OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9503669	While this study did not include follow-up data for inhibition of Nef function, it illustrates a more direct approach to identify small molecule Nef binders that may represent leads for further development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: The ED rate in our series is higher than those described in the literature (21% vs 5-10%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	We plotted overall survival (OS) curves and found significantly higher OS rates among patients with low circUSP10 expression than those with high circUSP10 levels (Fig. 1G).Table 1Relationship of circUSP10 expression with clinicopathological features in liver cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11337594	Following a 48-hour treatment with 2.0 µg/ml TER, the viability of A375 and M14 cells was reduced to nearly 50%, while HepG2 cells exhibited an inhibition of approximately 25% (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine"...
PMC11742431	A threshold of p < 0.05 was applied to define statistical significance, denoted as follows: * for p < 0.05, for p < 0.01, * for p < 0.001, and ns indicate not significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11075223	However, there are obvious differences in appearances among the official Cimicifuga.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "obvious", "differences", "in", "appearances", "a...
PMC9046263	We analyzed differences in mean expression of overall counts among our cell lines of interest using one-way ANOVA under multiple comparison correction conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11473843	Graphical data are mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphical", "data", "are", "mean", "±", "SD", "." ] } ]
PMC11317131	The indel frequency was determined by dividing total discarded reads (Reference + HDR) by ‘Reads_aligned_all_amplicons’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "indel", "frequency", "was"...
PMC11637284	The purified p166 C-tail was directly labelled with a fluorochrome and incubated with the peptide microarray immobilized on a glass surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "purified", ...
PMC11756514	This suggests that the WTA on S. aureus indeed is an authentic ligand for MBL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "the", "WTA", "on", "S.", ...
PMC11785489	Under the null, we would expect 25 (of 115) transcriptionally concordant TCR-twin pairs (see STAR Methods).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "the", "n...
PMC9429973	Subsequently ABSOLUTE software is used to calculate the cancer cells fraction of each variant and CNVs in order to follow the clonal evolution of sequential samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6222726	Furthermore, yatein (17) was demonstrated to be a potent CYP3A4 inhibitor and this study is of particular importance as 17 and other methylenedioxyphenol compounds were found to induce herb-drug interactions in clinical situations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	Experiments were designed to determine the specificity, affinity, and cell killing efficacy of LMTK3BP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "designed", "to", "determine", "...
PMC11670954	The average relative immunofluorescence intensities of RhoA, ROCK2, and MLCK in the BL + Y-27632 group were lower than those in the LPS + Y-27632 group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10957991	Phalloidin visualizes actin cytoskeleton (green) and DAPI nuclei (blue).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phalloidin", "visualizes", "actin", "cytoskeleton", "(", "green", ")", "and...
PMC11706776	The expression of KCNN1 was measured by RT-qPCR after 72 h or 7 days of doxycycline treatment (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", ...
PMC11562028	Mouse blood was collected for routine blood and biochemical index analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "blood", "was", "collected", "for", "routine", "blood", "and", "biochemical", ...
PMC11366496	ChIP experiments were conducted to investigate the role of STAT3 in gene regulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChIP", "experiments", "were", "conducted", "to", "investigate", "the", "rol...
PMC11412721	Because lymphoma is a common neoplasm in C57Bl/6J WT mice (Brayton et al., 2012) and our mouse cohorts resulted from >10 generations of backcrosses with C57Bl/6J mice, we searched for evidence of lymphoma in the lymph nodes and spleen, by macroscopic examination at autopsy and histological analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11583010	A standard panel of tissue and organ samples were collected from all animals and processed for histopathologic investigations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "standard", "panel", "of", "tissue...
PMC4270159	Media only [additional].Vehicle control.0.001 µM–10 µM erlotinib + no ligand.0.001 µM–10 µM erlotinib + 50 ng/ml HGF.0.001 µM–10 µM erlotinib + 50 ng/ml HGF + 0.5 µM crizotinib.0.5 µM crizotinib + no ligand [additional].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	In vitro experiments showed that the survival, migration, and invasion of the cSCC cell lines HSC-1 and A431 were significantly inhibited upon METTL1 inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC9429973	Aims: The goal of my project is to test the antileukemic potential of iD in cellular and animal models of DUX4-r leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ...
