OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9143157	Platinum-containing regimens were commonly used with paclitaxel plus carboplatin (TC) for first-line ovarian cancer treatment, and pegylated liposomal doxorubicin (Doxil) plus carboplatin (PLD-C) is also used for recurrence .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11545868	Recently, Pessoa, J. et al. investigated how cytochrome c can be applied to the development of various anticancer therapies to optimize their apoptotic efficacy and stabilize them for targeted delivery to cancer cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329074	First, YBX3 was found to be significantly expressed in the various types of cancer tissues analyzed, namely cholangiocarcinoma (CHOL) (P < 0.001), colon adenocarcinoma (COAD) (P < 0.05), esophageal carcinoma (ESCA) (P < 0.001), ccRCC (P < 0.001), renal papillary cell carcinoma (KIRP) (P < 0.001), lung squamous cell car...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	To remove variable P(t), we introduce a new variable s(t), which is a binary variable that indicates the buying/selling status of the community from/to the EP at each time slot t.25[12pt] $$ s(t) = 1 & _^E_^(t) > _^E_^(t) \\ 0 & _^E_^(t) < _^E_^(t) . }	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	The cells were then screened in DMEM medium supplemented with G418 (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "screened", "in", "DMEM", "medium", "s...
PMC11204465	One new compound, dihydrodemethylsterigmatocystin (69), was isolated from Aspergillus versicolor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "new", "compound", ",", "dihydrodemethylsterigmatocystin", "(", ...
PMC7305184	The results are shown as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "shown", "as", "mean", "±", "SD", "." ] } ]
PMC9429973	Image: Summary/Conclusion: We demonstrate: (i) that switching of TKI is frequent and mainly driven by intolerance in all lines of treatment; (ii) serial intolerance is 6.6 time more frequent than serial resistance suggesting a class effect for intolerance in some patients; (iii) all TKIs have a similar «retention level...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669966	Data from the newest version of in silico transcriptomic (IST; ) database (MediSapiens Ltd., Helsinki, Finland) were fetched into R by using Dplyr extension for SQlite.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Expression of polyGR in human iPS cell neurons was sufficient to induce TGFB1 expression followed by COL6A1, and knockdown of the COL6A1 or TGFB1 homologs in flies expressing 36 GR repeats showed a specific and striking enhancement of neurodegeneration, pointing to a neuroprotective effect of collagen induction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Disease phase at transplant is an important risk factor for alloHCT outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disease", "phase", "at", "transplant", "is", "an", "important", "risk", "factor"...
PMC11216402	Across cell lines, the expression of COL1A1 is highly correlated with the activity of the peaks COL1A1_E1 and COL1A1_E2 (r = 0.64 and 0.58) (Supplemental Figs. S21, S22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Of note, the downregulation of E-Cadherin, the upregulation of N-Cadherin along with several associated proteins, appear to play paramount roles in epithelial—mesenchymal transition (EMT) making it a potentially targetable process in the treatment of OCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	The cell lysate served as a source of Gαi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lysate", "served", "as", "a", "source", "of", "Gαi", "." ] } ]
PMC11756514	Only a few papers have examined the interaction of SP-D with S. aureus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "a", "few", "papers", "have", "examined", "the", "interaction", ...
PMC11782508	The presence of azurin in the cell extract was confirmed using the CuCl₂ method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "azurin", "in", "the", "cell", "extract"...
PMC8567602	F, Heat maps of ChIP-seq distributions around TSSs across the whole genome, ordered by enrichment for SMARCA4 in hSS2-only tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", ",", ...
PMC11767582	The organic phase was dried over anhydrous Na2SO4 and the mixture was concentrated to dryness and purified by flash column chromatography on silica gel using mixtures of n-hexane and ethyl acetate as eluents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711347	According to a previous study by Eka Pratiwi et al. that examined Ni(II) complex activity on breast cancer cells, the Ni(II)cysteine-tyrosinedithiocarbamate complex exhibited lower cytotoxicity compared to cisplatin, as indicated by the IC50 values of the two compounds .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11441402	Quantifying drug cytotoxicity is a critical tool for broadening our understanding of cell biology and identifying new therapeutic compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantifying", "drug", "cytotoxicity", ...
PMC11286266	Selected pathways are ranked by p-value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selected", "pathways", "are", "ranked", "by", "p-value", "." ] } ]
PMC10999934	A gene at log2FC greater than 0.5 and an adjusted P value less than 0.05 was considered a DEG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "gene", "at", "log2FC", ...
PMC9429973	The overall 60-day mortality was 25.8%, with no death related to thrombosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "overall", "60-day", "mortality", "was", "25.8", "%", ",",...
