PMCID string | Sentences string | ner list |
|---|---|---|
PMC10587429 | Flow cytometry antibody panel for evaluation of human engraftment in NSG-SGM3 mice. | [
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PMC11512230 | Our group has previously shown that AltMV SPV and AltMV SPVLP contain lysine and cysteine residues that are potentially accessible for conjugation . | [
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PMC11248911 | C NMR (DMSO-d6, δ ppm): 16.24, 31.69, 46.45, 63.11, 125.80, 127.18, 128.86, 143.87, 157.89, 176.49. | [
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PMC11423992 | To evaluate the activation of T cells by TFAB002s, co-cultures were established using WIL2-S cells and Jurkat cells that stably express the NFAT-luciferase reporter gene. | [
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PMC11449273 | Since there are no currently available cancer cell lines that endogenously express all three proteins (plakoglobin, p53-R273H and p53-R175H), we used the p53-null and plakoglobin-deficient H1299 non-small cell lung carcinoma cell line for our studies and exogenously expressed plakoglobin, p53-R273H and p53-R175H at res... | [
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PMC10728535 | There has been increasing interest in the use of integrated analysis for examining multiple independent microarray data sets. | [
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PMC11787381 | Fig. 5Effects of a formulation of bambuterol on locomotor activity and anxiety in mice in the open-field test. | [
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PMC9712534 | Experiments were repeated 3 times as described in (a). | [
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PMC10996034 | On the other hand, it has been shown that physical confinement during cancer cell migration triggers therapeutic resistance (50). | [
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PMC10222971 | These results are shown in dot plots, where the LL quadrant represents viable cells (both Annexin V and PI negative), the LR quadrant represents unviable cells (PI positive and Annexin V negative), the UL quadrant represents cells in early apoptosis/cell apoptosis (Annexin V positive and PI negative) and UR quadrant re... | [
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PMC8481254 | Moreover, YAP can promote the synthesis of HBP metabolites and cellular O-GlcNAcylation; therefore, YAP and O-GlcNAcylation can promote each other to establish a positive feedback loop. | [
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PMC11795610 | After Hoechst 33,258 staining, the nucleus of viable cells is normally blue, while the nucleus of apoptotic cells appears abnormally bright white color. | [
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PMC11640247 | While the activation of PAK1, MLK2, and N-WASP by RAC3-R66W likely plays an essential role in the pathophysiology of the severe prenatal manifestations, these effectors do not seem to influence SRF, NFκB, or AP1-mediated gene expression, which are essential for cell growth and proliferation. | [
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PMC6442998 | In GIST882 cells, activation of oncogenic KIT downstream pathways is modest (i.e. sensitive to imatinib). | [
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PMC11277157 | We identified STAT3 as a hub that connect stress, inflammation with transcription regulation (e.g., EGR1 and ATF3), and the DNA repair and cell cycle axis (CDKNA1 and DDB2). | [
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PMC6222726 | From this extract, Velazquez-Jimenez et al. isolated two aryltetraline lignans: (−)-deoxypodophyllotoxin (15) and (−)-morelensin (16) (Figure 3), and two dibenzylbutirolactone lignans: (−)-yatein (17) and (−)-5′-desmethoxy yatein (18) or bursehernin] (Figure 1) . | [
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PMC5034105 | The differential cell line susceptibility of our nonhuman cell lines to ZIKV may provide insights into the virus' potential animal reservoirs and alternative animal models. | [
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PMC9856122 | A few alkaloids such as columbamine iodide and jatorrhizine chloride also showed activity against HIV with IC50 values of 58 and 71 µg/mL respectively . | [
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PMC11643361 | These hard-to-reconcile results suggest that more focused or larger panels of cell lines, as well as expanded sets of activity assays, need to be systematically employed to accurately assess the biological activity of these metal complexes. | [
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PMC11782508 | Potentially therapeutic bacterial peptides offer several advantages. | [
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PMC11655536 | Cells were treated with HA at indicated concentration for 48 h. H The effect of HA on cell viability in ten primary MM patient cells. | [
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PMC9341513 | This means that we can make predictions about the 3D structure of cell types or tissues where Hi-C data is not available. | [
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PMC10788478 | p‐values <0.05 were considered statistically significant. | [
