OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC8633974	For this, we used a dual approach to label nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", ",", "we", "used", "a", "dual", "approach", "to", "label", "nanop...
PMC9275501	Qi et al. (2018) developed a novel pH and redox dual-sensitive nanocarrier loaded with CUR and antitumor peptide (AP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Qi", ...
PMC9429973	Summary/Conclusion: In summary, DDX41-mutated myeloid neoplasms define a distinct entity of myelodysplasias associated with higher incidence of leukemic evolution and better responsiveness to hypomethylating agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7022782	This result suggests that the association of ICG to the NPs is determining for its internalization inside the cells, resulting in the concentration of ICG having evident green color inclusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4369959	Thus, zerumbone has a great potential for the treatment of liver cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "zerumbone", "has", "a", "great", "potential", "for", "th...
PMC11731614	By cross-referencing the miRDB, TargetScan v7, and DIANA-microT databases (Fig. 2B), the predicted protein targets of these small RNAs were used to run a KEGG enrichment analysis for let-7 and miR-23, with both revealing ‘Axon Guidance’ as a predicted target pathway (Fig. 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	Next, we were interested in whether the co-expression of AMPARs with SD4 results in a reciprocal increase in the cluster size of SD4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11721277	Therefore, this study aimed to investigate the effects of different injected doses on biodistribution in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "study", "aimed", ...
PMC8978939	Representative Western blot showing the expression of VHL protein in the tumors developed by 786-O, WT, P138R, and L163R cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC11476837	Drug resistance is one of the major obstacles to the clinical use of doxorubicin, an extensively used chemotherapeutic drug to treat various cancers, including leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7081114	The cells were stained using an Annexin V-APC/7-AAD Kit (eBioscience, Shanghai, China) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells...
PMC6889484	The plasmid DNA was extracted from the bacterial colonies using the NucleoSpin 8 Plasmid Kit (Clontech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plasmid", "DNA", "was", "extrac...
PMC11798926	Further mutation analysis, including the construction of SynDIG1/SynDIG2 chimeras, will be helpful in clarifying these complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "mutation", "analysis", ",", ...
PMC11534377	The cells were washed three times with PBS and then the nuclei were stained with DAPI (Abcam, Cambridge, UK) 100 μg/mL for 30 seconds, followed by another step of washing with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10758402	Unfortunately, not all cancers are sensitive and responsive to oncolytic virotherapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "not", "all", "cancers", "are", "sensitive", "and", "respon...
PMC10745221	To test this hypothesis, we wanted to compare protein arginine methylation levels in the previously described methionine-addicted parent and less methionine-dependent revertant cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10253973	Hence, compound 57 could be a luminescent marker of DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "compound", "57", "could", "be", "a", "luminescent", "marker", "of", ...
PMC11033180	∗p < 0.05 Kruskal-Wallis test, supplemented by Dunn’s post-hoc test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "<", "0.05", "Kruskal-Wallis", "test", ",", "supplemented", "by", "Dunn", ...
PMC11544122	These results provide novel insights into the mechanisms regulating GPCR trafficking and broaden our overall understanding of GPCR regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "provide", "no...
PMC11206502	At a 0.4 mg/mL HB concentration, 141 cells were positive for autophagy, with the highest frequency of cells with the coupled signals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11547972	Embedding both drugs into standard treatment protocols may, therefore, increase tumor response and delay tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Embedding", "both", "drugs", "into", "...
PMC11397654	In DLD-1 cells, the genes that code enzymes crucial to the proliferation of the cells are mutated, so their expression is much lower than it normally would be in healthy cells.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	MERTK antibody (MAB8912, R&D Systems, Minneapolis, MN, USA) was used for immunoprecipitation and phosphorylated MERTK (Y749, Y753, Y754; PhosphoSolutions, Aurora, CO, USA) and MERTK (ab52968, Abcam, Cambridge, UK) antibodies were used for immunoblotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Sustained MRD-negativity rates at 10 lasting ≥6 and ≥12 months were higher for D-RVd vs RVd among all high-risk subgroups (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sustain...
PMC11803149	Results are shown as mean tumor volume ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "shown", "as", "mean", "tumor", "volume", "±", "SEM", "." ] } ]
PMC9429973	Patients then entered a Part B open-label extension and received biweekly sutimlimab for up to 3 years (N=22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "then", "entered"...
PMC11806613	D Effects of OST-01 on oncogenic activities in TNBC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Effects", "of", "OST-01", "on", "oncogenic", "activities", "in", "TNBC", "cells", "."...
