OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8584319	This is because the concentration of refametinib used in this experimental condition was low and the treatment time was too short to observe an obvious cell death effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	Scale bars, 500 μm (G and K), 50 μm (H and L), 20 μm (H and L insets), 10 μm (J and N).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10994876	As illustrated in Fig. 3, the upregulation of YAP5SA leads to a significant downregulation in the expression of BAX (P-value < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11766350	Incorporating a TRAIL-targeting shRNA expression cassette within the backbone of the rAAV genome-encoding plasmid during triple-transfection of HEK293F cells reduced transgene expression and led to a 60% increase in the yield of rAAV-TRAIL compared to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	Significant difference was detected between α2β3γ2-GABAAR/NL2- and α2β3δ-GABAAR/NL2-expressing HEK293 cells (p = 0.003) or α2β3δγ2ICL- and α2β3δ-GABAAR/NL2-expressing HEK293 cells (p = 0.047).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11597291	For PEG polymers, complete decomposition was observed at 350–420 °C, regardless of the MW of the polymer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "PEG", "polymers", ...
PMC10523483	In addition, our recent ChIP-seq analysis of H1.2 in mouse inguinal white adipose tissue (GSE232530) revealed that H1.2 associates with over 10,000 genes under room temperature; following cold exposure, more than 1,000 genes exhibited altered binding affinity with H1.2, including genes involving in lipid metabolism, ox...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11715644	We adopt a biophysical approach combining microchannels and mutant epithelial cells to study monolayer migration into confinement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "adopt", "a", "biophysical", "approach", ...
PMC11541241	The hemibiotrophic fungus F. oxysporum is a soilborne pathogen and can infect a series of economically important crops including bananas, cotton, potatoes, and tomatoes (Dean et al., 2012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11609529	For cell cycle analysis, resuspended cells were fixed with 80% cold ethanol overnight, treated with 50 μg/mL RNase, and stained with PI solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11420784	Phosphatidylinositol 3-phosphate (PI3P) which is generated from phosphatidylinositol (PI) by phosphatidylinositol 3-kinase (PI3K), plays an essential role in preautophagosomal structure formation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Infectious complications were common (blood stream infections, 41% and invasive fungal infections, 28%) and 30-day mortality was 14%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10547921	The main challenge in the development of ADCs is related to dose-limiting toxicity (DLT), which indicates the difficulties to balance the efficacy of drug therapy with off-target toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, and ds were generated in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10578720	Acetylases reportedly use intermediate metabolites from the tricarboxylic acid (TCA) cycle as substrates for acetyl donors to carry out the acetylation of lysine residues in a target protein, while deacetylases are responsible for removing acetyl units from the lysine residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	The quantification of BAX and BCL-2 protein expression in the A2780 cell line incubated with different cobalt complexes in the A2780 cell line was determined by WB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11706776	C Effect of 40 mM KCl (high K) on CCE using Mn quenching assay and the normalized Mn quenching slope (N = 15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	At the end of the experiment, mice were sacrificed in accordance with standard protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "end", "of", "the", "experiment", ",", "m...
PMC11587606	The establishment of apicobasal polarity in epithelial cells is of critical importance in morphogenesis of mammary gland and other secretive gland tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "estab...
PMC11621493	DAG, diacylglycerol; LPC, lyso-phosphatidylcholine; LPE, lyso-phosphatidylethanolamine; MAG, monoacylglycerol; PLA2G4, phospholipase A2 group IV; TAG, triacylglycerol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11675244	Wnt signaling is also receptive to several other small molecule inhibitors that have already been approved for different pharmacological effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wnt", "signaling", "is", ...
PMC9429973	Summary/Conclusion: We have demonstrated the feasibility of combining epigenetic and genetic editing in HSPCs, to recapitulate disease-relevant hits using CRISPR/dCas9 to help us study the cellular processes that may underlie myeloid cancer development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Medium for all cell lines: RPMI 1640 supplemented with 10% FBS, 50 U/ml penicillin, and 50 µg/ml streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Medium", "fo...
PMC11473750	mRNA expression level of a RNF121, and, b a MYC gene signature in ganglia tissue and tumours from wild-type (WT) and TH-MYCN mice, obtained at different postnatal ages (1, 2, and 6 weeks of age; n = 4 per group).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median follow-up of these patients was 49 months (range: 2-156).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", "of", "these", "patients", "was", "49...
