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OTAR3088
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BioData-CellLine_annotated

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PMC11599565
SKOV3 and SKOV3 were cultured on a petri dish until they reached a confluency of 50%.
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PMC11541409
Clinical Cancer Research, 2023.
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PMC6684588
The objective of the present study was to evaluate ACE-083 – a novel, FST291-Fc fusion protein currently in clinical development – for its ability to produce focal muscle hypertrophy and increased strength in normal mice and murine models of neuromuscular disease.
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PMC11470381
Migrating cells exhibit distinct polarity characterized by an asymmetric distribution of cellular components along their migratory axis [32–34].
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PMC11806106
As one receptor can activate more than one heterotrimeric G protein, there is a strong amplification of the signal, shifting the EC50 values.
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PMC11765879
RP-HPLC (Waters e2695, UV-PDA 2998 detector, Massachusetts, USA) was used for qualitative and quantitative detection of marker constituents of the extract.
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PMC11547917
The collected specimens were air-dried in the dark at room temperature (RT) and only leaves were ground and used in the extraction process.
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PMC11707577
Toxicity studies in chronic conditions were performed to demonstrate the absence of toxicity of M13EGFR(TNP) and M13EGFR‐CF488A in absence of photostimulation in vivo.
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PMC11365983
Evaluation of cilia length and cilia-mediated pathways in vitro, together with studies in murine mutants, yielded evidence that support a model in which Foxc1 modulates aspects of ciliary function.
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PMC11748618
Each data point (pink) represents a meQTL in the chromosome 1 region in linkage disequilibrium (r = 1) with rsrs72999655-A-G. The vertical bars show whether the meQTL is associated with hypermethylation (red) or hypomethylation (blue).
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PMC5916734
Isolation and purification of FIX involves four chromatographic rounds, without the use of immunoaffinity chromatography.
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PMC10656496
However, in the 10/90 coculture (10% 143B, 90% SAOS2), a remnant population of SAOS2 was still present after 24 days (Fig. 1B, bottom panel).
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PMC11758416
Target cells did not die (T cell isolation and culture).
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PMC11695546
In this study, the GC–MS testing was used to determine the constituents of the oils both before and after treatment by ozone.
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PMC7154001
This systematic review aimed to summarize the research articles relating to the metabolite profiling studies of anticancer drugs (conventional chemical synthetic drugs and targeted small-molecules) and candidate compounds from herbal sources.
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PMC11544122
Primers were used to amplify template DNA encoding FLAG-CXCR4 or FLAG-CXCR4-YFP using Platinum SuperFi DNA polymerase and circularized with KLD enzyme mix.
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PMC11763126
Our results indicate that CBDP1 inhibits ccRCC progression by regulating the USP5/YTHDF2/TRPM3 axis (Fig. 11).
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PMC9587298
Due to the formation of mono- and di-adducts between MGO and phenolic compounds, mainly between cyanidin-3-glucoside and cyanidin-3-sambubioside, the major compounds present in S. nigra berries are able to rapidly trap MGO forming both adducts, which considerably decrease the amount of free MGO that reaches the cells a...
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PMC11585254
Approximately, 70–80% WT receptor was internalized following 30–60 minutes of CXCL13 stimulation.
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PMC11628904
One hour daily washing of the burned region with saline improved burn wound healing and reduced the likelihood of burn wound infection, albeit not to the level of statistical significance.
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PMC11699465
Cells were cultured for 14 days at 37°C to allow colony formation.
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PMC7185206
It is also unknown whether clinical PD-L1 inhibitors bind sPD-L1 fragments equally.
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PMC10818573
During latent EBV infection, the virus is detectable in the nucleus in a ring form, linked to the chromatin of the host genome by the Epstein–Barr nuclear antigen 1 (EBNA1) protein ; genes expressed during latent EBV infections are referred to as latent genes.
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PMC11594588
Shear stress affects G protein activation.
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PMC6163708
However, it is highly probable that most cells were eradicated by apoptosis as it is a well-known consequence of GANT61 treatment.
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PMC11676670
In summary, this study highlights the importance of accurately characterizing new cell lines and carefully selecting a disease model for each research task based on the specific characteristics of the cell line.
