OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11036064	Abel et al. have shown that the ectopic expression of KRas in murine glioneuronal precursor cells leads to intermediate and invasive glioma cells with 100 % penetrance (Abel et al., 2009).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	We used different concentrations of Sora and PFD in mouse normal liver cell line AML-12, and found that in normal liver cells, the combination of Sora and PFD had no synergistic effect, and cell proliferation was not significantly inhibited (Supplementary Fig.S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11040965	For surface staining, cells were incubated with mAb to surface antigens for 30 min at 4 °C and then washed twice in cold phosphate-buffered saline containing 0.1% bovine serum albumin before flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11222184	MCM2 is a vital regulator of DNA replication and silencing MCM2 triggered G1/S arrest in non-small cell lung carcinoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCM2", "is", "a", "vital", ...
PMC11748363	Yields are given in percent and refer to the amount of pure product after all purification steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yields", "are", "given", "in", "percent", "...
PMC11773391	Melanoma at early stages can be cured by the surgical resection of the primary lesion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "at", "early", "stages", "can", "be", "cured", ...
PMC9429973	A total of 4 (10%) pts experienced serious AEs, including 1 small intestinal obstruction, 1 pneumonia, 1 wound hemorrhage, and 1 case each of anemia and thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9096373	The RT equipment included a linear accelerator (Elekta, Stockholm, Sweden), with an energy of 6 MV X-ray, and a distance of l00 cm from the skin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3765139	Between 5 × 10 and 5 × 10 cells per tube were labeled with 5 μL of labeled monoclonal antibodies (mAbs) of interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7961460	Recently, a novel finding links HAS2 overexpression to altered ER signalling in ER positive MCF-7 cancer cell line .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ "Recently", ...
PMC9429973	S. Sartini, S. Fantini, S. Rontauroli, M. Mirabile, E. Bianchi, F. Badii, M. Maccaferri, P. Guglielmelli, T. Ottone, R. Palmieri, E. Genovese, C. Carretta, S. Parenti, S. Mallia, L. Tavernari, C. Salvadori, F. Gesullo, C. Maccari, M. Zizza, A. Grande, S. Salmoiraghi, B. Mora, L. Potenza, V. Rosti, F. Passamonti, A. Ram...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	A-B Effects of OST-01 on proliferation and apoptosis in primary HMEC and TNBC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "A-B", "Effects", "of", "OST-01", "on", "proliferation", "and"...
PMC9429973	Summary/Conclusion: Our results indicate that PTCy-haploPBSCT is a valid and safe strategy for preventing severe acute and chronic GVHD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "O...
PMC11354239	Cumulatively, these results demonstrated that in response to RTX-coated lymphoma cells, the NK cells are activated non-uniformly, in the matter of both cytokine production and degranulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Genotype analysis of the variant in unvaccinated cases is ongoing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genotype", "analysis", "of", "the", "variant", "in", "unvaccinated", "cases", "is", "ongoing", ...
PMC11286266	Analysis of total read counts and mapped reads to the CHO library analysed by MAGeCK [UTUS: untreated and unsorted; TS: treated (plus 2DG) and sorted; R1: round 1 of enrichment; R2: round 2 of enrichment; D: dull green fluorescent protein (GFP) population; B: bright GFP population; A–C: pools of cells]. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509224	The neurons’ mitochondrial activity decreased by 28.6 ± 3.4% (p < 0.001) after treatment with 200 µM H2O2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "neuro...
PMC9429973	Aims: To evaluate the efficacy of repeated infsion of MSCs in GVHD prophylaxis from D45 after haplo-HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "the", ...
PMC9398137	A, Cytotoxic effect S63845 (24-hour incubation) in S63845-resistant (S-R) DLBCL (TMD8, UPF4D) and BL (UPF9T) and corresponding controls (CTRL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-...
PMC11453018	Phalloidin (green) highlights cell morphology, and DAPI (blue) stains the nuclei.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phalloidin", "(", "green", ")", "highlights", "cell", ...
PMC11472569	Growing evidence shows the intercellular transfer of EVs between tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Growing", "evidence", "shows", "the", "intercellular", "transfer", "of", "EVs", "between", ...
PMC10831439	All experiments were performed with at least three different iNKT-cell donors, in duplicates or triplicates and repeated at least twice independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "exper...
PMC9429973	1 patient was readmitted on day 5 due to mucositis and oral intolerance and remained hospitalized until discharge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "patient", "was", "readmitted", "o...
PMC11655536	After adding with 400 μl of 1× Binding Buffer, the cell solution was analyzed by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "adding", "with", "400", ...
PMC11695623	Studies have shown that glycolysis is the preferred pathway of energy metabolism for cancer cells even when oxygen content is sufficient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", ...
