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OTAR3088
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BioData-CellLine_annotated

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PMC11733919
Briefly, nonsenescent cells were treated with the drugs (0.1 to 10 μM) or the nanoplatforms (60 μg of Fe/mL) for 24 h (96-well plate, 10,000 cells per a well) and changes in the metabolic activity were investigated using the MTT assay.
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PMC9429973
CD7 CAR-T presents a potential therapeutic option for adults with R/R T cell malignancies, but the long-term prognosis remains to be observed and improved.
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PMC8382973
Overall, the data demonstrated that the rectal and vaginal microbiome is highly polymicrobial and remains largely stable during the course of HIV membrane fusion inhibitor 2P23 microbicide rectovaginal application.
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PMC11422150
P < 0.05 compared with the untreated SCI group.
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PMC8193813
All four sensors underwent pre- and post-sampling two- or three-point calibration using gases (Calgasdirect Inc., Huntington Beach, CA, USA) traceable to National Institute of Standards and Technology (NIST) standards.
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PMC11733919
Similar to normal cells, cancer cells were cultured for up to 7 days to allow the manifestation of a senescent phenotype.
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PMC9429973
Through this study we try to collect pharmacokinetic data on generic dasatinib in our population.
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PMC9429973
The first patient achieved TI on D+28 and the other achieved TI on D+39.
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PMC9822769
Energy-dependent transport is inhibited by the decrease in the ATP level that can be achieved by pretreatment with 2-deoxyglucose (2DG) and NaN3.
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PMC11243198
qRT-PCR was performed to quantify mRNA using TaqMan assay.
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PMC9429973
Pts will remain on study for 5 years after the last pt’s 1st treatment has been administered, unless they have discontinued early due to treatment failure, disease progression, intolerance, or investigator/pt decision.
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PMC11583690
Next, we used DTX at concentrations (in the solvent) of 0.25, 0.5, 0.75, 1.0, 1.25, and 1.5 mg/mL while keeping the nanoparticle mass constant (1 mg).
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PMC9325715
0.2 mL of bLTF suspension was transferred to a sample unit of Amicon Ultra Centrifugal Filtres cut-off 3 kDa.
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PMC11366496
Nevertheless, in glioma, neither the function nor the mechanism of RNF122 was clarified.
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PMC11772585
Data are shown as mean ± SEM.
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PMC11632064
BI-D1870 (#15264), BI 6727 (#18193), BIX 02565 (#19183), BRD7389 (#20214), Cdk2 inhibitor II (#15154), DCC-2036 (#21465), GSK2256098 (#22995), LJH685 (#19913), LJI308 (#19924), MRT68921 (#19905), PF-03814735 (#15015), SU11274 (#14861), and WHI-P154 (#16178) were purchased from Cayman Chemical.
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PMC11721295
This gives a multiplicity-adjusted P value for each comparison, which is reported.
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PMC11787355
5 ×10 TCR-T cells were resuspended in 4 µl PBS and stereotactically injected into the cerebral ventricle of the mice with the following coordinates: 0.5 mm left lateral to the bregma at the depth of 1.8 mm below the dural surface.
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PMC11698348
We therefore analysed DeltaNp63α, which is the predominant isoform expressed in the epidermis and we observed that overexpression of Elf5 in keratinocytes induced DeltaNp63α expression, while loss of Elf5 leads to a decrease in DeltaNp63α expression (S4 Fig).
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PMC7504302
In addition, the DepMap portal can also provide a top 10 preferentially essential genes list for each screened cell line.
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PMC11575040
Jiang et al. reported that lncRNA KCNQ1OT1 mediated the progression of cervical cancer by sponging miR-1270 as a ceRNA of LOXL2 through the PI3K/AKT pathway.
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PMC6034753
Although we examined the significance of this interacting region (130–140 aa) of Meq with a synthetic peptide, we could not demonstrate changes in the co-localization of the two proteins in the presence of the peptide in DF-1 cells.
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PMC3813807
Polyclonal TNFAIP1 (ProteinTech Group Inc., Chicago, IL, USA), monoclonal c-myc (Santa Cruz Biotechnology, Santa Cruz, CA, USA) and polyclonal β-actin (endogenous control; CWBIO, Beijing, China) antibodies, were incubated with the blot overnight at 4°C.
