OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC11721096	1 and Fr.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "1", "and", "Fr", "." ] } ]
PMC11604768	TF binding motifs included in the initial screening library were selected from a published set of position weight matrices (PWMs) derived for 411 human and mouse TFs using HT-SELEX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11424574	Wu et al. found that COX2 knockdown in OS-732 cells significantly inhibited uPA expression and their invasiveness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wu", "et", "al.", "found", "that", ...
PMC11650848	Spliced junctions represented as red bars; arcs display the number of reads split across the junction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spliced", "junctions", "represented", "as", "red"...
PMC9596868	Images for PA-1 were acquired on a Vert.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "for", "PA-1", "were", "acquired", "on", "a", "Vert", "." ] } ]
PMC11696576	AX048 (7, Fig. 1) exhibited an antihyperalgesic effect in rats, blocking prostaglandin E2 (PGE2) release evoked by substance P. Among a series of 1-heteroarylpropan-2-ones, compound 8 (Fig. 1) was found to be a highly potent inhibitor of cPLA2α.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10887351	The authors observed that apigenin inhibited the antioxidant protein expression, such as superoxide dismutase-2, catalase, and thioredoxin, but it increased the UCP2 and GSH levels that, inversely, were strongly inhibited by β3-ARs antagonism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9874064	Unfortunately, the DNA repair machinary is powerful in cancer cells, resulting in resistance to platinum drugs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "the", "DNA", "re...
PMC11708541	The rotarod test and open field test behaviour index verified that 4-AP reduced the motor impairments brought on by MPTP 69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rotarod", ...
PMC11766309	YKT6 expression in the tumor tissue compared with corresponding paratumor tissue among the 33 tumors; (B) Mean expression of YKT6 in the 33 different tumor types based on the TCGA database; (C) Mean expression levels of YKT6 in different organs based on the GTEx database; (D) Mean expression levels in the diverse cance...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	Thus, in this experimental protocol, ERK1/2 phosphorylation does not correlate to platinum chemoresistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "in", "this", "experimental", "protocol", ",", ...
PMC3019555	More specifically, we found that 9% of total HIF-1α mRNA localized to P-bodies in control cells, whereas 64% and 70% of HIF-1α mRNA were found in P-bodies after treatment with 2ME2 or TX, respectively (Fig. 5 C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11344246	An alternate approach to identify protein drug targets is to map the protein-protein interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "alternate", "approach", "to", "identify", "protein", "drug", ...
PMC11626627	A recent study explored the molecular mechanisms by which TWIST1 suppresses E-cadherin expression to promote EMT, cancer cell migration, invasion, and metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8068766	GSEA results have revealed that the relatively upregulated genes in HepG2-2.2.15 cells were found to be more related to DNA-repair, G2M checkpoint, oxidation reduction, and MTORC1 signaling pathways, which might be key pathways for the acquired tolerance gained by HepG2-2.2.15 cells to Se-deficiency-dependent oxidative...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11727145	Our results indicated that cholera toxin and hydrocortisone could be omitted without affecting medium functionality on the DED constructs for cell seeding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "resul...
PMC3931643	We chose these cell lines from a larger panel of DLBCLs because they express BAX, BAK and BIM and are therefore have an intact apoptotic machinery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	Thus, there is still an unmet need for tools to precisely control biomolecular condensate dissolution in the complex environment of the cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ...
PMC11495567	(1:1000), KRAS (Cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "(", "1:1000", ")", ",", "KRAS", "(", "Cat", ".", "#" ] } ]
PMC11546117	Accessed 9 March 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accessed", "9", "March", "2021", ")", "." ] } ]
PMC9429973	In Japan, immediate post-cBTKi regimens were nearly exclusively chemotherapy based (n=92, 89.3%), and only 11 (10.7%) patients were retreated with cBTKi-containing regimens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	In response to Hh, both Gli2 and Sufu accumulate at ciliary tip and hindering Gli2 ciliary localization blocks its phosphorylation and activation (29, 62–64).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	For patients with ≤60 years, C-index for 5y-OS was 0.722, 0.585 and 0.724 for aaIPI, R-IPI and NCCN-IPI, respectively, and R-IPI was outperformed by NCCN-IPI but not by aaIPI (p=0.023 and p=0.077, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	All of the above-mentioned properties concern the use of monomeric metal complexes, i.e., containing a single metal per molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "of", "the"...