PMC11521786	Considering that the HER3-specific PAbs generated by the candidate can also degrade these receptors (HER1 and HER2), it is likely that this mechanism further enhances apoptosis induction in cells treated with the generated PAbs from the HER3-based vaccine candidate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9599726	We demonstrate that a high level of TFRC is associated with high-risk GISTs, while a low level of TFRC is associated with very low risk, low-risk, and no-risk GIST samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718109	K Correlative light-electron microscopy (CLEM) of synaptophysin, VMAT2-GFP (green) and mCherry-synapsin (magenta) triple co-transfected COS7 cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC8409415	Detailed information is provided in Document S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detailed", "information", "is", "provided", "in", "Document", "S1", "." ] } ]
PMC11638255	Scale bar, 300 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "300", "µm", "." ] } ]
PMC11790971	In this study, we investigated the effectiveness of label-free multimodal nonlinear optical microscopy, combined with ML-assisted high-content analysis, for early identification of biopharmaceutical CHO cell lines with desired production phenotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC8041314	For compound categorization, the assembled data in Supplementary Table 1 has been fused to associate one compound with one single IC50 value (Supplementary Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10040136	Transwell assay results illustrated that human MSC could migrate towards GIST cells in vitro (Fig. 3A–C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transwell", "assay", "result...
PMC10506676	Following the manufacturer's instructions, isolated RNA (1000 ng/μL from each sample) was reverse transcribed into cDNA using an EasycDNA Synthesis Kit (AddScript RT-PCR SYBR Master, AddBio, Sweden).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11633763	Additionally, HK2 overexpression partially reversed the USP22 knockdown‐induced decrease in ECAR in 143B cells (Figure 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "HK2", ...
PMC11583690	An acetonitrile–water (60:40, v/v) mobile phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "acetonitrile", "–", "water", "(", "60:40", ",", "v/v", ")", "mobile", "ph...
PMC7553912	Data are expressed as mean ± SEM; n = 4–7 per group. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "mean", "±", "SEM", ";", ...
PMC10440586	Representative IHC staining images of CD99 and immune cell marker CD45.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "IHC", "staining", "images", "of", "CD99", "and", "immune", "cell", ...
PMC6182045	Overall, the MGAT1 CHO expressed rgp120 displayed better bNAb binding than CHO derived TZ9708 gp120 to three different families of bNAbs, indicating improved antigenic structure of neutralization sensitive epitopes to at least three different regions of the envelope protein.	[ { "tags": [ "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC10344560	A 37-year-old man presented with cloudy effluent, abdominal pain, and black debris appeared in the lumen of his PD catheter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "37-year...
PMC11507371	An immediate significant reduction was observed from 3.5 h of incubation, while adhesion was only affected later .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "immediate", "significant", "reduction"...
PMC10667689	Every experiment was performed in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "experiment", "was", "performed", "in", "triplicate", "." ] } ]
PMC10094992	TANs can be part of tumour-promoting inflammation or conversely, mediate antitumour responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TANs", "can", "be", "part", "of", "tumour-promoting", "inflammation", "or",...
PMC9599726	A model which emerged from our results demonstrated a link between the inhibition of the YAP pathway and ferroptosis in GIST cells after VP treatment (Figure 11B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674146	PIP3 then recruits the oncogenic signaling proteins like the serine and threonine kinase AKT (Vanhaesebroeck et al., 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PIP3", "then", "r...
PMC10154881	However, none of the tested mouse cancer cell lines expressed Nectin4, including E.G‐7 lymphoma and B16 melanoma (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O" ...
PMC11683130	In the skin of GPP patients, the expression and activity of IL-36α and IL-36γ is elevated in keratinocytes located around neutrophil microabscesses (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11700165	Hence, while these cell models are potentially valuable for dissecting molecular mechanisms; they may not fully recapitulate the cellular context in which these kinases naturally function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582828	The simple yet feasible theory we propose on the plausible laboratory origin of SARS-2 is reinforced by the highly statistically significant association between a lower prevalence of specific genetic blood markers in East and South Asian populations and lower mortality in comparison with Western Europeans during compar...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11365427	BM samples were centrifuged to separate BM supernatant and BM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", "samples", "were", "centrifuged", "to", "separate", "BM", "supernatant", "and", ...
