OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11371627	Electrophysiological investigations revealed axonal polyneuropathy with motor and sensory involvement, fasciculations and pathological spontaneous activity but formally normal motor unit action potentials (MUPs) in left vastus muscle, left tibial anterior muscle and left gastrocnemius muscle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543935	Upscaling the hydrogel would further enhance its image quality and the size also limits potential MR techniques like the thermometry shown in Fig. 3A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7039683	Both of these human non-coding elements have periderm enhancer activity in zebrafish embryos.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "of", "these", "human", "non-coding", "elements", "have", "periderm"...
PMC11509224	Pseudoaxinella is another genus of sponge that has produced only one diterpene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pseudoaxinella", "is", "another", "genus", "of", "sponge", "that", "has", "produ...
PMC11739504	Data were collected from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "collected", "from", "three", "independent", "experiments", "." ] } ]
PMC9268620	The treatments were carried out in 60 mm petri dishes (Nunc) with a working volume of 5 mL. Briefly, cells with a density of 1 × 10 cells/mL were treated with 30, 10, 3, and 1 µg/mL of nordamnacanthal and damnacanthal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	RAO-1 is a human mammary epithelial cell (HMEC) line obtained from healthy individuals undergoing reduction mammoplasty and was immortalized by transduction with the catalytic subunit of telomerase (hTERT) after passage through stasis.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11518702	These include N-terminal myristoylation and palmitoylation sites; four modulated central phospho-tyrosine (pY) motifs (with BCR-activated SYK as an indicated phosphorylating kinase); a validated DDpY107ENV binding site for GRB2 docking; a validated C-terminal PDZ-RhoGEF binding motif (PBM); and an H91 site demonstrated...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470999	First, we analyzed the expression levels of CIP2A in normal nevus samples and melanoma in The Cancer Genome Atlas (TCGA) and found that its mRNA was upregulated in melanoma (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5574817	HEK293 cells were suspended in an appropriate volume of ice-cold Opti-MEM® (Gibco, USA) electroporation buffer.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", "cells", "were", ...
PMC7452526	The mixture was kept under stirring at room temperature for almost half an hour to ensure the homogeneous reduction process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", ...
PMC11267830	Our research also revealed that in HUT78 and 6T-cem cells, the mRNA expression of DCAF15 is similar to that in other T-ALL cells, and RBM39 can be significantly degraded after treatment with indisulam.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11763111	Ficoll-Paque (LDS1075) was used to layer peripheral blood, and density gradient centrifugation was used to separate peripheral blood mononuclear cells (PBMCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11352311	To confirm this, we used Western blotting to examine the changes in the protein levels of p-PI3K and p-Akt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "confirm", "...
PMC10772747	Under normal conditions, the P53 protein plays a role in maintaining genomic stability and preventing uncontrolled cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "normal", "conditions", "...
PMC9684669	Heatmap: the unsupervised hierarchical clustering showed 177 genes regarding calcium pathway showed the perfect separation in the GSEA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", ":", "the", "unsupervis...
PMC10605143	In addition, in this cell line variant, we noted a greater number of enlarged, flattened and vacuolated cells exhibiting the senescence-associated β-galactosidase (β-gal) activity (Figure 2d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	This study explored the function of p38γ in the treatment of hepatocellular carcinoma with Sora, and showed that p38γ reduced the sensitivity of hepatocellular carcinoma cells to Sora, and pirfenidone could synergistically sensitize Sora to hepatocellular carcinoma by targeting p38γ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661024	Most chemical curative treatments presently administrated for cervical cancer have been cytotoxic to the human body.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "chemical", "curative", "treatments", "presently", ...
PMC10538569	Relative Light Units (RLU) of HIV-1 or 10A1 pseudotypes were determined as previously described (62).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "Light", "Units", "(",...
PMC11794588	We got the appropriate permissions and licenses for the collection of plant specimens from the Administration Department, PMAS-Arid Agriculture University Rawalpindi, and the Department of Agriculture, Government of Punjab, Pakistan.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	All experiments were performed a minimum of 3 times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "performed", "a", "minimum", "of", "3", "times", "." ] } ]
PMC10079526	U2OS cells cultured on glass cover slips were treated with 1 µM 5-Aza-2’ and/or 1 µM TAK981 or DMSO 0.1% as control for 4 or 20 h. Slides were stained with DNMT1 and γH2Ax antibodies.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11143482	The statistical tests are denoted in figure legends.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "tests", "are", "denoted", "in", "figure", "legends", "." ] } ]
PMC6684588	Muscle tissues were analyzed as described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Muscle", "tissues", "were", "analyzed", "as", "described", "." ] } ]
