OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11680562	The finding is substantiated by the persistent existence of unique peaks in all spectra, suggesting the drug's compatibility with the other components in the PXFCu anticancer gel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9105697	Quantification of ctDNA is challenging, as minute amounts of mutated DNA fragments have to be detected in a large background of unmutated DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Results: Summary/Conclusion: Hematological complications commonly reported following COVID-19 vaccination were thrombosis with thrombocytopenia syndrome following AstraZeneca vaccination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Summary/Conclusion", ...
PMC6487404	The tested inhibitors caused a 2.6 to 3-fold increase in the REG permeability (P < 0.01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tested", "inhibitors", "caused", ...
PMC10745221	The HCT116 and HeLa cells showed a very similar banding pattern with both the SDMA and ADMA antibodies.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HCT116", "and", "He...
PMC9398137	These data support the hypothesis that occupational status of MCL1 protein belong to the key factors predicting sensitivity to S63845.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "support", ...
PMC9111184	In fact, in presence of cholesterol, all tested compounds could permeate the Caco-2 monolayer with a percentage ranging from 7.72 to 14.15 and a Papp values between 1.34 and 2.45 10− cm s (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787355	The TCR was comprehensively examined in vitro and in vivo for its anti-tumor activity against experimental flank and brain tumors, primary glioblastoma cell lines, and IPTOs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6267596	Of the up-regulated genes, 11 genes are involved in DNA repair (EXO1, CLSPN, XRCC3, NABP2, XRCC2, FANCD2, TREX2, TDG, MUS81, MTOR, POLQ), all of which showed a ≥2-fold increase in expression (shown in red squares).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257988	It is generally believed that the difficulty in developing direct KRAS inhibitors is due in part to the pico-molar affinity of GTP and GDP for KRAS (which have much higher cellular concentrations) and to the lack of suitable deep pockets for conformational regulation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659	Therefore, we have mainly focused on HBV-HCC in the current study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "have", "mainly", "focused", "on", "HBV-HCC", "in", ...
PMC11621565	Although a pathogen has not been identified, this hypothesis points out the notable role of the gastrointestinal tract and nasal cavity in the initiation of α-synuclein aggregation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9370419	In HBV infection, our findings may serve as an exploration of the anti-HBV molecular mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "HBV", "infection", ",", "our", "findings", ...
PMC6948907	1998; Grignani et al., 1998; Lin et al., 1998).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1998", ";", "Grignani", "et", "al.", ",", "1998", ";", "Li...
PMC9429973	Methods: BCL2 and MYC protein expression were assessed by IHC and identified as IHC+ (≥50% [BCL2]/≥40% [MYC]) or IHC−; MYC-R, BCL2-R, and BCL6-R were detected by fluorescence in situ hybridization (Tilly et al. NEJM 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	Data from n = 31 α2β3γ2-GABAAR/NL2-, n = 32 α2β3δγ2ICL-GABAAR/NL2-, and n = 30 α2β3δ-GABAAR/NL2-expressing HEK293 cells, from N = 2 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10335954	Early DNA damage to gastric mucosa leads to an increase in NF-κB expression, which subsequently promotes the release of inflammatory mediators in the cancer tissue compared with adjacent normal mucosa of stomach cancer (Yin et al. 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11539788	E-H) western blot analyses of ILK protein levels in BCa cells with stable overexpression or knockdown of RNF19A and quantitative analyses. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E-H", ...
PMC9587298	On the other hand, no significant changes in the amount of cyanidin-3,5-diglucoside and cyanidin-3-sambubioside-5-glucoside were observed, suggesting that under the conditions used in this work, diglycosylated anthocyanins do not trap MGO (Fig. 1c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	UCEC is characterized by a wide range of molecular and genetic alterations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UCEC", "is", "characterized", "by", "a", "wide", "range", "of", "molecular", ...
PMC8728081	The rate of temperature increase was 10 °C/min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rate", "of", "temperature", "increase", "was", "10", "°", "C/min", "." ] } ]
PMC11144200	Furthermore, these liposomes endocytosed into tumor cells and accumulate in the tumor tissue after administration, followed by inhibition of tumor cells DNA synthesis and strong induction apoptosis through the release of DOX.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	As we do not know if the GWAS-identified SNPs are the causal variants or just markers of risk, the functional characterization of the causal risk variants would lead to a better understanding of disease development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10237474	The full MS scan was acquired over the m/z range 500–3500.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full", "MS", "scan", "was", "acquired", "over", "the", "m/z", "range", "...
PMC11422150	This study evaluates the therapeutic potential of intravenously administered hAMSCs in SCI models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "evaluates", "the", "therapeutic", "potential", "of", "intr...