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PMC9429973
Aims: In this study, we aim to dissect the abnormal changes and functions of intrinsic γδ T cells in the context of AML and dig out the correlated factors in the AML tumor environment.
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PMC10761571
Monolayers of cancer cells (1✕10) were prepared and treated with the NPs.
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PMC9792775
Sarcomas are lethal tumors that do not respond well to chemotherapy, which remains a widespread and essential treatment for advanced malignant sarcomas (Martin-Broto et al., 2020; Oh et al., 2020).
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PMC9927933
Knockdown of CDH1, APC2 and SAG, but not of UBE2S and CDC20, increased DEPTOR protein levels with little or no effect on DEPTOR mRNA levels in both lung cancer cell lines (Figure 4A and Supplemental Figure 4A).
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PMC6160470
The complexity of P-gp binding sites could explain the observed ATPase activation by 1 µM concentration of DAC-2Amide and -3Amide.
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PMC11298021
Kong et al revealed that rapamycin arrests the cell cycle in T-ALL cells by lowering MYCN mRNA and protein expression in T-ALL patients and T-ALL cell line.
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PMC9504875
cDNAs of TRIM25 and its deletion mutants were also cloned into pEF4/Myc-His vector (Invitrogen).
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PMC10874773
They found that the inhibitory rates of compounds 3,4-dehydrooneomajucin and 1,2,3,4-tetradehydrooneomajucin on the Hepatitis B e antigen (HBeAg) and Hepatitis B surface antigen (HBsAg) expression were (30.08 ± 3.09)% and (11.43 ± 1.92)% at a concentration of 68.00 μmol/L, and (7.88 ± 1.21)% and (16.96 ± 4.24)% at a co...
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PMC5415764
The reaction mixture was maintained with mild stirring at 40 °C for 24 h. Similarly, PLGA-SS-PTX crude product was obtained by successively dialyzing against DMSO and deionized water using a dialysis tube (MWCO 1000) to remove by-products such as dicyclohexylurea and unreacted small molecules.
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PMC8735881
In brief, fusion genes sequentially encoding scFv or a bispecific inhibitor, a His tag, and the C-terminal 34-amino acid GPI-anchoring signal sequence of decay accelerating factor (DAF) were synthesized and then cloned into the hPGK-driven self-inactivating lentiviral transfer vector pRRLsin.
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PMC11745823
These regulatory bodies are tasked with supervising ethical considerations and safeguarding patients' rights and welfare during the study procedure.
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PMC11476222
All sphingolipids were selected as lipids of interest.
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PMC11720107
Due to different growth and climate conditions, in our study the two garlic cultivars from Poland (Harnaś, Ornak) and two garlic cultivars from Spain (Violeta and Morado) were selected for analysis.
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PMC11694346
In contrast, the BT-DNBS-treated cells showed a time-dependent increase in fluorescence intensity: weak fluorescence after 60 minutes (Fig. 8(b)), stronger fluorescence after 120 minutes (Fig. 8(c)), and even stronger fluorescence after 240 minutes (Fig. 8(d)).
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PMC10823017
Although c-Myc plays a central role in different types of cancer, it is still a challenge to consider c-Myc as a direct druggable target because there is difficulty in identifying the active site as well as challenges in designing membrane permeable small molecules (10).
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PMC9429973
The patient was not taking any medication.
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PMC11774747
Similar issues were observed in the other studies.
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PMC10568263
The BSA incubation time was optimized to be 30 min as it effectively blocked non-specific sites.
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PMC11306331
5Dissolution of the oncogenic fusion protein FUS-CHOP results in reversion transcriptional changes.
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PMC11678130
In particular, QUE has been described as a potential antimelanoma agent and is being investigated for the prophylaxis and treatment of CM, owing to its ability to suppress tyrosinase activity .
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PMC10878518
However, whether OBP-401 induces the cytopathic effect against tumor specimens following GFP induction remains unclear.
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PMC8193813
When combined with the source fuel supply rate and stack flow rates (to determine the dilution rate), measurements comparable to extractive stack sampling may be possible.
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PMC9739791
The complex was stable in the dark within 48 h, while about a third of the Pt(IV) prodrug 29 was reduced with an excessive amount of sodium ascorbate (50 equiv.),
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PMC11748335
Each column represents a Roadmap sample.
