OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11679326	This paradigm limited their investigation in terms of recognition specificity that was predominantly focused on pathogen-associated molecular patterns and respective monosaccharides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "paradigm", ...
PMC11365427	It has been suggested that ATF3 is capable of exchanging with ATF4, and the activation of ATF3 is equally important during the ERS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10818062	Note that a similar cause-and-effect relationship, albeit in the opposite direction, has been observed in a PS metabolic disease, Lenz-Majewski syndrome, where the gain-of-function mutations in PTDSS1 lead to accumulation of PS at the ER (12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	This mechanism explains complete inhibition of the CENP-T-Mis12C interaction in interphase (Interphase; Figure 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "mechanism", "explains", "complete", "inhi...
PMC11486946	Scale bar, 2 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "2", "μm", "." ] } ]
PMC8345486	The other two Fe-containing derivatives (15 and 19) and unmodified ferra bis(dicarbollide) (2) also increased necrosis and late apoptosis in cisplatin-treated cells, but by half as much as compound 23 (Figure 5A, right), which showed that the conjugation of ferra bis(dicarbollide) with adenosine has an advantage over u...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197	The data presented clearly indicate that PPARα plays a crucial role in the occurrence and development of CRC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "presented", "clearly", ...
PMC11706491	Table shows mean ± standard deviation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "shows", "mean", "±", "standard", "deviation", "." ] } ]
PMC11791264	K, SETD7 OE SKOV3 cells were subjected to Western blot to test the expression of SETD7, E-cadherin, N-cadherin, Vimentin, and Snail, taking α-tubulin as an internal reference.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9065483	Samples were washed twice with cold PBS and lysed for 10 min at 4°C using 50 mM HEPES, 150 mM NaCl, 10 mM EDTA, 10 mM Na4P2O7, 100 mM NaF, 2 mM Na3VO4, protease inhibitor cocktail (Roche), phosphatase inhibitor cocktail (Cell Signaling Technology, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730320	The gating strategy employed is shown in Supplementary Fig. S7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "employed", "is", "shown", "in", "Supplementary", "Fig.", "S7", ...
PMC11725127	These results were consistent with the analysis of primary samples collected in this study (Fig. 6H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "were", "consistent", ...
PMC11750161	However, all receptor mutants showed effective response to the rec-eCG agonist treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "all", "receptor", "mutants", "showed", "effective", "respon...
PMC6450504	The cell cycle distribution was analyzed by LSC (Figure 4(c–f) and Supplementary Figure S2), which combines the advantages of flow cytometry with the ability to evaluate cell morphology and quantification of cell components depending on the different fluorescent dyes utilized in the assay (Luther et al., 2004).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9926039	Water molecules, crystallized with targets, were removed to generate an original crystalline structure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Water", "molecules", ",", "crystallized", "with", "targets", ...
PMC11590870	Furthermore, all MOP tested doses had no adverse effect on CCD18-Co cells’ viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "all", "MOP", "tested", "doses", ...
PMC11783017	After exposure to GSH, the release rate of cisplatin reached 60.7 ± 7.7 %, whereas under the condition without GSH, the release rate was only 28.1 ± 1.7 %.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11720107	Absorbance measurements were taken at 405 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Absorbance", "measurements", "were", "taken", "at", "405", "nm", "." ] } ]
PMC11551844	The eluent (10–15 mL) was collected in test tubes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "eluent", "(", "10–15", "mL", ")", "was", "collected", "in", "test", "tub...
PMC5173112	Invaded cells were stained with the HEMA-3 kit (Fisher) after 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Invaded", "cells", "were", "stained", "with", "the", "HEMA-3", "...
PMC9429973	After LD chemotherapy, PHE885 will be infused (in the outpatient or inpatient setting per physician discretion) as a single dose of 5.0×10 (range, 4×10 to 5×10) CAR-positive viable T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median time from diagnosis to the start of 2L Tx was 33.3 months, increasing from 31.8 months in the 2012-15 cohort to 40.2 months in the 2019-20 cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Indeed, abnormalities in the T-cell compartment have been described many years ago although their role role in supporting or controlling leukemic cells is still unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11730311	Cells were then incubated for 30 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "incubated", "for", "30", "min", "at", "room", "temperature", "." ...
PMC11755624	It also enhanced the process of intracellular degradation and quality control known as autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "enhanced", "the", "process", "of", "intracellular", ...
PMC10589262	No significant association between KIT mutation and ATF6 expression was observed (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "association", "between", "KIT", "...