PMC10158546	ReN cells were treated with 1 μL of mouse PrP expressing lentiviral prep (LV-prep) for 72 hours, with or without TransDux enhancer, at which point the cells were treated with 0.5 μg/mL puromycin.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10840195	Researchers at the University of Leeds in the UK confirmed that increasing VDR levels in melanoma cells can reduce the activity of the Wnt/β-catenin pathway, slow the growth of melanoma cells and prevent tumour cell metastasis to the lung .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	MAPK3 is the top activated kinase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAPK3", "is", "the", "top", "activated", "kinase", "." ] } ]
PMC11607638	The effect of microinjected SK 1 and 2 on blood meal intake, as well as the possible reversal by SKR receptor antagonist were examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10158546	We noticed that ReN cells expressed predominantly faster migrating PrP species upon differentiation (Figure 3b), perhaps indicating that mono-glycosylated and non-glycosylated forms were primarily available for PrP replication.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	J. Senapati, H. Kantarjian, N. Short, M. Konopleva, F. Ravandi, N. Jain, P. A. Thompson, N. Pemmaraju, W. G. Wierda, G. Borthakur, T. M. Kadia, G. Garcia-Manero, M. Yilmaz, J. Thankachan, M. Zhao, C. Loiselle, M. T. Talley, M. I. Kwari, R. S. Garris, E. J. Jabbour Leukemia, MD Anderson Cancer Center, Houston, United St...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	By using a stochiometric mechanism for Ci/Gli activation through conformational change, Fu/Ulk3-mediated Hh signal transduction results in a linear increase of signal outputs that is proportional to signal inputs, allowing cells to be able to respond to a broad range of Hh morphogen inputs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median OS was not estimable and no significant benefit was seen for C+R over P+R, although the risk of death was reduced (HR 0.86 [95% CI 0.55, 1.32]) vs the August 2020 disclosure (HR 1.07 [0.63, 1.82]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8708099	In our experiments, incubation of Caco-2 with histamine resulted in a marked increase in secretion of all tested CKs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "experi...
PMC11155445	All acyl thiourea derivatives of naproxen (136a–g) exhibit prominent anti-inflammatory activity with percentage inhibition in between 47% to 54% at the fourth hour following injection of carrageenan.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median overall survival was 53.2 months (95% CI: 43.3-63.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "overall", "survival", "was", "53.2", "months", "(...
PMC11739504	a, b) During ciliogenesis, the basal expression level and subcellular localization of Kat2b in the cytosol, centrosome, and basal body gradually increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	The greater biological effects of asTORi relative to rapamycin have been linked to differential effects on the 4EBP-eIF4E axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "greater", "biological", "e...
PMC11423992	Relative luminescence units were quantified using the Bio-Glo luciferase assay reagent (cat. #	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "luminescence", "units", "were", "quantified", "using", "th...
PMC11538390	However, recently collected samples were genotyped on two versions of a custom designed Affymetrix array, referred to as FinnGen1 (657,675 markers) and FinnGen2 (664,510 markers), with 655,973 overlapping markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748618	This unique genetic architecture results in reduced LD and increased haplotype diversity within the population which can make identifying a causal signal challenging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC8526701	We also evaluated the role of kinases in the progression of GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "evaluated", "the", "role", "of", "kinases", "in", "the", "pr...
PMC11703896	These receptors are commonly overexpressed or mutated in various cancers, where they play key roles in promoting cell proliferation, survival, metastasis, and angiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median time to new anti-lymphoma therapy or crossover was not evaluable (ZO; NE) vs 12.1 mo (O; HR, 0.37 [95% CI, 0.23-0.60], p<0.0001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705630	All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Keimyung University, School of Medicine, Daegu, Korea (KM-2020-16R1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: By using murine AML cell lines lacking either STAT3α or STAT3β, we aim to elucidate the STAT3 isoform-specific impact on cellular processes shaping AML development and progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7685376	Volcano map showing the down-regulated, up-regulated and unchanged proteins after Huaier treatment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "map", "showing", "the", "down-regulated", ",", "up-regulate...
PMC10237474	Together, these results suggest that the complex expressed in Expi293F GnTI stable pools was less glycosylated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Together", ",", "these", "results", "suggest", ...
