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OTAR3088
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PMC9917080
The fluorescence of the probes was registered with a fluorescent system based on an inverted fluorescent microscope Axio Observer Z1 equipped with a high-speed monochrome CCD-camera Hamamatsu ORCA-Flash 2.8.
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PMC11540664
In total, 72 patients were included in this study, with a median follow-up of 1.5 years.
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PMC11806106
cDNAs for the rat µ opioid receptor (MOR-wt), MORsYFP2, Gβ1-wt, GRK2-wt, PTX-insensitive Gαo, mTurq-Gγ2 and BRET-based activity sensor Go1 -case have been described before.
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PMC8633974
The recovered Sanger traces were subjected to sequence alignment to confirm the correct viral excision fragment (Figure 5h).Figure 5Synthesis, Characterization, and Antiretroviral Activity of CRISPR-Cas9 LNPs in Primary Human Monocyte-Derived Macrophages (MDM). (
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PMC9429973
Aims: Prompted by our recent study describing a considerable HLA diversity between a representative Cretan cohort and the donors of DKMS, we set out to unravel the effect of potential intra-population diversity on HLA distribution.
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PMC11740573
Further experiments also are needed for molecular, biochemical, and in vivo evaluation of interactions between calcitriol and antibiotics and calcitriol with bacterial cells.
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PMC10421378
Lepock reported that the onset temperature of protein denaturation is correlated with growth inhibition and the onset of cell lethality.
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PMC11610461
and “***” indicate p < 0.05, p < 0.01 and p < 0.001, respectively.
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PMC11629143
In this way, assembly of the pre‐initiation complex and recruitment of RNA polymerases are facilitated upon histone acetylation, leading to increased transcriptional output .
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PMC11643361
This highlights the promising potential of silver(I) scorpionate complexes as anticancer agents, especially in drug-resistant cancer cells.
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PMC11787381
A formulation of bambuterol (liposome in thermosensitive gel at 1 mg/mL) was administered by single IN route into male CBA mice (300 μg/kg), or a 0.1 mg/mL saline solution of bambuterol was injected by single intravenous (IV) route (300 μg/kg).
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PMC11578343
With a throughput of 600 cells per hour and demonstrated ease‐of‐use, mz‐visco‐NPS reveals a remarkable level of single‐cell heterogeneity that would otherwise be masked by ensemble averaging.
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PMC11387401
A gray dashed line shows the 0.05 significance cutoff. (
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PMC11098378
For instance, 21 effectors only rescued one of the four arboviruses screened (Fig 2F).
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PMC11628309
Research indicates that simply overexpressing either the wild-type (WT) α-synuclein or its A30P mutant significantly reduces cell viability of the BE (2)-M17 cells.
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PMC9429973
Molecular characterization was performed by automatic Sanger sequencing.
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PMC11585994
Experimental design utilizing the T-ALL patient-derived xenograft mouse model.
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PMC7823217
Less toxic photoinitiator or visible light photocrosslinking approaches may solve these issues.
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PMC9429973
Findings from this study require validation with further large scale RCTs with longer follow up time.
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PMC9220170
The resulting cDNA was used as a template for real-time PCR using the qPCRmix–HS SYBR mixture (Evrogen, Moscow, Russia).
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PMC9429973
In patients underwent HCT, compared to the values before HCT, the number of identified species has decreased to about half at day 28 after HCT and decreased further at day 56 after HCT.
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PMC11367146
MMP9showed a binding affinity of −10.1 kcal/mol with daucosterol, forming hydrogen bonds at GLY 186, TYR 248 and -9.3 kcal/mol with gigantol with hydrogen bonds at ALA 189, ALA 242, LEU 243, TYR 248 residues.
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PMC11792090
The expressions of the CD70 CAR and CD47 were validated using flow cytometry analysis ( Figure 4D ).
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PMC11321678
The cell counts of GFAP and IBA1 in different groups demonstrated significantly lower GFAP cells and increased IBA1 cells in both tumor regions for shHTR2C and shGABRG2 (Figure 6H–J).
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PMC11536589
Due to the release of damage-associated molecular patterns, ferroptosis generally is pro-inflammatory.
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PMC11786767
Light gray and blue backgrounds indicate the regions of two adjacent chromosomes for measurement.
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PMC3164356
Approximately 37.79% of the CHO-K1 genome is made up of transposable elements, as estimated from a combination of de novo repeat identification using RepeatModeller and analysis against the Repbase library.
