OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11473843	After selection, the shRNA in the Tet-pLKO-puro was induced with 1 μg/mL doxycycline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "selection", ",", "the", "shRNA", "in", "the", "Tet-pLKO...
PMC7887261	Notably, 14/25 candidates we identified were frameshift deletions that result in either truncated proteins or nonsense-mediated mRNA decay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "14/25", "candidat...
PMC9429973	E. Kastritis, G. Palladini, M. A. Dimopoulos, A. Jaccard, G. Merlini, F. Theodorakakou, D. Fotiou, M. C. Minnema, A. Wechalekar, S. Gkolfinopoulos, K. Manousou, P. Sonneveld, S. Schönland Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece; Amyloidosis...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The safety committee recommended performing an early (day 14-21) bone marrow assessment in cycle 1, leading to VEN interruption in case of aplastic morphology with grade 4 neutropenia or thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	We tested whether the addition of a DNMTi could allow use of lower dose PARPi, using colony formation assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "tested", "whether", ...
PMC11703992	It has specific GAP (enzyme activating protein) activity in Rac1, which negatively regulates Rac1 by promoting GTP hydrolysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "spec...
PMC11126803	In particular, many LncRNAs have been revealed to play an important role in tumor growth and metastasis, including lung, breast, liver, and colorectal cancers (29, 30, 31), as well as hematological malignancies, and neuroblastoma (32, 33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11106977	O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transferase (OGT) and O‑GlcNAcase (OGA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "O-GlcNAcylation", "leve...
PMC9559528	Despite the absence of the typical triggers, our patient presented with a classic appearance of EM-like targetoid lesions with distinct borders and three concentric zones: an erythematous, dusky, and sometimes crusted or blistered center; a surrounding pale, edematous ring; and a pale erythematous periphery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: This is an open-label, multiarm, multicenter study that includes 3 safety run-ins with corresponding phase 2 cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "T...
PMC10033453	Body weight was measured 3 times per week for a total of 49 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Body", "weight", "was", "measured", "3", "times", "per", "week",...
PMC9429973	Summary/Conclusion: An early identification of severe lymphoid abnormality could represent a high risk factor for poor outcomes with COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "A...
PMC11806106	The agonist-induced activation was normalized to the maximal activation (mean ± SEM, n = 3 of independent transfections measured in triplets) and plotted as concentration-response curve for nociceptin in E (EC50: 63 nM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11577421	First, we observed that NP uptake in untreated HeLa cells was approximately 10-fold higher for NP_BSA+ than NP_BSA, consistent with findings in CHO-K1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC11569208	786-0 cells were selected as the cellular model given its natural resistance to VSV∆51 infection, which would highlight any phosphatases that would enhance VSV∆51 infectivity upon knockdown.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC9429973	Cohort 1 is a safety lead-in dose-finding in patients with relapsed/refractory (RR) disease, with a 3-by-3 design to establish the recommended phase 2 dose (RP2D) for EO2463 monotherapy and to confirm the safety of the RP2D for combination schedules of EL, and ER.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	Using data from the 1000 Genomes Project, we identified two common SNPs within the upstream region: rs365052 (G/C 66:33%) and rs2747429 (C/T 27:73%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Efficacy was analyzed by comparing the response registered at the latest time point (34 pts evaluable) or at 3 months (27 pts evaluable – we excluded those patients for whom molecular analysis was not assessed) vs the response at baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8753818	Growth characteristics of native CHO-K1 and CHO-KO cells are shown in Fig. 1a, b. The growth rate of these two cell lines was comparable for 4 days, with average doubling times of 20 h for the native CHO-K1 cell line and 26 h for the CHO-KO cells.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11628309	SH-SY5Y does acquire neuronal phenotypes with different differentiation compounds and protocols, such as retinoic acid (RA), staurosporine (Stau), phorbol esters, brain-derived neurotrophic factor (BDNF), among others (Carvajal-Oliveros et al., 2022; Filograna et al., 2015).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774251	Additionally, Tan-I interfered with cell cycle advancement by promoting G1 phase accumulation while decreasing G2/M phase entry (Figure 3C–F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11394730	RV blocked the mevalonate pathway in rat theca-interstitial cells, lowered HMGCR expression and activity, and decreased cholesterol production .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RV", "blocked", "the", ...
PMC9429973	However, resistance to Ven in both MCL and other lymphomas is being observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "resistance", "to", "Ven", "in", "both", "MCL", ...
PMC9386809	The Zr metal lies at 2.091 Å from the plane of the calixarene ring.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Zr", "metal", "lies", "at", "2.091", "Å", "from", "...