PMC11655536	Therefore, there could be other mechanisms contributing to HA-induced cell death in MM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "could", "be", "other", "mechanisms", ...
PMC11194678	Scale bars, 10 μm; insets, 2 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", ";", "insets", ",", "2", "μm", "." ] } ]
PMC11583010	A concentration range (1 pmol/L–6.67 nmol/L) of ETx-22 (from humanized 15A7.5 mAb, blue triangles) or an isotype control coupled to the same linker payload (open diamonds) was incubated with HCT-116-2G10 clone expressing human nectin-4 for 8 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6182045	Because of this, the antigenic potential of new vaccine immunogens may only be ultimately determined in human clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "of", "this", ...
PMC10212663	The risk distribution plot showed that as risk‐score increased, survival time decreased while death or recurrence rates increased (Figure 8(c)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Finally, in vivo CLDX model revealed limited effect of VEN and S64315 monotherapy, while the combination was able to effectively reduce the leukemic burden, resulting in increased overall survival (vehicle:15 vs Combo:42 days).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	Information regarding the genetic alteration features of PTBP1 in pan-cancer was obtained from Cbioportal platforms (https://www.cbioportal.org/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Information", "regarding", "the", "genetic",...
PMC11795610	In addition, Claudin-1 and E-adherin mRNA level was significantly upregulated during differentiation, which was compatible with the study of Sayedyahossein et al. These results suggested that myricetin promoted the keratinocytes differentiation induced by Ca.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11240052	Our CCK-8 experiment results showed under expression of hsa_circ_0008285 significantly inhibited the proliferation of ovarian cancer cells (Figure 2c, d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC11519788	Altogether, these results demonstrated that serine residue at position 514 within SBC motif of STAT3 protein was essential for its degradation mediated by SPOP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11612794	Asterisk indicates nonspecific bands. (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Asterisk", "indicates", "nonspecific", "bands", ".", "(" ] } ]
PMC11351758	High-glucose conditions induce metabolic substrate entry into the mitochondria, and this weakens the electron transport system, culminating in the overproduction of ROS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11748335	Although the enrichment scores of these large domains in common PMDs and common HMDs are not significantly different, they are more prominently enriched in S-PMDs, both at the peak level and domain level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699465	Data are represented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "represented", "as", "mean", "±", "SEM", "." ] } ]
PMC11285179	Consistently, the therapeutic efficacy of bevacizumab appeared to be positively correlated with RDH13 expression and negatively correlated with DHRS11 expression (Fig. 6G, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9398137	x axis displays days, where day 1 (D1) marks initiation of the therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "x", "axis", "displays", "days", ",", "where", "d...
PMC7185206	Primary melanoma samples were stained for ADAM10 (pink, column 1), ADAM17 (pink, column 2), and PD-L1 (brown, column 3) by immunohistochemistry (IHC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	The expressions of OPN, ANXA1, and ANXA2 induced by GOx injection were significantly lower in the kidneys of OSMRβ mice than in those of WT mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	The P value is reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "P", "value", "is", "reported", "." ] } ]
PMC9856122	Further, an in vitro study concludes that ZnO/BBR at various concentrations showed PL inhibition in the range of 70–98% and thus, suggested its role in SARS-CoV-2 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11093197	We assessed the phosphorylation profile of these two pathways in RB1‐depleted cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "assessed", "the", "phosphorylation", "profile", "of", "these", "two", "pat...
PMC11085211	This approach led to sixty-one different subfractions, of which nine, forming four different clusters, exhibited a significant biological activity in GIST cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10890307	In this study, we report how the specific growth rate, the specific consumption rates of glucose, lactate, and glutamine, and the specific rates of lactate and glutamate production were affected by changes in the microenvironment of lung tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964654	The wells were then inoculated with the addition of 100 μL of fungal suspensions and incubated for 24 h at 35 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11656657	B Weekly plasma samples were collected from each tumor-bearing mouse and control mice, to investigate circulating mMDSCs using FACS flow-cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Weekly", "pl...
