OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9895440	Serum was collected from mice from the tail once a week into Monovette 200 Z-Gel (Sarstedt, Cat Nr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serum", "was", "collected", ...
PMC11585565	Individual data points are shown with means and standard errors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Individual", "data", "points", "are", "shown", "with", "means", "and", "standard", "errors", ...
PMC11461833	The LaminA/C expression level was measured by western blotting with an anti-Lamin A/C antibody, and a graph was generated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LaminA/C", ...
PMC11402217	= 471.18 g/mol, cLogP = 3.47, Figure 1A) emerging as the most effective against OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "=", "471.18", "g/mol", ",", "cLogP", ...
PMC11767725	These cytokines create an inflammatory milieu that disrupts microbial homeostasis, favoring pathogenic taxa like Staphylococcus aureus and Streptococcus pyogenes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cytokines", "create...
PMC9621239	Additionally, 5 of 24 patients with HCC in this study were found to be co-infected with HBV of multiple genotypes based on the HBV X gene (Figure 1G-K), which made it possible to investigate the distribution trend of different HBV genotypes in the liver tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	Interestingly, BCAT1-depleted cells showed pronounced sensitivity to DNA-damaging agents such as etoposide; however, how BCAT1 regulates this sensitivity remains uncertain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...
PMC11638255	Moreover, we have confirmed that TETA is a highly effective, non-toxic, and specific copper chelating agent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "we", "have", ...
PMC11419566	PA inhibited CYP2C9 activity in rat liver microsomes in this experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PA", "inhibited", "CYP2C9", "activity", "in", "rat", "liver", "microsomes", "in", "th...
PMC10965680	Among the immune response-related genes screened, DOCK8 was investigated for its ability to confer immunity as a positively selected gene in Yunling goats (Kim et al., 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	Increased and broadening tropism for various cell types will, however, bear invariable risk of accumulation in non-tumor-bearing tissue so extra care should be given to the use of attenuated OVs with strictly limited pathogenicity to normal tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	DIC was present in 2 patients (20%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DIC", "was", "present", "in", "2", "patients", "(", "20", "%", ")", "." ] } ]
PMC11766332	In the end, study miRNAs were selected according with the following inclusion criteria: miRNAs (1) reported to be deregulated in at least two independent studies (ASD-miRNAs) and (2) identified in a cellular context (i.e., lymphoblastoid cell line, frontal cortex, cerebellar cortex).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Further research studies are needed to improve screening, diagnosis, and management of IDA in this patient population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "research", "studies", ...
PMC11742290	These findings suggest that LGR5 expression may modulate the Wnt/β-catenin pathway to varying extents based on hormone receptor status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "t...
PMC11352746	In a Google Scholar search of twelve live-cell imaging devices and the publications that utilize them in neuroscience, it was discovered that Leica microscopes were the most frequently used imaging devices among the twelve.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	TDT patients suffer from chronic anaemia and the effects of iron overload despite chelation therapy, both of which result in significant morbidity and lead to premature mortality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	The demographic traits of participants were collected and the habitual dietary information was collected using a validated food frequency questionnaire.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "demographic", "traits...
PMC11790599	This study reveals a novel link between NRF2 activation and catastrophic macropinocytosis in breast cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "reveals", "a", "novel", "l...
PMC11507371	Even though the outcomes of initial clinical trials targeting head and neck SCC show signs of the effectiveness and safety of CAP , the untapped potential that a deep comprehension of the definite CAP-triggered intracellular mechanisms harbours should not be underestimated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There is no study comparing different DOAC for CVT treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "no", "study", "comparing", "different", "DOAC", "for", "CVT", "treatment", ...
PMC11612794	The predicted structure of chicken Mis12C comprised two head domains (Head1: composed of Mis12 and Pmf1; and Head2: composed of Dsn1 and Nsl1) connected to a coiled-coil stalk domain, which is composed of Mis12, Pmf1, Dsn1, and Nsl1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	Effect of imatinib on drug sensitivity of GIST882 cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "imatinib", "on", "drug", "sensitivity", "of", "GIST882", "cell", ...
PMC10761218	A viscous semisolid mass was produced using a rotary evaporator to concentrate the extract under reduced pressure at 40°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "viscous", "s...
