers", "of", "ferroptosis", ",", "erastin", ",", "was", "described", "before", "the", "concept", "of", "ferroptosis", "was", "completely", "understood", "." ] } ]
PMC11347429	However, only some DEGs (169) were statistically significant in the direct contrast between ICU and non-ICU patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "only", "some", "DEGs", "(", "169", ")", "were", "statistically", "significant", "in", "the", "direct", "contrast", "between", "ICU", "and", "non-ICU", "patients", "." ] } ]
PMC7039683	Best match, transcription factor in the indicated family with highest expression in GFP-positive cells, whether or not the expression is enriched in GFP-positive cells in comparison to GFP-negative cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Best", "match", ",", "transcription", "factor", "in", "the", "indicated", "family", "with", "highest", "expression", "in", "GFP-positive", "cells", ",", "whether", "or", "not", "the", "expression", "is", "enriched", "in", "GFP-positive", "cells", "in", "comparison", "to", "GFP-negative", "cells", ".", "(" ] } ]
PMC9429973	After a median follow-up of 13.5 months, ORR for cohort 1 was 73% (95% CI, 54-88; complete response, 7 patients [23%]; partial response, 15 patients [50%]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "median", "follow-up", "of", "13.5", "months", ",", "ORR", "for", "cohort", "1", "was", "73", "%", "(", "95", "%", "CI", ",", "54", "-", "88", ";", "complete", "response", ",", "7", "patients", "[", "23", "%", "]", ";", "partial", "response", ",", "15", "patients", "[", "50", "%", "]", ")", "." ] } ]
PMC11756514	Bacterial aggregation by SP-D. Bacteria incubated with or without SP-D (control) in either calcium or EDTA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bacterial", "aggregation", "by", "SP-D.", "Bacteria", "incubated", "with", "or", "without", "SP-D", "(", "control", ")", "in", "either", "calcium", "or", "EDTA", "." ] } ]
PMC9429973	A bone marrow sample was obtained at diagnosis and when remission was achieved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "bone", "marrow", "sample", "was", "obtained", "at", "diagnosis", "and", "when", "remission", "was", "achieved", "." ] } ]
PMC10440586	Therefore, for patients with gliomas with high expression of CD99, tumor adaptability should be fully considered clinically.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "for", "patients", "with", "gliomas", "with", "high", "expression", "of", "CD99", ",", "tumor", "adaptability", "should", "be", "fully", "considered", "clinically", "." ] } ]
PMC11352877	ANG1 acts as a paracrine agonist on TIE-2, leading to dimerization of the receptor and inducing its phosphorylation, which then activates target signaling molecules, increases the association of endothelial cells with pericytes and vascular smooth muscle cells, and stimulates maturation of the vascular network .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANG1", "acts", "as", "a", "paracrine", "agonist", "on", "TIE-2", ",", "leading", "to", "dimerization", "of", "the", "receptor", "and", "inducing", "its", "phosphorylation", ",", "which", "then", "activates", "target", "signaling", "molecules", ",", "increases", "the", "association", "of", "endothelial", "cells", "with", "pericytes", "and", "vascular", "smooth", "muscle", "cells", ",", "and", "stimulates", "maturation", "of", "the", "vascular", "network", "." ] } ]
PMC11319300	MYEOV is a young protein-coding gene, with an ORF exclusive to primates but the DNA sequence of the MYEOV-3′-putative enhancer region exhibited conservation not only across mammals but also in chicken.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MYEOV", "is", "a", "young", "protein-coding", "gene", ",", "with", "an", "ORF", "exclusive", "to", "primates", "but", "the", "DNA", "sequence", "of", "the", "MYEOV-3′-putative", "enhancer", "region", "exhibited", "conservation", "not", "only", "across", "mammals", "but", "also", "in", "chicken", "." ] } ]
PMC10976516	Moreover, lung cancer patients are often diagnosed between the ages of 60 and 80, with the most frequent occurrence between 65 and 75.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "lung", "cancer", "patients", "are", "often", "diagnosed", "between", "the", "ages", "of", "60", "and", "80", ",", "with", "the", "most", "frequent", "occurrence", "between", "65", "and", "75", "." ] } ]
PMC11774747	Further investigations should focus on directly comparing these costimulatory domains while controlling for confounding variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "investigations", "should", "focus", "on", "directly", "comparing", "these", "costimulatory", "domains", "while", "controlling", "for", "confounding", "variables", "." ] } ]
PMC11078693	Note: For this protocol, we used the commercial Biotium Mix-n-Stain Kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ":", "For", "this", "protocol", ",", "we", "used", "the", "commercial", "Biotium", "Mix-n-Stain", "Kit", "." ] } ]
PMC11224020	Data were analyzed by one-way Mann–Whitney test; ****P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "one-way", "Mann", "–", "Whitney", "test", ";", "", "", "", "", "P", "<", "0.0001", "." ] } ]
PMC11740207	Identifying specific markers and mechanisms that lead to VSELSCs transforming into MCs could enable targeted therapies to be developed, which could precisely attack MCs during the early stages of their development, potentially being more effective than current treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identifying", "specific", "markers", "and", "mechanisms", "that", "lead", "to", "VSELSCs", "transforming", "into", "MCs", "could", "enable", "targeted", "therapies", "to", "be", "developed", ",", "which", "could", "precisely", "attack", "MCs", "during", "the", "early", "stages", "of", "their", "development", ",", "potentially", "being", "more", "effective", "than", "current", "treatments", "." ] } ]
