Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11252553
treated with cysteine (100 µg.
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PMC9512971
Other than the patient classified as grade 5 on day 9, none of the other patients in either group experienced a worsening in the ordinal scale by at least two categories at any time during the study.
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PMC11402217
∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001.
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PMC9910796
Quantification of immunogold labeling.
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PMC9429973
There was no significant difference in PFS (HR: 1.01, CI: 0.71-1.44, p=0.94) or OS (HR: 0.84, CI: 0.49-1.43, p=0.52) between the Len-only and the Len-combo groups, respectively.
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PMC9429973
41.9% of the responders had undetectable MRD.
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PMC11686380
In the merged images, GAP43 is shown in green and RFP is shown in red.
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PMC9503541
Fractions F15-16C and F15-16D exhibited the highest anticancer activity in the MTS assay, with % cytotoxicity values of 99.6% and 99.4%, respectively.
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PMC9429973
A high proportion of pts (80%) felt that the pandemic had an impact on their medical care (Figure) (adults: 85%;[PM(1] pediatric: 76%).
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PMC8481254
In addition, immunofluorescence (IF) detection results showed that CA could increase the apoptosis of Bel-7402 and Bel-7404 cells (Supplementary Fig. 2C).
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PMC9429973
Image: Summary/Conclusion: DAC + VEN + QUIZ is active in R/R FLT3-ITD mutated AML pts, with CRc rates of 78% and the median OS of 7.6 months.
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PMC7759933
Recently, several published studies have described the higher expression of CYP enzymes in hepatic cells cultured in 3D conformation .
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PMC11225860
Cells were stained for one hour using a propidium iodide solution (100 mg/mL RNase, 150 mg/mL propidium iodide, and 5 mM EDTA-pH 8.0) and analyzed via flow cytometry for 100,000 events.
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PMC6627640
Approximately 80% of TGCT patients are cured of their disease with cisplatin-based combination chemotherapy even when the disease is highly metastatic .
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PMC11472639
Fig. 1 Participant characteristics.
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PMC9504875
In the present study, HAZV N protein was found to suppress type I IFN production.
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PMC11612508
The swelling increased over time, initially quickly and then more slowly, until it reached a constant maximum.
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PMC8481254
Here we found that CDK19 and O-GlcNAcylation were positively correlated in liver cancer tissues and cell lines.
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PMC9545474
Again, the non‐equivalences of the quaternary carbonyl carbons (170.04 and 169.68 ppm), and acyl methyl carbons (21.73 and 21.42 ppm) are observed in the C NMR spectrum of complex 5 (Figure S5).
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PMC11805741
A volume of 20 mL of PYT medium was inoculated with freshly activated colonies of the selected bacterial isolate and incubated overnight at 200 rpm, 30 C. One liter of the production medium (PYT) was sterilized and inoculated with 5% of the activated culture, then incubated under the same conditions for 48 h. At the end of the cultivation time, cell pellets were harvested via centrifugation at 2000 g for 15 min.
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PMC3915447
Our outcomes clearly indicate that a SPIO-FA-based drug delivery system can decrease the IC50 of FA and induced apoptosis in CCRF CEM cells.
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PMC11701801
Samples were cut into 3-mm squares (30 mg) and milled in liquid nitrogen before extraction of mRNA using the Animal Tissues protocol from RNeasy Mini Kit (QIAGEN; 74104) and a QIAshredder (QIAGEN; 79654); the final elution volume was 50 μL. Next, cDNA was synthesized using PrimeScript RT Master Mix (Perfect Real Time; Takara; RR036A).
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PMC11637276
Cells were incubated at 37°C and 5% CO2; images were acquired every 10 min for at least 7 h and more than 40 cells per well were quantified per biological replicate.
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PMC11656048
Shikonin molecular structure and 3D structure from the PubChem database (https://pubchem.ncbi.nlm.nih.gov) (Figure 1A).
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PMC9429973
The top 3 procedure codes were for stem cell transplant, ventilation and bone marrow extraction.
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PMC11472639
Peripheral blood mononuclear cells (PBMCs) were isolated from heparinised blood, using SepMate™ tubes (StemCell Technologies, Vancouver, Canada) following manufacturer recommendations.
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PMC11519788
Conclusions: A pivotal role of SPOP in maintaining UBC stemness and remodeling immunosuppressive TME was revealed.
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PMC11544122
Delta BRET was calculated by subtraction of the vehicle signal from each dose.