PMC11515150	Several preclinical studies of antibody-derived CAR-T cell therapies showed that binding membrane-proximal epitope had been revealed to enhance the immune effector function [17–20].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11591038	These earlier findings collectively revealed the link between hypoxia/ischemia and APP expression/processing that may contribute to AD pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "earlier", "findings", "collectively...
PMC11011837	However, differences in the ratios among the cell lines do not reach significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "differences", "in", "the", "ratios", "among", "t...
PMC10656496	Coculture Panobinostat and trametinib treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coculture", "Panobinostat", "and", "trametinib", "treatment", "." ] } ]
PMC4659567	Finally, complex [Ru(η -p-cym)(L9)Cl2] containing mebendazole (L9) showed acute antitumor activity against HeLa cervical cancer cell line with IC50 = 0.20 μM .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", ...
PMC11666785	In addition, we noted that localization precision is not strongly dependent on the degree of correlation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "noted", "that"...
PMC9429973	There are also insufficient data to support the use of thrombolysis in patients with CVT, as only case-reports and patient-series have been published.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Response was assessed every 8 weeks from cycle 3, and every 12 weeks from cycle 13 and was measured according to the iwCLL 2018 criteria, including PR with lymphocytosis (PR-L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	G, H) Bioenergetic analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", ",", "H", ")", "Bioenergetic", "analysis", "." ] } ]
PMC11400680	Figure 3 demonstrates the detailed performance measurements of our prompt generator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3", "demonstrates", "the", "detailed", "performance", "measurements", "of", "our"...
PMC9429973	The mean neutralizing capacity in patients with MM or B-CLL was lower than in controls at all time points after the first vaccine dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11087766	Since PhiPA3 gp108 does not localize to the PhiKZ nucleus (Fig. 1A) but shares high sequence and structural homology to PhiKZ gp104 (Fig. 1G and SI Appendix, Fig. S1A), this approach allowed us to screen for sequence-specific localization effects while still maintaining the full sequence length and general structure of...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	Figure 4Relative distribution patterns of Ki-67, biotin-DHPE, and PS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4Relative", "distribution", "patterns", "of", "Ki-67", ",", "biotin-DHPE", ",", ...
PMC11429241	Despite this, owing to the usage of the material vat with a submerged substrate which was lifted away from the focusing optic after each layer, printing objects with a height higher than the free working distance was made possible.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10858941	In the last years, the key role of the microenvironment in tumour progression has been elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "last", "years", ",", "the", ...
PMC9429973	We recently detected a significant lower expression of NR4A1 that correlates with a poor lymphoma-specific survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "recently", "detected", "a", "significant", "lowe...
PMC11448304	a Quantification overview of identified modification sites and proteins from mass spectrometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Quantification", "overview", "of", "identified", "modification", "sites", "and", ...
PMC11144200	Our observations revealed a significant increase in CD25, CD69, and CD62L expression in LPS-RGD-Nb36-DOX as well as DC/tumor fusion vaccine-activated CD8 T cells (P < 0.001) (Fig. 2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11540664	Patient baseline characteristics, such as age, sex, ECOG Score and AFP, were obtained from their electronic medical records.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient", "b...
PMC11476666	Cells were seeded at a density of 1.2 × 10 cells per well in a 6-well plate, in the following two experimental conditions: pre- or postspheroids formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11437637	Normally distributed data were represented by mean ± standard deviation and differences between groups were analyzed via t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normally", "distributed", "data", "were", ...
PMC11085211	Among them, nine maintained the pharmacological activity in GIST-882 and GIST-T1, suggesting that more than one phytochemical was responsible for the FR2-A effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10698968	To the best of our knowledge, few studies on the role of ribosome biogenesis in sarcomas have been conducted encouraging a deeper investigation of its possible role in myxofibrosarcoma pathogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	7ALOX15B silencing alters membrane lipids.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "7ALOX15B", "silencing", "alters", "membrane", "lipids", "." ] } ]
PMC11794847	This incubation was performed for 30 min under light-protected conditions to ensure the stability and efficacy of the fluorochrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "incubation", "was", "perf...
PMC11787381	The run was performed according to manufacturer’s recommendations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "run", "was", "performed", "according", "to", "manufacturer", "’s", "recommendations", "." ] } ...
PMC9611901	Keratin is the only protein found in hair and the second most abundant protein in leather.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Keratin", "is", "the", "only", "protein", "found", ...