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PMC10114490
E mRNA level of CDKN1A and CDKN2A in iHDF-T at PD, PD and PD.
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PMC9429973
Early toxicity remains a concern in this population eventhough more manageable with Dara SC.
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PMC9019892
In addition, nintedanib was more effective than sunitinib in the GIST‐T1‐T670I and GIST‐5R cell lines, which are both imatinib resistant and harbour gatekeeper T670I and Δ560–578 KIT mutations.
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PMC10812665
Glu is metabolically related to His, as His can be metabolized to Glu via the intermediate urocanate.
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PMC11513571
Student’s paired t-test was performed to compare between both stimulants with B cells.
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PMC9611901
The manufacture and processing of leather has been based mainly on the use of chrome tanning salts for the last two centuries.
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PMC6803987
According to the instructions of the fluorescent quantitative polymerase chain reaction (FQ-PCR) kit, the series of standard samples were tested.
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PMC8164677
Figure 8Shows 2D interactions of the best pose of (A) bromodomain protein 1 (Brd1) with wedelolactone; (B) bromodomain protein 1 (Brd1) with olinone; (C) acetyl transferase tip60 (AT tip60) with wedelolactone, (D) acetyl transferase tip60 (AT tip60) with anacardic acid. (
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PMC11495567
The cells were then washed once with medium, and fresh experimental medium mixed with 0–1 μM concentrations of NSL-YHJ-2-27 or NSL-YHJ-2-46 were added to the wells.
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PMC11569208
We ordered oligos (Table S3) for insertion into the modified miR-30 cassette with the selected NTC and siACP2 sequence within the VSV∆51 backbone.
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PMC10748106
The 3D structures of the best designed iridoids based on the structure of Genipin, with their respective dipole vectors, are displayed in Figure S7.
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PMC11695546
The outcomes were tabulated as means ± SD); The MBC/MIC of the specimens ≤ 4 proposed their bactericidal impact towards H. pyloriTreatmentsInhibition area (mm)MIC (µg/mL)MBC (µg/mL)MIC/MBC IndexStandard drug*24.3 ± 0.631.25 ± 0.131.25 ± 0.11Crude oil23.0 ± 0.162.5 ± 0.1125.0 ± 0.22Ozonized oil28.2 ± 0.515.62 ± 0.231.25...
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PMC11487720
Finally, SDS-PAGE, electrotransferring to nitrocellulose membranes, and Western blotting were carried out.
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PMC11787651
About 200 ng of the sample was injected for each analysis.
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PMC9105697
Here, we present a methodologically sound approach for ctDNA monitoring in synovial sarcoma patients.
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PMC11612794
Right: Electrostatic potential of Mis12C mapped on the surface representation.
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PMC9812014
Tomatidine alkaloids also have anti-DENV activity.
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PMC9429973
Summary/Conclusion: Conclusion: Based on these results, we propose transient DUSP1/6 inhibition as a novel and unexpected concept for eliminating drug-resistant CLL cells.
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PMC11240052
Finally, we discovered that hsa_circ_0008285 was relatively overexpressed in ovarian cancer tissues.
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PMC9429973
Summary/Conclusion: Our survey shows that pregnancies in AYA ALL survivors are fairly uncommon but possible, even after allo-HSCT.
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PMC11380329
Afterwards, we treated the human ovarian cancer cells, OVCAR4, with different concentrations (1–400 μg/mL) of variable propolis types supplemented or not with vitamin D (0.0015–0.15 μg/mL) in order to evaluate the efficacy and the cytotoxic activities of our local P as compared to other types collected from different g...
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PMC10165258
Although high-throughput screening (HTS) of single-agent therapeutics has also been successfully implemented in 96- and 384-well formats, it is not always feasible to adapt such platforms to study drug combinations, even for a reduced subset of anti-cancer drugs.
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PMC11723947
In contrast to wild-type cells, which were poorly sensitive to the immunosuppressive activity of Treg in this setting, mutant cells almost completely repressed IFN-γ secretion and Granzyme B production (Fig. 7e, g).
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PMC11310713
The number of mammary gland epithelial cells positive for p53, PTEN, and KI67 were counted using ImageJ software.
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PMC5916734
The primers for RT-PCR were selected using the Beacon Designer v7.51 software; primer specificity was tested using the NCBI BLAST tool (http://www.ncbi.nlm.nih.gov/blast/Blast.cgi).