PMC9325715	More precisely secondary structure can be outlined on amide III modes, which mainly come from CN str.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "precisely", "secondary", "structure"...
PMC11361748	For acute UVB treatment, mice were anesthetized with isoflurane and put in a dark cabinet equipped with 4 UVB lamps (305 to 312 nm) (Daavlin Distributing Company).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087055	In contrast, the analyses of the cell flow in the Vg1/COS implanted embryos illustrated the disruption of the authentic polonaise movements at the extending authentic PS (Figure 3F–F”’, H–H”’ and J–J”’, Fig. S5, and Video 3, n=4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	CellMask Orange (Thermo Fischer Scientific, Eugene, OR, USA) was added and further incubated for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CellMask", "Orange", ...
PMC8751435	Caspase‐3 inhibitor Ac‐DEVD‐CHO (Ac‐DC) is employed to validate caspase‐3‐dependent effect and mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase‐3", "inhibitor", "Ac‐DEVD‐CHO", "(", "Ac‐DC", ")", "is", ...
PMC11078693	Drying cells on a slide, with or without heating, is often involved to facilitate this attachment, after which suspension cells are processed similarly to adherent ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	Intriguingly, probably due to CD47 upregulation, long-term incubation with TKIs provided higher levels of phagocytosis in both solid cancer subtypes, reporting a significant improvement in phagocytosis in the off-target resistant setting as well (i.e., H3122-LR100, CLB-Ga-LR1000; Figure 2D,E and Figure 3C, left and rig...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Four children carrying variants in the CARD11 gene presented with MF as initial sign of the disease (n=2) or with immune cytopenias further evolving into MF (n=2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	Our analysis revealed 15 differentially expressed miRNAs in PCOS, many of which were also associated with UCEC prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "analysis", "revealed", "15...
PMC11790599	Red arrows indicating the formation of vacuoles. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "arrows", "indicating", "the", "formation", "of", "vacuoles", ".", "(" ] } ]
PMC10391797	ANOVA, analysis of variance; CAR, chimeric antigen receptor T; HDACi, histone deacetylases inhibitor; NKG2D, natural-killer group 2 member D THP-1 and MV411 were pretreated with a low dose of HDACi for 24 hours or 48 hours; then, the washed tumor cells were co-cultured with CAR-T for 24 hours or 48 hours at a 1:5 E/T r...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC11640419	The Jurkat cell line was selected for investigation into the intracellular signaling of genotoxicity and the induction of apoptosis.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Jurkat", "cell", ...
PMC6684588	SPR assays were carried out for ACE-083 more than three times, and these data represent means of two experiments performed on separate flow cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11536589	These alterations lead to an increase in the quantities of active KRAS protein coupled to GTP and might hinder the effectiveness of drug binding (Awad et al. 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	While generating the new prognostic score – Cerrahpaşa CML Prognostic Score (CCPS), uni- and multivariate Cox regression analysis were performed in order to identify factors having an impact on progression and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Anti-PRAP1 (Proteintech, 11932-1-AP), anti-GSDME (Abcam, ab222408), anti-β-actin (Absin, abs830031), and DyLight-modified anti-rabbit IgG (H+L) (Cell Signaling Technology, 5151) were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	We therefore hypothesized that BMP3 expression may be reduced in biliary cancers, resulting in a lack of tumor suppressor function due to aberrant BMP3 promoter methylation, and that methylated BMP3 may serve as a clinically useful biomarker in these cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	Tang and Cao 2022) discovered that curcumin can reduce SOX10 gene expression by upregulating the expression level of miRNA-222-3p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tang", "and"...
PMC11695546	The mixture was then rotated at 12,000×g for fifteen minutes at 5°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "then", "rotated", "at", ...
PMC11474209	Sun et al. developed a similar immunosensor for MC-LR screening using immunochromatographic test strips (ICTS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sun", "et", "al.", "developed", "a", "simil...
PMC11533140	In addition, in an apoptosis assay, 17p could induce dose-dependent cytotoxicity in the ovarian cancer cell line A2780.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O" ], "tokens": [ ...
PMC11590005	If so, it is important to devise political initiatives to support opportunities for non-whites to have increased access to private dental schools .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", ...
PMC10170482	The soft 3D microenvironment increases fission and leads to marked depolarization of mitochondria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "soft", "3D", "microenvironment", "increases", "fission", "and", "lea...
PMC11680578	Table 1 shows different CI values at different concentrations of RGZ and PTX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1", "shows", "different", "CI", "values", "at", "different", ...