PMC11317131	Detection of secreted vWF in culture media by ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "secreted", "vWF", "in", "culture", "media", "by", "ELISA", "." ] } ]
PMC11453018	Results are presented as relative expression to B2M (n=6) siRNA-mediated knockdown of P300/CBP unveils a pivotal role in ES.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "a...
PMC8806312	GO analysis shows the biological processes and molecular functions involved in DIRGs. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "analysis", "shows", "the", "biological", "processes", "and", "molecul...
PMC11798926	Ultrastructural analysis of hippocampal synapses in mice lacking SynDIG1 showed a decrease in the number of synapses with a mature phenotype (Chenaux et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	Similar to U266, there are a number of DHSs at the CCND1 promoter and within the gene body which are not present in the GM12878 cell line.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLin...
PMC11604768	Dose response curves were generated using GraphPad Prism 9.5.0 using three or four parameter models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dose", "response", "curves", "were", "generated", "using", ...
PMC9587866	The predicted active amino acids are ASP309, ASP311, GLU312, HIS318, THR483, LYS515, ASP537, GLY538, ARG539, and ASP540.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7452526	The high cytotoxicity of CN–Ag at low concentrations open new prospects for the development of novel therapeutic approaches against human colon cancer Caco-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ],...
PMC8041314	Generally, the IC50 values correlated with the values of the calcein AM (ABCB1 and ABCC1) and pheophorbide A (ABCG2) assays (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	The inset shows the fluorescence spectra of the oligothiophene derivative (green line) and M13EGFR(TNP) (red line).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inset", "s...
PMC9688728	Considering metabolomics variability on a relatively long-term basis, careful experimentation with particular attention to control samples is required to ensure reproducibility and relevance of the research results when testing both fundamentally and practically significant hypotheses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	In the absence of viruses, the proportions of GFP+ cells in the mixed populations were relatively stable (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC10237474	The gel was visualized by stain-free imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gel", "was", "visualized", "by", "stain-free", "imaging", "." ] } ]
PMC6889484	Indicated below the vector are the protein products that are expected following viral infection, direct repeat deletion during reverse transcription, translation, and P2A cleavage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765678	These events (NO formation and inhibition of GPX4) eventually lead to cellular accumulation of NO, ROS, and lipid-ROS, ultimately causing ferroptotic cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	Dulbecco’s modified eagle medium/nutrient mixture F12 (DMEM/F-12, 31330038), horse serum (16050122), Dulbecco phosphate buffered saline (DPBS) with calcium and magnesium, fetal bovine serum (FBS), trypsin-EDTA, and antibiotic–antimycotic (anti-anti, 100×) (15240062) were purchased from Thermo Fisher Scientific (Waltham...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10440586	The hypoxia score of single-cell dataset demonstrated in Fig. 2 was measured by gene set variation analysis (GSVA) performed by “GSVA” R package .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10506676	Our understanding of cancer and its molecular underpinnings can be improved by identifying host-virus interactions, which can also help us in the discovery of prognostic indicators, novel antiviral therapies, and therapeutic interventions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	Suzuki–Miyaura coupling of 2-arylbenzofuran iodide S174 with diene borate S14 followed by an additional acetyl reprotection allowed the formation of acetyl-protected precursor S175 in excellent yield.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Death rate was 7.89% (6 patients of which 3 received FCR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Death", "rate", "was", "7.89", "%", "(", "6", "patients", ...
PMC11781181	Besides, plasma exosomes derived from patients with SJS/TEN exhibited elevated levels of cellular oxidized polyunsaturated fatty acids (PUFAs) and phospholipids phosphatidylethanolamine (PE), the key phospholipids that drive cells towards ferroptotic death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	Such heterogeneity can be modulated by various factors, including interactions with ECM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "heterogeneity", "can", "be", "modulated", "by", "various", "factors...
PMC11588085	Log2 Fold Change of XIST in OVCAR3-KRAB sgCtl-Hypoxia vs. sgCtl-Normoxia, sgXIST7-hypoxia vs. sgXIST7-normoxia, and sgXIST9-hypoxia vs. sgXIST-normoxia after 24 h in hypoxia chamber compared to sgCtl, sgXIST7, and sgXIST9 samples in normoxia respectively assessed by RNA-seq. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9812014	DENV has an 11-kb positive-sense RNA-genome that encodes structural proteins such as capsid (C), envelope (E), and membrane precursor (prM), as well as several nonstructural proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Our study corroborates the very favourable outcomes of localized DLBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "Our", "study", "corroborates"...
PMC9509578	Therefore, they could not be established as potent P-gp inhibitors or successful contenders to reverse chemoresistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "they", "could", "not", "b...