PMC9847912	Each point is the mean of four cultures that were maintained in parallel.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "point", "is", "the", "mean", "of", "four", "cultures", "that"...
PMC9429973	The HMA group had a numerically higher proportion of male patients (61.7 vs 55.5%), were younger (mean age, 67.5 vs 70.4 years), had lower comorbidity burden (Charlson Comorbidity Index [CCI] ≥3, 29.7 vs 34.5%), and were more likely to be commercially insured (46.1 vs 34.9%) than patients in the no HMA group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10734950	To investigate F8 ability to induce alteration in cell cycle profile, CCRF-CEM cells were plated in 24-well plates at a density of 100,000 cells per well, with each well containing1 ml of media .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543885	Aspirate the PLL solution, and rinse with 200 μL Milli-Q water for three times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aspirate", "the", "PLL", "solution", ",", "and", "rinse", ...
PMC9388315	One of that isoenzymes is LDHA, which can be increased in most cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "that", "isoenzymes", "is", "LDHA", ",", "which", ...
PMC10547921	ADCs have become one of the fastest-developing drug classes in oncology in recent years, because of their lower side effects, broader treatment applications, and higher therapeutic index.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	realMIND is actively recruiting.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "realMIND", "is", "actively", "recruiting", "." ] } ]
PMC11593713	Total antioxidant capacity (TAC) was measured using method by Erel .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "antioxidant", "capacity", "(", "TAC", ")", "was", "measured", "using", ...
PMC11412721	nd: not determined.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "nd", ":", "not", "determined", "." ] } ]
PMC11682172	Total numbers of proteins measured in the cancer cell lines prior to, and incubation with activated T lymphocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "numbers", "of", "protein...
PMC11437637	Add 500 µl diluent for blood cell analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Add", "500", "µl", "diluent", "for", "blood", "cell", "analysis", "." ] } ]
PMC9429973	Ninety-three% (182/195) of patients received a third dose of the vaccine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ninety-three%", "(", "182/195", ")", "of", "patients", "received", "a", ...
PMC11746948	Total RNA was extracted using the GeneJET RNA Purification Kit (Thermo Fisher Scientific) according to the manufacturer’s instructions, and first-strand cDNA synthesis was performed using the RevertAid First Strand cDNA Synthesis Kit (Thermo Fisher Scientific) following the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6114978	A deletion was noted in RD, however the cell line is polyploid, and two copies of LATS2 were still present.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "deletio...
PMC5833712	SIRT1 belongs to a family of seven class III histone deacetylases (HDACs) enzymes, which are highly conserved enzyme homologs of the yeast Sir2 protein, with nicotine adenine dinucleotide NAD+-dependent protein deacetylase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682224	Lesions can manifest as nodules, ulcers, or plaques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lesions", "can", "manifest", "as", "nodules", ",", "ulcers", ",", "or", "plaques", "." ...
PMC11237030	Cell membrane proteins were biotinylated with EZ-Link Sulfo-NHS-Biotin (Thermo Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "membrane", "proteins", "were", "biotinylated", "with", "EZ-Link", "Sulfo-NHS-B...
PMC9872547	Therefore, it can be concluded that nano-curcumin is safe for normal cells at the studied concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "can", "be", "conclu...
PMC11609529	On day 17, all mice were euthanized, and the peritoneal tumor nodules developed from each mouse were harvested, photographed, and weighed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11509224	Dendrillins B–D (85–87, Figure 9) were also produced by the D. antarctica sponge .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dendrillins", "B", "–", "D", "(", ...
PMC11401350	Here we used our mAITL preclinical model to validate the generation of anti-CD4 CAR T cells in vivo exclusively expressed by the CD8 T cells in the AITL tumor environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	However, these chemicals often target multiple regulators and pathways, resulting in off‐target effects. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "these", "chemicals", "often", "target"...
PMC8427838	Red arrows point to the apical membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "arrows", "point", "to", "the", "apical", "membrane", "." ] } ]