PMC11082662	Invasion experiment evaluating the invasion of HEY ovarian cancer cells after ACER2 knockdown (100 µm); n=3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Invasion", "experiment", "evaluating", "the", "invasion", "of", "HEY", "ovarian", "cancer", "cells", "after", "ACER2", "knockdown", "(", "100", "µm", ")", ";", "n=3", ".", "(" ] } ]
PMC11767817	Our research group has modified curcumin to obtain more active compounds for a few years .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "group", "has", "modified", "curcumin", "to", "obtain", "more", "active", "compounds", "for", "a", "few", "years", "." ] } ]
PMC9429973	Documented infections were reported in 19 patients (44.2%) among which were 5 cases of clostridial colitis (11.6%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Documented", "infections", "were", "reported", "in", "19", "patients", "(", "44.2", "%", ")", "among", "which", "were", "5", "cases", "of", "clostridial", "colitis", "(", "11.6", "%", ")", "." ] } ]
PMC3681794	HIF-1 was stabilised in normoxia by exposing cells to cobalt chloride at either 50 µM (791T) or 25 µM (HOS and U2OS) for 24 hrs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1", "was", "stabilised", "in", "normoxia", "by", "exposing", "cells", "to", "cobalt", "chloride", "at", "either", "50", "µM", "(", "791", "T", ")", "or", "25", "µM", "(", "HOS", "and", "U2OS", ")", "for", "24", "hrs", "." ] } ]
PMC9429973	Aims: To explore the clinical and genetic associations of TERT variants in an unselected cohort of patients screened with a myeloid mutation next generation sequencing panel due to clinical suspicion of a myeloid neoplasia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "explore", "the", "clinical", "and", "genetic", "associations", "of", "TERT", "variants", "in", "an", "unselected", "cohort", "of", "patients", "screened", "with", "a", "myeloid", "mutation", "next", "generation", "sequencing", "panel", "due", "to", "clinical", "suspicion", "of", "a", "myeloid", "neoplasia", "." ] } ]
PMC9429973	In 30.7%, the classification was not possible due to missing data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "30.7", "%", ",", "the", "classification", "was", "not", "possible", "due", "to", "missing", "data", "." ] } ]
PMC11725127	Therefore, further investigations are required to fully understand the roles of USP2 in MM treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "further", "investigations", "are", "required", "to", "fully", "understand", "the", "roles", "of", "USP2", "in", "MM", "treatment", "." ] } ]
PMC8345486	Compounds 23, 16, and 18 showed slight but significant inhibition of the cell cycle at the S and G2 phases as well as DNA fragmentation (23 and 16, Figure 6A, left chart).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compounds", "23", ",", "16", ",", "and", "18", "showed", "slight", "but", "significant", "inhibition", "of", "the", "cell", "cycle", "at", "the", "S", "and", "G2", "phases", "as", "well", "as", "DNA", "fragmentation", "(", "23", "and", "16", ",", "Figure", "6A", ",", "left", "chart", ")", "." ] } ]
PMC11676169	Although colocalization of BCAT1 and KU70/KU80 is possible either in the cytoplasm or the nucleus, PLA assays suggest a weak interaction exists between BCAT1 and KU70 in the cytoplasm of leukemic cells under basal conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "colocalization", "of", "BCAT1", "and", "KU70/KU80", "is", "possible", "either", "in", "the", "cytoplasm", "or", "the", "nucleus", ",", "PLA", "assays", "suggest", "a", "weak", "interaction", "exists", "between", "BCAT1", "and", "KU70", "in", "the", "cytoplasm", "of", "leukemic", "cells", "under", "basal", "conditions", "." ] } ]
PMC11473843	Quantification of DHR (ROS marker, green) (left) and representative flow cytometry histogram (right) of A549 cells treated as in (C); n = 3. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "DHR", "(", "ROS", "marker", ",", "green", ")", "(", "left", ")", "and", "representative", "flow", "cytometry", "histogram", "(", "right", ")", "of", "A549", "cells", "treated", "as", "in", "(", "C", ")", ";", "n", "=", "3", ".", "(" ] } ]
PMC9429973	Aims: IMG-7289-CTP-102 is an ongoing, global, open-label Phase 2 study evaluating bomedemstat dosed QD in MF patients (NCT03136185).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "IMG-7289-CTP-102", "is", "an", "ongoing", ",", "global", ",", "open-label", "Phase", "2", "study", "evaluating", "bomedemstat", "dosed", "QD", "in", "MF", "patients", "(", "NCT03136185", ")", "." ] } ]
PMC6934009	The viability of A549 and A427 cells was reduced to 31% and 34%, respectively, on treatment with 50 μM of wogonin; however, there was no significant reduction in BEAS-2B cell viability on treatment with the same concentration of it.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "A549", "and", "A427", "cells", "was", "reduced", "to", "31", "%", "and", "34", "%", ",", "respectively", ",", "on", "treatment", "with", "50", "μM", "of", "wogonin", ";", "however", ",", "there", "was", "no", "significant", "reduction", "in", "BEAS-2B", "cell", "viability", "on", "treatment", "with", "the", "same", "concentration", "of", "it", "." ] } ]
PMC9429973	The lack of correlation between miRNA expression and sirtuins in the CR group may be associated with a small number of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lack", "of", "correlation", "between", "miRNA", "expression", "and", "sirtuins", "in", "the", "CR", "group", "may", "be", "associated", "with", "a", "small", "number", "of", "patients", "." ] } ]
PMC9587298	Elderberries phenols trap MGO decreasing the induced MGO cytotoxicity in HepG2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Elderberries", "phenols", "trap", "MGO", "decreasing", "the", "induced", "MGO", "cytotoxicity", "in", "HepG2", "cells", "." ] } ]