PMC11757230	To date, clinical trials in veterinary medicine have shown that MSCs have therapeutic effects in dogs with joint, spinal, neuromuscular, skin, gastrointestinal, and ocular diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315	Therefore, it can be concluded that aqueous extracts of Cinnamon induce apoptosis at these concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "can", "be", "concluded", ...
PMC11306019	In brief, RPMI8226 cells were seeded at a density of 2.5 × 10/mL. These cells were then treated with BTZ at a concentration of 3.125 nM in the presence or absence of GA at 1 μM, EGC at 0.73 µM, or EGCG at 0.17 µM on days 1, 4, 8, and 11.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	Furthermore, oxidative stress induced by ω-3 LCPUFAs could also regulate the signaling pathways related to ROS, such as MAPK, NF-κB or activator protein 1 transcription factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11419566	Taking Ribociclib may also result in neutropenia, mucositis, fatigue, gastrointestinal side effects, and even hepatobiliary toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taking", "Ribociclib", "may"...
PMC10631132	While several differentiation protocols have been published, it remains unclear which protocols or differentiation methods are preferable regarding the differentiation of osteoclasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While",...
PMC10165258	In the present study, we demonstrate a protocol to screen combination therapy on spheroids within an array of droplets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", ...
PMC9351137	Secondly, the defects observed after depletion of CRS in HeLa and Drosophila S2 cells do not seem to be simply a chaotic disruption of cell division caused by simultaneously misexpression of cell division genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10850553	p < 0.05. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ".", "(" ] } ]
PMC11699465	Our new foundings also imply that TMEM199 is involved in CD274 mRNA gene expression by the transcriptional regulation of the upstream transcription factors or cofactors of CD274, such as IFNGR1, IRF1, MTMR9, KAT8, and Trim28 (Figure 8).Figure 8Mechanism diagram of nuclear TMEM199 regulating PD-L1Diagram to show the cel...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	E. Urciuoli, E. Di Bona, S. Greve, A. De Vivo, S. Sica, R. Fontana, W. Barcellini, L. Marano, E. N. Oliva UOC Ematologia e Trapianto, AORN San Giuseppe Moscati, Avellino; UOC Oncoematologia, Azienda Ospedaliera Pedemontana,ASL 7, Bassano del Grappa (VI); U.O.C di Ematologia, Grande Ospedale Metropolitano Bianchi Melacr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	Decreased LGR5 inhibited clonogenicity and cell survival of colon cancer cells in vitroColorectalColon cancer cell lines: HCT116, RKO, FET, CBS, HCT116b, TENN CASC 15 overexpression promoted colon cancer cell proliferation by activating the WNT/β-catenin pathway by upregulating LGR5 expression through microRNA-4310Colo...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", ...
PMC11791432	It can be inferred that ANXA1 has the ability to promote tumor cell proliferation in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "be", "inferred", "that", "ANXA1", "...
PMC11653533	Abdullah Al Mamun: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	Treatment schedule.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Treatment", "schedule", "." ] } ]
PMC9429973	Enrollment began in September 2017 for Group 1 and 2 and June 2019 for Group 3, and is completed in all 3 groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11286266	MAGeCK-based analysis of sgRNAs enriched in cells with attenuated ATF6α signalling and intact activity of the IRE1 reporter, revealed that those targeting S1P and S2P proteases (encoding by the MBTPS1 and MBTPS2 genes) were the two most enriched genes (Figure 1C), validating the experimental methodology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545714	The product of ELOV4 is a fatty acid elongase, which elongates from C26‐CoA to C30‐CoA and beyond.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "product", "of", "ELOV4", "is", ...
PMC11585254	β-arrestins also mediate GPCR signaling by scaffolding effector molecules, such as mitogen-activated protein kinases and extracellular regulated kinases 1 and 2 (ERK1/2) (Gurevich and Gurevich, 2006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11139449	HITI provides a fast and cost-effective approach to genome editing across diverse applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HITI", "provides", "a", "fast", "and", "cost-effective", "approach", "to", ...
PMC9111184	Cytotoxicity studies were performed using the MTT viability test (Ressaissi et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "studies", "were", "performed", "using", ...
PMC11544122	g Analysis of SNX9 recruitment to the plasma membrane by BRET.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Analysis", "of", "SNX9", "recruitment", "to", "the", "plasma", "membrane", "by",...