PMC10747160	Oddly, when the concentration of WT-Grft was increased to 47 nM and higher, the SARS-CoV-2 pseudovirus appeared to display greatly enhanced infectivity, reaching infectivity values that were 1 order of magnitude higher than samples without any Griffithsin present.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7342409	In our study, we found that the phosphorylation level of ERK was related to autophagy, and the autophagy level of the combination group decreased significantly after adding CQ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766350	Although expression of the anti-gfp shRNA was not sufficient to fully restore rAAV-TRAIL yields to the level of a non-TRAIL rAAV control, increasing the number of shRNA cassette repeats might offer further improvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	SCID mice were injected with VAL cells in the left flank and pair matched based on tumor volume after three days of tumor growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6163708	Since it has been reported that GANT61 may cause autophagy in some cells types , it can also be possible that in some cell lines, the elimination of cells could be brought about by autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Blocking was performed with 5% bovine serum albumin in TBST for 1 h before incubations with primary antibodies at 4 °C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	We also detected a total of 43 (4.6%) secondary malignancies, 28 (5.4%) in GCV and 15 (3.7%) in C (p=0.222).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11387401	Fold increase is calculated compared to the background of non-interacting RNAs (with average sequencing counts >500). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fold", "increase", "is", ...
PMC11301927	The F/B ratio was higher in the Latino group as compared to the non-Latino group (1.00 vs 0.92).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "F/B", "ratio", ...
PMC9429973	No AEs related to DISC-0974 were reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "AEs", "related", "to", "DISC-0974", "were", "reported", "." ] } ]
PMC3931643	Using m-GTP pull down assays, we observed that a 4 hour asTORi treatment with MLN028 or PP242 did not reduce the amount of eIF4G bound to eIF4E ( Fig. 3 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628309	An additional variable in culture conditions is the FBS concentration that is used in the cell culture medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "additional", "variable", "in", "...
PMC11725127	Taken together, these results suggest that USP2 may enhance the protein stability of KRAS.Figure 4USP2 regulates protein level and ubiquitination of KRAS. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10877303	On the contrary, ‘BIOVIA Discovery Studio’ explored the non-binding interaction between these three drug candidates and the 3C-like protease (3CL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10823017	PKC-ι and c-Myc association is also markedly reduced by the combination therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PKC-ι", "and", "c-Myc", "association", "is", "also", "markedly", "reduced", "by"...
PMC9368503	There is a lack of effective systemic therapies for these patients and therefore an urgent need to develop new approaches to tackle this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	No pleural effusions were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "pleural", "effusions", "were", "observed", "." ] } ]
PMC11594641	Secondly, the complete culture medium was ultracentrifuged at 100,000× g for 2.5 h at 4 °C to discard any remaining serum sEVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11628904	Here, we identify that keratinocyte behaviour promotes burn wound conversion following injury and is associated with wound infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "identify", ...
PMC11802855	Consequently, we proceeded with the validation of MMP13 and C-myc expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "we", "proceeded", "with", "the", "validation", "of", ...
PMC10988808	Therefore, a luciferase activity assay on the ITGA3 promoter confirmed that YAP can enhance the promoter activity of ITGA3 and that CCDC25 inhibits this effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9635307	Moreover, it has been revealed that CEACAM1 expressed in T cells located in the mucosa can regulate intestinal immune responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC7504302	A comprehensive genomic analysis has recently studied the differential gene expression profiles of 216 human primary MPM samples and their matched normal counterparts, one of the largest cohorts in recent years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	Significant differences between colony numbers were calculated by 1-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "differences", "between", "colony", "numbers", "were", "calculated", "by", "1-way", ...
PMC10671321	It also leads to an increase of the levels of AChR subunit mRNAs and the number of AChR clusters in iPSC-derived skeletal muscle cells from the patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	Cancer encompasses a variety of types depending on the site of occurrence, age of the patient, stage of the cancer, as well as metastatic status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11471176	The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11365427	n = 5. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ".", "(" ] } ]
PMC9429973	Next, we used the topologically associating domains (TAD) resulting from Hi-C data and RNAseq data to identify the potential target genes of the 197 de novo DARs in subset #8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	To quantify lung metastases, the number of tumor nodules in each lung was recorded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "quantify", "lung", "metastases", ",", "the", "number"...