PMC7887261	The sporadic LC patients were selected from our previous WES study, including samples from the HSPH, Baylor College of Medicine (BCM), and MD Anderson Cancer Center (MDACC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8728081	The surface elemental analysis was conducted by X-ray Photoelectron Spectroscopy (XPS, Kratos Analytical, Japan) equipped with a monochromatic X-ray source of 1486.6 eV. The peak position (binding energies) was calibrated with a standard gold peak (Au 4f7/2) at a position of 83.95 eV. The XPS peaks were analyzed and de...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	PTMs affect microtubule dynamics, organization, and interactions with other cellular components and process occurs in tubulin dimers, including α-tubulin and β-tubulin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11064533	The Datsenko-Wanner recombineering method was applied with minor modifications for gene deletion of flgH and spy genes (32).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Datsenko-Wanner", "re...
PMC11706776	Cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM, Lonza, Basel, Switzerland) or in Rosewell Park Memorial Institute Medium (Lonza), supplemented with 10% Fetal Bovin Serum (FBS, Lonza).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	The scaffold architecture type showed differences for the A2780 cell line—spheroid scaffolds were a hit for forming 3D cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scaffol...
PMC11791478	C, Late-intervention model with a single dose of XB002.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "Late-intervention", "model", "with", "a", "single", "dose", "of", "XB002", "." ...
PMC11740508	S1200, SelleckChem®) or carrier given by intraperitoneal (IP) injection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "S1200", ",", "SelleckChem", "®", ")", "or", "carrier", "given", ...
PMC11541409	GOF mutations in PDGFRA, while less frequent (about 5%) than KIT mutations, have a similar mutation pattern like KIT mutants in GISTs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Humans can be exposed to MC-LR from recreational activities, drinking water, fish, shellfish, vegetables, and dietary supplements made from algae .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8270637	Forward: 5’- CCTCACATCTCTGAGACCCG -3’ Reverse: 5’- CCGAAGCGAGGCTAGAAACC -3’ (PD-1 promoter); Forward: 5’- GAGGACCCTTGTACTCCAGGAA -3’ Reverse: 5’- CGAAAAGACAACCTCAAGCACTC -3’ (CTLA-4 promoter).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10667689	Currently, there are a few studies about the possible role of TIM-3 in metabolic reprogramming.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "there", "are", "a", "few", "st...
PMC11291490	n = 3).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", ")", "." ] } ]
PMC11317131	By targeting att sites to the genome using technologies such as prime editing, integrases can target safe loci while avoiding double-strand breaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", ...
PMC11533140	Thus, compound 17p had favorable pharmacokinetic properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "compound", "17p", "had", "favorable", "pharmacokinetic", "properties", "." ] } ]
PMC11387401	Thicker connectors correspond to interactions with higher interaction scores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thicker", "connectors", "correspond", "to", "interactions", "with", "higher", "interaction", "scores", "." ...
PMC9352806	For thrashing frequency of the head, the head of worms from one side to the other and then back within 1 min on clean NGM was recorded under a stereo microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Both GSIs increased ChgA expression, and this effect was slightly potentiated in the presence of the MAP4K4 inhibitor (K-L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "GSIs...
PMC11682172	More than 30% of patients suffering from common cancers will develop brain metastatic disease and incidences are rising.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "than", "30", "%", "...
PMC11409031	After that, cDNA synthesis was performed with HiScript II SuperMix (Vazyme, China) using 500 ng of RNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", "...
PMC11461833	Co-IP was performed as previously reported .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-IP", "was", "performed", "as", "previously", "reported", "." ] } ]
PMC11678130	Moreover, melanomas shelter important alterations in functional genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "melanomas", "shelter", "important", "alterations", "in", "functional", "genes", "." ] ...
PMC11670954	Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on day 22. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Y-27632", "collaborated", "wit...
PMC10955424	This study is a follow-up to our earlier research that showed how a TME component promotes OC chemoresistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "is", "a", "follow-up"...
PMC11659734	However, the lack of a significant increase in the Lys signal indicated that, despite the presence of oxidative damage, direct DNA strand breaks could not be as pronounced at the tested concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Transfected cells were lysed in RIPA buffer (140 mM NaCl, 10 mM Tris-HCl pH 8.0, 1 mM EDTA pH 8.0, 1.0% Triton X-100, 0.1% SDS, and 0.1% sodium deoxycholate) supplemented with Protease Inhibitor Cocktail COMPLETE EDTA-Free (Roche, 11873580001) and Phosphatase Inhibitor Cocktail Set II (Millipore, 524625) for 30 min at ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: 12 out of 67 children (17.9%) had allergy in our cohort, representing 16 episodes of varying severity (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11640419	Oleanolic acid (OA) is one of the most prevalent pentacyclic triterpenoids in nature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oleanolic", "acid", "(", "OA", ")", "is", "one", "of"...