PMC10968586	Treatment of human hepatoma HepG2 cells with 50–200 μM HT determined an increase in intracellular ionized calcium levels ([Ca]i) with the contribution of both Ca influxes and mobilization of endoplasmic reticulum depots.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In this retrospective observational trial, It has been evaluated efficacy and tolerance of pomalidomide plus dexamethasone (PD) as salvage regimen in heavily pretreated patients with relapsed and refractory MM (rrMM), whose prognosis is particularly severe.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8143558	Deinbolia oblongifolia (E. Mey.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Deinbolia", "oblongifolia", "(", "E.", "Mey", "." ] } ]
PMC9429973	T. Makarik, K. Sabirov, E. Kitsenko, S. Treglazova, E. Stepanova, I. Fevraleva, S. Kulikov, A. Sudarikov Department of Molecular Hematology; Surgery department, National Research Center for Hematology; National Research Center for Surgery; Biostatistics, National Research Center for Hematology, Moscow, Russia Backgroun...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	It is important to know whether the cell surface anchoring and expression of GPI-scFvs interfere with the expression of HIV receptor and coreceptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC8316344	GSH concentration was calibrated by subtracting the blank value from all readings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSH", "concentration", "was", "calibrated", "by", "subtracting", "the", "blank", ...
PMC11537649	MicroRNA is a type of single-stranded small molecule noncoding RNA that can bind to the 3’-UTR region of mRNA to promote degradation of mRNA or inhibit mRNA translation and regulate target gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10606998	When irradiated with a proton beam at the Bragg peak, no statistically significant difference was observed in the viability of the A-172 and Gl-Tr cell lines cultivated in the presence of nanoparticles and without them (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC9822769	Total RNA was extracted using the guanidinium thiocyanate method .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "extracted", "using", "the", "guanidinium", "thiocyanate", "method", "." ] } ]
PMC9429973	GTA002 is infused after a conditioning regimen of cyclophosphamide (Cy) and fludarabine (Flu) from day -5 to -3 at 300 and 30 mg/m, respectively, with no subsequent planned antileukemic treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: The aim of our study is to assess the impact of early bone morrow blast (BMB) clearance in prediction of complete remission and relapse risk in acute myeloid leukemia Methods: We conducted a retrospective study including patients with AML treated with standard induction chemotherapy (3 days of idarubicine 12mg/m ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	Values correspond to the average plus standard deviation of two different experiments (four samples each) determined by RT-qPCR and expressed relative to PD (P3G4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11522251	Lo et al.’s study showed that inhibition of STAT3 enhances the efficacy of anti-EGFR drugs, which is consistent with our finding that HOXB8 knockdown improves cellular drug sensitivity by down-regulating p-STAT3 expression, further confirming that STAT3 plays a critical role in drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	The A549 (CCL28 overexpression or CCL28 knock-out) tumor model followed the same procedure.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "A549", "(", "CCL28", "overexpression", "or", ...
PMC9429973	Results: Overall intraobserver concordance was comparable for method A (concordance correlation coefficient (CCC)=0.840) and method B (CCC=0.733).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":...
PMC11594806	Adenosine (ADO) reduces the activity of CD4+ and CD8+ T cells, natural killer cells, and dendritic cells, while enhancing the suppressive functions of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median DFS was significantly decreased in null genotype of GSTM1 (9.5 (null) vs 18 months (non-null); p=0.028).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11411131	The Luc-491Sec construct contained the luciferase gene with a Sec substitution for 491Cys.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Luc-491Sec", "construct", "contained", "the", "luciferase", "gene", ...
PMC10854447	H NMR (400 MHz, δ ppm DMSO-d6): 8.80 (s, 1H, triazole-CH), 8.00 (d, J = 8.5 Hz, 2H, Ar–H), 7.89 (d, J = 7.4 Hz, 2H, Ar–H), 7.63 (d, J = 8.5 Hz, 2H, Ar–H), 7.47 (t, J = 7.6 Hz, 2H, Ar–H), 7.36 (t, J = 7.3 Hz, 1H, Ar–H), 6.29 (s, 2H, N–CH2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11281366	Similarly, miRNA-25, a miRNA that we recently found to target peroxisomes components , as well as the E3 ubiquitin ligase MARCH1 , is similarly increased in infected CD4 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	A large ovarian cancer research study found that 2839 SNPs in 138 nuclear encoding genes, 128 SNPs in 22 mitochondrial DNA sections, as well as 2839 SNPs in 138 nuclear encoding genes, have been associated with ovarian cancer susceptibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	The (ζ) of all formulations was between −32.50 and −27.9 mV. In general, zeta potential (ζ) values of ±30 mV were observed to prevent nanovesicles from aggregation and reduce electrostatic repulsion between nanophytosomes, which might contribute to the creation of large aggregates of nanophytosome vesicles .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	In addition, we compared the dead cell ratios of DMSO and different concentrations of CCCP treated groups by typan blue staining, and found that none of the dead cell ratios were significantly increased below 50 μM(results not shown), and these results suggested that CCCP was not significantly toxic to DEF cells below ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11413393	Also notable among the enriched pathways were those related to DNA damage repair (DDR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", "notable", "among", "the", "enriched", "pathway...
