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OTAR3088
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PMC4005030
Protocatechuic acid has shown promising anti-inflammatory and analgesic activity in different rat models (carrageenan-induced paw oedema, cotton pellet-induced granuloma, and Freund's adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain.
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PMC11394112
However, without engraftment success rates in MISTRG or MISTRG6, we could not explain such a difference.
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PMC9429973
DNA was purified using a Maxwell RSC Blood DNA Kit (Promega), RNA was isolated using TRIzol reagent (Invitrogen) and cDNA synthesis was performed using the First Strand cDNA Synthesis kit (Roche).
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PMC8316344
Vast majority of studies have also suggested that TRIB2 can interact with a serial of E3s, such as βTrCP , SMAD specific E3 ubiquitin protein ligase 1 (Smurf1, ) and COP1 E3 ubiquitin ligase (COP1, ) at its C terminus.
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PMC11659921
Previous research has demonstrated that cancer stem cells promote tumor angiogenesis, while increased vascularity, in turn, fosters the growth of cancer stem cells.
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PMC11546117
Ethical approval for acquiring, passaging, storing, and culturing hMECs was obtained from the Ethics Committee Research (EC Research) UZ/KU, Leuven, Belgium (reference number S67546).
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PMC9777812
The results reported represent the mean of three independent experiments.
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PMC11001582
in 4 min; the final minute of the test was performed at 40 r.p.m.
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PMC7153288
Among 20 predicted gene clusters of Streptomyces sp. SS1-1, five gene clusters had 100% similarity with known gene clusters in Streptomyces species.
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PMC9429973
In patients achieving CR either three consolidation cycles with high/intermediate doses of cytarabine or allogenic SCT in selected patients were performed.
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PMC11348300
PpIX was induced through topical application of ALA on the right leg of a nude mouse, while PdG4 was injected directly subcutaneously in the opposite leg.
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PMC11190538
Fig. 8Sensory evaluation of yogurt during 21 days of storage at 5°CN·B: All yogurt variants were fermented with L. rhamnosus KU985435, C: control without C-PC, T1: treatment with 150 mg free C-PC, T2: treatment with 300 mg free C-PC, T3: treatment with 150 mg C-PC nanophytosomes (at molar ratio 1:2), T4: treatment with...
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PMC11247842
The model for estimation of breeding values was a multi-trait random regression test-day animal model.
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PMC9429973
S. Maria, Terni; Hematology, Azienda Sanitaria Universitaria Friuli Centrale, Udine; Oncology and Hematology, IRCCS Centro di Riferimento Oncologico, Aviano; Hematology, ASST Spedali Civili, Brescia; Hematology and Department of Translational Medicine, Università del Piemonte Orientale e AOU Maggiore della Carità, Nova...
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PMC9966931
Prior to the experiments, the microorganisms were activated at 28 °C on potato dextrose agar (PDA) medium for 7 days.
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PMC11411131
For instance, Minamata disease, a MeHg intoxication-induced neurological disorder found in Japan, shows two characteristic clinical forms (fetal type and adult type), depending on the exposure age.
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PMC11055323
Cells were resuspended in 50 μl of 0.5%SDS and incubated for 8 min at 62 °C.
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PMC7504302
The EMT process plays an essential role in MPM pathogenesis and is associated with high-grade malignancy, thus poor prognosis.
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PMC7039683
The Picard toolset (http://broadinstitute.github.io/picard/) was used to check fragment size distribution.
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PMC11297139
Our results indicate that EWS/FLI1-bound cREs, dysregulated in cells with ARID1A LLPS, induce expression of oncogenic genes that increase the oncogenic potential of A673 cells.
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PMC2196094
A number of clones from each of the above described screenings and cloning of the various proteases have been analyzed and all clones were found to contain the 3′ end of the mRNAs.
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PMC11409031
Apoptosis is a programmed cell death mechanism aimed at maintaining cellular balance and clearing abnormal cells in the body .
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PMC11271278
DNA FISH on metaphase spreads showed the presence of ecDNAs containing both MYC and ERBB2 across examined cells (Fig. 6A).
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PMC11413393
Using the rMATS ‘junction counts”/”exon counts” (JCEC) counting methodology, a total of 2442 significant (FDR ≤ 0.01) ASEs with a delta percent spliced in (PSI) of ≤−0.1 were detected and a total of 2575 significant (FDR ≤ 0.01) ASEs with a delta PSI of ≥ 0.1 were detected after MS023 treatment (Fig. 7d).
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PMC11656048
Excessive Fe in cells can produce a large number of ROS via the Fenton reaction.
