OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11394227	The HsQSOX1b protein, fused with the EGFP protein and the ER localization sequence KDEL, exhibited green fluorescence and a dark nucleus (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	CancerSEA database analyzes functions of key genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CancerSEA", "database", "analyzes", "functions", "of", "key", "genes", "." ] } ]
PMC11714165	The concentration of peptide was 1 mM. Over the 10‐day period following the initial injection, the circumference of the tumor‐bearing limbs of the mice were measured every 3 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	OTULIN, a specific linear deubiquitinating enzyme, primarily regulates the linear ubiquitin modification of target proteins, thereby affecting their function .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OTULIN", ","...
PMC11767793	Iscove’s Modified Dulbecco’s Medium (IMDM) and Roswell Park Memorial Institute (RPMI) medium were sourced from Life Technologies (Grand Island, NY, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Thirty-three of 35 patients completed Year 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Thirty-three", "of", "35", "patients", "completed", "Year", "2", "." ] } ]
PMC11736898	Scratch wounds were created by scratching the monolayers with a sterile 200 μl pipet tip, and each well was rinsed twice prior to incubation in culture medium supplemented with 0 or 100 nM vitamin D, combined with 0 or 10 μM ketoconazole or 0 or 100 nM VID400, for 24 h. Circles were etched on the underside of each well...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699465	Further exploration should focus on this point.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "exploration", "should", "focus", "on", "this", "point", "." ] } ]
PMC11343332	Cells were starved for three hours at 37°C in serum-free media after being washed twice with 100 µl of serum-free medium 24 hours after plating.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629143	Four single‐guide RNAs (sgRNAs 1–4) targeting the CMV promoter were designed with the Benchling guide RNA tool (https://benchling.com) (Table 1) and cloned into the pSpgRNA plasmid (Addgene 47108), as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11209164	Consistent with our previous findings with DMF , TPF significantly increased the infectivity of VSVΔ51 at a low MOI of 0.01, compared to a high MOI of 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	HES6, on the other hand, does not seem to be Notch dependent and has been poorly studied in the hematopoietic system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HES6", ...
PMC7351993	These cell types were chosen to be able to check the sorting performance of the RIACS with fluorescence microscopy (as a ground truth provider).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The pathogen basis could not be found through blood culture and humoral culture, and the pathogenic microorganisms were submitted for NGS examination to analyze the pathogenic microorganisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10538569	These data indicate that CEMss-CCR5-CR2N cells resist trans-infection by iDC-captured HIV-1 Yu-2.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "indicate", "that", "CEMss-CCR5-CR2N", "cells", "resist", "tr...
PMC10604092	Initially, we measured the rats’ body weight and food intake to investigate the effects of subcutaneous SLC transplantation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initially", ",", "we", ...
PMC11519567	two-sided, unpaired t test; n = 20 condensates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "two-sided", ",", "unpaired", "t", "test", ";", "n", "=", "20", "condensates", "." ] ...
PMC11283030	The results showed that multiple immunoinhibitors including kinase insert domain receptor (KDR, rho = 0.390, P < 0.001), CD274 (PD-L1, rho = 0.218, P < 0.001), and programmed cell death protein 1 ligand 2 (PDCD1LG2, or PD-L2, rho = 0.141, P = 0.001) were significantly associated with ACLY in ccRCC, while PDCD1 (PD-1) w...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759751	Effects of different concentrations of chidamine on proliferation multiple and survival rate of CD19 CAR T cells in preparation (B, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC3019555	Therefore, inhibition of HIF-1α represents an attractive strategy for anticancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "inhibition", "of", "HIF-1α", "represents", "an", "attractive", ...
PMC11610461	The extracted RNA was reverse transcribed into cDNA using PrimeScript™ RT reagent Kit (TaKaRa Bio, Beijing, China) (Tang et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600592	Therapies of hepatitis B infection currently include methods of direct-acting antivirals (just as with nucleoside analogs) and host-targeting antivirals (just as with interferon) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7961460	Transfection of MCF-7 human breast cancer cells were performed using a Nucleofector Apparatus (Amaxa) and the Cell Line Nucleofector™ Kit V (Lonza).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10218459	The solutions were further diluted 1:100 in full medium before being administered to the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solutions", "were", "further", "diluted", "1:100", "...
