OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC10854447	Calc. (%)	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Calc", ".", "(", "%", ")" ] } ]
PMC11746948	Paraffin sections were cut as described above and stained with hematoxylin and eosin using an automated H&E staining workstation (HistoCore SPECTRA, Leica).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11591030	However, treatment with LPS in combination with AOP, PDTC, or both (LPS + AOP, LPS + PDTC, LPS + PDTC + AOP) mitigated the overexpression of these genes challenged by LPS and increased the expression of the IkBα gene (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	At later stages of apoptosis, phosphatidylserine will be present, along with a high degree of cell membrane comprise, enabling the binding of both Annexin V and PI (double positive, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11172027	The use of 250 and 500 µg/mL after 72 h of incubation also showed no difference to the initial control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "25...
PMC11506827	The cells were then stained with 4′,6-diamidino-2-phenylindole, visualized using an ECLIPSE Ts2R inverted microscope (Nikon, Melville, NY, USA), and imaged using NIS-Elements BR software (Ver 4.00, Nikon).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	In addition, PTPRZ1 was overexpressed in low-grade glioma (LGG) (Supplementary Fig. 1a), and its expression correlated positively with ABSOLUTE tumor purity (Supplementary Fig. 1b, c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The latter activates TBK1 and IKK kinases that, in turn, activate IRF3 and NF-κB, which induce expression of interferons and other cytokines involved in anti-tumor immune responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	L. Araujo de Albuquerque Simoes, I. Weinhäuser, D. A Pereira-Martins, C. A. Ortiz Rojas, T. Mantello Bianco, R. D. C. Cavaglieri, E. Magalhães Rego Center of Translational Research in Oncology, ICESP - Faculty of Medicine, USP, Sao Paulo; Center for Cell Based Therapy, Fundação Hemocentro de Ribeirão Preto, Ribeirão Pr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10798140	C NMR (126 MHz, DMSO-d6) δ: 153.66, 152.81, 138.46, 137.70, 133.10, 130.37, 130.12, 126.70, 124.87, 123.61, 119.15, 114.84, 86.12, 65.94, 47.18.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627398	Compared to low-LIAS or low-LIPT1 group, 149 and 142 pathways, respectively, including fatty acid metabolism, lipoic acid metabolism and carbon metabolism pathways, were enriched in high-LIAS or high-LIPT1 group (Fig 4C and 4D and S7 Table). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712	For females who are not postmenopausal (<24 months of amenorrhea) or who are not surgically sterile (absence of ovaries and/or uterus), a highly effective method of contraception together with a barrier method must be used from the start of the preconditioning stage and for at least 12 months after the last dose of AUT...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	In the transwell assay, the oe group showed enhanced migration and invasion compared to the nc group, but co-transfection with oe and miR-211-5p led to suppressive effects on these properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	F Changes of iron did not influence apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Changes", "of", "iron", "did", "not", "influence", "apoptosis", "." ] } ]
PMC9429973	All data was extracted from electronical medical records.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "was", "extracted", "from", "electronical", "medical", "records", "." ] } ]
PMC5963610	Anti-EGFR antibody (Nimotuzumab) was registered in Cuba, for the treatment of several epithelial tumors mostly in combination with chemo or/and radiotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11506670	This suggests that the NRAS missense mutations may not have substantially altered the structure of the wild-type protein, which is expected of single nucleotide variations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3734024	For B cell stimulation cultures, CD19 cells were added to a confluent layer of irradiated (30 Gy) CD40L-expressing fibroblasts in 24- or 96-well flat-bottomed culture plates in the presence or absence of 50 ng/mL recombinant mouse IL-5 and/or IL-4 (Peprotech Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380454	We demonstrated that the tellurium(IV)-thiol chemical bond formed between AS101 and the α4-chain led to a conformational change in the VLA-4 integrin, preventing its interaction with its specific ligand and consequent signal transduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4360730	Figure 1.Experimental metadata annotated with appropriate ontology terms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1.Experimental", "metadata", "annotated", "with", "appropriate", "ontology", "terms", "." ] } ]
PMC11257988	KRAS status as a predictive biomarker for lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KRAS", "status", "as", "a", "predictive", "biomarker", "for", "lung", "cancer", "." ] } ]
PMC9429973	Thrombin generation and D-dimer showed no changes after mRNA vaccination compared with baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thrombin", "generation", "and", "D-dimer", "showed", "no", "changes", "afte...
PMC11740508	In contrast, HRR intact cells have the ability to accurately repair damage during each S-Phase to maintain low damage levels and thus preserve viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	All patients provided informed consent in accordance with an IRB-approved protocol and the Declaration of Helsinki.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "provided", "informed", "consent", "...
PMC5963610	Figure 1E indicates the experimental scheme.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1E", "indicates", "the", "experimental", "scheme", "." ] } ]