PMC8345486	The synthesis of counterpart containing chromium 8-(5-azido-3-oxa- pentoxy)-3,3′-chroma bis(1,2-dicarba-closo-undekaborate](-1) (11) was performed analogously from 8-dioxane-[3,3′-chroma bis(1,2-dicarbollide)] (7) and is described herein (Scheme 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Mean total annual healthcare costs were $137,987 PPPY.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "total", "annual", "healthcare", "costs", "were", "$", "137,987", "PPPY", "." ] } ]
PMC9454178	Tumour volume was measured every three days by using the formula: V = 1/2* length (mm) * width (mm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11243198	Further, a computational molecular docking simulation predicted that BAS 07019774 binds to the ZF4 domain within the GLI1-DNA binding region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "a...
PMC11348300	We posit that owing to the ubiquitous presence of neovasculature in all tumor tissues, PRESTO holds the potential to accurately pinpoint the location of tumors in real time, with submillimeter accuracy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	I Then, all animals were further dissected to observe organ metastasis, and images of livers were illustrated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", "Then", ",", "all", "an...
PMC6892818	CD40 expression was detected using PE-conjugated mouse anti-human CD40 antibody and an isotype control IgG1-PE (BD Biosciences, Berks, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD40", ...
PMC11422150	GAPDH mRNA was amplified from the SCI samples, and GAPDH was used as an internal control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "mRNA", "was", "amplified", "from", ...
PMC11758416	Megan Levings, PhDDe Waal Malefyt et al., Boardman et al.Software and algorithmsFlowJoBD BiosciencesV10.10.0PrismGraphPadV10.3.1OtherBD Canto IIBD BiosciencesN/ABD FortessaBD BiosciencesN/ANalgene Rapid-Flow Sterile single use vacuum filter unitsThermo Fisher Scientific566-0020 Note: For CD8 T cell isolation, other com...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	For passaging, the cells were removed from the culture flask using a trypsin-EDTA solution (1:1) (PanEco, Russia), and washed with 10 mM PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10898159	For example, Mithramycin A inhibits the TF, SP1, which is also a major transcriptional activation of the KIT gene, thus explaining why Mithramycin A induces apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	EDTA (1 mM (was used as a positive control to inhibit IDE activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EDTA", "(", "1", "mM", "(", "was", "used", "as", ...
PMC9164404	A Differential lipids between PBS and Abplatin treated cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Differential", "lipids", "between", "PBS", "and", "Abplatin", "treated", "cells", "." ] } ]
PMC10582049	This can be explained by cellular plasticity of stromal cells, functional convergence, and similar microenvironmental influences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "can", "be", "explained", "by",...
PMC11575040	Overall survival (OS) was calculated as the date from the first pathological diagnosis of malignant melanoma to the date of all-cause mortality or that of the most recent follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	Scale bars: 500 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "500", "µm", "." ] } ]
PMC11599565	The expression of Notch1, E-cadherin and Vimentin was studied by Western blot, revealing that EMT takes place in SKOV3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", ...
PMC11026382	E.coli folA (the gene encoding DHFR) was cloned into the pHis8-3 expression vector using restriction sites NcoI and XhoI. DHFR was tagged in-frame with an N-terminal 8X-Histidine tag separated from the folA reading frame by a thrombin cleavage site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9430052	In addition, complete response (CR) rates of 40-54%, as reported in CD19-targeted CAR-T cell therapy for relapsed/refractory(r/r) large B-cell lymphoma, should be further improved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9503685	In particular, 20 mg/L CSA-131P caused a reduction of about 2 log at 2 h. Among AMPs, LL-37 was determined as the only AMP that caused a significant decrease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9847912	MOI, multiplicity of infection, expressed as the 50% tissue culture infectious dose (TCID50) per CEMss cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "MOI", ",", ...
PMC4695073	The relative mRNA levels were calculated as the value of 2 normalized to the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "mRNA", "levels", "were", "calculated", "...
PMC11656048	After 48 h, MG63 and 143B cells were treated with shikonin or vehicle control to evaluate the proliferation potential of the cell lines in presence and absence of shikonin, with 3 wells per group.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	RUNX1 was the most commonly mutated gene found in 22% (12/55), followed by ASXL1 mutated in 19% (10/55) and SRSF2 in 15%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	The phosphorylation of p65 was downregulated in BRD4-kockdown cells (Fig. 6a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "phosphorylation", "of", "p65", "was", "downregulated", "in", "BRD4-k...
PMC11806613	Scale bar, 1 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "1", "μm", "." ] } ]