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PMC9429973
Results: Overall, 281 patients (intent-to-treat population; 150, 85, 31 and 15 patients in mainland China, Japan, South Korea and Taiwan, respectively) were analyzed (141 received Pola-R-CHP and 140 received R-CHOP); 160 patients from the global population and 121 from the China extension cohort.
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PMC10452486
that are found in all classical HLA class I isomers are also found in the β-chain of DRB, DQB, and DPB isomers of HLA class II, as illustrated in Table 6.
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PMC7192625
The first feature that we examined was tri-methylation of Lysine 27 on histone 3 (H3K27me3), a chromatin mark which is strongly associated with Polycomb repressed chromatin (44) that was found to be assortative in mESCs (25).
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PMC11672142
1 μL of matrix was placed on the MALDI wells and allowed to crystallize.
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PMC7841067
Total RNA was isolated from thyroid cancer cells using TRIzol reagent (Invitrogen) according to the manufacturer’s instructions.
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PMC10877303
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC9429973
In vivo activity of WU-NK-101 was confirmed in an AML THP-1 xenograft model, where a single dose effectively reduced tumor burden relative to vehicle controls.
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PMC11696576
In this study, we report the synthesis and characterization of a series of thiazolyl ketone inhibitors targeting cPLA2α, using GK470 (AVX235) as the starting compound.
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PMC11732628
Our data found that the decreased expression of CDCA8 and ATF3 in the miR-490-3p-overexpressed 143B cells was increased by NUSAP1 overexpression, which suggests that miR-490-3p mediates CDCA8/ATF3 by targeting NUSAP1.
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PMC9812014
Tubingensin A—an alkaloid isolated from Aspergillus tubingensis (R.Mosseray 1934)—was also reported to have activity against HSV-I in an in vitro experiment, with an IC50 of 8 µg/mL .
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PMC4485786
However, mice treated with IL-12 and IL-7 constructs did not show an increase in cells expressing granzyme or perforin.
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PMC8481254
Kinases are involved in the process of O-GlcNAcylation and play an important role .
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PMC7057940
The presence of small round cells with narrow cytoplasm and oval hyperchromatic and granulated nuclei constitutes another key feature of ES tissue (8).
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PMC10933092
Among the miRNAs predicted to bind to ENST000536140 and SCN2B, two miRNAs, hsa-miR-6134 and hsa-miR-7854-3p, bind to both transcripts.
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PMC11641532
Although we utilized both publicly available datasets and experimental validation to identify and characterize HSD3B7, further investigations are needed to fully elucidate the molecular mechanisms underlying its oncogenic activity in ccRCC.
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PMC10482220
Proteins were analyzed by Western blotting using dilutions of primary antibodies as follows: 1/3,000 for anti-G3BP (200 ng/ml), 1/3,000 for anti-HuR (3A2), 1/1,000 for anti-Ran (Santa Cruz Biotechnology, Inc.), 1/1,000 for anti-eIf2α (Santa Cruz Biotechnology, Inc.), 1/200 for anti-Rac, and 1/200 for anti-RhoA. Anti-Hu...
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PMC11792090
The SAP module consists of the CD47 extracellular domain, a mutant interleukin 7 receptor alpha (IL7Rα) transmembrane domain, and the IL7Rα intracellular domain, designed to protect UCAR-T cells from host immune attacks and enhance their survival.
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PMC7685376
For WB, the detailed procedures were performed as described previously using the following primary antibodies: anti-MCM2 (Abcam, ab4461), anti-MCM3 (Abcam, ab128923), anti-MCM4 (Abcam, ab4459), anti-MCM5 (Abcam, ab75975), anti-MCM6 (Abcam, ab201683), anti-MCM7 (Abcam, ab2360), anti-CDK9 (Abcam, ab76320), anti-CyclinD1 ...
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PMC9031474
In vivo studies are only available for antidiabetic and antimalarial activities of some drimane sesquiterpenoids and plant extracts .
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PMC8753818
As in G0/G1 phase cells represent higher metabolic activity, inducing growth arrest at this phase is a known strategy for enhancing productivity of mammalian cell lines [35–37].
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PMC10976516
Jiang et al.ICOVIR-15 with E2F responsive palindromes in E1A promoter, as CRAd derived from AdΔ24-RGD; replication-incompetent Ad-iC9, expressing inducible caspase-9IntravenousBone marrow-derived MSCs loaded with combined ICOVIR-15 and Ad-iC9MSC loaded with ICOVIR-15/Ad-iC9 were systemically applied in a subcutaneous A...