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PMC9784246 | Overall, scores of binding affinities of identified ligands suggest that the best binding ligands as inhibitors for HDAC6 mainly belong to epicatechin/catechin glycosides in which the glucosides moiety is essential for interactions. | [
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PMC11093197 | We discovered that pS62 and pT58 of c‐Myc were considerably decreased in RB1‐deficient cells (Figure 2B), while the mRNA level of c‐Myc was unaffected by RB1 loss (Figure S9). | [
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PMC11678130 | The data obtained from three individual tests for the experiments were statistically evaluated using the GraphPad Prism software, version 10.2.3 (GraphPad Software, San Diego, CA, USA, www.graphpad.com) and by employing two statistical methods: a one-way ANOVA and Dunnett’s multiple comparison test. | [
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PMC11547972 | The Bliss independence analysis verified synergistic interactions between amygdalin and SFN. | [
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PMC9429973 | Supported by MH CZ-DRO-VFN64165, DRO-UHKT00023736. | [
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PMC11568601 | The 143B and MG-63 cells were treated with different concentrations of TGT. | [
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PMC10170482 | Quantification of three independent experiments. (***) | [
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PMC9429973 | Any of three TKIs (imatinib, nilotinib, dasatinib) can be used in the first treatment line (I TL). | [
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PMC8010066 | Also, a slight decline of KPC expression level was observed in the PA-4 strain (P-value ≤ 0.001). | [
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PMC10588957 | The expression of AMPK and p-AMPK was detected by pre-incubating HepG2 cells for 1 h in the absence or presence of an AMPK inhibitor (Compound C). | [
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PMC11357960 | Association between the percentage change in UBE2I mRNA level and different white blood cell populations in peripheral blood of lung cancer patients. ( | [
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PMC11748363 | Tuberculosis (TB) is an old infectious disease for which eradication has not yet been successful. | [
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PMC11298021 | In Jurkat cells transfected with miR-3143 and treated with rapamycin, the mRNA expression of PI3K, AKT, mTOR, and S6KB1 genes was significantly decreased ( *** P<0.001, **** P<0.0001). ( | [
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PMC9926039 | While moderate morphine dose decreased TLR4 gene expression, it had a reverse effect in higher concentrations. | [
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PMC11747949 | The VEGF‐VEGFR axis is implicated in tumor neo‐angiogenesis and represents a prognostic marker in osteosarcoma patients (Zhang et al. 2021). | [
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PMC11670407 | The collected tumor tissues were embedded and sectioned for subsequent immunohistochemistry. | [
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PMC11106977 | This process may also be essential for osteoclast differentiation . | [
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PMC9220170 | It is known that seven mammalian selenoproteins are localized in the endoplasmic reticulum: SELENOM, SELENOT, SELENOF, SELENOK, SELENOS, SELENON, and DIO2. | [
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PMC11621493 | β-Actin served as loading control. | [
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PMC9429973 | Response rates will be analyzed with estimates and 95% confidence intervals based on exact binomial distribution. | [
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PMC10976516 | Seyed-Khorrami et al. used MSCs loaded with oncolytic reovirus in the syngeneic mouse TC-1 lung cancer model and tested their migratory potency in vivo after systemic infection and assessed the efficacy and quality of lung cancer treatment. | [
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PMC11732628 | The cDNA was amplified by qPCR using a SYBR green PCR Master Mix kit Takara, Toyobo, Japan). | [
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PMC9429973 | To date, it is unclear when these niche alterations occur and how they contribute to disease progression. | [
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PMC11607638 | Dulbecco's Modified Eagle's Medium (DMEM)/F12 medium (#C11330500BT) and fetal bovine serum (FBS) (#10099141) were bought from Thermo Scientific (Shanghai, China). | [
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PMC4443654 | Strong and significant correlations are seen between cell types for a variety of human higher-order domains, delineating variation in replication timing, lamin association and nuclear compartments derived from Hi-C eigenvectors . | [
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PMC7057940 | In addition, lysine-specific demethylase 3A has been reported to cause this silencing in tumorigenic ES scenarios (16). | [
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PMC9429973 | Secondary endpoints were the assessment of safety and tolerability of the treatment, the immunologic modifications induced by the procedure and the clinical response to treatment. | [