PMC9436459	Subsequently, more than 20 MDAAs were reported to have significant inhibitory activity against tyrosinase (Table 8) .Table 8Inhibitory activities of MDAAs against tyrosinaseCompd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Aims: Here, we present the primary analysis from GEMSTONE-201, the largest registrational study reported to date to evaluate an anti-PD-L1 mAb in R/R ENKTL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499955	The technology uses MS-tag isotopologues and the sydnonimine-cyclooctyne click-and-release bioorthogonal reaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "technology", "uses", "MS-tag", "isotopologues", "and", "the", "sydnonimine-cyclooctyne", ...
PMC6379402	However, on our data, SNF returns empty integrated networks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "on", "our", "data", ",", "SNF", "returns", "empty", "integrated", ...
PMC10748106	Geniposidic acid has an acid at C4, just like 10-O-(E)-p-coumaroylgeniposidic acid (this last one additionally presents a p-coumaroyl group at C10), contrary to Geniposide, which presents an ester at C4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9596868	Combination treatment significantly reduced the colony formation ability of PA-1, A2780 and HCT116 cells as compared to individual treatments thereby confirming that the combinatorial treatment of quercetin and MST-312 effectively exacerbates cell death in these cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11597167	Similarly, EGCG also has anti-inflammatory and neuroprotective properties, and it has been proven that the production of TNF-α-induced monocytes is inhibited after EGCG treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Many studies involved lymphopenia as prognostic factor for unfavourable evolution of COVID-19 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "studies", "involved", "lymphopenia", "as", "prognostic", "factor", ...
PMC10728200	To clarify the specific molecular mechanism of IM-induced ferroptosis, we examined the effects of different IM concentrations and treatment time on the expression of SLC7A11 and GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11521786	While this polyclonality was expected given that the whole extracellular domain of HER3 was used as the antigen, this result not only explains PAbs’ potential to downregulate the target receptor but also suggests that effector functions beyond target degradation could be elicited by these PAbs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	But there was no significant difference in terms of 1-year OS ([79.9 (60.5-90.4)%] vs [84.0 (61.2-94.0)%], P = 0.4411) or RR ([13.6 (2.73-33.2)%] vs [15.2 (4.40-32.1)%], P = 0.7416).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10565698	Sixty-seven paired LC and para-cancerous tissue specimens were collected between April 2019 and April 2020 from the Affiliated Hospital of Nantong University and the Nantong Third People's Hospital.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	Model performance for each modeling step from the literature-derived starting model to the final model: (TOP) goodness of fit as weighted sum squared residuals divided by number of free parameters and (BOTTOM) consistency check step as percentage of error reduction compared to unperturbed control as null model (see S1 ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	After washing in PBS, cells were fixed with 4% paraformaldehyde and permeabilized with PBS-0.1% Triton-X (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", ...
PMC11423992	Therefore, subclones with low levels of CD20 expression should also be considered viable targets for TFAB002s.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "subclones", "with", "low", ...
PMC11638288	Alon et al.’s study demonstrates that NKp46 can recognize the heparan sulfate portion of heparan sulfate proteoglycans (HSPGs) on cervical adenocarcinoma tumor cells and melanoma cells, thereby enabling NK cells to lyse tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756907	Graphs A, B, C, and D (Figure 4) show the cytotoxicity of the graphene-based compounds: GO, GO-2ME, RrGO, and RrGO-2ME in DMSO solvent against 143B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	In this state, the solid target was irradiated with a laser beam (λ = 1064 nm; T = 4–200 ns; f = 20 kHz; P = 20 W; Ep = 1 mJ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Maximum expansion was reached at a median of 14.2 d by qPCR (13.9 d by flow cytometry).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Maximum", "expansion", "was", "re...
PMC7887261	Whether and how the c.*28delT affects POMC expression and their putative role to LC risk merit further mechanistic investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whether", "and", "how", "the", ...
PMC11779993	The isolates were then adjusted in Mueller Hinton broth (MHB) using a 0.5 McFarland standard for a bacterial total concentration of 1.5 × 10 CFU/mL. Antibacterial activities of SPEE were investigated using the broth microdilution method, which was used to explore the minimum inhibitory concentration (MIC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	Subsequent interaction between SUMO and SUMO-interacting motif drives Fu/Ulk3 self-assembly to form biomolecular condensates that recruit Ci-Sufu and Gli-Sufu in the cytoplasm and primary cilium, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711347	Chemotherapy, including the use of cisplatin, constitutes a fundamental component of cancer treatments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemotherapy", ",", "including", "the", "use", "of", "cispl...
PMC11599565	Clusters of EpCAM negative cells with concurrent stemness and neuronal signature are observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clusters", "of", "EpCAM", "negative", "cells", "with", "concurrent", "stemn...