PMC6600592	Colorless liquid, yield 81.7%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colorless", "liquid", ",", "yield", "81.7", "%", "." ] } ]
PMC11543935	Fiber-like structures occur throughout this segment marked with a yellow arrow.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fiber-like", "structures", "occur", "throughout", "this", "segment", "marked", "with", "a",...
PMC11718274	This effect is primarily attributed to the generation of excessive reactive oxygen species (ROS), which ultimately disrupts mitochondrial membrane integrity, induces DNA damage and oxidative stress triggering apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6642070	Statins have been reported to increase phosphorylation of MDM2 at Ser166, which can promote p53 degradation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statins", "have", "been", "reported", "to", ...
PMC7504302	The only frontline chemotherapy regimen approved for clinical use in advanced stage MPM is the combination of platin and pemetrexed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "only", "frontline", ...
PMC7351993	When the FSC signal intensity exceeds a predetermined threshold, the TM node generates a trigger signal for the DA node array to initiate SRS image acquisition as well as for the TM node internally to initiate the calculation of the sort time with the predetermined sort latency.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	The scale bar is 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "is", "10", "μm", "." ] } ]
PMC9341513	Healthy cells.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Healthy", "cells", "." ] } ]
PMC11562028	It showed that the regulating trends of the nine genes (COL6A3, ITGA1, ITGB6, PTK2, PIK3CA, AKT3, CDKN1A, CDK2 and CCNA2) verified by the qPCR were consistent with the transcriptome test data (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	In short, PED2 and PED4 exhibited optimal fiber micromorphology when the PF-127 content was 15%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "short", ",", "PED2", "and", "PED4", ...
PMC11122631	This subfraction was further purified by reverse-phase HPLC (phenyl-hexyl column) eluted with 50% acetonitrile, and compound 2 (0.6 mg) was obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11286266	Considering the crucial role of trafficking in ATF6α activation, we next investigated whether depletion of CRT affected the stress-induced localisation of ATF6α by comparing the subcellular localisation of ATF6α in parental and CRT∆ cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	Media was changed after 6 h. After 48 h, cells were selected with 2 μg/ml blasticidin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Media", "was", "changed", "after", "6", "h....
PMC4659567	A fluorescence spectrum of free 5Faza is inserted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "fluorescence", "spectrum", "of", "free", "5Faza", "is", "inserted", "." ] } ]
PMC11188874	C, Effect of HDAC6 inhibitors on CTL-mediated tumor lysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Effect", "of", "HDAC6", "inhibitors", "on", "CTL-mediated", "tumor", "lysis", "....
PMC11676169	This was performed in CUTLL1 T-ALL cells that express undetectable levels of endogenous BCAT1 (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "performed", "in", ...
PMC9684669	However, the mechanism underlying aberrant ABCB1 expression remains unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "mechanism", "underlying", "aberrant", "ABCB1", "expression", "remains", "...
PMC11412752	Upon sensing bacterial DNA, STING can activate the production of interferons, which initiates an antiviral response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "sensing", "bacterial", "DNA", ...
PMC11572213	GLUL mRNA expression was investigated using quantitative reverse transcription polymerase chain reaction and protein levels were evaluated using immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GLUL", "mRNA", "expression", "was...
PMC11228511	The fact that progerin triggered NM ruptures in SMCs (but not in adjacent endothelial cells or adventitial cells) helped to explain the histopathologic hallmark in HGPS (loss of medial SMCs in large arteries) (26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	c DNA synthesis was examined in cells stably expressing vector and cells stably expressing BRD4 using BrdU/PI assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "c", "DNA", "synthesis", "was", "examin...
PMC7709199	Crystallization of the CSF-1–CSF-1RD1–D3 complex has previously been reported (Felix et al., 2015 ▸).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Crystallization", "of", "the", "CSF-1–CSF-1RD1–D3", ...
PMC10502403	Metabolites involved in the TCA cycle and OXPHOS were strongly correlated with PC1, which separated unstimulated NE1-GMCs from unstimulated NGMCs (Figure 3B and Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	Error bars represent the median absolute deviation percentile (MADP) of the average.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "median", "absolute", "deviation",...
PMC11473843	After expansion of the single cell clones, genomic DNA was isolated and a PCR of the sgRNA target region was performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "exp...