PMC11721096

1 and Fr.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "1", "and", "Fr", "." ] } ]

PMC11604768

TF binding motifs included in the initial screening library were selected from a published set of position weight matrices (PWMs) derived for 411 human and mouse TFs using HT-SELEX.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11424574

Wu et al. found that COX2 knockdown in OS-732 cells significantly inhibited uPA expression and their invasiveness .

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PMC11650848

Spliced junctions represented as red bars; arcs display the number of reads split across the junction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spliced", "junctions", "represented", "as", "red"...

PMC9596868

Images for PA-1 were acquired on a Vert.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "for", "PA-1", "were", "acquired", "on", "a", "Vert", "." ] } ]

PMC11696576

AX048 (7, Fig. 1) exhibited an antihyperalgesic effect in rats, blocking prostaglandin E2 (PGE2) release evoked by substance P. Among a series of 1-heteroarylpropan-2-ones, compound 8 (Fig. 1) was found to be a highly potent inhibitor of cPLA2α.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10887351

The authors observed that apigenin inhibited the antioxidant protein expression, such as superoxide dismutase-2, catalase, and thioredoxin, but it increased the UCP2 and GSH levels that, inversely, were strongly inhibited by β3-ARs antagonism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9874064

Unfortunately, the DNA repair machinary is powerful in cancer cells, resulting in resistance to platinum drugs .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "the", "DNA", "re...

PMC11708541

The rotarod test and open field test behaviour index verified that 4-AP reduced the motor impairments brought on by MPTP 69.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rotarod", ...

PMC11766309

YKT6 expression in the tumor tissue compared with corresponding paratumor tissue among the 33 tumors; (B) Mean expression of YKT6 in the 33 different tumor types based on the TCGA database; (C) Mean expression levels of YKT6 in different organs based on the GTEx database; (D) Mean expression levels in the diverse cance...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10178190

Thus, in this experimental protocol, ERK1/2 phosphorylation does not correlate to platinum chemoresistance.

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PMC3019555

More specifically, we found that 9% of total HIF-1α mRNA localized to P-bodies in control cells, whereas 64% and 70% of HIF-1α mRNA were found in P-bodies after treatment with 2ME2 or TX, respectively (Fig. 5 C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11344246

An alternate approach to identify protein drug targets is to map the protein-protein interactions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "alternate", "approach", "to", "identify", "protein", "drug", ...

PMC11626627

A recent study explored the molecular mechanisms by which TWIST1 suppresses E-cadherin expression to promote EMT, cancer cell migration, invasion, and metastasis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC8068766

GSEA results have revealed that the relatively upregulated genes in HepG2-2.2.15 cells were found to be more related to DNA-repair, G2M checkpoint, oxidation reduction, and MTORC1 signaling pathways, which might be key pathways for the acquired tolerance gained by HepG2-2.2.15 cells to Se-deficiency-dependent oxidative...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...

PMC11727145

Our results indicated that cholera toxin and hydrocortisone could be omitted without affecting medium functionality on the DED constructs for cell seeding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "resul...

PMC3931643

We chose these cell lines from a larger panel of DLBCLs because they express BAX, BAK and BIM and are therefore have an intact apoptotic machinery.

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PMC11306331

Thus, there is still an unmet need for tools to precisely control biomolecular condensate dissolution in the complex environment of the cell.

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PMC11495567

(1:1000), KRAS (Cat. #

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "(", "1:1000", ")", ",", "KRAS", "(", "Cat", ".", "#" ] } ]

PMC11546117

Accessed 9 March 2021).