PMC11530949	The existence and interactions of the copper element are linked to the formation of many peaks in the 400–700 cm-1 range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "existence", ...
PMC9429973	Key inclusion criteria were a diagnosis of MDS or CMML by WHO 2016, age ≥ 18 yrs, int-2 or high risk by IPSS, and bone marrow (BM) blasts of 5-19%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	Following the final recording, the mice had been euthanized,, their tumors removed and retained for further assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "final", ...
PMC5673060	In both sets of experiments, analysis of the distribution of phosphorylated residues shows the expected classical distribution of pSer:pThr:pTyr ratios (~ 90:10:1) as previously reported (Fig. S1A) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6889484	Primers CMVfor (5′-CAGAGCTCGTTTAGTGAACC-3′) and A3GendREV (5′-GATTCTGGAGAATGGCCCGC-3′) flank A3G(DK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primers", "CMVfor", "(", "5′-CAGAGCTCGTTTAGTGAACC-3′", ")", "and", "A3GendREV", ...
PMC11750161	Dose-response curves were generated for experiments performed in duplicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dose-response", "curves", "were", "generated", "for", "experiments", "performed", "in", "duplicates", "." ...
PMC9111184	In addition, PC2 loadings plot showed positive loadings at 1637 and 1683 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "PC2", "loadings", "plot", "showed", "posi...
PMC10698968	In addition to or before surgery, a chemotherapeutic treatment based on the alone or combined administration of doxorubicin and ifosfamide is mainly used as a palliative intervention due to the lack of consistent data obtained by clinical studies .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	AZA treatment can improve PB counts and delay progression to Akute Myeloid Leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AZA", "treatment", "can", "improve", "PB", "counts", "and", "delay", ...
PMC6461034	Fourth, another substrate‐centric analysis is included to complement the previous step.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fourth", ",", "another", "substrate‐centric", "analysis", "is", "included", "to", ...
PMC11371747	DHFR in humans has a markedly lower capacity (50-fold) to convert folic acid to DHF and THF then in widely used animal model systems such as the mouse (Bailey and Ayling, 2009).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Statistical analysis was performed by the two-way ANOVA method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "by", "the", "two-way", "ANOVA", "method", "." ] } ]
PMC3164356	However, CHO ST6Gal genes are not expressed, so CHO glycans primarily have α(2,3) linkages. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "CHO", "ST6Gal", "genes...
PMC11489351	We similarly used MetaCore pathway analysis software (Clarivate Analytics, https://portal.genego.com) to identify the cellular pathways with a high incidence of genes differentially regulated by pHi (see Methods, Table S5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679326	Also, as a therapeutic agent, APL was used to target hepatocellular carcinoma Hep3B, Huh7, and PLC/PRF/5 cells and breast cancer MCF-7 and MDA-MB-231 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-...
PMC11190238	Currently, we discussed the EMT spectrum in the context of transcriptional signature, there are other functional subtypes of the spectrum, including the ameboid state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3122064	Transfection with the scrambled siRNA had no effect on p53 levels or Nutlin-3-induced apoptosis, further demonstrating the wild-type p53-dependent effect of Nutlin-3 in TC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9351137	C Examples of IFM staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "Examples", "of", "IFM", "staining", "." ] } ]
PMC9429973	J. DiRaimo, C. Kruse, A. Kruse, M. Lambert, J. B. Bussel Platelet Disorder Support Association, Cleveland; Tulane University School of Medicine, New Orleans; Hematology, Children’s Hospital of Philadelphia, Philadelphia; Pediatric Hematology/Oncology, New York Presbyterian Hospital - Weill Cornell Medicine, New York, U...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	In the following months the patient presented vertebral metastases (see MRI Fig. 1A bottom right) and died a few months later.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC10671321	Samples (3–10 μL) were added to 200 µL of Ellman assay medium, and the reaction was monitored at 405 nm with a Byonoy Absorbance 96 (byoabs00835).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6468656	Acylated ghrelin (n-octanoyl) was prepared in ddH2O.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acylated", "ghrelin", "(", "n-octanoyl", ")", "was", "prepared", "in", "ddH2O", "." ] } ]
PMC9429973	Summary/Conclusion: Our study has shown that horizontal transmission of microbiota/pathogens to immunologically naïve adult mice leads to a reduction in HSC function similar to that shown by other groups with more severe infection models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9046263	Human endogenous retroviruses (HERV) are ancestral remnants of previous germline retroviral infections and account for 8% of the human genome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human",...
PMC9872547	RNA was reverse transcribed using a cDNA synthesis kit (Favorgen Biotech Company, Taiwan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "reverse", "transcribed", "using", "a", ...