PMC7642379	Total RNA was extracted from three replicates of each cell line using Qiagen’s RNeasy plus Mini Kit according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8973085	White solid [A] (89%); [B] (75%); mp: 175–178 °C (EtOH); IR (KBr, v, cm): 3481–3311 (NH2), 3260 (NH), 1730 (C=O), 1674 (C=O); H NMR (DMSO-d6): δ 1.30 (t, 3H, CH3), 2.55 (s, 3H, CH3), 3.65 (s, 3H, OCH3), 3.70 (s, 3H, OCH3), 4.24 (q, 2H, CH2), 6.90–7.44 (m, 9H, 7CH-Ar + NH2), 10.37 (bs, 1H, NH); C NMR (DMSO-d6): δ 13.89,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	The metabolic products of coumarin (7-hydroxycoumarin, assay for CYP2A6 activities), bupropion (hydroxybupropion, assay for CYP2B6 activity), diclofenac (4-hydroxydiclofenac, assay for CYP2C9 activity), chlorzoxazone (6-hydroxychlorzoxazone, assay for CYP2E1 activity) and midazolam (1-hydroxymidazolam, assay for CYP3A4...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Female C57BL/6J mice were injected with 5 × 10 MC38 cells subcutaneously in the right leg.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Female", "C57BL/6J", "mice", "were", "inje...
PMC11746948	The constitution was then centrifuged at 16,200 × g for 15 min at 4 °C, and 85 μl of supernatant was transferred to a fresh glass vial for LC/MS analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	The average BLI signal for all the groups was the same at start of treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "BLI", "signal", "for", "all", "the", ...
PMC11732628	Moreover, research has also shown that miR-490-3p expression is reduced in osteosarcoma cell lines, and miR-490-3p upregulation can inhibit osteosarcoma cell proliferation, induce G1 arrest, and facilitate cell apoptosis (25).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median age of patients was 51 years (range 28-87 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "of", "patients", "was", "51", ...
PMC11754436	In the DHRS4-AS1 + miR-362-5p mimic group (D + mm), both DHRS4-AS1 and miR-362-5p were overexpressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11401350	Fortunately, preclinical mouse models for AITL are now finally available [11–14, 44].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fortunately", ",", "preclinical", "mouse", "models", "...
PMC9429973	Notably, there is little information available regarding the associated tumor microenvironment (TME) of AL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "there", "is", "little", "in...
PMC11286266	Figure 1—figure supplement 4.FURIN depletion decreases responsiveness to ATF6α activation upon endoplasmic reticulum (ER) stress.(A) Two-dimensional contour plots of BiP::sfGFP and XBP1s::mCherry signals in a sorted pooled population with FURIN depletion through CRISPR/Cas9 sgRNAs targeting exons 4 and 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Besides, low ALC at diagnosis identified 9 patients within the low IPI group who did not achieve CR (p=0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",...
PMC11457557	In contrary, in polygenic diabetic subgroups, and notably in T2DM, subgroup recognition is difficult, and indications for patient therapy are generally absent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11585587	After obtaining the intersection of genes, the DAVID database(https://david.ncifcrf.gov/) was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for target gene function and pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Cells were gently resuspended with care to avoid clumps and then 50 μl of the resuspended cells were added to an Eppendorf tube.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC9429973	Results: Median age of patients was 81 months (10-263 months), female/male ratio was 1.1 (69/60), donor types MUD 72 patients (56%), MSD 50 patients (39%), and MFD 7 patients (5%) was detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	The nuclear nonhistone protein Ki-67 acts as a surfactant to form a repulsive molecular brush around fully condensed sister chromatids in early mitosis, preventing the diffusion or penetration of nuclear lipids into intrachromosomal regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11119602	When the TG2 protein sequence (accession n. P21980) was scanned for potential functional sites using the Eukaryotic Linear Motif (ELM) prediction server, several validated interaction sites and putative short linear motifs (SLiMs) based on the primary amino acid sequence of TG2-L were detected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	Immunolabeling for MAPK8 and GFP reveals an increase in the number of MAPK8+ neurons in cultures transfected with antisense miR-193b and antisense miR-365 compared to control cultures transfected with scrambled-miRNA (Figure 2F; Scram controls 17%, miR-193b-AS 46%, miR-365-AS 56%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	In contrast, an increase in expression of the p53 mutant (in OVCAR-3 and SKOV-3 cells) may be ineffective in triggering apoptotic processes due to the dysfunction of the mutant protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9895440	Specific lysis was calculated as above (killing assay).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specific", "lysis", "was", "calculated", "as", "above", "(", "killing", "assay", ")", "." ...
PMC11708541	All IN produced action potential bursts synchronized with the field potential trials that caused SLE termination as the condition progressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "IN", "produced", ...
PMC4112127	After shaking on a plate shaker for 3 hours at room temperature, fluorescence was measured at an excitation wavelength of 485 nm and emission wavelength of 520 nm on an FLx800 Microplate Fluorescence Reader (BIO-TEK Instruments Inc., Winooski, VT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	For the recording of dose-response curves the following protocol was used: first, the baseline-BRET was recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "recording", "of", "dose-...
PMC10734950	This screen revealed a novel thiophene, F8 (methyl 5-[(dimethylamino)carbonyl]-4-methyl-2-[(3-phenyl-2-propynoyl) amino]-3-thiophenecarboxylate), that displays anti-cancer activity on lymphoma, leukemia, and other cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3888431	Nevertheless, 17,883 homologs of mouse genes and 19,500 homologs of rat genes were identified by this approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "17,883", "homologs", ...
