OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	One patient underwent an allogeneic SCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "underwent", "an", "allogeneic", "SCT", "." ] } ]
PMC10728200	The GSH/GSSG ratio (Fig. 5C) and the expression of GPX4 (Fig. 5D, E) in RSL3 combined with the IM group were lower than those in IM or RSL3 group alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	Moreover, abnormalities in mitochondrial dynamics have been associated with metabolic abnormalities in cancer progression, as well as proteins responsible for chemosensitivity and chemotherapy resistance in OC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9926039	Furthermore, comparisons between multiple data from different treatment groups were conducted using the least significant difference (post hoc) test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ...
PMC9429973	Appropriate combination therapy is important after acquiring the information of enzymes and susceptibility to CAZ-AVI in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Appropriate", "combination", "therapy", "is", "im...
PMC11792090	Percentage of CD47CAR cells in UCAR-T and SAP UCAR-T cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentage", "of", "CD47CAR", "cells", "in", "UCAR-T", "and", "SAP", "UCAR-T", "cells...
PMC10926885	The primer sequences used are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sequences", "used", "are", "shown", "in", "Table", "1", "." ] } ]
PMC9429973	Median number of M retreatment cycles received was 8.0 (range, 2–13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "number", "of", "M", "retreatment", "cycles", "received", ...
PMC11772585	H The mRNA levels of ATF4 in cells transfected with WT METTL1 or Mut METTL1 were assessed by qRT-PCR (n = 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11448304	Liao et al. discovered that Khib modification on NAT10 molecule can enhance its interaction with deubiquitinase and subsequently promote cancer metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Liao", "et", "al....
PMC11694066	E, Dose–response survival curves of JN1 cells exposed to PARPi talazoparib (F) or olaparib (G), and ATRi M4344 (H) or AZD6738 (I) for 7 days in the presence or absence of siRNA-mediated silencing of EWS–WT1 and/or RNase H1 overexpression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267036	Collectively, these results suggest that DHM can inhibit MM tumor growth and EMT in vivo via STAT1/RIG-I activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "these", "res...
PMC10758402	RevertAid First Strand cDNA Synthesis Kit was used to convert 1 ug of RNA to cDNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RevertAid", "First", "Strand", "cDNA", "Synthesis", "K...
PMC11033180	Cell-attached patch-clamp recordings were conducted to observe the spontaneous firing activity of individual enteric neurons while maintaining the cytoplasmic contents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell-attached", "patch-clamp", ...
PMC9429973	High resolution MFC improved the detection of BM infiltration, potentially affecting IPI score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "resolution", "MFC", "improved", "the", "detection", "of", ...
PMC11785489	However, a causal pathway that begins with V(D)J recombination and ends with the T cell state likely includes several important biological mediators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC7840816	Our study showed that SOX9 was overexpressed in PTC tissues and cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "showed", "that", "SOX9", "was", "overexpressed", "in", ...
PMC10547921	Pettit et al. designed auristatin analogs 13–15 modified with C-terminal aromatic phosphate and quinoline, with an IC50 of 0.81, 0.19 and 6.35 nmol/L on McF-7 cells, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11721587	Mammalian cells were transfected with PolyJet in vitro DNA transfection kit (SignaGen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mammalian", "cells", "were", "transfected", "with", "PolyJet", "in", ...
PMC9429973	Classically, WHIM syndrome pathogenesis is causally linked to a variety of heterozygous gain-of-function mutations in the C-terminus of chemokine receptor CXCR4, a master regulator of immune cell trafficking and homeostasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	Tumor-infiltrating immune cell subsets were reported to be associated with either better or worse prognosis in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor-infiltrating", "immune", "cell", "subsets", ...
PMC11049294	The peak fluorescent intensity could be detected after 5 h of incubation (2776 ± 80.79 MFI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "peak", "fluorescent", "intensity", ...
PMC11628904	We found that burn depth was unchanged 1 dpb regardless of treatment, highlighting that our burn wound paradigm was able to produce wounds of consistent depth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721096	To date, various affinity-based methods have been developed for this purpose, including ligand fishing , affinity ultrafiltration , and cell membrane affinity chromatography , among which ligand fishing based on immobilization of the target protein has drawn increasing attention due to its high specificity and ease of ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3681794	6–8 hours after transfection cells were incubated in hypoxia until drug exposure 32 hours after transfection (after 24 hours in hypoxia).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6–8", ...
PMC11502443	To allow comparison, data were normalized to GIP(1-42) at the WT receptor for each signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "allow", "comparison", ...