PMC11659734	Through the monthly scientific meetings held at the Health Effects Laboratory she continuously increased her scientific knowledge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "the", "monthly", "scientific", "meetin...
PMC10253973	A metabolic disease such as diabetes type 2 is characterized by the decreased sensitivity of muscle tissues to fats and insulin, leading to poor blood sugar regulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10582049	Additionally, cells with a percentage of mitochondrial genes higher than 17% were excluded from the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "cells", "with", "...
PMC9727330	Finally, the flow cytometry assay (BD Accuri 6 Plus) was used to assess the protein levels using a resuspended pellet in 500 µl PBS (Abd El Maksoud et al., 2019b; Hamouda et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9031474	Natural drimanes and coloratanes, as well as their semi-synthetic derivatives, showed promising results against cancer cell lines with in vitro activities in the low micro- and nanomolar range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2193049	Where indicated, the proteasome inhibitor lactacystin (Biomol) was incubated for 15 min with proteasome at 25°C before the addition of the peptide substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Most patients begin their medical process through General Practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Most", "patients", "begin", "their", "medical", "process", "through", ...
PMC11659921	C, D) Analysis of TNFSF11 correlation with immune infiltration‐associated cells based on the xCELL method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "D", ")", "Analysis", "of", ...
PMC9352806	Surprisingly, worms treated with 100 and 200 μg/mL BMS exhibited anti-aging characterized by increased mean lifespan by 16.64% and 13.83% (Fig. 1H and Table 1, p < 0.001), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754784	The expression of CD80 was tested using flow cytometry to confirm the successful differentiation of M1 macrophages (Supplementary Fig. 37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expre...
PMC6892818	Bars show mean RLU of 3–4 technical replicates ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bars", "show", "mean", "RLU", "of", "3–4", "technical", "replicates", "±", "SEM", "." ...
PMC7039683	No further copy number analysis was carried out. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "further", "copy", "number", "analysis", "was", "carried", "out", ".", "(" ] } ]
PMC11592008	Moreover, cell swelling and membrane rupture can occur following the formation of GSDMD pores, resulting in pyroptotic cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11541409	Imatinib, a drug specifically designed to target the BCR-ABL oncoprotein in chronic myeloid leukemia, has also proven effective for primary GISTs (Fig. 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	Total protein extracts (50–100 mg/lane) were separated by SDS-PAGE under reducing conditions and blotted onto polyvinylidene fluoride membranes (Immobilon; Millipore, Billerica, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11714165	One‐factor analysis of variance (ANOVA) was used to examine differences between multiple groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One‐factor", "analysis", "of", "variance", "(", "ANOVA", ")...
PMC11472639	Participants attended a screening visit and underwent a 12-lead electrocardiogram (ECG) which was reviewed by a cardiologist to confirm eligibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Participants", ...
PMC11679033	Obtained results are reported in Table 1, while morphological features of dead cells are shown in Figure 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Obtained", "results", "are", "rep...
PMC11388384	Network diagrams were plotted in R using the library iGraph.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Network", "diagrams", "were", "plotted", "in", "R", "using", "the", "library", "iGraph", "...
PMC9429973	Only 42.3% had response to the treatment (25/76 complete responses and 11/76 partial responses).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "42.3", "%", "had", "response", "to"...
PMC11675244	However, the loss of APC function causes a constant activation of β-catenin, contributing to both the initiation and progression of colorectal cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11718031	Efficient and robust cell cultivation is required to ensure the desired and consistent quality of products.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efficient", "and", "robust", "cell", "cultivation", "i...
PMC11301242	Blue data points represent the same genes encoded on ecDNA in the A3KAW cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blue", "data", "points", "represent", "the", "same", ...
PMC11422497	Cell lysis was carried out using SDS lysis buffer (62.5 mM Tris-HCl, pH 6.8, 2% SDS, and 10% glycerol) at 95 °C for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794588	Borse et al. showed that lupeol has potent anti-proliferative and apoptotic effects in HeLa cells, reducing cell viability and migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Borse", "et", ...
PMC11786704	However, these synthetic substances often come with significant side effects and toxicity issues, such as hepatotoxicity and immunosuppression, thus limiting their widespread clinical application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	Each experiment was repeated three times with separate cell cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "repeated", "three", "times", "with", "separate", "cell", "cultures"...