PMC11714165	n = 3.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "." ] } ]
PMC10728535	Moreover, the human protein atlas (https://www.proteinatlas.org) and GeneCards (https://www.genecards.org) were used for further investigation of DEGs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC6222635	An adequate amount of the PPF and DPF was weighed and dissolved in distilled water to a fixed concentration of 1 mg/mL to obtain sample solutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8409415	The black bar indicates the median score of intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "black", "bar", "indicates", "the", "median", "score", "of", "intensity", "." ] } ]
PMC11119602	The cell colonies collected from cisplatin-treated flasks were named HepG2/cr cells and the morphology of both cell lines was monitored using inverted phase contrast microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC3203927	Three-dimensionality biomarkers would provide the intellectual basis for material discovery platform development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three-dimensionality", "biomarkers", "would", "provide", "the", "intellectual", "basis", ...
PMC11461833	Through subsequent experimental verification, we found that compared with that in empty vector-transfected of HEK293 cells, the expression of STXBP5 was upregulated in our progerin-expressing cell model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Conventional 2D monolayer culture, monolayer co-culture, cells grown over floating membranes, and cell monolayer sandwiched between membranes, are the commonly used 2D cancer models in research and drug screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	Female NOD/SCID/γc null (NSG) and male NMRI nude mice were obtained from Charles River Laboratories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Female", "NOD/SCID/γc", "null", "(", "NS...
PMC5925824	When tumors reached volumes of ~ 300 mm (~ 4–5 weeks), 2.5 × 10 expanded human T cells were administered intravenously (IV) and mice were treated with weekly IP injections of human IgG1 or LY3300054 at 10 mg/kg for a total of four doses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	These actions offer new insights and potential therapeutic strategies for melanoma treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "actions", "offer", "new", "insights", "and", "potential", "therapeutic", ...
PMC5810978	Another condition tested only for HuNoVs that resulted in a substantial increased HuNoV RNA level was the long-term (1 and 2 months) culturing of Caco-2 cells using the PEDV medium .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given that α7nAChR transduces the cholinergic regulation of normal HSCs by BMSCs, we utilised LepR-Cre;Chrna7f/f mice to conditionally delete this signalling pathway in leukaemic mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11394112	Although traditional subcutaneous xenograft DLBCL mouse models allow for adequate drug discovery studies, the major limitation is the localized tumor growth in an often clinically non-relevant tissue that constrains the translation of how effectively new therapeutic strategies control tumor burden in humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10421378	Probiotic cells were suspended in the solution of a protective substance (5% trehalose) and fed to the dryer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Probiotic", "cells", ...
PMC11206251	On one hand, p53 is a tumor suppressor gene and the upstream factor of P21, which can induce apoptosis via the inhibition of cyclinD1 and CDK4 of HCC cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	For image acquisition and analysis, the ZEN 2009 software was used (Zeiss, New York, NY, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "image...
PMC11306019	The average adult intake of GA is estimated to be around 25 mg/day, based on studies of dietary consumption (Grosso et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	On the parallel approach, entire molecular set along with Camostat and Ambroxol were docked in the TMPRSS2 through ADV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "parallel", ...
PMC11380454	Indeed, Fig. 5A and D and Figure S3E show the dose-dependent inhibition of pNFκB expression by SAS and AS101 in B16/F10 melanoma cells (A), AML cells (D) and A549 cells (Fig. S3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11638255	Significance was calculated using two-tailed differential expression analysis using the MAST algorithm after batch correction with p-values displayed in figure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significance", "was", "calcu...
PMC11225860	Combination of Aurkin A plus alisertib disrupts alisertib induced polyploidy in a dose-dependent manner with associated increased apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combination", "of", "Aurkin", "A", "pl...
PMC9920575	As we mentioned before, many plant species have been shown to have antiproliferative effects by using high concentrations of extracts; however, A. atroviolaceum is among some of the notable exceptions with effectiveness at low concentrations but still requires an IC50 of 75 μg/mL to induce apoptosis in HeLa cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11472639	Table 1VariableSmouldering multiple myelomaMyeloma remissionTotal participants (n)94Male/Female (n/n)(4/5)(3/1)Ig light chain diagnosis (kappa/lambda)b(7/2)(3/1)Ig heavy chain diagnosis (IgG/IgA)b(8/1)(4/0)Age (years)60 ± 968 ± 6Height (cm)173.6 ± 8.3169.5 ± 10.1Body mass (kg)82.3 ± 25.775.6 ± 8.9Body mass index (kg⋅m)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	4-yr PFS and OS are 74% and 93% (Fig. 1B-C), with 3 deaths (n=1 each: sudden death, MDS, Richter’s syndrome).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11122631	Because only one predicted probability of compound 6 was 0.430, we suggested that future investigators might prioritize examining the possible effect of compound 6 on NO production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	b Mean normalized current amplitude of TRPV1 currents (nA) after treatment with 1 µM exendin 9–39 or 1 µM BCTC compared with the control, pH 5.5 (blue) (mean ± S.E.M.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11448304	Our combined analysis of transcriptomic, proteomic, and 2-hydroxyisobutyrylomic data offers a comprehensive view of the differences between radioresistant RA549 cells and the original A549 cell line at transcriptional, translational, and post-translational modification levels.. Both transcriptomic and proteomic data in...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLin...