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PMC10667689
For the HL-60 cell line, 24 h after treatment, the mRNA level of ATGL was significantly increased in comparison to the control group but showed a significant decrease compared to the PMA group.
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PMC11085211
Therefore, GIST-882 cells were treated with pure β-arbutin at 200 µg/mL. However, no significant effect was detected on GIST-882 cell viability and apoptosis up to 72 h after treatment, indicating that β-arbutin was not the compound responsible for FR2-A activity (Supplementary Figure S5b).
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PMC11342785
Fine-scale truncations of the N-terminal IDR and C-terminal IDRs in this context showed that droplet size scaled with the length of the IDR extension (Fig. 1, G and H) and correlated with performance in our MT-bundling and single-MT binding assays (Figs. 1, F–H and S2B).
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PMC11509224
Diacarperoxides H–J showed antimalarial activity against Plasmodium falciparum (W2 clones) in vitro, with IC50 values of 12.9, 4.8, and 1.8 µM, respectively, while diacarperoxides H–I exhibited activity against P. falciparum (D6 clones), with IC50 values of 7.9 and 1.6 µM, respectively.
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PMC11470381
Perform Fit Ellipse on the cell ROI to extract the shape parameters, then bisect each cell ROI into equal parts along the minor axis using the following calculations: From the Angle value given by ImageJ, calculate the angle subtended by the minor axis of the fitted ellipse on the x-axis of the image (Figure 4A).
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PMC10079526
J MCODE was used to extract the most interconnected clusters from the STRING network analysis in I. Cluster 1 represents proteins involved in methylation.
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PMC11350568
To demonstrate whether our TMPDS enters cells through different pathways, we conducted transport inhibition experiments by adding various inhibitors, including phagocytosis, macrophagy, clathrin-mediated, and vesicle-dependent pathways (Figures 3e and S3).
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PMC11803210
Repository name: Gene Expression Omnibus, figshareData identification number: GSE277758, 28152686Direct URL to data:1 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2777582 10.6084/m9.figshare.28152686.v3Related research articleN/A •The pathway analyses and differentially expressed genes induced by Nar treatment...
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PMC11420784
GAPDH was used as a loading control.
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PMC10919056
Subsequently, total RNA was transcribed into complementary DNA (cDNA) using the HiScript II Q RT SuperMix Kit (Vazyme).
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PMC11679033
The main fungi genera found on cannabis plants belong to the Aspergillus genera, known for producing a wide range of mycotoxins such as aflatoxins, ochratoxin A (OTA), sterigmatocystin, patulin, citrinin (CIT) and others .
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PMC11055323
f A Model for condensate remodeling as a driver for synovial sarcoma.
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PMC8839885
Previously, we demonstrated that uptake of our novel platinum compound RJY13 is independent of CTR1 .
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PMC9429973
PoS and Elmin were able to distinguish between SS and other genotypes, regardless of HU treatment.
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PMC9429973
In the first cohort, up to 10 volunteers will receive FTX-6058 6 mg once daily orally for 4 weeks.
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PMC11583010
HA22 (enfortumab) was generated from the published available sequences.
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PMC5417661
By the development of NOV202 we aimed at overcoming one or more of these issues.
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PMC11188874
RPMI-8226 cells (30,000/well) were incubated in 30 µL with each agent at a final concentration of 3 µmol/L in 384-well plates.
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PMC11394730
Thirdly, natural products have the ability to inhibit the glycolysis of tumor cells by acting on the PI3K/Akt/mTOR or AMPK pathways .
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PMC10706275
The electrophoretic patterns of PCR stock (Figure 6B,C) revealed product sizes of approximately 4100-bp for the 5′-homologous arms and 5000-bp for the 3′-homologous arms.
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PMC10957991
TRPV4 ion channel is one of the mechanosensors, prominently expressed in the basal stem cells and impacting cellular processes via physical changes in the microenvironment.
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PMC11204465
One new compound, 11-hydroxy-O-methyldihydrosterigmatocystin (71), was isolated from Aspergillus versicolor .
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PMC9429973
These alterations seemed to be induced by proinflammatory cytokines such as interferon-gamma (INF-γ) derived from allo-T cells, as the increased number of T cells and high levels of INF-γ in BM were observed in allo-SCT mice.
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PMC11486946
The 53 hit compounds beyond the upper threshold are indicated by the colored and white circles.
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PMC10253553
To this end, we transiently transfected 786-0 ccRCC cells with short interfering RNA (siRNA) corresponding to RICTOR or non-targeting (NT) siRNA.