PMC11591794	Nine different concentrations were used, ranging from 10 to 1000 µM GA and 10–1000 nM DOX applied to HeLa and HaCat cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], ...
PMC11594074	Targeting epigenetics is a new strategy to treat cancer and develop novel epigenetic drugs with anti-tumor activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeting", "epigenetics", "is", "a", "new", ...
PMC9429973	The median age was 71 with therapy-related MDS (t-MDS) in 37%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "was", "71", "with", "therapy-related", "...
PMC11612626	Previously, we had demonstrated that treatment of multiple myeloma cells with HDAC6 inhibitors promoted proteasomal ChT-like activity (30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previously", ",", ...
PMC11367146	In animal models, injury-induced cartilage lesions were alleviated by the knockdown of NF- κβ p65 in the knee joints .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "animal", "models", ...
PMC11763126	After rinsing with PBS, secondary antibodies were applied for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "rinsing", "with", "PBS", ",", "secondary", "antibo...
PMC11740207	The key molecular signaling pathways for MsPCs include BMP, which is essential for the differentiation into osteocytes and chondrocytes; Wnt/β-catenin, which regulates cell proliferation and differentiation; NOTCH, which is important for SD and differentiation, particularly towards muscle cell formation; the phosphatid...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Treatment of A204 (a PDGFR amplified rhabdomyosarcoma cell line) with the ligand FGF activated pFRS2 and pERK, inducing resistance to sunitinib.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC9429973	Aims: To report the long-term efficacy, safety, pharmacokinetic (PK) and pharmacodynamic (PD) outcomes in pts with PNH treated with crovalimab in the open-label extension (OLE) period of the COMPOSER trial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	The structural proteins will proceed in the exocytic pathway (14), until the end of E1-E2 heterodimers is mature (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10387886	Lim et al. showed that DUSP7 and 8 are subject to methylation-dependent silencing in epithelial ovarian cancer and can be used as clinical markers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Within 2 weeks of initiating CC-99282, peripheral T-cell subsets showed a significant shift toward a more activated phenotype (P<0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "2"...
PMC11640247	A glass micropipette was used to inject 1 µL of plasmid solution into the lateral ventricle of embryos at embryonic day 14 (E14).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11459296	While the model shows promise for studying immunotherapies and tumor-immune system interactions further research should expand to include a broader range of epithelial cancer types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11066331	2 Expression of TUSC3 was downregulated by shRNA transduced into the SKOV3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "2", "Expression", "of", "TUSC3", "was", "downregulated", "by", "sh...
PMC10243817	MEX3B is a canonical KH-domain RBP and usually binds to the 3′ UTR or 5′ UTR of targeted mRNA (46).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MEX3B", "is"...
PMC11643491	While some drugs may lose activity under high temperatures, such as diphenhydramine, midazolam, and fentanyl, certain drugs remain stable in extreme temperatures and are compatible with processes requiring heat, such as morphine and ondansetron .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	For therapeutic applications in cells without a pre-inserted att site, PE is an attractive tool for delivering the att site to a desired locus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9436459	The key features of this approach included the use of Baker-Venkataraman rearrangement, alkylation of β-diketone, intramolecular cyclization, and Suzuki–Miyaura coupling to achieve the unstable dehydroprenylflavone diene .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589	Microsomal glutathione S-transferase 1 (MGST1) is an enzyme located on the cell membrane that facilitates the transfer of glutathione and performs glutathione peroxidase activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11411004	Subsequently, we applied qRT-PCR to determine the relative levels of antibody light chain (LC) and heavy chain (HC) mRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7757104	In addition, tOPN knockdown sensitized cells to drug exposure (15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "tOPN", "knockdown", "sensitized", "cells", "to", ...
PMC10174970	The correlation based on general gene-profile was evaluated according to a previously reported algorithm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "correlation", "based", "on", "general", "gene-profile", "was", ...
PMC9917080	In response to infection or inflammation, astrocyte reactivation occurs, leading to the release of pro-inflammatory cytokines, changes in the morphology of astrocytes and their migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	Following treatment with TAK981 (1 µM) and/or 5-Aza-2’ (1 µM), or control DMSO (0.01%), cells were fixed with 4% paraformaldehyde for 15 min, followed by washing 3 times with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11371627