PMC11773391	Our data showed that TMZ stimulation could activate the ERK signalling pathway in A375 cells, which in turn increased the promoter transcriptional activity of MGMT, indicating that after TMZ treatment, intracellular MGMT depletion increased and reserves decreased, but MGMT transcription could be enhanced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9688728	The most (86%) metabolites are characterized by F-ratios ranging from 20 to 180.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "(", "86", "%", ")", "metabolites"...
PMC11269792	Small interfering RNA targeting circAPP and CDV3, small interfering RNA negative control (si-circAPP: 5’-ATGGATGTTTGCGAAACTCATCT-3’, si-CDV3, si-NC), overexpression plasmid targeting circAPP and CDV3 and negative control (pcDNA 3.1-circAPP/CDV3, pcDNA 3.1) were supplied by RiboBio (Guangzhou, China), whereas miR-6838-5...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	Among these, epigallocatechin gallate (EGCG), a major catechin in green tea, has shown the most potent antiproliferative effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among",...
PMC9370419	We assumed that estradiol benzoate represses HBV replication and translation through the inhibition of the HBx protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "assumed", "that", "estradiol", "benzoate", ...
PMC11574029	Furthermore, CCK-8 assay results showed that SPP1 overexpression promoted tumor cell proliferation, but this effect disappeared after treatment with LY294002 (Fig. 4G, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587541	The thermal profile setup for QPCR consisted of the following steps : an initial denaturation at 95 °C for 10-min, 45 cycles of 95° C hold for 15 s, followed by annealing at 60 °C for 30 s, and 72 °C hold for 11 s. Table 1Showing the primer sequence of different genes used during the studyGenePrimer sequenceTelomere_F5...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	Lactic acid accumulation makes the intracellular environment acidic by increasing proton concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactic", "acid", "accumulation", "makes", "the", "intracellular", "environment", "acid...
PMC11791432	At the same time, U87 cells transfected with lentivirus stably interfering with ANXA1 (treatment group) and negative control group U87 cells were implanted into the skull of 6 BALB/c female mice (12 mice in total), and the survival time of mice was followed up to observe, the survival curve is shown in Fig. 7C.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "...
PMC8875242	Some of the tested antivirals can be extensively metabolized by CYP3A4 , resulting in less pronounced ABCB1 inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "of", "the", "tested", "antivir...
PMC11680982	For HER2-low tumor volume on day 21: normal saline vs. medium-dose ET + CDK4/6i + Ner, P = 0.0001; normal saline vs. low-dose ET + CDK4/6i + Ner, P = 0.0017; normal saline vs. ET + CDK4/6i, P = 0.003; ET + CDK4/6i vs. medium-dose ET + CDK4/6i + Ner, P = 0.0021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	AML transformation of SF3B1 mutated MDS patients is determined by the entire genomic landscape indicating RUNX1 as potential driver.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AML", "transformation", "of", "SF...
PMC11634027	For each wing, 35-70 wing hairs were examined and five or six wings were analyzed per genotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "wing", ...
PMC11216402	Because the Mes-like cell lines are epigenomically and transcriptionally similar to fibroblasts, we next sought to verify that they are not simply normal fibroblasts, or possibly CAFs (Sahai et al. 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7053076	Overexpression of ATP-binding cassette (ABC) transporters in many types of cancer is responsible for the reduction of the cellular uptake of various anticancer drugs causing multidrug resistance (MDR), the major obstacle in cancer chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11468365	The DeepChem is an open-source library designed for applying deep learning to problems in chemistry, materials science, and biology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DeepChem", ...
PMC9429973	In the absence of DLT, subsequent dose levels will increase sequentially according to a modified Fibonacci approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "absence", "of", "DLT", ...
PMC10759659	The clinical information of patients included in this study can be found in Supplementary file S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinical", "information", "of", "patients", "in...
PMC9429973	In order to prevent nephrotoxicity, Melphalan is often administrated with hyperhydration (HH) consisting of 4-6 Litres (L) 0.9% saline which has a potential fluid overload risk, mainly in elderly patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11661040	H-J) Western blot analysis confirmed that the overexpression of CGREF1 resulted in an upregulation of Cyclin D expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H-J", ")", "Western", "blot", ...
PMC11742047	These values reflect the importance of each variable in the model both for Y, i.e., its correlation with all observations, and for X (the projection).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11237030	We characterised one clone, named clone 16, that was able to stably express AQP5 h on the plasma membrane and also intracellularly over time by means of immunofluorescence and Western blot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Early on-treatment changes in PB were associated with response to glofitamab: induction of IL-6, IFNγ, IL-10, and TNFα in the 6 hours after the first glofitamab dose was strongest in pts with CR (IL-6, IFNγ, IL-10: 6- to 16-fold induction; TNFα: 1.5-fold induction).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790971	In addition, the ratios of cells with certain and uncertain labels were kept the same among all passages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", ...