PMC11799978	CAFs were then treated with various concentrations of NaHCO3 (0, 40, 80, 160, and 320 μg/mL) for a further 24 h. (B) Ratio of cell length to width in normal fibroblasts compared to CAFs treated with or without NaHCO3; and (C) phenotypic markers of fibroblasts assessed by flow cytometry. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11451940	Cells were seeded in a 24-well cell culture plate at 5 × 10 cells per well and allowed to grow for 24 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells",...
PMC11734514	The ability of A549 cells to cover scratches after treatment with C. aerizusa extract for 24 hours decreased over time (Figure 4).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "token...
PMC7351993	Since the linewidth of each wavelength channel is <10 cm and the bandwidth of the SRS microscope is about 300 cm, the number of colors can, in principle, be boosted to ~30, assuming that there is no spectral overlap between the consecutive channels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	Our experiments show that both free sorafenib and the SeSo nanocomplex did not cause cell death in cortical astrocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "experiments", "show", "tha...
PMC6799808	A diagram showing that GLPT inhibits mTORC1/2-mediated signaling pathways, thereby inhibiting cell proliferation and inducing cell death in tumor cells ReishiMax GLp, a standardized G. lucidum extract containing 13.5% polysaccharides and 6% triterpenes here termed GLPT, was purchased from Pharmanex (Provo, UT, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	Combining emerging knowledge regarding SMARCB1 with nanotechnology, which enables brain tumor-targeted gene delivery, we assessed the potential of SMARCB1 restoration in ATRT using our nanomedicine (termed scL-SMARCB1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11443022	In peripheral blood lymphocytes, 45,X was observed in 5 out of 20 cells, while 46,XY was detected in 15 out of 20 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11012012	Using tumor tissue microarrays, Roncador et al. (2022) analyzed the expression of SLAMF3/CD229 in 205 patients with nine different subtypes of B-CLPD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Of them, we found that omipalisib had more significant effect to inhibit “Oxidative phosphorylation” (NES: -2.01) than gedatolisib did (NES: -1.40), especially mitochondrial biogenesis and amino acid metabolism-related pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Antifolate sensitivity was determined in four selected NSCLC and MPM cell lines (Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antifolate", "sensitivity", "was", "determined", "in", "four", ...
PMC10772747	Flow cytometry was used to analyze cell cycle distribution after treatment with specific compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "was", "used", "to", "analyze", "cell", "cyc...
PMC10713411	The mRNA expression of KIRC and KIRP was normalized and transformed into the form of Log2 (TPM+1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mRNA", "expression", "of",...
PMC11754784	n > 30 from different cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", ">", "30", "from", "different", "cells", ")", "." ] } ]
PMC11502962	Seven cell types were identified in the single-cell analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seven", "cell", "types", "were", "identified", "in", "the", "single-cell", "analysis", "." ] } ]
PMC9429973	but markedly longer (median 116 months vs not reached) in patients with mutated IGHV without del 11q (HR 0.90; p=n.s.;	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11803149	A-F) n = 3 per group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-F", ")", "n", "=", "3", "per", "group", "." ] } ]
PMC11279397	Given this, it is crucial to further research and develop Perilla frutescens and its primary constituents to enhance its antiviral capabilities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "thi...
PMC11727062	Gambogic acid has been reported to reduce the viability of A375 cells, induce apoptosis, attenuate cell migration and invasion, and increase the sensitivity of drug-resistant cells to therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10854447	The epidermal growth factor receptor (EGFR) is a type of membrane receptor tyrosine kinase that is overexpressed in various tumours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "epide...
PMC10094712	Knockdown of the SELENOM gene in rats resulted in an increase in the activity of glutathione peroxidases and thioredoxin reductases in the brain, liver, lungs, and, to a lesser extent, in the kidneys and heart.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5811757	Target amplification efficiency was equal to that of the reference genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Target", "amplification", "efficiency", "was", "equal", "to", "that", "of", "the", "r...
PMC10858941	The left side corresponds to the centre of the chip (“Core”), where there is central hypoxia, while the right side corresponds to the region in contact with the side channels (“Lateral channel”). ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	Dominant clones were defined as clone size >= 50 based on 10X VDJ library readout (which counted all cells in the pre-filtered dataset).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11745823	In some malignant tumours such as lung adenocarcinoma, RIT1 mutations appear to be mutually exclusive with mutations in currently known driver genes such as KRAS and EGFR, which suggests that RIT1 may be an independent oncogenic factor in some tumours .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Muscle strength and SMI were significantly lower in patients with sarcopenia (p: 0.035; p: 0.01, respectively) (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9503669

