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PMC11594588
Now, for the first time, intracellular O2 can be conveniently monitored within the cell monolayer on a plate reader in a non-invasive, high-throughput manner and in real time.
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PMC10123657
Valid identifications of mouse peptides in human CCRF-CEM cells were based on: (i) absence in the human proteome and presence in the mouse proteome according to the Protein BLAST tool (https://blast.ncbi.nlm.nih.gov/Blast.cgi accessed on 20 July 2022) where mismatches should not be I instead of L, and (ii) the actual detection of the difference in the mass-to-charge signals between consecutive b- or y-type ions in the CID fragmentation spectrum for at least one of the amino acid residues representing mismatches when the sequences of the corresponding mouse and human peptides with the highest sequence identity were aligned (Supplementary Table S1).
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PMC11604830
a 1:14 factor (calculated considering an injected volume of 125 μL and total blood volume of 1.8 mL), the PFCE‐NE turned out to be the most promising system for attaining an in vivo proof of concept of this approach.
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PMC9429973
Two patients died of ICH, and one patient with subdural hematoma died from pseudomonas sepsis and multiorgan failure.
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PMC10253973
Ruthenium complexes with various bioactive ligands such as hormone receptors, growth factors and enzymes are commonly used as potential anticancer agents, especially against hormonal breast cancer and triple negative breast cancer (TNBC).
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PMC11775197
It is widely acknowledged that PPARγ activation facilitates the inhibition of tumor angiogenesis .
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PMC9105697
Formalin-fixed paraffin-embedded (FFPE) tumor tissue, plasma and whole blood samples were available for analysis.
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PMC11477621
The crude product was purified by silica gel chromatography to give the colorless oil 4j (724 mg, 89%).
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PMC11470999
A pivotal finding of this study was the identification of CIP2A as a direct target of PF, laying the foundation for a deeper understanding of the antitumor mechanisms of PF.
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PMC11448304
Additionally, 1038 of 2-hydroxyisobutyrylated sites were downregulated, while 791 of sites were upregulated (Table S3).
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PMC11549062
RNAi: RNA interference.
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PMC11476004
The material for the study was peripheral blood drawn from the basilic vein of Molosser-type dogs of two breeds (St. Bernard dogs (B1) and Bernese mountain dogs (B2)), 20 cases and 10 controls per breed, with an equal number of males (M) and females (F) among cases and controls (healthy (H), cancer (C)).
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PMC11052306
Dendrimers 11-G0-[CuCl2]4 and 12-G0-[Cu(ONO2)2]4 strongly affected U937 tumor myeloid cells viability, by inducing late apoptotic/necrotic cells in 75% and 95%, respectively , while they poorly affected the viability of PBMC normal cells.
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PMC9429973
The Survival of patients in CR was 96.3±3.6%, which means almost all patients have recovered from COVID-19 and were discharged to continue their treatment in other medical institutions.
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PMC8073654
The rhizomes of Z. cassumunar were used as an anti-asthmatic drug in Thai traditional medicine.
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PMC11025866
No studies of the effects of valpromide on SLC7A11 or any of the drugs on CHAC1 were found in the literature.
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PMC10154881
We transplanted E.G‐7/N4 into B6 mice, followed by two doses of rMV‐SLAMblind (n = 6/group).
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PMC11721587
Of note, the SUMO epitope was not detected in the SDS-resistant Ulk3 oligomers (Fig. 6H) but was detected in the Ulk3 monomers derived from the oligomers after prolonged incubation in 2× SDS loading buffer (fig. S6K), suggesting that the mature Ulk3 was SUMO-conjugated, but the SUMO epitope was masked.
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PMC9096373
Statistical analyses were conducted using the software SPSS 17.0 (SPSS, Inc., Chicago, IL, USA).
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PMC11730311
Experiments were performed in singlicates.
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PMC11790599
Hematoxylin and eosin staining of the 2–3 mm sections of tumors derived from xenografted ZR-75-1 cells treated with TSL (0, 2, 6.32 μΜ) for 72 h (20×).
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PMC11597291
In agreement with a more efficient shielding of GO surface by the branched (multi-armed) PEG, we observed a lower PCT loading capacity in nCGO-PEG(4-arm 10 kDa) compared to nCGO-PEG(10 kDa) (Table 2).
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PMC10654497
Ferroptosis, controlled cell death that involves a high degree of iron-dependent lipid peroxidation, has been linked to tumor therapy sensitivity, patient prognosis, and cancer development.