PMC10877303	Several potential vaccines are currently undergoing clinical and preclinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "potential", "vaccines", "are", "currently", "undergoing", "clinical", "and", "preclinical",...
PMC11541409	The NF1 gene encodes neurofibromin 1, which stimulates the GTPase activity of RAS and thus negatively regulates RAS/MAPK signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NF1", "gen...
PMC8345486	Ferra bis(dicarbollide) 2 was taken up by the cells in twice the amount of cobalt bis(dicarbollide) 1 (Figure 4B), but it was considerably less effective on cell viability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	The gene sets for these pathways were obtained from the MsiGDB database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "sets", "for", "these", "pathways", "were", "obtained", "from", ...
PMC10788478	Additionally, mRNA sequencing was performed to compare the expression profiles of cells subjected to different treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "mRNA", "sequencing", "was", ...
PMC11772585	Fig. 2METTL1 knockdown significantly represses cSCC cells survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2METTL1", "knockdown", "significantly", "represses", "cSCC", "cells", "survival", "." ] } ]
PMC9429973	Aims: We recently identified SAMD9/9L mutations in 8% of children with MDS, and a strong association with monosomy 7 (EWOG-MDS; Sahoo et al, Nat Med, 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	For this reason, we decided not to perform any additional biocompatibility evaluation in this work.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "reason", ",", "we", "decided", "n...
PMC11612626	After treatment with compound A, the relative number of the most upregulated peptides that terminated in either Tyr or Phe was consistent with an increase in immunoproteasome-specific activity (Fig. 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9261184	The ship stopped to refuel with diesel in Portland, UK, on 15th April, and the ballast voyage lasted another 13 days to reach Corpus Christi on 28th April.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6948907	Asterisks (*) indicate significant differences between treated cells and the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Asterisks", "(", "*", ")", "indicate", "significant", "differences", ...
PMC11248911	for C13H17N3S (247.36): C, 63.12; H, 6.93; N, 16.99; S, 12.96.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "for", "C13H17N3S", "(", ...
PMC11363012	Therefore, these scMS and scRNA-seq data provide the foundation for the discovery of additional transporters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "these", "scMS", "and", "scRNA-seq", ...
PMC9964635	Hemolytic activity was investigated by the reported method using Triton-X-100 as standard.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hemolytic", "activity", "was", "investigated", "by", "the", "reported", "method", ...
PMC11470999	Quantitative analysis of the protein levels is also shown. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "analysis", "of", "the", "protein", "levels", "is", "also", "shown", ".", "...
PMC9429973	Likewise, both the homozygotes for the minor alleles as well as the heterozygotes (CG/GG for Casp8, AT/TT for Casp10 and AG/GG for FAS) were associated with ALL in children and adolescents (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804	Two PPIs are connected in the network if they share a protein, i.e., each edge in the new graph corresponds to a protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9964654	Aiming to provide water solubility, prolonged availability, and enhanced therapeutic indexes, BCMs loaded with [Au(cdc)2] were synthesized and characterized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8711270	CEVEC pharmaceuticals have developed ELEVECTA® producer cell lines where AAV production genes are stably expressed in CEVEC’s amniocyte production (CAP) cells where gene expression is controlled by an inducible promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10812665	The alterations in amino acid metabolism may not only serve a biomarker function, but they may be directly involved in the cell pathology (in addition to direct effects of c-I inhibitors on mitochondria); (ii) the abundance of NADH might drive some reactions, i.e., shift reaction balances in a way not found in healthy ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	RPMI 1640 (Corning, 10-040-CV) supplemented with 10% fetal bovine serum (Peak Serum, PS-FB2, lot 06C1182) and GlutaMAX (Thermo Fisher Scientific, 35050061) for a final glutamine concentration of 446 mg/L. Eagle's Minimal Essential Medium (with L-glutamine) (Quality Biological, 112-01-101CS) supplemented with 10% fetal ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	Western blot analysis of the expression level of CXCL7 protein in the CXCL7-KD and NC U266 (H)/RPMI8226 (I) cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western",...
PMC11725127	GA 1 μmol/L, isoalantolactone, lenalidomide, YL064, adenanthin, oridonin, bavachin, and isobavachalcone at 10 μmol/L, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11335267	Rather, the presence of Alx3 in neurons of the arcuate nucleus and the existence of systemic metabolic dysfunctions associated with altered hypothalamic responses to fasting and refeeding in Alx3-deficient mice likely reflects an important role of this transcription factor in the hypothalamus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11765988	The release of γ-IFN and TNF-α subsequently drives macrophage accumulation, activation, and clustering, leading to granulomatous inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "release", "of", ...