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PMC11335267
Since blood glucose fluctuations and insulin can affect food intake and lipid deposition, it is possible that pancreatic dysfunction may contribute to the phenotype described in this study.
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PMC11684269
Targeting T cell metabolism is expected to offer new therapeutic options for kidney disease treatment.
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PMC11742431
Meanwhile, the half degradation concentration (DC50) curves were plotted by western‐blot data (Figure S6), and the DC50 values of KVN and K14N proteins against Survivin protein in 5637 cells were found to be 5.5 µg/mL and 29.0 µg/mL, respectively.
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PMC5311252
In summary, our functional genomics screen indicated that expression of miR-372 and other AAGUGC-containing miRNAs in lung cancer cells results in increased proliferation and increased sensitivity to EGFR inhibitors.
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PMC10840195
Sunitinib resistance and Twist overexpression can activate Wnt/β-catenin signaling pathway and EMT to promote the growth and metastasis of RCC cells.
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PMC11786704
5 The inhibition of the MAPK signaling pathway for wound healing by PC capsules. (
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PMC11658074
Among AT-EVs, 83.42% expressed CD151, and 4.92% expressed APN, whereas among ADSC-EVs, the expression rates were significantly lower, with 1.98% expressing CD151 and only 0.30% expressing APN.
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PMC11078693
Timing: 30 min 3.Prepare 1 M Tris pH 8.0 solution.4.Prepare 10% v/v stock of Triton X-100 in H2O.5.Prepare permeabilization/quenching buffer.
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PMC10443665
One fraction, termed ‘tragacanthic acid’ or bassorin is water insoluble.
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PMC9545474
In conclusion, five 18‐electron phosphine‐containing half‐sandwich metal complexes based on the electron‐deficient [(η‐p‐cymene)Ru(maleonitriledithiolate)] were synthesised and characterised.
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PMC11472639
Previous mouse models have demonstrated that immediately following an individual bout of vigorous running exercise, the frequency of T-cells is elevated in the bone marrow, thus indicating that immune effector cells may have the potential to migrate to bone marrow in response to exercise (Krüger et al., 2008).
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PMC10976516
Table S1 shows an overview of specific features from OVs that were most frequently used against lung cancer in various experimental settings.
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PMC10728200
The ubiquitination of GPX4 protein was measured by CO-IP using an anti-ubiquitin antibody.
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PMC5261804
It only changes the values but won't affect the ordering.
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PMC11185260
Without any treatment, all mice succumbed to their disease before day 77, with a median survival of 56 days.
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PMC11632064
Colored regions were manually generated to highlight enriched networks.
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PMC9545474
No toxicity was observed in preliminary in vivo pilot studies for these two complexes in subcutaneous A2780 and A2780cisR xenograft models, with some evidence of tumour growth delay.
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PMC11757230
Lentiviral vectors were used to transduce the firefly luciferase (fLuc) gene into CLC cells using the pLV[Exp]-Neo-CMV > Luciferase vector, which was constructed and packaged by VectorBuilder (Chicago, IL, USA).
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PMC9250505
NPB also decreased Olaparib IC50 in wild-type Anglne cells by ~120-fold (Supplementary Fig. 2).
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PMC8992508
These proteins are overexpressed in cancer cells, but they are also present in several important tissues where they play a physiological role.
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PMC10728200
In addition, IM promoted the accumulation of Fe in GIST and decreased the GSH/GSSG ratio in a concentration-dependent manner.
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PMC10847511
Similarly, Spearman’s correlation analysis between mutational signature 3 and AUCs (Fig. 5) showed a trend toward positive correlations in 4 of the 10 platinum assays (unadjusted P < 0.05) and 2 (Oxaliplatin 2) of them remained statistically significant (adjusted P < 0.05).
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PMC9429973
Methods: We analysed the levels of hERFE, EPO, hepcidin, and soluble transferrin receptor (sTFR) in a large group of 41 PKD patients equally distributed by gender, age and severity.
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PMC11206251
Moreover, the anti-HCC activity of the PEIM should be studied in vivo, and signaling pathways involved in its effects should be explored to develop the anti-HCC drug.
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PMC10969097
The clinical study with reference number NCT00970021, which began in 2009, was carried out to evaluate the effects of an 82% Agaricus blazei Murril mushroom extract (Andosan™) as a complementary treatment in multiple myeloma patients undergoing high-dose chemotherapy.