PMC11607321	We initially tested 16 multi-omics integration methods (Supplementary Data 6, see Methods), but due to constraints such as the number of omics supported, type of data distribution, and limitations in design and implementation, we were narrowed to three state-of-the-art methods: MOFA, MOVE, and mixOmics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	Unmethylated copies were not targeted for amplification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unmethylated", "copies", "were", "not", "targeted", "for", "amplification", "." ] } ]
PMC10748106	The MEP map provides a perception of the molecular size and the location of electron-rich and -deficient zones on a compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MEP", "map...
PMC9780037	Cyt c nitrations at tyrosines 46 and 48 have impaired the formation of functional apoptosomes and might even promote cyt c degradation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyt", "c", ...
PMC11583690	Based on the DTX loading capacity of 122.25 mg/g for BPMO and 120.33 mg/g for MSN, the DTX weight was calculated to correspond to 1 mg of free DTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476837	These derivatives potentially increase the sensitivity of cancer cells to anticancer drugs such as sorafenib or regorafenib .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "derivatives", "potentially", "increase", ...
PMC9444294	Studies utilizing anti-SS18 antibodies need to account for the concurrent presence of typically large amounts of wild-type SS18, as the fusion oncoprotein retains 410 out of the 418 amino acids present in full-length SS18.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11055510	The down-regulation of circMAN1A2 was the opposite of the up-regulation of circMAN1A2. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "down-regulation", "of", "circMAN1A2", "was", "the", "opposite", "of"...
PMC11705630	Particularly, canonical driver genes of human cancer, such as MYC, can upregulate nucleotide synthesis by directly or indirectly inducing genes in nucleotide synthesis 6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9368503	In addition, we show that the dual PI3K-mTOR inhibitor NVP-BEZ235 (also known as dactolisib) reduces the cell viability of ICR-SS-1 and the two other synovial sarcoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11075223	Prim-O-glucosylcimifugin (7.5 mg/kg, 15 mg/kg, 30 mg/kg) improved brain Cerebral ischemia/reperfusion (I/R) symptoms and neuronal apoptosis according to the number of errors in the step-down test and the neurological deficit score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	This may help explain why UCEC patients with high miR-424 expression had improved survival rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "may", "help", "explain", "why", "UCEC", "patients",...
PMC11257988	This dilemma was broken in 2013 when American chemical biologist Kevan Shokat discovered that when KRASG12C protein is in the inactive GDP-bound state, the switch II domain (SIIP) of its mutated cysteine residue exhibits a pocket structure that can covalently bind to small molecule drugs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170	Conversely, PDGFRA-mutated GISTs are more prone to a benign behavior than those with codon 557/558 deletions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "PDGFRA-mutated", "GISTs", "are...
PMC9429973	Predictors of response 40 (39%) patients achieved complete remission (CR), 20 (19%) CR with incomplete hematological recovery (CRi), resulting in CR/CRi in 60 (58%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	To create bifunctional AS1411‐RhoBAST as a DNA‐RNA conjugate, we ligated the 3′ end of in vitro transcribed RhoBAST with the 5′ end of single‐stranded AS1411 oligonucleotide (Figure S3A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	Plexin A1 was notably found at the periphery of the neuronal cell bodies suggesting a cell surface localization (Figures 2F and 2F′).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11538390	The human induced pluripotent stem cells (iPSCs), UCSFi001-A ([WTC11], Coriell Institute for Medical Research, Catalog no. GM25256), were maintained in mTeSR1 media (StemCell Technologies) on Matrigel (Corning) coated plates and passaged with Accutase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The study of the mean fluorescence intensity (MFI) of MSC markers revealed a significant decrease in MFI of CD274 (PD-L1) in primary patients compared to healthy donors and its absence on the cells of patients in remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	In the same human breast cancer cell lines MDA-MB-453 and SK-BR-3, the mRNA levels of some proliferation-related genes, such as CCND2, CDK2 and Ki67, were significantly up-regulated when stimulated by recombinant FGF18 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11794568	Studies have shown that in a variety of cancer types, mitochondrial biogenesis is activated to increase ATP production to support tumor growth and spread.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11413393	Individual knockdowns indicate PRMT1 as the specific critical dependency for cancer growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Individual", "knockdowns", "indicate", "PRMT1", "as", "the", "specific", "critical", ...
PMC11122631	We also used the tool to predict the oral bioavailability of nine compounds (Figure S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "used", "the", "tool", "to", ...
PMC6267596	We demonstrated that during 4-days of alisertib treatment, DH/DE-DLBCL cells become polyploid (≤4n).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "demonstrated", "that", "during", "4-days", "of",...
