OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Health appointments were changed in format for most, and more often in MM patients (Changes: 69% of MM, 52% of non-MM) –with oncologist/haematologist visits most affected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3734024	Viable B cells recovered from culture were quantified from replicate samples using a hemocytometer and trypan blue exclusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viable", "B", "cells", "recovered", "f...
PMC11594588	The reaction is not destructive and fully reversible (neither MitoXpress Xtra nor O2 are consumed), facilitating the measurement of time courses and antiplatelet, antithrombotic, and thrombolytic drug treatments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	Such impact of population structure on the association results was already predicted in a previous study showing a strong influence of ancestry composition on the HLA-G haplotype distribution in a healthy Brazilian population sample .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A clinically meaningful change was defined as 10 points for each EORTC QLQ-C30 score and 7 points for EQ-5D-5L VAS score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "clinically", ...
PMC11576293	Yield 82%; m. p. 220–221°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.13 (overlap d.d.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	Medium was replaced with complete DMEM virus collection media (Hepes, NEAA, BME, and FBS), and 48 hours later, viral supernatant was collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10545062	This duality is growing in importance as the demands to closely monitor and titrate medication treatments in the critical care setting coincide with decreasing provider bandwidth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11549612	Functional assays further underscore the importance of BOLA1, BOLA2, and BOLA3 in KIRC progression, as their knockdown inhibits cell growth and wound healing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC5415764	Similar to results published in a previous literature report, the characteristic resonance of active -CH proton of conjugated PTX shifted from about 4.6 ppm to 5.82 ppm, indicating that the esterification reaction between the active hydroxyl of PTX and PLGA-DTPA occurred preferentially33.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	However, co-treatment with Q-VD-OPh (QVD), a broad-spectrum caspase inhibitor, did not alleviate TSL-induced cell death (Supplementary Figure S4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11637284	It has a large domain exposed into the IMS which is associated with Mic19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "a", "large", "domain", "exposed", "into", "the", ...
PMC11727907	Although the function of PKM2 has been mainly investigated in cancer, it also plays a significant role in the retina.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", ...
PMC11545868	A tumor is a mass of cells that develops as a result of abnormal cell deregulation and soon becomes cancerous and invades surrounding tissue .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11599565	In order to isolate such cells, we employed MicroBeads directly conjugated to EpCAM antibody (Cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to", "isolate", "such",...
PMC3035438	Antigen-specific chicken IgM and chimeric IgG were detected by ELISA using apoferritin-coated immunoplates incubated with the culture supernatant samples and with respectively anti-chicken IgM and anti-human IgG secondary antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11521786	Statistical power was analyzed using the PASS 15.0.1 program, with results showing more than 85% statistical power for all corresponding cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statist...
PMC9429973	Summary/Conclusion: Active chronic GVHD was associated with impared QoL in patients after HSCT hence the need for rapid diagnosis and optimal prophylaxis and treatment of this complication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10578720	We first examined whether HBV stimulation could induce immunophenotypic polarization of macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "examined", "whether", "HBV", "stimulation", "could", "induce", "i...
PMC5025404	Based on the results of total productivity, growth characteristics, and stability, subclone 30 was selected for the further analysis (Fig. 3).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11740207	MIAMICs express key pluripotency genes, such as POU5F1P5 (synonym OCT4), SOX2, and NANOG, albeit at lower levels than ESCs or iPSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	They also used CSF1R inhibitor 2G2 and platinum-based chemotherapy to deplete TAMs and reduce Treg cell numbers, respectively, to enhance the response of KRAS tumors to A2 V and anti-PD-1 dual therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11611077	Lane 2: CHO cells transfected with His-tagged prestin (EF1α3C8).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lane", "2", ":", "CHO", "cells", "transfected", "with", "His-tagged", "...
PMC9429973	It is important to optimize chelation to reduce iron-associated morbidity and early mortality and to improve quality of life.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "important", "to", ...
PMC11790599	Images were captured with a JEOL JEM-1400 series 120 kV Transmission Electron Microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "captured", "with", "a", "JEOL", "JEM-1400", "series", ...
