OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11679892	All statistical analyses were performed using SPSS software (Statistical Package for the Social Sciences version 21, Chicago, IL, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9646302	This study had some limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "had", "some", "limitations", "." ] } ]
PMC11585254	Data represent the mean ± S.D. from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "S.D.", "from", "three", "independent", "experiments", ...
PMC11055323	We tested this hypothesis with the compound A-485, a highly selective and drug-like CBP/p300 catalytic inhibitor , to decrease the over-deposited H3K27ac modification in SS18-SSX condensates (Supplementary Fig. 13a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	We observed a clear advantage of using MR-MEGA over METAL for GWAS meta-analysis in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "a", "clear", "advantage", "of", ...
PMC11078693	Kimwipes can also be used.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kimwipes", "can", "also", "be", "used", "." ] } ]
PMC11770130	g Scheme of the establishment of CerS2 mouse strain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Scheme", "of", "the", "establishment", "of", "CerS2", "mouse", "strain", "." ] } ]
PMC9429973	In the 1:1 matched population (N=418, 209 patients treated with tisa-cel and 209 patients treated with axi-cel), the best ORR/CRR was 66/42% versus 80/60% for patients treated with tisa-cel compared with axi-cel, respectively (P<0.001 for both ORR and CRR comparisons).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11659921	I, J) Altered ability to promote angiogenesis after inhibition of TNFSF11 in A2780 and HEY cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "I", ",", "...
PMC11389534	Apart from RPL26 UFMylation mediated ER‐ribosome‐associated quality control (ER‐RQC) system, the control of ER proteostasis by UFMylation is achieved through several other mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10840195	The cells were inoculated in 6-well plates one day in advance, and then trypsin without EDTA was used for digestion and collection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	Aims: We sought to define patient profiles correlated with manufacturing and clinical endpoints in RRMM patients treated with ide-cel in clinical trials using unsupervised clustering and multivariate machine learning across multiple key variable domains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11552389	Overexpression studies were conducted using GV141 plasmids carrying FOXN3 expression vectors in A375 cells, while downexpression studies utilized FOXN3-specific shRNA-expressing plasmids (shR1 and shR2) in A875 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	Total proteins from cells were extracted using PRO-PREP protein extraction solution (iNtRON Biotechnology Inc, Korea) supplemented with sodium fluoride (Honeywell Riedel-de-Haen, USA) and sodium orthovanadate (Sigma-Aldrich, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10932641	More and more research has found that miRNA has close interactions with lncRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "and", "more", "research", "has", "found", "that", "miRNA", "h...
PMC8922418	For this purpose, in 2013, Ebina et al. reported that HIV-1 gene expression was successfully suppressed in the Jurkat cell line by CRISPR/SpCas9 mediated targeting of the NF-κB cassettes located in the U3 region and the TAR sequence in the R region of LTR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC9096373	The maximum diameter (dmax) and minimum diameter (dmin) of tumors in each group was measured using a vernier caliper every 2 days starting from the first day post-administration until the 25th day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	Starting at 4 h incubation time, fluorescence-positive cells also increased among controls, albeit without statistical significance, and in both PBMCs and Jurkat cells, the γH2AX signal in response to ETP and DOX seemed to decline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC11650848	Polymorphic base located between the fifth and sixth CpG site (asterisk) corresponds with the rs365052.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polymorphic", "base", "located", "between", "the"...
PMC11747885	SGI-1027 (1) is a quinoline-based non-nucleoside that selectively inhibits DNA methyltransferases (DNMTs) with IC50 values of 6–13 μM and has low cytotoxicity.1 is composed of four core aromatic moieties, including an aminopyrimidine group (R) and a quinoline moiety (R), which are critical for its interaction with DNMT...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	Missense mutations in MAN2B1 can be classified into two primary categories: Active site-disrupting mutations: These genetic alterations result in the production of translationally defective proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10849234	PLB-985 cells were treated with 50 μl of the concentrated lentivirus and 2 mg/ml Polybrene (Sigma; catalog # H9268-5G).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11371747	As to the NSCLC cell lines, H292 and H460 cells exhibited the highest and lowest expression relative to CEM cells, with values of 8 and 1, respectively (Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O"...