PMC8873393	In this respect it is interesting to evaluate the impact of these active TSS sites after UV on the genome-wide processive transcription elongation after DNA repair.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11001582	b, Agarose gel shows generation of patient-length polyGR, using recursive directional ligation to sequentially double the repeat length up to 400 repeats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11186948	The following primers were used for RT-qPCR: HDAC2 5’-AGGCAAATACTATGCTGTC-3’ and 5’-TGAAACAACCCAGTCTATC-3’; TP53 5’-CTATGAGCCGAGGTTG-3’ and 5’-AGAGGAGCTGTGTTGG-3’; GAPDH 5’-AGCCACATCGCTCAGACAC-3’ and 5’-GCCCAATACGACCAAATCC-3’; RPLP0 5’-TCTACAACCCTGAAGTGCTTGAT-3’ and 5’-CAATCTGCAGACAGACACTGG-3’; RPL13A 5’-CCTGGAGGAGAAGA...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	Programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) interactions are targets for immunotherapies aimed to reinvigorate T cell function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Next, after correction for confounders variables, the 4-PI showed to be independently associated with prognosis, with an HR=3.94, 2.1, and 1.78 for TCGA, BeatAML, and HOVON cohorts, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11078693	Note: In this protocol, we use phalloidin at a final concentration 100 nM by a 1:100 dilution of a 10 μM stock solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	TP53 mutations and higher cytogenetic risk confer poor prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TP53", "mutations", "and", "higher", "cytogenetic", "risk", "confer", "poor", "prognosis", "." ] } ]
PMC11643361	Ligand modifications, including sulfur-containing heterocycles and unsubstituted pyrazoles, have proven effective in enhancing cytotoxicity and selectivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ligand", "modifications", ",", "including", ...
PMC10898159	Here, we summarize various of KIT variants and its core regulated network, focus on the process of gene regulation, transcription and protein translation, with emphasis on the therapeutical vulnerability and clinical strategy for targeting oncogenic KIT kinase dependency in GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	4Circulating TSP-1 is decreased after NACT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4Circulating", "TSP-1", "is", "decreased", "after", "NACT", "." ] } ]
PMC11437637	Detection of absolute lymphocyte counts in peripheral blood , named “Body Immune Function Test” : 1) Using the reverse pipetting technique, pipette 50 µl of well-mixed EDTA-K2 anticoagulant whole blood into the bottom of the absolute count microsphere tube.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These patients have poor OS and progress quickly through current therapies, suggesting poor progression-free survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "patients", "have", "poor", "OS", "and", ...
PMC11726183	As a unique class in drug design and discovery, isatin (1H-indole-2,3-dione) is one of the most advantageous scaffolds of heterocyclic systems, with a diversity of remarkable biological activities, such as antibacterial, anticonvulsant, and mostly anticancer properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	S1PR3 expression is markedly elevated in psoriatic lesions and correlates with disease severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S1PR3", "expression", "is", "markedly", "elevated", "in", "psoriatic", "les...
PMC11740207	Molecular mechanisms that control the switch between SD and AD in SCs are crucial for balancing SC SD with their differentiation into specialized cells (Knoblich, 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5443223	Results demonstrated that CEP164 is involved in the radiation-induced cellular response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "demonstrated", "that", "CEP164", "is", "involved", "in", "the", "radiation-induc...
PMC11684297	The results showed that in control cells, all the cells were green in color, whereas after ZnO-NF treatment, the number of dead cells (red) increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10956161	R-4.3.1 software for code visualization processing was used to show the gene expression in lung adenocarcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "R-4.3.1", "software", "for", "code", "visualization", ...
PMC9429973	RDI positively correlated with TRV (r = 0.53, p = 0.003), right MCA flow velocity (r = 0.45, p = 0.013) and left MCA flow velocity (r = 0.55, p = 0.002), while it showed negative correlation with BMI-SDS (r = -0.48, p = 0.008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In pts treated with ZANU, neutropenia and infection prevalence decreased over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "pts", "treated", "with", "ZANU", ",", "neutropenia", "and", "in...
PMC9429973	Relevant adverse events are shown in the Table.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relevant", "adverse", "events", "are", "shown", "in", "the", "Table", "." ] } ]
PMC9428827	No-alpha mutein behaves as an agonist with higher antitumor activity but lower toxicity than wtIL-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No-alpha", "mutein", "behaves", "as", "an", "agonist", "wit...
PMC6468656	Importantly, cancer metastasis is a complicated process with the involvement of multiple factors and genetic events which modulate several steps for initiating metastasis including tumor invasion at the primary site .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10809689	However, mTORC protein expression decreased significantly after 48 h (p = 0.04) (Fig. 5 (a., b.)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Ninety nine (42.1%) patients lived in industrial regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ninety", "nine", "(", "42.1", "%", ")", "patients", "lived", "in", "industrial", ...
PMC11371627	There was no family history for neuromuscular/neurological diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "family", "history", "for", "neuromuscular/neurological", "diseases", "." ] } ]