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PMC11366496
RNF122 refers to Ring Finger Protein 122, a gene that encodes a protein involved in the cell cycle regulation.
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PMC9429973
The occurrence of chronic graft versus host disease was the only identified adverse factor affecting each subscale of QoL. Physical and mental component summaries in adults as well as physical, mental, social, and role well-being in children were all similar between HID and ISD SCT at 5-year points.
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PMC11789597
GAPDH was included as a loading control.
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PMC10669966
We investigated RNA sequence data from a large clinical LPS sample series and an in silico transcriptome database consisting of 201 tissue types.
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PMC9268183
Breast cancer was amongst the most diagnosed cancer types in 2020, followed by lung, colon and rectum, prostate, skin (non-melanoma) and stomach cancer.
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PMC11352311
Seven core protein targets were selected for docking with esculin.
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PMC11453295
Overall, analysis of the RNAseq data suggests that the loss of E-cadherin in HMECS impacts proliferation and EMT, which will be explored in future studies.
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PMC11155445
Compounds (142c and 142h) showed inhibition with IC50 values of 0.725 ± 0.068, and 1.24 ± 0.96 μM, respectively.
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PMC10092581
Metal‐complexes with the [Se(IPr)] and [Se(SIPr)] ligands were the weakest among the series whereas those characterized by [Se(IPr)] ligands were the most cytotoxic derivatives.
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PMC9429973
Molecular analysis also showed differences, as the FLT3-ITD mutation, was observed in only one case (4.2%) with dn-AML-MDS while in 30% with s-AML-MDS, respectively (p=0.02).
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PMC11687167
The molecular profile of evolocumab consists of two disulfide-bonded human heavy chains and each of them is covalently linked to a kappa light chain .
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PMC4485786
The A204 cell line was characterized with antibodies against ULBP-1(Z-9), ULBP-2(2F9), ULBP-3(F16), ULBP-4(6E6) (Santa Cruz Biotechnology, USA); MICA/B(6D4)APC CD112(R2.525)PE, CD155(SKII.4)PE (Biolegend, Germany); HLA-ABC(W6/32)PE (DAKO Cytomation, Germany); secondary antibody RAM-PE(X56) (BD PharMingen, Germany); and...
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PMC11279598
A critical step in the apoptosis pathway is the activation of caspases that lead, in turn, to the cleavage of several cell substrates required for cell viability .
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PMC10809689
Full-length blots/gels of b-actin, mTOR and GLS in the HL-60 cell line are presented in Supplementary Fig. 1 (a.), Fig. 2 (a.) and Fig. 3 (a.), respectively.
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PMC8358006
Further information on research design is available in the Nature Research Reporting Summary linked to this article.
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PMC9429973
Compassion of groups were carried out using χ2 test.
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PMC9429973
Figure 1 E) Image: Summary/Conclusion: The aberrant expression of hsa_circ_0001599 in PBMCs may be a new diagnostic marker and therapeutic target for intestinal aGVHD.
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PMC11742290
metastatic tumor (n = 14), normal ovarian tissue (n = 8) Reduced proliferation was observed in cells transfected with LGR5OvarianOvarian cancer cell lines: OVCAR-3 and SNU-8Adhesion LGR5 depletion led to a downregulation of L1 cell adhesion molecule expressionBrainBrain CSC lines NCH421k and NCH441 cells Overexpression...
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PMC11269933
The background colors of sequence name represent different phyla.
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PMC6889484
The apparent cure of the “Berlin patient” and recent long-term HIV-1 remission of another patient by transplantation of hematopoietic stem cells that did not express coreceptor chemokine receptor 5, or CCR5, have raised hopes of a cure.
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PMC11144200
Because of the tumor tissue’s increased permeability and retention (EPG) impact, it can cause specific aggregation of loaded macromolecular drugs or nanoparticles at the tumor site, thus forming a certain passive targeting effect .
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PMC10748106
Vincristine, irinotecan, etoposide, and paclitaxel are plant-derived drugs used to treat cervical cancer clinically, alone, and as neoadjuvant chemotherapy with other chemotherapeutics such as cisplatin ; natural products are essential molecules since they comprise 50% of anti-tumor drugs .
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PMC11788920
This effective suppression is also reflected in cell viability assays in which we observe significantly higher inhibition when these two sites are simultaneously targeted with dCas9.
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PMC9429973
Image: Summary/Conclusion: The majority of pts with ND AML in the Connect Myeloid Disease Registry would have been ineligible for a non-IC RCT due to being too fit or unfit.