PMC6684588	Data are means ± SEM (n = 8–10). **	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SEM", "(", "n", "=", "8–10", ")", ".", ...
PMC10243817	All work was carried out in accordance with the Declaration of Helsinki for experiments involving humans.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "work", "was", "carried", "out", "in", "ac...
PMC9429973	As for the cytogenetic aberrations, did not play an important role in the outcome of pPCL patients other than the presence of del(17p) which could impact OS in the univariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637284	The control experiments that the TAC60 mutants used in our study completely replace the endogenous TAC60 and are fully integrated into the TAC are provided in S6 and S7 Figs, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	Fig. 6Antimicrobial activity of purified azurin against various bacterial strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Antimicrobial", "activity", "of", "purified", "azurin", "against", "various", "bacterial", ...
PMC11310713	In recent years, the field of 3-dimensional (3D) encapsulated cells has gained prominence as a promising approach to treating tissue and organ injuries, offering marked potential for advancing cell-based therapies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The date of the point is in July 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "date", "of", "the", "point", "is", "in", "July", "2021", "." ] } ]
PMC9429973	Pt characteristics are summarized in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pt", "characteristics", "are", "summarized", "in", "Table", "1", "." ] } ]
PMC9118379	Although identified variant peptides pass an FDR of 1%, the results of 11 examinations reveal that the essential FDR criterion requirement is not sufficient to validate identified variant peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Furthermore, TSL exhibits efficacy against lapatinib-resistant breast cancer cells, offering a promising avenue for breast cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "TSL", "exhibi...
PMC11799620	Briefly, 1 ml of the OFAE (varying concentrations) was mixed with 1 ml phosphate buffer (20 mM, pH 7.4) containing ferric chloride (1 mM), EDTA (1 mM), deoxyribose (2.8 mM), 0.1 ml ascorbic acid (1 mM), and 0.5 ml hydrogen peroxide (20 mM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11297139	The size and purity of the eluted proteins were analyzed by SDS–PAGE and Coomassie blue staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "size", "and", "purity", "of", ...
PMC11687167	These experimental results above demonstrated that PCSK9 could regulate the TLR4/NF-κB signaling pathway through TLR4 independent of cellular lipid metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "experimental", "res...
PMC11401358	Due to the high molecular weight of SF, representative polypeptides e.g. (GAGSGA)2 and GAGVGAGY from SF heavy chains were chosen for the mechanistic study of the antioxidant effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Notably, small molecules that could specifically modulate biomolecular condensates have drawn great attention as therapeutics for neurodegenerative diseases and cancers (Richard et al., 2019, Preprint; Wang et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: The RMR was searched for all patients with a diagnosis of WM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "RMR", "was", "searched", "for", "all", ...
PMC10606998	Consequently, at the same absorbed dose, the radiation damage to the cells loaded with nanoparticles will be greater compared to the cells without nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9599726	Imatinib-sensitive (GIST882) and imatinib-resistant (GIST48) cells were treated with class II FIN RSL3, a direct GPX4 inhibitor for 3 h. We first assessed the cell viability.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC8913139	Combined with these results, ROCK1 is considered to be an oncogene in GBM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combined", "with", "these", "results", ",", "ROCK1", "is", "cons...
PMC5925824	Whether these observations reflect a direct effect of PD-L1 blockade on innate immune cells or an indirect effect resulting from T cell activation, they underscore the diverse and to-date not fully appreciated role for PD-L1 blockade to modulate the activity and function of cell types beyond T lymphocytes, and highligh...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11752740	A fraction affected (Fa) of 0.5 represents the effective dose that kills 50% of the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "fraction", "affected", "(", ...
PMC10890307	Understanding metabolic adaptive mechanisms for tumor cell survival may provide promising opportunities to improve traditional cancer therapies, considering that other conditions (lactic acidosis, hypoxia) should be tested when analyzing drug sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Despite the paradigm shift in the treatment landscape, there is still a subset of patients with a worse prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "the", "paradigm",...
PMC11697065	Results are expressed as mean ± standard error of the mean (SEM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "expressed", "as", "mean", "±", "standard", "er...
PMC3813807	The primer sequences used for the RT-PCR amplification are shown in Table I. All primers were synthesized by Sangon Biotech (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9895440	1.5 μl of these aligned crRNA-tracrRNA complexes was then incubated with 15 μl of 40 μM Cas9-NLS protein (Berkeley, QB3) for 30 min at room temperature in the dark and used immediately (referred to as Cas9-RNP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