PMC8345486	The hybrid compounds obtained, consisting of an abiotic (metallacarborane) and organic moiety (adenine nucleoside), are expected to exhibit features of multifunctional compounds interacting with specific cellular targets of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hybrid", "compounds", "obtained", ",", "consisting", "of", "an", "abiotic", "(", "metallacarborane", ")", "and", "organic", "moiety", "(", "adenine", "nucleoside", ")", ",", "are", "expected", "to", "exhibit", "features", "of", "multifunctional", "compounds", "interacting", "with", "specific", "cellular", "targets", "of", "cancer", "cells", "." ] } ]
PMC7022782	Dimensional analysis by PCS of ICG-loaded NPs showed two different classes of NPs, ranging from 120 (ICG-NPs1) to 200 nm (ICG-NPs2), maybe influenced by the concentration of dye, increasing the dimensions and reducing the homogeneity of suspension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dimensional", "analysis", "by", "PCS", "of", "ICG-loaded", "NPs", "showed", "two", "different", "classes", "of", "NPs", ",", "ranging", "from", "120", "(", "ICG-NPs1", ")", "to", "200", "nm", "(", "ICG-NPs2", ")", ",", "maybe", "influenced", "by", "the", "concentration", "of", "dye", ",", "increasing", "the", "dimensions", "and", "reducing", "the", "homogeneity", "of", "suspension", "." ] } ]
PMC11204465	AFB1 (73), B2 (74) and G1 (87) modulate cytokine secretion and cell surface marker expression in J774A.1 mouse macrophages .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "AFB1", "(", "73", ")", ",", "B2", "(", "74", ")", "and", "G1", "(", "87", ")", "modulate", "cytokine", "secretion", "and", "cell", "surface", "marker", "expression", "in", "J774A.1", "mouse", "macrophages", "." ] } ]
PMC10788478	Previous studies have suggested that LGR6 is involved in the development of various human cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "suggested", "that", "LGR6", "is", "involved", "in", "the", "development", "of", "various", "human", "cancers", "." ] } ]
PMC9777812	In addition, our luciferase assay and rescue experiment also demonstrated the regulatory role of bta-miR-106b on CDKN1A expresion by targeting its 3′UTR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "our", "luciferase", "assay", "and", "rescue", "experiment", "also", "demonstrated", "the", "regulatory", "role", "of", "bta-miR-106b", "on", "CDKN1A", "expresion", "by", "targeting", "its", "3′UTR", "." ] } ]
PMC8864075	The primers were designed and synthesized by GenePharma (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "were", "designed", "and", "synthesized", "by", "GenePharma", "(", "Shanghai", ",", "China", ")", "." ] } ]
PMC11487720	A, B WWOXf HCT116 cells were exposed to UV and then cold shock at 4 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "B", "WWOXf", "HCT116", "cells", "were", "exposed", "to", "UV", "and", "then", "cold", "shock", "at", "4", "°", "C", "for", "10", "min", "." ] } ]
PMC9878278	TLR3 and TLR7 are not required to induce an antiviral response in SC following ZIKV infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TLR3", "and", "TLR7", "are", "not", "required", "to", "induce", "an", "antiviral", "response", "in", "SC", "following", "ZIKV", "infection", "." ] } ]
PMC11590870	The values of the antioxidant potential of MOP and MOPH determined by the FRAP assay are presented in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "values", "of", "the", "antioxidant", "potential", "of", "MOP", "and", "MOPH", "determined", "by", "the", "FRAP", "assay", "are", "presented", "in", "Table", "1", "." ] } ]
PMC11754432	50 µg of protein were run on 10% tris-glycine gels and transferred onto nitrocellulose membranes using a Trans-Blot Turbo transfer system (Bio-Rad, Hercules, California, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "50", "µg", "of", "protein", "were", "run", "on", "10", "%", "tris-glycine", "gels", "and", "transferred", "onto", "nitrocellulose", "membranes", "using", "a", "Trans-Blot", "Turbo", "transfer", "system", "(", "Bio-Rad", ",", "Hercules", ",", "California", ",", "USA", ")", "." ] } ]
PMC11665555	Larger group studies were analyzed with 1-way ANOVA at a 95% CI and Tukey multiple comparisons test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Larger", "group", "studies", "were", "analyzed", "with", "1-way", "ANOVA", "at", "a", "95", "%", "CI", "and", "Tukey", "multiple", "comparisons", "test", "." ] } ]
PMC11727062	This activation leads to an upregulation of the phosphorylation levels of downstream targets such as 4EBP1 and S6K1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "activation", "leads", "to", "an", "upregulation", "of", "the", "phosphorylation", "levels", "of", "downstream", "targets", "such", "as", "4EBP1", "and", "S6K1", "." ] } ]
PMC9444294	Nerve tissue within the monophasic tumor and blood vessels within the biphasic tumor served as internal negative controls (Fig. 4A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nerve", "tissue", "within", "the", "monophasic", "tumor", "and", "blood", "vessels", "within", "the", "biphasic", "tumor", "served", "as", "internal", "negative", "controls", "(", "Fig.", "4A", "and", "B", ")", "." ] } ]
PMC11743975	In all statistical analyses, P < 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "all", "statistical", "analyses", ",", "P", "<", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC11661040	Results from three experiments are summarized in a histogram format.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "from", "three", "experiments", "are", "summarized", "in", "a", "histogram", "format", "." ] } ]
PMC11686380	Sanger sequencing analysis of the GAP43 gene of the proband, her mother, and 2 sisters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sanger", "sequencing", "analysis", "of", "the", "GAP43", "gene", "of", "the", "proband", ",", "her", "mother", ",", "and", "2", "sisters", "." ] } ]