PMC11129910	It could lead to the loss of function of tumor suppressor genes at this location and in the nearby regions on chromosome 22 that could play a role in tumor development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	ANOVA analysis of variance, BCTC N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine-1(2H)-carboxamide, CAP capsaicin, CHO K1 Chinese hamster ovary, GLP-1 glucagon-like peptide-1, S.E.M. standard error of the mean, TRPV1 transient receptor potential vanilloid 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	We questioned whether terfenadine impacts the expression or function of ABCB1 in these MDR ovarian cancer cells, as ABCB1 overexpression was essential for the chemoresistance of A2780-ADR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	In brief, 24-well plates were used to dispense 500 µl per well of agar 0.5% [1:1 v/v Low Melting Agarose (NuSieve™ GTG™, Lonza) 1% in D-PBS:DMEM - Low glucose 2x (powder, Sigma Aldrich)] as the bottom agar portion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	The cells were maintained at 37°C in an atmosphere of 5% CO2 in RPMI-1640 (Cytiva, Marlborough, MA, USA) supplemented with 15% FBS (Sigma, St. Louis, MO, USA; for BT-12), McCoy’s 5A (Corning Cellgro, Corning, NY, USA) supplemented with 10% FBS (for A-204), DMEM (Corning Cellgro) supplemented with 10% FBS (for Hs729), o...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676674	Whereas catechins, gallic acid, and derivatives of pyrogallol are the main ingredients in root extracts, labdane and methoxylated flavonoids are the most distinctive components in the aerial portions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6901583	e Conditioned media from GIST882 cells stably expressing vector or BRD4 were incubated with HUVECs cells in 96-well plates.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "e", "Conditioned", "m...
PMC11576293	Inhibiting VEGFR-2 has been regarded as a successful approach to prevent angiogenesis (Peng et al., 2017; Ceci et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11473750	After transfection, cells were harvested for total RNA or protein at 48–72 h following transfection and analysed by quantitative PCR or western blot respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11634027	Dachs was enriched at the subapical membrane in ds mutant clones (Fig. 5C), whereas Dachs levels appeared to be unaffected in ds control clones (Fig. 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682525	This suggests that hypoxic preconditioning could be a valuable strategy for enhancing the survival and adaptability of hHFSCs in a transplant scenario, making them a promising candidate for cell therapy in the context of central nervous system conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673060	Taken together, we find that 21.6% of the phosphoproteome is significantly altered upon the acquisition of secondary resistance in PazR and/or DasR sublines versus the parental A204 cells (Fig. 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10218459	To assess the influence of the combination therapy with the cytostatics and CPP on cell growth, cells from each cell line were treated with both CPP and cytostatics and incubated for 120 h. After 4, 24, 48, 72, 96, and 120 h, the number of living cells was determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Pharmacokinetic analyses showed a significant increase in ara-CTP levels (1.5-fold; P=0.04) in the 6 patients receiving single doses of 1000 mg hydroxyurea.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	After first-line treatment, 54% were chemotherapy refractory, 21% relapsed within 12 months, and 25% relapsed after 12 months; 51% of patients received bridging chemotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Indeed, incubation of complexes with pDNA leads to DNA damage (single-strand cleavage) due to an oxidative mechanism that is clearly dependent on single oxygen, particularly for complex 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938377	Cells were seeded in flat-bottomed 96-well plates as a suspension in a prepared medium (100 μL aliquots and approximately 4300 cells per well) and preincubated for 24 h. Stock solutions of compounds were prepared in MilliQ water and sequentially diluted in the appropriate medium to give a final compound concentration r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6643347	As shown in Table 1, almost the same concentration of SBF-HS was sufficient to suppress an HIV infection induced by X4 strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", ...
PMC9019892	In this study, through high‐throughput screening using a functional isogenic BaF3 cell library, we found that nintedanib, a triple angiokinase inhibitor of FGFR/VEGFR/PDGFR that has been approved for the treatment of IPF and NSCLC, exhibited potent activity against a panel of primary gain‐of‐function (GOF) mutations an...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964635	Compounds 7a (2.46%), 7b (4.43%), 7c (4.32%), 7e (4.19%), and 7d (7.33%) also exhibited low cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	Read counts of each sample were normalized with DESeq and ran a negative binomial two sample test to find significant genes in higher transcript abundance in either sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	These low agreements make the integration process harder, since there are no shared patterns of interactions across the networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "low", "agreements",...
PMC11678130	Moreover, a significant increase in the apoptotic index compared to the control was obtained for 5-FU (5 µM and 10 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5673060	Enrichment analysis was performed using DAVID Bioinformatics Resources 6.8 with human genome as a background dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enrichment", "analysis", "was", "performed", "using", ...