PMC11026382	Mutants with fewer than 10 counts were considered absent from the data set and were set to zero to reduce noise.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutants", "with", ...
PMC9275501	The results showed that HA-coated liposomes were more effective, and CBX and SIL showed a synergistic effect on prostate cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", ...
PMC9693627	We performed a Western blot analysis with the antibodies to both of them to find out which one was affected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "a", ...
PMC11457557	Several essential genes involved in lipid production or metabolism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "essential", "genes", "involved", "in", "lipid", "production", "or", "metabolism", "." ] } ...
PMC9429973	Adult patients with RRMM who had received at least two kinds of therapy, including bortezomib, lenalidomide or thalidomide, are enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adult",...
PMC11033180	ENS, enteric neuron cultures and gut explants were fixed with 4% PFA for 5 min and permeabilized in PBS containing 0.25% Triton X-100 for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9780037	The cyt c therapeutic delivery systems may become more widely available if their thermal stability could be extended.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cyt", "c", "therapeutic", "deli...
PMC11453690	With novel processing techniques being developed to increase fat graft retention, there is a need to better understand how these will affect the biology of lipoaspirates for women who have previously had breast cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509278	In an untargeted metabolomics study of ovarian cancer SKOV3 cells, B-norcholesterol benzimidazole compounds inhibited the intracellular metabolism and protein synthesis and decreased the energy metabolism of SKOV3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	As SS18–SSX-mediated synovial sarcomagenesis is robustly recapitulated in the mouse (27, 28), we determined to test this model through the impact of genetic manipulation of Smarcb1 on the characteristic synovial sarcoma tissue phenotypes, and to follow-up our results with genomic, molecular, and biochemical assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Despite intensive multi-modal therapy, the prognosis for high-risk patients remains poor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "intensive", "multi-modal", "therapy", ",", "the", "prognosis", "for", ...
PMC11544771	In addition, the anticancer potential of PRE has also been described in lung cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "anticancer", "potential", "of...
PMC2777936	The cycle at which fluorescence exceeded a defined threshold (CT score) in this analysis varied widely for Wnt ligands with most being barely detected (i.e. CT score greater than 30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11180402	Moreover, overexpression of SNHG1 is sufficient to drive malignant transformation of normal human urothelial cells and promotes tumorigenicity of human BMIBC in nude mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ],...
PMC7961460	The PCR program consisted of an initial hot start at 50 °C for 2 min, followed by 95 °C for 10 min and 45 amplification cycles (95 °C for 15 s and 60 °C for 60 s).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9386809	Calix[n]arenes (n = 4, 5, 6, 8), due to their shape and host–guest binding capabilities, have found numerous applications in molecular recognition, self-assembly, drug delivery, and catalysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791203	Some chemotherapy drugs induce cancer cell death via a p53 dependent pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "chemotherapy", "drugs", "induce", "cancer", "cell", "death", "via", "a",...
PMC9046263	A summary of overlapping DEGs and their functions are also shown in Supplementary Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "summary", "of", "overlapping", "DEGs", "and", "their",...
PMC9429973	Summary/Conclusion: This is the first study focused on examining the lncRNA GAS5 and miR-222 expression pattern in AML patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "T...
PMC11507371	CAP’s efficiency to induce apoptosis in malignant cells is particularly noteworthy since the evasion of cell death, a fundamental hallmark of cancer cells, represents a great challenge in cancer therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10808409	Statistical analysis of the D-optimal design showed significant models for both the EE% and the PS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "the", "D-optimal", "d...
PMC11599565	This process was repeated until approximately 20 cells were picked.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "was", "repeated", "until", "approximately", "20", "cells", "were", "picked", ...
PMC11474209	Additional research is underway to develop mitigation techniques for managing MC-LR pollution in drinking water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "research", "is", "underway", "to", "develop", ...
PMC11761919	One tube from each group was selected at seven time points 0, 30, 60, 90, 120, 150, and 180 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	The neutrophil recovery was on day 11 (9-19) for the first and on day 11 (9-18) for the second group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11319300	Intriguingly, this scenario concurrently activates MYEOV, as evidenced by the appearance of active promoter-associated marks (an H3K4me3 broad domain) over the MYEOV’s gene body (Mikulasova et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587298	Briefly, 1 g of freeze-dried elderberries were extracted eight times with acidified methanol (1 % HCl).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "1", "g", "o...
