OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11736898	Thus, inhibitors of CYP24A1 have been investigated for anticancer activities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "inhibitors", "of", "CYP24A1", "have", "been", "investigated", "for", "an...
PMC11673128	Cancer cells employ complex strategies to evade the immune system, allowing them to escape innate and adaptive surveillance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "employ", "comp...
PMC11763126	In our investigation, we detected 118 differentially expressed endogenous peptides in ccRCC utilizing peptidomics technology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "investigation", ",", "we", "detected", ...
PMC10565698	In addition, miR-211-5p expression negatively correlated with circUSP10 expression (Fig. 4I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "miR-211", "-", "5p", "exp...
PMC11683130	SerpinB2 is expressed in keratinocytes of the skin and one study suggested that SerpinB2 (cross-linked to the cornified envelope) was present in the stratum corneum (71).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	Reprinted with permission from . (	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reprinted", "with", "permission", "from", ".", "(" ] } ]
PMC9429973	HCPs also noted an unmet need for treatments that fully address end-organ damage in SCD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCPs", "also", "noted", "an", "unmet", "need", "for", ...
PMC9429973	Summary/Conclusion: This SLR has provided some insights into the global epidemiology of SCD, confirming earlier studies of areas with a high prevalence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8806312	Four genes, including CD79A, CSF3R, MTNR1B and NPPC, were used to establish a risk assessment model for evaluating OS prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	A. van der Velden, A. de Heij, C. Hazenberg, A. Reyners, P. de Graeff Expertise Center Palliative Care; Hematology, UMCG, Groningen, Netherlands Background: Disease trajectories and perspectives differ considerably between various subtypes of hematological malignancies, whereas determination of the transition point fro...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	D By contrast, staurosporine-induced apoptosis of L929S cells at 37 °C exhibited condensation and increased whole cell thickness reaching ~ 12 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11641532	The prepared cell suspension was then subcutaneously injected into the dorsal skin of 6-week-old female BALB/c nude mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "The", "prepared", "cell", "suspensi...
PMC11551844	It also increased the anticancer effects of anticancer agents on ovarian cancer cells and suppressed cell proliferation, cell cycle progression and cell aggregation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11680391	However, farmers differ in their opinions and behavior, and we therefore expected variation in the “Cooperation with the herd veterinarian” construct regarding the level of agreement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	edgeR accepts fractional counts directly, so the divided counts do not need to be rounded to integers (13,14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "edgeR", "accepts", ...
PMC9688728	Panoramic discovery-based metabolomic analysis generally aims to provide a comprehensive snapshot of the metabolome to illuminate certain compounds or features comprising the chemistry of the biological object under study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Cellular viability (%) in A2780 after 12 h of exposure to 20× IC50 concentrations of complexes 2 – 4 at 37 and 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Treatment-free remission was initiated by 16 (10%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment-free", "remission", "was", "initiated", "by", "16", "(", "10", "%", ")", ...
PMC9119314	Overall, this study aimed to explore the feasibility of utilizing the roots of C. sanguinolenta as a sustainable source of leads to novel antimalarial, antitrypanosomal, and anticancer drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	Similarly, in our adhesion cultures, OVACR-3 cells showed a similar response to platinum drugs as the A2780 cells, which were considered sensitive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC11185260	N = 4–5/group.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "N", "=", "4–5/group", "." ] } ]
PMC7987994	Numbers above the columns stand for the concentration of measured Zn in µM. The dashed line stands for the normative limit of 70% metabolic activity of the control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	Afterwards, 25 genes were taken to establish a prognostic risk model for categorizing OC patients into low-risk and high-risk group with discrete OS by LASSO Cox regression analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	This increase was also present in laser-capture microdissected C9orf72 patient spinal cord motor neurons, human iPS cell neurons treated with polyGR and Drosophila overexpressing polyGR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10891340	HSV-1 infection induces an upregulation of ROS (Kim et al., 2021), and here the same trend is observed in ROS after DPV infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Fifteen clinical trials, with a total of 7958 patients, have been included, while 16 different treatments were considered to build four different network meta-analyses to identify the best treatment in PFS, ORR, MRD, and tolerability: Acalabrutinib (ACA); ACA + Obinutuzumab (ACA-O); Alemtuzumab; Bendamustine +...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Y. Bouchakor Moussa, S. Taoussi, S. Oukid, F. Lamraoui, N. Rekab, K. M. Benlabiod, H. Brahimi, M. T. Abad, M. Bradai HEMATOLOGY, EHS ELCC CAC BLIDA Laboratory of Research on Malignant Hemopathies and Hemoglobinopathies, Faculty of Medicine, University Blida1, B.P 270, Route de Soumaa, Blida, Algeria; HEMATOLOGY, EHS EL...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462929	Quantitative RT‐PCR assay showed that MYC expression was significantly higher in BCP‐ALL cell lines with BENC‐CNA (n = 35) than in those without the amplification (n = 37; Figure 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	Fig. 7(a) The DLS peak (b) ThT fluorescence spectra at different concentrations, and (c) Turbidity assay graph of IA and IA + ZnO-NFs. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	T cell-derived hematological malignancies constitute a highly heterogeneous group of diseases with a poor prognosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cell-derived", "hematological", "malignancies", "constitute", ...