PMC11411004	Epigenetic regulation plays a central role in the regulation of a number of cellular processes such as proliferation, differentiation, cell cycle, and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11756514	This is crucial for protecting the host from microbial invasion (2, 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "crucial", "for", "protecting", "the", "host",...
PMC5311252	A striking exception from this general pattern was noticed in TGCT where the miR-371~373 cluster was dominating together with the miR-302~367 and C19MC clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11791478	This release disrupts essential cellular processes within cancer cells, leading to their targeted destruction (15, 16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "release", "disrupts"...
PMC11792766	The NRU assay indeed relies on the ability of viable cells to incorporate and bind the neutral red dye within lysosomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NRU", "ass...
PMC11469524	After quantile normalisation, differentially regulated sites were identified using the limma R package (v. 3.54.0) and resulting p-values were corrected for multiple testing using Benjamini-Hochberg method (FDR< = 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8567602	To investigate the alternate hypothesis, that degradation of CBAF drives its lower abundance in cells, LICOR quantitative WBs were performed for nuclear extracts from EXPI293 cells transfected to express either SS18–SSX or SS18 (n = 5, each), comparing the ratios in abundance of BAF-family components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11609529	Western blot analysis confirmed that both shM2-1 and shM2-3 reduced the expression of both the endogenous YM fusion and MAML2 (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Pairing multiplex-edited hHSPCs with subsequent multi-specific immunotherapy can obviate concerns around tumor heterogeneity and escape mechanisms related to single antigen downregulation, transforming the current treatment approach for AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	Furthermore, we also proposed the role of PUMA induction in facilitating a higher rate of cellular apoptosis, which can be useful in detecting chemosensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10706275	In Figure 8, the batch culture of the K1-HSA-18, K1-HSA-40, and K1-HSA-46 positive monoclonal strains is depicted over 60 generations at intervals of 0, 10, 20, 30, 40, 50, and 60 generations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	Because all the complexes were identified as cytotoxic inactive (IC50 ˃ 50.0 μM), we strived to investigate and explain the reasons of their inactivity by means of H NMR, ESI+ mass spectrometry and fluorescence studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674834	NAT1*4 is the most common reference allele .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NAT1", "*", "4", "is", "the", "most", "common", "reference", "allele", "." ] } ]
PMC11423992	Besides, the TFAB002s show potent pharmacodynamic activity in vivo in the WIL2-S cells CDX mouse model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "the", "TFAB002s", "show"...
PMC11122631	Subfraction C6 (136.1 mg) was subjected to silica gel CC eluted stepwise with hexanes/acetone/methanol (6/1/0 to 0/0/1), and three fractions (C6A–C6C) were obtained.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7519871	The most remarkable effects of cisplatin are changes in DNA conformation and damage induced by DNA-cisplatin adducts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "remarkable", "effects", "of", ...
PMC11806818	Electrochemical sensing has the advantages of low cost, simplicity, time saving and easy execution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electrochemical", "sensing", "has", "the", "advantages", ...
PMC10203589	With the in-depth study of the relationship between the structure, function and disease of FGFR, it can provide new treatment methods for a variety of neoplastic diseases and make it possible to conquer cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	The antineoplastic agent 33 (5 μM) was used as a reference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antineoplastic", "agent", "33", "(", "5", "μM", ")", "was", ...
PMC11643361	Dipodal ligands such as tridentate amines confer selective cytotoxicity and, in cobalt and vanadium complexes, modulate gene expression related to metastasis, indicating potential antimetastatic properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	The compounds were added to the cells to obtain final concentrations of 2 µM, 4 µM, and 8 µM for compound 2a, and 1 µM, 2 µM, and 4 µM for compound 2a-B. Camptothecin (Sigma Aldrich, St. Louis, MO, USA) was used as a positive control at a concentration of 15 µM. The first measurement was taken immediately after adding ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Viruses from round 6 (independent flasks a–f) were used to infect 100% CEM, 25% CEM:75% CEM/D128K, or 100% CEM/D128K cells, and viral supernatants were collected every 2 to 3 days for up to 28 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine"...
PMC8956657	Previous reports indicated that MERS-CoV ORF4b can inhibit the innate immune response by blocking NF-κB signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "reports", "indicated", "that", "MERS-CoV", ...
PMC11683240	The bar graph (A) shows the quantification of Western blot signals from three independent experiments, while (B) shows blots of a representative experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Therefore, this consideration must be taken in account when further designing new CoCp-based complexes as anticancer agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "consideration", ...