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PMC11533140
In this work, we studied series A derivatives formed by substituting position 2, 4, or 6 (Figure 3), but their inhibitory activities were unsatisfactory; thereafter, the pyrimidine-5-carbonitrile fragment, widely used for discovering anti-cancer, anti-inflammatory, and COX-2 candidates (Abdel-Aziz et al., 2021; Nasser ...
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PMC11093197
TaqMan probes and primers used were as follows: CDH1 (Hs01023894_m1), TWIST1 (Hs01675818_s1), SNAI1 (Hs00195591_m1), ZEB1 (Hs00232783_m1), MYC (forward: AATGAAAAGGCCCCCAAGGTAGTTATCC, reverse: GTCGTTTCCGCAACAAGTCCTCTTC).
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PMC7334607
Estimated EC50 for each replicate is denoted with a red circle.
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PMC6892818
Interestingly, the induction of p-p38 lagged behind the activation of p-JNK, as JNK phosphorylation plateaued by 1.5 h whereas maximal p-p38 expression was evident at later time-points (3 h in A-704 or 6 h in ACHN cells) (Fig. 6a).
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PMC11422150
As for the sensory function, it was evaluated using the paw withdrawal reflex.
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PMC11742670
Besides, the IC50 on OEC and HSF were 9.47 and 18.31 µg/mL, respectively.
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PMC11803149
The tumor size on the day of adoptive transfer was below 2.5-5.0 mm in both length and width.
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PMC11678448
This study provides deeper insights into the immune responses induced by P. multocida in the PBLs of goats, which will facilitate the development of specific diagnostic markers and vaccine adjuvants aimed at immune activation.
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PMC10758402
For human tissue samples, tumor samples were collected from patients who had given informed consent and followed the Declaration of Helsinki guidelines during surgical resection.
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PMC4816271
The four hinge regions were compared in terms of cytotoxicity (c) (Lan1 = GD2 positive target and A204 = GD2 negative target), IFN-γ secretion (d), IL-2 (e) and target-specific proliferation (f).
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PMC11632064
Next, the proliferative effect of knockout and gene silencing of the same kinases on melanoma cell lines was examined using the DepMap portal.
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PMC9429973
Methods: Adjusted comparisons were estimated using individual patient data (IPD) from CARTITUDE-1 (cut-off date July 2021) and reconstructed IPD from EMMY (cut-off date March 2021).
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PMC9895440
Full blot scans are found in the source data file for the linked figures.
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PMC11413393
To assess ICL repair, we performed immunofluorescent staining for FANCD2 foci, a hallmark of a functional FA pathway.
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PMC10094712
The first group includes selenoproteins characterized by the presence of selenocysteine in the C-terminal sequence of these proteins.
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PMC10587429
Micro cover glasses (48404-453, VWR, Radnor, PA). -
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PMC11519567
This alteration of SS18-SSX1 condensates is dependent on H2AK119ub recognition by C-SSX.
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PMC11478724
To evaluate the two-dimensional cell migration, the Scratch assay was conducted as follows: 2 × 10 A549 cells were seeded in a 6-well plate and cultured under optimal cell growth conditions for 24 h. Next, a scratch line was made in the middle of the well using the tip of the yellow sampler.
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PMC11413393
Western blots were carried out as described above.
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PMC11696576
An example of the gating strategy to assess PI staining can be found in Fig. S8c.
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PMC9221284
Of course, these transcripts will differ depending on the type of B lymphoma that is associated with specific c-MYC dysregulation.
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PMC11297139
Statistics by two-tailed t-test using ARID1A + WT, and ARID1A + ΔDD A673 cell lines as comparison.
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PMC11701801
The sensitivity of SMARCA4-deficient cancer cell lines to CBP/p300 dual inhibitors was similar to that of SWI/SNF WT cell lines.
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PMC11770199
Cells were fixed with 4% paraformaldehyde and imaged with a fluorescence microscope (Olympus, Japan) using 10× objective.
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PMC5308810
When tumor reached approximately 100 mm (approximately 14 days following inoculation), mice were randomized into two groups (n = 4/group) for treatment with doxorubicin (5 mg/kg) in PBS (200 μL) or vehicle only via tail vein injections.
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PMC11087055
To address the relationship between the polonaise movements and the population of the PS cells, we live-imaged the fluorescently tagged embryos under aphidicolin-treatment and analyzed the resulting cell flow (Figure 2F–K”’ and Video 2).
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PMC9895440
n = 10 donors from n = 5 experiments except for Teff n = 4 of n = 2 experiments.
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PMC6114978
These mechanisms include: regulation by ubiquitin-mediated degradation, as well as two distinct methods of epigenetic regulation, promoter hypermethylation and histone deacetylation (Figure 7B).