PMC10808409	The independent variables were X1: total Pluronics mixture (mg), (X2): Pluronic P123 percentage (%w/w), and (X3): drug amount (mg), whereas the dependant variables were the entrapment efficiency percentage (EE%) (Y1) and the particle size (Y2), as shown in Table 1.Table 1D-optimal design of FA polymeric mixed micelles,...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Cells with more than 2 nuclei were considered multinucleated syncytia, and nuclei per syncytia were counted manually.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "with", "more", "than", "2", ...
PMC11754432	Both gene expression (Fig. 4A) and Western analysis of EGFR revealed a significant decrease in total EGFR protein following ALOX15B silencing (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583690	Minh Tri Le: Supervision, Investigation, Formal analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Minh", "Tri", "Le", ":", "Supervision", ",", "Investigation", ",", "Formal", "analysis", "...
PMC8973725	The influence of ZNF factors on EMT and cancer invasion has been confirmed in various cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "influence", "of", "ZNF", "factors", "on", ...
PMC11604015	The transient CAR expression technologies do not integrate vectors into the genome, so that it can avoid potential genotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transient", "CAR", ...
PMC11791432	Then, according to the composition pattern of marker genes and the reported glioma cell marker bases(CADM1 ,CLCC1 ,HMOX1 ,SCAMP3 ,SLC16A1 ,CD133 ,CD15 ,NANOG ,SOX2 ,CD90 ,GD2 ,Musashi1 ,Nestin ,CDH5 ), using manual annotation combined with singleR software Package annotates in a way that identifies and annotates differ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	Finally, such a strategy should ideally be broadly applicable to target any endogenous condensate-forming protein of interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "such", "a", "strategy"...
PMC11770199	mMSC was purchased from Culture Collection of Tongpai Biotechnology Co. Ltd. (Shanghai, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mMSC", "was", "purchased", "from", "Culture", "Collect...
PMC9429973	Results: As of October 1, 2021, 12 pts received LD; 11 were administered UCART22, of which 6 received UCART22 after FCA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11534377	Through evaluation using NSCLC cell lines and xenograft animal models, we aim to determine how 5-Aza and IR impact cell survival, apoptosis, and gene expression, and assess the feasibility of this approach as a potential treatment for NSCLC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	Ber, MPP and Rot increased the glucose consumption rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ber", ",", "MPP", "and", "Rot", "increased", "the", "glucose", "consumption", "rate", "." ...
PMC9275501	Wang et al. (2015b) synthesized PTX and BCL prodrugs containing FA and HA dual targeting ligands, and prepared multifunctional self-assembled nanoparticles for delivery of PTX prodrug and BCL prodrug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11763126	A Sequence information of CBDP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Sequence", "information", "of", "CBDP1", "." ] } ]
PMC11680562	Simultaneously, the pH values of the gels were assessed to determine their suitability for vaginal application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Simultaneously", ",", "the", "pH", "values", ...
PMC9611901	The main components of natural leather are proteins—collagen, keratin, elastin and reticulin—which make up about 33% of leather.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	FBC and a peripheral blood smear are inexpensive, easily performed, rapid tests which could add some novelty as effective markers of disease progress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11377827	HeLa USP43 KO or overexpressing cells were seeded at 3 × 10 cells in six-well plates the night before.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HeLa", "USP43", "KO", "o...
PMC9429973	Treatment options in relapse settings are limited and outcome is usually poor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "options", "in", "relapse", "settings", "are", "limited", "and", "ou...
PMC11678448	They were provided with a standard diet and allowed free access to food and water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "were", "provided", "with", "a", "standard", "diet",...
PMC10965315	Harmaline induced apoptosis in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Harmaline", "induced", "apoptosis", "in", "ovarian", "cancer", "cells", "." ] } ]
PMC11612315	Typically, GLP-1 secretion in response to oral glucose is more pronounced than that in response to other administration routes, suggesting a significant opportunity for future investigations to directly examine the analgesic effects of oral glucose through its impact on GLP-1 levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7823217	Amongst the recent 3D models, utilization of spherical models has shown the most promise, which in combination with appropriate microenvironment and biomaterials could revolutionize in vitro personalized drug screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Homocysetine was significantly (p <0.001) in patients (17.42 ± 8.5 µmol / L) compared to controls (9.41 ± 3.1 µmol / L), with a prevalence of hyperhomocysteinemia (defined by a homocysteine level> 15 µmol / L) of 61.7% in the patients against 4% in the controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	was developed to treat perimenopausal symptoms including depression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "was", "developed", "to", "treat", "perimenopausal", "symptoms", "including", "depression", "." ] } ]
