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PMC11306331
For subcellular activation (Fig. 2), the DMD region of interest was adjusted to encompass about half of the cell being imaged or encompass a single condensate in the cell nucleus.
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PMC9786247
The growth curves for all C. burnetii strains, except strains Nine Mile I, Henzerling and Scurry, in these bovine mammary gland epithelial cells were characterized by an initial lag-phase without replication or even with a decrease in genome equivalent (GE) numbers within the first 3 days post-inoculation (d p.i.).
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PMC10142392
Hydrophobic substrates such as drugs cannot be applied to hydrogels due to the thermodynamic incompatibility between the hydrophilic chain, water, and the hydrophobic drug.
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PMC11718817
Concordantly, we observed ample interaction between macrophages and CTLs in our spheroid model.
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PMC11695623
We detected the altered apoptotic ability of the cells by flow cytometry.
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PMC10926885
In conclusion, NDE1 has the potential to be a target for immunotherapy since it is associated with the percentage of cancer cells in tumours and other genomic abnormalities, such as spontaneous loss of nucleotides in repetitive DNA strands.
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PMC11461874
To strengthen our idea that TRAF7 ubiquitinates DBP, we assessed the TRAF7-dependent ubiquitination state of DBP.
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PMC10482220
Thus, it was possible that the recruitment of this domain to SGs was mediated through Ran or another small GTPase.
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PMC11787381
Results are expressed as mean ± SEM [(A): n = 6 except for bambuterol (n = 5), (B): n = 6 except for Aβ (n = 5)].
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PMC11756907
In addition, the C/O ratio was also compared to the results obtained using combustion elemental analysis.
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PMC9429973
BTN2A1 seems to be mandatory for Vγ9Vδ2 T cell activation but its precise role in modulating functions of Vγ9Vδ2 T cells remains unknown.
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PMC11583010
We also tested the effect of both ADCs on the EV-resistant SUM190R CDX model.
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PMC11763111
C The known related stemness-related gene are shown in the heatmap.
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PMC11657695
The effect of EWS::FLI1 re-expression was then studied 3 (Day 7 + 3), 4 (Day 7 + 4) and 10 (Day 7 + 10) days after cell treatment was stopped, respectively.
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PMC10818573
The quality of cellular products used in biological research can directly impact the ability to obtain accurate results.
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PMC10362265
We also compared the AF2 and homology model predicted complexes.
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PMC11637716
After extubating at the age of 3 weeks, further ventilatory support with continuous positive airway pressure (CPAP) followed by high‐flow therapy was provided.
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PMC6181431
Cell growth was assessed by Crystal Violet staining. (
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PMC11468365
This approach ensures that drug-drug combination pairs in the testing set do not appear in the training set.
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PMC11726848
Further study of the mechanisms of the formation of these cells, as well as their characteristics, will allow us to better understand the likely outcome of the tumor behavior after HDR irradiation. “
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PMC10329237
GAPDH was used as the loading control.
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PMC11343332
In addition, cells experiencing death displayed additional changes in shape, such as rounder cells that shrank and lacked a connection to neighboring cells.
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PMC5261804
Even so, the analyses presented here indicate that the sets of PPI essentialities that we have computed have strong biological relevance.
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PMC11544771
Next, we tested whether PRE strengthens the anticancer effect of CPX on NSCLC cells by bolstering CPX-induced DNA damage.
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PMC11670407
Transfected 143B cells were pretreated with 10 μM NAC for 1 h and then treated with cisplatin (10 μM) for 24 h. a Representative images of DCFH-DA staining for ROS and statistical analysis of fluorescence intensity (n = 3).
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PMC11720107
As a cytosolic enzyme, LDH’s presence in the culture medium effectively indicates cell membrane damage or cell death .
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PMC11746948
Scale bar, 1 mm and 100 μm.
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PMC10747139
A phase 2 study is ongoing (NCT03945162) to evaluate TLD1433 in non-muscle-invasive bladder cancer patients.
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PMC3931643
To determine whether 4EBP1 expression in VAL cells was also reduced at the transcriptional level, we measured 4EBP1 mRNA using a two-step RT-PCR and β-actin as an internal control.
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PMC11765678
The enhanced cytotoxicity of Adriamycin and Topotecan appears to result from increased drug uptake/retention due to inhibition of ABC transporter ATPase functions by NO or related species generated by Erastin.
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PMC11656048
It was then resuspended with PBS and analyzed by flow cytometry using AccuriC6 plus within 20 min.