While this study did not include follow-up data for inhibition of Nef function, it illustrates a more direct approach to identify small molecule Nef binders that may represent leads for further development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: The ED rate in our series is higher than those described in the literature (21% vs 5-10%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10565698

We plotted overall survival (OS) curves and found significantly higher OS rates among patients with low circUSP10 expression than those with high circUSP10 levels (Fig. 1G).Table 1Relationship of circUSP10 expression with clinicopathological features in liver cancer patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11337594

Following a 48-hour treatment with 2.0 µg/ml TER, the viability of A375 and M14 cells was reduced to nearly 50%, while HepG2 cells exhibited an inhibition of approximately 25% (Fig. 1A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine"...

PMC11742431

A threshold of p < 0.05 was applied to define statistical significance, denoted as follows: * for p < 0.05, ** for p < 0.01, *** for p < 0.001, and ns indicate not significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11075223

However, there are obvious differences in appearances among the official Cimicifuga.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "obvious", "differences", "in", "appearances", "a...

PMC9046263

We analyzed differences in mean expression of overall counts among our cell lines of interest using one-way ANOVA under multiple comparison correction conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...

PMC11473843

Graphical data are mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphical", "data", "are", "mean", "±", "SD", "." ] } ]

PMC11317131

The indel frequency was determined by dividing total discarded reads (Reference + HDR) by ‘Reads_aligned_all_amplicons’.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "indel", "frequency", "was"...

PMC11637284

The purified p166 C-tail was directly labelled with a fluorochrome and incubated with the peptide microarray immobilized on a glass surface.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "purified", ...

PMC11756514

This suggests that the WTA on S. aureus indeed is an authentic ligand for MBL.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "the", "WTA", "on", "S.", ...

PMC11785489

Under the null, we would expect 25 (of 115) transcriptionally concordant TCR-twin pairs (see STAR Methods).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "the", "n...

PMC9429973

Subsequently ABSOLUTE software is used to calculate the cancer cells fraction of each variant and CNVs in order to follow the clonal evolution of sequential samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC6222726

Furthermore, yatein (17) was demonstrated to be a potent CYP3A4 inhibitor and this study is of particular importance as 17 and other methylenedioxyphenol compounds were found to induce herb-drug interactions in clinical situations .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11406030

Experiments were designed to determine the specificity, affinity, and cell killing efficacy of LMTK3BP.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "designed", "to", "determine", "...

PMC11670954

The average relative immunofluorescence intensities of RhoA, ROCK2, and MLCK in the BL + Y-27632 group were lower than those in the LPS + Y-27632 group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10957991

Phalloidin visualizes actin cytoskeleton (green) and DAPI nuclei (blue).

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PMC11706776

The expression of KCNN1 was measured by RT-qPCR after 72 h or 7 days of doxycycline treatment (Sigma-Aldrich).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", ...

PMC11562028

Mouse blood was collected for routine blood and biochemical index analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "blood", "was", "collected", "for", "routine", "blood", "and", "biochemical", ...

PMC11366496

ChIP experiments were conducted to investigate the role of STAT3 in gene regulation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ChIP", "experiments", "were", "conducted", "to", "investigate", "the", "rol...

PMC11412721

Because lymphoma is a common neoplasm in C57Bl/6J WT mice (Brayton et al., 2012) and our mouse cohorts resulted from >10 generations of backcrosses with C57Bl/6J mice, we searched for evidence of lymphoma in the lymph nodes and spleen, by macroscopic examination at autopsy and histological analyses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11583010

A standard panel of tissue and organ samples were collected from all animals and processed for histopathologic investigations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "standard", "panel", "of", "tissue...

PMC4270159

Media only [additional].Vehicle control.0.001 µM–10 µM erlotinib + no ligand.0.001 µM–10 µM erlotinib + 50 ng/ml HGF.0.001 µM–10 µM erlotinib + 50 ng/ml HGF + 0.5 µM crizotinib.0.5 µM crizotinib + no ligand [additional].