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PMC9841531
Yellow solid; yield: 76%; melting point: 186–188 °C: FTIR (cm): 3121.03 (NH), 2215.61 (CN), 1659.20 (C=O), 1591.52 (C=O), 1515.21 (C=C); H NMR (400 MHz, DMSO-d6) δ 11.20 (s, 1H), 8.64 (s, 1H), 8.54 (s, 1H), 8.46 (d, J = 2.4 Hz, 1H), 8.00–7.90 (m, 3H), 7.59–7.53 (m, 1H), 7.30 (m, 2H), 5.38 (s, 2H), 3.80 (s, 3H); MS (m/z) calculated for C21H15Cl2N3O3: 427.049, found 425.950 [M – H] and 463.950 [M + K]; purity (HPLC): 96%.
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PMC9000591
Recently, plant-based products have been widely deployed in many countries around the world for therapeutic purposes.
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PMC11640476
To meet this challenge, an effective strategy should involve optimizing experimental parameters, specifically improving and standardizing laboratory protocols.
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PMC11706491
The MAP kinase Sty1, on top of being essential for the cells to survive stress situations, has been believed for more than 30 years to be involved in the regulation of cells cycle under unstressed conditions .
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PMC11409031
In Fig. 3E, the evolution and differentiation of cell subpopulations are depicted.
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PMC11462673
Robust inhibition.
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PMC11144382
Vcam1 expression was confirmed by qRT-PCR analysis to be significantly decreased in the Nfix MEFs (0.3-fold, P <0 .05), compared with the mean expression in the Nfix, Nfix, Nfix, Nfix, Nfix and Nfix MEFs (Figure 2C).
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PMC11441402
This allowed for net cell growth inhibition and cell death to be determined.
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PMC11678368
The trans-[PdCl2(4ClL)2] solution remained turbid after dissolution, while solutions of the other compounds were clear.
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PMC9429973
Summary/Conclusion: Pegfilgrastim was well tolerated in all patients: main side effects in our patients were mild fever and bone pain (21.2%).
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PMC8759873
The apoptosis rate increased significantly.
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PMC10882807
The percentage of cells in each phase is shown in Fig. 4D-F. All these results proved that hsa_circ_0005397 promotes growth in HCC cell lines.
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PMC9918897
The intervention started immediately after the cell implantation.
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PMC11549062
Further, PTP1B modulated PDGFR‐β signaling via Rab5‐mediated endocytosis.
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PMC9429973
Prophylaxis was typically continued for a year after ASCT.
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PMC11488203
The concentrated supernatant of about 250 µl was then applied to a PURE-EVs column (HansaBioMed Life Sciences, Tallinn, Estonia) for size exclusion chromatography (SEC).
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PMC11597291
The effect of PCT-loaded, 6-armed PEG-functionalized graphene oxide particles on the viability of A549 cells was investigated by Xu et al. , who reported a significantly increased cell death close to 70% at 1.29 mg/L particle concentration.
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PMC11496728
The development of this protein therapy requires the use of mammalian cell lines, not bacteria or yeast.
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PMC9429973
We next investigated the downstream T-cell signaling and found the higher baseline pNF-κB and pRelB of CD19.28.40z CAR-T cells compared to the others.
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PMC11761919
The values represent mean ± SD, n=3. **
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PMC11634794
Our study highlights the potential of LAMP1 as a novel biomarker for diagnosing ccRCC patients and predicting their prognosis, while also providing valuable insights into the underlying molecular mechanisms that could guide targeted therapeutic strategies for renal cancer.
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PMC11541409
Changes in the metabolism of GIST cells were assessed based on the presence or absence of TKIs treatment and their sensitivity to TKI therapy.
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PMC5716223
To facilitate cell analyses, the bottom of each well was divided into ten square fields and in each field the number of myotubes and nuclei/myotube were counted manually at a final magnification of ×40 (Olympus BX41 microscope, Olympus) using an ocular grid.
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PMC8998437
We also demonstrated previously that CCR2 (isoform CCR2B) was expressed and that the receptor was functional in LCLs and in three endemic BL cell lines (Mutu cl.99, Mutu III, and Jijoye P79), in which the EBV-encoded latent protein EBNA2 is abundantly expressed (Figure 2D).
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PMC11754291
Additionally, the cells were exposed to light in PBS to prevent the absorption of blue light by phenol red and other biomolecules in the culture medium, which could otherwise lead to the generation of reactive oxygen species (ROS) and potentially harm the cells.