PMC9429973	In total 42 patients died.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "total", "42", "patients", "died", "." ] } ]
PMC9878562	In culture the majority of cells do not express the receptor on the plasma membrane, despite the presence of similar levels of transcripts in receptor positive and negative cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994	We also compared two methods of exposition: solutions were added either to a sub-confluent layer or to the cell suspension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "com...
PMC10589262	Treatment with each ATF6 inhibitor potently downregulated cATF6 and KIT levels (Fig. 5C and Supplementary Fig. S15).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "each", "ATF6...
PMC11496728	After 48 h, a stable cell pool was obtained by puromycin screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "48", "h", ",", "a", "stable", "cell", "pool", "was", "...
PMC11401358	Since oxidation induced secondary structure changes in SF from β-sheets into random coils, we wondered whether the increase in β-sheet structures can promote stronger antioxidants in SF solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676674	The cytotoxic activity of C. monspeliensis extract at different concentrations with MMC (0.025 μg/mL) was assessed via the determination of CN and CBPI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11727638	Both TK and KML-1 cells also proliferated in the high-density Cell Domes as the incubation period increased (Figure 4a,b).	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC9429973	Methods: This is a case control study conducted in Hospital de Clinicas Montevideo, Uruguay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "This", "is", "a", "case", "contr...
PMC9429973	Hence, we elucidated the hierarchical structure of hematopoietic cells, interaction of leukemic cells with the microenvironment, and changes in signaling response to chemotherapy in vivo treatment by mass spectrometry (CyTOF) to validate the identified altered signaling pathway activities at protein level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607764	Our study is the first to demonstrate the oncogenic role of PTBP1 in a pan-cancer context.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "study", "is", "the", "first", "to", "demo...
PMC10582049	Proportion of stromal cell subpopulations in relation to patients. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proportion", "of", "stromal", "cell", "subpopulations", "in", "relation", "to", "patients", ".",...
PMC8357004	The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	At a median follow-up of 13.2m, median OS was not reached (1-year OS 68.6%) in the HMA-naïve cohort and 8.3m (1-year OS 22%) in the HMA-failure cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	The presence of δ2 T cells was assessed by flow cytometry in peripheral blood of mice receiving γ9δ2 T cell infusions for 3, 7, and 11 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750696	Given the critical role of protein synthesis in T cell activation, UPR are increasingly recognized as key players in regulating T cell function and immunity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11525293	A HaCaT and A431 cells were transiently transfected with 100 and 250 ng of CRBN encoding plasmid.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "HaCaT", "and", "A431", "ce...
PMC11297139	We also found that the genes activated by ARID1A LLPS were markedly linked to the upregulated cREs whereas the repressed genes were linked to the downregulated cREs (Fig. 5b and Supplementary Fig. 13b), indicating the dysregulated cREs controlled by ARID1A LLPS are closely related to altered gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7348793	Moreover, the repeat region in the COS-7 cells was the longest among those examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "repeat", "region", "in", "...
PMC10114490	Filled bars: NES < 0, enriched in PD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Filled", "bars", ":", "NES", "<", "0", ",", "enriched", "in", "PD", "." ] } ]
PMC11708541	Of them, compound urea derivative 84 exhibited good selectivity and substantial inhibitory action against CDK8 with an IC50 value of 46 nM. Additionally, there appeared a relationship between biotinylated-81 and endogenous or overexpressed CDK8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	A Volcano plot of differentially expressed genes between A-673 cells transfected with siRNA KCNA2 (siRNA KCNA2) or siRNA control (siRNA CT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC4695073	Down-regulating XPA expression or expressing a competitive, nonfunctional truncated XPA decreases the platinum resistance in lung cancer and prostate cancer DU15 cell lines, but not in prostate cancer PC3 cells [12-15].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC7570809	Thus, it is definitively clear that β5 integrin can be considered a diagnostic biomarker and a potential therapeutic target in HCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC11499381	The InFusion reaction was performed according to manufacturer's protocol, adding 50–100 ng insert DNA, 20–30 ng vector DNA, 1 µL of InFusion reaction mix, and UltraPure H2O, for a total volume of 5 µL. The mix was incubated at 50°C for 15 min, then placed on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	Wnt pathway gene expression levels were compared during induced differentiation and many components were altered including ligands (WNT2B), receptors (FZD5, FZD6, FZD10), secreted inhibitors (SFRP4, SFRP1), and other effectors of Wnt signalling (FRAT2, DAAM1, PITX2, Porcupine).