PMC11469524	Moreover, the BL-2 network was also suited to model BCR signaling in Diffuse large B cell lymphoma cells lines with aberrant BCR signaling (HBL-1, OCI-LY3), indicating that BCR aberration does not cause a major downstream rewiring.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6133382	After incubation and washing, PG9 was added in a range from 10 μg/mL to 0.0001 μg/mL and then incubated at 25 °C for 90 minutes with shaking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11694625	20 Female Blab/c mice (age 6 weeks) of SPF grade were obtained from Changsheng Biotechnology Co., Ltd (SCXK 2020-0001).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7433824	Recently, it has been shown that P4 is more effective than conventional steroids to alleviate brain tumor edema and prolongs survival in rats with orthotopic GBM allografts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11089031	The mean survival time was 54.17 months in the low-expression group (lower quartile) compared to 31.53 months in the high-expression group (upper quartile).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502327	At the same time, the change of pathological microenvironment can reduce the kidney clearance rate of drugs, so that therapeutic drugs can enter and stay in tumor tissues (163).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Pts received a median of 4 (range 1–14) cycles of CC-95251.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "received", "a", "median", "of", "4", "(", "range", "1–14", ...
PMC9429973	The transcriptomic landscape of differentiated IPSCs was explored using single-cell RNA sequencing and downstream computational analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcriptomic", "landscape", "of", "differentiated",...
PMC11706491	At the end of the G1 phase, cells decide whether to commit to a new cell cycle in a pivotal event known as START in yeast or the Restriction Point in higher eukaryotes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9479186	The remaining 31 nDNA-encoded subunits are called “redundant” subunits and most of them do not participate in the enzymatic activity of Complex I, and their actual function is still unknown (24–26).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Despite therapeutic advances, there are no approved treatments for relapse disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "therapeutic", "advances", ",", "there", "are", "no", "approved", "tre...
PMC11683240	These residues are mainly involved in interaction with residues from S3 either by polar (Q44 and S45) or nonpolar (S301 and Q305) interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6102174	The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structures", "of", "the", "new", "compounds", "were"...
PMC10114490	p < 0.05.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "." ] } ]
PMC9429973	Understanding the spectrum of genetic causes of neutropenia in ethnically diverse populations and the related clinical presentation may direct the molecular work-up and clinical care.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11438317	Although LYP function has been primarily studied in T cell activation upon TCR engagement, its function has been extended to other receptors in these cells, including the LFA-1 integrin , and to B lymphocytes , where it regulates BCR induced signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Data from Part 1 will help determine the optimal dose of bezuclastinib, which will be utilized to further assess safety, efficacy, PK, and PD in Part 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	In this work, the group evaluated, in vitro, the effects of a nutraceutical antioxidant, apigenin, in ES cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC10040136	Anti-CD90 positive MACS purified MSC from tumor tissue, and the cells obtained after adherent culture had a typical spindle and stellate morphology (A) with the characteristic tri-lineage differentiation ability of MSC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9727330	Thus targeting Asp by asparaginase is affected in cancer therapy; however, ASNS expression was linked to the asparaginase-resistant mechanism during therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ...
PMC11240448	A complete description of the BMRA network reconstruction algorithm is given in Ref. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "description", "of", "the", "BMRA", "network", "...
PMC11752767	A recent clinical study using TCR-T cells targeting HPV-16 E7 antigen in HPV-16+ epithelial cancers showed that resistance to T cell therapies involved several actors of the antigen presentation process and of the interferon pathway, with a patient demonstrating loss of TAP1, TAP2, and IFNGR .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329237	Next, the cells were treated with various concentrations of BLM (0.05 to 0.5 µg/ml), PFD (0.025 to 0.5 mM), and LOS (0.05 to 1 mM) alone for 48 hr to determine the non-toxic concentrations of compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11119602	The interactive residues were arranged in short linear motifs comprising 3–6 amino acids, which are likely to engage in specific, but transient interactions with TG2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10197932	As a control, healthy lymphocytes were grown, after US treatment, in the same condition and in presence of CD3/CD28 activation beads (which can activate proliferation in resting lymphocytes), and the growth was followed up for 6 days (Figure 3A and Figure 3B, right panels).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9727330	A and B) The pharmacophore mapping snapshot indicates the possible hydrophobic interaction and binding affinity between Asp, NNDAsp, respectively, and the ASNS chain protein crystal structure Quantification Analysis of P53, and Casp3 Gene Expression in Caco-2-Treated Cells Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11680562