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PMC8526701
Results were expressed as means ± SD of three independent experiments. *
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PMC9429973
Secondary endpoints included PFS with dropouts treated as censoring (Kaplan-Meier [KM] method), overall survival (OS), overall response rate (ORR), percentage of patients with very good partial response (VGPR) or better, healthcare resource utilization, time to next treatment (TTNT), and safety.
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PMC8916024
In the gut of Radix auricularia snails, Mycoplasmataceae and Chloroflexaceae were the dominant bacteria (Hu et al., 2018), and Aeromonadaceae, Sediminibacterium, and Cloacibacterium were the most abundant genera in the gut of Pomacea canaliculata snails (Li et al., 2019).
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PMC11650848
It was therefore unclear whether methylation would vary stochastically on each haplotype, and we could not fully rule out other effects such as parental imprinting.
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PMC9398137
We and others have previously shown that co-targeting MCL1 with non-specific inhibitors (e.g., homoharringtonine or inhibitors of cyclin-dependent kinases) and BCL2 with venetoclax might be synergistic in subsets of DLBCL (19, 46).
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PMC11055323
The gray areas in the figure indicate the dip depth range of the unbleached half corresponding to the LLPS.
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PMC11718031
In part 2, we selected four basal media (the top three basal media from part 1 and CD-CHO™ as a control medium) and seven different feeds to make different combinations and evaluated their impact on bioproduction performance.
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PMC9429973
L. Proietti, E. Heyes, T. Eder, T. Brandstoetter, G. Manhart, V. Sexl, F. Grebien Institute for Medical Biochemestry; Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria Background: C/EBPα is a key myeloid transcription factor that regulates the switch between proliferati...
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PMC9429973
The glucose consumption and lactate production rates were detected by glucose assay kit and lactate assay kit.
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PMC7612475
Moreover, the suppression of new origin firing following exposure to HU was also similar between the WT and mutant cell line, indicative that the ATR-dependent intra-S phase checkpoint is unaffected (Fig. 3C).
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PMC11612626
The peak area of ∼450 eluted peptides was ≥2-fold greater after treatment with compound A. The relative level of SIINFEKL peptide eluted from MHC-class I (M1/42) molecules was ∼2-fold higher after compound A treatment compared with vehicle treated controls, whereas SIINFEKL peptide copy number/cell was increased three-...
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PMC9019892
However, combination toxicity was an important factor that limited the ability of this study to meet its primary end point .
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PMC11127909
D WB examination of the protein levels of EFHD1 in OS cell lines, N = 3.
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PMC11635087
The maize starch was removed by centrifugation, DNAaseI (Merck, Dn25-1g) was added to the supernatant and placed on ice for 1 h. In a 50 mL tube, Percoll mixed with 300 mM sucrose buffer (20 mM Tris-HCl, 5 mM EGTA, 5 mM MgCl2・6H2O, 5 mM KCl) created layers of 80% , 60%, 40% and 0%, the homogenized solution was placed o...
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PMC11806613
LRP8 promotes translation of selenoproteins (SELs) like GPX4 by promoting selenium uptake [9–12].
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PMC8557138
In normal physiology, neoangiogenesis is involved in the development of the embryo and wound healing.
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PMC9621239
Patients with double mutations K130M/V131I, triple mutations I127T/K130M/V131I or K130M/V131I/F132Y were reported to have an increased prevalence of HBV-related liver diseases progression to HCC.
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PMC11694625
The synthetic procedures of 3a–3d were similar and displayed in Scheme 1, only the synthesis of 3a was described in detail.
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PMC11543853
The resolutions of the reconstructions were estimated according to the FSC 0.143 criterion.
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PMC9429973
NAC treatment prevented ROS production, cell death, apoptosis and DNA damage accumulation induced by CDK7i, indicating a causative link between increased ROS levels upon CDK7i and tumor cell death.
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PMC11087055
Aphidicolin potentially induces apoptosis (Glynn et al., 1992), which might indirectly lead to the cell flow changes through tissue tension alterations.
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PMC11655498
In Burkitt lymphoma cell lines, TGF-β1 is shown to activate EBV lytic replication (di Renzo et al., 1994).
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PMC11224020
EOP values close to 1 indicate a highly folded (and thus less tensed) envelope, whereas EOP values close to 0 indicate a smooth surface with fewer folds (and thus a more tensed envelope).
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PMC11774747
Additionally, it can expedite the process in SOT or in case of immunodeficiency, by using a readily available donor or ready-to-use HLA-typed antiviral VST from a bank ( Figure 1 ).
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