PMC11488203	Basically, primary miRs (pri-miRs) are formed after transcription from the DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Basically", ",", "primary", "miRs", "(", "pri-miRs", ")", "are",...
PMC2196094	In addition to MMCs, the small intestine probably contains a small fraction of CTMCs originating from the sub-mucosa and the muscular layer of this organ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11694066	As aberrant transcription factors not only cause replication stress but also enhance transcription, we next sought to assess R-loops.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "aberrant", "transcript...
PMC11381192	ANXA2 is reported to be significantly upregulated and correlate with inferior survival outcomes in MM, which is consistent with our findings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANXA2", "is"...
PMC8427838	Although, moesin and ezrin had been proposed to function as oncogenes in various tumor cell lines , their potential roles in RCC is not known.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11453018	Other drugs that have shown some effectiveness for ES, when used in combination with other treatments, include irinotecan, actinomycin D, regorafenib, clofarabine, cladribine, and trabectedin [40, 45–48].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588	Each occurrence of HF is associated with a significant disturbance of metabolic processes, insufficient energy supply in the myocardium, or abnormal redox processes that maintain the ROS balance under physiological conditions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Transfer the supernatant (unbound fraction) to a 1.5‐ml LoBind Eppendorf vial for checking and orthogonal purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfer", "the", "supernatant", "(", ...
PMC11666785	Actin198534542576Tubulin290790802830Mitochondria236784815891#MoleculesActin930761026197598177Tubulin25130337931932718Mitochondria112879755266774925 Estimation of critical biophysical parameters (mean localization precision, signal-to-background ratio, number of emitted photons per molecule and total number of molecules...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11423992	H_FCGR2B(CD32B) CHO-K1 cell line was purchased from Genomeditech Co., Ltd. (cat. #	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H_FCGR2B(CD32B", ")", "CHO-K1", "cell", "line", "was", ...
PMC11653533	In studies, it was found that the aqueous bark extract of F. racemosa showed larvicidal activity against fourth instar larvae of filariasis vector, Culex quinquefasciatus, and Japanese encephalitis vectors, Culex gelidus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10878518	In the malignant and intermediate group, tumors with high CAR expression exhibited significant increase in GFP expression between 24 and 48 h after OBP-401 infection (P = 0.034) (Fig 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	The RIACS with SIP can also be used to monitor and enrich metabolically active cancer cells that consume glucose at high rates and identify their genes and metabolic pathways responsible for the high activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	However, it remained unclear if and how APCs per se promoted changes to the effector function and motility patterns of CTLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11297139	Further examination using 3D confocal imaging revealed that these nuclear ARID1A foci detected in Ewing’s sarcoma patient and GFP-ARID1A knock-in A673 cell resembles spherical morphology (Supplementary Fig. 7a,b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC9429973	C. Jones, K. Chen, V. Narendran Internal Medicine, University of Miami / Palm Beach Regional GME Consortium, West Palm Beach; Hematology/Oncology, JFK Medical Center, Atlantis, United States of America Background: Thrombocytopenia is a common complication of COVID-19 (coronavirus disease 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2118063	The mammalian expression vector pSUPER.retro.puromycin (OligoEngine) was used for expression of siRNA in NFS-202 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "mammalian", "expression", "vector", ...
PMC9429973	Rate of CNS involvement due to relapse or disease progression was following – 4/51 (8%) of pts in the HD-MTX-group, 1/22 (5%) of pts – in the ETI-group, 5/17 (29%) of pts without any prophylaxis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11535726	Saprobic on an unidentified submerged decaying wood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Saprobic", "on", "an", "unidentified", "submerged", "decaying", "wood", "." ] } ]
PMC11597167	In order to determine the possible cytotoxic activity of the phenolic compounds determined to be the most active in terms of the anti-Alzheimer effect in human neuroblastoma cells, their cytotoxic effect on cell viability using SH-SY5Y human neuroblastoma cell line was evaluated using the Alamar Blue method, a fluorome...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	YK6-CD40lg-IL21 feeder cells were cultured as previously described .	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YK6-CD40lg-IL21", "feeder", "cells", "were", "cultured", "as", "previously", "described", "." ] } ]