PMC9429973	The highly predictive response for SYK inhibition with concurrent NPM1m/FLT3-ITD mutations and synergy with gilteritinib observed in patient derived models is supportive of its clinical evaluation in combination with a FLT3 inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highly", "predictive", "response", "for", "SYK", "inhibition", "with", "concurrent", "NPM1m/FLT3-ITD", "mutations", "and", "synergy", "with", "gilteritinib", "observed", "in", "patient", "derived", "models", "is", "supportive", "of", "its", "clinical", "evaluation", "in", "combination", "with", "a", "FLT3", "inhibitor", "." ] } ]
PMC7724160	The day number, and passage number are indicated in the table for each sample as well as a general class of molecule for each metabolite.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "day", "number", ",", "and", "passage", "number", "are", "indicated", "in", "the", "table", "for", "each", "sample", "as", "well", "as", "a", "general", "class", "of", "molecule", "for", "each", "metabolite", "." ] } ]
PMC10218459	The TUNEL assay detected for the cell line RD-ES had a higher level of apoptotic signals with the combinations of cytostatics and CPP (both DOX and VIN) than the caspase 3/7 assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TUNEL", "assay", "detected", "for", "the", "cell", "line", "RD-ES", "had", "a", "higher", "level", "of", "apoptotic", "signals", "with", "the", "combinations", "of", "cytostatics", "and", "CPP", "(", "both", "DOX", "and", "VIN", ")", "than", "the", "caspase", "3/7", "assay", "." ] } ]
PMC9429973	Clinical, laboratory, cytogenetic, and molecular data were extracted from the institution’s electronic medical records system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", ",", "laboratory", ",", "cytogenetic", ",", "and", "molecular", "data", "were", "extracted", "from", "the", "institution", "’s", "electronic", "medical", "records", "system", "." ] } ]
PMC8382973	The viability of PBMCs (A), CEMss-CCR5 (B), MT-4 (C), and TZM-bl (D) cells treated with 2P23 formulated in gel or in PBS at graded concentrations was evaluated by CCK-8 assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "PBMCs", "(", "A", ")", ",", "CEMss-CCR5", "(", "B", ")", ",", "MT-4", "(", "C", ")", ",", "and", "TZM-bl", "(", "D", ")", "cells", "treated", "with", "2P23", "formulated", "in", "gel", "or", "in", "PBS", "at", "graded", "concentrations", "was", "evaluated", "by", "CCK-8", "assay", "." ] } ]
PMC11252033	Moreover, we demonstrated that treatment with ASA determines a significant decrease of Bcl-2 and Bcl-xl mRNA expression levels in A2780 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Moreover", ",", "we", "demonstrated", "that", "treatment", "with", "ASA", "determines", "a", "significant", "decrease", "of", "Bcl-2", "and", "Bcl-xl", "mRNA", "expression", "levels", "in", "A2780", "cells", "." ] } ]
PMC11023271	The PCR was run in duplicates and analyzed in Bio-Rad CFX Connect Real-time PCR System.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PCR", "was", "run", "in", "duplicates", "and", "analyzed", "in", "Bio-Rad", "CFX", "Connect", "Real-time", "PCR", "System", "." ] } ]
PMC11247842	The gene-based analysis indicated in total 64 genome-wide significant genes (see Additional file 1: Tables S7 and S8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene-based", "analysis", "indicated", "in", "total", "64", "genome-wide", "significant", "genes", "(", "see", "Additional", "file", "1", ":", "Tables", "S7", "and", "S8", ")", "." ] } ]
PMC11758416	1E5 cells are typically approximately 10% of a confluent flask which is the recommended subcultivation ratio for L cells.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1E5", "cells", "are", "typically", "approximately", "10", "%", "of", "a", "confluent", "flask", "which", "is", "the", "recommended", "subcultivation", "ratio", "for", "L", "cells", "." ] } ]
PMC6901583	The NF-κB circuit involves p65 phosphorylation and nuclear translocation, which influence gene activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NF-κB", "circuit", "involves", "p65", "phosphorylation", "and", "nuclear", "translocation", ",", "which", "influence", "gene", "activation", "." ] } ]
PMC10568263	Subsequently, we focused on the Mn 2p, O 1s, and Au 4f XPS spectra that were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "focused", "on", "the", "Mn", "2p", ",", "O", "1s", ",", "and", "Au", "4f", "XPS", "spectra", "that", "were", "analyzed", "." ] } ]
PMC9479186	In our study, we found that NDUFC1 is highly expressed in HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "study", ",", "we", "found", "that", "NDUFC1", "is", "highly", "expressed", "in", "HCC", "." ] } ]
PMC11590870	The FRAP solution was made by mixing acetate buffer (400 mM, pH 3.6), TPTZ (20 mM in concentrated HCl), and ferric chloride (60 mM) (10:1:1 v/v/v ratio).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FRAP", "solution", "was", "made", "by", "mixing", "acetate", "buffer", "(", "400", "mM", ",", "pH", "3.6", ")", ",", "TPTZ", "(", "20", "mM", "in", "concentrated", "HCl", ")", ",", "and", "ferric", "chloride", "(", "60", "mM", ")", "(", "10:1:1", "v/v/v", "ratio", ")", "." ] } ]
PMC11544122	Data were normalized and fit by nonlinear regression (one site-specific binding) using GraphPad Prism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "normalized", "and", "fit", "by", "nonlinear", "regression", "(", "one", "site-specific", "binding", ")", "using", "GraphPad", "Prism", "." ] } ]
PMC11622247	Secondly, microporation of probes targeting the TCR mRNA of CCRF CEM cells induce higher fluorescence levels in CCRF CEM cells than in Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Secondly", ",", "microporation", "of", "probes", "targeting", "the", "TCR", "mRNA", "of", "CCRF", "CEM", "cells", "induce", "higher", "fluorescence", "levels", "in", "CCRF", "CEM", "cells", "than", "in", "Jurkat", "cells", "." ] } ]