The finding is substantiated by the persistent existence of unique peaks in all spectra, suggesting the drug's compatibility with the other components in the PXFCu anticancer gel.

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PMC9105697

Quantification of ctDNA is challenging, as minute amounts of mutated DNA fragments have to be detected in a large background of unmutated DNA.

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PMC9429973

Results: Summary/Conclusion: Hematological complications commonly reported following COVID-19 vaccination were thrombosis with thrombocytopenia syndrome following AstraZeneca vaccination.

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PMC6487404

The tested inhibitors caused a 2.6 to 3-fold increase in the REG permeability (P < 0.01).

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PMC10745221

The HCT116 and HeLa cells showed a very similar banding pattern with both the SDMA and ADMA antibodies.

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PMC9398137

These data support the hypothesis that occupational status of MCL1 protein belong to the key factors predicting sensitivity to S63845.

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PMC9111184

In fact, in presence of cholesterol, all tested compounds could permeate the Caco-2 monolayer with a percentage ranging from 7.72 to 14.15 and a Papp values between 1.34 and 2.45 10− cm s (Table 2).

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PMC11787355

The TCR was comprehensively examined in vitro and in vivo for its anti-tumor activity against experimental flank and brain tumors, primary glioblastoma cell lines, and IPTOs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6267596

Of the up-regulated genes, 11 genes are involved in DNA repair (EXO1, CLSPN, XRCC3, NABP2, XRCC2, FANCD2, TREX2, TDG, MUS81, MTOR, POLQ), all of which showed a ≥2-fold increase in expression (shown in red squares).

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PMC11257988

It is generally believed that the difficulty in developing direct KRAS inhibitors is due in part to the pico-molar affinity of GTP and GDP for KRAS (which have much higher cellular concentrations) and to the lack of suitable deep pockets for conformational regulation .

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PMC10759659

Therefore, we have mainly focused on HBV-HCC in the current study.

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PMC11621565

Although a pathogen has not been identified, this hypothesis points out the notable role of the gastrointestinal tract and nasal cavity in the initiation of α-synuclein aggregation.

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PMC9370419

In HBV infection, our findings may serve as an exploration of the anti-HBV molecular mechanism.

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PMC6948907

1998; Grignani et al., 1998; Lin et al., 1998).

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PMC9429973

Methods: BCL2 and MYC protein expression were assessed by IHC and identified as IHC+ (≥50% [BCL2]/≥40% [MYC]) or IHC−; MYC-R, BCL2-R, and BCL6-R were detected by fluorescence in situ hybridization (Tilly et al. NEJM 2022).

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PMC11295144

Data from n = 31 α2β3γ2-GABAAR/NL2-, n = 32 α2β3δγ2ICL-GABAAR/NL2-, and n = 30 α2β3δ-GABAAR/NL2-expressing HEK293 cells, from N = 2 independent experiments.

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PMC10335954

Early DNA damage to gastric mucosa leads to an increase in NF-κB expression, which subsequently promotes the release of inflammatory mediators in the cancer tissue compared with adjacent normal mucosa of stomach cancer (Yin et al. 2013).

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PMC11539788

E-H) western blot analyses of ILK protein levels in BCa cells with stable overexpression or knockdown of RNF19A and quantitative analyses. (

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PMC9587298

On the other hand, no significant changes in the amount of cyanidin-3,5-diglucoside and cyanidin-3-sambubioside-5-glucoside were observed, suggesting that under the conditions used in this work, diglycosylated anthocyanins do not trap MGO (Fig. 1c).

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PMC11806182

UCEC is characterized by a wide range of molecular and genetic alterations .

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PMC8728081

The rate of temperature increase was 10 °C/min.

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PMC11144200

Furthermore, these liposomes endocytosed into tumor cells and accumulate in the tumor tissue after administration, followed by inhibition of tumor cells DNA synthesis and strong induction apoptosis through the release of DOX.Fig.

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PMC9429973

As we do not know if the GWAS-identified SNPs are the causal variants or just markers of risk, the functional characterization of the causal risk variants would lead to a better understanding of disease development.