Electrophysiological investigations revealed axonal polyneuropathy with motor and sensory involvement, fasciculations and pathological spontaneous activity but formally normal motor unit action potentials (MUPs) in left vastus muscle, left tibial anterior muscle and left gastrocnemius muscle.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11543935

Upscaling the hydrogel would further enhance its image quality and the size also limits potential MR techniques like the thermometry shown in Fig. 3A.

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PMC7039683

Both of these human non-coding elements have periderm enhancer activity in zebrafish embryos.

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PMC11509224

Pseudoaxinella is another genus of sponge that has produced only one diterpene.

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PMC11739504

Data were collected from three independent experiments.

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PMC9268620

The treatments were carried out in 60 mm petri dishes (Nunc) with a working volume of 5 mL. Briefly, cells with a density of 1 × 10 cells/mL were treated with 30, 10, 3, and 1 µg/mL of nordamnacanthal and damnacanthal.

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PMC11129910

RAO-1 is a human mammary epithelial cell (HMEC) line obtained from healthy individuals undergoing reduction mammoplasty and was immortalized by transduction with the catalytic subunit of telomerase (hTERT) after passage through stasis.

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PMC11518702

These include N-terminal myristoylation and palmitoylation sites; four modulated central phospho-tyrosine (pY) motifs (with BCR-activated SYK as an indicated phosphorylating kinase); a validated DDpY107ENV binding site for GRB2 docking; a validated C-terminal PDZ-RhoGEF binding motif (PBM); and an H91 site demonstrated...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11470999

First, we analyzed the expression levels of CIP2A in normal nevus samples and melanoma in The Cancer Genome Atlas (TCGA) and found that its mRNA was upregulated in melanoma (Figure 4A).

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PMC5574817

HEK293 cells were suspended in an appropriate volume of ice-cold Opti-MEM® (Gibco, USA) electroporation buffer.

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PMC7452526

The mixture was kept under stirring at room temperature for almost half an hour to ensure the homogeneous reduction process.

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PMC11267830

Our research also revealed that in HUT78 and 6T-cem cells, the mRNA expression of DCAF15 is similar to that in other T-ALL cells, and RBM39 can be significantly degraded after treatment with indisulam.

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PMC11763111

Ficoll-Paque (LDS1075) was used to layer peripheral blood, and density gradient centrifugation was used to separate peripheral blood mononuclear cells (PBMCs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11352311

To confirm this, we used Western blotting to examine the changes in the protein levels of p-PI3K and p-Akt.

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PMC10772747

Under normal conditions, the P53 protein plays a role in maintaining genomic stability and preventing uncontrolled cell proliferation.

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PMC9684669

Heatmap: the unsupervised hierarchical clustering showed 177 genes regarding calcium pathway showed the perfect separation in the GSEA.

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PMC10605143

In addition, in this cell line variant, we noted a greater number of enlarged, flattened and vacuolated cells exhibiting the senescence-associated β-galactosidase (β-gal) activity (Figure 2d).

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PMC11772449

This study explored the function of p38γ in the treatment of hepatocellular carcinoma with Sora, and showed that p38γ reduced the sensitivity of hepatocellular carcinoma cells to Sora, and pirfenidone could synergistically sensitize Sora to hepatocellular carcinoma by targeting p38γ.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11661024

Most chemical curative treatments presently administrated for cervical cancer have been cytotoxic to the human body.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "chemical", "curative", "treatments", "presently", ...

PMC10538569

Relative Light Units (RLU) of HIV-1 or 10A1 pseudotypes were determined as previously described (62).

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PMC11794588

We got the appropriate permissions and licenses for the collection of plant specimens from the Administration Department, PMAS-Arid Agriculture University Rawalpindi, and the Department of Agriculture, Government of Punjab, Pakistan.

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PMC10810426

All experiments were performed a minimum of 3 times.

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PMC10079526

U2OS cells cultured on glass cover slips were treated with 1 µM 5-Aza-2’ and/or 1 µM TAK981 or DMSO 0.1% as control for 4 or 20 h. Slides were stained with DNMT1 and γH2Ax antibodies.