PMC11772585	In our study, we observed a significant decrease in the mRNA levels of glycolytic metabolism-related genes following METTL1 knockdown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "study", "...
PMC10094992	Anti-mouse and anti-rabbit IgG peroxidase conjugated antibodies and reagents were from Sigma-Aldrich (St. Louis, MO, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-mouse", "and", "anti-ra...
PMC9429973	58.6% of the patients developed a new episode of neutropenic fever during induction chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "58.6", "%", "of", "the", "patients", "developed", "a", ...
PMC11047729	It was also used to prevent severe neutropenic enterocolitis in patients with AML, and cardiotoxicity in children with ALL, who are treated with doxorubicin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10840195	The figure only marks the significance of 96 h drug treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "figure", "only", "marks", "the", "significance", "of", "96", "h", "drug", ...
PMC3681794	Cells from the same pool were simultaneously seeded for quantification of Glut-1 and CA IX mRNA by qPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "from", "the", "same", "pool",...
PMC11597167	Isopropanol (500 µL) was added to the tube, and the mixture was incubated at room temperature for 10 min and centrifuged at 10,000 rpm for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11448304	Multi-omics combined analysis identified 19 significantly differentially expressed genes/proteins in total.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multi-omics", "combined", "analysis", "identified", "19", "significantly", "differentially", "exp...
PMC11767725	These effects were transient, normalizing by T28.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "effects", "were", "transient", ",", "normalizing", "by", "T28", "." ] } ]
PMC9920575	Chemotherapy is used in patients with cervical cancer to suppress DNA duplication or damage DNA in order to kill cancer cells that divide rapidly, but it is also used as an addition to definitive locoregional treatments (surgery or radiotherapy) to improve patient outcome and as a palliative therapy for patients with r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11186948	We performed whole exome sequencing (WES) for a patient (#249) clinically diagnosed with the chromatinopathy Rubinstein-Taybi syndrome (RSTS) but negative for mutations in RSTS genes, identifying a de novo frameshift variant in HDAC2 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8875242	Because the validity of accumulation studies in hPCIS strongly depends on hPCIS viability, we investigated the effect of 2.5 h treatments with [H]-digoxin (0.3 µCi/mL; 15 nM) together with antiretrovirals, DAAs, or CP100356 on the ATP content of hPCIS prepared from intestine samples collected from four donors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	We focused our additional studies on VAL cells in which 4EBP1 mRNA and protein were absent and cap dependent translation was resistant to asTORi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC10854447	Similarly, new isatin-1,2,4-oxadiazole hybrids were produced and tested for cytotoxicity against four human cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "new", "isatin-1,2,4-oxadiazole", ...
PMC11779605	Our analysis of serum FGF7 protein levels from patients with ovarian cancer found FGF7 protein expression above the median to be associated with worse progression-free survival and overall survival independent of patient and tumor characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743414	C Western Blot grayscale value quantification. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Western", "Blot", "grayscale", "value", "quantification", ".", "*" ] } ]
PMC5417661	The media were supplemented with 10% fetal bovine serum (FBS), glutamine (Sigma-Aldrich Corp.) and penicillin/streptomycin (Sigma-Aldrich Corp.), except for the MDA-MB-231-SA where 5% horse serum and for Caco-2 20% FBS were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	GET is a method used to introduce foreign genetic material (such as DNA or RNA) into cells by applying external pulsed electric fields (PEFs) to create temporary pores in the cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11789597	Since GSH is a key modulator of redox homeostasis, the oxidative‐ and antioxidant‐related indicators were examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "GSH", "is", "a", "key", "modulator...
PMC10482220	Induction of SG assembly was not due to the transfection itself because GFP alone (Fig. 4, panels 1–3) induced the formation of SGs to much lower levels (93% of the transfected cells for G3BP versus 28% for GFP, Fig. 2 A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10772747	This method allows researchers to understand the complex interactions between the compounds in EBE extract and the biological pathways involved in the growth and spread of breast cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745600	Ins1 NOG mice exhibited a reduction in the insulin content (Figure 3N) and plasma insulin concentration (Figure 3O), accompanied by a slight elevation in blood glucose levels (Figure 2A and B) despite their β-cell mass being comparable to that of wild-type mice (Figure 3M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	Its conversion rate is usually slow but can be significantly increased with the assistance of Guanosine triphosphatase-activating protein (GAP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "conversion", ...