PMC10547921	Figure 20Design of carmaphycins analogs 114–122.Figure 20 Design of carmaphycins analogs 114–122.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "20Design", "of", "carmaphycins", "analogs", "114–122.Figure", "20", "Design"...
PMC8567602	The same approaches of co-IP and glycerol gradients of nuclear extracts were tested in mouse tumors, using combination genotype tumors with genetically silenced Smarcb1 as a negative control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8956657	The MERS ORF4b NLS region peptide spans residues 19–39 and contains a FITC and Ahx linker (middle panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MERS", "ORF4b", ...
PMC11788920	On the other hand, we observed dCas9 stall in only one of the three cases (RNP1 but not RNP6 or RNP7) when dCas9 targeted the TS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640555	Additionally, the caspase 3 level was increased only by the higher concentration of CX-4945, the 15 μM, 24 h after treatment (Figure 3I, densitometric analysis Figure 3(I1)), when compared to the 5 and 10 μM concentrations, which were not effective in activating apoptosis (Figure 3I, densitometric analysis Figure 3(I1)...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	Some Figures were created with BioRender.com.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "Figures", "were", "created", "with", "BioRender.com", "." ] } ]
PMC11127909	G The apoptosis rate is shown in bar charts, N = 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "The", "apoptosis", "rate", "is", "shown", "in", "bar", "charts",...
PMC10723784	Representative data indicating the concentration response curves to CBD when cells were allowed to recover from exposure to CBD compared to when cells were in continuous contact with cannabinoids prior to the MTT assay over different contact times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503541	Centroid and profile data were selected for the MS1 and MS/MS data types, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centroid", "and", "profile", "data", "were", "selected", "f...
PMC9019892	Considering the well‐documented safety and pharmacokinetic profiles of nintedanib, this finding provides evidence for the repurposing of nintedanib as a new therapy for the treatment of GIST patients with de novo or acquired resistance to imatinib.fibroblast growth factors FGFR substrate 2 gastrointestinal stromal tumo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In addition, ratios of 0% without indication of sensitivity were allocated as MR4 i.e. 0.01%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "ratios", "of", ...
PMC11545737	The latter includes (i) programmed cell death, necessary for development or tissue turnover that does not rely on any exogenous stimuli and (ii) diverse forms of RCD that the cell activates depending on the stimuli received.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545474	Her research activities focus on the design of polymers used as cargo to carry organometallic complexes for medical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Her", "research", "activities", "...
PMC11535726	Asexual morph: Colonies on the natural substrate superficial, effuse, scattered, hairy, black, glistening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Asexual", "morph", ":", "Colonies...
PMC9429973	More than one site extranodal involvement with lung or adrenal lesions increasing overall and early RR correspondingly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "than", "one", "site", "extranodal", ...
PMC10729469	After four trials (T1-T4) the mice were returned their cages for 30 min and reintroduced into the T4 arm for the delayed retention trial (T5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	The features associated with boundaries separating A and B compartments calculated from Hi-C eigenvectors have not been studied to our knowledge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "features", ...
PMC11704834	P<0.05 was considered to indicate a statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P<0.05", "was", "considered", "to", "indicate", "a", "statistically", "significant", "difference", "." ...
PMC2196094	The typical CTMC proteases RMCP-1, -5, -6, and CPA were found at very high frequencies in the serosal MC library, whereas a low number of, or a total lack of clones for the MMC proteases RMCP-2, -3, -4, and the members of the RMCP-8 family were detected in the same library.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742231	Additionally, it addresses the issue of disregarding the significant interactions between atoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "it", "addresses", "the", "issue", "of", "disregarding"...
PMC10748106	In Table 5 are listed some descriptors related to the reactivity, solubility, shape, and size of active iridoid glycosides and Geniposide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11585565	Crude protein lysates were extracted by suspending the cell pellet in radio-immunoprecipitation assay (RIPA) buffer (50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1 mM EDTA, 0.1% (w/v) SDS, 0.25% (w/v) sodium deoxycholate, 1% (V/V) NP-40 and 1x protease inhibitor cocktail (Thermo Scientific)) on ice for 10 min before centrifugat...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	Lack of physical resources (e.g. limited space in cat cage due to the small size of cage, insufficient bedding supplies) was one of the barriers experienced by participants (n = 14/20) to having proper practice management for cat patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	Thus, when analyzing cell samples treated with compound 9a at concentrations of CC50 and 0.5CC50, a pronounced increase in caspases 9, 8, and JNK in the first 6 h of incubation is observed, which is a reliable indicator that the new hybrid molecule induces apoptosis in Jurkat cells via a p53-independent pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10197932	In this general framework, Pappalettere et al. 10,6 tested the application of low-intensity US on U937 human myelomonocytic cells comparing the effects, in terms of rate of survival, when operating at fixed frequency rather than sweeping.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	The damage causes further and rapid destruction in internal organs, and eventually leads to limb amputations, organ failure, and even death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11767725	High-resolution, longitudinal studies integrating multi-omics datasets will be essential to elucidate host–microbiome dynamics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High-resolution", ",", "longitudinal", "studies", "integrati...