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11449273	We next investigated the effects of plakoglobin on the subcellular distribution of β-catenin and nucleophosmin (NPM) that have been linked to plakoglobin anti-tumor roles in cancer cells [35, 57–59].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5034105	Although ZIKV infection has been described as a dengue-like illness in the past, recent evidence suggests that ZIKV is unique among known human-pathogenic flaviviruses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10079526	B, C respectively show volcano plots visualizing all identified SUMOylated proteins in U2OS His10-SUMO2 upon 4 or 20 h of 5-Aza-2’ treatment (1 µM) compared to control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	We assessed the performance of the FLCCR system in genetic backgrounds known to potentially influence the duration of the G2 phase, resulting in cells longer than wild-type cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10421378	Commonly used classical microbiological methods are, however, unable to detect this important subpopulation, which could be included in viable cell counts for the assessment of probiotics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721295	Interestingly, expression of Chil3, Cd274, and Arg1 appeared to require additional factors stemming from CAFs; while their expression was induced by culture in FB CM, Retnla expression was reduced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973085	calcd for C24H20FN3O2S: C, 66.50; H, 4.65; N, 9.69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "calcd", "for", "C24H20FN3O2S", ":", "C", ",", "66.50", ...
PMC11476837	Overcoming doxorubicin resistance clinically requires both the study of the molecular mechanism of cancer cells resistance to doxorubicin and the exploration of new strategies to reverse doxorubicin resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10006224	The same analysis was applied to data from NIPBL KD cells (Supplementary Data 2) and data previously obtained for STAG2 KD cells (Supplementary Data 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11290772	Furthermore, a comparative analysis of the cytolytic activity was performed among PBMC-NK, ROBO1-NK, and Mock-CAR-NK cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "a", "comparat...
PMC11707832	Class I α-mannosidases exhibit a molecular mass ranging from 63 to 73 kDa and possess a conserved sequence belonging to the glycoside hydrolase 47 family.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7215722	Total lipids from the sucrose gradient fractions were extracted by the method of Bligh and Dyer with slight modifications, as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total",...
PMC11283030	This study was approved by the Ethical Committee of The First Affiliated Hospital of 10.13039/501100015507Shandong First Medical University (2016-S017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "...
PMC11767793	Furthermore, positively charged PSNPs were even considered as positive controls for in vitro testing standardization; however, an interlaboratory study revealed that they lack sufficient colloidal stability .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8759873	We note the similarity in expression level of VHL mRNA in 786-0 cells infected with pcDNA3.1 (+) (P > 0.05), as shown by Figure 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11623887	The virus enters the cells via P antigen and coreceptors and induces infection and cell apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "virus", "enters", "the", "cells", "via", ...
PMC8864075	The primers were as follows: TWIST1 (forward: 5′-TCGGACAAGCTGAGAGCAAGATTCA-3′, reverse: 5′-TCCATCCTCCAGACCGAGAAGG-3′), GAPDH (forward: 5′-CATGAGAAGTATGACAACAGCCT-3′, reverse: 5′-AGTCCTTCCACGATACCAAAGT-3′).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "information", "on", "research", "desig...
PMC11594641	A lower amount of CD63 was detected in RAB27A KO DMBC12 cells compared to WT DMBC12 cells, while the other markers remained at similar levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11352746	Nevertheless, the highest frequency of imaging that cells endure under experimental conditions can be determined by adjusting the time period between successive images .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11469524	The principle is that a specific antibody coupled to a color-coded bead identifies the total protein of interest while a second detection antibody determines the magnitude of a distinct phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11773391	This further echoed our experimental results that the transcription of MGMT was not high in melanoma in the absence of drugs but could be strengthened compensatively after exposure to TMZ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	B Tumor growth was evaluated by In vivo imaging system (IVIS) for all three different orthotopically models (200′000 cell/mice).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ...
PMC9429973	The ARU-1801 manufacturing process uses a proprietary methodology to prevent HSC differentiation in culture, which may favor transduction of long-term HSCs over short-term progenitor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Health appointments were changed in format for most, and more often in MM patients (Changes: 69% of MM, 52% of non-MM) –with oncologist/haematologist visits most affected.