PMC8633974

For this, we used a dual approach to label nanoparticles.

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PMC9275501

Qi et al. (2018) developed a novel pH and redox dual-sensitive nanocarrier loaded with CUR and antitumor peptide (AP).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Qi", ...

PMC9429973

Summary/Conclusion: In summary, DDX41-mutated myeloid neoplasms define a distinct entity of myelodysplasias associated with higher incidence of leukemic evolution and better responsiveness to hypomethylating agents.

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PMC7022782

This result suggests that the association of ICG to the NPs is determining for its internalization inside the cells, resulting in the concentration of ICG having evident green color inclusions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4369959

Thus, zerumbone has a great potential for the treatment of liver cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "zerumbone", "has", "a", "great", "potential", "for", "th...

PMC11731614

By cross-referencing the miRDB, TargetScan v7, and DIANA-microT databases (Fig. 2B), the predicted protein targets of these small RNAs were used to run a KEGG enrichment analysis for let-7 and miR-23, with both revealing ‘Axon Guidance’ as a predicted target pathway (Fig. 4C).

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PMC9024365

Next, we were interested in whether the co-expression of AMPARs with SD4 results in a reciprocal increase in the cluster size of SD4.

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PMC11721277

Therefore, this study aimed to investigate the effects of different injected doses on biodistribution in vivo.

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PMC8978939

Representative Western blot showing the expression of VHL protein in the tumors developed by 786-O, WT, P138R, and L163R cell lines.

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PMC11476837

Drug resistance is one of the major obstacles to the clinical use of doxorubicin, an extensively used chemotherapeutic drug to treat various cancers, including leukemia.

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PMC7081114

The cells were stained using an Annexin V-APC/7-AAD Kit (eBioscience, Shanghai, China) according to the manufacturer’s instructions.

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PMC6889484

The plasmid DNA was extracted from the bacterial colonies using the NucleoSpin 8 Plasmid Kit (Clontech).

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PMC11798926

Further mutation analysis, including the construction of SynDIG1/SynDIG2 chimeras, will be helpful in clarifying these complications.

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PMC11534377

The cells were washed three times with PBS and then the nuclei were stained with DAPI (Abcam, Cambridge, UK) 100 μg/mL for 30 seconds, followed by another step of washing with PBS.

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PMC10758402

Unfortunately, not all cancers are sensitive and responsive to oncolytic virotherapy.

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PMC10745221

To test this hypothesis, we wanted to compare protein arginine methylation levels in the previously described methionine-addicted parent and less methionine-dependent revertant cell lines.

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PMC10253973

Hence, compound 57 could be a luminescent marker of DNA.

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PMC11033180

∗p < 0.05 Kruskal-Wallis test, supplemented by Dunn’s post-hoc test.

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PMC11544122

These results provide novel insights into the mechanisms regulating GPCR trafficking and broaden our overall understanding of GPCR regulation.

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PMC11206502

At a 0.4 mg/mL HB concentration, 141 cells were positive for autophagy, with the highest frequency of cells with the coupled signals.

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PMC11547972

Embedding both drugs into standard treatment protocols may, therefore, increase tumor response and delay tumor progression.

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PMC11397654

In DLD-1 cells, the genes that code enzymes crucial to the proliferation of the cells are mutated, so their expression is much lower than it normally would be in healthy cells.

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PMC11352666

MERTK antibody (MAB8912, R&D Systems, Minneapolis, MN, USA) was used for immunoprecipitation and phosphorylated MERTK (Y749, Y753, Y754; PhosphoSolutions, Aurora, CO, USA) and MERTK (ab52968, Abcam, Cambridge, UK) antibodies were used for immunoblotting.

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PMC9429973

Sustained MRD-negativity rates at 10 lasting ≥6 and ≥12 months were higher for D-RVd vs RVd among all high-risk subgroups (Table).