PMC11429241	The cells were maintained at 37 °C in a humidified atmosphere at 5% CO2 and were regularly passaged after they reached confluence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11753949	In order to identify the region(s) within synaptopodin responsible for its property to crosslink actin bundles to the ER, we generated several truncation mutants of this protein and tested them for their property to generate the actin-rich ER-associated structures described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	Continuous variables are given as mean ± standard deviation, and categorical variables are given as a number and percentage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Continuous", "variables", "a...
PMC9429973	These observations were consistent with previous reports in non-molecularly defined HR subgroups from KarMMa and the hypothesis that CAR T MOA may have a broader spectrum of clinical activity across more diverse molecular subtypes of pts, especially existing HR subsets; this could be a consideration as CAR Ts are devel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	Indeed, Enoxacin treatment enhanced siREN-mediated suppression of renilla expression (up to three-fold), concluding that a similar RNAi-enhancing effect is present in CEM-SS cells as described (Figure S1c, ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11765879	Different concentrations were used ranging from 10 to 100 µM for 48 h. The percentage of cell viability was significantly reduced in both cell lines (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	Of note, USP14 expression has been related to patient survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "USP14", "expression", "has", "been", "related", "to", "patient", ...
PMC9429973	According to Hans algorithm, 19 (31%) GCB origin, 42 (68%) were non-GCB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "Hans", ...
PMC11615828	Transfected COS7 cells, HeLa cells, and MDCK cells were imaged at intervals of 2.5 or 5 s. Vesicle trajectories were analyzed using Fiji software with the Trackmate plugin.	[ { "tags": [ "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11023271	A. Heated FBS retained its ability to down-regulate RIPK4 mRNA in HaCaT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A.", "Heated", "FBS", "retained", "its", "ability", "to", "down-re...
PMC8992508	Compound 62 (HM30181) has been recently identified as a third-generation P-gp inhibitor [Figure 12].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "62", "(", "HM30181", ")", ...
PMC11248911	A model was used for predicting the validation test set compounds biological activity (External validation).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "model", "was", "used", "for", "predict...
PMC9429973	Summary/Conclusion: The above steps provide a practical outline, which may vary depending on the aims.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "The", "above", "steps"...
PMC11291490	Vaccination is a pivotal strategy for prevention and containment of virus transmission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vaccination", "is", "a", "pivotal", "strategy", "for", "prevention", "and", "con...
PMC11643361	This large variety of different substituents, heterocycles, and central atoms that can be used makes scorpionates a very diverse family of ligands with different properties and activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765243	Genetic models complement studies on the effect of specific inhibitors and thus, using a conditional transgenic mouse model, we showed here the implication of PI3K-p110α in the intracell signaling and differentiation of thymocytes, particularly in the DP and SP CD4 stages and in the differentiation of thymic Tregs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	Data normalization was executed using the GeneSpring GX program (Agilent Technologies), applying the quantile algorithm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "normalization", "was", "executed", ...
PMC11533140	Isoform selectivity study of the selected compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isoform", "selectivity", "study", "of", "the", "selected", "compounds", "." ] } ]
PMC11435360	The total tumor burden was represented as the bladder wall volume, which was a modification from a previously described method .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "total", "t...
PMC11799978	Clinical findings demonstrate that the number, morphology, and functions of CAFs in tumors are correlated with the patients’ survival and treatment outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10965680	Due to the geographical location and different living environments, closed and natural mating conditions have existed for a long time, and as a result of the low intensity of artificial selection, these breeds are not very distinct from each other.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	The AUC was 0.83, indicating strong association.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "AUC", "was", "0.83", ",", "indicating", "strong", "association", "." ] } ]
PMC11766174	It should be noted that, in these experiments, normalization per million was achieved by extrapolation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "should", "be", "noted", "that", ",", ...
PMC11490153	Further studies have demonstrated that hypoxia can either enhance or diminish drug effectiveness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "have", "demonstrated", "that", "hypoxia", "can", "eit...
PMC9429973	The TL in BM-MSC was not influenced by age (p=0.360), disease severity, and other hematological parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TL", "in", "BM-...