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PMC3734024

Viable B cells recovered from culture were quantified from replicate samples using a hemocytometer and trypan blue exclusion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viable", "B", "cells", "recovered", "f...

PMC11594588

The reaction is not destructive and fully reversible (neither MitoXpress Xtra nor O2 are consumed), facilitating the measurement of time courses and antiplatelet, antithrombotic, and thrombolytic drug treatments .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9954564

Such impact of population structure on the association results was already predicted in a previous study showing a strong influence of ancestry composition on the HLA-G haplotype distribution in a healthy Brazilian population sample .

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PMC9429973

A clinically meaningful change was defined as 10 points for each EORTC QLQ-C30 score and 7 points for EQ-5D-5L VAS score.

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PMC11576293

Yield 82%; m. p. 220–221°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.13 (overlap d.d.,

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PMC11777207

Medium was replaced with complete DMEM virus collection media (Hepes, NEAA, BME, and FBS), and 48 hours later, viral supernatant was collected.

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PMC10545062

This duality is growing in importance as the demands to closely monitor and titrate medication treatments in the critical care setting coincide with decreasing provider bandwidth.

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PMC11549612

Functional assays further underscore the importance of BOLA1, BOLA2, and BOLA3 in KIRC progression, as their knockdown inhibits cell growth and wound healing.

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PMC5415764

Similar to results published in a previous literature report, the characteristic resonance of active -CH proton of conjugated PTX shifted from about 4.6 ppm to 5.82 ppm, indicating that the esterification reaction between the active hydroxyl of PTX and PLGA-DTPA occurred preferentially33.

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PMC11790599

However, co-treatment with Q-VD-OPh (QVD), a broad-spectrum caspase inhibitor, did not alleviate TSL-induced cell death (Supplementary Figure S4A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11637284

It has a large domain exposed into the IMS which is associated with Mic19.

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PMC11727907

Although the function of PKM2 has been mainly investigated in cancer, it also plays a significant role in the retina.

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PMC11545868

A tumor is a mass of cells that develops as a result of abnormal cell deregulation and soon becomes cancerous and invades surrounding tissue .

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PMC11599565

In order to isolate such cells, we employed MicroBeads directly conjugated to EpCAM antibody (Cat. #

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PMC3035438

Antigen-specific chicken IgM and chimeric IgG were detected by ELISA using apoferritin-coated immunoplates incubated with the culture supernatant samples and with respectively anti-chicken IgM and anti-human IgG secondary antibodies.

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PMC11521786

Statistical power was analyzed using the PASS 15.0.1 program, with results showing more than 85% statistical power for all corresponding cases.

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PMC9429973

Summary/Conclusion: Active chronic GVHD was associated with impared QoL in patients after HSCT hence the need for rapid diagnosis and optimal prophylaxis and treatment of this complication.

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PMC10578720

We first examined whether HBV stimulation could induce immunophenotypic polarization of macrophages.

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PMC5025404

Based on the results of total productivity, growth characteristics, and stability, subclone 30 was selected for the further analysis (Fig. 3).Fig.

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PMC11740207

MIAMICs express key pluripotency genes, such as POU5F1P5 (synonym OCT4), SOX2, and NANOG, albeit at lower levels than ESCs or iPSCs.

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PMC11257988

They also used CSF1R inhibitor 2G2 and platinum-based chemotherapy to deplete TAMs and reduce Treg cell numbers, respectively, to enhance the response of KRAS tumors to A2 V and anti-PD-1 dual therapy.

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PMC11611077

Lane 2: CHO cells transfected with His-tagged prestin (EF1α3C8).