PMC11635087	Considering future applications, we speculated that chloroplasts incorporated into animal cells may remain stable and continuously produce energy regardless of environmental conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conside...
PMC10490530	pcDNA3.1-CMV-hLuz plasmid was synthesized using GeneArt (ThermoFisher) service.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pcDNA3.1-CMV-hLuz", "plasmid", "was", "synthesized", "using", "GeneArt", "(", "ThermoFisher", ")", ...
PMC9429973	Acalabrutinib is a highly selective, potent, covalent BTK inhibitor that demonstrated less toxicity and improved tolerability in a head-to-head trial versus ibrutinib in chronic lymphocytic leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11402217	Protein expression levels of DKK1 and β-catenin were evaluated by probing with corresponding antibodies on the sections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "expression", "levels", "of", "DKK1", ...
PMC11082662	In this study, we aimed to identify target genes that are markedly upregulated in ovarian cancer and associated with poor prognosis through bioinformatics analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7917457	Oncolytic potency of VALO-D102 is identical to the parental strain and is not affected by coating the virus with tumor antigens (A–E) Oncolytic potency of VALO-D102 and PeptiCRAd-1, a cancer vaccine platform consisting of VALO-D102 coated with two modified tumor antigens, was compared to the Ad5/3-D24 parental strain i...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741577	Wound closure was measured, and tissue regeneration was assessed using hematoxylin and eosin staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wound", "closure", "was", "measured", ",", "and", "tissue",...
PMC11534035	Colony size is reduced after SERPINE1/PAI1 knockdown in VSCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colony", "size", "is", "reduced", "after", "SERPINE1/PAI1", "knockdown", "in", "VSCC", "." ] } ]
PMC10761571	Also, the CASP8 and BAX genes were upregulated by 2.49 and 2.8 folds, respectively, while a downregulation by 0.75 folds was noticed for the BCL2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11228511	In Lmnb1 cells with a nuclear bleb (n = 156), 90.2% had an abnormal lamin A meshwork; in cells without a nuclear bleb (n = 129), 43.9% had an abnormal lamin A meshwork (Fig. 7D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4816271	Phusion polymerase, quick Ligase and NEB5alpha (New England Biolabs, New England) were used for molecular cloning.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phusion", "polymerase", ",",...
PMC9429973	Rather, DR to ≤95% of actual weight-based dose, has been shown to result in shortened overall survival (OS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rather"...
PMC9429973	Results: EZH2 mRNA level was significantly increased in 53 newly diagnosed patients with AML compared to 20 healthy bone marrow control(p<0.0001)(Fig.1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results...
PMC11060216	Both TTF-1 and NapsinA were expressed and the total score in all 15 samples were more than 4 (P>0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "TTF-1", "...
PMC10975211	The authors synthesized the D-stereoisomeric form of buforin IIb that was reacted with a malonate-type linker to obtain an O,O’-bidentate linker that was further complexed with cis-[Pt(NH3)2(H2O)2] to produce cis-[Pt(NH3)2(malBuf–2H)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	According to those, dusCD40L was incorporated into the TMUV prM-E DNA vaccine with P2A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "those", ",", "dusCD40L", "was", "incorpo...
PMC11747949	After 48‐h incubation in 1% or 21% O2, supernatants were collected from the top or bottom chambers, centrifuged 300 × g for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Substrates of OMA1 include the mitochondrial GTPase OPA1 and DELE1, a mitochondrial protein recently shown to act as a sensor of mitochondrial dysfunction and to signal through HRI kinase and ATF4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Quercetin treated cells displayed 100-fold reduction in telomerase activity when compared to vehicle control while cells treated with combination of MST-312 and quercetin displayed 1000-fold reduction in telomerase activity when compared to the vehicle control (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11180402	It has been reported that miR-129 is downregulated in breast cancer , colorectal cancer , gastric cancer , and pancreatic cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been...
PMC8526701	Tumor volume at indicated time points after treatment was calculated and plotted with p values for indicated comparisons, n = 6 in each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Summary/Conclusion: Treatment with RUX and POM was safe and feasible in our study of advanced MF with an adverse genetic profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion...
PMC8427838	This assay also showed that moesin binds to TMIGD1 (Fig. 1D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "assay", "also", "showed", "that", "moesin", "binds", "to", "T...
PMC9143157	The patient has recorded no evidence of disease relapse for eight years .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "has", "recorded", "no", "evidence", "of", "disease", "relapse"...