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11772585

In vitro experiments showed that the survival, migration, and invasion of the cSCC cell lines HSC-1 and A431 were significantly inhibited upon METTL1 inhibition.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "...

PMC9429973

Aims: The goal of my project is to test the antileukemic potential of iD in cellular and animal models of DUX4-r leukemia.

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PMC9436459

Subsequently, more than 20 MDAAs were reported to have significant inhibitory activity against tyrosinase (Table 8) .Table 8Inhibitory activities of MDAAs against tyrosinaseCompd.

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PMC9429973

Aims: Here, we present the primary analysis from GEMSTONE-201, the largest registrational study reported to date to evaluate an anti-PD-L1 mAb in R/R ENKTL.

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PMC11499955

The technology uses MS-tag isotopologues and the sydnonimine-cyclooctyne click-and-release bioorthogonal reaction.

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PMC6379402

However, on our data, SNF returns empty integrated networks.

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PMC10748106

Geniposidic acid has an acid at C4, just like 10-O-(E)-p-coumaroylgeniposidic acid (this last one additionally presents a p-coumaroyl group at C10), contrary to Geniposide, which presents an ester at C4.

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PMC9596868

Combination treatment significantly reduced the colony formation ability of PA-1, A2780 and HCT116 cells as compared to individual treatments thereby confirming that the combinatorial treatment of quercetin and MST-312 effectively exacerbates cell death in these cells.

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PMC11597167

Similarly, EGCG also has anti-inflammatory and neuroprotective properties, and it has been proven that the production of TNF-α-induced monocytes is inhibited after EGCG treatment .

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PMC9429973

Many studies involved lymphopenia as prognostic factor for unfavourable evolution of COVID-19 patients.

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PMC10728200

To clarify the specific molecular mechanism of IM-induced ferroptosis, we examined the effects of different IM concentrations and treatment time on the expression of SLC7A11 and GPX4.

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PMC11521786

While this polyclonality was expected given that the whole extracellular domain of HER3 was used as the antigen, this result not only explains PAbs’ potential to downregulate the target receptor but also suggests that effector functions beyond target degradation could be elicited by these PAbs.

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PMC9429973

But there was no significant difference in terms of 1-year OS ([79.9 (60.5-90.4)%] vs [84.0 (61.2-94.0)%], P = 0.4411) or RR ([13.6 (2.73-33.2)%] vs [15.2 (4.40-32.1)%], P = 0.7416).

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PMC10565698

Sixty-seven paired LC and para-cancerous tissue specimens were collected between April 2019 and April 2020 from the Affiliated Hospital of Nantong University and the Nantong Third People's Hospital.

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PMC11469524

Model performance for each modeling step from the literature-derived starting model to the final model: (TOP) goodness of fit as weighted sum squared residuals divided by number of free parameters and (BOTTOM) consistency check step as percentage of error reduction compared to unperturbed control as null model (see S1 ...

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PMC11676169

After washing in PBS, cells were fixed with 4% paraformaldehyde and permeabilized with PBS-0.1% Triton-X (Sigma-Aldrich).

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PMC11423992

Therefore, subclones with low levels of CD20 expression should also be considered viable targets for TFAB002s.

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PMC11638288

Alon et al.’s study demonstrates that NKp46 can recognize the heparan sulfate portion of heparan sulfate proteoglycans (HSPGs) on cervical adenocarcinoma tumor cells and melanoma cells, thereby enabling NK cells to lyse tumor cells.

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PMC11756907

Graphs A, B, C, and D (Figure 4) show the cytotoxicity of the graphene-based compounds: GO, GO-2ME, RrGO, and RrGO-2ME in DMSO solvent against 143B cells.

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PMC8389560

In this state, the solid target was irradiated with a laser beam (λ = 1064 nm; T = 4–200 ns; f = 20 kHz; P = 20 W; Ep = 1 mJ).

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PMC9429973

Maximum expansion was reached at a median of 14.2 d by qPCR (13.9 d by flow cytometry).

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PMC7887261

Whether and how the c.*28delT affects POMC expression and their putative role to LC risk merit further mechanistic investigation.

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PMC11779993

The isolates were then adjusted in Mueller Hinton broth (MHB) using a 0.5 McFarland standard for a bacterial total concentration of 1.5 × 10 CFU/mL. Antibacterial activities of SPEE were investigated using the broth microdilution method, which was used to explore the minimum inhibitory concentration (MIC).