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PMC11574271 | We performed KEGG and GO analysis on these genes and combined the annotations in the GENE database to screen 13 genes that are directly related to cell migration and invasion (which include RON) (Fig. 2B). | [
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PMC11730311 | The plasma supernatant was stored at − 70 °C until analysis. | [
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PMC9622879 | The performance of our proposed CEMS is evaluated by applying to different communities with different number of homes. | [
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PMC11791478 | XB002, which was generated by conjugating 25A3 to the linker–payload, zovodotin (Fig. 2), had a DAR of ∼3.8 as determined from the calculation of peak areas from the reduced reverse-phase HPLC (Supplementary Fig. S3A). | [
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PMC9429973 | Significantly higher levels of NK cells: CD56dimCD16+ (median 8.93 vs 14.23%, p<0.01) and CD56brightCD16- (median 0.33 vs 0.52%, p=0.02) were found in men compared to women 3 months after withdrawal. | [
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PMC11306331 | FRB/FKBP dimerize in response to rapamycin. | [
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PMC8992508 | Some of the derivatives were also interesting MRP1 inhibitors, and some of them were efficacious in inhibiting BCRP. | [
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PMC9429973 | BcR IG reactivity profiling was performed for 6 LC-MBL cases, 10 HC-MBL cases and 9 CLL cases against 123 autoantigens using a protein microarray; validation tests were performed with ELISA. | [
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PMC11472639 | Data are mean ± SD, n = 8.Table 4Cells/μLPhenotypePre-exercisePost-exercise30-min post-exercise%Δ pre- to post-exerciseEffect of timePlasma cellsCD38CD1382.6 ± 5.65.4 ± 12.62.9 ± 6.258 ± 41F(1.00,7.00) = 1.25, p = 0.30, ηp = 0.15CD38CD138CD45CD19 (with light-chain restriction)2.1 ± 5.54.7 ± 12.32.3 ± 6.1121 ± 95F(1.00,... | [
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PMC9429973 | Among luspatercept pts, 13/153 (8.5%) progressed to HR-MDS/AML during the entire Tx period, compared with 5/76 (6.6%) placebo pts. | [
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PMC7987994 | Significance codes according to p value: 0 ‘***’0.001 ‘**’0.01 ‘*’0.05 (two-sample t-test). | [
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PMC11718031 | Fig. 3VCC and viability of cell cultures grown with different media-feed combinations VCC and viability of cell cultures grown with different media-feed combinations For IS CHO-G17.4 and IS CHO-G17.7, the cell viability of the fed-batch culture with all seven different feeds dropped down to below 80% after 8 days. | [
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PMC11543935 | Hydrogels were cultivated for 24 h before EP. | [
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PMC9812014 | two of them, flavesine-J and alopecurine-B alkaloids showed significant repressive activities by targeting the HBsAg and HBeAg secretions. | [
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PMC11700523 | MR transcriptional activity was investigated by luciferase assays, and protein levels were measured by Western blotting. | [
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PMC11462929 | A recent report demonstrated that EBNA2 upregulates MYC expression via the formation of a super‐enhancer at the regions 428 and 525 Kbp upstream of the transcription start site of MYC. | [
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PMC10887351 | S, Gα. | [
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PMC8357004 | Besides maximal apoptosis was seen in the combined treatment groups after 48 h of treatment (P < 0.001), Figure 5. | [
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PMC11345828 | NH4Cl, sat. | [
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PMC5716223 | The results showed that, under serum deprivation, the activity of CS and GAPDH, both involved in carbohydrates metabolism, was increased by NGF supplementation compared to control (CS: 21.7 and 55.2% increase for NGF 10 and 100 ng/ml respectively; GAPDH: 37.7 and 95.7% increase for NGF 10 and 100 ng/ml respectively (p ... | [
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PMC11363012 | The brown arrow indicates the group of cells that accumulates primarily flavonoids and secologanin (2). | [
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PMC10777969 | These results suggest that FCP23 acts in a manner similar to FCP6. | [
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PMC11745823 | The expression level is frequently elevated abnormally in several main or secondary malignant tumour tissues . | [
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PMC4695073 | Kaplan-Meier and log-rank tests were used to analyze patient survival time and curves. | [
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PMC8973725 | Figure 1.The online database showed that ZNF677 was considerably downregulated in tumor tissues. ( | [
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PMC7553912 | In addition, αSMA and Timp2 were increased on day 3 and day 6 compared with those on day 0 in WT mice (Fig. 3k,l). | [