PMC8382973	In rabbits treated with 100 mg/day SDS, epithelial disruption and vascular congestion were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "rabbits", "treated", "with", "100", "mg/day", "SDS", ...
PMC11704135	These properties highlight their potential as targeted therapies against various types of cancers, although further research and clinical trials are necessary to fully explore their efficacy and optimize their therapeutic potential.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Although myeloid cells have been historically associated with an immunosuppressive phenotype in neuroblastoma, recent investigations into subset diversity have revealed a heterogeneous range of microenvironment-dependent populations (reviewed in ref. ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A meta-analysis concluded that APLA were detected in nearly half of hospitalized patients with COVID-19, and even higher prevalence was found in patients with severe disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	In early-stage cancer, TGFβ inhibits cell proliferation, induces apoptosis, and maintains tissue homeostasis by promoting differentiation and reducing inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "early-...
PMC10577955	Thin-layer chromatography (TLC) was performed on silica gel GF254 precoated plates (Fluka, Steinheim, Germany) using the following solvent systems: n-Hexane: ethyl acetate (8:2 and 7:3 v/v).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739504	To evaluate the role in ciliogenesis in vitro, Kat2b-depleted NIH/3T3 cells were generated using short hairpin RNA (shRNA) against Kat2b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10968586	A similar growth inhibition was also obtained for MCF-7 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", "similar", "growth", "inhibition", "was", "also", "obtained", "for", "MCF-7", "cell...
PMC6803987	The plates were read directly at 450 nm with a microplate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plates", "were", "read", "directly", "at", "450", "nm", "with", "a"...
PMC11541241	In addition, we present disease control strategies using this pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "present", "disease", "control", "strategies", "using", "...
PMC11286266	Disruption of endogenous cgATF6α in XC45-6S cells by CRISPR/Cas9 genome editing abolished the responsiveness of the BiP::sfGFP reporter to ER stress and derepressed IRE1 signalling, both basally and in response to ER stress.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	Vaccination using two subtypes of mRNA-based vaccines, BNT162b2 or mRNA-1273, is an effective public health measure to reduce the risk of infection and severe complications from COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9776316	Moreover, the specific mutation of binding site 2 abrogated the increased XRCC4 luciferase activity by the cJUN overexpression in both the A2780cisR and SKOV3cisR cell lines, suggesting that cJUN specifically binds to the S2 site (−698~−692) in the XRCC4 promoter sequence to drive its transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC11388384	All experiments in which conditioned medium was used included an equal fraction of conditioned media, mixing SCUBE1-containing conditioned media with wild-type conditioned media to achieve the stated SCUBE1 conditioned media fraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Enediyne can be divided into two subfamilies: Cal-like enediyne and anthraquinone fusion enediyne.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enediyne", "can", "be", "divided", "into", "two", "subfamilies", ...
PMC11092418	Data analysis was performed using Calcusyn software (Biosoft, UK) and interpreted as follow: < 0.9 = synergistic effect, 0.9 - 1.1 = additive effect, > 1.1 = antagonistic effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10024132	γ9δ2 T cells were expanded from PBMCs for 17 days and then isolated for adoptive transfer. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "γ9δ2", "T", "cells", "were", "expanded", "f...
PMC10218459	The IC50 of the cytostatics was reduced depending on the duration of CPP treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "of", "the", "cytostatics", "was", "reduced", "dep...
PMC11377827	We validated the findings of the HIF activator screen in two non-cancer cell lines, HKC-8 (renal tubular epithelial cells) and RPE-1 (retinal pigment epithelial cells), where HIF responses have been well-validated (Cristante et al, 2023; Smythies et al, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "...
PMC9268183	One of them is Silybum marianum, a very well-studied plant , which is indeed a great example to illustrate the importance of common plants for cancer research in particular, and for medicine in general.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	To assess tumor uptake and study the effect of dose on the biodistribution, mice bearing A-431 xenografts were injected intravenously into the tail vein with 1.2 mg/kg (30 µg/mouse, 60 kBq), 6 mg/kg (150 µg/mouse, 60 kBq), and 12 mg/kg (300 µg/mouse, 60 kBq) of [Tc]Tc-HYNIC-Chl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	This study uncovered the essential roles of NAT10 and ac4C modification in osteosarcoma and identified NAT10 inhibitors through virtual screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "uncovered",...
PMC11762280	ns not significant.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "ns", "not", "significant", "." ] } ]
PMC10812665	This “reductive stress” (= increased NADH/NAD ratio) leads to a reversal of several metabolite balances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "“", "reductive", "stress", "”"...