PMC10203589	It is no less progressive and harmful than other cancers, yet there are few available treatment options (72, 73).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC10142392	Furthermore, sequenced copolymers showed a notable improvement in transport.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "sequenced", "copolymers", "showed", "a", "notable", "improvement", "in", "tr...
PMC9429973	Results: As of December 7, 2021, 35 heavily pretreated NHL patients have received emavusertib monotherapy (median age 66 years, range 50-87), of which six patients have been on emavusertib for approximately 1 year or longer, suggesting emavusertib has a long-term acceptable safety and tolerability profile at RP2D (dose...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6650823	Recently, five differently substituted 2-hydroxybenzophenones were synthesized by a general scheme in which the 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane was a key step in the tuning of natural chromone scaffolds .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	ERK5 and CDK5 aside from mediating the activation of FAK, control multiple other signaling pathways, including STAT3 (Giurisato et al, 2018; Hwang and Namgung, 2021; Stecca and Rovida, 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	ChIP assay results revealed that NFATc1 can directly target the promoter regions of the PD-1 and CTLA-4 genes and promote their transcription.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChIP", "assa...
PMC11678368	The appearance of an additional band in the C=O stretching region for the 5ClL complexes is characteristic for the presence of trans configurations of the aldehyde group in the 5-chloro-substituted ligands.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	In our study, we measured the turbidity of fully grown IA fibrils at 600 nm and the turbidity of the IA sample incubated with ZnO-NFs for 24 h. The turbidity data shows that there was a significant decrease (60% degradation) in the turbidity of IA when they were incubated with ZnO-NFs (Fig. 7c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8010066	Based on the Fig. 2, the MIC of carbapenems decreases from 8–9 to 2–3 μg/mL in PA-2 and PA-3 in comparison to PA-4 (reduced from 9 to 5 μg/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Representative liver morphology and liver index of Mecp2 mice without (AAV-EV) or with (AAV-Mecp2) AAV-mediated Mecp2 overexpression at 7 d post-PHx.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11705067	Additionally, the protein expression of cuproptosis-related genes was verified in our collected ccRCC clinical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "protein", "expression", "o...
PMC11055323	as indicated in the figure legends.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "as", "indicated", "in", "the", "figure", "legends", "." ] } ]
PMC6684588	Corning BioCoat Matrigel Assay Plates (Corning, NY) were blocked with 200 μL/well 100% Pierce StartingBlock (VWR, Radnor, PA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9693627	Mitochondria quantity was estimated by measurement of total mitochondria protein concentration by Bradford assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondria", "quantity", "was", "estimated", "by", "measurement", "o...
PMC11764090	ACGT element-specific plant DNA-binding proteins belong to the bZip domain .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACGT", "element-specific", "plant", "DNA-binding", "proteins", "belong", "to", "the", "bZip", "d...
PMC11763126	D PCR analysis of USP5 mRNA levels after treatment with CBDP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "PCR", "analysis", "of", "USP5", "mRNA", "levels", "after", "treatment", "with", ...
PMC9429973	Results: As of March 5, 2021, 394 patients (318 [81%] FL gr1–3a; 76 [19%] MZL) were enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5833712	f Immunoprecipitation of p300, from lysates of A2780cis treated or not 1 h with 10 nM of KB9520; co-immunoprecipitated proteins were detected by Western blot analyses using the respective antibodies (p300, SIRT1, and ERβ) The standard of care for the management of advanced ovarian cancer has been unchanged for many yea...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7185206	We further hypothesized that high doses of PD-1 inhibitor may prevent sPD-L1-mediated CD8 + T cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "hypothesized", "that", "high", ...
PMC9429973	Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain Background: Hereditary pyruvate kinase (PK) deficiency is a known cause of rare anemia characterized by accelerated destruction of red blood cells in the spleen or hemolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	A comparison of the means among groups was performed using Mann-Whitney U test for body weight, tumor weight, and tumor volume data, or one-way analysis of variance (ANOVA) followed by Dunnett’s post-hoc test for IHC data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At the molecular level, the effect of Alpelisib was assessed by measuring PTEN expression levels and cell cycle regulating non-coding RNA molecules by using quantitative real-time polymerase chain reaction (qRT-PCR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	HEK293T cells expressing GFP‐tagged histone H2B protein were fixed, permeabilized, incubated with the freshly folded AP3‐RhoBAST aptamer, and then washed.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], ...
PMC7582629	The methodology developed allowed for unprecedented chemical characterization of fluorescently labeled biological tissues in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "methodology", "developed", "allowed", "for", "unprecedente...
PMC11593713	During the reaction, the oxidized glutathione (GSSG) is formed from GSH produced by glutathione reductase (GR) present in the reaction mixture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9143157