PMC9684669	In a second attempt, tannic acid (TA), a blocker of the hERG channel, was recruited (40).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11750696	Upon the activation of TCR signaling, ER stress and the UPR are integral to the balance and expansion of T cell populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", ...
PMC10919056	OS analysis between the high-RS score group and low-RS score group. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OS", "analysis", "between", "the", "high-RS", "score", "group", "and", "low-RS",...
PMC11389534	The UFMylated substrates are cleaved mainly by UFSP2, which is a major de‐UFMylation enzyme of the pathway, and forms a complex with ODR4 to localise to the ER.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A high unmet need exists to build on current standard-of-care AZA frontline therapy to increase efficacy while maintaining a tolerable safety profile in patients (pts) with HR MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8735881	Thus, TZM-bl cells were transduced with GPI-scFvs as target cells and then cocultured with HIV-infected donor cells (CEMss-CCR5 cells) without addition of DEAE-dextran.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC9429973	Aims: The randomized double-blind placebo-controlled HOVON-113 trial was designed as an international effort to evaluate whether addition of MSC to standardized second line treatment of SR-aGVHD improves clinical outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806106	Increasing concentrations of nociceptin were applied followed by a saturating concentration of nociceptin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increasing", "concentrations", "of", "nociceptin", "were", "applied", "followed",...
PMC4839679	ccRCC is characterized by a metabolic shift mediated through altered hypoxic signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ccRCC", "is", "characterized", "by", "a", "metabolic", "shift", "mediated", "thr...
PMC11252033	mRNA was purified from total RNA using poly-T oligo-attached magnetic beads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mRNA", "was", "purified", "from", "total", "RNA", "using", "poly-T", "oligo-attached", ...
PMC11576293	Generally, compounds with MW below 500 g/mol and TPSA less than 140 Ȧ2 could transfix through membranes easily, rapidly and subsequently will have less undesirable side effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11753949	Synaptopodin is an actin-binding protein and, accordingly, the spine apparatus and cisternal organelle are localized in actin rich regions of dendritic spines and axonal initial segments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508	Using the unsubstituted N-(2-(2-phenyl-2H-tetrazol-5-yl)phenyl)-benzamide 70 as lead structure, 38 new derivatives with several modifications of the three phenyl rings (A, B, C) have been synthesized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11626627	Therefore, we hypothesize that the circATP2B1/miR-204–3p axis may contribute to the progression of ccRCC by promoting EMT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "hypothesize", ...
PMC9429973	Chronic GVHD was significantly reduced in haplo-cord with a cumulative incidence of 5.7% vs 28.6% in haplo patients by 1 year (P =0.04), but no extensive chronic GVHD was observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11555465	The experimental groups exhibited a decrease in cell quantity, reduced cell volume, wrinkled cells, decreased nuclear-cytoplasmic ratios and apoptosis, including nuclear condensation and rupture (Fig. 1B and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5311252	The 3.7–4.9 immobilized pH gradient strip was rehydrated in 8 M urea, 1% pharmalyte for pH range 2.5–5 (GE Healthcare).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: Primary tumor cells from seven patients with acute myeloid leukemia (AML) were transplanted into immunocompromised NSG mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "P...
PMC9275501	Guo et al. (2020a) developed a novel NM as an oral 5-FU and CUR synergistic delivery system (CUR/5-FU-NM) for synergistic treatment of liver cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721277	Consequently, the test involving the blocking of tumor cell receptors with excess studied substance was deemed unnecessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "the", "test", "in...
PMC11783017	Ⅰ: Control, Ⅱ: Lipo-IL11, Ⅲ: Mn@Lipo-IL11, Ⅳ: Cis/Mn@Lipo-IL11, Ⅴ: Cis/Mn@Lipo-IL11+NH, Ⅵ: Cis/Mn/NH@PGP.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ⅰ", ...
PMC11760643	Of importance to the current study is the classical complement pathway, which is activated by the binding of the complement C1 complex with regions of IgG or IgM antibody–antigen complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11657695	C CCN2 and CCN1 normalized gene expression in A-673 cell line (N = 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "CCN2", "and", "CCN1", "normalized", "gen...
PMC11764090	The impact of cold injury on plants depends on a variety of factors, including the intensity and duration of the cold injury, the stage of plant development at which cold injury occurs, and plant characteristics such as root structure, cuticle wax composition, and cell wall thickness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	These findings are consistent with the view that a RHBDF1-importin β1-PKCζ protein complex is involved in RHBDF1-facilitated nuclear translocation of PKCζ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", ...