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PMC11638288 | When M. tuberculosis infects mononuclear phagocytes, vimentin expressed on the surface of monocyte-macrophages binds to NKp46 on the surface of NK cells NKp46 and then causes NK cells to lyse macrophages engulfing Mycobacterium tuberculosis The molecular mechanism and function of NKp46 in combating M. tuberculosis infe... | [
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PMC11763764 | All reactions were performed with 5 biological replicates. | [
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PMC11388384 | Because SHH-Halo transitioned between diffusible populations very rapidly, we were forced to consider extremely short integration times (3 localization intervals, 18 ms) introducing error in the measurement of each population’s diffusion coefficient. | [
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PMC9429973 | Secondary and exploratory endpoints include the proportion of pts with a reduction in transfusions ≥33% and ≥50%, respectively, over 12 wks; reduction in transfusions over 12, 24 and 48 wks (Cohorts A/B); Hb response at Wks 24 and 48; and change from baseline in Hb over 12, 24 and 48 wks (Cohort C). | [
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PMC6642070 | This evidence promotes us to investigate whether statins affect lactate levels and their role in SAMS in mice. | [
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PMC9429973 | Moreover, they were characterized by reduced Ks (-22%, p<0.001) and prolonged CLT (+30%, p<0.001). | [
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PMC4360730 | This includes experimentally derived samples, heterogeneous cell populations derived from cultures and other biological components commonly used in experiments that do not have a singular anatomical term (15). | [
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PMC11078693 | Centrifuge the cells at 200 g and 4°C for 10 min.i. | [
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PMC11607321 | To ensure fair comparisons, conditionals were not incorporated into any of the selected methods during training. | [
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PMC11806106 | Sensor S266: same as M264, besides fragment 1 rev: CCCTTGCTCACCATCCGCGGCGATAGCATGCGAACGCTC; YFP fwd: TTCGCATGCTATCGCCGCGGATGGTGAGCAAGGGCGAG; YFP rev: TTTTCTTTGGAGCCGTTAACCTTGTACAGCTCGTCCATGCCG; fragment 2 fw: ACGAGCTGTACAAGGTTAACGGCTCCAAAGAAAAGGACAGGAATCT. | [
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PMC11740207 | Unlike LT-HSCs, ST-HSCs express surface markers such as CD34 and CD38 but not CD90, correlating with their rapid differentiation capacity (Wilson et al., 2007; Cabezas-Wallscheid et al., 2014; Zeng et al., 2022). | [
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PMC5925824 | Biacore T200 Evaluation Software (version 1.0) was used to analyze the results from the kinetic experiments. | [
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PMC11756514 | Subsequently, the bacteria were washed twice and incubated with 0.5 µg/mL streptavidin-BV421 (BD Bioscience). | [
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Subsequently",
",",
"the",
"bacteria",
"were",
... |
PMC11583010 | The Fc fragment includes amino acid substitutions (L234F, L235E, and P331S) to reduce FcγR binding (Fig. 3A). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
... |
PMC11670954 | . | [
{
"tags": [
"O"
],
"tokens": [
"."
]
}
] |
PMC11568601 | The in vivo validation confirmed that TGT stimulated osteosarcoma cell apoptosis through the ER stress-associated IRE1/CHOP pathway in vivo, accompanied by an increase in the expression of p-IRE1 and CHOP in tumor tissues. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11552389 | But FSIP1 expression is not statistically significant (Figure 1C). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"But",
"FSIP1",
"expression",
"is",
"not",
"statistically",
"significant",
"(",
"Figure",
... |
PMC11240448 | Thus, it is important to evaluate which data types cSTAR can use and how well it can cope with the sparseness and noisiness of biological and biomedical data. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9436459 | After acylation of S100 with thionyl chloride, the crude product benzoyl chloride S101 was directly conducted with S99 to form an acyloxy ketone, which was then converted into β-diketone S102 through a base-catalyzed Baker–Venkataraman rearrangement. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC10565698 | In parallel with the changes in cell phenotype, the expression of some proteins was altered. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"In",
"parallel",
"with",
"the",
"changes",
"in",
... |
PMC2193049 | Finally, reciprocal transplantation of the MAGE-3271–279 sequence into unrelated proteins indicated that the impaired generation of the antigenic peptide was not caused by residues flanking peptide MAGE-3271–279 (data not shown). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC4443654 | Acc., | [
{
"tags": [
"O",
"O",
"O"
],
"tokens": [
"Acc",
".",
","
]
}
] |
PMC11477621 | HRMS (ESI), m/z: calcd for C24H22ClN6O2: 461.1498 [M − H]; found: 461.1500. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"HRMS",
"(",
"ESI"... |
PMC11155445 | After performing titration three pKa values were found for three protonated sites LH, LH2, and LH3. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"After",
"performing",
"titration",
"three",
... |
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