Platinum-containing regimens were commonly used with paclitaxel plus carboplatin (TC) for first-line ovarian cancer treatment, and pegylated liposomal doxorubicin (Doxil) plus carboplatin (PLD-C) is also used for recurrence .

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PMC11545868

Recently, Pessoa, J. et al. investigated how cytochrome c can be applied to the development of various anticancer therapies to optimize their apoptotic efficacy and stabilize them for targeted delivery to cancer cells .

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PMC10329074

First, YBX3 was found to be significantly expressed in the various types of cancer tissues analyzed, namely cholangiocarcinoma (CHOL) (P < 0.001), colon adenocarcinoma (COAD) (P < 0.05), esophageal carcinoma (ESCA) (P < 0.001), ccRCC (P < 0.001), renal papillary cell carcinoma (KIRP) (P < 0.001), lung squamous cell car...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9622879

To remove variable P(t), we introduce a new variable s(t), which is a binary variable that indicates the buying/selling status of the community from/to the EP at each time slot t.25[12pt] $$ s(t) = 1 & _^E_^(t) > _^E_^(t) \\ 0 & _^E_^(t) < _^E_^(t) . }

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11082662

The cells were then screened in DMEM medium supplemented with G418 (cat.

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PMC11204465

One new compound, dihydrodemethylsterigmatocystin (69), was isolated from Aspergillus versicolor .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "new", "compound", ",", "dihydrodemethylsterigmatocystin", "(", ...

PMC7305184

The results are shown as mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "are", "shown", "as", "mean", "±", "SD", "." ] } ]

PMC9429973

Image: Summary/Conclusion: We demonstrate: (i) that switching of TKI is frequent and mainly driven by intolerance in all lines of treatment; (ii) serial intolerance is 6.6 time more frequent than serial resistance suggesting a class effect for intolerance in some patients; (iii) all TKIs have a similar «retention level...

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PMC10669966

Data from the newest version of in silico transcriptomic (IST; ) database (MediSapiens Ltd., Helsinki, Finland) were fetched into R by using Dplyr extension for SQlite.

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PMC11001582

Expression of polyGR in human iPS cell neurons was sufficient to induce TGFB1 expression followed by COL6A1, and knockdown of the COL6A1 or TGFB1 homologs in flies expressing 36 GR repeats showed a specific and striking enhancement of neurodegeneration, pointing to a neuroprotective effect of collagen induction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Disease phase at transplant is an important risk factor for alloHCT outcomes.

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PMC11216402

Across cell lines, the expression of COL1A1 is highly correlated with the activity of the peaks COL1A1_E1 and COL1A1_E2 (r = 0.64 and 0.58) (Supplemental Figs. S21, S22).

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PMC11599565

Of note, the downregulation of E-Cadherin, the upregulation of N-Cadherin along with several associated proteins, appear to play paramount roles in epithelial—mesenchymal transition (EMT) making it a potentially targetable process in the treatment of OCs.

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PMC11683240

The cell lysate served as a source of Gαi.

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PMC11756514

Only a few papers have examined the interaction of SP-D with S. aureus.

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PMC11782508

The presence of azurin in the cell extract was confirmed using the CuCl₂ method.

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PMC8567602

F, Heat maps of ChIP-seq distributions around TSSs across the whole genome, ordered by enrichment for SMARCA4 in hSS2-only tumors.

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PMC11767582

The organic phase was dried over anhydrous Na2SO4 and the mixture was concentrated to dryness and purified by flash column chromatography on silica gel using mixtures of n-hexane and ethyl acetate as eluents.