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PMC11721064
To develop a method for enriching keratinocyte progenitor cells (KPCs) and establish a limbal niche (LN)-mediated transdifferentiation protocol of KPCs into corneal epithelial cells.
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PMC11672881
In contrast, combining two or more phytochemicals can provide significant advantages over monotherapy by targeting multiple pathways simultaneously, reducing the likelihood of resistance .
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PMC7987994
It contains amino acids, proteins, vitamins, carbohydrates, lipids, hormones, growth factors, inorganic salts, trace elements, and other compounds.
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PMC3035438
The percentage of surface IgM-positive cells (IgM) was determined by measuring the FITC fluorescence intensity with the Cytomics FC500 flow cytometer (Beckman Coulter).
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PMC11697189
Significant difference in OS was observed according to risk score in the high TMB subgroup and the low TMB subgroup (low TMB and low risk score vs. low TMB and high-risk score; high TMB and low risk score vs. high TMB and high-risk score; Fig. 8F).
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PMC10976516
For this, the pitfall of systemic OV application must be overcome.
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PMC11464982
To avoid the confusion introduced by the description of an Aspergillus enzyme produced by Penicillium, the designation endonuclease is used throughout the opinion.
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PMC10589262
As shown in Fig. 1E, MT-KIT in GISTs was primarily in the post-ER form, which indicates that MT-KIT is folded enough to avoid ER accumulation and stress induction.
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PMC11721587
Although the pT158/S159 antibody could recognize both the monomeric and dimeric Fu on SDS–polyacrylamide gel electrophoresis (SDS-PAGE) (Fig. 2, A and B, and fig. S3, A and B), the pS482 antibody only recognized the monomeric but not the dimeric form (fig. S3B).
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PMC11607321
Notably, the conditionals emerged as the second most important omics, reflecting the critical role of tissue of origins, mutations, and growth rate in influencing drug responses (Supplementary Fig. 8a).
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PMC6181431
Three patients’ tumors showed mutations in TSC1, while one had a mutation in PTEN, and some of these patients had been included in our previous study showing that there is enrichment for mutations in mTOR pathway genes in RCC patients who respond to rapalog therapy .
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PMC9429973
The Kaplan-Meier method was used to assess DFS and OS, comparing ASCT vs No-ASCT and Maintenance vs No-Manteinance.
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PMC11757230
Our results showed that cADSCs inhibited the growth of CLC lymphoma cells in a dose-dependent manner.
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PMC11666785
In addition, frequency analysis is carried out to determine the presence of high frequencies that represents edge information and/or minute features in the image.
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PMC11200978
Cryoablation has emerged as a promising approach for various cancers, including non-small-cell lung cancer (NSCLC) .
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PMC7192625
Grey dots indicate distance preserving randomizations. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grey", "dots", "indicate", "distance", "preserving", "randomizations", ".", "(" ] } ]
PMC9429973
Summary/Conclusion: As reported previously, recommended dose of MB-CART2019.1 is 2.5x10 CAR T-cells/kg BW.
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PMC11695546
6Anti-Alzheimer of crude and ozonized coconut oil compared to rivastigmine as a standard drug (results are illustrated as means ± SD) Anti-Alzheimer of crude and ozonized coconut oil compared to rivastigmine as a standard drug (results are illustrated as means ± SD) The cytotoxic impacts of crude and ozonized coconut oil were tested using MTT assay towards A431 cells and it could be seen that upon using different concentrations from 1000 to 31.25 of the oil to ozone slightly elevate its cytotoxic impact where IC50= 484.96 ± 5.4 and 467.11 ± 4.15 µg/mL for crude and ozonized oil respectively as shown in Table 3 and Fig. 7.Table 3Determination of cytotoxic effect of different coconut oil and after exposing to O3 on A431 cells (Data are tabulated as means ± SD)TreatmentDose (µg/mL)Mean O.D ± SEViability %Toxicity %Ozonized10000.0886670.00233311.9788.035000.3266670.0044144.0855.922500.7356670.00145399.280.721250.7390.00057799.730.2762.50.7403330.00033399.910.0931.250.7406670.00120299.960.040.00.7410.0005771000IC50467.11 ± 4.15 µg/mLControl10000.0886670.00233311.9788.035000.3266670.0044144.0855.922500.7356670.00145399.280.721250.7390.00057799.730.2762.50.7403330.00033399.910.0931.250.7406670.00120299.960.040.00.7410.0005771000.0IC50484.96 ± 5.4 µg/mLFig.