PMC9429973	33 patients had ischemic stroke, 2 had hemorrhagic stroke and 10 had Moya-moya.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "33", "patients", "had", "ischemic", "stroke", ",", "2", "had", ...
PMC9429973	R. De La Camara, Z. Szmit, P. Ljungman, N. Knelange, L. Wendel, G. Tridello, K. Kalwak haematology, Hospital de la princesa, Madrid, Spain; Anesthesiology, Wroclaw Medical University, Wroclaw, Poland; Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institut...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8358006	The human ESCC cell lines KYSE450 and KYSE510 were provided by Dr. Yutaka Shimada (Kyoto University, Kyoto, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC9454178	GIST-T1 and GIST-882 cells were cultured at 37 °C with 5% CO2 in RPMI-1640 medium (Gibco, USA) supplemented with 10% foetal bovine serum and 1% penicillin–streptomycin (Gibco, USA).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9848491	Nominal P< 0.05 and FDR<0.25 were confirmed as statistical significance criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nominal", "P", "<", "0.05", "and", "FDR<0.25", "were", "confirmed", "as", ...
PMC11297139	Next, we examined the biological context in which endogenous ARID1A LLPS is observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "examined", "the", "biological", "context", "i...
PMC11714165	B–E) Quantification analysis of bone surface B), bone volume C), trabecular number D), and trabecular separation E) in tumor‐bearing mice tibias after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Is a true continuous heart rate collection necessary, or will a semi-continuous measurement suffice?	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Is", "a", "true", "continuous", "heart", "rate", "collectio...
PMC11754784	g Time and distance-dependent simulation of concentration changes of DNA strand caused by diffusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Time", "and", "distance-dependent", "simulation", "of", "concentr...
PMC11697703	Gene Ontology (GO) analysis of these predicted targets indicates that neuron development and neuron projection development are among the top ten over-represented biological processes for both miR-193b and miR-365 (Figures 1E and 1F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694625	MCF-7 cells were incubated for 48 h with varying concentrations 3b or 3c (3.5 μM, 7 μM and 10.5 μM), respectively.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC9429973	Over 10% of patients in both country groups (BA-HE- 14%; AA-HE-13%) reported getting a diagnosis more than 12 months after their first GP visit for their symptoms (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Figure 1 shows that there has been a significant decline in the number of RBC transfused from 2014 to 2021; an average gradient of -36.25 units per year (R= 0.72).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	To analyze the radial distribution of CTxB‐Alexa Fluor 555, the Broad Institute's Cell Profiler 3.0 software was used to generate a workflow. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11802929	CD8 T cells were captured by SCT-dextramers from 62 HLA-matched COVID-19 participants for scRNAseq and TCR sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD8", "T", "cells", "were", "captured", "by...
PMC7215722	By contrast, in DSS-treated cells, Endo H produced multiple protein bands of varying apparent molecular weights at around 85 kDa throughout the chase time points in addition to the 124 kDa mature Endo H-resistant band.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	The expression levels of hub genes in the TCGA-OV group were gathered and analyzed for differential expression between ovarian cancer (OV) and normal groups using the 'limma' package in R. The threshold was logfc>1 or logfc < −1, P < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Concerning the activated genes, TRAF2 is a remarkable example since TRAF family members (TRAF6, -4, -1) are found overexpressed in U-CLL and here we report an active region in subset #8 leading to TRAF2 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704834	Importantly, the TLE1/E-cadherin transcriptional axis is negatively regulated by gefitinib to trigger apoptosis via the Bcl-2-inhibitor of transcription 1 cell death pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importa...
PMC11612626	Serial imaging was performed at specified time points post-injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serial", "imaging", "was", "performed", "at", "specified", "time", "points", "post-injection", "." ] ...
PMC9429973	Data show sustained improvements in Hb, hemolysis, and ineffective erythropoiesis despite globin genotypic heterogeneity, and no new safety findings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "show...
PMC11271278	B The number of cancer cell lines that are identified to contain trans- and cis-enhancer hijacking events in our cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "number", "...
PMC9429973	E. Gargiulo, E. Viry, P. E. Morande, A. Largeot, S. Gonder, F. Xian, N. Ioannou, M. Benzarti, F. Kleine Borgmann, M. Mittelbronn, G. Dittmar, P. V. Nazarov, J. Meiser, B. Stamatopoulos, A. G. Ramsay, E. Moussay, J. Paggetti Luxembourg Institute of Health, Luxembourg, Luxembourg; Instituto de Medicina Experimental, Buen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	We used 8% native-PAGE to characterize the step-by-step assembly of DNA cage and used 5% native-PAGE to analyze the loading of functional module into DNA cage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8584319