PMC11474209	The eradication of intracellular cyanotoxins (intact cells) can be achieved through various methods, including pre-treatment oxidation, coagulation/sedimentation/filtration, and membrane filtration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11707577	In contrast, upon irradiation with visible LED light, even at an ultralow light dose, M13EGFR(TNP) demonstrated excellent performances in PDT, with a killing activity at picomolar concentrations (IC50 = 160 pm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683130	SerpinB5, as an autoantigen of an autoimmune response induced by streptococcus, is the target of an enhanced T-cell response in psoriasis (79).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11754291	The AlamarBlue assay revealed that cytotoxicity was only evident at the highest blue light intensity (50 mW/cm, 50 J/cm) and UVA exposure, with UVA having the most pronounced effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The same results were observed in the cohort defined by ELN criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "results", "were", "observed", "in", "the", "cohort", "defined", ...
PMC11502327	Due to the low bioavailability and short half-life of DOX, the key is that effective treatment often requires high drug doses, which often lead to an increase in side effects such as nephrotoxicity and cardiotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11040965	Briefly, DNA was extracted from U266 cells (3 × 10 per sample) and from plasma cells of MGUS (from 1 × 10 to 3 × 10) and MM (from 3.8 × 10 to 7 × 10) patients using the PureLink Genomic DNA purification kit (Thermo Fisher Scientific, # K182001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Fatigue was the most negatively impactful symptom for 55% of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fatigue", "was", "the", "most", "negatively", "impactful", "symptom", "for", "55...
PMC9429973	We next used phosphoproteomics to explore the signaling consequences of DUSP1/6 inhibition in CLL, and discovered that DUSP1/6 inhibition caused acute stimulation of BCR/MAPK signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11723947	b, c Percentage of WT or HP1γ KO TCR Vβ6 Tconv producing IFN-γ (b) or IL-17A (c) 21 days after engraftment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC3675084	Our study shows that mitotic response pathways are highly deregulated in the OVCAR-3-TR and SKOV-3-TR cancer cells, evidenced by down-regulation of cyclin B1, depletion of mitotic spindle checkpoint protein BubR1, and inability to activate mitotic epitope MPM-2 in resistant cells when compared with the parental cells (...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10820104	The subsequent prenylation cascade of echinulin and neoechinulin series of alkaloids in Aspergillus ruber has been demonstrated to be mediated via two prenyltransferases, EchPT1 and EchPT2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10297204	Electrophysiological signals were acquired using a NICOLET VIKING SELECT electromyography machine (Natus Neurology Inc., Middleton, WI, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrophysiologic...
PMC9429973	Methods: Single-center, retrospective study with 219 patients with SCD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Single-center", ",", "retrospective", "study", "with", "219", "patients", ...
PMC11578343	Zone lengths greater than 6 mm was not possible to test, given that the total “footprint” of the mz‐visco‐NPS channel would have surpassed the physical length of the glass substrate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Source data We therefore investigated whether functional deficits were present, which would provide insight into the early brain changes in FTD and ALS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7812570	The cotransfected cells were collected to analyze the cell-surface expression of GPI-anchored antibodies by FACS with an anti-His antibody as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cotra...
PMC9429973	p=0.01; TCF3-PBX1 - 94.1% MRD neg.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p=0.01", ";", "TCF3-PBX1", "-", "94.1", "%", "MRD", "neg", ".", "," ] } ]
PMC10114490	The strategy envisaged in this report allows, at a reduced time and cost expenses, the generation of an unlimited source of clonal, homogeneous, non-transformed hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11317131	By overcoming the lack of efficiency of current methods, numerous applications would be accelerated, including (i) integration into genomes of cell lines used in industrial biotechnology for the production of pharmaceuticals and other proteins (6); (ii) introduction of desirable traits, such as disease resistance or en...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	It is noteworthy that QUE exhibits this effect at a low concentration (2 µM), which is less than 10% of its IC50 growth-inhibitory concentration, as determined by averaging eight different cancer cell lines (the mouse melanoma cancer cell line, human non-small cell lung cancer, glioblastoma, colon cancer, breast and pr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10411253	The Arg312 of AMH is indicated in a black box. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Arg312", "of", "AMH", "is", "indicated", "in", "a", "black", "box", ".",...