PMC9895440

Serum was collected from mice from the tail once a week into Monovette 200 Z-Gel (Sarstedt, Cat Nr.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serum", "was", "collected", ...

PMC11585565

Individual data points are shown with means and standard errors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Individual", "data", "points", "are", "shown", "with", "means", "and", "standard", "errors", ...

PMC11461833

The LaminA/C expression level was measured by western blotting with an anti-Lamin A/C antibody, and a graph was generated. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LaminA/C", ...

PMC11402217

= 471.18 g/mol, cLogP = 3.47, Figure 1A) emerging as the most effective against OS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "=", "471.18", "g/mol", ",", "cLogP", ...

PMC11767725

These cytokines create an inflammatory milieu that disrupts microbial homeostasis, favoring pathogenic taxa like Staphylococcus aureus and Streptococcus pyogenes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cytokines", "create...

PMC9621239

Additionally, 5 of 24 patients with HCC in this study were found to be co-infected with HBV of multiple genotypes based on the HBV X gene (Figure 1G-K), which made it possible to investigate the distribution trend of different HBV genotypes in the liver tissues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11676169

Interestingly, BCAT1-depleted cells showed pronounced sensitivity to DNA-damaging agents such as etoposide; however, how BCAT1 regulates this sensitivity remains uncertain.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interes...

PMC11638255

Moreover, we have confirmed that TETA is a highly effective, non-toxic, and specific copper chelating agent.

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PMC11419566

PA inhibited CYP2C9 activity in rat liver microsomes in this experiment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PA", "inhibited", "CYP2C9", "activity", "in", "rat", "liver", "microsomes", "in", "th...

PMC10965680

Among the immune response-related genes screened, DOCK8 was investigated for its ability to confer immunity as a positively selected gene in Yunling goats (Kim et al., 2016).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10976516

Increased and broadening tropism for various cell types will, however, bear invariable risk of accumulation in non-tumor-bearing tissue so extra care should be given to the use of attenuated OVs with strictly limited pathogenicity to normal tissues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

DIC was present in 2 patients (20%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DIC", "was", "present", "in", "2", "patients", "(", "20", "%", ")", "." ] } ]

PMC11766332

In the end, study miRNAs were selected according with the following inclusion criteria: miRNAs (1) reported to be deregulated in at least two independent studies (ASD-miRNAs) and (2) identified in a cellular context (i.e., lymphoblastoid cell line, frontal cortex, cerebellar cortex).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Further research studies are needed to improve screening, diagnosis, and management of IDA in this patient population.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "research", "studies", ...

PMC11742290

These findings suggest that LGR5 expression may modulate the Wnt/β-catenin pathway to varying extents based on hormone receptor status.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "t...

PMC11352746

In a Google Scholar search of twelve live-cell imaging devices and the publications that utilize them in neuroscience, it was discovered that Leica microscopes were the most frequently used imaging devices among the twelve.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

TDT patients suffer from chronic anaemia and the effects of iron overload despite chelation therapy, both of which result in significant morbidity and lead to premature mortality.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11770130

The demographic traits of participants were collected and the habitual dietary information was collected using a validated food frequency questionnaire.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "demographic", "traits...

PMC11790599

This study reveals a novel link between NRF2 activation and catastrophic macropinocytosis in breast cancer cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "reveals", "a", "novel", "l...

PMC11507371

Even though the outcomes of initial clinical trials targeting head and neck SCC show signs of the effectiveness and safety of CAP , the untapped potential that a deep comprehension of the definite CAP-triggered intracellular mechanisms harbours should not be underestimated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

There is no study comparing different DOAC for CVT treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "no", "study", "comparing", "different", "DOAC", "for", "CVT", "treatment", ...