PMC11539788	P < 0.05, P < 0.01, and *P < 0.001 We first explored the effect of ILK on the activation of the AKT/mTOR signalling pathway to determine whether the tumour-suppressive function of RNF19A in BCa cells relied on ILK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453018	Apoptosis was assessed using the APC Annexin V Apoptosis Detection Kit with 7-AAD (Biolegend, 640930), strictly following the manufacturer's guidelines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7185206	See Figure 1B.Cancer subtypeTCGA CodeHigh PD-L1 protein-to-mRNA ratio (n)Low PD-L1 protein-to-mRNA ratio (n)Hazard Ratio (survival)p valueProtein-to-mRNA ratio cutoffAdrenal cortical adenomaACC22704.959<0.00015.34E-06Urothelial Bladder CancerBLCA963361.4610.031031.77E-06Breast CancerBRCA54457.2430.004232.95E-06Cervical...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Significantly altered pathways in resistant cells, assessed by nascent proteomics, were largely reverted upon treatment of resistant cells with a PTK2B inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11727907	Investigating whether IGF-1 may affect the expression of PKM2 and its configuration into a dimer, our data show that treatment with IGF-1 significantly increased the expression of total PKM2 (Figure 1A) in ARPE-19 cells, inducing a time-dependent increase in the dimeric form (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	The results showed that FOXA2 which exerted its importance in the reprogram of glucose metabolism as an underlying protein interacting with HVEM (Supplementary file 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Since l-LV is one of the best transport substrates for both RFC and PCFT, a high expression of these transporters, both in tumor cells and normal cells, enables a fast and efficient uptake of l-LV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541409	This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10158546	Lentiviral-transduced ReN cell lines were produced that overexpress the mouse, hamster and human 129M and 129V versions of PrP. Lysate from proliferating ReN progenitor cell lines was western blotted for PrP using the 6H4 (recognizes mouse and human PrP) and 3F4 (recognizes hamster and human PrP) monoclonal antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10900886	Some EVs, for example, poliovirus and EV-A71 are known to replicate in lymphoid tissues, resulting in a sustained production of infectious viruses and subsequent spill-over into the circulation (26–30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Hazard ratios (HR) for OS show a trend toward favoring tafa + LEN in most patient subgroups (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hazard", "ra...
PMC11747467	In addition, MIBC cells have been classified into basal and luminal types (13), offering a foundation for subsequent preclinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11680049	Terpenoid compounds were also detected in significant quantities in the cells of the primary callus, and their staining intensity remained unchanged with successive passages (Figure 7g–i).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10719213	Cladribine has no effect on mtDNA mutagenesis in cultured lymphocytes of 12 donors (8 MS patients and 4 controls). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cladribine", ...
PMC11694066	PARPi and ATRi have synergistic cytotoxic effects in models of DSRCT with high PARP1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PARPi", "and", "ATRi", "have", "synergistic", "cytotoxic", ...
PMC9429973	Results: As of 29Jun2021, 90 of 103 adult pts in the registry had classifiable PKLR genotype data; 57 (63.3%) were classified as M/M, 28 (31.1%) as M/NM, and 5 (5.6%) as NM/NM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092382	However, further investigates of alternative cell types, such as cardiac myocytes or in vitro animal tissues, and comparisons of the findings with those obtained from HEK293 cells are needed to enhance the scientific rigor and broaden the scope of this research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: CCK-8 assay was used to analyze the proliferation of SUP-B15 cells treated with flumatinib only, ABT-199 only, combination group, and vehicle control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	Living cells were quantified at 24 h post-seeding (day 1) and at days 2, 3, and 4 using the CellTiter 96 Aqueous One Solution Cell Proliferation Assay (Promega).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	Our results showed that USP21 was detected on the promoters of IL-8 and USP21 knockdown significantly reduced the binding of USP21 to the promoter of IL-8 in 786-O cells (Figure 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Eighteen patients (60%; 18/30) had treatment after bortezomib regimens at a median of 5.3 months (0-75) and are alive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9412887	Acriflavine (ACF), a potent HIF-1 inhibitor, has been proven to bind to HIF-1α and thereby impede HIF-1α/β dimerization , which can be a useful strategy for sensitization of chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	By mechanistic studies, both Ag(I) and Au(I) selenourea complexes were found to selectively and strongly inhibit mammalian TrxR, being even much more effective than the reference metallodrug auranofin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Efficacy studies utilizing novel LMTK3 binding peptides (LMTK3BPs) showed that all chemosensitive and chemoresistant OC cells were killed without affecting normal cells (p < 0.005), with synergistic effects shown following cisplatin and docetaxel treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	It also had been used in combination with Atractylodes lancea (Thunb.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "had", "been", "used", "in", "combination", "with", "Atr...
PMC5941560	The number of single-nucleotide substitutions is similar to previously reported values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "single-nucleotide", "substitutions", "is", "similar", "to", "previou...