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PMC11721587

Subsequent interaction between SUMO and SUMO-interacting motif drives Fu/Ulk3 self-assembly to form biomolecular condensates that recruit Ci-Sufu and Gli-Sufu in the cytoplasm and primary cilium, respectively.

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PMC11711347

Chemotherapy, including the use of cisplatin, constitutes a fundamental component of cancer treatments .

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PMC11599565

Clusters of EpCAM negative cells with concurrent stemness and neuronal signature are observed.

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PMC11530949

The existence and interactions of the copper element are linked to the formation of many peaks in the 400–700 cm-1 range.

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PMC9429973

Key inclusion criteria were a diagnosis of MDS or CMML by WHO 2016, age ≥ 18 yrs, int-2 or high risk by IPSS, and bone marrow (BM) blasts of 5-19%.

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PMC11144200

Following the final recording, the mice had been euthanized,, their tumors removed and retained for further assays.

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PMC5673060

In both sets of experiments, analysis of the distribution of phosphorylated residues shows the expected classical distribution of pSer:pThr:pTyr ratios (~ 90:10:1) as previously reported (Fig. S1A) .

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PMC6889484

Primers CMVfor (5′-CAGAGCTCGTTTAGTGAACC-3′) and A3GendREV (5′-GATTCTGGAGAATGGCCCGC-3′) flank A3G(DK).

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PMC11750161

Dose-response curves were generated for experiments performed in duplicates.

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PMC9111184

In addition, PC2 loadings plot showed positive loadings at 1637 and 1683 cm.

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PMC10698968

In addition to or before surgery, a chemotherapeutic treatment based on the alone or combined administration of doxorubicin and ifosfamide is mainly used as a palliative intervention due to the lack of consistent data obtained by clinical studies .

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PMC9429973

AZA treatment can improve PB counts and delay progression to Akute Myeloid Leukemia.

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PMC6461034

Fourth, another substrate‐centric analysis is included to complement the previous step.

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PMC11371747

DHFR in humans has a markedly lower capacity (50-fold) to convert folic acid to DHF and THF then in widely used animal model systems such as the mouse (Bailey and Ayling, 2009).

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PMC10988555

Statistical analysis was performed by the two-way ANOVA method.

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PMC3164356

However, CHO ST6Gal genes are not expressed, so CHO glycans primarily have α(2,3) linkages. (

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PMC11489351

We similarly used MetaCore pathway analysis software (Clarivate Analytics, https://portal.genego.com) to identify the cellular pathways with a high incidence of genes differentially regulated by pHi (see Methods, Table S5).

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PMC11679326

Also, as a therapeutic agent, APL was used to target hepatocellular carcinoma Hep3B, Huh7, and PLC/PRF/5 cells and breast cancer MCF-7 and MDA-MB-231 cells .

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PMC11190238

Currently, we discussed the EMT spectrum in the context of transcriptional signature, there are other functional subtypes of the spectrum, including the ameboid state.

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PMC3122064

Transfection with the scrambled siRNA had no effect on p53 levels or Nutlin-3-induced apoptosis, further demonstrating the wild-type p53-dependent effect of Nutlin-3 in TC cells.

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PMC9351137

C Examples of IFM staining.

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PMC9429973

J. DiRaimo, C. Kruse, A. Kruse, M. Lambert, J. B. Bussel Platelet Disorder Support Association, Cleveland; Tulane University School of Medicine, New Orleans; Hematology, Children’s Hospital of Philadelphia, Philadelphia; Pediatric Hematology/Oncology, New York Presbyterian Hospital - Weill Cornell Medicine, New York, U...

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PMC10698968

In the following months the patient presented vertebral metastases (see MRI Fig. 1A bottom right) and died a few months later.

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PMC10671321

Samples (3–10 μL) were added to 200 µL of Ellman assay medium, and the reaction was monitored at 405 nm with a Byonoy Absorbance 96 (byoabs00835).

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PMC6468656

Acylated ghrelin (n-octanoyl) was prepared in ddH2O.

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PMC9429973

Summary/Conclusion: Our study has shown that horizontal transmission of microbiota/pathogens to immunologically naïve adult mice leads to a reduction in HSC function similar to that shown by other groups with more severe infection models.

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PMC9046263

Human endogenous retroviruses (HERV) are ancestral remnants of previous germline retroviral infections and account for 8% of the human genome.