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PMC11544122
SNX9 represents an alternative endocytic adaptor for GPCR endocytosis.
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PMC7570809
HepG2 cells were cultured in 6 well plates until they reached the confluence, and were linearly scratched with a plastic pipette tip to create a wound .
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PMC9341513
Another possibility is that the experimental data lacks sufficient resolution to reveal these features.
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PMC10938377
NCP-conjugate structures were solved by molecular replacement (PHASER and MOLREP from the CCP4 package) using the 1.99 Å resolution crystal structure of native NCP, assembled with the same histones and 145 bp DNA fragment (pdb code 6IPU), as the reference model.
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PMC9429973
Risk of VTE was similar in CLL compared to MBL [HR (95% CI) = 0.90 (0.49-1.65)].
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PMC10874773
Fig. 7Acetal-hemiacetal and/or ortholactone.
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PMC10213179
We identified the ATOP EphA2 aptamer using a novel bioinformatics strategy that compared aptamers enriched during a protein SELEX using recombinant human EphA2 and a cell-internalization SELEX using EphA2-expressing MDA231 tumor cells.
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PMC9918897
The stock solution was divided into 400 × 1 mL Eppendorf tubes and stored frozen at −18 °C.
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PMC11802855
In the NC group, implantation of myeloma cells into the femurs also resulted in a decrease in BMD compared to normal mice.
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PMC11562028
The functional impairment of mitochondria and increased intracellular Ca concentration further led to the increase in the intracellular ROS levels and the inhibition of the PI3K/AKT signaling pathway.
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PMC9429973
Acute myeloid leukemia (AML) is a clonal malignant disease of hematopoietic stem and/or progenitor cells characterized by a block in myeloid differentiation and increased proliferation, which displays DDR defects.
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PMC10898159
However, a negative feedback loop causing KIT overexpression with an unknown mechanism offset the inhibitory role of miR-148b-3p.
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PMC8992508
MDR reversers, also defined chemosensitizers, are pump modulators that co-administered with antineoplastic agents, which are substrates of the transporters, could restore the efficacy of anticancer drugs in resistant cancer cells.
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PMC11790971
For each experiment, 2 mL of each cell culture content was extracted during passaging.
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PMC10297204
Therefore, we assumed that the anti-tumor effect was equivalent between these two ethanol concentrations.
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PMC11352666
Statistical analysis was performed using Prism 9 software, version 9.5.1 (GraphPad Software, San Diego, CA, USA).
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PMC9429973
These patients were still alive at the end of the observation period, but data about further treatment lines were missing.
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PMC11306019
It is calculated as ViaPP/BTZ - ViaBTZ, where Via represents cell viability (in %).
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PMC9429973
In pts who received 2CDA-based therapy, the ORR was 97%.
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PMC10114490
Next, we compared the toxicity of amiodarone (1–1000 µM), a well-characterized hepatotoxicant , in both diHLC-T by HCS using a multiparametric assay (Fig. 5F).
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PMC4270159
Scan film and quantify band intensity using densitometric analysis software.
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PMC9874064
For this specific reason, a series of USP1 inhibitor (USP1i, including C527 and ML-323, etc.)
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PMC11283030
GEO (Gene Expression Omnibus) dataset GSE36895 was used to validate the differential expression of ACLY.
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PMC11612626
Importantly, optimal endogenous T-cell and CAR T-cell efficacy is dependent on antigen density, and immunoproteasome activation increases the density of many antigens.
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PMC11360263
In previous studies, HCMV-IE1 was detected in long-term cultures of CTH, CTO, and CTP cells, confirming the sustained HCMV replication.
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PMC11621493
Keratinocyte differentiation was induced by increasing CaCl2 to 0.2 mM for 24 h. Before RNA isolation, primary and HaCaT keratinocytes were cultured in absence and the presence of IL17A and/or TNFα (20 ng/ml each) for 24 h. Ct values above 30 were considered as no or negligible expression for Pla2g4d (nd).
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PMC11742047
In this study, the effects of CBD on two types of leukeamia cancer cells were investigated, by focusing on the lipid changes induced by the treatment to understand the cellular response and the changes associated to disease progression.
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PMC9429973
Currently, we are performing in vivo biodistribution and efficacy studies using orthotopic mouse models.
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