This is because the concentration of refametinib used in this experimental condition was low and the treatment time was too short to observe an obvious cell death effect.

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PMC11697703

Scale bars, 500 μm (G and K), 50 μm (H and L), 20 μm (H and L insets), 10 μm (J and N).

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PMC10994876

As illustrated in Fig. 3, the upregulation of YAP5SA leads to a significant downregulation in the expression of BAX (P-value < 0.01).

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PMC11766350

Incorporating a TRAIL-targeting shRNA expression cassette within the backbone of the rAAV genome-encoding plasmid during triple-transfection of HEK293F cells reduced transgene expression and led to a 60% increase in the yield of rAAV-TRAIL compared to controls.

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PMC11295144

Significant difference was detected between α2β3γ2-GABAAR/NL2- and α2β3δ-GABAAR/NL2-expressing HEK293 cells (p = 0.003) or α2β3δγ2ICL- and α2β3δ-GABAAR/NL2-expressing HEK293 cells (p = 0.047).

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PMC11597291

For PEG polymers, complete decomposition was observed at 350–420 °C, regardless of the MW of the polymer .

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PMC10523483

In addition, our recent ChIP-seq analysis of H1.2 in mouse inguinal white adipose tissue (GSE232530) revealed that H1.2 associates with over 10,000 genes under room temperature; following cold exposure, more than 1,000 genes exhibited altered binding affinity with H1.2, including genes involving in lipid metabolism, ox...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11715644

We adopt a biophysical approach combining microchannels and mutant epithelial cells to study monolayer migration into confinement.

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PMC11541241

The hemibiotrophic fungus F. oxysporum is a soilborne pathogen and can infect a series of economically important crops including bananas, cotton, potatoes, and tomatoes (Dean et al., 2012).

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PMC11609529

For cell cycle analysis, resuspended cells were fixed with 80% cold ethanol overnight, treated with 50 μg/mL RNase, and stained with PI solution.

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PMC11420784

Phosphatidylinositol 3-phosphate (PI3P) which is generated from phosphatidylinositol (PI) by phosphatidylinositol 3-kinase (PI3K), plays an essential role in preautophagosomal structure formation .

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PMC9429973

Infectious complications were common (blood stream infections, 41% and invasive fungal infections, 28%) and 30-day mortality was 14%.

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PMC10547921

The main challenge in the development of ADCs is related to dose-limiting toxicity (DLT), which indicates the difficulties to balance the efficacy of drug therapy with off-target toxicity.

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PMC11634027

ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, ds, and ds were generated in this study.

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PMC10578720

Acetylases reportedly use intermediate metabolites from the tricarboxylic acid (TCA) cycle as substrates for acetyl donors to carry out the acetylation of lysine residues in a target protein, while deacetylases are responsible for removing acetyl units from the lysine residues.

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PMC10988555

The quantification of BAX and BCL-2 protein expression in the A2780 cell line incubated with different cobalt complexes in the A2780 cell line was determined by WB.

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PMC11706776

C Effect of 40 mM KCl (high K) on CCE using Mn quenching assay and the normalized Mn quenching slope (N = 15).

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PMC11701801

At the end of the experiment, mice were sacrificed in accordance with standard protocols.

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PMC11587606

The establishment of apicobasal polarity in epithelial cells is of critical importance in morphogenesis of mammary gland and other secretive gland tissues.

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PMC11621493

DAG, diacylglycerol; LPC, lyso-phosphatidylcholine; LPE, lyso-phosphatidylethanolamine; MAG, monoacylglycerol; PLA2G4, phospholipase A2 group IV; TAG, triacylglycerol.

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PMC11675244

Wnt signaling is also receptive to several other small molecule inhibitors that have already been approved for different pharmacological effects.

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PMC9429973

Summary/Conclusion: We have demonstrated the feasibility of combining epigenetic and genetic editing in HSPCs, to recapitulate disease-relevant hits using CRISPR/dCas9 to help us study the cellular processes that may underlie myeloid cancer development.