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PMC11803149

Results are shown as mean tumor volume ± SEM.

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PMC9429973

Patients then entered a Part B open-label extension and received biweekly sutimlimab for up to 3 years (N=22).

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PMC11806613

D Effects of OST-01 on oncogenic activities in TNBC cells.

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PMC11757230

To date, clinical trials in veterinary medicine have shown that MSCs have therapeutic effects in dogs with joint, spinal, neuromuscular, skin, gastrointestinal, and ocular diseases .

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PMC9388315

Therefore, it can be concluded that aqueous extracts of Cinnamon induce apoptosis at these concentrations.

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PMC11306019

In brief, RPMI8226 cells were seeded at a density of 2.5 × 10/mL. These cells were then treated with BTZ at a concentration of 3.125 nM in the presence or absence of GA at 1 μM, EGC at 0.73 µM, or EGCG at 0.17 µM on days 1, 4, 8, and 11.

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PMC11742864

Furthermore, oxidative stress induced by ω-3 LCPUFAs could also regulate the signaling pathways related to ROS, such as MAPK, NF-κB or activator protein 1 transcription factors.

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PMC11419566

Taking Ribociclib may also result in neutropenia, mucositis, fatigue, gastrointestinal side effects, and even hepatobiliary toxicity.

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PMC10631132

While several differentiation protocols have been published, it remains unclear which protocols or differentiation methods are preferable regarding the differentiation of osteoclasts.

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PMC10165258

In the present study, we demonstrate a protocol to screen combination therapy on spheroids within an array of droplets.

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PMC9351137

Secondly, the defects observed after depletion of CRS in HeLa and Drosophila S2 cells do not seem to be simply a chaotic disruption of cell division caused by simultaneously misexpression of cell division genes.

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PMC10850553

p < 0.05. (

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PMC11699465

Our new foundings also imply that TMEM199 is involved in CD274 mRNA gene expression by the transcriptional regulation of the upstream transcription factors or cofactors of CD274, such as IFNGR1, IRF1, MTMR9, KAT8, and Trim28 (Figure 8).Figure 8Mechanism diagram of nuclear TMEM199 regulating PD-L1Diagram to show the cel...

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PMC9429973

E. Urciuoli, E. Di Bona, S. Greve, A. De Vivo, S. Sica, R. Fontana, W. Barcellini, L. Marano, E. N. Oliva UOC Ematologia e Trapianto, AORN San Giuseppe Moscati, Avellino; UOC Oncoematologia, Azienda Ospedaliera Pedemontana,ASL 7, Bassano del Grappa (VI); U.O.C di Ematologia, Grande Ospedale Metropolitano Bianchi Melacr...

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PMC11742290

Decreased LGR5 inhibited clonogenicity and cell survival of colon cancer cells in vitroColorectalColon cancer cell lines: HCT116, RKO, FET, CBS, HCT116b, TENN CASC 15 overexpression promoted colon cancer cell proliferation by activating the WNT/β-catenin pathway by upregulating LGR5 expression through microRNA-4310Colo...

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PMC11791432

It can be inferred that ANXA1 has the ability to promote tumor cell proliferation in vivo.

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PMC11653533

Abdullah Al Mamun: Writing – review & editing, Writing – original draft, Visualization, Validation, Supervision, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization.

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PMC11185260

Treatment schedule.

[ { "tags": [ "O", "O", "O" ], "tokens": [ "Treatment", "schedule", "." ] } ]

PMC9429973

Enrollment began in September 2017 for Group 1 and 2 and June 2019 for Group 3, and is completed in all 3 groups.

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PMC11286266

MAGeCK-based analysis of sgRNAs enriched in cells with attenuated ATF6α signalling and intact activity of the IRE1 reporter, revealed that those targeting S1P and S2P proteases (encoding by the MBTPS1 and MBTPS2 genes) were the two most enriched genes (Figure 1C), validating the experimental methodology.

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PMC9545714

The product of ELOV4 is a fatty acid elongase, which elongates from C26‐CoA to C30‐CoA and beyond.

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PMC11585254

β-arrestins also mediate GPCR signaling by scaffolding effector molecules, such as mitogen-activated protein kinases and extracellular regulated kinases 1 and 2 (ERK1/2) (Gurevich and Gurevich, 2006).

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PMC11139449

HITI provides a fast and cost-effective approach to genome editing across diverse applications.