PMC9545714	The skin measurement position was measured with a ruler in order to have the same position at each testing point.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "skin", "measurement",...
PMC9429973	The Day 1 mean plt, WBC and Hb values were 825x10/L (457-2220), 8.9x10/L (3.9-30.6), and 13.1 g/dL (9.4-16.5), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	RPMI-8226 cells were treated with HDAC6 inhibitors, cells were harvested in 20 mmol/L Tris pH 7.6, 25 mmol/L KCl, 10 mmol/L NaCl, 3 mmol/L MgCl2, 0.1 mmol/L ethylenediaminetetraacetic acid (EDTA), 10 mmol/L ATP, and 10% glycerol and lysed by freeze/thaw cycles.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	We further explored the differences of tumor immune microenvironment and targeted therapy based on the signature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "explored", "the", "differences", "of"...
PMC8481254	Single-guide RNAs targeting CDK19 were constructed by PCR with the primers listed in Supplementary Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-guide", "RNAs", "targeting", "CDK19", "were", "...
PMC11530949	The research findings suggest that Ag-doped CuO NPs can induce higher toxicity and apoptosis in cancer cells compared to Ephedra intermedia extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resea...
PMC11657744	In conclusion, our results demonstrate that a specific subset of DA proteins is indispensable for ciliary assembly, highlighting the complexity and specialization within the DA protein network in centriole function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503541	Further fractionation and analysis of F15-16 resulted in eight subfractions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "fractionation", "and", "analysis", "of", "F15", "-", "16", "resulted"...
PMC11473750	Scale bar: 100 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "μm", "." ] } ]
PMC10040136	It has been suggested that MSC may activate their PI3K-AKT-mTOR signaling pathway through paracrine secretion of TGF-2, thereby promoting the drug resistance of GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7519871	Significantly effective treatments compared to untreated control (shown as #) are indicated as *** (P<0.0005).Figure 3Cell survival fraction values as observed in HeLa in response to different doses of EGCG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC9429973	To close this diagnostic gap and to increase the yield of pathogen detection, NGS-based approaches were developed to detect cell-free DNA in plasma samples and evaluate the findings using elaborated mathematical algorithms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Cell viability was determined using the XTT assay (23).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "was", "determined", "using", "the", "XTT", "assay", "(", "23", ...
PMC10165258	First, a mask of the entire spheroid is obtained by combining 2 masks: one by applying an Otsu threshold (using a native Matlab function) on the green fluorescent image, and one obtained by thresholding the PI image.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A BRIDGE risk score calculator for predicting the study result is available online (47.94.162.105:8080/bridge/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "BRIDGE", "risk", "score", "calculator", "for", ...
PMC10988555	After 24 h, the culture medium was replaced with fresh medium (100 μL) containing 0.1–50 μM of the different complexes and incubated for 48 h in tumor cell lines or containing 0.1–100 μM of the different complexes and incubated for 48 h in fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	PLK1 plays a role in centrosome disjunction and separation and is highly expressed in human cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLK1", "plays", "a", "role", "in", "centrosome", ...
PMC9100622	Signal intensity quantification was measured with Image lab software (Bio-Rad).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Signal", "intensity", "quantification", "was", "measured", "with", "Image", "lab", ...
PMC7342409	The half maximal inhibitory concentration (IC50) was measured using the CCK-8 method to judge the sensitivity/resistance of the cell lines to imatinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11696576	KCN 4 N, H2O/THF 1:1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KCN", "4", "N", ",", "H2O/THF", "1:1", "." ] } ]
PMC11791203	Overall, literature indicates that 2,4-di-tert-butylphenol has promising anticancer effects and potential therapeutic applications in various diseases, making it a compound of interest for further research and development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	The small molecule BRAF inhibitor Vemurafenib has been reported to exhibit good initial clinical responses in treated patients, but the emergence of acquired Vemurafenib resistance ultimately leads to poor long-term efficacy.7 In general, the pathways thought to contribute to melanoma, and other kinase-driver tumor cel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6799808	3GLPT downregulates the expression of the antiapoptotic proteins Bcl-xL and survivin and upregulates the expression of DR4 and DR5, leading to activation of caspase 3/8 and cleavage of PARP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10898159	CS-1 and CS-2 are functioned as FTO inhibitors preventing KIT m6A mRNA demethylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CS-1", "and", "CS-2", "are", "functioned", "as", "FTO", "inhibitors", ...