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PMC4270159

Medium for all cell lines: RPMI 1640 supplemented with 10% FBS, 50 U/ml penicillin, and 50 µg/ml streptomycin.

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PMC11473750

mRNA expression level of a RNF121, and, b a MYC gene signature in ganglia tissue and tumours from wild-type (WT) and TH-MYCN mice, obtained at different postnatal ages (1, 2, and 6 weeks of age; n = 4 per group).

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PMC9429973

Median follow-up of these patients was 49 months (range: 2-156).

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PMC11655536

Therefore, there could be other mechanisms contributing to HA-induced cell death in MM.

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PMC11194678

Scale bars, 10 μm; insets, 2 μm.

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PMC11583010

A concentration range (1 pmol/L–6.67 nmol/L) of ETx-22 (from humanized 15A7.5 mAb, blue triangles) or an isotype control coupled to the same linker payload (open diamonds) was incubated with HCT-116-2G10 clone expressing human nectin-4 for 8 days.

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PMC6182045

Because of this, the antigenic potential of new vaccine immunogens may only be ultimately determined in human clinical trials.

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PMC10212663

The risk distribution plot showed that as risk‐score increased, survival time decreased while death or recurrence rates increased (Figure 8(c)).

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PMC9429973

Finally, in vivo CLDX model revealed limited effect of VEN and S64315 monotherapy, while the combination was able to effectively reduce the leukemic burden, resulting in increased overall survival (vehicle:15 vs Combo:42 days).

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PMC11607764

Information regarding the genetic alteration features of PTBP1 in pan-cancer was obtained from Cbioportal platforms (https://www.cbioportal.org/).

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PMC11795610

In addition, Claudin-1 and E-adherin mRNA level was significantly upregulated during differentiation, which was compatible with the study of Sayedyahossein et al. These results suggested that myricetin promoted the keratinocytes differentiation induced by Ca.

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PMC11240052

Our CCK-8 experiment results showed under expression of hsa_circ_0008285 significantly inhibited the proliferation of ovarian cancer cells (Figure 2c, d).

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PMC11519788

Altogether, these results demonstrated that serine residue at position 514 within SBC motif of STAT3 protein was essential for its degradation mediated by SPOP.

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PMC11612794

Asterisk indicates nonspecific bands. (

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PMC11351758

High-glucose conditions induce metabolic substrate entry into the mitochondria, and this weakens the electron transport system, culminating in the overproduction of ROS.

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PMC11748335

Although the enrichment scores of these large domains in common PMDs and common HMDs are not significantly different, they are more prominently enriched in S-PMDs, both at the peak level and domain level.

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PMC11699465

Data are represented as mean ± SEM.

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PMC11285179

Consistently, the therapeutic efficacy of bevacizumab appeared to be positively correlated with RDH13 expression and negatively correlated with DHRS11 expression (Fig. 6G, H).

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PMC9398137

x axis displays days, where day 1 (D1) marks initiation of the therapy.

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PMC7185206

Primary melanoma samples were stained for ADAM10 (pink, column 1), ADAM17 (pink, column 2), and PD-L1 (brown, column 3) by immunohistochemistry (IHC).

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PMC7553912

The expressions of OPN, ANXA1, and ANXA2 induced by GOx injection were significantly lower in the kidneys of OSMRβ mice than in those of WT mice.

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PMC11721295

The P value is reported.

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PMC9856122

Further, an in vitro study concludes that ZnO/BBR at various concentrations showed PL inhibition in the range of 70–98% and thus, suggested its role in SARS-CoV-2 infection.

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PMC11093197

We assessed the phosphorylation profile of these two pathways in RB1‐depleted cells.

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PMC11085211

This approach led to sixty-one different subfractions, of which nine, forming four different clusters, exhibited a significant biological activity in GIST cells.

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PMC10890307

In this study, we report how the specific growth rate, the specific consumption rates of glucose, lactate, and glutamine, and the specific rates of lactate and glutamate production were affected by changes in the microenvironment of lung tumor cells.

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PMC9964654

The wells were then inoculated with the addition of 100 μL of fungal suspensions and incubated for 24 h at 35 °C.

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PMC11656657

B Weekly plasma samples were collected from each tumor-bearing mouse and control mice, to investigate circulating mMDSCs using FACS flow-cytometry.