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PMC9429973

In Japan, immediate post-cBTKi regimens were nearly exclusively chemotherapy based (n=92, 89.3%), and only 11 (10.7%) patients were retreated with cBTKi-containing regimens.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721587

In response to Hh, both Gli2 and Sufu accumulate at ciliary tip and hindering Gli2 ciliary localization blocks its phosphorylation and activation (29, 62–64).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

For patients with ≤60 years, C-index for 5y-OS was 0.722, 0.585 and 0.724 for aaIPI, R-IPI and NCCN-IPI, respectively, and R-IPI was outperformed by NCCN-IPI but not by aaIPI (p=0.023 and p=0.077, respectively).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11052306

All of the above-mentioned properties concern the use of monomeric metal complexes, i.e., containing a single metal per molecule.

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PMC10158546

ReN cells were treated with 1 μL of mouse PrP expressing lentiviral prep (LV-prep) for 72 hours, with or without TransDux enhancer, at which point the cells were treated with 0.5 μg/mL puromycin.

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PMC10840195

Researchers at the University of Leeds in the UK confirmed that increasing VDR levels in melanoma cells can reduce the activity of the Wnt/β-catenin pathway, slow the growth of melanoma cells and prevent tumour cell metastasis to the lung .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6461034

MAPK3 is the top activated kinase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAPK3", "is", "the", "top", "activated", "kinase", "." ] } ]

PMC11607638

The effect of microinjected SK 1 and 2 on blood meal intake, as well as the possible reversal by SKR receptor antagonist were examined.

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PMC10158546

We noticed that ReN cells expressed predominantly faster migrating PrP species upon differentiation (Figure 3b), perhaps indicating that mono-glycosylated and non-glycosylated forms were primarily available for PrP replication.

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PMC9429973

J. Senapati, H. Kantarjian, N. Short, M. Konopleva, F. Ravandi, N. Jain, P. A. Thompson, N. Pemmaraju, W. G. Wierda, G. Borthakur, T. M. Kadia, G. Garcia-Manero, M. Yilmaz, J. Thankachan, M. Zhao, C. Loiselle, M. T. Talley, M. I. Kwari, R. S. Garris, E. J. Jabbour Leukemia, MD Anderson Cancer Center, Houston, United St...

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PMC11721587

By using a stochiometric mechanism for Ci/Gli activation through conformational change, Fu/Ulk3-mediated Hh signal transduction results in a linear increase of signal outputs that is proportional to signal inputs, allowing cells to be able to respond to a broad range of Hh morphogen inputs.

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PMC9429973

Median OS was not estimable and no significant benefit was seen for C+R over P+R, although the risk of death was reduced (HR 0.86 [95% CI 0.55, 1.32]) vs the August 2020 disclosure (HR 1.07 [0.63, 1.82]).

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PMC8708099

In our experiments, incubation of Caco-2 with histamine resulted in a marked increase in secretion of all tested CKs.

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PMC11155445

All acyl thiourea derivatives of naproxen (136a–g) exhibit prominent anti-inflammatory activity with percentage inhibition in between 47% to 54% at the fourth hour following injection of carrageenan.

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PMC9429973

Median overall survival was 53.2 months (95% CI: 43.3-63.0).

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PMC11739504

a, b) During ciliogenesis, the basal expression level and subcellular localization of Kat2b in the cytosol, centrosome, and basal body gradually increased.

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PMC3931643

The greater biological effects of asTORi relative to rapamycin have been linked to differential effects on the 4EBP-eIF4E axis.

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PMC11423992

Relative luminescence units were quantified using the Bio-Glo luciferase assay reagent (cat. #

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PMC11538390

However, recently collected samples were genotyped on two versions of a custom designed Affymetrix array, referred to as FinnGen1 (657,675 markers) and FinnGen2 (664,510 markers), with 655,973 overlapping markers.

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PMC11748618

This unique genetic architecture results in reduced LD and increased haplotype diversity within the population which can make identifying a causal signal challenging.