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PMC11774747
In the trial NCT04288726, which investigated CD30.CAR-EBVST, the safety of allogeneic CAR-VSTs was further confirmed in 14 patients.
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PMC11721064
CXCL14, a chemokine secreted by epidermal keratinocytes that rhythmically activates the innate immune system, suppresses skin bacterial proliferation .
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PMC11750712
AUTO4 is manufactured from autologous T cells that are transduced with a bi-cistronic γ-retroviral vector encoding a TRBC1-specific CAR, coexpressed with the sort-suicide gene RQR8 (ref. ).
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PMC10940855
RPMI-8226 cells that constitutively express firefly luciferase were utilized for these studies (courtesy of Dr. Alan Lichtenstein, Hematology/Oncology, VA West LA Hospital, Los Angeles, CA).
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PMC11513011
Safer and more effective treatments are needed.
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PMC10204952
Furthermore, we identified 36 upregulated and 21 downregulated secretome genes in differentiated SGBS adipocytes treated with 100 nM S1P.
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PMC5839394
Stronger interactions are represented by thicker lines. (
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PMC11406030
Common epitopes were identified by subtraction of the isotype control epitope sequences.
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PMC11411004
I-4 at a concentration of 2 μM was added to suspension-cultured CHO-ADM cells.
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PMC10890055
The hFOB 1.19 cell line has already been used in cancer research and osteomyelitis research as well as in studies with permanent and degradable biomaterials.
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PMC11095939
The Alb-cre (JAX stock #025200) mouse strain was obtained from Jackson Laboratory (Bar Harbor, ME).
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PMC2614415
We confirmed Aurora-A expression at the protein level by staining tissue microarrays from the same patients.
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PMC11566417
Overall, PDT of primary MDECs remained relatively constant, with a slight upward trend, indicative of a sustained, albeit slightly slowing, growth rate (best-fit slope = 0.04), whereas the PDT of immortalized MDECs trended downwards, indicative of a sustained, slightly increasing growth rate (best-fit slope = − 0.13) (Fig. 3a).Fig.
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PMC10729469
Phenotype characterization of engineered TCRAβ-Tregs shown in Supplementary Fig. 3.
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PMC9727330
Colorectal cancer (CRC) is the type of cancer that starts in the colon or rectum known as bowel cancer or colon cancer (Kim and Chang 2014).
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PMC11754094
N and C indicate the amino-terminal and carboxy-terminal ends, respectively.
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PMC11317131
Following 15 days of culture to prevent detection of non-integrated, transient vWF expression, we detected a 3-fold increase in protein expression for the evolved integrase (Figure 6F–H).
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PMC11644761
Considering that the present results were obtained using a neuroblastoma cell line, future studies should focus not only on primary neuronal cells but also on in vivo systems.
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PMC11720107
The absorbance value was proportional to the levels of the studied proteins.
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PMC11721277
The biodistribution pattern showed common trends for all doses studied of 1.2 mg/kg, 6 mg/kg, and 12 mg/kg 2 h after injection, except for the uptake levels in several healthy organs.
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PMC11591794
These proteins are located in the mitochondria and control the release of P53, an important tumor suppressor that can modulate key checkpoints in both extrinsic and intrinsic pathways .
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PMC10362265
However, the other pair became separated, resulting in disruption of the other interface (Fig. 6, orange).
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PMC10197932
Overall, we demonstrated that CD3/CD8 lymphocytes proliferation/activation and cytotoxic functions are fully preserved after ultrasound treatments, whereas leukemia cell lines undergo apoptosis and stop proliferating suggesting a potential method of treating blood cancer.
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PMC3122064
Additionally, p53 suppression in wild-type p53 TC cells prevented the induction of Fas membrane expression by Nutlin-3 treatment (Figure 4c).
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PMC11700247
When the STING pathway activation is inhibited, the antitumor effects of both RT and CART-19 cell therapy are significantly impaired.
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PMC10547921
Only then will the subsequent optimization and transformation of the parent nuclear compound be efficiently carried out.
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PMC11727145
As described previously , the exudates from superficial burns of the second or deeper degree were collected from burn patients in our burn center (Lausanne University Hospital, Lausanne, Switzerland).
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PMC10243817
IRIP-Seq was performed on BEAS-2B cells, and confirmation assay with RIP followed by RT-PCR was conducted on HNECs (67, 68).