PMC11519567	The formation of SS18 protein condensates depended on the IDR sequence, and the SS18-SSX-enhanced condensates relied on H2AK119ub.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "formation", "of", "SS18", "protein", "condensates", "depended", "on", "the", "IDR", "sequence", ",", "and", "the", "SS18-SSX-enhanced", "condensates", "relied", "on", "H2AK119ub", "." ] } ]
PMC9841531	Thus again, the overall comparability of the literature data is limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", "again", ",", "the", "overall", "comparability", "of", "the", "literature", "data", "is", "limited", "." ] } ]
PMC11721295	As shown in Figure 6E (high magnification in Supplemental Figure 6E) and quantified in Figure 6F, p-STAT3 was activated in fibroblasts in the ON group, but reduced in the OFF groups, indicating dependence on extrinsic oncogenic KRAS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Figure", "6E", "(", "high", "magnification", "in", "Supplemental", "Figure", "6E", ")", "and", "quantified", "in", "Figure", "6F", ",", "p-STAT3", "was", "activated", "in", "fibroblasts", "in", "the", "ON", "group", ",", "but", "reduced", "in", "the", "OFF", "groups", ",", "indicating", "dependence", "on", "extrinsic", "oncogenic", "KRAS", "." ] } ]
PMC11188874	Generation of R110 fluorescence was directly proportional to cell number, incubation time, and substrate concentration, while at higher concentrations, DMSO reduced proteasome activity (Supplementary Fig. S2A–S2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generation", "of", "R110", "fluorescence", "was", "directly", "proportional", "to", "cell", "number", ",", "incubation", "time", ",", "and", "substrate", "concentration", ",", "while", "at", "higher", "concentrations", ",", "DMSO", "reduced", "proteasome", "activity", "(", "Supplementary", "Fig.", "S2A", "–", "S2D", ")", "." ] } ]
PMC11484188	Following transfection, cells were incubated for 24-48 h before subsequent experimentation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "transfection", ",", "cells", "were", "incubated", "for", "24", "-", "48", "h", "before", "subsequent", "experimentation", "." ] } ]
PMC11621493	Heterozygous animals were backcrossed four times on a C57BL/6NJ genetic background before switching to a homozygous breeding regime.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heterozygous", "animals", "were", "backcrossed", "four", "times", "on", "a", "C57BL/6NJ", "genetic", "background", "before", "switching", "to", "a", "homozygous", "breeding", "regime", "." ] } ]
PMC11676169	U2OS reporter cell lines were instead infected with lentiviral particles for pLenti-Myc-DDK-P2A-Puro empty vector, pLenti-BCAT1-Myc-DDK-P2A-Puro, or BCAT1 mutants (catalytically dead mutant where lysine 222 is mutated to alanine, i.e., BCAT1K222A, or redox motif inactive mutant BCAT1SXXS where cysteines 335 and 338 in the CXXC motif are mutated to serines).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U2OS", "reporter", "cell", "lines", "were", "instead", "infected", "with", "lentiviral", "particles", "for", "pLenti-Myc-DDK-P2A-Puro", "empty", "vector", ",", "pLenti-BCAT1-Myc-DDK-P2A-Puro", ",", "or", "BCAT1", "mutants", "(", "catalytically", "dead", "mutant", "where", "lysine", "222", "is", "mutated", "to", "alanine", ",", "i.e.", ",", "BCAT1K222A", ",", "or", "redox", "motif", "inactive", "mutant", "BCAT1SXXS", "where", "cysteines", "335", "and", "338", "in", "the", "CXXC", "motif", "are", "mutated", "to", "serines", ")", "." ] } ]
PMC11590870	After cleaning, leaves were dried at 40 °C for 72 h in an Excalibur 3526T food dehydrator (Sacramento, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "cleaning", ",", "leaves", "were", "dried", "at", "40", "°", "C", "for", "72", "h", "in", "an", "Excalibur", "3526", "T", "food", "dehydrator", "(", "Sacramento", ",", "CA", ",", "USA", ")", "." ] } ]
PMC2614415	Therefore, we tested if doses of VE-465 that were specific to Aurora-A (3 nM or less) could synergize with paclitaxel to induce apoptosis in the 1A9 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "tested", "if", "doses", "of", "VE-465", "that", "were", "specific", "to", "Aurora-A", "(", "3", "nM", "or", "less", ")", "could", "synergize", "with", "paclitaxel", "to", "induce", "apoptosis", "in", "the", "1A9", "cell", "line", "." ] } ]
PMC11476837	Recently, it was demonstrated that clinically doxorubicin-resistant leukemia cells overexpressed SOD2 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "it", "was", "demonstrated", "that", "clinically", "doxorubicin-resistant", "leukemia", "cells", "overexpressed", "SOD2", "." ] } ]
PMC11240448	Following a separation of luminal, basal, and normal cell states, we identified signaling nodes within core control networks, delineated causal connections, and determined the primary drivers underlying oncogenic transformation and transitions across distinct BC subtypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "a", "separation", "of", "luminal", ",", "basal", ",", "and", "normal", "cell", "states", ",", "we", "identified", "signaling", "nodes", "within", "core", "control", "networks", ",", "delineated", "causal", "connections", ",", "and", "determined", "the", "primary", "drivers", "underlying", "oncogenic", "transformation", "and", "transitions", "across", "distinct", "BC", "subtypes", "." ] } ]
PMC9429973	Image: Summary/Conclusion: In our experience, 35% of pts with mastocytosis eligible to receive the SARS-CoV2 vaccination, refused it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "In", "our", "experience", ",", "35", "%", "of", "pts", "with", "mastocytosis", "eligible", "to", "receive", "the", "SARS-CoV2", "vaccination", ",", "refused", "it", "." ] } ]