PMC11640555	These events are also controlled and driven by specific markers, such as Ki-67 and TGF-β, that are considered prognostic markers in the GBM filed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Together with low transcriptional levels of iron genes, 697 viability did not change with different FAC treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", "with", "low", "transcriptional",...
PMC10813895	However, all isoforms retain the ETS DNA-binding domain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "all", "isoforms", "retain", "the", "ETS", "DNA-binding", "domain", "." ] } ]
PMC11694066	All uncropped images of the blots included in this study are also available in Supplementary information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "uncropped", "images", "of", "the", "blots", ...
PMC11799620	Thus, more attention should be given to investigating this plant’s capacities and isolating and identifying its bioactive molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "more", "a...
PMC6742971	We adoptively transferred mixtures of a low avidity T cell clone with a high avidity T cell clone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "adoptively", "transferred", "mixtures"...
PMC8009078	The average RMSF value can give an idea about the fluctuation of the amino residues during the simulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "RMSF", "value", "can...
PMC11298021	TurboFect reagent was utilized to transfect miR-3143, miR-3182, and their respective combinations into Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "TurboFect", "reagent", "was", "utilized", ...
PMC11705630	The proliferation rate was assessed at 0, 24, 48, and 96 h using Cell Counting Kit-8 (CCK8) (Dojindo Molecular Technologies, Kumamoto, Japan) assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11534377	In preclinical models, this synergistic approach has improved cancer treatment efficacy, suggesting it could be more effective against NSCLC by utilizing their complementary mechanisms of action .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	Each amino acid’s features are replicated across the corresponding positions in the matrix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "amino", "acid", "’s", "features", "are", "replicated", "...
PMC11638764	DOI: 10.22002/sfn6b-q2r37	[ { "tags": [ "O", "O", "O" ], "tokens": [ "DOI", ":", "10.22002/sfn6b-q2r37" ] } ]
PMC11721064	A and B IF staining (A) and quantification of CK12 + cells (B) showed that Stattic treatment significantly decreased the population of CK12 + cells (CK12: p < 0.001) (scale bar = 50 μm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8345486	RPMI-1640 ATTC medium (ATCC-30-2001) and FBS (ATCC-30-2025) for the initiation of OVCAR-3 cell culture were purchased from LGC Standards (Teddington, UK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC9960565	Fluorescence: λex = 380 nm, λem, max = 440 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", ":", "λex", "=", "380", "nm", ",", "λem", ",", "...
PMC9504875	This region contains the SPRY domain, suggesting that interaction of RIG-I with TRIM25 is competitively inhibited by N protein (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11731614	The HFD keratinocytes had impaired wound healing during the 3 days of observation (Supplemental Fig. 1A-B), consistent with what has been shown in scratch assays with high glucose exposure (Dam, 2017) and what is observed in diabetic patients (Nowak et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	PlatE cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM, Corning) and supplemented with 10% FBS, penicillin-streptomycin, sodium pyruvate, Hepes, NEAA, and 2-mercaptoethanol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	An additional study has reported that β-elemene, when administered for the treatment of xenograft animal models, does not induce ocular toxicity in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	There were no differences with the intensity of conditioning (Myeloblative 78.5% and reduced intensity 72%) although the highest severe cases was observed of myeloablative unrelated transplant (66.5%; p-value 0.03).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	When the members of the Bcl-2 gene family are not properly regulated, it can hinder cell apoptosis and elevate the survival rate of tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11367146	Table 4MMPBSA analysis of docked complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "4MMPBSA", "analysis", "of", "docked", "complex", "." ] } ]
PMC8481254	Additionally, we found that OGT, the only endogenous enzyme that catalyzes O-GlcNAcylation, was positively regulated by CDK19 (Fig. 5A–C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8316344	Cell proliferation and DNA damage were tested by a cell counting kit-8 (CCK-8, HY-K0301, MCE) and DNA damage assay kit (ab211154, Abcam), respectively, according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	Western blot of apoptosis-related proteins Bax and Bcl-2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "of", "apoptosis-related", "proteins", "Bax", "and", "Bcl-2", ".", "(" ] } ]
PMC11705862	Sections stained against AT8, IRIS-1 and IRIS-2 were analyzed using confocal microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sections", "stained", "against", "AT8", ",", "IRIS-1", "and", "IRIS-2", ...
PMC11711345	Otherwise, regional drug targeting in the gastrointestinal tract may be considered a reliable pharmaceutical approach in other cancer therapies, given the moderate-to-high probability of metabolisms by cytochromes P450.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	Representative images of 4-HNE detected in the removed tumor tissues by immunohistochemistry staining of four groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "4-HNE", "detected", ...