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PMC8345486

The synthesis of counterpart containing chromium 8-(5-azido-3-oxa- pentoxy)-3,3′-chroma bis(1,2-dicarba-closo-undekaborate](-1) (11) was performed analogously from 8-dioxane-[3,3′-chroma bis(1,2-dicarbollide)] (7) and is described herein (Scheme 2).

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PMC9429973

Mean total annual healthcare costs were $137,987 PPPY.

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PMC9454178

Tumour volume was measured every three days by using the formula: V = 1/2* length (mm) * width (mm).

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PMC11243198

Further, a computational molecular docking simulation predicted that BAS 07019774 binds to the ZF4 domain within the GLI1-DNA binding region.

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PMC11348300

We posit that owing to the ubiquitous presence of neovasculature in all tumor tissues, PRESTO holds the potential to accurately pinpoint the location of tumors in real time, with submillimeter accuracy.

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PMC11574271

I Then, all animals were further dissected to observe organ metastasis, and images of livers were illustrated.

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PMC6892818

CD40 expression was detected using PE-conjugated mouse anti-human CD40 antibody and an isotype control IgG1-PE (BD Biosciences, Berks, UK).

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PMC11422150

GAPDH mRNA was amplified from the SCI samples, and GAPDH was used as an internal control.

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PMC11758416

Megan Levings, PhDDe Waal Malefyt et al., Boardman et al.Software and algorithmsFlowJoBD BiosciencesV10.10.0PrismGraphPadV10.3.1OtherBD Canto IIBD BiosciencesN/ABD FortessaBD BiosciencesN/ANalgene Rapid-Flow Sterile single use vacuum filter unitsThermo Fisher Scientific566-0020 Note: For CD8 T cell isolation, other com...

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PMC11726848

For passaging, the cells were removed from the culture flask using a trypsin-EDTA solution (1:1) (PanEco, Russia), and washed with 10 mM PBS.

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PMC10898159

For example, Mithramycin A inhibits the TF, SP1, which is also a major transcriptional activation of the KIT gene, thus explaining why Mithramycin A induces apoptosis .

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PMC9516401

EDTA (1 mM (was used as a positive control to inhibit IDE activity.

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PMC9164404

A Differential lipids between PBS and Abplatin treated cells.

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PMC10582049

This can be explained by cellular plasticity of stromal cells, functional convergence, and similar microenvironmental influences.

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PMC11575040

Overall survival (OS) was calculated as the date from the first pathological diagnosis of malignant melanoma to the date of all-cause mortality or that of the most recent follow-up.

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PMC11707577

Scale bars: 500 µm.

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PMC11599565

The expression of Notch1, E-cadherin and Vimentin was studied by Western blot, revealing that EMT takes place in SKOV3 cells.

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PMC11026382

E.coli folA (the gene encoding DHFR) was cloned into the pHis8-3 expression vector using restriction sites NcoI and XhoI. DHFR was tagged in-frame with an N-terminal 8X-Histidine tag separated from the folA reading frame by a thrombin cleavage site.

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PMC9430052

In addition, complete response (CR) rates of 40-54%, as reported in CD19-targeted CAR-T cell therapy for relapsed/refractory(r/r) large B-cell lymphoma, should be further improved.

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PMC9503685

In particular, 20 mg/L CSA-131P caused a reduction of about 2 log at 2 h. Among AMPs, LL-37 was determined as the only AMP that caused a significant decrease.

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PMC9847912

MOI, multiplicity of infection, expressed as the 50% tissue culture infectious dose (TCID50) per CEMss cell.

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PMC4695073

The relative mRNA levels were calculated as the value of 2 normalized to the control.

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PMC11656048

After 48 h, MG63 and 143B cells were treated with shikonin or vehicle control to evaluate the proliferation potential of the cell lines in presence and absence of shikonin, with 3 wells per group.

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PMC9429973

RUNX1 was the most commonly mutated gene found in 22% (12/55), followed by ASXL1 mutated in 19% (10/55) and SRSF2 in 15%.

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PMC6901583

The phosphorylation of p65 was downregulated in BRD4-kockdown cells (Fig. 6a).

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PMC11806613

Scale bar, 1 μm.

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PMC9429973

33 patients had ischemic stroke, 2 had hemorrhagic stroke and 10 had Moya-moya.