PMC11577421

Next, we compared NP uptake between untreated and enzyme-treated cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "compared", "NP", "uptake", "between", "untreated", "and", "enzyme-treated", "cells", "." ] } ]

PMC11640555

The amount of MTT reduced to formazan was quantified by measuring the optical density at 540 nm (OD540) with a microplate reader.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "amount", "of", "MTT", "reduced", "to", "formazan", "was", "quantified", "by", "measuring", "the", "optical", "density", "at", "540", "nm", "(", "OD540", ")", "with", "a", "microplate", "reader", "." ] } ]

PMC11756937

In general, for freezing, the cells were dissociated enzymatically, and the detached cell aggregates were centrifuged at 1100 rpm for 3 min at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "for", "freezing", ",", "the", "cells", "were", "dissociated", "enzymatically", ",", "and", "the", "detached", "cell", "aggregates", "were", "centrifuged", "at", "1100", "rpm", "for", "3", "min", "at", "room", "temperature", "." ] } ]

PMC6934009

Apoptosis, a complex process associated with the elimination of unwanted cells from the body, is controlled by several genes (12).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", ",", "a", "complex", "process", "associated", "with", "the", "elimination", "of", "unwanted", "cells", "from", "the", "body", ",", "is", "controlled", "by", "several", "genes", "(", "12", ")", "." ] } ]

PMC6133382

Underlaying data can be found in S2 Data.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Underlaying", "data", "can", "be", "found", "in", "S2", "Data", "." ] } ]

PMC11200978

The American Cancer Society reports about 1 in 5 cancer-related deaths to be caused by LC, resulting in more deaths than colon, breast, and prostate cancer combined .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "American", "Cancer", "Society", "reports", "about", "1", "in", "5", "cancer-related", "deaths", "to", "be", "caused", "by", "LC", ",", "resulting", "in", "more", "deaths", "than", "colon", ",", "breast", ",", "and", "prostate", "cancer", "combined", "." ] } ]

PMC11755467

Raw sequencing reads were aligned with the target reference sequence -pre-miR-hsa-132-, and experimental conditions were defined-modified, untreated, and denatured samples for comparative analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Raw", "sequencing", "reads", "were", "aligned", "with", "the", "target", "reference", "sequence", "-pre-miR-hsa-132-", ",", "and", "experimental", "conditions", "were", "defined-modified", ",", "untreated", ",", "and", "denatured", "samples", "for", "comparative", "analysis", "." ] } ]

PMC5574817

Chemiluminescence signal was analyzed using ChemiDoc XRS Imaging System (BioRad Laboratories, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemiluminescence", "signal", "was", "analyzed", "using", "ChemiDoc", "XRS", "Imaging", "System", "(", "BioRad", "Laboratories", ",", "USA", ")", "." ] } ]

PMC9739791

Without the reducing agent in the dark, the degradation of the Pt(IV) prodrug 27 was negligible, while in the presence of 5 equivalents of ascorbic acid the complex showed a 50% reduction within 24 h of incubation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Without", "the", "reducing", "agent", "in", "the", "dark", ",", "the", "degradation", "of", "the", "Pt(IV", ")", "prodrug", "27", "was", "negligible", ",", "while", "in", "the", "presence", "of", "5", "equivalents", "of", "ascorbic", "acid", "the", "complex", "showed", "a", "50", "%", "reduction", "within", "24", "h", "of", "incubation", "." ] } ]

PMC9429973

Vascular comorbidities were seen in 22 (50%) patients, the most frequent being hypertension (n=12, 27%), peripheral vascular disease (n=6, 14%), AF (n=6, 14%) and ischaemic heart disease (n=6, 14%).

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PMC10778532

Sunitinib treatment also conferred a more mesenchymal profile to VHL-C162F cells with significant downregulation of E-cadherin and upregulation of N-cadherin, Slug and AXL.

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PMC11592837

Similar to the DII of MTCO3, the DII of Alu in the control PBMCs rose over time; however, mean values were considerably lower, starting with 0.32 and reaching a maximum of 0.82 after 8 h (Figure 7B).

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PMC10093184

Bone is the only connective tissue producing ALPL in dogs and it can therefore be used to differentiate the canine osteosarcoma from other vimentin-positive tumors .

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PMC10197932

For Eryptosis assay, RBCs untreated and treated were resuspended in 200 μl of 1X Annexin Buffer plus 10 μl Annexin-V Alexa Fluor, then spun down at 800 x g 10 min washed with PBS + 0.1 % BSA and analyzed by Flow cytometry.

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PMC11577421

Cytotoxicity in HeLa cells exposed to PCX-loaded NPs. (

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PMC11754094

Identifying the repair pathways that produce large deletions following genome editing with Cas9 or nCas9 will not only provide key insight into the biology of this process but also enable the development of strategies to mitigate large-deletion events.

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PMC11721295

Fisher et al. showed that at 17–25 weeks, mice develop a measurable tumor burden, thus providing rationale for our analyses (8).

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PMC9516447

The homogenized lysates were incubated on ice for 30 minutes followed by centrifugation at 13,000 RPM for 15 minutes.

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PMC10849234

Following introduction of CRISPRi constructs and confirmation that Rab27a transcript levels were reduced (Fig 4A), we differentiated cells using DMSO and G-CSF, and then treated them with Cytochalasin B and fMLP to induce degranulation.

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PMC11633763

Based on these studies, it can be concluded that tumour cells prefer glycolysis to oxidative phosphorylation .

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PMC3765139

The authors declare that they have no competing interests.

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PMC10933092

The sh-TRMT61A oligonucleotide sequences were as follows.

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PMC10969097

MDR incorporates a variety of mechanisms that give cancer cells a survival advantage against cancer therapies .

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PMC11549062

Increased PTP1B levels disrupted the endo‐lysosomal interaction, resulting in the accumulation of PDGFR‐β and subsequent elevation in apoptosis, thereby fostering plaque vulnerability.

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PMC11585254

We note that in our experiments, binding between receptor and β-arrestin was measured by BRET, which is dependent upon the close proximity of the donor and acceptor molecules but can also be influenced by their orientation (Hamdan et al., 2006).

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PMC11737091

Three constructed shRNA sequences targeting DBF4 were used to silence DBF4 expression in ccRCC.