PMC10728200	Although TKIs have been developed to the fourth generation, acquired drug resistance remains a problem.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "TKIs", "have", "been", "developed", "to", ...
PMC9444294	HSSYII and U2OS cells were seeded in 8-well chamber slides and grown for 24h.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HSSYII", "and", "U2OS", "cells", "were", "seeded", "...
PMC9429973	PCA analysis of matched samples stored in either EDTA or PAXgene tubes showed high similarity in gene expression, while the correlation between TPM expression values and decay constants indicates that genes over-abundant in EDTA samples are not dominated by slow-degrading transcripts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	At the same time, the antagonist of P2Y receptors (MRS-2179) suppressed signals for application of 2.5 µg/mL SeNP in almost all cells (Figure 5B) and only in single cells were low-amplitude Ca signals recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179	U2OS cells expressing (A) EGFP-FUS(FL) and (B) TAF15(IDR)-Halo-FTH1, and (C) an A673 cell expressing endogenous EWS::FLI1-Halo are imaged using confocal fluorescence microscopy before and after 10 min of fixation with 4% paraformaldehyde (PFA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC9429973	Young adults (20-39 yr) with BL showed great improvement (+21%) with survival progressing towards the level seen in children.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Spheroids were then enzymatically and mechanically dissociated using trypsin EDTA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroids", "were", "then", "enzymatically", "and", "mechanically", "dissociated", "using", "trypsin",...
PMC8041314	This downsized the compound library to 25,060 potential multitarget ABCB1, ABCC1, and ABCG2 inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "downsized", "the", "compound", "library", "to"...
PMC7685376	Top 15 of pathway enrichment.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top", "15", "of", "pathway", "enrichment", "." ] } ]
PMC11487720	Fig. 4Dramatic increases in cell thickness during apoptosis, but not BCD, determined by time-lapse holographic microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "4Dramatic", "increases", "in", ...
PMC11476004	In our study, the St. Bernard dogs and Bernese mountain dogs in which tumours were diagnosed and the level of genome instability was tested were large, Molosser-type dogs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Unfortunately, clinical developments of OV monotherapies have stalled in part due to frequent tumor resistance to infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "clinical", "developmen...
PMC11388384	Sender cells were induced to secrete SHH-Halo for 16 to 24 h before imaging SHH-Halo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sender", "cells", "were", "induced", "to", "secrete", "SHH-...
PMC10965680	Linkage disequilibrium (LD) was assessed using the r statistic and PopLDdecay v3.40 software (Hudson et al., 1992), which considered the physical distance between pairwise SNPs with default settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	a–f Expression levels of UPR-related genes (a, b) and proteins (c–f, n = 3) in the adipose tissues of control and Ntsr2 AKO mice; n = 3–6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Stage at diagnosis was not significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stage", "at", "diagnosis", "was", "not", "significant", "." ] } ]
PMC11489351	For example, we identified a small number of TFs and cotranscriptional activators with pH-sensitive expression based on the differentially regulated RNA-Seq dataset (Fig. 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	Afterwards, the cells were detached and enumerated using a haemocytometer and microscope (inverted light).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Afterwards", ",", "the", "cells", "were", "...
PMC11473843	Representative hematoxylin & eosin (H&E) staining (left) and quantification of the average tumor size (middle) and tumor number (right) of lung tissue from LSL-Kras;p53 mice treated as in (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699178	To further elucidate the signaling pathway through which GEM exerts its anticancer effects, ovarian cancer cells treated with GEM were subjected to high-throughput sequencing, and the resulting transcriptome count matrix was analyzed using edgeR software, leading to the identification of 308 DEGs, with 227 significantl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10212663	A flow chart of the whole procedure of this work.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "flow", "chart", "of", "the", "whole", "procedure", "of", "this", "work", "." ] ...
PMC11637284	kDNA area measurements were performed on three days tetracycline-induced cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "kDNA", "area", "measurements", "were", "performed", "on", "three", "days", "tetracycline-induced", ...
PMC10887351	In the urinary bladder, the sympathetic-mediated relaxation in humans, monkeys, and dogs was dependent on β3-AR activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "urinary", ...
PMC11247842	The predicted regulatory elements from ATAC-seq, H3K4me3, H3K27me3, H3K27ac, H3K4me1, and CTCF were retrieved from a recently published data set .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11679892