One patient underwent an allogeneic SCT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "patient", "underwent", "an", "allogeneic", "SCT", "." ] } ]

PMC10728200

The GSH/GSSG ratio (Fig. 5C) and the expression of GPX4 (Fig. 5D, E) in RSL3 combined with the IM group were lower than those in IM or RSL3 group alone.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11743316

Moreover, abnormalities in mitochondrial dynamics have been associated with metabolic abnormalities in cancer progression, as well as proteins responsible for chemosensitivity and chemotherapy resistance in OC .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9926039

Furthermore, comparisons between multiple data from different treatment groups were conducted using the least significant difference (post hoc) test.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ...

PMC9429973

Appropriate combination therapy is important after acquiring the information of enzymes and susceptibility to CAZ-AVI in vitro.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Appropriate", "combination", "therapy", "is", "im...

PMC11792090

Percentage of CD47CAR cells in UCAR-T and SAP UCAR-T cells. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentage", "of", "CD47CAR", "cells", "in", "UCAR-T", "and", "SAP", "UCAR-T", "cells...

PMC10926885

The primer sequences used are shown in Table 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sequences", "used", "are", "shown", "in", "Table", "1", "." ] } ]

PMC9429973

Median number of M retreatment cycles received was 8.0 (range, 2–13).

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PMC11772585

H The mRNA levels of ATF4 in cells transfected with WT METTL1 or Mut METTL1 were assessed by qRT-PCR (n = 6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11448304

Liao et al. discovered that Khib modification on NAT10 molecule can enhance its interaction with deubiquitinase and subsequently promote cancer metastasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Liao", "et", "al....

PMC11694066

E, Dose–response survival curves of JN1 cells exposed to PARPi talazoparib (F) or olaparib (G), and ATRi M4344 (H) or AZD6738 (I) for 7 days in the presence or absence of siRNA-mediated silencing of EWS–WT1 and/or RNase H1 overexpression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11267036

Collectively, these results suggest that DHM can inhibit MM tumor growth and EMT in vivo via STAT1/RIG-I activation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "these", "res...

PMC10758402

RevertAid First Strand cDNA Synthesis Kit was used to convert 1 ug of RNA to cDNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RevertAid", "First", "Strand", "cDNA", "Synthesis", "K...

PMC11033180

Cell-attached patch-clamp recordings were conducted to observe the spontaneous firing activity of individual enteric neurons while maintaining the cytoplasmic contents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell-attached", "patch-clamp", ...

PMC9429973

High resolution MFC improved the detection of BM infiltration, potentially affecting IPI score.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "resolution", "MFC", "improved", "the", "detection", "of", ...

PMC11785489

However, a causal pathway that begins with V(D)J recombination and ends with the T cell state likely includes several important biological mediators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...

PMC7840816

Our study showed that SOX9 was overexpressed in PTC tissues and cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "showed", "that", "SOX9", "was", "overexpressed", "in", ...

PMC10547921

Pettit et al. designed auristatin analogs 13–15 modified with C-terminal aromatic phosphate and quinoline, with an IC50 of 0.81, 0.19 and 6.35 nmol/L on McF-7 cells, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...

PMC11721587

Mammalian cells were transfected with PolyJet in vitro DNA transfection kit (SignaGen).

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PMC9429973

Classically, WHIM syndrome pathogenesis is causally linked to a variety of heterozygous gain-of-function mutations in the C-terminus of chemokine receptor CXCR4, a master regulator of immune cell trafficking and homeostasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11607764

Tumor-infiltrating immune cell subsets were reported to be associated with either better or worse prognosis in cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor-infiltrating", "immune", "cell", "subsets", ...

PMC11049294

The peak fluorescent intensity could be detected after 5 h of incubation (2776 ± 80.79 MFI).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "peak", "fluorescent", "intensity", ...

PMC11628904

We found that burn depth was unchanged 1 dpb regardless of treatment, highlighting that our burn wound paradigm was able to produce wounds of consistent depth.