PMC11612794

The predicted structure of chicken Mis12C comprised two head domains (Head1: composed of Mis12 and Pmf1; and Head2: composed of Dsn1 and Nsl1) connected to a coiled-coil stalk domain, which is composed of Mis12, Pmf1, Dsn1, and Nsl1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7342409

Effect of imatinib on drug sensitivity of GIST882 cell line. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "imatinib", "on", "drug", "sensitivity", "of", "GIST882", "cell", ...

PMC10761218

A viscous semisolid mass was produced using a rotary evaporator to concentrate the extract under reduced pressure at 40°C.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "viscous", "s...

PMC7887261

The sporadic LC patients were selected from our previous WES study, including samples from the HSPH, Baylor College of Medicine (BCM), and MD Anderson Cancer Center (MDACC).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8728081

The surface elemental analysis was conducted by X-ray Photoelectron Spectroscopy (XPS, Kratos Analytical, Japan) equipped with a monochromatic X-ray source of 1486.6 eV. The peak position (binding energies) was calibrated with a standard gold peak (Au 4f7/2) at a position of 83.95 eV. The XPS peaks were analyzed and de...

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PMC11739504

PTMs affect microtubule dynamics, organization, and interactions with other cellular components and process occurs in tubulin dimers, including α-tubulin and β-tubulin.

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PMC11064533

The Datsenko-Wanner recombineering method was applied with minor modifications for gene deletion of flgH and spy genes (32).

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PMC11706776

Cells were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM, Lonza, Basel, Switzerland) or in Rosewell Park Memorial Institute Medium (Lonza), supplemented with 10% Fetal Bovin Serum (FBS, Lonza).

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PMC11429241

The scaffold architecture type showed differences for the A2780 cell line—spheroid scaffolds were a hit for forming 3D cultures.

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PMC11791478

C, Late-intervention model with a single dose of XB002.

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PMC11740508

S1200, SelleckChem®) or carrier given by intraperitoneal (IP) injection.

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PMC11541409

GOF mutations in PDGFRA, while less frequent (about 5%) than KIT mutations, have a similar mutation pattern like KIT mutants in GISTs.

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PMC11474209

Humans can be exposed to MC-LR from recreational activities, drinking water, fish, shellfish, vegetables, and dietary supplements made from algae .

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PMC8270637

Forward: 5’- CCTCACATCTCTGAGACCCG -3’ Reverse: 5’- CCGAAGCGAGGCTAGAAACC -3’ (PD-1 promoter); Forward: 5’- GAGGACCCTTGTACTCCAGGAA -3’ Reverse: 5’- CGAAAAGACAACCTCAAGCACTC -3’ (CTLA-4 promoter).

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PMC10667689

Currently, there are a few studies about the possible role of TIM-3 in metabolic reprogramming.

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PMC11291490

n = 3).

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PMC11317131

By targeting att sites to the genome using technologies such as prime editing, integrases can target safe loci while avoiding double-strand breaks.

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PMC11533140

Thus, compound 17p had favorable pharmacokinetic properties.

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PMC11387401

Thicker connectors correspond to interactions with higher interaction scores.

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PMC9352806

For thrashing frequency of the head, the head of worms from one side to the other and then back within 1 min on clean NGM was recorded under a stereo microscope.

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PMC11599565

Both GSIs increased ChgA expression, and this effect was slightly potentiated in the presence of the MAP4K4 inhibitor (K-L).

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PMC11682172

More than 30% of patients suffering from common cancers will develop brain metastatic disease and incidences are rising.

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PMC11409031

After that, cDNA synthesis was performed with HiScript II SuperMix (Vazyme, China) using 500 ng of RNA.

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PMC11461833

Co-IP was performed as previously reported .

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PMC11678130

Moreover, melanomas shelter important alterations in functional genes.

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PMC11670954

Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on day 22. (

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PMC10955424

This study is a follow-up to our earlier research that showed how a TME component promotes OC chemoresistance .

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PMC11659734

However, the lack of a significant increase in the Lys signal indicated that, despite the presence of oxidative damage, direct DNA strand breaks could not be as pronounced at the tested concentrations.

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PMC11634027

Transfected cells were lysed in RIPA buffer (140 mM NaCl, 10 mM Tris-HCl pH 8.0, 1 mM EDTA pH 8.0, 1.0% Triton X-100, 0.1% SDS, and 0.1% sodium deoxycholate) supplemented with Protease Inhibitor Cocktail COMPLETE EDTA-Free (Roche, 11873580001) and Phosphatase Inhibitor Cocktail Set II (Millipore, 524625) for 30 min at ...