PMC11487720	BCD was initially defined as “the formation of a single bubble from the nucleus per cell and release of this swelling bubble from the cell surface to extracellular space that irreversibly causes cell death” .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	The knockdown of METTL1 led to a decrease in the m7G enrichment of the ATF4 mRNA in both cell lines, while other genes remained unaffected (Fig. 5E and Supplementary Fig. S4A, B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	Genetic variation affects the expression level (Montgomery et al., 2010; Pickrell et al., 2010; Stranger et al., 2007) of the majority of human genes (Battle et al., 2017; Lappalainen et al., 2013; Storey et al., 2007).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593713	Oxidative stress might be triggered by a wide variety of viral infections: HIV 1; hepatitis viruses B, C, and D; herpes viruses; and respiratory viruses, such as coronaviruses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	No thrombotic events occurred in this patient population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "thrombotic", "events", "occurred", "in", "this", "patient", "population", "." ] } ]
PMC11727000	As expected, based on known interaction data, USP44 formed a cluster with NCOR1 and NCOR2, as well as CETN2 and CETN3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Image: Summary/Conclusion: Fewer than 10% of patients with severe SCD with at least 2 VOCs per year in the prior 2 years at baseline became VOC-free for 1 year with SOC in this nationwide cohort of Medicaid enrollees.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: To assess the impact of Ibrutinb on c-Fos transcription, we evaluated its expression in CLL cells treated with Ibrutinib or vehicle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10454535	MM’s challenging symptoms significantly impact people’s lives and survival, but MM is a disease that remains without a cure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MM", "’s", ...
PMC11367146	8Secondary structure analysis of (A) apo-BCL2 (B) BCL2-daucosterol (C) BCL2-gigantol complex (D) apo-ESR1 (E) ESR1-daucosterol (F) ESR1-gigantol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	The data were obtained through an Attune acoustic focusing flow cytometer (ThermoFisher Scientific) and respective software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "obtained", "thr...
PMC6889484	It is desirable to transduce activated CD4 T cells, the natural targets of HIV-1 infection, and CD34 HSPCs, which can differentiate to form new CD4 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680562	Ltd. Mumbai.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "Ltd.", "Mumbai", "." ] } ]
PMC11515150	Flow cytometry analysis of CD5 CAR expression on CAR-NK cells versus NT-NK cells on day 14. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "analysis", "of", "CD5", ...
PMC11617590	Cell titer 96 Aqueous One Solution cell proliferation assay kit used for cell viability was purchased from Promega (Madison, WI, USA), and The Muse Annexin V & Dead Cell kit used for apoptosis was purchased from Luminex (Austin, TX, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Other non-Thoeris TIR domain-containing proteins have also been implicated in a cGAS-like pathway in bacteria termed the “CBASS” pathway which also blocks phage replication .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9325715	More intense light absorption is connected to ligand-to-metal charge transfer and was detected at ≈ 280 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "intense", "light", "absorption", "is", ...
PMC5925824	5LY3300054 demonstrates anti-tumor efficacy in xenograft tumor models reconstituted with human immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5LY3300054", "demonstrates", "anti-tumor", "efficacy", "in", "xenograft", "tumor"...
PMC9429973	Confocal microscopy for intracellular compartment of hemolysate-treated HUVECs demonstrated that while the CD235a+ Hb+ particles were only found in whole hemolysate conditions, the Hb was detected similarly in all conditions tested.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991	E-cadherin-red; TRPV4-green; DAPI-blue.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "E-cadherin-red", ";", "TRPV4-green", ";", "DAPI-blue", "." ] } ]
PMC11422497	Additionally, we constructed overexpression and knockdown lentiviral vectors, as well as negative control (NC) vectors for circ_SMA4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", ...
PMC11640419	The human cell lines Jurkat, K562, U937, and HEK293 were obtained from the European Collection of Authenticated Cell Cultures (ECACC) and subsequently cultured in accordance with established standard protocols and sterile techniques.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There were 25 (27.8%) patients presenting high-risk cytogenetic abnormalities by FISH, defined as the presence of at least one of t (4;14), t (14;16) or del (17p).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	Although gene-edited universal CAR-T cells can address issues such as tumor contamination, GvHD, and allograft rejection, the risk of genotoxicity associated with the CRISPR/Cas9 system should not be overlooked .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11760643	B, D) Ca response traces were normalised to baseline (0–30 s) and the area under the curve from 100 to 180 s was used as a measure of the P2X7‐mediated Ca flux. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Furthermore, in recognition of the fact that clonal evolution may occur in MDS patients, consideration should be given to repeating the chromosome analysis as the most important prognostic factor at regular intervals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	The constructs comprising tumor cells, HUVECs, and fibroblasts were treated with laser inducible capsules of signaling molecules such as EGF and VEGF to create a chemical gradient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11473843