PMC11767725	These findings highlight the intricate connections between metabolic disorders, the microbiome, and psoriasis, providing new opportunities for integrated treatment approaches that target both systemic and local factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11200978	In addition to the efficacy of CA alone, the use of adjuvants to increase the lethality of freezing has been well documented in many cancer types, including prostate , kidney , breast , lung , among others .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Our model for “high-risk of death” detection classified patients in the test dataset was with AUC 0.816 accuracy (95%CI 0.679-0.912, McNemar’s Test p-value = 0.5), with sensitivity 0.80 and specificity 0.82.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Humans have two isoforms of this enzyme (CTPS1 and CTPS2); human genetic studies have identified an essential and non-redundant role for CTPS1 in the proliferation of B and T cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	TSL-induced cell death in SK-BR-3 and ZR-75–1 cells was partially mitigated by EIPA (Figures 4A, B), and cytoplasmic vacuolization was almost entirely prevented when the cells were co-treated with EIPA (Figure 4C).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9646302	Thus, we hypothesized that LAPTM5 regulates ccRCC via MAPK pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "we", "hypothesized", "that", "LAPTM5", "regulates", "ccRCC", "via", "MAP...
PMC11397654	Once again, the 3-(trifluoromethyl)aniline derivative 31b did not show particularly high activity levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "again", ",", "the", "3-(trifluoromethyl)aniline", "derivative", ...
PMC11243198	< 500, LogP < 5, HBD < 5, HBA < 10) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "<", "500", ",", "LogP", "<", "5", ",", "HBD", "...
PMC9429973	Aims: To evaluate the safety, tolerability, and efficacy of magrolimab in combination with commonly used myeloma therapies in patients with relapsed/refractory MM (RRMM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	Annotation enrichment analysis of phosphoproteins up-regulated in either the PazR or A204 parental cells compared against the human genome using DAVID.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annotation", "enrichmen...
PMC10933092	Additionally, the mA modification in 5637 BLCA cells mainly occurs in the CAGGC motif, whereas Li et al. (Li et al., 2017) report a GUUCRA motif.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11412721	Equal numbers of cells of the indicated genotypes were seeded, then cultured for 15 hr with or without CCL21 and counted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "num...
PMC11082662	It is associated with highest mortality rate among all gynecological cancers, posing a serious threat to women’s lives (1,2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC10125312	Overall, under the same conditions, cancerous and noncancerous epithelial cell lines have different uptake capabilities, which is also seen between different tissues, compromising the efficacy of PPTT and highlighting the importance of studying more than one cell type to determine the uptake of nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4839679	The proportion of CE species in every sample was obtained by dividing the total ion intensity (sum of 106 scans) for each CE species by the total ion intensity obtained for all CE species assayed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9792775	We found that the expression of JAK2 was not changed but the p-JAK2, p-STAT3 was decreased significantly in the combination treatment (Figure 3), indicating the inactivation of JAK2/STAT3 pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745823	It has emerged as a biomarker and prospective target for diagnostic purposes, targeted therapy, as well as prognostic assessment of numerous diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The patient with DLBCL after CAR-T therapy had initial clinical response after two Glofitamab cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "with", "DLBCL", "after", "CAR-T", "therap...
PMC10317042	A promoter assay indicated that SOX10 knockdown lowered EWSR1 promoter activity (Fig. 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "promoter", "assay", "indicated", "that", "SOX10", "kno...
PMC9429973	Although the exact mechanism remains to be elucidated, reduced lymphocyte intratumoral infiltration coupled with the formation of neutrophil extracellular traps (or NETosis) have been postulated as endogenous mechanisms for tissue damage and inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732628	The proteins were extracted from the 143B cells using radioimmunoprecipitation (RIPA; Solarbio Technology Co., Ltd., Beijing, China) lysis buffer and the protein concentration was quantified using a bicinchoninic acid (BCA) protein assay kit (Thermo Fisher Scientific Inc.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730311	A peptide library was designed where all positions were systematically substituted into five different amino acids representing different physicochemical properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "peptide", "library", ...
PMC11656657	In contrast, HOS (Fig. 2A), RD, CT10 (Fig. 2B), RH4, RH41, RH30 (Fig. 2C), A-673 and SK-ES-1 (Fig. 2D), exhibited a significant proportion of GD2-negative cells.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", ...