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PMC9429973

Results: 12 out of 67 children (17.9%) had allergy in our cohort, representing 16 episodes of varying severity (Figure 1A).

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PMC11640419

Oleanolic acid (OA) is one of the most prevalent pentacyclic triterpenoids in nature.

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PMC11635087

Considering future applications, we speculated that chloroplasts incorporated into animal cells may remain stable and continuously produce energy regardless of environmental conditions.

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PMC10490530

pcDNA3.1-CMV-hLuz plasmid was synthesized using GeneArt (ThermoFisher) service.

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PMC9429973

Acalabrutinib is a highly selective, potent, covalent BTK inhibitor that demonstrated less toxicity and improved tolerability in a head-to-head trial versus ibrutinib in chronic lymphocytic leukemia.

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PMC11402217

Protein expression levels of DKK1 and β-catenin were evaluated by probing with corresponding antibodies on the sections.

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PMC11082662

In this study, we aimed to identify target genes that are markedly upregulated in ovarian cancer and associated with poor prognosis through bioinformatics analysis.

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PMC7917457

Oncolytic potency of VALO-D102 is identical to the parental strain and is not affected by coating the virus with tumor antigens (A–E) Oncolytic potency of VALO-D102 and PeptiCRAd-1, a cancer vaccine platform consisting of VALO-D102 coated with two modified tumor antigens, was compared to the Ad5/3-D24 parental strain i...

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PMC11741577

Wound closure was measured, and tissue regeneration was assessed using hematoxylin and eosin staining.

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PMC11534035

Colony size is reduced after SERPINE1/PAI1 knockdown in VSCC.

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PMC10761571

Also, the CASP8 and BAX genes were upregulated by 2.49 and 2.8 folds, respectively, while a downregulation by 0.75 folds was noticed for the BCL2.

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PMC11228511

In Lmnb1 cells with a nuclear bleb (n = 156), 90.2% had an abnormal lamin A meshwork; in cells without a nuclear bleb (n = 129), 43.9% had an abnormal lamin A meshwork (Fig. 7D).

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PMC4816271

Phusion polymerase, quick Ligase and NEB5alpha (New England Biolabs, New England) were used for molecular cloning.

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PMC9429973

Rather, DR to ≤95% of actual weight-based dose, has been shown to result in shortened overall survival (OS).

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PMC9429973

Results: EZH2 mRNA level was significantly increased in 53 newly diagnosed patients with AML compared to 20 healthy bone marrow control(p<0.0001)(Fig.1A).

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PMC11060216

Both TTF-1 and NapsinA were expressed and the total score in all 15 samples were more than 4 (P>0.05).

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PMC10975211

The authors synthesized the D-stereoisomeric form of buforin IIb that was reacted with a malonate-type linker to obtain an O,O’-bidentate linker that was further complexed with cis-[Pt(NH3)2(H2O)2] to produce cis-[Pt(NH3)2(malBuf–2H)].

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PMC11291490

According to those, dusCD40L was incorporated into the TMUV prM-E DNA vaccine with P2A.

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PMC11747949

After 48‐h incubation in 1% or 21% O2, supernatants were collected from the top or bottom chambers, centrifuged 300 × g for 5 min.

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PMC9429973

Substrates of OMA1 include the mitochondrial GTPase OPA1 and DELE1, a mitochondrial protein recently shown to act as a sensor of mitochondrial dysfunction and to signal through HRI kinase and ATF4.

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PMC9596868

Quercetin treated cells displayed 100-fold reduction in telomerase activity when compared to vehicle control while cells treated with combination of MST-312 and quercetin displayed 1000-fold reduction in telomerase activity when compared to the vehicle control (Fig. 5E).

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PMC11180402

It has been reported that miR-129 is downregulated in breast cancer , colorectal cancer , gastric cancer , and pancreatic cancer .

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PMC8526701

Tumor volume at indicated time points after treatment was calculated and plotted with p values for indicated comparisons, n = 6 in each group.

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PMC9429973

Summary/Conclusion: Treatment with RUX and POM was safe and feasible in our study of advanced MF with an adverse genetic profile.