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PMC9429973

R. De La Camara, Z. Szmit, P. Ljungman, N. Knelange, L. Wendel, G. Tridello, K. Kalwak haematology, Hospital de la princesa, Madrid, Spain; Anesthesiology, Wroclaw Medical University, Wroclaw, Poland; Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Karolinska Institut...

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PMC8358006

The human ESCC cell lines KYSE450 and KYSE510 were provided by Dr. Yutaka Shimada (Kyoto University, Kyoto, Japan).

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PMC9454178

GIST-T1 and GIST-882 cells were cultured at 37 °C with 5% CO2 in RPMI-1640 medium (Gibco, USA) supplemented with 10% foetal bovine serum and 1% penicillin–streptomycin (Gibco, USA).

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PMC9848491

Nominal P< 0.05 and FDR<0.25 were confirmed as statistical significance criteria.

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PMC11297139

Next, we examined the biological context in which endogenous ARID1A LLPS is observed.

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PMC11714165

B–E) Quantification analysis of bone surface B), bone volume C), trabecular number D), and trabecular separation E) in tumor‐bearing mice tibias after treatment.

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PMC9429973

Is a true continuous heart rate collection necessary, or will a semi-continuous measurement suffice?

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PMC11754784

g Time and distance-dependent simulation of concentration changes of DNA strand caused by diffusion.

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PMC11697703

Gene Ontology (GO) analysis of these predicted targets indicates that neuron development and neuron projection development are among the top ten over-represented biological processes for both miR-193b and miR-365 (Figures 1E and 1F).

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PMC11694625

MCF-7 cells were incubated for 48 h with varying concentrations 3b or 3c (3.5 μM, 7 μM and 10.5 μM), respectively.

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PMC9429973

Over 10% of patients in both country groups (BA-HE- 14%; AA-HE-13%) reported getting a diagnosis more than 12 months after their first GP visit for their symptoms (Table 1).

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PMC9429973

Results: Figure 1 shows that there has been a significant decline in the number of RBC transfused from 2014 to 2021; an average gradient of -36.25 units per year (R= 0.72).

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PMC11615828

To analyze the radial distribution of CTxB‐Alexa Fluor 555, the Broad Institute's Cell Profiler 3.0 software was used to generate a workflow. ,

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PMC11802929

CD8 T cells were captured by SCT-dextramers from 62 HLA-matched COVID-19 participants for scRNAseq and TCR sequencing.

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PMC7215722

By contrast, in DSS-treated cells, Endo H produced multiple protein bands of varying apparent molecular weights at around 85 kDa throughout the chase time points in addition to the 124 kDa mature Endo H-resistant band.

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PMC11409031

The expression levels of hub genes in the TCGA-OV group were gathered and analyzed for differential expression between ovarian cancer (OV) and normal groups using the 'limma' package in R. The threshold was logfc>1 or logfc < −1, P < 0.05.

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PMC9429973

Concerning the activated genes, TRAF2 is a remarkable example since TRAF family members (TRAF6, -4, -1) are found overexpressed in U-CLL and here we report an active region in subset #8 leading to TRAF2 overexpression.

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PMC11704834

Importantly, the TLE1/E-cadherin transcriptional axis is negatively regulated by gefitinib to trigger apoptosis via the Bcl-2-inhibitor of transcription 1 cell death pathway.

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PMC11612626

Serial imaging was performed at specified time points post-injection.

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PMC9429973

Data show sustained improvements in Hb, hemolysis, and ineffective erythropoiesis despite globin genotypic heterogeneity, and no new safety findings.

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PMC11271278

B The number of cancer cell lines that are identified to contain trans- and cis-enhancer hijacking events in our cohort.

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PMC9429973

E. Gargiulo, E. Viry, P. E. Morande, A. Largeot, S. Gonder, F. Xian, N. Ioannou, M. Benzarti, F. Kleine Borgmann, M. Mittelbronn, G. Dittmar, P. V. Nazarov, J. Meiser, B. Stamatopoulos, A. G. Ramsay, E. Moussay, J. Paggetti Luxembourg Institute of Health, Luxembourg, Luxembourg; Instituto de Medicina Experimental, Buen...

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PMC11754784

We used 8% native-PAGE to characterize the step-by-step assembly of DNA cage and used 5% native-PAGE to analyze the loading of functional module into DNA cage.

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