PMC9275501	Then, the extracted TE10 cell membrane and DSPE-PEG were self-assembled to wrap the drug-loaded PLGA NPs, so that the drug carrier had homologous targeting function, significantly improved the drug concentration of the target site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11597167	Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a common flavonoid derivative with marked biological activities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quercetin", "(", "3,3′,4′,5,7-pentahydroxyflavone", ")", "is", "a", "common", ...
PMC10667689	Cell lines were stimulated with 50 ng of PMA (PeproTech, USA) final concentration, for 24 h. FITC anti-human CD366 [(TIM-3); clone: F38-2E2, isotype: Mouse IgG1, κ] (BioLegend, USA) was used to stain stimulated cells vs. control cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11641630	However, statistically significant differences were seen in intermediate-grade 5637 and low-grade SW780 cells when they were infected with mycobacteria (Figure 1B,C and Supplementary File).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11638764	Additionally, a key protein in the autophagy pathway, ATG5, showed downregulation in the CER compartment with a log2 fold change of -2.9 and significant upregulation in the INS compartment with a log2 fold change of 6.8 ( Fig. 1H ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7452526	After incubation time, 20 μl of MTT (5 mg/mL) was added and the cells were incubated again for another 4 hrs at 37 °C in CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5716223	Viability was evaluated by trypan blue exclusion assay performed at the same culture conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viability", "was", "evaluated", "by", "trypan", "blue", "exclusion", ...
PMC9436459	Morusalbin C (49), the first non-ketalized MDAAs with an aromatic ring instead of cyclohexene ring, was recently identified from M. alba .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11201989	The speculated partner may probably be a motor protein that concentrates PD-L1 at the site, rather than a permanent component of the centrosome because the endogenous localization of PD-L1 is affected by the disruption of microtubules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604768	GPCRs were clustered using Euclidean distance with complete linkage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPCRs", "were", "clustered", "using", "Euclidean", "distance", "with", "complete", "linkage", "." ] }...
PMC11448304	Fig. 3Proteomic data on A549 and RA549.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "Fig.", "3Proteomic", "data", "on", "A549", "and", "RA549", "." ] } ]
PMC11477621	The crude product was purified by silica gel chromatography to give the colorless oil 4i (829 mg, 77%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "crude...
PMC9429973	All patients had bulky disease > 7cm, B symptoms and Stage ≥2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "patients", "had", "bulky", "disease", ">", "7", "cm", ...
PMC10850553	The deposition of complement C3, C5 or C5b-9 complex in the kidney from the anti-Thy1.1-induced glomerulonephritis model of rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "deposition", "of", ...
PMC11627133	To validate the feasibility of this approach, we first determined the kinetic rate coefficients of the bifunctional AP3‐RhoBAST and SpyRho using stopped‐flow kinetic measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11574271	F T24 cells were transfected with LV-miR-659-3p to create T24-659-3p cells, which were subsequently transfected with lentivirus overexpressing RON to generate T24-659-3p-RON cells.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", ...
PMC11477621	Drawing inspiration from the structural resemblance between a natural product N-(3-carboxypropyl)-2-acetylpyrrole and phenylbutyric acid, a pioneer HDAC inhibitor evaluated in clinical trials, we embarked on the design and synthesis of a novel array of HDAC inhibitors containing an N-linked 2-acetylpyrrole cap by utili...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	We revealed that the soft 3D CS microenvironment results in reducing mitochondrial function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "revealed", "that", "the", "soft", "3D", "CS", "microenvironment", ...
PMC7433824	Detoxification of reactive oxygen species, cellular response to stress, glucose metabolism, and immunity‐related proteins were altered in P4‐treated GBM cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11422497	C-D) RT-qPCR analysis demonstrating the downregulation of miR-494-3p in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	However, reviewing the results of the alterations in the alpha genes in our laboratory, we have observed that triplications are not as infrequent as previously thought, either alone or associated with β-thalassemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	White bar equals 75 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "White", "bar", "equals", "75", "μm", "." ] } ]