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PMC11785489
After normalizing gene expression, we used the variance-stabilizing transformation (VST) to select the 200 most variable genes in each sample, excluding TCR genes.
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PMC7338939
The PCR products were submitted to conventional Sanger sequencing.
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PMC11015054
However, we also noted deficiencies in this study.
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PMC10926885
M, N) The effect of NDE1 on the proliferation ability of T24 and 5637 cells was explored by colony formation assay. *
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PMC10729469
Data presented as mean ± SEM E. Representative histograms of Aβ-mediated Treg suppressive function of engineered Tregs co-incubated with pre-stimulated CFSE+ Tresp cells in the presence of Aβ-tetramer or control-tetramer.
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PMC10758402
A table presents clinical characteristics of patient-derived tumor specimens used in this study. (
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PMC9429973
Secondary endpoints include investigator-assessed PFS, overall survival (OS), overall response rate (ORR), duration of response (DoR), safety and tolerability, and patient reported outcomes.
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PMC10582049
The next question to be analyzed was whether ADH1B expression in LUADs correlates with anti-cancer immune response.
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PMC11607764
The reporting of this study conforms to ARRIVE 2.0 guidelines.
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PMC10411253
Adult cases are reported less frequently, and few AMH variants have been reported in Chinese individuals.
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PMC10317042
The blocked membranes were incubated with primary antibodies (shown in Supplementary Table S1) in Can Get Signal Solution 1 (Toyobo) at 4°C overnight, after which they were incubated with secondary antibodies in Can Get Signal Solution 2 (Toyobo) at room temperature for 1 hour.
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PMC11088135
A qRT-PCR was performed to analyze the expression of miR-376a-3p in U251 cells.
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PMC9599726
For each TMA, KIT, YAP, and TFRC, staining intensities were scored individually by two researchers (Jean-Marie Vanderwinden and Marine Delvaux) blinded for clinicopathological information, and the results were assembled by consensus.
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PMC10713411
Programmed cell death (PCD), a common modality of cell death, affects tumor development and acts as a target for tumor therapeutics.
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PMC8526701
During the last couple of years, several small molecular inhibitors were detected that primarily target the expression of BET proteins and were developed due to their anticancer effects both in vivo and in vitro .
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PMC9581083
One is to directly inhibit the entry and replication of the virus, mainly to clear heat and detoxify such as honeysuckle, Radix isatidis and Scutellaria for inhibition.
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PMC11794568
Studies have reported that TFAM abnormalities can promote drug resistance and aggressiveness of BRAF inhibitors in melanoma.
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PMC10196713
The following primers were used: Fdx1 forward, 5′-AACAGACAGATCACGGTTGGG-3′ and reverse, 5′-GGTCTTGCCCACATCAATGG-3′; Tmp1 forward, 5′-ACTACCTGCAGTTTTGTGGCT-3′ and reverse, 5′-CTGGTCCGTCCACAAGCAA-3′; and Usp17l11 forward, 5′-CAGCTCAGAGTGTCCAGCAA-3′ and reverse, 5′-AGTTAACGTCTTGGAGGCCG-3′. Total RNA was extracted from A2780, A2780cis OVK18 and OVK18cis cells by using Sepasol-RNA I SuperG (Nacalai Tesque, Inc.).
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PMC9429973
Six patients had ≥1 bleeding event, none were treatment-related; no related serious adverse events or deaths.
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PMC11594641
All the tested cell lines were seeded into 24-well culture plates at a density of 1 × 10 cells/well and grown in 1 mL of complete medium for 24 h. The confluent monolayer of the cells was scratched using a sterile P-20 pipette tip and the cells were washed twice with PBS.
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PMC11578343
When comparing the viscous G″ between the Lat‐A‐treated and control cells (Figure 2D; Figure S3B, Supporting Information), we did not observe significant differences.
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PMC10705095
The results revealed a significant decrease in tumor volume following HBQ1 knockdown using shHBQ1 (Figure 4a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "revealed", "a", "significant", "decrease", "in", "tumor", "volume", "following", "HBQ1", "knockdown", "using", "shHBQ1", "(", "Figure", "4a", ")", "." ] } ]
PMC3164356
The CHO genome will aid cell line engineering by facilitating the application of experimental and computational sequence-based tools for genetic manipulation and genome analysis.
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PMC10850553
Up-regulation of C5ar1 under starved condition in NIH3T3 cells.