PMC9429973	Previously, we described the incidence and outcomes of CMML at the population level (2004-2015) using the Surveillance, Epidemiology, and End Results Program (SEER) and National Cancer Database (NCDB) (Ruan et al., ASH 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The last one is still on treatment (after 2 months).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "last", "one", "is", "still", "on", "treatment", "(", "after", "2", ...
PMC11578343	Additionally, we identify viscoelastic differences among single cells from three different breast epithelial cell lines, MCF‐10A, MCF‐7, and MDA‐MB‐231.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O" ], ...
PMC5963610	Clinical response to Nimotuzumab and NGcGM3/VSSP vaccine by the sequential computed tomography during 122 months (A-E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "response", "to", "Nimotuzumab", ...
PMC7917457	B16-OVA, a mouse melanoma cell line expressing chicken OVA, was kindly provided by Professor Richard Vile (Mayo Clinic, Rochester, MN, USA).	[ { "tags": [ "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11509309	Pseudoceratinine A (3) showed no activity against PrP up to 20 µM. Pseudoceratinine B (6) was also inactive up to 10 µM and was cytotoxic at concentrations above 10 µM. Aerophobin-2 (4), which was used as a negative control as it was inactive against both [PSI+] and [URE3] yeast prions (Figure 3), was not active up to ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2614415	It is also important to note that as the concentrations of VE-465 increased, both cell lines became increasingly aneuploid (data not shown).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9919300	Curcumin and andrographolide were dissolved in 100% DMSO as stock solutions and further diluted with bidistilled water (dH2O) to a desired concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11756514	Samples prepared in spectrophotometer cuvettes included 400 µL of the bacterial suspension and 100 µL SP-D (to a final concentration of 1 µg/mL) or a control with no SP-D. OD650 was measured at the start of incubation and again after 16 h of incubation at 4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In most cases, neither histological/immunohistochemical examination, nor PCR methods for determining clonality give a definite conclusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "most", "cases", ",", "neither", ...
PMC11763126	A Colony formation assay showing RCC cell proliferation after different treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Colony", "formation", "assay", "showing", "RCC", "cell", "proliferation", "after", ...
PMC11461833	Notably, the most significant activation of HERVH-int was obversed in the STXBP5 OE group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "most", "significant", "activation", ...
PMC11463018	H NMR (500 MHz, Chloroform-d) δ: 8.01 − 7.97 (m, 2H), 7.91 − 7.86 (m, 2H), 7.47 − 7.40 (m, 3H), 7.37 − 7.34 (m, 1H), 7.17 (t, J = 8.6 Hz, 2H), 6.88 − 6.84 (m, 1H), 5.16 (t, J = 6.4 Hz, 1H), 4.66 (d, J = 6.1 Hz, 2H), 3.90 (s, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7802142	n ≥ 3; P < 0.05, *P < 0.01, n.s.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "≥", "3", ";", "*", "P", "<", ...
PMC11045125	Colonies bearing the appropriate insert were identified by EcoRI digest of Qiaprep Miniprep Kit (Qiagen) DNA and submitted for sequencing by GeneWiz (Burlington, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	Lethally-irradiated B6 mice were grafted with a 1:1 mixture of B6 and B6D2F1 bone marrow and co-injected with WT or HP1α-deficient naive CD4 T cells alone or in the presence of ex vivo expanded WT Treg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502443	Mouse models deficient in RAMP1 and RAMP3 display enhanced body weight reduction in response to both GIP and GLP-1 (Leuthardt et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10656496	Cells were then plated on Greiner 96-well U-bottom, Cellstar® cell-repellent plates (Greiner Bio-One, Kremsmünster, Austria) using 3.5% Matrigel (Corning, Inc., Corning, MA) to form spheroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11064533	The strain was tested in multiple media to rule out media or synthetic/plastic surfaces, influencing clump formation as the strain strictly formed these structures on the epithelial cells and most prominently on the human urinary bladder cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	Results showed that the effects of BMS on inhibiting fat accumulation was diminished in the daf-16 mutant, concomitant with the abrogation of lifespan extension (Fig. 4A and D, Table 1), hinting daf-16 was required in the BMS′ fat-lowering and lifespan prolongation functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629461	Each data dot on the bar column represents one cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "data", "dot", "on", "the", "bar", "column", "represents", "one", "cell", "." ]...
PMC11803918	Melanoma is one of the most aggressive types of skin cancer, with high rates of metastasis and poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Melanoma", "is", "one", ...
PMC7602170	The mTOR pathway is activated in PDGFRA mutated and wt GISTs, which suggests that mTOR or upstream mTOR inhibitors may be potential therapeutic targets for primary resistant GISTs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11738017	Similarly, for elranatamab at the recommended phase 2 fixed dosing of 76 mg, a higher baseline level of sBCMA (≥144 ng/mL) led to a lower probability of an objective response (Figure 44 of the New Drug Application and Biologic License Application document).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9676986	This steady growth is because the efficacy of FGFR inhibitors is low, and clinical responses to the agents are inconsistent (Katoh, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11679326