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PMC7215722

The DSS-induced ER-stress resulted in impaired intracellular trafficking and polarized sorting of sucrase-isomaltase (SI) and dipeptidyl peptidase-4 (DPPIV), which are normally sorted to the apical membrane via association with lipid rafts.

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PMC11653168

In addition, a significant reduction in tumor weight was detected in the 15 and 30 mg/kg Stattic, and 1 mg/kg DEX treatment groups relative to the control (Fig. 7D).

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PMC11763111

K Percentage of IL-10 expression in CCRF-CEM pre-incubated CAR-T with DMSO and 20 µ mol JSH-23 (n = 3).

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PMC10571053

One of the first reported inducers of ferroptosis, erastin, was described before the concept of ferroptosis was completely understood.

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PMC11347429

However, only some DEGs (169) were statistically significant in the direct contrast between ICU and non-ICU patients.

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PMC7039683

Best match, transcription factor in the indicated family with highest expression in GFP-positive cells, whether or not the expression is enriched in GFP-positive cells in comparison to GFP-negative cells. (

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PMC9429973

After a median follow-up of 13.5 months, ORR for cohort 1 was 73% (95% CI, 54-88; complete response, 7 patients [23%]; partial response, 15 patients [50%]).

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PMC11756514

Bacterial aggregation by SP-D. Bacteria incubated with or without SP-D (control) in either calcium or EDTA.

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PMC9429973

A bone marrow sample was obtained at diagnosis and when remission was achieved.

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PMC10440586

Therefore, for patients with gliomas with high expression of CD99, tumor adaptability should be fully considered clinically.

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PMC11352877

ANG1 acts as a paracrine agonist on TIE-2, leading to dimerization of the receptor and inducing its phosphorylation, which then activates target signaling molecules, increases the association of endothelial cells with pericytes and vascular smooth muscle cells, and stimulates maturation of the vascular network .

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PMC11319300

MYEOV is a young protein-coding gene, with an ORF exclusive to primates but the DNA sequence of the MYEOV-3′-putative enhancer region exhibited conservation not only across mammals but also in chicken.

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PMC10976516

Moreover, lung cancer patients are often diagnosed between the ages of 60 and 80, with the most frequent occurrence between 65 and 75.

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PMC11774747

Further investigations should focus on directly comparing these costimulatory domains while controlling for confounding variables.

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PMC11078693

Note: For this protocol, we used the commercial Biotium Mix-n-Stain Kit.

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PMC11224020

Data were analyzed by one-way Mann–Whitney test; ****P < 0.0001.

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PMC11740207

Identifying specific markers and mechanisms that lead to VSELSCs transforming into MCs could enable targeted therapies to be developed, which could precisely attack MCs during the early stages of their development, potentially being more effective than current treatments.

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PMC11082662

Invasion experiment evaluating the invasion of HEY ovarian cancer cells after ACER2 knockdown (100 µm); n=3. (

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PMC11767817

Our research group has modified curcumin to obtain more active compounds for a few years .

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PMC9429973

Documented infections were reported in 19 patients (44.2%) among which were 5 cases of clostridial colitis (11.6%).

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PMC3681794

HIF-1 was stabilised in normoxia by exposing cells to cobalt chloride at either 50 µM (791T) or 25 µM (HOS and U2OS) for 24 hrs.

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PMC9429973

Aims: To explore the clinical and genetic associations of TERT variants in an unselected cohort of patients screened with a myeloid mutation next generation sequencing panel due to clinical suspicion of a myeloid neoplasia.

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PMC9429973

In 30.7%, the classification was not possible due to missing data.

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PMC11725127

Therefore, further investigations are required to fully understand the roles of USP2 in MM treatment.

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PMC8345486

Compounds 23, 16, and 18 showed slight but significant inhibition of the cell cycle at the S and G2 phases as well as DNA fragmentation (23 and 16, Figure 6A, left chart).

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PMC11676169

Although colocalization of BCAT1 and KU70/KU80 is possible either in the cytoplasm or the nucleus, PLA assays suggest a weak interaction exists between BCAT1 and KU70 in the cytoplasm of leukemic cells under basal conditions.

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PMC11473843

Quantification of DHR (ROS marker, green) (left) and representative flow cytometry histogram (right) of A549 cells treated as in (C); n = 3. (

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PMC9429973

Aims: IMG-7289-CTP-102 is an ongoing, global, open-label Phase 2 study evaluating bomedemstat dosed QD in MF patients (NCT03136185).

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PMC6934009

The viability of A549 and A427 cells was reduced to 31% and 34%, respectively, on treatment with 50 μM of wogonin; however, there was no significant reduction in BEAS-2B cell viability on treatment with the same concentration of it.

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PMC9429973

The lack of correlation between miRNA expression and sirtuins in the CR group may be associated with a small number of patients.

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PMC9587298

Elderberries phenols trap MGO decreasing the induced MGO cytotoxicity in HepG2 cells.

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PMC8345486

The hybrid compounds obtained, consisting of an abiotic (metallacarborane) and organic moiety (adenine nucleoside), are expected to exhibit features of multifunctional compounds interacting with specific cellular targets of cancer cells.

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PMC7022782

Dimensional analysis by PCS of ICG-loaded NPs showed two different classes of NPs, ranging from 120 (ICG-NPs1) to 200 nm (ICG-NPs2), maybe influenced by the concentration of dye, increasing the dimensions and reducing the homogeneity of suspension.

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PMC11204465

AFB1 (73), B2 (74) and G1 (87) modulate cytokine secretion and cell surface marker expression in J774A.1 mouse macrophages .

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PMC10788478

Previous studies have suggested that LGR6 is involved in the development of various human cancers.

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PMC9777812

In addition, our luciferase assay and rescue experiment also demonstrated the regulatory role of bta-miR-106b on CDKN1A expresion by targeting its 3′UTR.