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PMC10040136
To explore the underlying mechanism of MSC-mediated GIST drug resistance, Plerixafor, Lenalidomide, and Galunisertib were introduced into the co-culture system as CXCR4, TNF-α, and TGF-β inhibitors, respectively, to evaluate their impact on GIST cell survival.
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PMC5963610
Administration of treatment with PBS, 7A7 mAb, NGcGM3/VSSP vaccine, combined therapy or NK 1.1 depletion is indicated in the schematic representation (A).
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PMC11755519
Proteomic characterization of used extracellular vesicles.
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PMC9964635
Yield 71%.
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PMC11568601
Increasing evidence strongly suggests that targeting ER stress is a promising strategy for cancer treatment .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increasing", "evidence", "strongly", "suggests", "that", "targeting", "ER", "stress", "is", "a", "promising", "strategy", "for", "cancer", "treatment", "." ] } ]
PMC6617630
VAL MYC 3R1G2F, BCL-2 3R1G1F, and BCL-6 1R1G1F (g-i).
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PMC11621565
Cells were seeded at a density of 3 × 10 cells/well on E-16 plates and observed during differentiation.
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PMC6181431
In 786-O cells, 4 different shRNA clones (sh889, sh890, sh994, sh326) were used to generate stable lines with reduced PBRM1 expression (Fig 1A).
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PMC11088135
p < 0.01 vs. mimic control group YAP1 is a direct target of miR-376a-3p.
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PMC11119602
Hence, the intracellular location and activity state of transglutaminase differentially impacts on cell death and the role of TG2 in cellular functions .
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PMC11705630
A recent study, however, showed a slower growth of tumor in GLDC knock-out HepG2 grafted mice 37.
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PMC9429973
Results: Lower quantitative limit of detection of the BCL2 ddPCR assays was tested and could ubiquitously be established as 0.01%.
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PMC11770199
Twenty hours after transfection, cells were labeled with probe of caspase-3/7 and nuclei were stained with Hoechst 33342 and subsequently imaged with a fluorescence microscope. (
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PMC7582629
According to a report, 30% of breast cancers have an amplification of the human epidermal growth factor receptor 2 (HER2)/neu gene or overexpression of HER2 protein .
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PMC11612315
HEK293 and HEK293T cells were also cultured in the same DMEM but without geneticin.
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PMC11569208
48 hours later, cells were infected with VSV∆51-GFP (MOI 0.01).
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PMC6222726
Picropolygamain (8) was isolated for the first time in 1985 from Commiphora incisa resin and later from Bursera simaruba .
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PMC9429973
Analysis of gene signatures from CMML-derived monocytes has shown them to be highly proinflammatory.
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PMC11629143
After washing, SuperSignal ELISA Pico (Thermo Fisher Scientific, 1859677) detection agent was added and mAb levels were quantified on a CLARIOstar Plate Reader (BMG Labtech).
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PMC9429973
Patients with DS 3 and 4 completed 6 ABVD cycles and involved-field radiotherapy in hypermetabolic areas in interim PET3.
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PMC7757104
The present study aimed to evaluate the expression patterns of each tested OPN-SI in cisplatin (CDDP)-resistant ovarian carcinoma cell lines, focusing on the role of the OPN-c isoform (OPNc) in drug resistance.
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PMC11705862
In short, two primary antibodies bind to their target epitopes, located on a single protein or two nearby proteins.
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PMC11768927
Similarly, upregulation of miR-34a, achieved through treatment with histone deacetylase inhibitors (HDIs), led to decreased SIRT1 expression, which in turn enhanced both viral replication and cellular apoptosis.
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PMC6889484
Alternatively, a 982-nt puro-WPRE (woodchuck hepatitis virus post-transcriptional regulatory element) region was amplified using primers puroFor (5′-CGCGCAGCAACAGATGGAAG-3′) and nefRev (5′-CTTGTGCTTCTAGCCAGGCA-3′).
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PMC11365427
Phenylalanine deprivation enhanced the recruitment of DR5 and caspase-8.
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PMC11656380
Figure 3A–C illustrates a dose-dependent decrease in cell viability of most leukemia and lymphoma cells following Tat-Ram13 treatment.
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PMC6803987
In this experiment, the HepG2.2.15 cell model was used to study the anti-HBV activity of esculetin from Microsorium fortunei.
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PMC8711270
γRV production is then achieved by transfection of the packaging cell line with a single vector construct carrying the transgene-of-interest, the Ψ packaging signal, and a modified long terminal repeat (LTR) species to further minimize risk of RCV formation (Rodrigues et al., 2011).
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