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PMC9429973
Methods: From April 21, 2020 to November 30, 2021 46 patients with ALL (24 men, 22 women) with a median age of 44.5 (18-74) years were observed on the basis of the hematological service of the City Clinical Hospital No. 52 (Moscow).
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PMC9895440
At the same time, Tex enriched in the KIR+ TXK+ NK-like signature, which could suggest that they undergo an NK-like transition as recently described for exhausted CAR T cells.
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PMC9429973
2 of 6 patients who were aware of the WHO pain ladder had an admission to CUH in 2021, while 11 of 40 patients who were not aware had an admission to CUH in 2021.
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PMC7802142
HF transplantation is costly and there is a shortage of donor hair follicles .
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PMC11730305
Physical and chemical investigations of the synthesized nanoparticle showed that the synthesized particles had nano-scale dimensions and somewhat spherical shapes.
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PMC11401350
Additionally, the CD4 + T cell subset was depleted for Tfh PD-1 neoplastic cells in the CAR treated group (70%) as compared to the control group (Fig. 5F).
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PMC11752767
The major benefit of NK cells lies in their intrinsic anti-tumor capability, by inducing cell lysis through the release of perforin and granzyme and the degranulation .
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PMC11705862
All these events create a vicious circle inducing further inflammation, recruiting immune cells, and increasing the production of reactive oxygen species (ROS), which can damage cellular components, leading to further neuronal injury.
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PMC7090062
Fig. 2MiR-30a enhances imatinib sensitivity of GIST cells.
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PMC11190062
CpG stimulation similarly reduced TNFRSF17 gene expression ( Figure 6A ), and importantly, cell surface expression of BCMA was also reduced upon TLR4 or TLR9 activation ( Figure 6B ).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CpG", "stimulation", "similarly", "reduced", "TNFRSF17", "gene", "expression", "(", "Figure", "6A", ")", ",", "and", "importantly", ",", "cell", "surface", "expression", "of", "BCMA", "was", "also", "reduced", "upon", "TLR4", "or", "TLR9", "activation", "(", "Figure", "6B", ")", "." ] } ]
PMC5963610
was administered at days 3, 5, 7, 27, 29 and 31 plus NGcGM3/VSSP vaccine (200μg (s.c)) at days 7, 21, 32 and 45 or 7A7 mAb plus 14F7 mAb (200μg (i.v.
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PMC11730311
Wire myography was applied to study antagonism of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu against hαCGRP-induced relaxation of rat mesenteric arteries.
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PMC11144382
All animal studies were approved by the Medical Research Council Harwell Institute Ethical Review Committee and were licensed under the Animal (Scientific Procedures) Act 1986, issued by the UK Government Home Office Department (PPL30/2433 and PPL30/3271).
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PMC11297139
Published A673 in situ Hi-C data upon EWS/FLI1 depletion were downloaded from GEO database under accession number GSE185125.
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PMC11564322
Interestingly, in the MEG-A2 cell lines, the VGVAPG and VVGPGA peptides did not induce statistically significant changes in the NFKB2 mRNA expression, compared to the control (Fig. 3C).
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PMC11377827
This reporter has the advantage that it provides a dynamic readout to both endogenous HIF stability and transcriptional activation via binding to a triplicate HRE (Fig. 1A).
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PMC11543935
A: Experimental setup for an EP procedure including the electrode mounting interface positioned on a rail and the Bio-Phantom; B: Cross-section of the electrode mounting interface including the positioning support, temperature sensor and plate electrodes, and the Bio-Phantom consisting of the tumor hydrogel, healthy tissue phantom C: 3D-printed biopsy punch for isolating the ablation area of a hydrogel.
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PMC11711663
Future studies should aim to integrate genetic data, such as TP53 mutations and P16 overexpression, with radiomics data to provide a noninvasive, multi-modal approach to predicting outcomes in HNSCC.
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PMC9429973
In 2003, proteosome inhibitors such as bortezomib were introduced and, in 2015, anti-CD38 monoclonal antibodies such as daratumumab.
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PMC10656496
We thus present a proposed synthesis of the genomic and phenotypic worldview of shared osteosarcoma changes.
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PMC6617630
Likewise, BRD4 binding to the BCL6 promoter region in THL cell line was also decreased.
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PMC9429973
Average per-patient monthly (PPM) HCRU and costs were reported for the induction, post-remission, and post-relapse phases.
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PMC11650848
The Wechsler Preschool and Primary Scale of Intelligence, third edition (WPPSI-III) was used for the 7-year-olds and provides a score for Full Scale IQ as well as for specified cognitive domains (i.e. Performance IQ, Verbal IQ, and Processing speed) .