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PMC11143482

The statistical tests are denoted in figure legends.

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PMC6684588

Muscle tissues were analyzed as described.

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PMC11317131

Detection of secreted vWF in culture media by ELISA.

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PMC11453018

Results are presented as relative expression to B2M (n=6) siRNA-mediated knockdown of P300/CBP unveils a pivotal role in ES.

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PMC8806312

GO analysis shows the biological processes and molecular functions involved in DIRGs. (

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PMC11798926

Ultrastructural analysis of hippocampal synapses in mice lacking SynDIG1 showed a decrease in the number of synapses with a mature phenotype (Chenaux et al., 2016).

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PMC9341513

Similar to U266, there are a number of DHSs at the CCND1 promoter and within the gene body which are not present in the GM12878 cell line.

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PMC11604768

Dose response curves were generated using GraphPad Prism 9.5.0 using three or four parameter models.

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PMC9587866

The predicted active amino acids are ASP309, ASP311, GLU312, HIS318, THR483, LYS515, ASP537, GLY538, ARG539, and ASP540.

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PMC7452526

The high cytotoxicity of CN–Ag at low concentrations open new prospects for the development of novel therapeutic approaches against human colon cancer Caco-2.

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PMC8041314

Generally, the IC50 values correlated with the values of the calcein AM (ABCB1 and ABCC1) and pheophorbide A (ABCG2) assays (Table 2).

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PMC11707577

The inset shows the fluorescence spectra of the oligothiophene derivative (green line) and M13EGFR(TNP) (red line).

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PMC9688728

Considering metabolomics variability on a relatively long-term basis, careful experimentation with particular attention to control samples is required to ensure reproducibility and relevance of the research results when testing both fundamentally and practically significant hypotheses.

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PMC7812570

In the absence of viruses, the proportions of GFP+ cells in the mixed populations were relatively stable (data not shown).

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PMC10237474

The gel was visualized by stain-free imaging.

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PMC6889484

Indicated below the vector are the protein products that are expected following viral infection, direct repeat deletion during reverse transcription, translation, and P2A cleavage.

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PMC11765678

These events (NO formation and inhibition of GPX4) eventually lead to cellular accumulation of NO, ROS, and lipid-ROS, ultimately causing ferroptotic cell death.

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PMC11546117

Dulbecco’s modified eagle medium/nutrient mixture F12 (DMEM/F-12, 31330038), horse serum (16050122), Dulbecco phosphate buffered saline (DPBS) with calcium and magnesium, fetal bovine serum (FBS), trypsin-EDTA, and antibiotic–antimycotic (anti-anti, 100×) (15240062) were purchased from Thermo Fisher Scientific (Waltham...

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PMC10440586

The hypoxia score of single-cell dataset demonstrated in Fig. 2 was measured by gene set variation analysis (GSVA) performed by “GSVA” R package .

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PMC10506676

Our understanding of cancer and its molecular underpinnings can be improved by identifying host-virus interactions, which can also help us in the discovery of prognostic indicators, novel antiviral therapies, and therapeutic interventions.

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PMC9436459

Suzuki–Miyaura coupling of 2-arylbenzofuran iodide S174 with diene borate S14 followed by an additional acetyl reprotection allowed the formation of acetyl-protected precursor S175 in excellent yield.

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PMC9429973

Death rate was 7.89% (6 patients of which 3 received FCR).

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PMC11781181

Besides, plasma exosomes derived from patients with SJS/TEN exhibited elevated levels of cellular oxidized polyunsaturated fatty acids (PUFAs) and phospholipids phosphatidylethanolamine (PE), the key phospholipids that drive cells towards ferroptotic death.

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PMC10170482

Such heterogeneity can be modulated by various factors, including interactions with ECM.

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PMC11588085

Log2 Fold Change of XIST in OVCAR3-KRAB sgCtl-Hypoxia vs. sgCtl-Normoxia, sgXIST7-hypoxia vs. sgXIST7-normoxia, and sgXIST9-hypoxia vs. sgXIST-normoxia after 24 h in hypoxia chamber compared to sgCtl, sgXIST7, and sgXIST9 samples in normoxia respectively assessed by RNA-seq. (

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PMC9812014

DENV has an 11-kb positive-sense RNA-genome that encodes structural proteins such as capsid (C), envelope (E), and membrane precursor (prM), as well as several nonstructural proteins .

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PMC9429973

Image: Summary/Conclusion: Our study corroborates the very favourable outcomes of localized DLBCL.

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PMC9509578

Therefore, they could not be established as potent P-gp inhibitors or successful contenders to reverse chemoresistance .