PMC11736898

Thus, inhibitors of CYP24A1 have been investigated for anticancer activities .

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PMC11673128

Cancer cells employ complex strategies to evade the immune system, allowing them to escape innate and adaptive surveillance.

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PMC11763126

In our investigation, we detected 118 differentially expressed endogenous peptides in ccRCC utilizing peptidomics technology.

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PMC10565698

In addition, miR-211-5p expression negatively correlated with circUSP10 expression (Fig. 4I).

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PMC11683130

SerpinB2 is expressed in keratinocytes of the skin and one study suggested that SerpinB2 (cross-linked to the cornified envelope) was present in the stratum corneum (71).

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PMC11806818

Reprinted with permission from . (

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reprinted", "with", "permission", "from", ".", "(" ] } ]

PMC9429973

HCPs also noted an unmet need for treatments that fully address end-organ damage in SCD.

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PMC9429973

Summary/Conclusion: This SLR has provided some insights into the global epidemiology of SCD, confirming earlier studies of areas with a high prevalence.

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PMC8806312

Four genes, including CD79A, CSF3R, MTNR1B and NPPC, were used to establish a risk assessment model for evaluating OS prognosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC9429973

A. van der Velden, A. de Heij, C. Hazenberg, A. Reyners, P. de Graeff Expertise Center Palliative Care; Hematology, UMCG, Groningen, Netherlands Background: Disease trajectories and perspectives differ considerably between various subtypes of hematological malignancies, whereas determination of the transition point fro...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11487720

D By contrast, staurosporine-induced apoptosis of L929S cells at 37 °C exhibited condensation and increased whole cell thickness reaching ~ 12 μm.

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PMC11641532

The prepared cell suspension was then subcutaneously injected into the dorsal skin of 6-week-old female BALB/c nude mice.

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PMC11551844

It also increased the anticancer effects of anticancer agents on ovarian cancer cells and suppressed cell proliferation, cell cycle progression and cell aggregation.

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PMC11680391

However, farmers differ in their opinions and behavior, and we therefore expected variation in the “Cooperation with the herd veterinarian” construct regarding the level of agreement.

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PMC11532793

edgeR accepts fractional counts directly, so the divided counts do not need to be rounded to integers (13,14).

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PMC9688728

Panoramic discovery-based metabolomic analysis generally aims to provide a comprehensive snapshot of the metabolome to illuminate certain compounds or features comprising the chemistry of the biological object under study.

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PMC10988555

Cellular viability (%) in A2780 after 12 h of exposure to 20× IC50 concentrations of complexes 2 – 4 at 37 and 4 °C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Treatment-free remission was initiated by 16 (10%) patients.

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PMC9119314

Overall, this study aimed to explore the feasibility of utilizing the roots of C. sanguinolenta as a sustainable source of leads to novel antimalarial, antitrypanosomal, and anticancer drugs.

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PMC8345486

Similarly, in our adhesion cultures, OVACR-3 cells showed a similar response to platinum drugs as the A2780 cells, which were considered sensitive.

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PMC11185260

N = 4–5/group.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "N", "=", "4–5/group", "." ] } ]

PMC7987994

Numbers above the columns stand for the concentration of measured Zn in µM. The dashed line stands for the normative limit of 70% metabolic activity of the control.

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PMC11531744

Afterwards, 25 genes were taken to establish a prognostic risk model for categorizing OC patients into low-risk and high-risk group with discrete OS by LASSO Cox regression analysis.

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PMC11001582

This increase was also present in laser-capture microdissected C9orf72 patient spinal cord motor neurons, human iPS cell neurons treated with polyGR and Drosophila overexpressing polyGR.

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PMC10891340

HSV-1 infection induces an upregulation of ROS (Kim et al., 2021), and here the same trend is observed in ROS after DPV infection.

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PMC9429973

Results: Fifteen clinical trials, with a total of 7958 patients, have been included, while 16 different treatments were considered to build four different network meta-analyses to identify the best treatment in PFS, ORR, MRD, and tolerability: Acalabrutinib (ACA); ACA + Obinutuzumab (ACA-O); Alemtuzumab; Bendamustine +...

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PMC9429973

Y. Bouchakor Moussa, S. Taoussi, S. Oukid, F. Lamraoui, N. Rekab, K. M. Benlabiod, H. Brahimi, M. T. Abad, M. Bradai HEMATOLOGY, EHS ELCC CAC BLIDA Laboratory of Research on Malignant Hemopathies and Hemoglobinopathies, Faculty of Medicine, University Blida1, B.P 270, Route de Soumaa, Blida, Algeria; HEMATOLOGY, EHS EL...