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PMC5963610
Images were analyzed/captured using the Olympus BX51 LTD microscope.
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PMC11088135
This may be a novel mechanism for glioma development, suggesting lncRNA NUTM2A-AS1 as a new potential therapeutic target for glioma.
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PMC11306331
Here we show that light-gated recruitment of a solubilizing domain, maltose-binding protein (MBP), results in rapid and controlled dissolution of condensates formed from proteins of interest.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "show", "that", "light-gated", "recruitment", "of", "a", "solubilizing", "domain", ",", "maltose-binding", "protein", "(", "MBP", ")", ",", "results", "in", "rapid", "and", "controlled", "dissolution", "of", "condensates", "formed", "from", "proteins", "of", "interest", "." ] } ]
PMC11627060
This size range facilitates the exploitation of receptor-mediated endocytosis pathways, which are more efficient for NPs of this dimension.
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PMC11684821
The results of a previous study (29) contrasted with our own by finding that the MC.7.G5 and MC.27.759S TCRs did not respond to MR1*01 homozygous and MR1*01/*02 cancer cell lines, prompting us to consider what had caused this disparity.
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PMC11297139
Recent studies revealed that PrLDs lack stable molecular structure, and aromatic residues within these domains function as “stickers” to mediate direct molecular interaction, whereas polar residues localized in between each aromatic residue function as “spacers” to distribute stickers evenly throughout the PrLD and modulate LLPS.
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PMC11615218
It is to be expected that our growing understanding of T-cell characteristics will allow the optimization of CAR-T cell manufacturing, the prediction of treatment responses, and the personalization of therapy.
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PMC11574029
Transwell chambers (Corning, 8 μm) with or without Matrigel were used to assess the invasion or migration abilities of BLCA cells.
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PMC11594588
The renewed interest in exocyclic DNA lesions in the 1990s was due to the development of ultrasensitive detection methods , notably for etheno and propano DNA adducts, which made it possible to study the formation of exocyclic adducts in experimental animals and humans.
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PMC11676674
The CBPI represents the average number of cell cycles per cell upon exposure to cytochalasin B, which should be between 1.5 and 2 cycles.
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PMC9429973
Median age was 54 (range 26-71); all patients received 2 or more prior lines of therapy and 44% (4/9) received ≥4 prior line of treatment before the study.
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PMC11228511
Orthogonal views of a nucleus from a wild-type SMC (WT SMC) stained with antibodies against lamin C (green) and lamin B1 (magenta).
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PMC11783017
As shown in Fig. 7G–I, the proportions of TCM and TEM cells in Cis/Mn/NH@PGP group were significantly higher than those in the other groups.
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PMC9429973
In a prior study, response was superior (CR/CRi >80%) with NPM1, IDH1/2, DNMT3A mutations, inferior with TP53, RUNX1, FLT3/ITD, RAS and prolonged survival with NPM1 and IDH2 mutations (2 yr OS 71.8%/79.5%) (DiNardo, Blood, 2020).
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PMC11190238
Mesenchymal cells lack functional epithelial junctions and exhibit back-front polarity in their actin stress fibers.
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PMC7724160
Table 4 contains both reverse phase and HILIC LC-MS metabolomics for all samples.
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PMC5874706
It is important to note that all THN7-loaded nanoparticles were more cytotoxic against A-427 cells than THN7 alone.
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PMC11411131
To enhance Krab-mediated gene suppression, we attempted to use a Krab-tandem construct and Sec at other positions in Krab.
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PMC10669966
In addition, PDE3A served as a drug target for PDE3A modulators in LPS cell lines, warranting further studies toward its usage in clinical therapy.
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PMC11594588
Diabetes and carbohydrate metabolism disorders are another factor inducing oxidative stress.
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PMC10919056
The ROC curve demonstrated that the RS prognostic model exhibited a potent ability to predict patient survival rates (the AUC for predicting 1-year, 2-year, and 3-year survival rates were 0.740, 0.781, and 0.771, respectively).
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PMC11699465
All of these cancer immune-associated genes are potentially regulated by nuclear TMEM199.
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PMC11155445
Thiourea reversibly form formamidine disulfide under oxidation conditions, which further through various steps under oxidative conditions form SO4.
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PMC11731614
The medium was a combination of 50% DRG culture medium as previously described (Menichella, 2016) and 50% keratinocyte culture medium when both cell types were present in the chambers.