This paradigm limited their investigation in terms of recognition specificity that was predominantly focused on pathogen-associated molecular patterns and respective monosaccharides.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "paradigm", ...

PMC11365427

It has been suggested that ATF3 is capable of exchanging with ATF4, and the activation of ATF3 is equally important during the ERS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10818062

Note that a similar cause-and-effect relationship, albeit in the opposite direction, has been observed in a PS metabolic disease, Lenz-Majewski syndrome, where the gain-of-function mutations in PTDSS1 lead to accumulation of PS at the ER (12).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612794

This mechanism explains complete inhibition of the CENP-T-Mis12C interaction in interphase (Interphase; Figure 7).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "mechanism", "explains", "complete", "inhi...

PMC11486946

Scale bar, 2 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "2", "μm", "." ] } ]

PMC8345486

The other two Fe-containing derivatives (15 and 19) and unmodified ferra bis(dicarbollide) (2) also increased necrosis and late apoptosis in cisplatin-treated cells, but by half as much as compound 23 (Figure 5A, right), which showed that the conjugation of ferra bis(dicarbollide) with adenosine has an advantage over u...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11775197

The data presented clearly indicate that PPARα plays a crucial role in the occurrence and development of CRC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "presented", "clearly", ...

PMC11706491

Table shows mean ± standard deviation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "shows", "mean", "±", "standard", "deviation", "." ] } ]

PMC11791264

K, SETD7 OE SKOV3 cells were subjected to Western blot to test the expression of SETD7, E-cadherin, N-cadherin, Vimentin, and Snail, taking α-tubulin as an internal reference.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9065483

Samples were washed twice with cold PBS and lysed for 10 min at 4°C using 50 mM HEPES, 150 mM NaCl, 10 mM EDTA, 10 mM Na4P2O7, 100 mM NaF, 2 mM Na3VO4, protease inhibitor cocktail (Roche), phosphatase inhibitor cocktail (Cell Signaling Technology, cat.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11730320

The gating strategy employed is shown in Supplementary Fig. S7.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "employed", "is", "shown", "in", "Supplementary", "Fig.", "S7", ...

PMC11725127

These results were consistent with the analysis of primary samples collected in this study (Fig. 6H).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "were", "consistent", ...

PMC11750161

However, all receptor mutants showed effective response to the rec-eCG agonist treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "all", "receptor", "mutants", "showed", "effective", "respon...

PMC6450504

The cell cycle distribution was analyzed by LSC (Figure 4(c–f) and Supplementary Figure S2), which combines the advantages of flow cytometry with the ability to evaluate cell morphology and quantification of cell components depending on the different fluorescent dyes utilized in the assay (Luther et al., 2004).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9926039

Water molecules, crystallized with targets, were removed to generate an original crystalline structure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Water", "molecules", ",", "crystallized", "with", "targets", ...

PMC11590870

Furthermore, all MOP tested doses had no adverse effect on CCD18-Co cells’ viability.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "all", "MOP", "tested", "doses", ...

PMC11783017

After exposure to GSH, the release rate of cisplatin reached 60.7 ± 7.7 %, whereas under the condition without GSH, the release rate was only 28.1 ± 1.7 %.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11720107

Absorbance measurements were taken at 405 nm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Absorbance", "measurements", "were", "taken", "at", "405", "nm", "." ] } ]

PMC11551844

The eluent (10–15 mL) was collected in test tubes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "eluent", "(", "10–15", "mL", ")", "was", "collected", "in", "test", "tub...

PMC5173112

Invaded cells were stained with the HEMA-3 kit (Fisher) after 24 hours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Invaded", "cells", "were", "stained", "with", "the", "HEMA-3", "...

PMC9429973

After LD chemotherapy, PHE885 will be infused (in the outpatient or inpatient setting per physician discretion) as a single dose of 5.0×10 (range, 4×10 to 5×10) CAR-positive viable T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The median time from diagnosis to the start of 2L Tx was 33.3 months, increasing from 31.8 months in the 2012-15 cohort to 40.2 months in the 2019-20 cohort.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Indeed, abnormalities in the T-cell compartment have been described many years ago although their role role in supporting or controlling leukemic cells is still unclear.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11730311

Cells were then incubated for 30 min at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "incubated", "for", "30", "min", "at", "room", "temperature", "." ...