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PMC11721096

To date, various affinity-based methods have been developed for this purpose, including ligand fishing , affinity ultrafiltration , and cell membrane affinity chromatography , among which ligand fishing based on immobilization of the target protein has drawn increasing attention due to its high specificity and ease of ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3681794

6–8 hours after transfection cells were incubated in hypoxia until drug exposure 32 hours after transfection (after 24 hours in hypoxia).

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PMC11502443

To allow comparison, data were normalized to GIP(1-42) at the WT receptor for each signaling pathway.

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PMC11773391

Our data showed that TMZ stimulation could activate the ERK signalling pathway in A375 cells, which in turn increased the promoter transcriptional activity of MGMT, indicating that after TMZ treatment, intracellular MGMT depletion increased and reserves decreased, but MGMT transcription could be enhanced.

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PMC9688728

The most (86%) metabolites are characterized by F-ratios ranging from 20 to 180.

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PMC11269792

Small interfering RNA targeting circAPP and CDV3, small interfering RNA negative control (si-circAPP: 5’-ATGGATGTTTGCGAAACTCATCT-3’, si-CDV3, si-NC), overexpression plasmid targeting circAPP and CDV3 and negative control (pcDNA 3.1-circAPP/CDV3, pcDNA 3.1) were supplied by RiboBio (Guangzhou, China), whereas miR-6838-5...

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PMC11394730

Among these, epigallocatechin gallate (EGCG), a major catechin in green tea, has shown the most potent antiproliferative effects.

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PMC9370419

We assumed that estradiol benzoate represses HBV replication and translation through the inhibition of the HBx protein.

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PMC11574029

Furthermore, CCK-8 assay results showed that SPP1 overexpression promoted tumor cell proliferation, but this effect disappeared after treatment with LY294002 (Fig. 4G, H).

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PMC11587541

The thermal profile setup for QPCR consisted of the following steps : an initial denaturation at 95 °C for 10-min, 45 cycles of 95° C hold for 15 s, followed by annealing at 60 °C for 30 s, and 72 °C hold for 11 s. Table 1Showing the primer sequence of different genes used during the studyGenePrimer sequenceTelomere_F5...

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PMC9509578

Lactic acid accumulation makes the intracellular environment acidic by increasing proton concentrations.

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PMC11791432

At the same time, U87 cells transfected with lentivirus stably interfering with ANXA1 (treatment group) and negative control group U87 cells were implanted into the skull of 6 BALB/c female mice (12 mice in total), and the survival time of mice was followed up to observe, the survival curve is shown in Fig. 7C.

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PMC8875242

Some of the tested antivirals can be extensively metabolized by CYP3A4 , resulting in less pronounced ABCB1 inhibition.

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PMC11680982

For HER2-low tumor volume on day 21: normal saline vs. medium-dose ET + CDK4/6i + Ner, P = 0.0001; normal saline vs. low-dose ET + CDK4/6i + Ner, P = 0.0017; normal saline vs. ET + CDK4/6i, P = 0.003; ET + CDK4/6i vs. medium-dose ET + CDK4/6i + Ner, P = 0.0021.

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PMC9429973

AML transformation of SF3B1 mutated MDS patients is determined by the entire genomic landscape indicating RUNX1 as potential driver.

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PMC11634027

For each wing, 35-70 wing hairs were examined and five or six wings were analyzed per genotype.

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PMC11216402

Because the Mes-like cell lines are epigenomically and transcriptionally similar to fibroblasts, we next sought to verify that they are not simply normal fibroblasts, or possibly CAFs (Sahai et al. 2020).

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PMC7053076

Overexpression of ATP-binding cassette (ABC) transporters in many types of cancer is responsible for the reduction of the cellular uptake of various anticancer drugs causing multidrug resistance (MDR), the major obstacle in cancer chemotherapy.

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PMC11468365

The DeepChem is an open-source library designed for applying deep learning to problems in chemistry, materials science, and biology.

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PMC9429973

In the absence of DLT, subsequent dose levels will increase sequentially according to a modified Fibonacci approach.

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PMC10759659

The clinical information of patients included in this study can be found in Supplementary file S1.

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PMC9429973

In order to prevent nephrotoxicity, Melphalan is often administrated with hyperhydration (HH) consisting of 4-6 Litres (L) 0.9% saline which has a potential fluid overload risk, mainly in elderly patients.

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PMC11661040

H-J) Western blot analysis confirmed that the overexpression of CGREF1 resulted in an upregulation of Cyclin D expression.

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PMC11742047

These values reflect the importance of each variable in the model both for Y, i.e., its correlation with all observations, and for X (the projection).