PMC11036064

Abel et al. have shown that the ectopic expression of KRas in murine glioneuronal precursor cells leads to intermediate and invasive glioma cells with 100 % penetrance (Abel et al., 2009).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11772449

We used different concentrations of Sora and PFD in mouse normal liver cell line AML-12, and found that in normal liver cells, the combination of Sora and PFD had no synergistic effect, and cell proliferation was not significantly inhibited (Supplementary Fig.S4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11040965

For surface staining, cells were incubated with mAb to surface antigens for 30 min at 4 °C and then washed twice in cold phosphate-buffered saline containing 0.1% bovine serum albumin before flow cytometry.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11222184

MCM2 is a vital regulator of DNA replication and silencing MCM2 triggered G1/S arrest in non-small cell lung carcinoma .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MCM2", "is", "a", "vital", ...

PMC11748363

Yields are given in percent and refer to the amount of pure product after all purification steps.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yields", "are", "given", "in", "percent", "...

PMC11773391

Melanoma at early stages can be cured by the surgical resection of the primary lesion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "at", "early", "stages", "can", "be", "cured", ...

PMC9429973

A total of 4 (10%) pts experienced serious AEs, including 1 small intestinal obstruction, 1 pneumonia, 1 wound hemorrhage, and 1 case each of anemia and thrombocytopenia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9096373

The RT equipment included a linear accelerator (Elekta, Stockholm, Sweden), with an energy of 6 MV X-ray, and a distance of l00 cm from the skin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3765139

Between 5 × 10 and 5 × 10 cells per tube were labeled with 5 μL of labeled monoclonal antibodies (mAbs) of interest.

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PMC7961460

Recently, a novel finding links HAS2 overexpression to altered ER signalling in ER positive MCF-7 cancer cell line .

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PMC9429973

S. Sartini, S. Fantini, S. Rontauroli, M. Mirabile, E. Bianchi, F. Badii, M. Maccaferri, P. Guglielmelli, T. Ottone, R. Palmieri, E. Genovese, C. Carretta, S. Parenti, S. Mallia, L. Tavernari, C. Salvadori, F. Gesullo, C. Maccari, M. Zizza, A. Grande, S. Salmoiraghi, B. Mora, L. Potenza, V. Rosti, F. Passamonti, A. Ram...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806613

A-B Effects of OST-01 on proliferation and apoptosis in primary HMEC and TNBC cells.

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PMC9429973

Summary/Conclusion: Our results indicate that PTCy-haploPBSCT is a valid and safe strategy for preventing severe acute and chronic GVHD.

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PMC11354239

Cumulatively, these results demonstrated that in response to RTX-coated lymphoma cells, the NK cells are activated non-uniformly, in the matter of both cytokine production and degranulation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Genotype analysis of the variant in unvaccinated cases is ongoing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genotype", "analysis", "of", "the", "variant", "in", "unvaccinated", "cases", "is", "ongoing", ...

PMC11286266

Analysis of total read counts and mapped reads to the CHO library analysed by MAGeCK [UTUS: untreated and unsorted; TS: treated (plus 2DG) and sorted; R1: round 1 of enrichment; R2: round 2 of enrichment; D: dull green fluorescent protein (GFP) population; B: bright GFP population; A–C: pools of cells]. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11509224

The neurons’ mitochondrial activity decreased by 28.6 ± 3.4% (p < 0.001) after treatment with 200 µM H2O2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "neuro...