PMC11394227

The HsQSOX1b protein, fused with the EGFP protein and the ER localization sequence KDEL, exhibited green fluorescence and a dark nucleus (Figure 1B).

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PMC11659921

CancerSEA database analyzes functions of key genes.

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PMC11714165

The concentration of peptide was 1 mM. Over the 10‐day period following the initial injection, the circumference of the tumor‐bearing limbs of the mice were measured every 3 days.

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PMC11670407

OTULIN, a specific linear deubiquitinating enzyme, primarily regulates the linear ubiquitin modification of target proteins, thereby affecting their function .

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PMC11767793

Iscove’s Modified Dulbecco’s Medium (IMDM) and Roswell Park Memorial Institute (RPMI) medium were sourced from Life Technologies (Grand Island, NY, USA).

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PMC9429973

Results: Thirty-three of 35 patients completed Year 2.

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PMC11736898

Scratch wounds were created by scratching the monolayers with a sterile 200 μl pipet tip, and each well was rinsed twice prior to incubation in culture medium supplemented with 0 or 100 nM vitamin D, combined with 0 or 10 μM ketoconazole or 0 or 100 nM VID400, for 24 h. Circles were etched on the underside of each well...

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PMC11699465

Further exploration should focus on this point.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "exploration", "should", "focus", "on", "this", "point", "." ] } ]

PMC11343332

Cells were starved for three hours at 37°C in serum-free media after being washed twice with 100 µl of serum-free medium 24 hours after plating.

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PMC11629143

Four single‐guide RNAs (sgRNAs 1–4) targeting the CMV promoter were designed with the Benchling guide RNA tool (https://benchling.com) (Table 1) and cloned into the pSpgRNA plasmid (Addgene 47108), as previously described .

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PMC11209164

Consistent with our previous findings with DMF , TPF significantly increased the infectivity of VSVΔ51 at a low MOI of 0.01, compared to a high MOI of 1.

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PMC9429973

HES6, on the other hand, does not seem to be Notch dependent and has been poorly studied in the hematopoietic system.

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PMC7351993

These cell types were chosen to be able to check the sorting performance of the RIACS with fluorescence microscopy (as a ground truth provider).

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PMC9429973

The pathogen basis could not be found through blood culture and humoral culture, and the pathogenic microorganisms were submitted for NGS examination to analyze the pathogenic microorganisms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10538569

These data indicate that CEMss-CCR5-CR2N cells resist trans-infection by iDC-captured HIV-1 Yu-2.

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PMC10604092

Initially, we measured the rats’ body weight and food intake to investigate the effects of subcutaneous SLC transplantation.

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PMC11519567

two-sided, unpaired t test; n = 20 condensates.

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PMC11283030

The results showed that multiple immunoinhibitors including kinase insert domain receptor (KDR, rho = 0.390, P < 0.001), CD274 (PD-L1, rho = 0.218, P < 0.001), and programmed cell death protein 1 ligand 2 (PDCD1LG2, or PD-L2, rho = 0.141, P = 0.001) were significantly associated with ACLY in ccRCC, while PDCD1 (PD-1) w...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11759751

Effects of different concentrations of chidamine on proliferation multiple and survival rate of CD19 CAR T cells in preparation (B, C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC3019555

Therefore, inhibition of HIF-1α represents an attractive strategy for anticancer therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "inhibition", "of", "HIF-1α", "represents", "an", "attractive", ...

PMC11610461

The extracted RNA was reverse transcribed into cDNA using PrimeScript™ RT reagent Kit (TaKaRa Bio, Beijing, China) (Tang et al., 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6600592

Therapies of hepatitis B infection currently include methods of direct-acting antivirals (just as with nucleoside analogs) and host-targeting antivirals (just as with interferon) .

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PMC7961460

Transfection of MCF-7 human breast cancer cells were performed using a Nucleofector Apparatus (Amaxa) and the Cell Line Nucleofector™ Kit V (Lonza).

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PMC10218459

The solutions were further diluted 1:100 in full medium before being administered to the cells.