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PMC9111184

Cytotoxicity studies were performed using the MTT viability test (Ressaissi et al., 2017).

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PMC11544122

g Analysis of SNX9 recruitment to the plasma membrane by BRET.

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PMC8873393

In this respect it is interesting to evaluate the impact of these active TSS sites after UV on the genome-wide processive transcription elongation after DNA repair.

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PMC11001582

b, Agarose gel shows generation of patient-length polyGR, using recursive directional ligation to sequentially double the repeat length up to 400 repeats.

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PMC11186948

The following primers were used for RT-qPCR: HDAC2 5’-AGGCAAATACTATGCTGTC-3’ and 5’-TGAAACAACCCAGTCTATC-3’; TP53 5’-CTATGAGCCGAGGTTG-3’ and 5’-AGAGGAGCTGTGTTGG-3’; GAPDH 5’-AGCCACATCGCTCAGACAC-3’ and 5’-GCCCAATACGACCAAATCC-3’; RPLP0 5’-TCTACAACCCTGAAGTGCTTGAT-3’ and 5’-CAATCTGCAGACAGACACTGG-3’; RPL13A 5’-CCTGGAGGAGAAGA...

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PMC11777207

Programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) interactions are targets for immunotherapies aimed to reinvigorate T cell function.

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PMC9429973

Next, after correction for confounders variables, the 4-PI showed to be independently associated with prognosis, with an HR=3.94, 2.1, and 1.78 for TCGA, BeatAML, and HOVON cohorts, respectively.

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PMC11078693

Note: In this protocol, we use phalloidin at a final concentration 100 nM by a 1:100 dilution of a 10 μM stock solution.

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PMC9429973

TP53 mutations and higher cytogenetic risk confer poor prognosis.

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PMC11643361

Ligand modifications, including sulfur-containing heterocycles and unsubstituted pyrazoles, have proven effective in enhancing cytotoxicity and selectivity.

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PMC10898159

Here, we summarize various of KIT variants and its core regulated network, focus on the process of gene regulation, transcription and protein translation, with emphasis on the therapeutical vulnerability and clinical strategy for targeting oncogenic KIT kinase dependency in GIST.

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PMC11323699

4Circulating TSP-1 is decreased after NACT.

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PMC11437637

Detection of absolute lymphocyte counts in peripheral blood , named “Body Immune Function Test” : 1) Using the reverse pipetting technique, pipette 50 µl of well-mixed EDTA-K2 anticoagulant whole blood into the bottom of the absolute count microsphere tube.

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PMC9429973

These patients have poor OS and progress quickly through current therapies, suggesting poor progression-free survival.

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PMC11726183

As a unique class in drug design and discovery, isatin (1H-indole-2,3-dione) is one of the most advantageous scaffolds of heterocyclic systems, with a diversity of remarkable biological activities, such as antibacterial, anticonvulsant, and mostly anticancer properties.

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PMC11746942

S1PR3 expression is markedly elevated in psoriatic lesions and correlates with disease severity.

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PMC11740207

Molecular mechanisms that control the switch between SD and AD in SCs are crucial for balancing SC SD with their differentiation into specialized cells (Knoblich, 2010).

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PMC5443223

Results demonstrated that CEP164 is involved in the radiation-induced cellular response.

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PMC11684297

The results showed that in control cells, all the cells were green in color, whereas after ZnO-NF treatment, the number of dead cells (red) increased.

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PMC10956161

R-4.3.1 software for code visualization processing was used to show the gene expression in lung adenocarcinoma.

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PMC9429973

RDI positively correlated with TRV (r = 0.53, p = 0.003), right MCA flow velocity (r = 0.45, p = 0.013) and left MCA flow velocity (r = 0.55, p = 0.002), while it showed negative correlation with BMI-SDS (r = -0.48, p = 0.008).

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PMC9429973

In pts treated with ZANU, neutropenia and infection prevalence decreased over time.

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PMC9429973

Relevant adverse events are shown in the Table.

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PMC9428827

No-alpha mutein behaves as an agonist with higher antitumor activity but lower toxicity than wtIL-2.

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PMC6468656

Importantly, cancer metastasis is a complicated process with the involvement of multiple factors and genetic events which modulate several steps for initiating metastasis including tumor invasion at the primary site .

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PMC10809689

However, mTORC protein expression decreased significantly after 48 h (p = 0.04) (Fig. 5 (a., b.)).

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PMC9429973

Ninety nine (42.1%) patients lived in industrial regions.