PMC9429973

Aims: To evaluate the efficacy of repeated infsion of MSCs in GVHD prophylaxis from D45 after haplo-HSCT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "evaluate", "the", ...

PMC9398137

A, Cytotoxic effect S63845 (24-hour incubation) in S63845-resistant (S-R) DLBCL (TMD8, UPF4D) and BL (UPF9T) and corresponding controls (CTRL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "I-...

PMC11453018

Phalloidin (green) highlights cell morphology, and DAPI (blue) stains the nuclei.

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PMC11472569

Growing evidence shows the intercellular transfer of EVs between tumor cells.

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PMC10831439

All experiments were performed with at least three different iNKT-cell donors, in duplicates or triplicates and repeated at least twice independently.

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PMC9429973

1 patient was readmitted on day 5 due to mucositis and oral intolerance and remained hospitalized until discharge.

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PMC11655536

After adding with 400 μl of 1× Binding Buffer, the cell solution was analyzed by flow cytometry.

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PMC11695623

Studies have shown that glycolysis is the preferred pathway of energy metabolism for cancer cells even when oxygen content is sufficient.

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PMC11521786

Considering that the HER3-specific PAbs generated by the candidate can also degrade these receptors (HER1 and HER2), it is likely that this mechanism further enhances apoptosis induction in cells treated with the generated PAbs from the HER3-based vaccine candidate.

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PMC9599726

We demonstrate that a high level of TFRC is associated with high-risk GISTs, while a low level of TFRC is associated with very low risk, low-risk, and no-risk GIST samples.

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PMC11718109

K Correlative light-electron microscopy (CLEM) of synaptophysin, VMAT2-GFP (green) and mCherry-synapsin (magenta) triple co-transfected COS7 cell.

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PMC8409415

Detailed information is provided in Document S1.

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PMC11638255

Scale bar, 300 µm.

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PMC11790971

In this study, we investigated the effectiveness of label-free multimodal nonlinear optical microscopy, combined with ML-assisted high-content analysis, for early identification of biopharmaceutical CHO cell lines with desired production phenotypes.

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PMC8041314

For compound categorization, the assembled data in Supplementary Table 1 has been fused to associate one compound with one single IC50 value (Supplementary Table 2).

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PMC10040136

Transwell assay results illustrated that human MSC could migrate towards GIST cells in vitro (Fig. 3A–C).

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PMC10506676

Following the manufacturer's instructions, isolated RNA (1000 ng/μL from each sample) was reverse transcribed into cDNA using an EasycDNA Synthesis Kit (AddScript RT-PCR SYBR Master, AddBio, Sweden).

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PMC11633763

Additionally, HK2 overexpression partially reversed the USP22 knockdown‐induced decrease in ECAR in 143B cells (Figure 5E).

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PMC11583690

An acetonitrile–water (60:40, v/v) mobile phase.

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PMC7553912

Data are expressed as mean ± SEM; n = 4–7 per group. *

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PMC10440586

Representative IHC staining images of CD99 and immune cell marker CD45.

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PMC6182045

Overall, the MGAT1 CHO expressed rgp120 displayed better bNAb binding than CHO derived TZ9708 gp120 to three different families of bNAbs, indicating improved antigenic structure of neutralization sensitive epitopes to at least three different regions of the envelope protein.

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PMC10344560

A 37-year-old man presented with cloudy effluent, abdominal pain, and black debris appeared in the lumen of his PD catheter.

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PMC11507371

An immediate significant reduction was observed from 3.5 h of incubation, while adhesion was only affected later .

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PMC10667689

Every experiment was performed in triplicate.

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PMC10094992

TANs can be part of tumour-promoting inflammation or conversely, mediate antitumour responses .

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PMC9599726

A model which emerged from our results demonstrated a link between the inhibition of the YAP pathway and ferroptosis in GIST cells after VP treatment (Figure 11B).

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PMC11674146

PIP3 then recruits the oncogenic signaling proteins like the serine and threonine kinase AKT (Vanhaesebroeck et al., 2010).

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PMC10154881

However, none of the tested mouse cancer cell lines expressed Nectin4, including E.G‐7 lymphoma and B16 melanoma (Figure 1A).

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PMC11683130

In the skin of GPP patients, the expression and activity of IL-36α and IL-36γ is elevated in keratinocytes located around neutrophil microabscesses (30).