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PMC8864075

The primers were designed and synthesized by GenePharma (Shanghai, China).

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PMC11487720

A, B WWOXf HCT116 cells were exposed to UV and then cold shock at 4 °C for 10 min.

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PMC9878278

TLR3 and TLR7 are not required to induce an antiviral response in SC following ZIKV infection.

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PMC11590870

The values of the antioxidant potential of MOP and MOPH determined by the FRAP assay are presented in Table 1.

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PMC11754432

50 µg of protein were run on 10% tris-glycine gels and transferred onto nitrocellulose membranes using a Trans-Blot Turbo transfer system (Bio-Rad, Hercules, California, USA).

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PMC11665555

Larger group studies were analyzed with 1-way ANOVA at a 95% CI and Tukey multiple comparisons test.

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PMC11727062

This activation leads to an upregulation of the phosphorylation levels of downstream targets such as 4EBP1 and S6K1.

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PMC9444294

Nerve tissue within the monophasic tumor and blood vessels within the biphasic tumor served as internal negative controls (Fig. 4A and B).

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PMC11743975

In all statistical analyses, P < 0.05 was considered statistically significant.

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PMC11661040

Results from three experiments are summarized in a histogram format.

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PMC11686380

Sanger sequencing analysis of the GAP43 gene of the proband, her mother, and 2 sisters.

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PMC9429973

The highly predictive response for SYK inhibition with concurrent NPM1m/FLT3-ITD mutations and synergy with gilteritinib observed in patient derived models is supportive of its clinical evaluation in combination with a FLT3 inhibitor.

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PMC7724160

The day number, and passage number are indicated in the table for each sample as well as a general class of molecule for each metabolite.

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PMC10218459

The TUNEL assay detected for the cell line RD-ES had a higher level of apoptotic signals with the combinations of cytostatics and CPP (both DOX and VIN) than the caspase 3/7 assay.

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PMC9429973

Clinical, laboratory, cytogenetic, and molecular data were extracted from the institution’s electronic medical records system.

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PMC8382973

The viability of PBMCs (A), CEMss-CCR5 (B), MT-4 (C), and TZM-bl (D) cells treated with 2P23 formulated in gel or in PBS at graded concentrations was evaluated by CCK-8 assay.

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PMC11252033

Moreover, we demonstrated that treatment with ASA determines a significant decrease of Bcl-2 and Bcl-xl mRNA expression levels in A2780 cells.

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PMC11023271

The PCR was run in duplicates and analyzed in Bio-Rad CFX Connect Real-time PCR System.

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PMC11247842

The gene-based analysis indicated in total 64 genome-wide significant genes (see Additional file 1: Tables S7 and S8).

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PMC11758416

1E5 cells are typically approximately 10% of a confluent flask which is the recommended subcultivation ratio for L cells.

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PMC6901583

The NF-κB circuit involves p65 phosphorylation and nuclear translocation, which influence gene activation.

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PMC10568263

Subsequently, we focused on the Mn 2p, O 1s, and Au 4f XPS spectra that were analyzed.

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PMC9479186

In our study, we found that NDUFC1 is highly expressed in HCC.

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PMC11590870

The FRAP solution was made by mixing acetate buffer (400 mM, pH 3.6), TPTZ (20 mM in concentrated HCl), and ferric chloride (60 mM) (10:1:1 v/v/v ratio).

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PMC11544122

Data were normalized and fit by nonlinear regression (one site-specific binding) using GraphPad Prism.

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PMC11622247

Secondly, microporation of probes targeting the TCR mRNA of CCRF CEM cells induce higher fluorescence levels in CCRF CEM cells than in Jurkat cells.

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PMC11519567

The formation of SS18 protein condensates depended on the IDR sequence, and the SS18-SSX-enhanced condensates relied on H2AK119ub.

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PMC9841531

Thus again, the overall comparability of the literature data is limited.

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PMC11721295

As shown in Figure 6E (high magnification in Supplemental Figure 6E) and quantified in Figure 6F, p-STAT3 was activated in fibroblasts in the ON group, but reduced in the OFF groups, indicating dependence on extrinsic oncogenic KRAS.

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PMC11188874

Generation of R110 fluorescence was directly proportional to cell number, incubation time, and substrate concentration, while at higher concentrations, DMSO reduced proteasome activity (Supplementary Fig. S2A–S2D).

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PMC11484188

Following transfection, cells were incubated for 24-48 h before subsequent experimentation.

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PMC11621493

Heterozygous animals were backcrossed four times on a C57BL/6NJ genetic background before switching to a homozygous breeding regime.

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PMC11676169

U2OS reporter cell lines were instead infected with lentiviral particles for pLenti-Myc-DDK-P2A-Puro empty vector, pLenti-BCAT1-Myc-DDK-P2A-Puro, or BCAT1 mutants (catalytically dead mutant where lysine 222 is mutated to alanine, i.e., BCAT1K222A, or redox motif inactive mutant BCAT1SXXS where cysteines 335 and 338 in the CXXC motif are mutated to serines).

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PMC11590870

After cleaning, leaves were dried at 40 °C for 72 h in an Excalibur 3526T food dehydrator (Sacramento, CA, USA).

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PMC2614415

Therefore, we tested if doses of VE-465 that were specific to Aurora-A (3 nM or less) could synergize with paclitaxel to induce apoptosis in the 1A9 cell line.

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PMC11476837

Recently, it was demonstrated that clinically doxorubicin-resistant leukemia cells overexpressed SOD2 .

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PMC11240448

Following a separation of luminal, basal, and normal cell states, we identified signaling nodes within core control networks, delineated causal connections, and determined the primary drivers underlying oncogenic transformation and transitions across distinct BC subtypes.

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PMC9429973

Image: Summary/Conclusion: In our experience, 35% of pts with mastocytosis eligible to receive the SARS-CoV2 vaccination, refused it.

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