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PMC10968586

Treatment of human hepatoma HepG2 cells with 50–200 μM HT determined an increase in intracellular ionized calcium levels ([Ca]i) with the contribution of both Ca influxes and mobilization of endoplasmic reticulum depots.

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PMC9429973

In this retrospective observational trial, It has been evaluated efficacy and tolerance of pomalidomide plus dexamethasone (PD) as salvage regimen in heavily pretreated patients with relapsed and refractory MM (rrMM), whose prognosis is particularly severe.

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PMC8143558

Deinbolia oblongifolia (E. Mey.

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PMC9429973

T. Makarik, K. Sabirov, E. Kitsenko, S. Treglazova, E. Stepanova, I. Fevraleva, S. Kulikov, A. Sudarikov Department of Molecular Hematology; Surgery department, National Research Center for Hematology; National Research Center for Surgery; Biostatistics, National Research Center for Hematology, Moscow, Russia Backgroun...

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PMC8735881

It is important to know whether the cell surface anchoring and expression of GPI-scFvs interfere with the expression of HIV receptor and coreceptors.

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PMC8316344

GSH concentration was calibrated by subtracting the blank value from all readings.

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PMC11537649

MicroRNA is a type of single-stranded small molecule noncoding RNA that can bind to the 3’-UTR region of mRNA to promote degradation of mRNA or inhibit mRNA translation and regulate target gene expression.

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PMC10606998

When irradiated with a proton beam at the Bragg peak, no statistically significant difference was observed in the viability of the A-172 and Gl-Tr cell lines cultivated in the presence of nanoparticles and without them (Figure 4).

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PMC9822769

Total RNA was extracted using the guanidinium thiocyanate method .

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PMC9429973

GTA002 is infused after a conditioning regimen of cyclophosphamide (Cy) and fludarabine (Flu) from day -5 to -3 at 300 and 30 mg/m, respectively, with no subsequent planned antileukemic treatment.

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PMC9429973

Aims: The aim of our study is to assess the impact of early bone morrow blast (BMB) clearance in prediction of complete remission and relapse risk in acute myeloid leukemia Methods: We conducted a retrospective study including patients with AML treated with standard induction chemotherapy (3 days of idarubicine 12mg/m ...

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PMC10114490

Values correspond to the average plus standard deviation of two different experiments (four samples each) determined by RT-qPCR and expressed relative to PD (P3G4).

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PMC11522251

Lo et al.’s study showed that inhibition of STAT3 enhances the efficacy of anti-EGFR drugs, which is consistent with our finding that HOXB8 knockdown improves cellular drug sensitivity by down-regulating p-STAT3 expression, further confirming that STAT3 plays a critical role in drug resistance.

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PMC11285179

The A549 (CCL28 overexpression or CCL28 knock-out) tumor model followed the same procedure.

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PMC9429973

Results: Overall intraobserver concordance was comparable for method A (concordance correlation coefficient (CCC)=0.840) and method B (CCC=0.733).

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PMC11594806

Adenosine (ADO) reduces the activity of CD4+ and CD8+ T cells, natural killer cells, and dendritic cells, while enhancing the suppressive functions of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs).

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PMC9429973

Median DFS was significantly decreased in null genotype of GSTM1 (9.5 (null) vs 18 months (non-null); p=0.028).

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PMC11411131

The Luc-491Sec construct contained the luciferase gene with a Sec substitution for 491Cys.

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PMC10854447

H NMR (400 MHz, δ ppm DMSO-d6): 8.80 (s, 1H, triazole-CH), 8.00 (d, J = 8.5 Hz, 2H, Ar–H), 7.89 (d, J = 7.4 Hz, 2H, Ar–H), 7.63 (d, J = 8.5 Hz, 2H, Ar–H), 7.47 (t, J = 7.6 Hz, 2H, Ar–H), 7.36 (t, J = 7.3 Hz, 1H, Ar–H), 6.29 (s, 2H, N–CH2).

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PMC11281366

Similarly, miRNA-25, a miRNA that we recently found to target peroxisomes components , as well as the E3 ubiquitin ligase MARCH1 , is similarly increased in infected CD4 T cells.

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PMC11743316

A large ovarian cancer research study found that 2839 SNPs in 138 nuclear encoding genes, 128 SNPs in 22 mitochondrial DNA sections, as well as 2839 SNPs in 138 nuclear encoding genes, have been associated with ovarian cancer susceptibility.

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PMC11190538

The (ζ) of all formulations was between −32.50 and −27.9 mV. In general, zeta potential (ζ) values of ±30 mV were observed to prevent nanovesicles from aggregation and reduce electrostatic repulsion between nanophytosomes, which might contribute to the creation of large aggregates of nanophytosome vesicles .