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PMC8526701

We also evaluated the role of kinases in the progression of GIST.

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PMC11703896

These receptors are commonly overexpressed or mutated in various cancers, where they play key roles in promoting cell proliferation, survival, metastasis, and angiogenesis.

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PMC9429973

Median time to new anti-lymphoma therapy or crossover was not evaluable (ZO; NE) vs 12.1 mo (O; HR, 0.37 [95% CI, 0.23-0.60], p<0.0001).

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PMC11705630

All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Keimyung University, School of Medicine, Daegu, Korea (KM-2020-16R1).

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PMC9429973

Methods: By using murine AML cell lines lacking either STAT3α or STAT3β, we aim to elucidate the STAT3 isoform-specific impact on cellular processes shaping AML development and progression.

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PMC7685376

Volcano map showing the down-regulated, up-regulated and unchanged proteins after Huaier treatment. (

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PMC10237474

Together, these results suggest that the complex expressed in Expi293F GnTI stable pools was less glycosylated.

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PMC9847912

Each point is the mean of four cultures that were maintained in parallel.

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PMC9429973

The HMA group had a numerically higher proportion of male patients (61.7 vs 55.5%), were younger (mean age, 67.5 vs 70.4 years), had lower comorbidity burden (Charlson Comorbidity Index [CCI] ≥3, 29.7 vs 34.5%), and were more likely to be commercially insured (46.1 vs 34.9%) than patients in the no HMA group.

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PMC10734950

To investigate F8 ability to induce alteration in cell cycle profile, CCRF-CEM cells were plated in 24-well plates at a density of 100,000 cells per well, with each well containing1 ml of media .

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PMC11543885

Aspirate the PLL solution, and rinse with 200 μL Milli-Q water for three times.

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PMC9388315

One of that isoenzymes is LDHA, which can be increased in most cancers .

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PMC10547921

ADCs have become one of the fastest-developing drug classes in oncology in recent years, because of their lower side effects, broader treatment applications, and higher therapeutic index.

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PMC9429973

realMIND is actively recruiting.

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PMC11593713

Total antioxidant capacity (TAC) was measured using method by Erel .

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PMC11412721

nd: not determined.

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PMC11682172

Total numbers of proteins measured in the cancer cell lines prior to, and incubation with activated T lymphocytes.

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PMC11437637

Add 500 µl diluent for blood cell analysis.

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PMC9429973

Ninety-three% (182/195) of patients received a third dose of the vaccine.

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PMC11746948

Total RNA was extracted using the GeneJET RNA Purification Kit (Thermo Fisher Scientific) according to the manufacturer’s instructions, and first-strand cDNA synthesis was performed using the RevertAid First Strand cDNA Synthesis Kit (Thermo Fisher Scientific) following the manufacturer’s protocol.

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PMC6114978

A deletion was noted in RD, however the cell line is polyploid, and two copies of LATS2 were still present.

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PMC5833712

SIRT1 belongs to a family of seven class III histone deacetylases (HDACs) enzymes, which are highly conserved enzyme homologs of the yeast Sir2 protein, with nicotine adenine dinucleotide NAD+-dependent protein deacetylase activity.

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PMC11682224

Lesions can manifest as nodules, ulcers, or plaques.

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PMC11237030

Cell membrane proteins were biotinylated with EZ-Link Sulfo-NHS-Biotin (Thermo Scientific).

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PMC9872547

Therefore, it can be concluded that nano-curcumin is safe for normal cells at the studied concentration.

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PMC11609529

On day 17, all mice were euthanized, and the peritoneal tumor nodules developed from each mouse were harvested, photographed, and weighed.

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PMC11509224

Dendrillins B–D (85–87, Figure 9) were also produced by the D. antarctica sponge .

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PMC11401350

Here we used our mAITL preclinical model to validate the generation of anti-CD4 CAR T cells in vivo exclusively expressed by the CD8 T cells in the AITL tumor environment.

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PMC11615828

However, these chemicals often target multiple regulators and pathways, resulting in off‐target effects. ,

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PMC8427838

Red arrows point to the apical membrane.