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PMC8427838

This assay also showed that moesin binds to TMIGD1 (Fig. 1D).

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PMC9143157

The patient has recorded no evidence of disease relapse for eight years .

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PMC8382973

In rabbits treated with 100 mg/day SDS, epithelial disruption and vascular congestion were observed.

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PMC11704135

These properties highlight their potential as targeted therapies against various types of cancers, although further research and clinical trials are necessary to fully explore their efficacy and optimize their therapeutic potential.

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PMC11638255

Although myeloid cells have been historically associated with an immunosuppressive phenotype in neuroblastoma, recent investigations into subset diversity have revealed a heterogeneous range of microenvironment-dependent populations (reviewed in ref. ).

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PMC9429973

A meta-analysis concluded that APLA were detected in nearly half of hospitalized patients with COVID-19, and even higher prevalence was found in patients with severe disease.

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PMC11742290

In early-stage cancer, TGFβ inhibits cell proliferation, induces apoptosis, and maintains tissue homeostasis by promoting differentiation and reducing inflammation .

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PMC10577955

Thin-layer chromatography (TLC) was performed on silica gel GF254 precoated plates (Fluka, Steinheim, Germany) using the following solvent systems: n-Hexane: ethyl acetate (8:2 and 7:3 v/v).

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PMC11739504

To evaluate the role in ciliogenesis in vitro, Kat2b-depleted NIH/3T3 cells were generated using short hairpin RNA (shRNA) against Kat2b.

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PMC10968586

A similar growth inhibition was also obtained for MCF-7 cells .

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PMC6803987

The plates were read directly at 450 nm with a microplate reader.

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PMC11541241

In addition, we present disease control strategies using this pathway.

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PMC11286266

Disruption of endogenous cgATF6α in XC45-6S cells by CRISPR/Cas9 genome editing abolished the responsiveness of the BiP::sfGFP reporter to ER stress and derepressed IRE1 signalling, both basally and in response to ER stress.

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PMC9429973

Vaccination using two subtypes of mRNA-based vaccines, BNT162b2 or mRNA-1273, is an effective public health measure to reduce the risk of infection and severe complications from COVID-19.

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PMC9776316

Moreover, the specific mutation of binding site 2 abrogated the increased XRCC4 luciferase activity by the cJUN overexpression in both the A2780cisR and SKOV3cisR cell lines, suggesting that cJUN specifically binds to the S2 site (−698~−692) in the XRCC4 promoter sequence to drive its transcription.

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PMC11388384

All experiments in which conditioned medium was used included an equal fraction of conditioned media, mixing SCUBE1-containing conditioned media with wild-type conditioned media to achieve the stated SCUBE1 conditioned media fraction.

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PMC10547921

Enediyne can be divided into two subfamilies: Cal-like enediyne and anthraquinone fusion enediyne.

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PMC11092418

Data analysis was performed using Calcusyn software (Biosoft, UK) and interpreted as follow: < 0.9 = synergistic effect, 0.9 - 1.1 = additive effect, > 1.1 = antagonistic effect.

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PMC10024132

γ9δ2 T cells were expanded from PBMCs for 17 days and then isolated for adoptive transfer. (

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PMC10218459

The IC50 of the cytostatics was reduced depending on the duration of CPP treatment.

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PMC11377827

We validated the findings of the HIF activator screen in two non-cancer cell lines, HKC-8 (renal tubular epithelial cells) and RPE-1 (retinal pigment epithelial cells), where HIF responses have been well-validated (Cristante et al, 2023; Smythies et al, 2019).

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PMC9268183

One of them is Silybum marianum, a very well-studied plant , which is indeed a great example to illustrate the importance of common plants for cancer research in particular, and for medicine in general.

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PMC11721277

To assess tumor uptake and study the effect of dose on the biodistribution, mice bearing A-431 xenografts were injected intravenously into the tail vein with 1.2 mg/kg (30 µg/mouse, 60 kBq), 6 mg/kg (150 µg/mouse, 60 kBq), and 12 mg/kg (300 µg/mouse, 60 kBq) of [Tc]Tc-HYNIC-Chl.

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PMC11525028

This study uncovered the essential roles of NAT10 and ac4C modification in osteosarcoma and identified NAT10 inhibitors through virtual screening.

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PMC11762280

ns not significant.

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PMC10812665

This “reductive stress” (= increased NADH/NAD ratio) leads to a reversal of several metabolite balances.

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