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PMC11462929

Quantitative RT‐PCR assay showed that MYC expression was significantly higher in BCP‐ALL cell lines with BENC‐CNA (n = 35) than in those without the amplification (n = 37; Figure 1C).

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PMC11684297

Fig. 7(a) The DLS peak (b) ThT fluorescence spectra at different concentrations, and (c) Turbidity assay graph of IA and IA + ZnO-NFs. (

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PMC11604015

T cell-derived hematological malignancies constitute a highly heterogeneous group of diseases with a poor prognosis .

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PMC11488203

Basically, primary miRs (pri-miRs) are formed after transcription from the DNA.

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PMC2196094

In addition to MMCs, the small intestine probably contains a small fraction of CTMCs originating from the sub-mucosa and the muscular layer of this organ.

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PMC11694066

As aberrant transcription factors not only cause replication stress but also enhance transcription, we next sought to assess R-loops.

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PMC11381192

ANXA2 is reported to be significantly upregulated and correlate with inferior survival outcomes in MM, which is consistent with our findings.

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PMC8427838

Although, moesin and ezrin had been proposed to function as oncogenes in various tumor cell lines , their potential roles in RCC is not known.

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PMC11453018

Other drugs that have shown some effectiveness for ES, when used in combination with other treatments, include irinotecan, actinomycin D, regorafenib, clofarabine, cladribine, and trabectedin [40, 45–48].

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PMC11594588

Each occurrence of HF is associated with a significant disturbance of metabolic processes, insufficient energy supply in the myocardium, or abnormal redox processes that maintain the ROS balance under physiological conditions .

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PMC6461034

Transfer the supernatant (unbound fraction) to a 1.5‐ml LoBind Eppendorf vial for checking and orthogonal purposes.

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PMC11666785

Actin198534542576Tubulin290790802830Mitochondria236784815891#MoleculesActin930761026197598177Tubulin25130337931932718Mitochondria112879755266774925 Estimation of critical biophysical parameters (mean localization precision, signal-to-background ratio, number of emitted photons per molecule and total number of molecules...

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PMC11423992

H_FCGR2B(CD32B) CHO-K1 cell line was purchased from Genomeditech Co., Ltd. (cat. #

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PMC11653533

In studies, it was found that the aqueous bark extract of F. racemosa showed larvicidal activity against fourth instar larvae of filariasis vector, Culex quinquefasciatus, and Japanese encephalitis vectors, Culex gelidus.

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PMC10878518

In the malignant and intermediate group, tumors with high CAR expression exhibited significant increase in GFP expression between 24 and 48 h after OBP-401 infection (P = 0.034) (Fig 5C).

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PMC7351993

The RIACS with SIP can also be used to monitor and enrich metabolically active cancer cells that consume glucose at high rates and identify their genes and metabolic pathways responsible for the high activity.

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PMC11718817

However, it remained unclear if and how APCs per se promoted changes to the effector function and motility patterns of CTLs.

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PMC11297139

Further examination using 3D confocal imaging revealed that these nuclear ARID1A foci detected in Ewing’s sarcoma patient and GFP-ARID1A knock-in A673 cell resembles spherical morphology (Supplementary Fig. 7a,b).

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PMC9429973

C. Jones, K. Chen, V. Narendran Internal Medicine, University of Miami / Palm Beach Regional GME Consortium, West Palm Beach; Hematology/Oncology, JFK Medical Center, Atlantis, United States of America Background: Thrombocytopenia is a common complication of COVID-19 (coronavirus disease 2019).

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PMC2118063

The mammalian expression vector pSUPER.retro.puromycin (OligoEngine) was used for expression of siRNA in NFS-202 cells.

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PMC9429973

Rate of CNS involvement due to relapse or disease progression was following – 4/51 (8%) of pts in the HD-MTX-group, 1/22 (5%) of pts – in the ETI-group, 5/17 (29%) of pts without any prophylaxis.

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PMC11535726

Saprobic on an unidentified submerged decaying wood.

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PMC11597167

In order to determine the possible cytotoxic activity of the phenolic compounds determined to be the most active in terms of the anti-Alzheimer effect in human neuroblastoma cells, their cytotoxic effect on cell viability using SH-SY5Y human neuroblastoma cell line was evaluated using the Alamar Blue method, a fluorome...

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PMC11045125

YK6-CD40lg-IL21 feeder cells were cultured as previously described .