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PMC10747160

Oddly, when the concentration of WT-Grft was increased to 47 nM and higher, the SARS-CoV-2 pseudovirus appeared to display greatly enhanced infectivity, reaching infectivity values that were 1 order of magnitude higher than samples without any Griffithsin present.

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PMC7342409

In our study, we found that the phosphorylation level of ERK was related to autophagy, and the autophagy level of the combination group decreased significantly after adding CQ.

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PMC11766350

Although expression of the anti-gfp shRNA was not sufficient to fully restore rAAV-TRAIL yields to the level of a non-TRAIL rAAV control, increasing the number of shRNA cassette repeats might offer further improvement.

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PMC11225860

SCID mice were injected with VAL cells in the left flank and pair matched based on tumor volume after three days of tumor growth.

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PMC6163708

Since it has been reported that GANT61 may cause autophagy in some cells types , it can also be possible that in some cell lines, the elimination of cells could be brought about by autophagy.

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PMC11754432

Blocking was performed with 5% bovine serum albumin in TBST for 1 h before incubations with primary antibodies at 4 °C overnight.

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PMC9429973

We also detected a total of 43 (4.6%) secondary malignancies, 28 (5.4%) in GCV and 15 (3.7%) in C (p=0.222).

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PMC11387401

Fold increase is calculated compared to the background of non-interacting RNAs (with average sequencing counts >500). (

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PMC11301927

The F/B ratio was higher in the Latino group as compared to the non-Latino group (1.00 vs 0.92).

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PMC9429973

No AEs related to DISC-0974 were reported.

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PMC3931643

Using m-GTP pull down assays, we observed that a 4 hour asTORi treatment with MLN028 or PP242 did not reduce the amount of eIF4G bound to eIF4E ( Fig. 3 ).

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PMC11628309

An additional variable in culture conditions is the FBS concentration that is used in the cell culture medium.

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PMC11725127

Taken together, these results suggest that USP2 may enhance the protein stability of KRAS.Figure 4USP2 regulates protein level and ubiquitination of KRAS. (

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PMC10877303

On the contrary, ‘BIOVIA Discovery Studio’ explored the non-binding interaction between these three drug candidates and the 3C-like protease (3CL).

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PMC10823017

PKC-ι and c-Myc association is also markedly reduced by the combination therapy.

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PMC9368503

There is a lack of effective systemic therapies for these patients and therefore an urgent need to develop new approaches to tackle this disease.

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PMC9429973

No pleural effusions were observed.

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PMC11594641

Secondly, the complete culture medium was ultracentrifuged at 100,000× g for 2.5 h at 4 °C to discard any remaining serum sEVs.

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PMC11628904

Here, we identify that keratinocyte behaviour promotes burn wound conversion following injury and is associated with wound infection.

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PMC11802855

Consequently, we proceeded with the validation of MMP13 and C-myc expression levels.

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PMC10988808

Therefore, a luciferase activity assay on the ITGA3 promoter confirmed that YAP can enhance the promoter activity of ITGA3 and that CCDC25 inhibits this effect.

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PMC9635307

Moreover, it has been revealed that CEACAM1 expressed in T cells located in the mucosa can regulate intestinal immune responses .

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PMC7504302

A comprehensive genomic analysis has recently studied the differential gene expression profiles of 216 human primary MPM samples and their matched normal counterparts, one of the largest cohorts in recent years.

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PMC11740508

Significant differences between colony numbers were calculated by 1-way ANOVA.

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PMC10671321

It also leads to an increase of the levels of AChR subunit mRNAs and the number of AChR clusters in iPSC-derived skeletal muscle cells from the patient.

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PMC11684297

Cancer encompasses a variety of types depending on the site of occurrence, age of the patient, stage of the cancer, as well as metastatic status.

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PMC11471176

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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PMC11365427

n = 5. (

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PMC9429973

Next, we used the topologically associating domains (TAD) resulting from Hi-C data and RNAseq data to identify the potential target genes of the 197 de novo DARs in subset #8.

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PMC11783017

To quantify lung metastases, the number of tumor nodules in each lung was recorded.

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