PMC11371747	Representation as relative affinities for FRα relative to FA showed l-LV: 0.073, dl-LV: 0.041, d-LV: 0.016, and PLX: 0.0035 (Figure 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11363012	Plants synthesize valuable natural products that are widely used in the pharmaceutical, agrichemical, flavor, and fragrance industries.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plants", "synthesize", "valu...
PMC11650848	These scores help predict how likely a genetic variant is to be a regulatory variant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "scores", "help", "predict", "how", "likely", "a", ...
PMC10761218	The treatments were compared to controls (a negative sample without a test sample and a positive sample with the standard drug doxorubicin).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11792766	Target tissues such as liver and the intestinal epithelium are primary targets for food contaminants (Eskola et al., 2019; Pinton & Oswald, 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	Janković et al. (2022) recently reported a finalized study regarding the discovery of dual-active agents acting as anticancer and antiviral agents, which was based on the hybridization concept of “one drug curing two diseases” potentially being a successful tactic in healing patients who have cancer and the virus SARS-...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3730428	In addition, the BIR3 domain of XIAP can bind to and prevent homodimerization of caspase 9, thereby preventing its activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC9817179	In this work, we imaged various LLPS systems in living cells before and after PFA fixation, quantified parameters that describe LLPS appearance in cells, and showed that fixation can either enhance or diminish the apparent LLPS behaviors in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10798140	All NMR spectra were acquired in deuterated DMSO using a Bruker spectrometer at 500 MHz.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "NMR", "spectra", "were", "acquired", "in", "deuterat...
PMC11703896	Cancer cells exhibit reduced elongation and spreading, transforming to a round, shrunken morphology indicative of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "exhibit", "reduced", ...
PMC9693627	Western blot analyses were performed conventionally using following antibodies: anti-PTCD2 (NBP2-26176, Novusbio, Centennial, CO, USA), anti-MRPS27 (17280-1-AP, Proteintech, Manchester, UK), anti-MRPL44 (16394-1-AP, Proteintech, Manchester, UK), anti-Cox4 (11242-1-AP, Proteintech, Manchester, UK), anti-COII (55070-1-AP...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7369657	Antiapoptotic proteins, for instance Bcl-2 and Bcl-xL, inhibit cell death by binding and hindering proapoptotic proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiapoptotic", "proteins", ",", "for", ...
PMC11098378	Compared to control RNAi treatments, knockdown of RelA significantly increased VSV-M51R infection as expected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "to", "control", "RNAi", "treatments", ",", "kno...
PMC7022782	The physical stability of ICG-NPs1 in terms of particle size and PDI as a function of time and storing conditions is shown in Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10957991	Myoepithelial marker, p63, was detected with IF stainings from ctrl MCF10A and TRPV4-depleted MCF10A cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Myoepithelial", "marker", ",", ...
PMC9429973	Having a diverse editorial board can balance perspectives and reduce these biases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Having", "a", "diverse", "editorial", "board", "can", "balance", "perspectives", ...
PMC9100622	A673 (3.5 × 10 cells), TC71 (4 × 10 cells), and POE (6 × 10 cells) were seeded in flasks of 25 cm.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	No significant differences were found between multivessel CAD patients versus single vessel CAD patients regarding genotypes and alleles of XbaI (rs693), however non-significant higher frequency of X+X+ genotype were found in single vessel vs. multi-vessel CAD patients (12.8 vs. 8.4%; OR=0.645).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	Data were captured and analyzed using ForteBio Octet QKe system (ForteBio).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "captured", "and", "analyzed", "using", "ForteBio", "Octet",...
PMC11694066	A673 and SaOS-2 cells were cultured in DMEM, supplemented with 10% FBS.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A673", "and", "SaOS-2", "cells", "were", "cultured", ...
PMC11704834	As a ‘master’ regulator of lung cancer cell apoptosis resistance and EMT phenotype, it is hypothesized that inhibiting the TLE1 nuclear function can block its oncogenic function and its potential antagonistic effects on molecular targeted therapy including EGFR-TKI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A longer follow-up might be required to detect more subtle differences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "longer", "follow-up", "might", "be", "required", "to", "detect", "more", "subtle...
PMC10899471	Specifically, miR-939-3p is involved in the pathological processes of tumorigenesis and progression (37–39).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "miR-939", "-", "3...