After selection, the shRNA in the Tet-pLKO-puro was induced with 1 μg/mL doxycycline.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "selection", ",", "the", "shRNA", "in", "the", "Tet-pLKO...

PMC7887261

Notably, 14/25 candidates we identified were frameshift deletions that result in either truncated proteins or nonsense-mediated mRNA decay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "14/25", "candidat...

PMC9429973

E. Kastritis, G. Palladini, M. A. Dimopoulos, A. Jaccard, G. Merlini, F. Theodorakakou, D. Fotiou, M. C. Minnema, A. Wechalekar, S. Gkolfinopoulos, K. Manousou, P. Sonneveld, S. Schönland Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece; Amyloidosis...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The safety committee recommended performing an early (day 14-21) bone marrow assessment in cycle 1, leading to VEN interruption in case of aplastic morphology with grade 4 neutropenia or thrombocytopenia.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740508

We tested whether the addition of a DNMTi could allow use of lower dose PARPi, using colony formation assays.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "tested", "whether", ...

PMC11703992

It has specific GAP (enzyme activating protein) activity in Rac1, which negatively regulates Rac1 by promoting GTP hydrolysis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "spec...

PMC11126803

In particular, many LncRNAs have been revealed to play an important role in tumor growth and metastasis, including lung, breast, liver, and colorectal cancers (29, 30, 31), as well as hematological malignancies, and neuroblastoma (32, 33).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11106977

O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transferase (OGT) and O‑GlcNAcase (OGA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "O-GlcNAcylation", "leve...

PMC9559528

Despite the absence of the typical triggers, our patient presented with a classic appearance of EM-like targetoid lesions with distinct borders and three concentric zones: an erythematous, dusky, and sometimes crusted or blistered center; a surrounding pale, edematous ring; and a pale erythematous periphery .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Methods: This is an open-label, multiarm, multicenter study that includes 3 safety run-ins with corresponding phase 2 cohorts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "T...

PMC10033453

Body weight was measured 3 times per week for a total of 49 days.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Body", "weight", "was", "measured", "3", "times", "per", "week",...

PMC9429973

Summary/Conclusion: An early identification of severe lymphoid abnormality could represent a high risk factor for poor outcomes with COVID-19.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "A...

PMC11806106

The agonist-induced activation was normalized to the maximal activation (mean ± SEM, n = 3 of independent transfections measured in triplets) and plotted as concentration-response curve for nociceptin in E (EC50: 63 nM).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11577421

First, we observed that NP uptake in untreated HeLa cells was approximately 10-fold higher for NP_BSA+ than NP_BSA, consistent with findings in CHO-K1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...

PMC11569208

786-0 cells were selected as the cellular model given its natural resistance to VSV∆51 infection, which would highlight any phosphatases that would enhance VSV∆51 infectivity upon knockdown.

[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...

PMC9429973

Cohort 1 is a safety lead-in dose-finding in patients with relapsed/refractory (RR) disease, with a 3-by-3 design to establish the recommended phase 2 dose (RP2D) for EO2463 monotherapy and to confirm the safety of the RP2D for combination schedules of EL, and ER.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11650848

Using data from the 1000 Genomes Project, we identified two common SNPs within the upstream region: rs365052 (G/C 66:33%) and rs2747429 (C/T 27:73%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Efficacy was analyzed by comparing the response registered at the latest time point (34 pts evaluable) or at 3 months (27 pts evaluable – we excluded those patients for whom molecular analysis was not assessed) vs the response at baseline.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8753818

Growth characteristics of native CHO-K1 and CHO-KO cells are shown in Fig. 1a, b. The growth rate of these two cell lines was comparable for 4 days, with average doubling times of 20 h for the native CHO-K1 cell line and 26 h for the CHO-KO cells.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11628309

SH-SY5Y does acquire neuronal phenotypes with different differentiation compounds and protocols, such as retinoic acid (RA), staurosporine (Stau), phorbol esters, brain-derived neurotrophic factor (BDNF), among others (Carvajal-Oliveros et al., 2022; Filograna et al., 2015).