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PMC11772585

In our study, we observed a significant decrease in the mRNA levels of glycolytic metabolism-related genes following METTL1 knockdown.

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PMC10094992

Anti-mouse and anti-rabbit IgG peroxidase conjugated antibodies and reagents were from Sigma-Aldrich (St. Louis, MO, USA).

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PMC9429973

58.6% of the patients developed a new episode of neutropenic fever during induction chemotherapy.

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PMC11047729

It was also used to prevent severe neutropenic enterocolitis in patients with AML, and cardiotoxicity in children with ALL, who are treated with doxorubicin .

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PMC10840195

The figure only marks the significance of 96 h drug treatment.

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PMC3681794

Cells from the same pool were simultaneously seeded for quantification of Glut-1 and CA IX mRNA by qPCR.

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PMC11597167

Isopropanol (500 µL) was added to the tube, and the mixture was incubated at room temperature for 10 min and centrifuged at 10,000 rpm for 10 min.

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PMC11448304

Multi-omics combined analysis identified 19 significantly differentially expressed genes/proteins in total.

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PMC11767725

These effects were transient, normalizing by T28.

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PMC9920575

Chemotherapy is used in patients with cervical cancer to suppress DNA duplication or damage DNA in order to kill cancer cells that divide rapidly, but it is also used as an addition to definitive locoregional treatments (surgery or radiotherapy) to improve patient outcome and as a palliative therapy for patients with r...

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PMC11186948

We performed whole exome sequencing (WES) for a patient (#249) clinically diagnosed with the chromatinopathy Rubinstein-Taybi syndrome (RSTS) but negative for mutations in RSTS genes, identifying a de novo frameshift variant in HDAC2 gene.

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PMC8875242

Because the validity of accumulation studies in hPCIS strongly depends on hPCIS viability, we investigated the effect of 2.5 h treatments with [H]-digoxin (0.3 µCi/mL; 15 nM) together with antiretrovirals, DAAs, or CP100356 on the ATP content of hPCIS prepared from intestine samples collected from four donors.

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PMC3931643

We focused our additional studies on VAL cells in which 4EBP1 mRNA and protein were absent and cap dependent translation was resistant to asTORi.

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PMC10854447

Similarly, new isatin-1,2,4-oxadiazole hybrids were produced and tested for cytotoxicity against four human cancer cell lines.

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PMC11779605

Our analysis of serum FGF7 protein levels from patients with ovarian cancer found FGF7 protein expression above the median to be associated with worse progression-free survival and overall survival independent of patient and tumor characteristics.

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PMC11743414

C Western Blot grayscale value quantification. *

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PMC5417661

The media were supplemented with 10% fetal bovine serum (FBS), glutamine (Sigma-Aldrich Corp.) and penicillin/streptomycin (Sigma-Aldrich Corp.), except for the MDA-MB-231-SA where 5% horse serum and for Caco-2 20% FBS were used.

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PMC11266100

GET is a method used to introduce foreign genetic material (such as DNA or RNA) into cells by applying external pulsed electric fields (PEFs) to create temporary pores in the cell membrane.

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PMC11789597

Since GSH is a key modulator of redox homeostasis, the oxidative‐ and antioxidant‐related indicators were examined.

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PMC10482220

Induction of SG assembly was not due to the transfection itself because GFP alone (Fig. 4, panels 1–3) induced the formation of SGs to much lower levels (93% of the transfected cells for G3BP versus 28% for GFP, Fig. 2 A).

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PMC10772747

This method allows researchers to understand the complex interactions between the compounds in EBE extract and the biological pathways involved in the growth and spread of breast cancer cells.

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PMC11745600

Ins1 NOG mice exhibited a reduction in the insulin content (Figure 3N) and plasma insulin concentration (Figure 3O), accompanied by a slight elevation in blood glucose levels (Figure 2A and B) despite their β-cell mass being comparable to that of wild-type mice (Figure 3M).

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PMC11257988

Its conversion rate is usually slow but can be significantly increased with the assistance of Guanosine triphosphatase-activating protein (GAP).

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PMC11539788

P < 0.05, **P < 0.01, and ***P < 0.001 We first explored the effect of ILK on the activation of the AKT/mTOR signalling pathway to determine whether the tumour-suppressive function of RNF19A in BCa cells relied on ILK.

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PMC11453018

Apoptosis was assessed using the APC Annexin V Apoptosis Detection Kit with 7-AAD (Biolegend, 640930), strictly following the manufacturer's guidelines.