PMC10854447

Calc. (%)

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Calc", ".", "(", "%", ")" ] } ]

PMC11746948

Paraffin sections were cut as described above and stained with hematoxylin and eosin using an automated H&E staining workstation (HistoCore SPECTRA, Leica).

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PMC11591030

However, treatment with LPS in combination with AOP, PDTC, or both (LPS + AOP, LPS + PDTC, LPS + PDTC + AOP) mitigated the overexpression of these genes challenged by LPS and increased the expression of the IkBα gene (p < 0.05).

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PMC11225860

At later stages of apoptosis, phosphatidylserine will be present, along with a high degree of cell membrane comprise, enabling the binding of both Annexin V and PI (double positive, C).

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PMC11172027

The use of 250 and 500 µg/mL after 72 h of incubation also showed no difference to the initial control.

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PMC11506827

The cells were then stained with 4′,6-diamidino-2-phenylindole, visualized using an ECLIPSE Ts2R inverted microscope (Nikon, Melville, NY, USA), and imaged using NIS-Elements BR software (Ver 4.00, Nikon).

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PMC11787355

In addition, PTPRZ1 was overexpressed in low-grade glioma (LGG) (Supplementary Fig. 1a), and its expression correlated positively with ABSOLUTE tumor purity (Supplementary Fig. 1b, c).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The latter activates TBK1 and IKK kinases that, in turn, activate IRF3 and NF-κB, which induce expression of interferons and other cytokines involved in anti-tumor immune responses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

L. Araujo de Albuquerque Simoes, I. Weinhäuser, D. A Pereira-Martins, C. A. Ortiz Rojas, T. Mantello Bianco, R. D. C. Cavaglieri, E. Magalhães Rego Center of Translational Research in Oncology, ICESP - Faculty of Medicine, USP, Sao Paulo; Center for Cell Based Therapy, Fundação Hemocentro de Ribeirão Preto, Ribeirão Pr...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10798140

C NMR (126 MHz, DMSO-d6) δ: 153.66, 152.81, 138.46, 137.70, 133.10, 130.37, 130.12, 126.70, 124.87, 123.61, 119.15, 114.84, 86.12, 65.94, 47.18.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11627398

Compared to low-LIAS or low-LIPT1 group, 149 and 142 pathways, respectively, including fatty acid metabolism, lipoic acid metabolism and carbon metabolism pathways, were enriched in high-LIAS or high-LIPT1 group (Fig 4C and 4D and S7 Table). (

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PMC11750712

For females who are not postmenopausal (<24 months of amenorrhea) or who are not surgically sterile (absence of ovaries and/or uterus), a highly effective method of contraception together with a barrier method must be used from the start of the preconditioning stage and for at least 12 months after the last dose of AUT...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10565698

In the transwell assay, the oe group showed enhanced migration and invasion compared to the nc group, but co-transfection with oe and miR-211-5p led to suppressive effects on these properties.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8316344

F Changes of iron did not influence apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Changes", "of", "iron", "did", "not", "influence", "apoptosis", "." ] } ]

PMC9429973

All data was extracted from electronical medical records.

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PMC5963610

Anti-EGFR antibody (Nimotuzumab) was registered in Cuba, for the treatment of several epithelial tumors mostly in combination with chemo or/and radiotherapy .

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PMC11506670

This suggests that the NRAS missense mutations may not have substantially altered the structure of the wild-type protein, which is expected of single nucleotide variations.

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PMC3734024

For B cell stimulation cultures, CD19 cells were added to a confluent layer of irradiated (30 Gy) CD40L-expressing fibroblasts in 24- or 96-well flat-bottomed culture plates in the presence or absence of 50 ng/mL recombinant mouse IL-5 and/or IL-4 (Peprotech Inc.).