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PMC11700165

Hence, while these cell models are potentially valuable for dissecting molecular mechanisms; they may not fully recapitulate the cellular context in which these kinases naturally function.

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PMC10582828

The simple yet feasible theory we propose on the plausible laboratory origin of SARS-2 is reinforced by the highly statistically significant association between a lower prevalence of specific genetic blood markers in East and South Asian populations and lower mortality in comparison with Western Europeans during compar...

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PMC11365427

BM samples were centrifuged to separate BM supernatant and BM cells.

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PMC11659734

Through the monthly scientific meetings held at the Health Effects Laboratory she continuously increased her scientific knowledge.

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PMC10253973

A metabolic disease such as diabetes type 2 is characterized by the decreased sensitivity of muscle tissues to fats and insulin, leading to poor blood sugar regulation .

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PMC10582049

Additionally, cells with a percentage of mitochondrial genes higher than 17% were excluded from the analysis.

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PMC9727330

Finally, the flow cytometry assay (BD Accuri 6 Plus) was used to assess the protein levels using a resuspended pellet in 500 µl PBS (Abd El Maksoud et al., 2019b; Hamouda et al., 2021).

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PMC9031474

Natural drimanes and coloratanes, as well as their semi-synthetic derivatives, showed promising results against cancer cell lines with in vitro activities in the low micro- and nanomolar range.

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PMC2193049

Where indicated, the proteasome inhibitor lactacystin (Biomol) was incubated for 15 min with proteasome at 25°C before the addition of the peptide substrates.

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PMC9429973

Results: Most patients begin their medical process through General Practice.

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PMC11659921

C, D) Analysis of TNFSF11 correlation with immune infiltration‐associated cells based on the xCELL method.

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PMC9352806

Surprisingly, worms treated with 100 and 200 μg/mL BMS exhibited anti-aging characterized by increased mean lifespan by 16.64% and 13.83% (Fig. 1H and Table 1, p < 0.001), respectively.

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PMC11754784

The expression of CD80 was tested using flow cytometry to confirm the successful differentiation of M1 macrophages (Supplementary Fig. 37).

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PMC6892818

Bars show mean RLU of 3–4 technical replicates ± SEM.

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PMC7039683

No further copy number analysis was carried out. (

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PMC11592008

Moreover, cell swelling and membrane rupture can occur following the formation of GSDMD pores, resulting in pyroptotic cell death .

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PMC11541409

Imatinib, a drug specifically designed to target the BCR-ABL oncoprotein in chronic myeloid leukemia, has also proven effective for primary GISTs (Fig. 3A).

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PMC4485648

Total protein extracts (50–100 mg/lane) were separated by SDS-PAGE under reducing conditions and blotted onto polyvinylidene fluoride membranes (Immobilon; Millipore, Billerica, MA, USA).

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PMC11714165

One‐factor analysis of variance (ANOVA) was used to examine differences between multiple groups.

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PMC11472639

Participants attended a screening visit and underwent a 12-lead electrocardiogram (ECG) which was reviewed by a cardiologist to confirm eligibility.

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PMC11679033

Obtained results are reported in Table 1, while morphological features of dead cells are shown in Figure 4.

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PMC11388384

Network diagrams were plotted in R using the library iGraph.

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PMC9429973

Only 42.3% had response to the treatment (25/76 complete responses and 11/76 partial responses).

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PMC11675244

However, the loss of APC function causes a constant activation of β-catenin, contributing to both the initiation and progression of colorectal cancer .

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PMC11718031

Efficient and robust cell cultivation is required to ensure the desired and consistent quality of products.

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PMC11301242

Blue data points represent the same genes encoded on ecDNA in the A3KAW cell line. (

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PMC11422497

Cell lysis was carried out using SDS lysis buffer (62.5 mM Tris-HCl, pH 6.8, 2% SDS, and 10% glycerol) at 95 °C for 10 min.

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PMC11794588

Borse et al. showed that lupeol has potent anti-proliferative and apoptotic effects in HeLa cells, reducing cell viability and migration.

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PMC11786704

However, these synthetic substances often come with significant side effects and toxicity issues, such as hepatotoxicity and immunosuppression, thus limiting their widespread clinical application.