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PMC11045125
Thus, Myc may also decrease STAT3 activity in human BL cells in vivo by decreasing their responsiveness to cytokines, including IL6, IL21 and IL10, and increasing expression of phosphatases that reverse STAT3 phosphorylation .
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PMC10551595
Cells were treated with GinA or 0.4% DMSO (as the control) according to cell doubling times.
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PMC11594641
A value of p < 0.05 was considered statistically significant and was marked on the figures as *.
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PMC9429973
We believe that delivery of Bortezomib through a weekly regime facilitates patients being able to maintain on Bortezomib longer and receive higher cumulative doses.
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PMC11190538
The maximum EE was measured for 1:1 formula (88.66 % ± 1.35), followed by 1:2 formulae (94.65 % ± 1.75) and the minimum with 1: 3 formulae (97.85 % ± 2.15).
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PMC11787381
Post-test significance is reported only for comparisons for which the ANOVA test was significant.
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PMC11047729
Moreover, it exhibits cytotoxic properties on AML K562 cells.
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PMC8728081
The morphology of Kajjali and Rasasindura treated larvae were observed under a stereomicroscope and no significant difference was observed.
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PMC9429973
In contrast, the IGLV3-21 genotype and trisomy 12 or loss of 17p13 were mutually exclusive (trisomy 12: 0% vs. 12%, P=0.008; del17p13: 0% vs. 12%, P=0.01).
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PMC11411131
In the presence of MeHg, a truncated TetR may lose its repressive function, thus elevating the luciferase signal.
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PMC11794847
The T cell metabolic discrepancies observed in the HVEM-deficient cells were largely rectified.
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PMC11545737
This process is associated with the loss of intracellular ATP in E. coli and K. pneumonieae infections.
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PMC9635307
Our results showed that CEACAM1 is more highly expressed in B cells compared to T cells within secondary lymphoid tissues, which is similar to observations in PB by others .
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PMC9429973
Aims: In this study, we investigated the regenerative effects of umbilical cord blood EPC-EVs on endothelial cells in vitro Methods: EPCs were obtained from human umbilical cord blood (UCB) and characterized by flow cytometry.
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PMC10093184
All tested cell lines were able to grow as multicellular spheroids.
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PMC10507284
To further understand the gene enrichment in STS, we conducted GO and KEGG pathway enrichment analysis given TROAP‐related genes using the clusterProfiler package.
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PMC9318744
Camostat mesylate, naphthofluorescein, E64d, and decanoyl-RVKR-CMK have been widely used to study the virus entry and spike processing by targeting host cell proteases .
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PMC11761919
Several probiotics have been developed as tools to deliver antigens, including lactiplantibacillus plantarum delivering epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Hwang et al., 2023), Lactococcus lactis expressing HA1 proteins of H9N2 virus and chicken IgY Fc fragment (HA1-IgYFc) fusion protein (Zhang et al., 2023), and Lactococcus lactis and Lactobacillus plantarum expressing M. bovis antigens MPB70 and MPB83 (Stedman et al., 2019).
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PMC8873393
Each bar represents the number of noncoding transcripts having a specific number of exons.
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PMC10452486
The HLA-I trimers (HC + B2m + bound peptide) present the peptide antigen to CD8+ Cytotoxic T Lymphocytes CTLs .
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PMC7090062
All data are representative of three independent experiments.
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PMC11045125
To confirm that ΔEBNA2 EBV-infected cord blood (CB) B cell lines lack EBNA2 expression, immunoblot analysis was performed in CB cells infected with ΔEBNA2 EBV.
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PMC9910796
The mouse mAb 17F.E10, previously described as an anti-p60/p37 antibody , has been re-characterized in the present study as a specific antibody to polyprotein pp62 (ORF CP530R) and its mature structural protein p35 by immunoblotting (S6 Fig), immunofluorescence (Fig 5B) and immuno-EM analyses (Fig 6C) of pp62-expressing Cos cells.
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PMC11770746
We tested whether they induce mechanical allodynia, heat hyperalgesia, cold allodynia, or spontaneous pain in mice.
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PMC11476264
To clarify the major types of transcription factors that induce EMT in lung cancer cells, we used nickel chloride (NiCl2) to induce EMT in human non-small cell lung cancer cell lines A549 and H1299.
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PMC11721064
The resulting cDNA underwent end repair, phosphorylation, and adenylation according to Illumina's library preparation protocol.
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