All statistical analyses were performed using SPSS software (Statistical Package for the Social Sciences version 21, Chicago, IL, USA).

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PMC9646302

This study had some limitations.

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PMC11585254

Data represent the mean ± S.D. from three independent experiments.

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PMC11055323

We tested this hypothesis with the compound A-485, a highly selective and drug-like CBP/p300 catalytic inhibitor , to decrease the over-deposited H3K27ac modification in SS18-SSX condensates (Supplementary Fig. 13a).

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PMC11247842

We observed a clear advantage of using MR-MEGA over METAL for GWAS meta-analysis in this study.

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PMC11078693

Kimwipes can also be used.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kimwipes", "can", "also", "be", "used", "." ] } ]

PMC11770130

g Scheme of the establishment of CerS2 mouse strain.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Scheme", "of", "the", "establishment", "of", "CerS2", "mouse", "strain", "." ] } ]

PMC9429973

In the 1:1 matched population (N=418, 209 patients treated with tisa-cel and 209 patients treated with axi-cel), the best ORR/CRR was 66/42% versus 80/60% for patients treated with tisa-cel compared with axi-cel, respectively (P<0.001 for both ORR and CRR comparisons).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11659921

I, J) Altered ability to promote angiogenesis after inhibition of TNFSF11 in A2780 and HEY cell lines. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "I", ",", "...

PMC11389534

Apart from RPL26 UFMylation mediated ER‐ribosome‐associated quality control (ER‐RQC) system, the control of ER proteostasis by UFMylation is achieved through several other mechanisms.

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PMC10840195

The cells were inoculated in 6-well plates one day in advance, and then trypsin without EDTA was used for digestion and collection.

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PMC9429973

Aims: We sought to define patient profiles correlated with manufacturing and clinical endpoints in RRMM patients treated with ide-cel in clinical trials using unsupervised clustering and multivariate machine learning across multiple key variable domains.

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PMC11552389

Overexpression studies were conducted using GV141 plasmids carrying FOXN3 expression vectors in A375 cells, while downexpression studies utilized FOXN3-specific shRNA-expressing plasmids (shR1 and shR2) in A875 cells.

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PMC11759543

Total proteins from cells were extracted using PRO-PREP protein extraction solution (iNtRON Biotechnology Inc, Korea) supplemented with sodium fluoride (Honeywell Riedel-de-Haen, USA) and sodium orthovanadate (Sigma-Aldrich, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10932641

More and more research has found that miRNA has close interactions with lncRNA.

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PMC8922418

For this purpose, in 2013, Ebina et al. reported that HIV-1 gene expression was successfully suppressed in the Jurkat cell line by CRISPR/SpCas9 mediated targeting of the NF-κB cassettes located in the U3 region and the TAR sequence in the R region of LTR.

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PMC9096373

The maximum diameter (dmax) and minimum diameter (dmin) of tumors in each group was measured using a vernier caliper every 2 days starting from the first day post-administration until the 25th day.

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PMC11592837

Starting at 4 h incubation time, fluorescence-positive cells also increased among controls, albeit without statistical significance, and in both PBMCs and Jurkat cells, the γH2AX signal in response to ETP and DOX seemed to decline.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC11650848

Polymorphic base located between the fifth and sixth CpG site (asterisk) corresponds with the rs365052.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Polymorphic", "base", "located", "between", "the"...