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PMC9429973

It is important to optimize chelation to reduce iron-associated morbidity and early mortality and to improve quality of life.

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PMC11790599

Images were captured with a JEOL JEM-1400 series 120 kV Transmission Electron Microscope.

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PMC10808409

The independent variables were X1: total Pluronics mixture (mg), (X2): Pluronic P123 percentage (%w/w), and (X3): drug amount (mg), whereas the dependant variables were the entrapment efficiency percentage (EE%) (Y1) and the particle size (Y2), as shown in Table 1.Table 1D-optimal design of FA polymeric mixed micelles,...

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PMC11770199

Cells with more than 2 nuclei were considered multinucleated syncytia, and nuclei per syncytia were counted manually.

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PMC11754432

Both gene expression (Fig. 4A) and Western analysis of EGFR revealed a significant decrease in total EGFR protein following ALOX15B silencing (Fig. 4B).

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PMC11583690

Minh Tri Le: Supervision, Investigation, Formal analysis.

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PMC8973725

The influence of ZNF factors on EMT and cancer invasion has been confirmed in various cancers.

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PMC11604015

The transient CAR expression technologies do not integrate vectors into the genome, so that it can avoid potential genotoxicity.

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PMC11791432

Then, according to the composition pattern of marker genes and the reported glioma cell marker bases(CADM1 ,CLCC1 ,HMOX1 ,SCAMP3 ,SLC16A1 ,CD133 ,CD15 ,NANOG ,SOX2 ,CD90 ,GD2 ,Musashi1 ,Nestin ,CDH5 ), using manual annotation combined with singleR software Package annotates in a way that identifies and annotates differ...

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PMC11306331

Finally, such a strategy should ideally be broadly applicable to target any endogenous condensate-forming protein of interest.

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PMC11770199

mMSC was purchased from Culture Collection of Tongpai Biotechnology Co. Ltd. (Shanghai, China).

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PMC9429973

Results: As of October 1, 2021, 12 pts received LD; 11 were administered UCART22, of which 6 received UCART22 after FCA.

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PMC11534377

Through evaluation using NSCLC cell lines and xenograft animal models, we aim to determine how 5-Aza and IR impact cell survival, apoptosis, and gene expression, and assess the feasibility of this approach as a potential treatment for NSCLC.

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PMC10812665

Ber, MPP and Rot increased the glucose consumption rate.

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PMC9275501

Wang et al. (2015b) synthesized PTX and BCL prodrugs containing FA and HA dual targeting ligands, and prepared multifunctional self-assembled nanoparticles for delivery of PTX prodrug and BCL prodrug.

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PMC11763126

A Sequence information of CBDP1.

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PMC11680562

Simultaneously, the pH values of the gels were assessed to determine their suitability for vaginal application.

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PMC9611901

The main components of natural leather are proteins—collagen, keratin, elastin and reticulin—which make up about 33% of leather.

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PMC9429973

FBC and a peripheral blood smear are inexpensive, easily performed, rapid tests which could add some novelty as effective markers of disease progress.

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PMC11377827

HeLa USP43 KO or overexpressing cells were seeded at 3 × 10 cells in six-well plates the night before.

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PMC9429973

Treatment options in relapse settings are limited and outcome is usually poor.

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PMC11678448

They were provided with a standard diet and allowed free access to food and water.

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PMC10965315

Harmaline induced apoptosis in ovarian cancer cells.

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PMC11612315

Typically, GLP-1 secretion in response to oral glucose is more pronounced than that in response to other administration routes, suggesting a significant opportunity for future investigations to directly examine the analgesic effects of oral glucose through its impact on GLP-1 levels.

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PMC7823217

Amongst the recent 3D models, utilization of spherical models has shown the most promise, which in combination with appropriate microenvironment and biomaterials could revolutionize in vitro personalized drug screening.

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PMC9429973

Homocysetine was significantly (p <0.001) in patients (17.42 ± 8.5 µmol / L) compared to controls (9.41 ± 3.1 µmol / L), with a prevalence of hyperhomocysteinemia (defined by a homocysteine level> 15 µmol / L) of 61.7% in the patients against 4% in the controls.