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PMC10237474

The full MS scan was acquired over the m/z range 500–3500.

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PMC11422150

This study evaluates the therapeutic potential of intravenously administered hAMSCs in SCI models.

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PMC6600592

Colorless liquid, yield 81.7%.

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PMC11543935

Fiber-like structures occur throughout this segment marked with a yellow arrow.

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PMC11718274

This effect is primarily attributed to the generation of excessive reactive oxygen species (ROS), which ultimately disrupts mitochondrial membrane integrity, induces DNA damage and oxidative stress triggering apoptosis.

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PMC6642070

Statins have been reported to increase phosphorylation of MDM2 at Ser166, which can promote p53 degradation .

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PMC7504302

The only frontline chemotherapy regimen approved for clinical use in advanced stage MPM is the combination of platin and pemetrexed.

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PMC7351993

When the FSC signal intensity exceeds a predetermined threshold, the TM node generates a trigger signal for the DA node array to initiate SRS image acquisition as well as for the TM node internally to initiate the calculation of the sort time with the predetermined sort latency.

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PMC11790599

The scale bar is 10 μm.

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PMC9341513

Healthy cells.

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PMC11562028

It showed that the regulating trends of the nine genes (COL6A3, ITGA1, ITGB6, PTK2, PIK3CA, AKT3, CDKN1A, CDK2 and CCNA2) verified by the qPCR were consistent with the transcriptome test data (Fig. 5A).

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PMC11786600

In short, PED2 and PED4 exhibited optimal fiber micromorphology when the PF-127 content was 15%.

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PMC11122631

This subfraction was further purified by reverse-phase HPLC (phenyl-hexyl column) eluted with 50% acetonitrile, and compound 2 (0.6 mg) was obtained.

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PMC11286266

Considering the crucial role of trafficking in ATF6α activation, we next investigated whether depletion of CRT affected the stress-induced localisation of ATF6α by comparing the subcellular localisation of ATF6α in parental and CRT∆ cells.

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PMC11637276

Media was changed after 6 h. After 48 h, cells were selected with 2 μg/ml blasticidin.

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PMC4659567

A fluorescence spectrum of free 5Faza is inserted.

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PMC11188874

C, Effect of HDAC6 inhibitors on CTL-mediated tumor lysis.

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PMC11676169

This was performed in CUTLL1 T-ALL cells that express undetectable levels of endogenous BCAT1 (Figure 2A).

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PMC9684669

However, the mechanism underlying aberrant ABCB1 expression remains unknown.

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PMC11412752

Upon sensing bacterial DNA, STING can activate the production of interferons, which initiates an antiviral response .

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PMC11572213

GLUL mRNA expression was investigated using quantitative reverse transcription polymerase chain reaction and protein levels were evaluated using immunoblotting.

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PMC11228511

The fact that progerin triggered NM ruptures in SMCs (but not in adjacent endothelial cells or adventitial cells) helped to explain the histopathologic hallmark in HGPS (loss of medial SMCs in large arteries) (26).

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PMC6901583

c DNA synthesis was examined in cells stably expressing vector and cells stably expressing BRD4 using BrdU/PI assays.

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PMC7709199

Crystallization of the CSF-1–CSF-1RD1–D3 complex has previously been reported (Felix et al., 2015 ▸).

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PMC10502403

Metabolites involved in the TCA cycle and OXPHOS were strongly correlated with PC1, which separated unstimulated NE1-GMCs from unstimulated NGMCs (Figure 3B and Table S2).

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PMC11188874

Error bars represent the median absolute deviation percentile (MADP) of the average.

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PMC11473843

After expansion of the single cell clones, genomic DNA was isolated and a PCR of the sgRNA target region was performed.

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PMC11129910

It could lead to the loss of function of tumor suppressor genes at this location and in the nearby regions on chromosome 22 that could play a role in tumor development.

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PMC11612315

ANOVA analysis of variance, BCTC N-(4-tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl) tetrahydropyrazine-1(2H)-carboxamide, CAP capsaicin, CHO K1 Chinese hamster ovary, GLP-1 glucagon-like peptide-1, S.E.M. standard error of the mean, TRPV1 transient receptor potential vanilloid 1.

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PMC9684669

We questioned whether terfenadine impacts the expression or function of ABCB1 in these MDR ovarian cancer cells, as ABCB1 overexpression was essential for the chemoresistance of A2780-ADR.