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PMC11711347

According to a previous study by Eka Pratiwi et al. that examined Ni(II) complex activity on breast cancer cells, the Ni(II)cysteine-tyrosinedithiocarbamate complex exhibited lower cytotoxicity compared to cisplatin, as indicated by the IC50 values of the two compounds .

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PMC11441402

Quantifying drug cytotoxicity is a critical tool for broadening our understanding of cell biology and identifying new therapeutic compounds.

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PMC11286266

Selected pathways are ranked by p-value.

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PMC10999934

A gene at log2FC greater than 0.5 and an adjusted P value less than 0.05 was considered a DEG.

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PMC9429973

The overall 60-day mortality was 25.8%, with no death related to thrombosis.

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PMC11515150

Several preclinical studies of antibody-derived CAR-T cell therapies showed that binding membrane-proximal epitope had been revealed to enhance the immune effector function [17–20].

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PMC11591038

These earlier findings collectively revealed the link between hypoxia/ischemia and APP expression/processing that may contribute to AD pathogenesis.

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PMC11011837

However, differences in the ratios among the cell lines do not reach significance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "differences", "in", "the", "ratios", "among", "t...

PMC10656496

Coculture Panobinostat and trametinib treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coculture", "Panobinostat", "and", "trametinib", "treatment", "." ] } ]

PMC4659567

Finally, complex [Ru(η -p-cym)(L9)Cl2] containing mebendazole (L9) showed acute antitumor activity against HeLa cervical cancer cell line with IC50 = 0.20 μM .

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PMC11666785

In addition, we noted that localization precision is not strongly dependent on the degree of correlation.

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PMC9429973

There are also insufficient data to support the use of thrombolysis in patients with CVT, as only case-reports and patient-series have been published.

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PMC9429973

Response was assessed every 8 weeks from cycle 3, and every 12 weeks from cycle 13 and was measured according to the iwCLL 2018 criteria, including PR with lymphocytosis (PR-L).

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PMC11377827

G, H) Bioenergetic analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", ",", "H", ")", "Bioenergetic", "analysis", "." ] } ]

PMC11400680

Figure 3 demonstrates the detailed performance measurements of our prompt generator.

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PMC9429973

The mean neutralizing capacity in patients with MM or B-CLL was lower than in controls at all time points after the first vaccine dose.

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PMC11087766

Since PhiPA3 gp108 does not localize to the PhiKZ nucleus (Fig. 1A) but shares high sequence and structural homology to PhiKZ gp104 (Fig. 1G and SI Appendix, Fig. S1A), this approach allowed us to screen for sequence-specific localization effects while still maintaining the full sequence length and general structure of...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786767

Figure 4Relative distribution patterns of Ki-67, biotin-DHPE, and PS.

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PMC11429241

Despite this, owing to the usage of the material vat with a submerged substrate which was lifted away from the focusing optic after each layer, printing objects with a height higher than the free working distance was made possible.

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PMC10858941

In the last years, the key role of the microenvironment in tumour progression has been elucidated.

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PMC9429973

We recently detected a significant lower expression of NR4A1 that correlates with a poor lymphoma-specific survival.

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PMC11448304

a Quantification overview of identified modification sites and proteins from mass spectrometry.

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PMC11144200

Our observations revealed a significant increase in CD25, CD69, and CD62L expression in LPS-RGD-Nb36-DOX as well as DC/tumor fusion vaccine-activated CD8 T cells (P < 0.001) (Fig. 2B).

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PMC11540664

Patient baseline characteristics, such as age, sex, ECOG Score and AFP, were obtained from their electronic medical records.

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PMC11476666

Cells were seeded at a density of 1.2 × 10 cells per well in a 6-well plate, in the following two experimental conditions: pre- or postspheroids formation.

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PMC11437637

Normally distributed data were represented by mean ± standard deviation and differences between groups were analyzed via t-test.

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PMC11085211

Among them, nine maintained the pharmacological activity in GIST-882 and GIST-T1, suggesting that more than one phytochemical was responsible for the FR2-A effect.

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PMC10698968

To the best of our knowledge, few studies on the role of ribosome biogenesis in sarcomas have been conducted encouraging a deeper investigation of its possible role in myxofibrosarcoma pathogenesis.

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PMC11754432

7ALOX15B silencing alters membrane lipids.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "7ALOX15B", "silencing", "alters", "membrane", "lipids", "." ] } ]

PMC11794847

This incubation was performed for 30 min under light-protected conditions to ensure the stability and efficacy of the fluorochrome.