PMC11755624

It also enhanced the process of intracellular degradation and quality control known as autophagy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "enhanced", "the", "process", "of", "intracellular", ...

PMC10589262

No significant association between KIT mutation and ATF6 expression was observed (data not shown).

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PMC11026382

Mutants with fewer than 10 counts were considered absent from the data set and were set to zero to reduce noise.

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PMC9275501

The results showed that HA-coated liposomes were more effective, and CBX and SIL showed a synergistic effect on prostate cancer.

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PMC9693627

We performed a Western blot analysis with the antibodies to both of them to find out which one was affected.

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PMC11457557

Several essential genes involved in lipid production or metabolism.

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PMC9429973

Adult patients with RRMM who had received at least two kinds of therapy, including bortezomib, lenalidomide or thalidomide, are enrolled.

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PMC11033180

ENS, enteric neuron cultures and gut explants were fixed with 4% PFA for 5 min and permeabilized in PBS containing 0.25% Triton X-100 for 5 min.

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PMC9780037

The cyt c therapeutic delivery systems may become more widely available if their thermal stability could be extended.

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PMC11453690

With novel processing techniques being developed to increase fat graft retention, there is a need to better understand how these will affect the biology of lipoaspirates for women who have previously had breast cancer.

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PMC11509278

In an untargeted metabolomics study of ovarian cancer SKOV3 cells, B-norcholesterol benzimidazole compounds inhibited the intracellular metabolism and protein synthesis and decreased the energy metabolism of SKOV3 cells.

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PMC8567602

As SS18–SSX-mediated synovial sarcomagenesis is robustly recapitulated in the mouse (27, 28), we determined to test this model through the impact of genetic manipulation of Smarcb1 on the characteristic synovial sarcoma tissue phenotypes, and to follow-up our results with genomic, molecular, and biochemical assays.

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PMC11638255

Despite intensive multi-modal therapy, the prognosis for high-risk patients remains poor.

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PMC11544771

In addition, the anticancer potential of PRE has also been described in lung cancer .

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PMC2777936

The cycle at which fluorescence exceeded a defined threshold (CT score) in this analysis varied widely for Wnt ligands with most being barely detected (i.e. CT score greater than 30).

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PMC11180402

Moreover, overexpression of SNHG1 is sufficient to drive malignant transformation of normal human urothelial cells and promotes tumorigenicity of human BMIBC in nude mice .

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PMC7961460

The PCR program consisted of an initial hot start at 50 °C for 2 min, followed by 95 °C for 10 min and 45 amplification cycles (95 °C for 15 s and 60 °C for 60 s).

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PMC9386809

Calix[n]arenes (n = 4, 5, 6, 8), due to their shape and host–guest binding capabilities, have found numerous applications in molecular recognition, self-assembly, drug delivery, and catalysis.

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PMC11791203

Some chemotherapy drugs induce cancer cell death via a p53 dependent pathway.

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PMC9046263

A summary of overlapping DEGs and their functions are also shown in Supplementary Table 1.

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PMC9429973

Summary/Conclusion: This is the first study focused on examining the lncRNA GAS5 and miR-222 expression pattern in AML patients.

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PMC11507371

CAP’s efficiency to induce apoptosis in malignant cells is particularly noteworthy since the evasion of cell death, a fundamental hallmark of cancer cells, represents a great challenge in cancer therapy .

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PMC10808409

Statistical analysis of the D-optimal design showed significant models for both the EE% and the PS.

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PMC11599565

This process was repeated until approximately 20 cells were picked.

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PMC11474209

Additional research is underway to develop mitigation techniques for managing MC-LR pollution in drinking water.

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PMC11761919

One tube from each group was selected at seven time points 0, 30, 60, 90, 120, 150, and 180 min.

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PMC9429973

The neutrophil recovery was on day 11 (9-19) for the first and on day 11 (9-18) for the second group.

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PMC11319300

Intriguingly, this scenario concurrently activates MYEOV, as evidenced by the appearance of active promoter-associated marks (an H3K4me3 broad domain) over the MYEOV’s gene body (Mikulasova et al., 2022).

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PMC9587298

Briefly, 1 g of freeze-dried elderberries were extracted eight times with acidified methanol (1 % HCl).