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PMC10698968

In brief, 24-well plates were used to dispense 500 µl per well of agar 0.5% [1:1 v/v Low Melting Agarose (NuSieve™ GTG™, Lonza) 1% in D-PBS:DMEM - Low glucose 2x (powder, Sigma Aldrich)] as the bottom agar portion.

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PMC11185260

The cells were maintained at 37°C in an atmosphere of 5% CO2 in RPMI-1640 (Cytiva, Marlborough, MA, USA) supplemented with 15% FBS (Sigma, St. Louis, MO, USA; for BT-12), McCoy’s 5A (Corning Cellgro, Corning, NY, USA) supplemented with 10% FBS (for A-204), DMEM (Corning Cellgro) supplemented with 10% FBS (for Hs729), o...

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PMC11676674

Whereas catechins, gallic acid, and derivatives of pyrogallol are the main ingredients in root extracts, labdane and methoxylated flavonoids are the most distinctive components in the aerial portions .

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PMC6901583

e Conditioned media from GIST882 cells stably expressing vector or BRD4 were incubated with HUVECs cells in 96-well plates.

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PMC11576293

Inhibiting VEGFR-2 has been regarded as a successful approach to prevent angiogenesis (Peng et al., 2017; Ceci et al., 2020).

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PMC11473750

After transfection, cells were harvested for total RNA or protein at 48–72 h following transfection and analysed by quantitative PCR or western blot respectively.

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PMC11634027

Dachs was enriched at the subapical membrane in ds mutant clones (Fig. 5C), whereas Dachs levels appeared to be unaffected in ds control clones (Fig. 5A).

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PMC11682525

This suggests that hypoxic preconditioning could be a valuable strategy for enhancing the survival and adaptability of hHFSCs in a transplant scenario, making them a promising candidate for cell therapy in the context of central nervous system conditions.

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PMC5673060

Taken together, we find that 21.6% of the phosphoproteome is significantly altered upon the acquisition of secondary resistance in PazR and/or DasR sublines versus the parental A204 cells (Fig. 6B).

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PMC10218459

To assess the influence of the combination therapy with the cytostatics and CPP on cell growth, cells from each cell line were treated with both CPP and cytostatics and incubated for 120 h. After 4, 24, 48, 72, 96, and 120 h, the number of living cells was determined.

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PMC9429973

Pharmacokinetic analyses showed a significant increase in ara-CTP levels (1.5-fold; P=0.04) in the 6 patients receiving single doses of 1000 mg hydroxyurea.

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PMC9429973

After first-line treatment, 54% were chemotherapy refractory, 21% relapsed within 12 months, and 25% relapsed after 12 months; 51% of patients received bridging chemotherapy.

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PMC10988555

Indeed, incubation of complexes with pDNA leads to DNA damage (single-strand cleavage) due to an oxidative mechanism that is clearly dependent on single oxygen, particularly for complex 3.

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PMC10938377

Cells were seeded in flat-bottomed 96-well plates as a suspension in a prepared medium (100 μL aliquots and approximately 4300 cells per well) and preincubated for 24 h. Stock solutions of compounds were prepared in MilliQ water and sequentially diluted in the appropriate medium to give a final compound concentration r...

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PMC6643347

As shown in Table 1, almost the same concentration of SBF-HS was sufficient to suppress an HIV infection induced by X4 strains.

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PMC9019892

In this study, through high‐throughput screening using a functional isogenic BaF3 cell library, we found that nintedanib, a triple angiokinase inhibitor of FGFR/VEGFR/PDGFR that has been approved for the treatment of IPF and NSCLC, exhibited potent activity against a panel of primary gain‐of‐function (GOF) mutations an...

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PMC9964635

Compounds 7a (2.46%), 7b (4.43%), 7c (4.32%), 7e (4.19%), and 7d (7.33%) also exhibited low cytotoxicity.

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PMC9684669

Read counts of each sample were normalized with DESeq and ran a negative binomial two sample test to find significant genes in higher transcript abundance in either sample.

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PMC6379402

These low agreements make the integration process harder, since there are no shared patterns of interactions across the networks.

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PMC11678130

Moreover, a significant increase in the apoptotic index compared to the control was obtained for 5-FU (5 µM and 10 µM).

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PMC5673060

Enrichment analysis was performed using DAVID Bioinformatics Resources 6.8 with human genome as a background dataset.