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PMC11371627

There was no family history for neuromuscular/neurological diseases.

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PMC11411004

Epigenetic regulation plays a central role in the regulation of a number of cellular processes such as proliferation, differentiation, cell cycle, and apoptosis.

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PMC11756514

This is crucial for protecting the host from microbial invasion (2, 3).

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PMC5311252

A striking exception from this general pattern was noticed in TGCT where the miR-371~373 cluster was dominating together with the miR-302~367 and C19MC clusters.

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PMC11791478

This release disrupts essential cellular processes within cancer cells, leading to their targeted destruction (15, 16).

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PMC11792766

The NRU assay indeed relies on the ability of viable cells to incorporate and bind the neutral red dye within lysosomes.

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PMC11469524

After quantile normalisation, differentially regulated sites were identified using the limma R package (v. 3.54.0) and resulting p-values were corrected for multiple testing using Benjamini-Hochberg method (FDR< = 0.05).

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PMC8567602

To investigate the alternate hypothesis, that degradation of CBAF drives its lower abundance in cells, LICOR quantitative WBs were performed for nuclear extracts from EXPI293 cells transfected to express either SS18–SSX or SS18 (n = 5, each), comparing the ratios in abundance of BAF-family components.

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PMC11609529

Western blot analysis confirmed that both shM2-1 and shM2-3 reduced the expression of both the endogenous YM fusion and MAML2 (Figure 4A).

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PMC9429973

Pairing multiplex-edited hHSPCs with subsequent multi-specific immunotherapy can obviate concerns around tumor heterogeneity and escape mechanisms related to single antigen downregulation, transforming the current treatment approach for AML.

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PMC8526701

Furthermore, we also proposed the role of PUMA induction in facilitating a higher rate of cellular apoptosis, which can be useful in detecting chemosensitivity.

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PMC10706275

In Figure 8, the batch culture of the K1-HSA-18, K1-HSA-40, and K1-HSA-46 positive monoclonal strains is depicted over 60 generations at intervals of 0, 10, 20, 30, 40, 50, and 60 generations.

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PMC4659567

Because all the complexes were identified as cytotoxic inactive (IC50 ˃ 50.0 μM), we strived to investigate and explain the reasons of their inactivity by means of H NMR, ESI+ mass spectrometry and fluorescence studies.

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PMC11674834

NAT1*4 is the most common reference allele .

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PMC11423992

Besides, the TFAB002s show potent pharmacodynamic activity in vivo in the WIL2-S cells CDX mouse model.

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PMC11122631

Subfraction C6 (136.1 mg) was subjected to silica gel CC eluted stepwise with hexanes/acetone/methanol (6/1/0 to 0/0/1), and three fractions (C6A–C6C) were obtained.

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PMC7519871

The most remarkable effects of cisplatin are changes in DNA conformation and damage induced by DNA-cisplatin adducts.

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PMC11806818

Electrochemical sensing has the advantages of low cost, simplicity, time saving and easy execution.

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PMC10203589

With the in-depth study of the relationship between the structure, function and disease of FGFR, it can provide new treatment methods for a variety of neoplastic diseases and make it possible to conquer cancer.

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PMC9841531

The antineoplastic agent 33 (5 μM) was used as a reference.

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PMC11643361

Dipodal ligands such as tridentate amines confer selective cytotoxicity and, in cobalt and vanadium complexes, modulate gene expression related to metastasis, indicating potential antimetastatic properties.

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PMC11767817

The compounds were added to the cells to obtain final concentrations of 2 µM, 4 µM, and 8 µM for compound 2a, and 1 µM, 2 µM, and 4 µM for compound 2a-B. Camptothecin (Sigma Aldrich, St. Louis, MO, USA) was used as a positive control at a concentration of 15 µM. The first measurement was taken immediately after adding ...

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PMC6889484

Viruses from round 6 (independent flasks a–f) were used to infect 100% CEM, 25% CEM:75% CEM/D128K, or 100% CEM/D128K cells, and viral supernatants were collected every 2 to 3 days for up to 28 days.

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PMC8956657

Previous reports indicated that MERS-CoV ORF4b can inhibit the innate immune response by blocking NF-κB signaling.

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PMC11683240

The bar graph (A) shows the quantification of Western blot signals from three independent experiments, while (B) shows blots of a representative experiment.

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PMC10988555

Therefore, this consideration must be taken in account when further designing new CoCp-based complexes as anticancer agents.

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