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PMC11075223

was developed to treat perimenopausal symptoms including depression.

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PMC9429973

In total 42 patients died.

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PMC9878562

In culture the majority of cells do not express the receptor on the plasma membrane, despite the presence of similar levels of transcripts in receptor positive and negative cells.

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PMC7987994

We also compared two methods of exposition: solutions were added either to a sub-confluent layer or to the cell suspension.

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PMC10589262

Treatment with each ATF6 inhibitor potently downregulated cATF6 and KIT levels (Fig. 5C and Supplementary Fig. S15).

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PMC11496728

After 48 h, a stable cell pool was obtained by puromycin screening.

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PMC11401358

Since oxidation induced secondary structure changes in SF from β-sheets into random coils, we wondered whether the increase in β-sheet structures can promote stronger antioxidants in SF solution.

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PMC11676674

The cytotoxic activity of C. monspeliensis extract at different concentrations with MMC (0.025 μg/mL) was assessed via the determination of CN and CBPI.

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PMC11727638

Both TK and KML-1 cells also proliferated in the high-density Cell Domes as the incubation period increased (Figure 4a,b).

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PMC9429973

Methods: This is a case control study conducted in Hospital de Clinicas Montevideo, Uruguay.

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PMC9429973

Hence, we elucidated the hierarchical structure of hematopoietic cells, interaction of leukemic cells with the microenvironment, and changes in signaling response to chemotherapy in vivo treatment by mass spectrometry (CyTOF) to validate the identified altered signaling pathway activities at protein level.

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PMC11607764

Our study is the first to demonstrate the oncogenic role of PTBP1 in a pan-cancer context.

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PMC10582049

Proportion of stromal cell subpopulations in relation to patients. (

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PMC8357004

The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.

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PMC9429973

At a median follow-up of 13.2m, median OS was not reached (1-year OS 68.6%) in the HMA-naïve cohort and 8.3m (1-year OS 22%) in the HMA-failure cohort.

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PMC10024132

The presence of δ2 T cells was assessed by flow cytometry in peripheral blood of mice receiving γ9δ2 T cell infusions for 3, 7, and 11 days.

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PMC11750696

Given the critical role of protein synthesis in T cell activation, UPR are increasingly recognized as key players in regulating T cell function and immunity.

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PMC11525293

A HaCaT and A431 cells were transiently transfected with 100 and 250 ng of CRBN encoding plasmid.

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PMC11297139

We also found that the genes activated by ARID1A LLPS were markedly linked to the upregulated cREs whereas the repressed genes were linked to the downregulated cREs (Fig. 5b and Supplementary Fig. 13b), indicating the dysregulated cREs controlled by ARID1A LLPS are closely related to altered gene expression.

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PMC7348793

Moreover, the repeat region in the COS-7 cells was the longest among those examined.

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PMC10114490

Filled bars: NES < 0, enriched in PD.

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PMC11708541

Of them, compound urea derivative 84 exhibited good selectivity and substantial inhibitory action against CDK8 with an IC50 value of 46 nM. Additionally, there appeared a relationship between biotinylated-81 and endogenous or overexpressed CDK8.

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PMC11657695

A Volcano plot of differentially expressed genes between A-673 cells transfected with siRNA KCNA2 (siRNA KCNA2) or siRNA control (siRNA CT).

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PMC4695073

Down-regulating XPA expression or expressing a competitive, nonfunctional truncated XPA decreases the platinum resistance in lung cancer and prostate cancer DU15 cell lines, but not in prostate cancer PC3 cells [12-15].

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PMC7570809

Thus, it is definitively clear that β5 integrin can be considered a diagnostic biomarker and a potential therapeutic target in HCC.

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PMC11499381

The InFusion reaction was performed according to manufacturer's protocol, adding 50–100 ng insert DNA, 20–30 ng vector DNA, 1 µL of InFusion reaction mix, and UltraPure H2O, for a total volume of 5 µL. The mix was incubated at 50°C for 15 min, then placed on ice.

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PMC2777936

Wnt pathway gene expression levels were compared during induced differentiation and many components were altered including ligands (WNT2B), receptors (FZD5, FZD6, FZD10), secreted inhibitors (SFRP4, SFRP1), and other effectors of Wnt signalling (FRAT2, DAAM1, PITX2, Porcupine).