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PMC11474209

The eradication of intracellular cyanotoxins (intact cells) can be achieved through various methods, including pre-treatment oxidation, coagulation/sedimentation/filtration, and membrane filtration .

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PMC11707577

In contrast, upon irradiation with visible LED light, even at an ultralow light dose, M13EGFR(TNP) demonstrated excellent performances in PDT, with a killing activity at picomolar concentrations (IC50 = 160 pm).

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PMC11683130

SerpinB5, as an autoantigen of an autoimmune response induced by streptococcus, is the target of an enhanced T-cell response in psoriasis (79).

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PMC11754291

The AlamarBlue assay revealed that cytotoxicity was only evident at the highest blue light intensity (50 mW/cm, 50 J/cm) and UVA exposure, with UVA having the most pronounced effect.

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PMC9429973

The same results were observed in the cohort defined by ELN criteria.

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PMC11502327

Due to the low bioavailability and short half-life of DOX, the key is that effective treatment often requires high drug doses, which often lead to an increase in side effects such as nephrotoxicity and cardiotoxicity.

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PMC11040965

Briefly, DNA was extracted from U266 cells (3 × 10 per sample) and from plasma cells of MGUS (from 1 × 10 to 3 × 10) and MM (from 3.8 × 10 to 7 × 10) patients using the PureLink Genomic DNA purification kit (Thermo Fisher Scientific, # K182001).

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PMC9429973

Fatigue was the most negatively impactful symptom for 55% of patients.

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PMC9429973

We next used phosphoproteomics to explore the signaling consequences of DUSP1/6 inhibition in CLL, and discovered that DUSP1/6 inhibition caused acute stimulation of BCR/MAPK signaling.

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PMC11723947

b, c Percentage of WT or HP1γ KO TCR Vβ6 Tconv producing IFN-γ (b) or IL-17A (c) 21 days after engraftment.

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PMC3675084

Our study shows that mitotic response pathways are highly deregulated in the OVCAR-3-TR and SKOV-3-TR cancer cells, evidenced by down-regulation of cyclin B1, depletion of mitotic spindle checkpoint protein BubR1, and inability to activate mitotic epitope MPM-2 in resistant cells when compared with the parental cells (...

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PMC10820104

The subsequent prenylation cascade of echinulin and neoechinulin series of alkaloids in Aspergillus ruber has been demonstrated to be mediated via two prenyltransferases, EchPT1 and EchPT2.

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PMC10297204

Electrophysiological signals were acquired using a NICOLET VIKING SELECT electromyography machine (Natus Neurology Inc., Middleton, WI, USA).

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PMC9429973

Methods: Single-center, retrospective study with 219 patients with SCD.

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PMC11578343

Zone lengths greater than 6 mm was not possible to test, given that the total “footprint” of the mz‐visco‐NPS channel would have surpassed the physical length of the glass substrate.

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PMC11001582

Source data We therefore investigated whether functional deficits were present, which would provide insight into the early brain changes in FTD and ALS.

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PMC7812570

The cotransfected cells were collected to analyze the cell-surface expression of GPI-anchored antibodies by FACS with an anti-His antibody as described above.

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PMC9429973

p=0.01; TCF3-PBX1 - 94.1% MRD neg.,

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PMC10114490

The strategy envisaged in this report allows, at a reduced time and cost expenses, the generation of an unlimited source of clonal, homogeneous, non-transformed hepatocyte-like cells, capable of performing typical hepatic functions and suitable for pharmaco-toxicological high-throughput testing.

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PMC11317131

By overcoming the lack of efficiency of current methods, numerous applications would be accelerated, including (i) integration into genomes of cell lines used in industrial biotechnology for the production of pharmaceuticals and other proteins (6); (ii) introduction of desirable traits, such as disease resistance or en...

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PMC11394730

It is noteworthy that QUE exhibits this effect at a low concentration (2 µM), which is less than 10% of its IC50 growth-inhibitory concentration, as determined by averaging eight different cancer cell lines (the mouse melanoma cancer cell line, human non-small cell lung cancer, glioblastoma, colon cancer, breast and pr...

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PMC10411253

The Arg312 of AMH is indicated in a black box. (

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PMC9429973

Previously, we described the incidence and outcomes of CMML at the population level (2004-2015) using the Surveillance, Epidemiology, and End Results Program (SEER) and National Cancer Database (NCDB) (Ruan et al., ASH 2020).

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PMC9429973

The last one is still on treatment (after 2 months).

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PMC11578343

Additionally, we identify viscoelastic differences among single cells from three different breast epithelial cell lines, MCF‐10A, MCF‐7, and MDA‐MB‐231.