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PMC9917080

Each experiment was repeated three times with separate cell cultures.

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PMC11767725

These findings highlight the intricate connections between metabolic disorders, the microbiome, and psoriasis, providing new opportunities for integrated treatment approaches that target both systemic and local factors.

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PMC11200978

In addition to the efficacy of CA alone, the use of adjuvants to increase the lethality of freezing has been well documented in many cancer types, including prostate , kidney , breast , lung , among others .

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PMC9429973

Our model for “high-risk of death” detection classified patients in the test dataset was with AUC 0.816 accuracy (95%CI 0.679-0.912, McNemar’s Test p-value = 0.5), with sensitivity 0.80 and specificity 0.82.

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PMC9429973

Humans have two isoforms of this enzyme (CTPS1 and CTPS2); human genetic studies have identified an essential and non-redundant role for CTPS1 in the proliferation of B and T cells .

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PMC11790599

TSL-induced cell death in SK-BR-3 and ZR-75–1 cells was partially mitigated by EIPA (Figures 4A, B), and cytoplasmic vacuolization was almost entirely prevented when the cells were co-treated with EIPA (Figure 4C).

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PMC9646302

Thus, we hypothesized that LAPTM5 regulates ccRCC via MAPK pathways.

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PMC11397654

Once again, the 3-(trifluoromethyl)aniline derivative 31b did not show particularly high activity levels.

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PMC11243198

< 500, LogP < 5, HBD < 5, HBA < 10) .

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PMC9429973

Aims: To evaluate the safety, tolerability, and efficacy of magrolimab in combination with commonly used myeloma therapies in patients with relapsed/refractory MM (RRMM).

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PMC5673060

Annotation enrichment analysis of phosphoproteins up-regulated in either the PazR or A204 parental cells compared against the human genome using DAVID.

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PMC10933092

Additionally, the mA modification in 5637 BLCA cells mainly occurs in the CAGGC motif, whereas Li et al. (Li et al., 2017) report a GUUCRA motif.

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PMC11412721

Equal numbers of cells of the indicated genotypes were seeded, then cultured for 15 hr with or without CCL21 and counted.

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PMC11082662

It is associated with highest mortality rate among all gynecological cancers, posing a serious threat to women’s lives (1,2).

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PMC10125312

Overall, under the same conditions, cancerous and noncancerous epithelial cell lines have different uptake capabilities, which is also seen between different tissues, compromising the efficacy of PPTT and highlighting the importance of studying more than one cell type to determine the uptake of nanoparticles.

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PMC4839679

The proportion of CE species in every sample was obtained by dividing the total ion intensity (sum of 106 scans) for each CE species by the total ion intensity obtained for all CE species assayed .

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PMC9792775

We found that the expression of JAK2 was not changed but the p-JAK2, p-STAT3 was decreased significantly in the combination treatment (Figure 3), indicating the inactivation of JAK2/STAT3 pathway.

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PMC11745823

It has emerged as a biomarker and prospective target for diagnostic purposes, targeted therapy, as well as prognostic assessment of numerous diseases .

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PMC9429973

The patient with DLBCL after CAR-T therapy had initial clinical response after two Glofitamab cycles.

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PMC10317042

A promoter assay indicated that SOX10 knockdown lowered EWSR1 promoter activity (Fig. 5F).

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PMC9429973

Although the exact mechanism remains to be elucidated, reduced lymphocyte intratumoral infiltration coupled with the formation of neutrophil extracellular traps (or NETosis) have been postulated as endogenous mechanisms for tissue damage and inflammation.

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PMC11732628

The proteins were extracted from the 143B cells using radioimmunoprecipitation (RIPA; Solarbio Technology Co., Ltd., Beijing, China) lysis buffer and the protein concentration was quantified using a bicinchoninic acid (BCA) protein assay kit (Thermo Fisher Scientific Inc.).

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PMC11730311

A peptide library was designed where all positions were systematically substituted into five different amino acids representing different physicochemical properties.

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PMC11656657

In contrast, HOS (Fig. 2A), RD, CT10 (Fig. 2B), RH4, RH41, RH30 (Fig. 2C), A-673 and SK-ES-1 (Fig. 2D), exhibited a significant proportion of GD2-negative cells.

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