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PMC9429973
Results: Of 74 patients who underwent leukapheresis, 61 received liso-cel and 1 received nonconforming product (ie, product wherein one of the CD8 or CD4 cell components did not meet one of the requirements to be considered liso-cel).
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PMC7917457
However, in the combination therapy group, 8/9 (88.9%) mice were still alive at that time point.
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PMC11621493
In the absence of CaCl2, hPLA2G4D exhibited highest activity against the zwitterionic phospholipid PE, followed by PC, while anionic phospholipids and lyso-phospholipids were barely degraded (Fig. 1D and E).
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PMC7185206
To characterize sPD-L1-mediated immune cell death, we treated CD8 + T cells from healthy human donors over 48 h with recombinant Fc fusion PD-L1 protein (Figure 4(a), Supplemental Table 5).
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PMC11766174
After incubation with compounds, cells were collected for measurement of cellular CA by CA-ICC and flow cytometry and viral RNA by qPCR with the methods described above.
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PMC7759933
It is well known that KI67 protein is present during all active phases of the cell cycle (G1, S, G2, and M), and it is absent from the resting cells (G0) .
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PMC11271278
Source data are provided as a Source Data file.
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PMC9532503
An important Fc region mediated immune effector function that play prominent role in removal of tumor cells is antibody-dependent cell-mediated cytotoxicity.
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PMC9398137
C, Antitumor efficacy of S63845, venetoclax (VEN) or combination of both agents (S63845+VEN) compared with untreated control animals (CTRL) in six PDX models of aggressive B-NHL.
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PMC11422497
Categorically, circRNAs can be classified into four types based on their source: exonic circRNAs (ecircRNA), intronic circRNA (ciRNA), exonic- intronic circRNA (EIciRNA), and intergenic circRNAs.
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PMC10507284
Our sequencing and PCR results show that the expression of TROAP is elevated in STS compared with normal tissues and cell lines.
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PMC11359735
The three fatty acids (shown in blue) within the phosphatidylinositol group, two attached to glycerol and one to the myo-inositol ring, anchor the protein to the cell membrane.
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PMC11730000
mTOR expression in the CHO-K1 cell line was determined by western blotting.
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PMC11012012
The expression of SLAMF5/CD84 is relatively low and stable throughout maturation while SLAMF6/CD352 expression greatly increases after mature B cells leave the bone marrow, and then it remains stably high.
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PMC9429973
Cytotoxic Natural Killer (NK) lymphocytes have been extensively studied for their anti-leukemic activity.
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PMC9429973
Results: The importance of selecting an appropriate survival model was demonstrated by the large variations seen in the 5-year survival estimates of the different extrapolation models, which ranged between 0%–45%, 10%–55%, and 0%–47% over all data cutoffs of JULIET, ZUMA1, and TRANSCEND NHL 001, respectively.
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PMC11337594
Similarly, in the UK, the incidence of melanoma increased from 5.8 to 19.8 between 1982 and 2011, and in Sweden and Australia, it increased from 13.0 to 28.3 and from 26.4 to 51.6, respectively .
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PMC11087766
PhiPA3 gp210 is normally excluded from the PhiKZ phage nucleus, but gp210-GFPmut1 is imported, where it becomes toxic by cleaving the PhiKZ genome at a single recognition site and preventing replication (15, 16).
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PMC10213179
FBS medium (10%) was placed on the lower side of the chamber and served as the chemoattractant for inducing migration.
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PMC4355729
Antibodies that recognize pAKT (Ser473) (Cell Signaling Technology, #9271), AKT (Cell Signaling Technology, #9272), pERK (Thr202/Tyr204) (Cell Signaling Technology, #4370), ERK (Cell Signaling Technology, #4695), p85α (Santa Cruz, sc-376112), p110α (Cell Signaling Technology, #4249), β-actin (Sigma, A1978), NCAD (Abcam, AB98952), ECAD (Cell Signaling Technology, #3195), VIM (RV202) (Abcam, AB8978), ZEB1 (D80D3) (Cell Signaling Technology, #3396), pGSK3β (Ser9) (Cell Signaling Technology, #9323), GSK3β (Y174) (Abcam, AB32391), and non-phospho CTNNB1 (Ser33/37/Thr41) (Cell Signaling Technology, #4270) were used in the study.
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PMC10818573
EBV is also recognized as a tumor-associated virus and was declared a class I carcinogen by the International Agency for Research on Cancer and the World Health Organization in the late 1990s .
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PMC11317131
The accessory plasmid (AP) contains the attP site and C-terminal portion of gIII.
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