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PMC7642379

Total RNA was extracted from three replicates of each cell line using Qiagen’s RNeasy plus Mini Kit according to the manufacturer’s instructions.

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PMC8973085

White solid [A] (89%); [B] (75%); mp: 175–178 °C (EtOH); IR (KBr, v, cm): 3481–3311 (NH2), 3260 (NH), 1730 (C=O), 1674 (C=O); H NMR (DMSO-d6): δ 1.30 (t, 3H, CH3), 2.55 (s, 3H, CH3), 3.65 (s, 3H, OCH3), 3.70 (s, 3H, OCH3), 4.24 (q, 2H, CH2), 6.90–7.44 (m, 9H, 7CH-Ar + NH2), 10.37 (bs, 1H, NH); C NMR (DMSO-d6): δ 13.89,...

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PMC10114490

The metabolic products of coumarin (7-hydroxycoumarin, assay for CYP2A6 activities), bupropion (hydroxybupropion, assay for CYP2B6 activity), diclofenac (4-hydroxydiclofenac, assay for CYP2C9 activity), chlorzoxazone (6-hydroxychlorzoxazone, assay for CYP2E1 activity) and midazolam (1-hydroxymidazolam, assay for CYP3A4...

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PMC11770199

Female C57BL/6J mice were injected with 5 × 10 MC38 cells subcutaneously in the right leg.

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PMC11746948

The constitution was then centrifuged at 16,200 × g for 15 min at 4 °C, and 85 μl of supernatant was transferred to a fresh glass vial for LC/MS analysis.

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PMC10079526

The average BLI signal for all the groups was the same at start of treatment.

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PMC11732628

Moreover, research has also shown that miR-490-3p expression is reduced in osteosarcoma cell lines, and miR-490-3p upregulation can inhibit osteosarcoma cell proliferation, induce G1 arrest, and facilitate cell apoptosis (25).

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PMC9429973

The median age of patients was 51 years (range 28-87 years).

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PMC11754436

In the DHRS4-AS1 + miR-362-5p mimic group (D + mm), both DHRS4-AS1 and miR-362-5p were overexpressed.

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PMC11401350

Fortunately, preclinical mouse models for AITL are now finally available [11–14, 44].

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PMC9429973

Notably, there is little information available regarding the associated tumor microenvironment (TME) of AL.

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PMC11286266

Figure 1—figure supplement 4.FURIN depletion decreases responsiveness to ATF6α activation upon endoplasmic reticulum (ER) stress.(A) Two-dimensional contour plots of BiP::sfGFP and XBP1s::mCherry signals in a sorted pooled population with FURIN depletion through CRISPR/Cas9 sgRNAs targeting exons 4 and 10.

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PMC9429973

Besides, low ALC at diagnosis identified 9 patients within the low IPI group who did not achieve CR (p=0.001).

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PMC11457557

In contrary, in polygenic diabetic subgroups, and notably in T2DM, subgroup recognition is difficult, and indications for patient therapy are generally absent.

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PMC11585587

After obtaining the intersection of genes, the DAVID database(https://david.ncifcrf.gov/) was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses for target gene function and pathways.

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PMC11489351

Cells were gently resuspended with care to avoid clumps and then 50 μl of the resuspended cells were added to an Eppendorf tube.

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PMC9429973

Results: Median age of patients was 81 months (10-263 months), female/male ratio was 1.1 (69/60), donor types MUD 72 patients (56%), MSD 50 patients (39%), and MFD 7 patients (5%) was detected.

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PMC11786767

The nuclear nonhistone protein Ki-67 acts as a surfactant to form a repulsive molecular brush around fully condensed sister chromatids in early mitosis, preventing the diffusion or penetration of nuclear lipids into intrachromosomal regions.

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PMC11119602

When the TG2 protein sequence (accession n. P21980) was scanned for potential functional sites using the Eukaryotic Linear Motif (ELM) prediction server, several validated interaction sites and putative short linear motifs (SLiMs) based on the primary amino acid sequence of TG2-L were detected.

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PMC11697703

Immunolabeling for MAPK8 and GFP reveals an increase in the number of MAPK8+ neurons in cultures transfected with antisense miR-193b and antisense miR-365 compared to control cultures transfected with scrambled-miRNA (Figure 2F; Scram controls 17%, miR-193b-AS 46%, miR-365-AS 56%).

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PMC8345486

In contrast, an increase in expression of the p53 mutant (in OVCAR-3 and SKOV-3 cells) may be ineffective in triggering apoptotic processes due to the dysfunction of the mutant protein.

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PMC9895440

Specific lysis was calculated as above (killing assay).

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PMC11708541

All IN produced action potential bursts synchronized with the field potential trials that caused SLE termination as the condition progressed.