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PMC7185206

See Figure 1B.Cancer subtypeTCGA CodeHigh PD-L1 protein-to-mRNA ratio (n)Low PD-L1 protein-to-mRNA ratio (n)Hazard Ratio (survival)p valueProtein-to-mRNA ratio cutoffAdrenal cortical adenomaACC22704.959<0.00015.34E-06Urothelial Bladder CancerBLCA963361.4610.031031.77E-06Breast CancerBRCA54457.2430.004232.95E-06Cervical...

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PMC9429973

Significantly altered pathways in resistant cells, assessed by nascent proteomics, were largely reverted upon treatment of resistant cells with a PTK2B inhibitor.

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PMC11727907

Investigating whether IGF-1 may affect the expression of PKM2 and its configuration into a dimer, our data show that treatment with IGF-1 significantly increased the expression of total PKM2 (Figure 1A) in ARPE-19 cells, inducing a time-dependent increase in the dimeric form (Figure 1B).

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PMC11794847

The results showed that FOXA2 which exerted its importance in the reprogram of glucose metabolism as an underlying protein interacting with HVEM (Supplementary file 4).

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PMC11371747

Since l-LV is one of the best transport substrates for both RFC and PCFT, a high expression of these transporters, both in tumor cells and normal cells, enables a fast and efficient uptake of l-LV.

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PMC11541409

This reference is of outstanding importance because it reports that ripretinib has the similar effcicay with sunitinib as a second line therapy drug for GIST patients after imatinib failure.

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PMC10158546

Lentiviral-transduced ReN cell lines were produced that overexpress the mouse, hamster and human 129M and 129V versions of PrP. Lysate from proliferating ReN progenitor cell lines was western blotted for PrP using the 6H4 (recognizes mouse and human PrP) and 3F4 (recognizes hamster and human PrP) monoclonal antibodies.

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PMC10900886

Some EVs, for example, poliovirus and EV-A71 are known to replicate in lymphoid tissues, resulting in a sustained production of infectious viruses and subsequent spill-over into the circulation (26–30).

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PMC9429973

Hazard ratios (HR) for OS show a trend toward favoring tafa + LEN in most patient subgroups (Table).

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PMC11747467

In addition, MIBC cells have been classified into basal and luminal types (13), offering a foundation for subsequent preclinical trials.

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PMC11680049

Terpenoid compounds were also detected in significant quantities in the cells of the primary callus, and their staining intensity remained unchanged with successive passages (Figure 7g–i).

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PMC10719213

Cladribine has no effect on mtDNA mutagenesis in cultured lymphocytes of 12 donors (8 MS patients and 4 controls). (

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PMC11694066

PARPi and ATRi have synergistic cytotoxic effects in models of DSRCT with high PARP1 expression.

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PMC9429973

Results: As of 29Jun2021, 90 of 103 adult pts in the registry had classifiable PKLR genotype data; 57 (63.3%) were classified as M/M, 28 (31.1%) as M/NM, and 5 (5.6%) as NM/NM.

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PMC11092382

However, further investigates of alternative cell types, such as cardiac myocytes or in vitro animal tissues, and comparisons of the findings with those obtained from HEK293 cells are needed to enhance the scientific rigor and broaden the scope of this research.

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PMC9429973

Methods: CCK-8 assay was used to analyze the proliferation of SUP-B15 cells treated with flumatinib only, ABT-199 only, combination group, and vehicle control.

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PMC10607604

Living cells were quantified at 24 h post-seeding (day 1) and at days 2, 3, and 4 using the CellTiter 96 Aqueous One Solution Cell Proliferation Assay (Promega).

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PMC5173112

Our results showed that USP21 was detected on the promoters of IL-8 and USP21 knockdown significantly reduced the binding of USP21 to the promoter of IL-8 in 786-O cells (Figure 7A).

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PMC9429973

Eighteen patients (60%; 18/30) had treatment after bortezomib regimens at a median of 5.3 months (0-75) and are alive.

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PMC9412887

Acriflavine (ACF), a potent HIF-1 inhibitor, has been proven to bind to HIF-1α and thereby impede HIF-1α/β dimerization , which can be a useful strategy for sensitization of chemotherapy.

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PMC10092581

By mechanistic studies, both Ag(I) and Au(I) selenourea complexes were found to selectively and strongly inhibit mammalian TrxR, being even much more effective than the reference metallodrug auranofin.

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PMC11406030

Efficacy studies utilizing novel LMTK3 binding peptides (LMTK3BPs) showed that all chemosensitive and chemoresistant OC cells were killed without affecting normal cells (p < 0.005), with synergistic effects shown following cisplatin and docetaxel treatment.

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PMC11075223

It also had been used in combination with Atractylodes lancea (Thunb.)

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PMC5941560

The number of single-nucleotide substitutions is similar to previously reported values.

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