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PMC11380454

We demonstrated that the tellurium(IV)-thiol chemical bond formed between AS101 and the α4-chain led to a conformational change in the VLA-4 integrin, preventing its interaction with its specific ligand and consequent signal transduction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4360730

Figure 1.Experimental metadata annotated with appropriate ontology terms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "1.Experimental", "metadata", "annotated", "with", "appropriate", "ontology", "terms", "." ] } ]

PMC11257988

KRAS status as a predictive biomarker for lung cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KRAS", "status", "as", "a", "predictive", "biomarker", "for", "lung", "cancer", "." ] } ]

PMC9429973

Thrombin generation and D-dimer showed no changes after mRNA vaccination compared with baseline.

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PMC11740508

In contrast, HRR intact cells have the ability to accurately repair damage during each S-Phase to maintain low damage levels and thus preserve viability.

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PMC9429973

All patients provided informed consent in accordance with an IRB-approved protocol and the Declaration of Helsinki.

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PMC5963610

Figure 1E indicates the experimental scheme.

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PMC11714165

n = 3.

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PMC10728535

Moreover, the human protein atlas (https://www.proteinatlas.org) and GeneCards (https://www.genecards.org) were used for further investigation of DEGs.

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PMC6222635

An adequate amount of the PPF and DPF was weighed and dissolved in distilled water to a fixed concentration of 1 mg/mL to obtain sample solutions.

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PMC8409415

The black bar indicates the median score of intensity.

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PMC11119602

The cell colonies collected from cisplatin-treated flasks were named HepG2/cr cells and the morphology of both cell lines was monitored using inverted phase contrast microscopy.

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PMC3203927

Three-dimensionality biomarkers would provide the intellectual basis for material discovery platform development.

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PMC11461833

Through subsequent experimental verification, we found that compared with that in empty vector-transfected of HEK293 cells, the expression of STXBP5 was upregulated in our progerin-expressing cell model.

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PMC7823217

Conventional 2D monolayer culture, monolayer co-culture, cells grown over floating membranes, and cell monolayer sandwiched between membranes, are the commonly used 2D cancer models in research and drug screening.

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PMC11583010

Female NOD/SCID/γc null (NSG) and male NMRI nude mice were obtained from Charles River Laboratories.

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PMC5925824

When tumors reached volumes of ~ 300 mm (~ 4–5 weeks), 2.5 × 10 expanded human T cells were administered intravenously (IV) and mice were treated with weekly IP injections of human IgG1 or LY3300054 at 10 mg/kg for a total of four doses.

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PMC11727062

These actions offer new insights and potential therapeutic strategies for melanoma treatment.

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PMC5810978

Another condition tested only for HuNoVs that resulted in a substantial increased HuNoV RNA level was the long-term (1 and 2 months) culturing of Caco-2 cells using the PEDV medium .

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PMC9429973

Given that α7nAChR transduces the cholinergic regulation of normal HSCs by BMSCs, we utilised LepR-Cre;Chrna7f/f mice to conditionally delete this signalling pathway in leukaemic mice.

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PMC11394112

Although traditional subcutaneous xenograft DLBCL mouse models allow for adequate drug discovery studies, the major limitation is the localized tumor growth in an often clinically non-relevant tissue that constrains the translation of how effectively new therapeutic strategies control tumor burden in humans.

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PMC10421378

Probiotic cells were suspended in the solution of a protective substance (5% trehalose) and fed to the dryer.

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PMC11206251

On one hand, p53 is a tumor suppressor gene and the upstream factor of P21, which can induce apoptosis via the inhibition of cyclinD1 and CDK4 of HCC cells .

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PMC9219615

For image acquisition and analysis, the ZEN 2009 software was used (Zeiss, New York, NY, USA).

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PMC11306019

The average adult intake of GA is estimated to be around 25 mg/day, based on studies of dietary consumption (Grosso et al., 2014).

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PMC8009078

On the parallel approach, entire molecular set along with Camostat and Ambroxol were docked in the TMPRSS2 through ADV.

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PMC11380454

Indeed, Fig. 5A and D and Figure S3E show the dose-dependent inhibition of pNFκB expression by SAS and AS101 in B16/F10 melanoma cells (A), AML cells (D) and A549 cells (Fig. S3E).

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PMC11638255

Significance was calculated using two-tailed differential expression analysis using the MAST algorithm after batch correction with p-values displayed in figure.

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PMC11225860

Combination of Aurkin A plus alisertib disrupts alisertib induced polyploidy in a dose-dependent manner with associated increased apoptosis.

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PMC9920575

As we mentioned before, many plant species have been shown to have antiproliferative effects by using high concentrations of extracts; however, A. atroviolaceum is among some of the notable exceptions with effectiveness at low concentrations but still requires an IC50 of 75 μg/mL to induce apoptosis in HeLa cells .