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PMC11787381

The run was performed according to manufacturer’s recommendations.

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PMC9611901

Keratin is the only protein found in hair and the second most abundant protein in leather.

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PMC10877303

Several potential vaccines are currently undergoing clinical and preclinical trials.

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PMC11541409

The NF1 gene encodes neurofibromin 1, which stimulates the GTPase activity of RAS and thus negatively regulates RAS/MAPK signaling pathway.

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PMC8345486

Ferra bis(dicarbollide) 2 was taken up by the cells in twice the amount of cobalt bis(dicarbollide) 1 (Figure 4B), but it was considerably less effective on cell viability.

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PMC11802855

The gene sets for these pathways were obtained from the MsiGDB database.

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PMC10788478

Additionally, mRNA sequencing was performed to compare the expression profiles of cells subjected to different treatments.

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PMC11772585

Fig. 2METTL1 knockdown significantly represses cSCC cells survival.

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PMC9429973

Aims: We recently identified SAMD9/9L mutations in 8% of children with MDS, and a strong association with monosomy 7 (EWOG-MDS; Sahoo et al, Nat Med, 2021).

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PMC11429241

For this reason, we decided not to perform any additional biocompatibility evaluation in this work.

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PMC11612626

After treatment with compound A, the relative number of the most upregulated peptides that terminated in either Tyr or Phe was consistent with an increase in immunoproteasome-specific activity (Fig. 5F).

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PMC9261184

The ship stopped to refuel with diesel in Portland, UK, on 15th April, and the ballast voyage lasted another 13 days to reach Corpus Christi on 28th April.

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PMC6948907

Asterisks (*) indicate significant differences between treated cells and the control group.

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PMC11248911

for C13H17N3S (247.36): C, 63.12; H, 6.93; N, 16.99; S, 12.96.

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PMC11363012

Therefore, these scMS and scRNA-seq data provide the foundation for the discovery of additional transporters.

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PMC9964635

Hemolytic activity was investigated by the reported method using Triton-X-100 as standard.

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PMC11470999

Quantitative analysis of the protein levels is also shown. (

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PMC9429973

Likewise, both the homozygotes for the minor alleles as well as the heterozygotes (CG/GG for Casp8, AT/TT for Casp10 and AG/GG for FAS) were associated with ALL in children and adolescents (Table 1).

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PMC5261804

Two PPIs are connected in the network if they share a protein, i.e., each edge in the new graph corresponds to a protein.

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PMC9964654

Aiming to provide water solubility, prolonged availability, and enhanced therapeutic indexes, BCMs loaded with [Au(cdc)2] were synthesized and characterized.

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PMC8711270

CEVEC pharmaceuticals have developed ELEVECTA® producer cell lines where AAV production genes are stably expressed in CEVEC’s amniocyte production (CAP) cells where gene expression is controlled by an inducible promoter.

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PMC10812665

The alterations in amino acid metabolism may not only serve a biomarker function, but they may be directly involved in the cell pathology (in addition to direct effects of c-I inhibitors on mitochondria); (ii) the abundance of NADH might drive some reactions, i.e., shift reaction balances in a way not found in healthy ...

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PMC11489351

RPMI 1640 (Corning, 10-040-CV) supplemented with 10% fetal bovine serum (Peak Serum, PS-FB2, lot 06C1182) and GlutaMAX (Thermo Fisher Scientific, 35050061) for a final glutamine concentration of 446 mg/L. Eagle's Minimal Essential Medium (with L-glutamine) (Quality Biological, 112-01-101CS) supplemented with 10% fetal ...

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PMC11802855

Western blot analysis of the expression level of CXCL7 protein in the CXCL7-KD and NC U266 (H)/RPMI8226 (I) cell lines.

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PMC11725127

GA 1 μmol/L, isoalantolactone, lenalidomide, YL064, adenanthin, oridonin, bavachin, and isobavachalcone at 10 μmol/L, respectively. (

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PMC11335267

Rather, the presence of Alx3 in neurons of the arcuate nucleus and the existence of systemic metabolic dysfunctions associated with altered hypothalamic responses to fasting and refeeding in Alx3-deficient mice likely reflects an important role of this transcription factor in the hypothalamus.

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PMC11765988

The release of γ-IFN and TNF-α subsequently drives macrophage accumulation, activation, and clustering, leading to granulomatous inflammation.