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PMC4112127

After shaking on a plate shaker for 3 hours at room temperature, fluorescence was measured at an excitation wavelength of 485 nm and emission wavelength of 520 nm on an FLx800 Microplate Fluorescence Reader (BIO-TEK Instruments Inc., Winooski, VT).

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PMC11806106

For the recording of dose-response curves the following protocol was used: first, the baseline-BRET was recorded.

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PMC10734950

This screen revealed a novel thiophene, F8 (methyl 5-[(dimethylamino)carbonyl]-4-methyl-2-[(3-phenyl-2-propynoyl) amino]-3-thiophenecarboxylate), that displays anti-cancer activity on lymphoma, leukemia, and other cancer cell lines.

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PMC3888431

Nevertheless, 17,883 homologs of mouse genes and 19,500 homologs of rat genes were identified by this approach.

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PMC10547921

Figure 20Design of carmaphycins analogs 114–122.Figure 20 Design of carmaphycins analogs 114–122.

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PMC8567602

The same approaches of co-IP and glycerol gradients of nuclear extracts were tested in mouse tumors, using combination genotype tumors with genetically silenced Smarcb1 as a negative control.

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PMC8956657

The MERS ORF4b NLS region peptide spans residues 19–39 and contains a FITC and Ahx linker (middle panel).

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PMC11788920

On the other hand, we observed dCas9 stall in only one of the three cases (RNP1 but not RNP6 or RNP7) when dCas9 targeted the TS.

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PMC11640555

Additionally, the caspase 3 level was increased only by the higher concentration of CX-4945, the 15 μM, 24 h after treatment (Figure 3I, densitometric analysis Figure 3(I1)), when compared to the 5 and 10 μM concentrations, which were not effective in activating apoptosis (Figure 3I, densitometric analysis Figure 3(I1)...

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PMC11787355

Some Figures were created with BioRender.com.

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PMC11127909

G The apoptosis rate is shown in bar charts, N = 3.

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PMC10723784

Representative data indicating the concentration response curves to CBD when cells were allowed to recover from exposure to CBD compared to when cells were in continuous contact with cannabinoids prior to the MTT assay over different contact times.

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PMC9503541

Centroid and profile data were selected for the MS1 and MS/MS data types, respectively.

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PMC9019892

Considering the well‐documented safety and pharmacokinetic profiles of nintedanib, this finding provides evidence for the repurposing of nintedanib as a new therapy for the treatment of GIST patients with de novo or acquired resistance to imatinib.fibroblast growth factors FGFR substrate 2 gastrointestinal stromal tumo...

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PMC9429973

In addition, ratios of 0% without indication of sensitivity were allocated as MR4 i.e. 0.01%.

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PMC11545737

The latter includes (i) programmed cell death, necessary for development or tissue turnover that does not rely on any exogenous stimuli and (ii) diverse forms of RCD that the cell activates depending on the stimuli received.

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PMC9545474

Her research activities focus on the design of polymers used as cargo to carry organometallic complexes for medical applications.

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PMC11535726

Asexual morph: Colonies on the natural substrate superficial, effuse, scattered, hairy, black, glistening.

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PMC9429973

More than one site extranodal involvement with lung or adrenal lesions increasing overall and early RR correspondingly.

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PMC10729469

After four trials (T1-T4) the mice were returned their cages for 30 min and reintroduced into the T4 arm for the delayed retention trial (T5).

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PMC4443654

The features associated with boundaries separating A and B compartments calculated from Hi-C eigenvectors have not been studied to our knowledge.

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PMC11704834

P<0.05 was considered to indicate a statistically significant difference.

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PMC2196094

The typical CTMC proteases RMCP-1, -5, -6, and CPA were found at very high frequencies in the serosal MC library, whereas a low number of, or a total lack of clones for the MMC proteases RMCP-2, -3, -4, and the members of the RMCP-8 family were detected in the same library.

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PMC11742231

Additionally, it addresses the issue of disregarding the significant interactions between atoms.

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PMC10748106

In Table 5 are listed some descriptors related to the reactivity, solubility, shape, and size of active iridoid glycosides and Geniposide.

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PMC11585565

Crude protein lysates were extracted by suspending the cell pellet in radio-immunoprecipitation assay (RIPA) buffer (50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1 mM EDTA, 0.1% (w/v) SDS, 0.25% (w/v) sodium deoxycholate, 1% (V/V) NP-40 and 1x protease inhibitor cocktail (Thermo Scientific)) on ice for 10 min before centrifugat...