PMC11747885

SGI-1027 (1) is a quinoline-based non-nucleoside that selectively inhibits DNA methyltransferases (DNMTs) with IC50 values of 6–13 μM and has low cytotoxicity.1 is composed of four core aromatic moieties, including an aminopyrimidine group (R) and a quinoline moiety (R), which are critical for its interaction with DNMT...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11707832

Missense mutations in MAN2B1 can be classified into two primary categories: Active site-disrupting mutations: These genetic alterations result in the production of translationally defective proteins.

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PMC10849234

PLB-985 cells were treated with 50 μl of the concentrated lentivirus and 2 mg/ml Polybrene (Sigma; catalog # H9268-5G).

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PMC11371747

As to the NSCLC cell lines, H292 and H460 cells exhibited the highest and lowest expression relative to CEM cells, with values of 8 and 1, respectively (Figure 6A).

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PMC11429241

The cells were maintained at 37 °C in a humidified atmosphere at 5% CO2 and were regularly passaged after they reached confluence.

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PMC11753949

In order to identify the region(s) within synaptopodin responsible for its property to crosslink actin bundles to the ER, we generated several truncation mutants of this protein and tested them for their property to generate the actin-rich ER-associated structures described above.

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PMC11679892

Continuous variables are given as mean ± standard deviation, and categorical variables are given as a number and percentage.

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PMC9429973

These observations were consistent with previous reports in non-molecularly defined HR subgroups from KarMMa and the hypothesis that CAR T MOA may have a broader spectrum of clinical activity across more diverse molecular subtypes of pts, especially existing HR subsets; this could be a consideration as CAR Ts are devel...

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PMC11755467

Indeed, Enoxacin treatment enhanced siREN-mediated suppression of renilla expression (up to three-fold), concluding that a similar RNAi-enhancing effect is present in CEM-SS cells as described (Figure S1c, ).

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PMC11765879

Different concentrations were used ranging from 10 to 100 µM for 48 h. The percentage of cell viability was significantly reduced in both cell lines (Figure 4).

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PMC11489175

Of note, USP14 expression has been related to patient survival.

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PMC9429973

According to Hans algorithm, 19 (31%) GCB origin, 42 (68%) were non-GCB.

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PMC11615828

Transfected COS7 cells, HeLa cells, and MDCK cells were imaged at intervals of 2.5 or 5 s. Vesicle trajectories were analyzed using Fiji software with the Trackmate plugin.

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PMC11023271

A. Heated FBS retained its ability to down-regulate RIPK4 mRNA in HaCaT cells.

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PMC8992508

Compound 62 (HM30181) has been recently identified as a third-generation P-gp inhibitor [Figure 12].

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PMC11248911

A model was used for predicting the validation test set compounds biological activity (External validation).

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PMC9429973

Summary/Conclusion: The above steps provide a practical outline, which may vary depending on the aims.

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PMC11291490

Vaccination is a pivotal strategy for prevention and containment of virus transmission.

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PMC11643361

This large variety of different substituents, heterocycles, and central atoms that can be used makes scorpionates a very diverse family of ligands with different properties and activities.

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PMC11765243

Genetic models complement studies on the effect of specific inhibitors and thus, using a conditional transgenic mouse model, we showed here the implication of PI3K-p110α in the intracell signaling and differentiation of thymocytes, particularly in the DP and SP CD4 stages and in the differentiation of thymic Tregs.

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PMC11534377

Data normalization was executed using the GeneSpring GX program (Agilent Technologies), applying the quantile algorithm.

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PMC11533140

Isoform selectivity study of the selected compounds.

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PMC11435360

The total tumor burden was represented as the bladder wall volume, which was a modification from a previously described method .

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PMC11799978

Clinical findings demonstrate that the number, morphology, and functions of CAFs in tumors are correlated with the patients’ survival and treatment outcome.

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PMC10965680

Due to the geographical location and different living environments, closed and natural mating conditions have existed for a long time, and as a result of the low intensity of artificial selection, these breeds are not very distinct from each other.