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PMC10203589

It is no less progressive and harmful than other cancers, yet there are few available treatment options (72, 73).

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PMC10142392

Furthermore, sequenced copolymers showed a notable improvement in transport.

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PMC9429973

Results: As of December 7, 2021, 35 heavily pretreated NHL patients have received emavusertib monotherapy (median age 66 years, range 50-87), of which six patients have been on emavusertib for approximately 1 year or longer, suggesting emavusertib has a long-term acceptable safety and tolerability profile at RP2D (dose...

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PMC6650823

Recently, five differently substituted 2-hydroxybenzophenones were synthesized by a general scheme in which the 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane was a key step in the tuning of natural chromone scaffolds .

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PMC11473843

ERK5 and CDK5 aside from mediating the activation of FAK, control multiple other signaling pathways, including STAT3 (Giurisato et al, 2018; Hwang and Namgung, 2021; Stecca and Rovida, 2019).

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PMC8270637

ChIP assay results revealed that NFATc1 can directly target the promoter regions of the PD-1 and CTLA-4 genes and promote their transcription.

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PMC11678368

The appearance of an additional band in the C=O stretching region for the 5ClL complexes is characteristic for the presence of trans configurations of the aldehyde group in the 5-chloro-substituted ligands.

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PMC11684297

In our study, we measured the turbidity of fully grown IA fibrils at 600 nm and the turbidity of the IA sample incubated with ZnO-NFs for 24 h. The turbidity data shows that there was a significant decrease (60% degradation) in the turbidity of IA when they were incubated with ZnO-NFs (Fig. 7c).

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PMC8010066

Based on the Fig. 2, the MIC of carbapenems decreases from 8–9 to 2–3 μg/mL in PA-2 and PA-3 in comparison to PA-4 (reduced from 9 to 5 μg/mL).

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PMC11095939

Representative liver morphology and liver index of Mecp2 mice without (AAV-EV) or with (AAV-Mecp2) AAV-mediated Mecp2 overexpression at 7 d post-PHx.

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PMC11705067

Additionally, the protein expression of cuproptosis-related genes was verified in our collected ccRCC clinical samples.

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PMC11055323

as indicated in the figure legends.

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PMC6684588

Corning BioCoat Matrigel Assay Plates (Corning, NY) were blocked with 200 μL/well 100% Pierce StartingBlock (VWR, Radnor, PA).

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PMC9693627

Mitochondria quantity was estimated by measurement of total mitochondria protein concentration by Bradford assay.

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PMC11764090

ACGT element-specific plant DNA-binding proteins belong to the bZip domain .

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PMC11763126

D PCR analysis of USP5 mRNA levels after treatment with CBDP1.

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PMC9429973

Results: As of March 5, 2021, 394 patients (318 [81%] FL gr1–3a; 76 [19%] MZL) were enrolled.

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PMC5833712

f Immunoprecipitation of p300, from lysates of A2780cis treated or not 1 h with 10 nM of KB9520; co-immunoprecipitated proteins were detected by Western blot analyses using the respective antibodies (p300, SIRT1, and ERβ) The standard of care for the management of advanced ovarian cancer has been unchanged for many yea...

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PMC7185206

We further hypothesized that high doses of PD-1 inhibitor may prevent sPD-L1-mediated CD8 + T cell death.

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PMC9429973

Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain Background: Hereditary pyruvate kinase (PK) deficiency is a known cause of rare anemia characterized by accelerated destruction of red blood cells in the spleen or hemolysis.

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PMC10589262

A comparison of the means among groups was performed using Mann-Whitney U test for body weight, tumor weight, and tumor volume data, or one-way analysis of variance (ANOVA) followed by Dunnett’s post-hoc test for IHC data.

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PMC9429973

At the molecular level, the effect of Alpelisib was assessed by measuring PTEN expression levels and cell cycle regulating non-coding RNA molecules by using quantitative real-time polymerase chain reaction (qRT-PCR).

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PMC11627133

HEK293T cells expressing GFP‐tagged histone H2B protein were fixed, permeabilized, incubated with the freshly folded AP3‐RhoBAST aptamer, and then washed.

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PMC7582629

The methodology developed allowed for unprecedented chemical characterization of fluorescently labeled biological tissues in vivo .

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PMC11593713

During the reaction, the oxidized glutathione (GSSG) is formed from GSH produced by glutathione reductase (GR) present in the reaction mixture.

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