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PMC11774251

Additionally, Tan-I interfered with cell cycle advancement by promoting G1 phase accumulation while decreasing G2/M phase entry (Figure 3C–F).

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PMC11394730

RV blocked the mevalonate pathway in rat theca-interstitial cells, lowered HMGCR expression and activity, and decreased cholesterol production .

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PMC9429973

However, resistance to Ven in both MCL and other lymphomas is being observed.

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PMC9386809

The Zr metal lies at 2.091 Å from the plane of the calixarene ring.

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PMC9325715

More precisely secondary structure can be outlined on amide III modes, which mainly come from CN str.

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PMC11361748

For acute UVB treatment, mice were anesthetized with isoflurane and put in a dark cabinet equipped with 4 UVB lamps (305 to 312 nm) (Daavlin Distributing Company).

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PMC11087055

In contrast, the analyses of the cell flow in the Vg1/COS implanted embryos illustrated the disruption of the authentic polonaise movements at the extending authentic PS (Figure 3F–F”’, H–H”’ and J–J”’, Fig. S5, and Video 3, n=4).

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PMC10890307

CellMask Orange (Thermo Fischer Scientific, Eugene, OR, USA) was added and further incubated for 5 min.

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PMC8751435

Caspase‐3 inhibitor Ac‐DEVD‐CHO (Ac‐DC) is employed to validate caspase‐3‐dependent effect and mechanism.

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PMC11078693

Drying cells on a slide, with or without heating, is often involved to facilitate this attachment, after which suspension cells are processed similarly to adherent ones.

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PMC11673128

Intriguingly, probably due to CD47 upregulation, long-term incubation with TKIs provided higher levels of phagocytosis in both solid cancer subtypes, reporting a significant improvement in phagocytosis in the off-target resistant setting as well (i.e., H3122-LR100, CLB-Ga-LR1000; Figure 2D,E and Figure 3C, left and rig...

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PMC9429973

Results: Four children carrying variants in the CARD11 gene presented with MF as initial sign of the disease (n=2) or with immune cytopenias further evolving into MF (n=2).

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PMC11806182

Our analysis revealed 15 differentially expressed miRNAs in PCOS, many of which were also associated with UCEC prognosis.

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PMC11790599

Red arrows indicating the formation of vacuoles. (

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PMC10391797

ANOVA, analysis of variance; CAR, chimeric antigen receptor T; HDACi, histone deacetylases inhibitor; NKG2D, natural-killer group 2 member D THP-1 and MV411 were pretreated with a low dose of HDACi for 24 hours or 48 hours; then, the washed tumor cells were co-cultured with CAR-T for 24 hours or 48 hours at a 1:5 E/T r...

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PMC11640419

The Jurkat cell line was selected for investigation into the intracellular signaling of genotoxicity and the induction of apoptosis.

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PMC6684588

SPR assays were carried out for ACE-083 more than three times, and these data represent means of two experiments performed on separate flow cells.

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PMC11536589

These alterations lead to an increase in the quantities of active KRAS protein coupled to GTP and might hinder the effectiveness of drug binding (Awad et al. 2021).

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PMC9429973

While generating the new prognostic score – Cerrahpaşa CML Prognostic Score (CCPS), uni- and multivariate Cox regression analysis were performed in order to identify factors having an impact on progression and survival.

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PMC11770199

Anti-PRAP1 (Proteintech, 11932-1-AP), anti-GSDME (Abcam, ab222408), anti-β-actin (Absin, abs830031), and DyLight-modified anti-rabbit IgG (H+L) (Cell Signaling Technology, 5151) were used.

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PMC4112127

We therefore hypothesized that BMP3 expression may be reduced in biliary cancers, resulting in a lack of tumor suppressor function due to aberrant BMP3 promoter methylation, and that methylated BMP3 may serve as a clinically useful biomarker in these cancers.

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PMC11727062

Tang and Cao 2022) discovered that curcumin can reduce SOX10 gene expression by upregulating the expression level of miRNA-222-3p.

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PMC11695546

The mixture was then rotated at 12,000×g for fifteen minutes at 5°C.

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PMC11474209

Sun et al. developed a similar immunosensor for MC-LR screening using immunochromatographic test strips (ICTS).

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PMC11533140

In addition, in an apoptosis assay, 17p could induce dose-dependent cytotoxicity in the ovarian cancer cell line A2780.

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PMC11590005

If so, it is important to devise political initiatives to support opportunities for non-whites to have increased access to private dental schools .

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PMC10170482

The soft 3D microenvironment increases fission and leads to marked depolarization of mitochondria.