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PMC11237030

We characterised one clone, named clone 16, that was able to stably express AQP5 h on the plasma membrane and also intracellularly over time by means of immunofluorescence and Western blot analysis.

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PMC9429973

Early on-treatment changes in PB were associated with response to glofitamab: induction of IL-6, IFNγ, IL-10, and TNFα in the 6 hours after the first glofitamab dose was strongest in pts with CR (IL-6, IFNγ, IL-10: 6- to 16-fold induction; TNFα: 1.5-fold induction).

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PMC11790971

In addition, the ratios of cells with certain and uncertain labels were kept the same among all passages.

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PMC11607321

We initially tested 16 multi-omics integration methods (Supplementary Data 6, see Methods), but due to constraints such as the number of omics supported, type of data distribution, and limitations in design and implementation, we were narrowed to three state-of-the-art methods: MOFA, MOVE, and mixOmics.

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PMC4112127

Unmethylated copies were not targeted for amplification.

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PMC10748106

The MEP map provides a perception of the molecular size and the location of electron-rich and -deficient zones on a compound.

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PMC9780037

Cyt c nitrations at tyrosines 46 and 48 have impaired the formation of functional apoptosomes and might even promote cyt c degradation .

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PMC11583690

Based on the DTX loading capacity of 122.25 mg/g for BPMO and 120.33 mg/g for MSN, the DTX weight was calculated to correspond to 1 mg of free DTX.

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PMC11476837

These derivatives potentially increase the sensitivity of cancer cells to anticancer drugs such as sorafenib or regorafenib .

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PMC9444294

Studies utilizing anti-SS18 antibodies need to account for the concurrent presence of typically large amounts of wild-type SS18, as the fusion oncoprotein retains 410 out of the 418 amino acids present in full-length SS18.

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PMC11055510

The down-regulation of circMAN1A2 was the opposite of the up-regulation of circMAN1A2. (

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PMC11705630

Particularly, canonical driver genes of human cancer, such as MYC, can upregulate nucleotide synthesis by directly or indirectly inducing genes in nucleotide synthesis 6.

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PMC9368503

In addition, we show that the dual PI3K-mTOR inhibitor NVP-BEZ235 (also known as dactolisib) reduces the cell viability of ICR-SS-1 and the two other synovial sarcoma cell lines.

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PMC11075223

Prim-O-glucosylcimifugin (7.5 mg/kg, 15 mg/kg, 30 mg/kg) improved brain Cerebral ischemia/reperfusion (I/R) symptoms and neuronal apoptosis according to the number of errors in the step-down test and the neurological deficit score.

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PMC11806182

This may help explain why UCEC patients with high miR-424 expression had improved survival rates.

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PMC11257988

This dilemma was broken in 2013 when American chemical biologist Kevan Shokat discovered that when KRASG12C protein is in the inactive GDP-bound state, the switch II domain (SIIP) of its mutated cysteine residue exhibits a pocket structure that can covalently bind to small molecule drugs .

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PMC7602170

Conversely, PDGFRA-mutated GISTs are more prone to a benign behavior than those with codon 557/558 deletions .

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PMC9429973

Predictors of response 40 (39%) patients achieved complete remission (CR), 20 (19%) CR with incomplete hematological recovery (CRi), resulting in CR/CRi in 60 (58%) patients.

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PMC11627133

To create bifunctional AS1411‐RhoBAST as a DNA‐RNA conjugate, we ligated the 3′ end of in vitro transcribed RhoBAST with the 5′ end of single‐stranded AS1411 oligonucleotide (Figure S3A, B).

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PMC11033180

Plexin A1 was notably found at the periphery of the neuronal cell bodies suggesting a cell surface localization (Figures 2F and 2F′).

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PMC11538390

The human induced pluripotent stem cells (iPSCs), UCSFi001-A ([WTC11], Coriell Institute for Medical Research, Catalog no. GM25256), were maintained in mTeSR1 media (StemCell Technologies) on Matrigel (Corning) coated plates and passaged with Accutase.

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PMC9429973

Results: The study of the mean fluorescence intensity (MFI) of MSC markers revealed a significant decrease in MFI of CD274 (PD-L1) in primary patients compared to healthy donors and its absence on the cells of patients in remission.

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PMC10203589

In the same human breast cancer cell lines MDA-MB-453 and SK-BR-3, the mRNA levels of some proliferation-related genes, such as CCND2, CDK2 and Ki67, were significantly up-regulated when stimulated by recombinant FGF18 protein.

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PMC11794568

Studies have shown that in a variety of cancer types, mitochondrial biogenesis is activated to increase ATP production to support tumor growth and spread.