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PMC10891340

In addition, we compared the dead cell ratios of DMSO and different concentrations of CCCP treated groups by typan blue staining, and found that none of the dead cell ratios were significantly increased below 50 μM(results not shown), and these results suggested that CCCP was not significantly toxic to DEF cells below ...

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PMC11413393

Also notable among the enriched pathways were those related to DNA damage repair (DDR).

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PMC11591794

Nine different concentrations were used, ranging from 10 to 1000 µM GA and 10–1000 nM DOX applied to HeLa and HaCat cell lines.

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PMC11594074

Targeting epigenetics is a new strategy to treat cancer and develop novel epigenetic drugs with anti-tumor activity.

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PMC9429973

The median age was 71 with therapy-related MDS (t-MDS) in 37%.

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PMC11612626

Previously, we had demonstrated that treatment of multiple myeloma cells with HDAC6 inhibitors promoted proteasomal ChT-like activity (30).

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PMC11367146

In animal models, injury-induced cartilage lesions were alleviated by the knockdown of NF- κβ p65 in the knee joints .

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PMC11763126

After rinsing with PBS, secondary antibodies were applied for 1 h at room temperature.

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PMC11740207

The key molecular signaling pathways for MsPCs include BMP, which is essential for the differentiation into osteocytes and chondrocytes; Wnt/β-catenin, which regulates cell proliferation and differentiation; NOTCH, which is important for SD and differentiation, particularly towards muscle cell formation; the phosphatid...

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PMC4270159

Treatment of A204 (a PDGFR amplified rhabdomyosarcoma cell line) with the ligand FGF activated pFRS2 and pERK, inducing resistance to sunitinib.

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PMC9429973

Aims: To report the long-term efficacy, safety, pharmacokinetic (PK) and pharmacodynamic (PD) outcomes in pts with PNH treated with crovalimab in the open-label extension (OLE) period of the COMPOSER trial.

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PMC8524093

The structural proteins will proceed in the exocytic pathway (14), until the end of E1-E2 heterodimers is mature (15).

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PMC10387886

Lim et al. showed that DUSP7 and 8 are subject to methylation-dependent silencing in epithelial ovarian cancer and can be used as clinical markers .

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PMC9429973

Within 2 weeks of initiating CC-99282, peripheral T-cell subsets showed a significant shift toward a more activated phenotype (P<0.05).

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PMC11640247

A glass micropipette was used to inject 1 µL of plasmid solution into the lateral ventricle of embryos at embryonic day 14 (E14).

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PMC11459296

While the model shows promise for studying immunotherapies and tumor-immune system interactions further research should expand to include a broader range of epithelial cancer types.

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PMC11066331

2 Expression of TUSC3 was downregulated by shRNA transduced into the SKOV3 cells.

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PMC10243817

MEX3B is a canonical KH-domain RBP and usually binds to the 3′ UTR or 5′ UTR of targeted mRNA (46).

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PMC11643491

While some drugs may lose activity under high temperatures, such as diphenhydramine, midazolam, and fentanyl, certain drugs remain stable in extreme temperatures and are compatible with processes requiring heat, such as morphine and ondansetron .

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PMC11317131

For therapeutic applications in cells without a pre-inserted att site, PE is an attractive tool for delivering the att site to a desired locus.

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PMC9436459

The key features of this approach included the use of Baker-Venkataraman rearrangement, alkylation of β-diketone, intramolecular cyclization, and Suzuki–Miyaura coupling to achieve the unstable dehydroprenylflavone diene .

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PMC11536589

Microsomal glutathione S-transferase 1 (MGST1) is an enzyme located on the cell membrane that facilitates the transfer of glutathione and performs glutathione peroxidase activities.

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PMC11411004

Subsequently, we applied qRT-PCR to determine the relative levels of antibody light chain (LC) and heavy chain (HC) mRNA.

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PMC7757104

In addition, tOPN knockdown sensitized cells to drug exposure (15).

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PMC10174970

The correlation based on general gene-profile was evaluated according to a previously reported algorithm.

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PMC9917080

In response to infection or inflammation, astrocyte reactivation occurs, leading to the release of pro-inflammatory cytokines, changes in the morphology of astrocytes and their migration .

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PMC10079526

Following treatment with TAK981 (1 µM) and/or 5-Aza-2’ (1 µM), or control DMSO (0.01%), cells were fixed with 4% paraformaldehyde for 15 min, followed by washing 3 times with PBS.

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