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PMC4112127

The AUC was 0.83, indicating strong association.

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PMC11766174

It should be noted that, in these experiments, normalization per million was achieved by extrapolation.

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PMC11490153

Further studies have demonstrated that hypoxia can either enhance or diminish drug effectiveness.

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PMC9429973

The TL in BM-MSC was not influenced by age (p=0.360), disease severity, and other hematological parameters.

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PMC11640555

These events are also controlled and driven by specific markers, such as Ki-67 and TGF-β, that are considered prognostic markers in the GBM filed.

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PMC9429973

Together with low transcriptional levels of iron genes, 697 viability did not change with different FAC treatments.

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PMC10813895

However, all isoforms retain the ETS DNA-binding domain.

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PMC11694066

All uncropped images of the blots included in this study are also available in Supplementary information.

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PMC11799620

Thus, more attention should be given to investigating this plant’s capacities and isolating and identifying its bioactive molecules.

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PMC6742971

We adoptively transferred mixtures of a low avidity T cell clone with a high avidity T cell clone.

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PMC8009078

The average RMSF value can give an idea about the fluctuation of the amino residues during the simulation.

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PMC11298021

TurboFect reagent was utilized to transfect miR-3143, miR-3182, and their respective combinations into Jurkat cells.

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PMC11705630

The proliferation rate was assessed at 0, 24, 48, and 96 h using Cell Counting Kit-8 (CCK8) (Dojindo Molecular Technologies, Kumamoto, Japan) assay.

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PMC11534377

In preclinical models, this synergistic approach has improved cancer treatment efficacy, suggesting it could be more effective against NSCLC by utilizing their complementary mechanisms of action .

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PMC11802929

Each amino acid’s features are replicated across the corresponding positions in the matrix.

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PMC11638764

DOI: 10.22002/sfn6b-q2r37

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PMC11721064

A and B IF staining (A) and quantification of CK12 + cells (B) showed that Stattic treatment significantly decreased the population of CK12 + cells (CK12: p < 0.001) (scale bar = 50 μm).

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PMC8345486

RPMI-1640 ATTC medium (ATCC-30-2001) and FBS (ATCC-30-2025) for the initiation of OVCAR-3 cell culture were purchased from LGC Standards (Teddington, UK).

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PMC9960565

Fluorescence: λex = 380 nm, λem, max = 440 nm.

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PMC9504875

This region contains the SPRY domain, suggesting that interaction of RIG-I with TRIM25 is competitively inhibited by N protein (Figure 4).

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PMC11731614

The HFD keratinocytes had impaired wound healing during the 3 days of observation (Supplemental Fig. 1A-B), consistent with what has been shown in scratch assays with high glucose exposure (Dam, 2017) and what is observed in diabetic patients (Nowak et al., 2021).

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PMC11777207

PlatE cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM, Corning) and supplemented with 10% FBS, penicillin-streptomycin, sodium pyruvate, Hepes, NEAA, and 2-mercaptoethanol.

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PMC11727062

An additional study has reported that β-elemene, when administered for the treatment of xenograft animal models, does not induce ocular toxicity in mice.

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PMC9429973

There were no differences with the intensity of conditioning (Myeloblative 78.5% and reduced intensity 72%) although the highest severe cases was observed of myeloablative unrelated transplant (66.5%; p-value 0.03).

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PMC11409031

When the members of the Bcl-2 gene family are not properly regulated, it can hinder cell apoptosis and elevate the survival rate of tumor cells.

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PMC11367146

Table 4MMPBSA analysis of docked complex.

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PMC8481254

Additionally, we found that OGT, the only endogenous enzyme that catalyzes O-GlcNAcylation, was positively regulated by CDK19 (Fig. 5A–C).

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PMC8316344

Cell proliferation and DNA damage were tested by a cell counting kit-8 (CCK-8, HY-K0301, MCE) and DNA damage assay kit (ab211154, Abcam), respectively, according to the manufacturer’s instructions.

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PMC11792888

Western blot of apoptosis-related proteins Bax and Bcl-2. (

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PMC11705862

Sections stained against AT8, IRIS-1 and IRIS-2 were analyzed using confocal microscopy.