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PMC11413393

Individual knockdowns indicate PRMT1 as the specific critical dependency for cancer growth.

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PMC11122631

We also used the tool to predict the oral bioavailability of nine compounds (Figure S2).

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PMC6267596

We demonstrated that during 4-days of alisertib treatment, DH/DE-DLBCL cells become polyploid (≤4n).

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PMC6684588

Data are means ± SEM (n = 8–10). **

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PMC10243817

All work was carried out in accordance with the Declaration of Helsinki for experiments involving humans.

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PMC9429973

As for the cytogenetic aberrations, did not play an important role in the outcome of pPCL patients other than the presence of del(17p) which could impact OS in the univariate analysis.

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PMC11637284

The control experiments that the TAC60 mutants used in our study completely replace the endogenous TAC60 and are fully integrated into the TAC are provided in S6 and S7 Figs, respectively.

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PMC11782508

Fig. 6Antimicrobial activity of purified azurin against various bacterial strains.

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PMC11310713

In recent years, the field of 3-dimensional (3D) encapsulated cells has gained prominence as a promising approach to treating tissue and organ injuries, offering marked potential for advancing cell-based therapies .

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PMC9429973

The date of the point is in July 2021.

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PMC9429973

Pt characteristics are summarized in Table 1.

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PMC9118379

Although identified variant peptides pass an FDR of 1%, the results of 11 examinations reveal that the essential FDR criterion requirement is not sufficient to validate identified variant peptides.

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PMC11790599

Furthermore, TSL exhibits efficacy against lapatinib-resistant breast cancer cells, offering a promising avenue for breast cancer therapy.

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PMC11799620

Briefly, 1 ml of the OFAE (varying concentrations) was mixed with 1 ml phosphate buffer (20 mM, pH 7.4) containing ferric chloride (1 mM), EDTA (1 mM), deoxyribose (2.8 mM), 0.1 ml ascorbic acid (1 mM), and 0.5 ml hydrogen peroxide (20 mM).

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PMC11297139

The size and purity of the eluted proteins were analyzed by SDS–PAGE and Coomassie blue staining.

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PMC11687167

These experimental results above demonstrated that PCSK9 could regulate the TLR4/NF-κB signaling pathway through TLR4 independent of cellular lipid metabolism.

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PMC11401358

Due to the high molecular weight of SF, representative polypeptides e.g. (GAGSGA)2 and GAGVGAGY from SF heavy chains were chosen for the mechanistic study of the antioxidant effect.

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PMC11194678

Notably, small molecules that could specifically modulate biomolecular condensates have drawn great attention as therapeutics for neurodegenerative diseases and cancers (Richard et al., 2019, Preprint; Wang et al., 2023).

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PMC9429973

Methods: The RMR was searched for all patients with a diagnosis of WM.

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PMC10606998

Consequently, at the same absorbed dose, the radiation damage to the cells loaded with nanoparticles will be greater compared to the cells without nanoparticles.

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PMC9599726

Imatinib-sensitive (GIST882) and imatinib-resistant (GIST48) cells were treated with class II FIN RSL3, a direct GPX4 inhibitor for 3 h. We first assessed the cell viability.

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PMC8913139

Combined with these results, ROCK1 is considered to be an oncogene in GBM.

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PMC5925824

Whether these observations reflect a direct effect of PD-L1 blockade on innate immune cells or an indirect effect resulting from T cell activation, they underscore the diverse and to-date not fully appreciated role for PD-L1 blockade to modulate the activity and function of cell types beyond T lymphocytes, and highligh...

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PMC11752740

A fraction affected (Fa) of 0.5 represents the effective dose that kills 50% of the cells.

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PMC10890307

Understanding metabolic adaptive mechanisms for tumor cell survival may provide promising opportunities to improve traditional cancer therapies, considering that other conditions (lactic acidosis, hypoxia) should be tested when analyzing drug sensitivity.

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PMC9429973

Despite the paradigm shift in the treatment landscape, there is still a subset of patients with a worse prognosis.

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PMC11697065

Results are expressed as mean ± standard error of the mean (SEM).

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PMC3813807

The primer sequences used for the RT-PCR amplification are shown in Table I. All primers were synthesized by Sangon Biotech (Shanghai, China).

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PMC9895440

1.5 μl of these aligned crRNA-tracrRNA complexes was then incubated with 15 μl of 40 μM Cas9-NLS protein (Berkeley, QB3) for 30 min at room temperature in the dark and used immediately (referred to as Cas9-RNP).

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