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PMC11472639

Table 1VariableSmouldering multiple myelomaMyeloma remissionTotal participants (n)94Male/Female (n/n)(4/5)(3/1)Ig light chain diagnosis (kappa/lambda)b(7/2)(3/1)Ig heavy chain diagnosis (IgG/IgA)b(8/1)(4/0)Age (years)60 ± 968 ± 6Height (cm)173.6 ± 8.3169.5 ± 10.1Body mass (kg)82.3 ± 25.775.6 ± 8.9Body mass index (kg⋅m)...

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PMC9429973

4-yr PFS and OS are 74% and 93% (Fig. 1B-C), with 3 deaths (n=1 each: sudden death, MDS, Richter’s syndrome).

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PMC11122631

Because only one predicted probability of compound 6 was 0.430, we suggested that future investigators might prioritize examining the possible effect of compound 6 on NO production.

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PMC11612315

b Mean normalized current amplitude of TRPV1 currents (nA) after treatment with 1 µM exendin 9–39 or 1 µM BCTC compared with the control, pH 5.5 (blue) (mean ± S.E.M.).

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PMC11448304

Our combined analysis of transcriptomic, proteomic, and 2-hydroxyisobutyrylomic data offers a comprehensive view of the differences between radioresistant RA549 cells and the original A549 cell line at transcriptional, translational, and post-translational modification levels.. Both transcriptomic and proteomic data in...

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PMC9545714

The skin measurement position was measured with a ruler in order to have the same position at each testing point.

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PMC9429973

The Day 1 mean plt, WBC and Hb values were 825x10/L (457-2220), 8.9x10/L (3.9-30.6), and 13.1 g/dL (9.4-16.5), respectively.

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PMC11188874

RPMI-8226 cells were treated with HDAC6 inhibitors, cells were harvested in 20 mmol/L Tris pH 7.6, 25 mmol/L KCl, 10 mmol/L NaCl, 3 mmol/L MgCl2, 0.1 mmol/L ethylenediaminetetraacetic acid (EDTA), 10 mmol/L ATP, and 10% glycerol and lysed by freeze/thaw cycles.

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PMC11697189

We further explored the differences of tumor immune microenvironment and targeted therapy based on the signature.

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PMC8481254

Single-guide RNAs targeting CDK19 were constructed by PCR with the primers listed in Supplementary Table S1.

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PMC11530949

The research findings suggest that Ag-doped CuO NPs can induce higher toxicity and apoptosis in cancer cells compared to Ephedra intermedia extract.

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PMC11657744

In conclusion, our results demonstrate that a specific subset of DA proteins is indispensable for ciliary assembly, highlighting the complexity and specialization within the DA protein network in centriole function.

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PMC9503541

Further fractionation and analysis of F15-16 resulted in eight subfractions.

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PMC11473750

Scale bar: 100 μm.

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PMC10040136

It has been suggested that MSC may activate their PI3K-AKT-mTOR signaling pathway through paracrine secretion of TGF-2, thereby promoting the drug resistance of GIST.

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PMC7519871

Significantly effective treatments compared to untreated control (shown as #) are indicated as *** (P<0.0005).Figure 3Cell survival fraction values as observed in HeLa in response to different doses of EGCG.

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PMC9429973

To close this diagnostic gap and to increase the yield of pathogen detection, NGS-based approaches were developed to detect cell-free DNA in plasma samples and evaluate the findings using elaborated mathematical algorithms.

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PMC11188874

Cell viability was determined using the XTT assay (23).

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PMC10165258

First, a mask of the entire spheroid is obtained by combining 2 masks: one by applying an Otsu threshold (using a native Matlab function) on the green fluorescent image, and one obtained by thresholding the PI image.

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PMC9429973

A BRIDGE risk score calculator for predicting the study result is available online (47.94.162.105:8080/bridge/).

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PMC10988555

After 24 h, the culture medium was replaced with fresh medium (100 μL) containing 0.1–50 μM of the different complexes and incubated for 48 h in tumor cell lines or containing 0.1–100 μM of the different complexes and incubated for 48 h in fibroblasts.

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PMC6600253

PLK1 plays a role in centrosome disjunction and separation and is highly expressed in human cancers.

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PMC9100622

Signal intensity quantification was measured with Image lab software (Bio-Rad).

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PMC7342409

The half maximal inhibitory concentration (IC50) was measured using the CCK-8 method to judge the sensitivity/resistance of the cell lines to imatinib.

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PMC11696576

KCN 4 N, H2O/THF 1:1.

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PMC11791203

Overall, literature indicates that 2,4-di-tert-butylphenol has promising anticancer effects and potential therapeutic applications in various diseases, making it a compound of interest for further research and development.