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PMC11545737
Inflammasome activation leads to self-cleavage of procaspase-1 which in turn cleaves and activates gasdermin-D (GSDMD), pro-IL-1β and pro-IL18.
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PMC11682172
We conclude that T lymphocytes trigger cancer cells to express proteins including coronin-1A that enable the cancer cells to cross an in vitro BBB.
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PMC11679326
Glycosylation is a complex and multistep process that requires the coordinated work of hundreds of glycosyltransferase enzymes, glycosidases, and glycosylation-related genes, and it affects several cellular compartments.
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PMC7762347
Besides, the protein is significantly involved in the control of the cell-cycle at G2-M checkpoint, induction of DNA repair and apoptosis .
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PMC11461025
Although cancer is the second leading cause of death globally, given the complexity of the disease, there is a pressing need for the discovery of novel drugs that could be used to treat cancer.
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PMC11411004
The gels were thoroughly wetted in the transmembrane solution and transferred to PVDF membranes to remove the effect of nonspecific adsorption.
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PMC8140214
Therefore, new strategies and antioxidants should be implemented inthe treatment of DM.
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PMC10729469
A Representative flow cytometric gating strategy for quantification of total Treg frequencies (CD4+ CD25+ FoxP3+).
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PMC11502327
As a multifunctional system, it can regulate the distribution of packaged drugs in time, space and dose (12).
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PMC11453018
B Gene expression analysis shows changes in proliferation and senescence markers in SKES1 cells following 1, 3, and 7 days of treatment with 1 μM iP300w.
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PMC9429973
The estimated 18 mos RFS and OS were 63% and 73% respectively, for the whole group (Fig. 1B), and the 18 mos OS was 87% and 55% for responders and non-responders, respectively.
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PMC11055443
Measurement of IL-6 and PGE2 cytokines and NO production.
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PMC6190245
Cells were treated with various concentrations of F. gummosa Boiss for 24, 48 and 72 hr.
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PMC10530622
The kidney is a primary target of oxalate toxicity and its main excretory organ .
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PMC11684269
Further, inhibiting JAK/STAT signaling by tofacitinib impaired the survival of Trm cells and restored kidney damage (146).
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PMC11727145
In this work, we aimed to further standardize the DED production method, providing a detailed and simplified description of the de-epidermization processes for small to mid-size batch preparation and long-term preservation to ensure uniform off-the-fridge usability.
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PMC10490530
For the first time, we showed that this luciferase protein can be used as a standalone reporter returning sufficient photonic output required for measurement in vitro and in vivo.
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PMC11709639
However, these approaches challenge bioenergetic processes due to the role mCa plays in metabolic regulation.
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PMC9479186
Cancer-associated cellular pathways analysis by NDUFC1 expression.
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PMC9429973
Avapritinib treatment reduced the proportion of aberrant CD25+ and CD30+ MCs in BMBs by Week 8 and Week 24 (Table).
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PMC9587298
The assay was repeated on different days, 5-times and 4-times, in Caco-2 and HepG2 cells, respectively.
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PMC11204465
With the immunocytochemistry analysis showing increased expression of apoptosis-related proteins of Bax, Caspase-3 and p53 and decreased expression of Bcl-2 protein, the additive nature of the co-proapoptotic activity of AFB1 was revealed .
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PMC8992508
Little inhibitory effect on multidrug resistance-associated protein 1 (MRP1) was showed in the adriamycin (a MRP1 substrate) accumulation test on MRP1-transfected stable HEK293/MRP1 cells.
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PMC11471176
MDA-MB-231 cells were sub cultured for 24 h and MCF-7 for 1 week.
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PMC10759659
a Mutation status of the top 20 mutated genes, including ARID1A, is presented in all three cohorts.
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PMC7868205
The broadening of Bragg’s peaks positioned specifies the formation of smaller sized nanoparticles.
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PMC11495567
The media were then removed, and the cells rinsed with 2 mL 1X wash buffer.
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PMC9429973
Results: B-cell restricted loss of Bcor in Eµ-TCL1 mice significantly expanded leukemic CD5+CD19+ cells in the peripheral blood (PB; p<0.05), spleen (p<0.01), bone marrow (BM; p<0.001), compared to Eµ-TCL1 control mice.