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PMC11680578

Table 1 shows different CI values at different concentrations of RGZ and PTX.

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PMC9684669

In a second attempt, tannic acid (TA), a blocker of the hERG channel, was recruited (40).

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PMC11750696

Upon the activation of TCR signaling, ER stress and the UPR are integral to the balance and expansion of T cell populations.

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PMC10919056

OS analysis between the high-RS score group and low-RS score group. (

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PMC11389534

The UFMylated substrates are cleaved mainly by UFSP2, which is a major de‐UFMylation enzyme of the pathway, and forms a complex with ODR4 to localise to the ER.

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PMC9429973

A high unmet need exists to build on current standard-of-care AZA frontline therapy to increase efficacy while maintaining a tolerable safety profile in patients (pts) with HR MDS.

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PMC8735881

Thus, TZM-bl cells were transduced with GPI-scFvs as target cells and then cocultured with HIV-infected donor cells (CEMss-CCR5 cells) without addition of DEAE-dextran.

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PMC9429973

Aims: The randomized double-blind placebo-controlled HOVON-113 trial was designed as an international effort to evaluate whether addition of MSC to standardized second line treatment of SR-aGVHD improves clinical outcome.

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PMC11806106

Increasing concentrations of nociceptin were applied followed by a saturating concentration of nociceptin.

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PMC4839679

ccRCC is characterized by a metabolic shift mediated through altered hypoxic signaling.

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PMC11252033

mRNA was purified from total RNA using poly-T oligo-attached magnetic beads.

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PMC11576293

Generally, compounds with MW below 500 g/mol and TPSA less than 140 Ȧ2 could transfix through membranes easily, rapidly and subsequently will have less undesirable side effects.

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PMC11753949

Synaptopodin is an actin-binding protein and, accordingly, the spine apparatus and cisternal organelle are localized in actin rich regions of dendritic spines and axonal initial segments.

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PMC8992508

Using the unsubstituted N-(2-(2-phenyl-2H-tetrazol-5-yl)phenyl)-benzamide 70 as lead structure, 38 new derivatives with several modifications of the three phenyl rings (A, B, C) have been synthesized.

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PMC11626627

Therefore, we hypothesize that the circATP2B1/miR-204–3p axis may contribute to the progression of ccRCC by promoting EMT.

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PMC9429973

Chronic GVHD was significantly reduced in haplo-cord with a cumulative incidence of 5.7% vs 28.6% in haplo patients by 1 year (P =0.04), but no extensive chronic GVHD was observed.

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PMC11555465

The experimental groups exhibited a decrease in cell quantity, reduced cell volume, wrinkled cells, decreased nuclear-cytoplasmic ratios and apoptosis, including nuclear condensation and rupture (Fig. 1B and C).

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PMC5311252

The 3.7–4.9 immobilized pH gradient strip was rehydrated in 8 M urea, 1% pharmalyte for pH range 2.5–5 (GE Healthcare).

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PMC9429973

Methods: Primary tumor cells from seven patients with acute myeloid leukemia (AML) were transplanted into immunocompromised NSG mice.

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PMC9275501

Guo et al. (2020a) developed a novel NM as an oral 5-FU and CUR synergistic delivery system (CUR/5-FU-NM) for synergistic treatment of liver cancer.

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PMC11721277

Consequently, the test involving the blocking of tumor cell receptors with excess studied substance was deemed unnecessary.

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PMC11783017

Ⅰ: Control, Ⅱ: Lipo-IL11, Ⅲ: Mn@Lipo-IL11, Ⅳ: Cis/Mn@Lipo-IL11, Ⅴ: Cis/Mn@Lipo-IL11+NH, Ⅵ: Cis/Mn/NH@PGP.Fig.

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PMC11760643

Of importance to the current study is the classical complement pathway, which is activated by the binding of the complement C1 complex with regions of IgG or IgM antibody–antigen complexes.

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PMC11657695

C CCN2 and CCN1 normalized gene expression in A-673 cell line (N = 4).

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PMC11764090

The impact of cold injury on plants depends on a variety of factors, including the intensity and duration of the cold injury, the stage of plant development at which cold injury occurs, and plant characteristics such as root structure, cuticle wax composition, and cell wall thickness .

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PMC11587606

These findings are consistent with the view that a RHBDF1-importin β1-PKCζ protein complex is involved in RHBDF1-facilitated nuclear translocation of PKCζ.

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PMC11487720

BCD was initially defined as “the formation of a single bubble from the nucleus per cell and release of this swelling bubble from the cell surface to extracellular space that irreversibly causes cell death” .