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PMC11449273

We next investigated the effects of plakoglobin on the subcellular distribution of β-catenin and nucleophosmin (NPM) that have been linked to plakoglobin anti-tumor roles in cancer cells [35, 57–59].

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PMC5034105

Although ZIKV infection has been described as a dengue-like illness in the past, recent evidence suggests that ZIKV is unique among known human-pathogenic flaviviruses.

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PMC10079526

B, C respectively show volcano plots visualizing all identified SUMOylated proteins in U2OS His10-SUMO2 upon 4 or 20 h of 5-Aza-2’ treatment (1 µM) compared to control.

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PMC11706491

We assessed the performance of the FLCCR system in genetic backgrounds known to potentially influence the duration of the G2 phase, resulting in cells longer than wild-type cells.

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PMC10421378

Commonly used classical microbiological methods are, however, unable to detect this important subpopulation, which could be included in viable cell counts for the assessment of probiotics.

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PMC11721295

Interestingly, expression of Chil3, Cd274, and Arg1 appeared to require additional factors stemming from CAFs; while their expression was induced by culture in FB CM, Retnla expression was reduced.

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PMC8973085

calcd for C24H20FN3O2S: C, 66.50; H, 4.65; N, 9.69.

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PMC11476837

Overcoming doxorubicin resistance clinically requires both the study of the molecular mechanism of cancer cells resistance to doxorubicin and the exploration of new strategies to reverse doxorubicin resistance.

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PMC10006224

The same analysis was applied to data from NIPBL KD cells (Supplementary Data 2) and data previously obtained for STAG2 KD cells (Supplementary Data 3).

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PMC11290772

Furthermore, a comparative analysis of the cytolytic activity was performed among PBMC-NK, ROBO1-NK, and Mock-CAR-NK cells.

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PMC11707832

Class I α-mannosidases exhibit a molecular mass ranging from 63 to 73 kDa and possess a conserved sequence belonging to the glycoside hydrolase 47 family.

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PMC7215722

Total lipids from the sucrose gradient fractions were extracted by the method of Bligh and Dyer with slight modifications, as described previously .

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PMC11283030

This study was approved by the Ethical Committee of The First Affiliated Hospital of 10.13039/501100015507Shandong First Medical University (2016-S017).

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PMC11767793

Furthermore, positively charged PSNPs were even considered as positive controls for in vitro testing standardization; however, an interlaboratory study revealed that they lack sufficient colloidal stability .

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PMC8759873

We note the similarity in expression level of VHL mRNA in 786-0 cells infected with pcDNA3.1 (+) (P > 0.05), as shown by Figure 1.

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PMC11623887

The virus enters the cells via P antigen and coreceptors and induces infection and cell apoptosis.

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PMC8864075

The primers were as follows: TWIST1 (forward: 5′-TCGGACAAGCTGAGAGCAAGATTCA-3′, reverse: 5′-TCCATCCTCCAGACCGAGAAGG-3′), GAPDH (forward: 5′-CATGAGAAGTATGACAACAGCCT-3′, reverse: 5′-AGTCCTTCCACGATACCAAAGT-3′).

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PMC11224020

Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.

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PMC11594641

A lower amount of CD63 was detected in RAB27A KO DMBC12 cells compared to WT DMBC12 cells, while the other markers remained at similar levels.

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PMC11352746

Nevertheless, the highest frequency of imaging that cells endure under experimental conditions can be determined by adjusting the time period between successive images .

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PMC11469524

The principle is that a specific antibody coupled to a color-coded bead identifies the total protein of interest while a second detection antibody determines the magnitude of a distinct phosphorylation.

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PMC11773391

This further echoed our experimental results that the transcription of MGMT was not high in melanoma in the absence of drugs but could be strengthened compensatively after exposure to TMZ.

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PMC11656657

B Tumor growth was evaluated by In vivo imaging system (IVIS) for all three different orthotopically models (200′000 cell/mice).

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PMC9429973

The ARU-1801 manufacturing process uses a proprietary methodology to prevent HSC differentiation in culture, which may favor transduction of long-term HSCs over short-term progenitor cells.

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