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PMC9872547

RNA was reverse transcribed using a cDNA synthesis kit (Favorgen Biotech Company, Taiwan).

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PMC11799978

CAFs were then treated with various concentrations of NaHCO3 (0, 40, 80, 160, and 320 μg/mL) for a further 24 h. (B) Ratio of cell length to width in normal fibroblasts compared to CAFs treated with or without NaHCO3; and (C) phenotypic markers of fibroblasts assessed by flow cytometry. (

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PMC11451940

Cells were seeded in a 24-well cell culture plate at 5 × 10 cells per well and allowed to grow for 24 hours.

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PMC11734514

The ability of A549 cells to cover scratches after treatment with C. aerizusa extract for 24 hours decreased over time (Figure 4).

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PMC7351993

Since the linewidth of each wavelength channel is <10 cm and the bandwidth of the SRS microscope is about 300 cm, the number of colors can, in principle, be boosted to ~30, assuming that there is no spectral overlap between the consecutive channels.

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PMC9917080

Our experiments show that both free sorafenib and the SeSo nanocomplex did not cause cell death in cortical astrocytes.

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PMC6799808

A diagram showing that GLPT inhibits mTORC1/2-mediated signaling pathways, thereby inhibiting cell proliferation and inducing cell death in tumor cells ReishiMax GLp, a standardized G. lucidum extract containing 13.5% polysaccharides and 6% triterpenes here termed GLPT, was purchased from Pharmanex (Provo, UT, USA).

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PMC11185260

Combining emerging knowledge regarding SMARCB1 with nanotechnology, which enables brain tumor-targeted gene delivery, we assessed the potential of SMARCB1 restoration in ATRT using our nanomedicine (termed scL-SMARCB1).

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PMC11443022

In peripheral blood lymphocytes, 45,X was observed in 5 out of 20 cells, while 46,XY was detected in 15 out of 20 cells. (

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PMC11012012

Using tumor tissue microarrays, Roncador et al. (2022) analyzed the expression of SLAMF3/CD229 in 205 patients with nine different subtypes of B-CLPD.

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PMC9429973

Of them, we found that omipalisib had more significant effect to inhibit “Oxidative phosphorylation” (NES: -2.01) than gedatolisib did (NES: -1.40), especially mitochondrial biogenesis and amino acid metabolism-related pathways.

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PMC11371747

Antifolate sensitivity was determined in four selected NSCLC and MPM cell lines (Figure 8).

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PMC10772747

Flow cytometry was used to analyze cell cycle distribution after treatment with specific compounds.

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PMC10713411

The mRNA expression of KIRC and KIRP was normalized and transformed into the form of Log2 (TPM+1).

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PMC11754784

n > 30 from different cells).

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PMC11502962

Seven cell types were identified in the single-cell analysis.

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PMC9429973

but markedly longer (median 116 months vs not reached) in patients with mutated IGHV without del 11q (HR 0.90; p=n.s.;

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PMC11803149

A-F) n = 3 per group.

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PMC11279397

Given this, it is crucial to further research and develop Perilla frutescens and its primary constituents to enhance its antiviral capabilities.

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PMC11727062

Gambogic acid has been reported to reduce the viability of A375 cells, induce apoptosis, attenuate cell migration and invasion, and increase the sensitivity of drug-resistant cells to therapy.

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PMC10854447

The epidermal growth factor receptor (EGFR) is a type of membrane receptor tyrosine kinase that is overexpressed in various tumours.

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PMC10094712

Knockdown of the SELENOM gene in rats resulted in an increase in the activity of glutathione peroxidases and thioredoxin reductases in the brain, liver, lungs, and, to a lesser extent, in the kidneys and heart.

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PMC5811757

Target amplification efficiency was equal to that of the reference genes.

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PMC10858941

The left side corresponds to the centre of the chip (“Core”), where there is central hypoxia, while the right side corresponds to the region in contact with the side channels (“Lateral channel”). ***

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PMC11802929

Dominant clones were defined as clone size >= 50 based on 10X VDJ library readout (which counted all cells in the pre-filtered dataset).

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PMC11745823

In some malignant tumours such as lung adenocarcinoma, RIT1 mutations appear to be mutually exclusive with mutations in currently known driver genes such as KRAS and EGFR, which suggests that RIT1 may be an independent oncogenic factor in some tumours .

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PMC9429973

Muscle strength and SMI were significantly lower in patients with sarcopenia (p: 0.035; p: 0.01, respectively) (Table 1).

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