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PMC11772585

The knockdown of METTL1 led to a decrease in the m7G enrichment of the ATF4 mRNA in both cell lines, while other genes remained unaffected (Fig. 5E and Supplementary Fig. S4A, B).

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PMC9844987

Genetic variation affects the expression level (Montgomery et al., 2010; Pickrell et al., 2010; Stranger et al., 2007) of the majority of human genes (Battle et al., 2017; Lappalainen et al., 2013; Storey et al., 2007).

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PMC11593713

Oxidative stress might be triggered by a wide variety of viral infections: HIV 1; hepatitis viruses B, C, and D; herpes viruses; and respiratory viruses, such as coronaviruses .

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PMC9429973

No thrombotic events occurred in this patient population.

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PMC11727000

As expected, based on known interaction data, USP44 formed a cluster with NCOR1 and NCOR2, as well as CETN2 and CETN3.

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PMC9429973

Image: Summary/Conclusion: Fewer than 10% of patients with severe SCD with at least 2 VOCs per year in the prior 2 years at baseline became VOC-free for 1 year with SOC in this nationwide cohort of Medicaid enrollees.

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PMC9429973

Methods: To assess the impact of Ibrutinb on c-Fos transcription, we evaluated its expression in CLL cells treated with Ibrutinib or vehicle.

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PMC10454535

MM’s challenging symptoms significantly impact people’s lives and survival, but MM is a disease that remains without a cure.

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PMC11367146

8Secondary structure analysis of (A) apo-BCL2 (B) BCL2-daucosterol (C) BCL2-gigantol complex (D) apo-ESR1 (E) ESR1-daucosterol (F) ESR1-gigantol.

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PMC10988555

The data were obtained through an Attune acoustic focusing flow cytometer (ThermoFisher Scientific) and respective software.

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PMC6889484

It is desirable to transduce activated CD4 T cells, the natural targets of HIV-1 infection, and CD34 HSPCs, which can differentiate to form new CD4 T cells.

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PMC11680562

Ltd. Mumbai.

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PMC11515150

Flow cytometry analysis of CD5 CAR expression on CAR-NK cells versus NT-NK cells on day 14. (

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PMC11617590

Cell titer 96 Aqueous One Solution cell proliferation assay kit used for cell viability was purchased from Promega (Madison, WI, USA), and The Muse Annexin V & Dead Cell kit used for apoptosis was purchased from Luminex (Austin, TX, USA).

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PMC11098378

Other non-Thoeris TIR domain-containing proteins have also been implicated in a cGAS-like pathway in bacteria termed the “CBASS” pathway which also blocks phage replication .

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PMC9325715

More intense light absorption is connected to ligand-to-metal charge transfer and was detected at ≈ 280 nm.

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PMC5925824

5LY3300054 demonstrates anti-tumor efficacy in xenograft tumor models reconstituted with human immune cells.

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PMC9429973

Confocal microscopy for intracellular compartment of hemolysate-treated HUVECs demonstrated that while the CD235a+ Hb+ particles were only found in whole hemolysate conditions, the Hb was detected similarly in all conditions tested.

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PMC10957991

E-cadherin-red; TRPV4-green; DAPI-blue.

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PMC11422497

Additionally, we constructed overexpression and knockdown lentiviral vectors, as well as negative control (NC) vectors for circ_SMA4.

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PMC11640419

The human cell lines Jurkat, K562, U937, and HEK293 were obtained from the European Collection of Authenticated Cell Cultures (ECACC) and subsequently cultured in accordance with established standard protocols and sterile techniques.

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PMC9429973

There were 25 (27.8%) patients presenting high-risk cytogenetic abnormalities by FISH, defined as the presence of at least one of t (4;14), t (14;16) or del (17p).

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PMC11604015

Although gene-edited universal CAR-T cells can address issues such as tumor contamination, GvHD, and allograft rejection, the risk of genotoxicity associated with the CRISPR/Cas9 system should not be overlooked .

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PMC11760643

B, D) Ca response traces were normalised to baseline (0–30 s) and the area under the curve from 100 to 180 s was used as a measure of the P2X7‐mediated Ca flux. (

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PMC9429973

Furthermore, in recognition of the fact that clonal evolution may occur in MDS patients, consideration should be given to repeating the chromosome analysis as the most important prognostic factor at regular intervals.

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PMC8557138

The constructs comprising tumor cells, HUVECs, and fibroblasts were treated with laser inducible capsules of signaling molecules such as EGF and VEGF to create a chemical gradient.

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