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PMC11711345

Otherwise, regional drug targeting in the gastrointestinal tract may be considered a reliable pharmaceutical approach in other cancer therapies, given the moderate-to-high probability of metabolisms by cytochromes P450.

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PMC11536589

Representative images of 4-HNE detected in the removed tumor tissues by immunohistochemistry staining of four groups.

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PMC10728200

Although TKIs have been developed to the fourth generation, acquired drug resistance remains a problem.

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PMC9444294

HSSYII and U2OS cells were seeded in 8-well chamber slides and grown for 24h.

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PMC9429973

PCA analysis of matched samples stored in either EDTA or PAXgene tubes showed high similarity in gene expression, while the correlation between TPM expression values and decay constants indicates that genes over-abundant in EDTA samples are not dominated by slow-degrading transcripts.

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PMC8389560

At the same time, the antagonist of P2Y receptors (MRS-2179) suppressed signals for application of 2.5 µg/mL SeNP in almost all cells (Figure 5B) and only in single cells were low-amplitude Ca signals recorded.

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PMC9817179

U2OS cells expressing (A) EGFP-FUS(FL) and (B) TAF15(IDR)-Halo-FTH1, and (C) an A673 cell expressing endogenous EWS::FLI1-Halo are imaged using confocal fluorescence microscopy before and after 10 min of fixation with 4% paraformaldehyde (PFA).

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PMC9429973

Young adults (20-39 yr) with BL showed great improvement (+21%) with survival progressing towards the level seen in children.

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PMC11599565

Spheroids were then enzymatically and mechanically dissociated using trypsin EDTA.

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PMC8041314

This downsized the compound library to 25,060 potential multitarget ABCB1, ABCC1, and ABCG2 inhibitors.

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PMC7685376

Top 15 of pathway enrichment.

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PMC11487720

Fig. 4Dramatic increases in cell thickness during apoptosis, but not BCD, determined by time-lapse holographic microscopy.

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PMC11476004

In our study, the St. Bernard dogs and Bernese mountain dogs in which tumours were diagnosed and the level of genome instability was tested were large, Molosser-type dogs.

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PMC9065483

Unfortunately, clinical developments of OV monotherapies have stalled in part due to frequent tumor resistance to infection.

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PMC11388384

Sender cells were induced to secrete SHH-Halo for 16 to 24 h before imaging SHH-Halo.

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PMC10965680

Linkage disequilibrium (LD) was assessed using the r statistic and PopLDdecay v3.40 software (Hudson et al., 1992), which considered the physical distance between pairwise SNPs with default settings.

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PMC11770130

a–f Expression levels of UPR-related genes (a, b) and proteins (c–f, n = 3) in the adipose tissues of control and Ntsr2 AKO mice; n = 3–6.

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PMC9429973

Stage at diagnosis was not significant.

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PMC11489351

For example, we identified a small number of TFs and cotranscriptional activators with pH-sensitive expression based on the differentially regulated RNA-Seq dataset (Fig. 7A).

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PMC11551844

Afterwards, the cells were detached and enumerated using a haemocytometer and microscope (inverted light).

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PMC11473843

Representative hematoxylin & eosin (H&E) staining (left) and quantification of the average tumor size (middle) and tumor number (right) of lung tissue from LSL-Kras;p53 mice treated as in (A).

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PMC11699178

To further elucidate the signaling pathway through which GEM exerts its anticancer effects, ovarian cancer cells treated with GEM were subjected to high-throughput sequencing, and the resulting transcriptome count matrix was analyzed using edgeR software, leading to the identification of 308 DEGs, with 227 significantl...

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PMC10212663

A flow chart of the whole procedure of this work.

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PMC11637284

kDNA area measurements were performed on three days tetracycline-induced cells.

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PMC10887351

In the urinary bladder, the sympathetic-mediated relaxation in humans, monkeys, and dogs was dependent on β3-AR activation .

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PMC11247842

The predicted regulatory elements from ATAC-seq, H3K4me3, H3K27me3, H3K27ac, H3K4me1, and CTCF were retrieved from a recently published data set .

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