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PMC11473750
p < 0.05.
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PMC11727062
This reduction in PFKFB4 expression decreases the production of lactate and fructose-1,6-bisphosphate, which are often overproduced in melanoma cells.
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PMC11696576
To a stirred solution of phenols 10a–e or 10k (1.00 mmol) in acetone (10 mL), K2CO3 (3.00 mmol, 415 mg) and ethyl bromoacetate or ethyl 2-bromopropionate or hexyl bromide (1.10 mmol) was added, and the reaction mixture was refluxed for 5 h. Then, the mixture was filtrated over Celite, and the organic solvent was evapor...
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PMC11537649
Next, we investigated whether Lnc NEAT1 affected the invasion and migration ability of melanoma cells.
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PMC9046263
We also collected M (log2 fold ratio of methylated probes to unmethylated probes) and beta-values (percentage of methylated probes) before generating a model to assess methylation pattern by cell line.
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PMC11790971
Label-free multimodal nonlinear optical microscopy demonstrated remarkable capabilities in differentiating CHO cell lines with varying production phenotypes in early passages, as substantiated by the cross-validated classification results presented in Fig. 2.
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PMC11765243
with 100 µg of keyhole limpet hemocyanin (KLH, Sigma-Aldrich-Merck; Ref.
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PMC9792775
Low-frequency ultrasound (LFU), a non-invasive procedure that has been documented to increase the efficiency of drug passage into cells by inducing reversible changes in membrane permeability, could allow local treatment of tumors and reduce side effects of drug treatment (Shen et al., 2014; Schoellhammer and Traverso,...
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PMC11488203
Among further signaling molecules exosomes also contain a variety of different RNAs such as mRNAs, long non-coding RNAs, and regulatory microRNAs (miRs), which can alter the functionality of recipient cells .
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PMC11487720
Together, in response to UV/cold shock, WWOX binds and carries TRAF2 to relocate to the nucleus, followed by dissociation at 4°C.
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PMC11434983
After thorough shaking to solubilize the formed MTT crystals, the absorbance of each well was measured in an ELISA reader at the test and reference wavelengths of 540 and 620 nm, respectively.
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PMC9429973
Summary/Conclusion: Combining these observations, we were able to identify vulnerabilities to glutamine metabolism in MYC overexpressing cells.
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PMC9429973
There was no difference in 1-year OS rate between the two groups.
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PMC11290772
Surprisingly, the ROBO1-NK cells exhibited a substantially accelerated rate of lysing the ovarian cancer organoids compared with primary cancer cells in this investigation, achieving lysis within a mere 12 h (Figure 4A) in contrast to the 48 h needed for primary cancer cell lysis (Figure 3E).
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PMC11806818
Photoelectrochemical (PEC) sensing uses light as the excitation source and the generated photocurrent as the detection signal.
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PMC7081114
As shown in Figure 2A, at 72 h after transfection, the proportion of infected cells in both the shCtrl and shKIF21B groups had reached 80%.
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PMC11521786
All samples were evaluated in triplicate.
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PMC11001582
On completion of these procedures, a subcutaneous injection of buprenorphine (0.1 mg kg) was administered for immediate postsurgical pain relief.
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PMC11787355
After a quick wash with PBS, they were then pre-treated with RNAscope Protease IV.
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PMC9429973
After the first procedure, complete venous patency was achieved in 3 patients (15%), 11 patients (55%) almost complete, partial recanalization in 4 patients (20%) and failure in recanalization in 2 patients(10%).After 24 hours of thrombolytic infusion with alteplase or urokinase: 11patients required additional angiopla...
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PMC11509309
Then, 10 µL of WST-8 was added to each well and OD450 was measured after 4 h incubation at 37 °C with 5% CO2 using a Varioskan plate reader (Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11643491
Experiments were performed using A375 primary human melanoma cells from ATCC (American Type Culture Collection, Manassas, VA, USA), and were mycoplasma-free.
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PMC9429973
Unbiased co-segregation analysis revealed 15 positive and 3 negative correlations between the various CNAs, e.g. common co-occurrence of iAMP21 and CDKN2A/B deletion, and negative correlation between ETV6 and BTG1 deletions.
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PMC9429973
Therefore, we designed the HOVON-152 trial to investigate whether survival can be improved by nivolumab consolidation after DA-EPOCH-R induction.
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PMC11335267
The expression of the proinflammatory genes Il-12b, TNFα and TGFβ was similarly increased in the vWAT of Alx3-deficient and control animals fed with HFD (Fig. 2K).
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PMC5673060
All ratios were median-normalised and log2 transformed.
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