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PMC11469524

Moreover, the BL-2 network was also suited to model BCR signaling in Diffuse large B cell lymphoma cells lines with aberrant BCR signaling (HBL-1, OCI-LY3), indicating that BCR aberration does not cause a major downstream rewiring.

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PMC6133382

After incubation and washing, PG9 was added in a range from 10 μg/mL to 0.0001 μg/mL and then incubated at 25 °C for 90 minutes with shaking.

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PMC11694625

20 Female Blab/c mice (age 6 weeks) of SPF grade were obtained from Changsheng Biotechnology Co., Ltd (SCXK 2020-0001).

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PMC7433824

Recently, it has been shown that P4 is more effective than conventional steroids to alleviate brain tumor edema and prolongs survival in rats with orthotopic GBM allografts.

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PMC11089031

The mean survival time was 54.17 months in the low-expression group (lower quartile) compared to 31.53 months in the high-expression group (upper quartile).

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PMC11502327

At the same time, the change of pathological microenvironment can reduce the kidney clearance rate of drugs, so that therapeutic drugs can enter and stay in tumor tissues (163).

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PMC9429973

Pts received a median of 4 (range 1–14) cycles of CC-95251.

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PMC9429973

The transcriptomic landscape of differentiated IPSCs was explored using single-cell RNA sequencing and downstream computational analysis.

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PMC11706491

At the end of the G1 phase, cells decide whether to commit to a new cell cycle in a pivotal event known as START in yeast or the Restriction Point in higher eukaryotes.

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PMC9479186

The remaining 31 nDNA-encoded subunits are called “redundant” subunits and most of them do not participate in the enzymatic activity of Complex I, and their actual function is still unknown (24–26).

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PMC9429973

Despite therapeutic advances, there are no approved treatments for relapse disease.

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PMC11683240

These residues are mainly involved in interaction with residues from S3 either by polar (Q44 and S45) or nonpolar (S301 and Q305) interactions.

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PMC6102174

The structures of the new compounds were elucidated on the basis of extensive spectroscopic analyses.

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PMC10114490

p < 0.05.

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PMC9429973

Understanding the spectrum of genetic causes of neutropenia in ethnically diverse populations and the related clinical presentation may direct the molecular work-up and clinical care.

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PMC11438317

Although LYP function has been primarily studied in T cell activation upon TCR engagement, its function has been extended to other receptors in these cells, including the LFA-1 integrin , and to B lymphocytes , where it regulates BCR induced signaling pathways.

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PMC9429973

Data from Part 1 will help determine the optimal dose of bezuclastinib, which will be utilized to further assess safety, efficacy, PK, and PD in Part 2.

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PMC10887351

In this work, the group evaluated, in vitro, the effects of a nutraceutical antioxidant, apigenin, in ES cells.

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PMC10040136

Anti-CD90 positive MACS purified MSC from tumor tissue, and the cells obtained after adherent culture had a typical spindle and stellate morphology (A) with the characteristic tri-lineage differentiation ability of MSC.

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PMC9727330

Thus targeting Asp by asparaginase is affected in cancer therapy; however, ASNS expression was linked to the asparaginase-resistant mechanism during therapy.

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PMC11240448

A complete description of the BMRA network reconstruction algorithm is given in Ref. .

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PMC11752767

A recent clinical study using TCR-T cells targeting HPV-16 E7 antigen in HPV-16+ epithelial cancers showed that resistance to T cell therapies involved several actors of the antigen presentation process and of the interferon pathway, with a patient demonstrating loss of TAP1, TAP2, and IFNGR .

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PMC10329237

Next, the cells were treated with various concentrations of BLM (0.05 to 0.5 µg/ml), PFD (0.025 to 0.5 mM), and LOS (0.05 to 1 mM) alone for 48 hr to determine the non-toxic concentrations of compounds.

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PMC11119602

The interactive residues were arranged in short linear motifs comprising 3–6 amino acids, which are likely to engage in specific, but transient interactions with TG2.

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PMC10197932

As a control, healthy lymphocytes were grown, after US treatment, in the same condition and in presence of CD3/CD28 activation beads (which can activate proliferation in resting lymphocytes), and the growth was followed up for 6 days (Figure 3A and Figure 3B, right panels).

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PMC9727330

A and B) The pharmacophore mapping snapshot indicates the possible hydrophobic interaction and binding affinity between Asp, NNDAsp, respectively, and the ASNS chain protein crystal structure Quantification Analysis of P53, and Casp3 Gene Expression in Caco-2-Treated Cells Table 2.

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