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PMC11552389

The small molecule BRAF inhibitor Vemurafenib has been reported to exhibit good initial clinical responses in treated patients, but the emergence of acquired Vemurafenib resistance ultimately leads to poor long-term efficacy.7 In general, the pathways thought to contribute to melanoma, and other kinase-driver tumor cel...

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PMC6799808

3GLPT downregulates the expression of the antiapoptotic proteins Bcl-xL and survivin and upregulates the expression of DR4 and DR5, leading to activation of caspase 3/8 and cleavage of PARP.

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PMC10898159

CS-1 and CS-2 are functioned as FTO inhibitors preventing KIT m6A mRNA demethylation.

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PMC11371747

Representation as relative affinities for FRα relative to FA showed l-LV: 0.073, dl-LV: 0.041, d-LV: 0.016, and PLX: 0.0035 (Figure 2B).

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PMC11363012

Plants synthesize valuable natural products that are widely used in the pharmaceutical, agrichemical, flavor, and fragrance industries.

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PMC11650848

These scores help predict how likely a genetic variant is to be a regulatory variant.

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PMC10761218

The treatments were compared to controls (a negative sample without a test sample and a positive sample with the standard drug doxorubicin).

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PMC11792766

Target tissues such as liver and the intestinal epithelium are primary targets for food contaminants (Eskola et al., 2019; Pinton & Oswald, 2014).

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PMC10747139

Janković et al. (2022) recently reported a finalized study regarding the discovery of dual-active agents acting as anticancer and antiviral agents, which was based on the hybridization concept of “one drug curing two diseases” potentially being a successful tactic in healing patients who have cancer and the virus SARS-...

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PMC3730428

In addition, the BIR3 domain of XIAP can bind to and prevent homodimerization of caspase 9, thereby preventing its activation.

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PMC9817179

In this work, we imaged various LLPS systems in living cells before and after PFA fixation, quantified parameters that describe LLPS appearance in cells, and showed that fixation can either enhance or diminish the apparent LLPS behaviors in vivo.

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PMC10798140

All NMR spectra were acquired in deuterated DMSO using a Bruker spectrometer at 500 MHz.

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PMC11703896

Cancer cells exhibit reduced elongation and spreading, transforming to a round, shrunken morphology indicative of apoptosis.

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PMC9693627

Western blot analyses were performed conventionally using following antibodies: anti-PTCD2 (NBP2-26176, Novusbio, Centennial, CO, USA), anti-MRPS27 (17280-1-AP, Proteintech, Manchester, UK), anti-MRPL44 (16394-1-AP, Proteintech, Manchester, UK), anti-Cox4 (11242-1-AP, Proteintech, Manchester, UK), anti-COII (55070-1-AP...

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PMC7369657

Antiapoptotic proteins, for instance Bcl-2 and Bcl-xL, inhibit cell death by binding and hindering proapoptotic proteins.

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PMC11098378

Compared to control RNAi treatments, knockdown of RelA significantly increased VSV-M51R infection as expected.

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PMC7022782

The physical stability of ICG-NPs1 in terms of particle size and PDI as a function of time and storing conditions is shown in Figure 1.

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PMC10957991

Myoepithelial marker, p63, was detected with IF stainings from ctrl MCF10A and TRPV4-depleted MCF10A cell lines.

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PMC9429973

Having a diverse editorial board can balance perspectives and reduce these biases.

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PMC9100622

A673 (3.5 × 10 cells), TC71 (4 × 10 cells), and POE (6 × 10 cells) were seeded in flasks of 25 cm.

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PMC9429973

No significant differences were found between multivessel CAD patients versus single vessel CAD patients regarding genotypes and alleles of XbaI (rs693), however non-significant higher frequency of X+X+ genotype were found in single vessel vs. multi-vessel CAD patients (12.8 vs. 8.4%; OR=0.645).

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PMC10237474

Data were captured and analyzed using ForteBio Octet QKe system (ForteBio).

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PMC11694066

A673 and SaOS-2 cells were cultured in DMEM, supplemented with 10% FBS.

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PMC11704834

As a ‘master’ regulator of lung cancer cell apoptosis resistance and EMT phenotype, it is hypothesized that inhibiting the TLE1 nuclear function can block its oncogenic function and its potential antagonistic effects on molecular targeted therapy including EGFR-TKI.

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PMC9429973

A longer follow-up might be required to detect more subtle differences.

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PMC10899471

Specifically, miR-939-3p is involved in the pathological processes of tumorigenesis and progression (37–39).

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