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PMC5963610

Clinical response to Nimotuzumab and NGcGM3/VSSP vaccine by the sequential computed tomography during 122 months (A-E).

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PMC7917457

B16-OVA, a mouse melanoma cell line expressing chicken OVA, was kindly provided by Professor Richard Vile (Mayo Clinic, Rochester, MN, USA).

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PMC11509309

Pseudoceratinine A (3) showed no activity against PrP up to 20 µM. Pseudoceratinine B (6) was also inactive up to 10 µM and was cytotoxic at concentrations above 10 µM. Aerophobin-2 (4), which was used as a negative control as it was inactive against both [PSI+] and [URE3] yeast prions (Figure 3), was not active up to ...

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PMC2614415

It is also important to note that as the concentrations of VE-465 increased, both cell lines became increasingly aneuploid (data not shown).

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PMC9919300

Curcumin and andrographolide were dissolved in 100% DMSO as stock solutions and further diluted with bidistilled water (dH2O) to a desired concentration.

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PMC11756514

Samples prepared in spectrophotometer cuvettes included 400 µL of the bacterial suspension and 100 µL SP-D (to a final concentration of 1 µg/mL) or a control with no SP-D. OD650 was measured at the start of incubation and again after 16 h of incubation at 4°C.

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PMC9429973

In most cases, neither histological/immunohistochemical examination, nor PCR methods for determining clonality give a definite conclusion.

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PMC11763126

A Colony formation assay showing RCC cell proliferation after different treatments.

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PMC11461833

Notably, the most significant activation of HERVH-int was obversed in the STXBP5 OE group.

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PMC11463018

H NMR (500 MHz, Chloroform-d) δ: 8.01 − 7.97 (m, 2H), 7.91 − 7.86 (m, 2H), 7.47 − 7.40 (m, 3H), 7.37 − 7.34 (m, 1H), 7.17 (t, J = 8.6 Hz, 2H), 6.88 − 6.84 (m, 1H), 5.16 (t, J = 6.4 Hz, 1H), 4.66 (d, J = 6.1 Hz, 2H), 3.90 (s, 3H).

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PMC7802142

n ≥ 3; *P < 0.05, **P < 0.01, n.s.,

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PMC11045125

Colonies bearing the appropriate insert were identified by EcoRI digest of Qiaprep Miniprep Kit (Qiagen) DNA and submitted for sequencing by GeneWiz (Burlington, MA).

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PMC11723947

Lethally-irradiated B6 mice were grafted with a 1:1 mixture of B6 and B6D2F1 bone marrow and co-injected with WT or HP1α-deficient naive CD4 T cells alone or in the presence of ex vivo expanded WT Treg.

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PMC11502443

Mouse models deficient in RAMP1 and RAMP3 display enhanced body weight reduction in response to both GIP and GLP-1 (Leuthardt et al., 2023).

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PMC10656496

Cells were then plated on Greiner 96-well U-bottom, Cellstar® cell-repellent plates (Greiner Bio-One, Kremsmünster, Austria) using 3.5% Matrigel (Corning, Inc., Corning, MA) to form spheroids.

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PMC11064533

The strain was tested in multiple media to rule out media or synthetic/plastic surfaces, influencing clump formation as the strain strictly formed these structures on the epithelial cells and most prominently on the human urinary bladder cells.

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PMC9352806

Results showed that the effects of BMS on inhibiting fat accumulation was diminished in the daf-16 mutant, concomitant with the abrogation of lifespan extension (Fig. 4A and D, Table 1), hinting daf-16 was required in the BMS′ fat-lowering and lifespan prolongation functions.

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PMC11629461

Each data dot on the bar column represents one cell.

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PMC11803918

Melanoma is one of the most aggressive types of skin cancer, with high rates of metastasis and poor prognosis.

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PMC7602170

The mTOR pathway is activated in PDGFRA mutated and wt GISTs, which suggests that mTOR or upstream mTOR inhibitors may be potential therapeutic targets for primary resistant GISTs .

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PMC11738017

Similarly, for elranatamab at the recommended phase 2 fixed dosing of 76 mg, a higher baseline level of sBCMA (≥144 ng/mL) led to a lower probability of an objective response (Figure 44 of the New Drug Application and Biologic License Application document).

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PMC9676986

This steady growth is because the efficacy of FGFR inhibitors is low, and clinical responses to the agents are inconsistent (Katoh, 2019).

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