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PMC9429973
When stratified for AML sub-entities, the prognosis of the SF3B1 AML seems to be dominated by the sub-entity.
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PMC9250505
Olaparib treatment of cells increased phosphorylation of CHK1 at Ser345 and CHK2 at Thr383 (normalized to CHK1 and CHK2 protein, respectively).
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PMC11534035
Under these conditions, a notable reduction in PAI1 expression was observed in western blots.
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PMC6337547
Magnesium lithospermate B and ammonium-potassium lithospermate B are magnesium and ammonium-potassium compounds of the tetramer salvianolic acid B. Magnesium lithospermate B has antioxidative , anti-liver injury , and anti-myocardial ischemia-reperfusion injury effects .
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PMC11615101
The paw volume was significantly increased on the 21 day in the CIA group compared to the HC group, and the group treated with siTaxilin showed a decreased paw volume compared to the CIA (Figure 7B) and NS+CIA groups.
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PMC9784246
The anti-L. major results revealed strong growth inhibitory effects of the EtOAc fraction against L. major promastigotes (IC50 27.52 ± 0.7 μg/mL) and axenic amastigotes (29.33 ± 4.86% growth inhibition at 100 μg/mL), while the butanol fraction exerted moderate activity against promastigotes (IC50 73.17 ± 1.62), as comp...
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PMC9429973
Results: PCA analysis revealed that IDH1/2 mutations (R132H, R140Q and R172K) carrying cells show subtle but significant differences in protein and nucleic acids composition in comparison to control cells.
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PMC11703992
Although the previous results revealed that BCL2, a DDIT4+ memory T cell in the GCA group, exhibited heightened protein activity, given that BCL2 is regulated by TNF-α and DDIT4 influences the expression of TNF-α, we elected to examine MCL1, which performs a comparable function to BCL2, to elucidate the impact of DDIT4...
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PMC10831439
Thus, CAR-iNKT cells would represent an elegant way to prevent or treat relapse after allogeneic HCT without causing GVHD.
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PMC11704135
H-NMR spectrum (CDCl3) of compound 10 provided (s, 6H, pyrimidine methyl protons) at 2.22, (s, 1H, aromatic protons of pyrimidine ring) at 7.28 and (m, 5H, aromatic protons) at 7.35–8.82 ppm.
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PMC11477621
H NMR (600 MHz, CDCl3) δ 7.24–7.21 (m, 1H), 7.08 (t, J = 2.0 Hz, 1H), 6.26 (dd, J = 4.4, 2.4 Hz, 1H), 4.31 (t, J = 7.3 Hz, 2H), 4.12 (q, J = 7.1 Hz, 2H), 2.28 (t, J = 7.5 Hz, 2H), 1.77–1.71 (m, 2H), 1.62–1.60 (m, 2H), 1.38–1.29 (overlap, 4H), 1.25 (t, J = 7.1 Hz, 3H).
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PMC9884169
RNA-sequence, RT-PCR, and Western Blot were used to analyze the mechanism of MCT4 of ferroptosis and autophagy.
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PMC10713411
In addition, the PRPCDGs risk signature was adopted in TCGA-KIRP cohort and showed a reliable prediction performance (Figure 3G).
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PMC11754291
As expected, the UVA light positive control at 15 mW/cm and 20 J/cm showed a more pronounced reduction in metabolic activity, dropping to 0.60 ± 0.031 by day 7, also relative to its sham.
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PMC9341513
The green block and dashed lines show the position of the inserted region.
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PMC11585587
Each set of experiments was repeated three times independently, and the results were presented as the mean ± standard deviation.
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PMC3035438
The proportion of cells containing sequence alterations compared to the parental chimera CX13 clone was determined by sequence analysis: GC = gene conversion tracts, PM = point mutations, none = no alteration.
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PMC11770130
c KO efficiency and specificity of the Ntsr2 gene (n = 3–6).
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PMC11786767
The interactions between mitotic chromosomes and microtubules are crucial for chromosome organization, positioning, and movement during the cell cycle (57, 58).
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PMC8481254
The results proved that YAP could interact with OGT, which was consistent with our previous research results.
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PMC11354239
CD16 down-modulation represents a well-known mechanism under conditions of chronic CD16 engagement.
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