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PMC10936243

Lack of physical resources (e.g. limited space in cat cage due to the small size of cage, insufficient bedding supplies) was one of the barriers experienced by participants (n = 14/20) to having proper practice management for cat patients.

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PMC11640419

Thus, when analyzing cell samples treated with compound 9a at concentrations of CC50 and 0.5CC50, a pronounced increase in caspases 9, 8, and JNK in the first 6 h of incubation is observed, which is a reliable indicator that the new hybrid molecule induces apoptosis in Jurkat cells via a p53-independent pathway.

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PMC10197932

In this general framework, Pappalettere et al. 10,6 tested the application of low-intensity US on U937 human myelomonocytic cells comparing the effects, in terms of rate of survival, when operating at fixed frequency rather than sweeping.

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PMC11487720

The damage causes further and rapid destruction in internal organs, and eventually leads to limb amputations, organ failure, and even death.

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PMC11767725

High-resolution, longitudinal studies integrating multi-omics datasets will be essential to elucidate host–microbiome dynamics.

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PMC9275501

Then, the extracted TE10 cell membrane and DSPE-PEG were self-assembled to wrap the drug-loaded PLGA NPs, so that the drug carrier had homologous targeting function, significantly improved the drug concentration of the target site.

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PMC11597167

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a common flavonoid derivative with marked biological activities .

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PMC10667689

Cell lines were stimulated with 50 ng of PMA (PeproTech, USA) final concentration, for 24 h. FITC anti-human CD366 [(TIM-3); clone: F38-2E2, isotype: Mouse IgG1, κ] (BioLegend, USA) was used to stain stimulated cells vs. control cells.

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PMC11641630

However, statistically significant differences were seen in intermediate-grade 5637 and low-grade SW780 cells when they were infected with mycobacteria (Figure 1B,C and Supplementary File).

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PMC11638764

Additionally, a key protein in the autophagy pathway, ATG5, showed downregulation in the CER compartment with a log2 fold change of -2.9 and significant upregulation in the INS compartment with a log2 fold change of 6.8 ( Fig. 1H ).

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PMC7452526

After incubation time, 20 μl of MTT (5 mg/mL) was added and the cells were incubated again for another 4 hrs at 37 °C in CO2 incubator.

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PMC5716223

Viability was evaluated by trypan blue exclusion assay performed at the same culture conditions.

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PMC9436459

Morusalbin C (49), the first non-ketalized MDAAs with an aromatic ring instead of cyclohexene ring, was recently identified from M. alba .

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PMC11201989

The speculated partner may probably be a motor protein that concentrates PD-L1 at the site, rather than a permanent component of the centrosome because the endogenous localization of PD-L1 is affected by the disruption of microtubules.

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PMC11604768

GPCRs were clustered using Euclidean distance with complete linkage.

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PMC11448304

Fig. 3Proteomic data on A549 and RA549.

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PMC11477621

The crude product was purified by silica gel chromatography to give the colorless oil 4i (829 mg, 77%).

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PMC9429973

All patients had bulky disease > 7cm, B symptoms and Stage ≥2.

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PMC10850553

The deposition of complement C3, C5 or C5b-9 complex in the kidney from the anti-Thy1.1-induced glomerulonephritis model of rats.

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PMC11627133

To validate the feasibility of this approach, we first determined the kinetic rate coefficients of the bifunctional AP3‐RhoBAST and SpyRho using stopped‐flow kinetic measurements.

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PMC11574271

F T24 cells were transfected with LV-miR-659-3p to create T24-659-3p cells, which were subsequently transfected with lentivirus overexpressing RON to generate T24-659-3p-RON cells.

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PMC11477621

Drawing inspiration from the structural resemblance between a natural product N-(3-carboxypropyl)-2-acetylpyrrole and phenylbutyric acid, a pioneer HDAC inhibitor evaluated in clinical trials, we embarked on the design and synthesis of a novel array of HDAC inhibitors containing an N-linked 2-acetylpyrrole cap by utili...

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PMC10170482

We revealed that the soft 3D CS microenvironment results in reducing mitochondrial function.

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PMC7433824

Detoxification of reactive oxygen species, cellular response to stress, glucose metabolism, and immunity‐related proteins were altered in P4‐treated GBM cell lines.

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PMC11422497

C-D) RT-qPCR analysis demonstrating the downregulation of miR-494-3p in GIST-T1 and GIST-882 cells lines and tissues, compared to HGSMC cells and adjacent tissues. (

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PMC9429973

However, reviewing the results of the alterations in the alpha genes in our laboratory, we have observed that triplications are not as infrequent as previously thought, either alone or associated with β-thalassemia.

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PMC10114490

White bar equals 75 μm.

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